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Dibazol in m instructions for use. "Dibazol" - from what? Antispasmodics. Dibazol tablets instructions for use

1 ml of solution contains

active substance: bendazole hydrochloride - 10 mg

Excipients: ethanol 96%, glycerin, 1 M hydrochloric acid, water for injection.

Description

Clear, colorless or slightly yellowish or greenish liquid.

Pharmacotherapeutic group

Peripheral vasodilators. Other peripheral vasodilators.

ATX Code S04AX

Pharmacological properties

Pharmacokinetics

When administered intramuscularly, the drug quickly penetrates into the systemic circulation. The maximum concentration in the blood is observed after 15-30 minutes from the moment of administration. Duration of action - 2-3 hours. Metabolized in the liver.

The biotransformation products of dibazole are two conjugates formed as a result of methylation and carboethoxylation of the imino group of the imidazole ring of dibazole: 1-methyl-2-benzylbenzimidazole and 1-carboethoxy-2-benzylbenzimidazole.

Metabolic products are excreted mainly in the urine.

Pharmacodynamics

Vasodilator and antispasmodic. It has a hypotensive, vasodilating effect, stimulates the function of the spinal cord, has a moderate immunostimulating activity.

It has a direct antispasmodic effect on the smooth muscles of blood vessels and internal organs. The drug causes a short (2-3 hours) and moderate hypotensive effect, well tolerated.

Causes a short expansion of the cerebral vessels in chronic hypoxia of the brain caused by local circulatory disorders (sclerosis of the cerebral arteries).

Facilitates synaptic transmission in the spinal cord.

It has immunomodulatory activity. By regulating the ratio of the concentrations of cyclo-guanosine monophosphate (cGMP) and cyclo-adenosine monophosphate (cAMP) in immune cells, it increases the content of cGMP, which leads to the proliferation of mature sensitized T- and B-lymphocytes, the secretion of factors of mutual regulation by them, a cooperative reaction and activation of the final effector cell functions. The drug stimulates the production of antibodies, enhances the phagocytic activity of leukocytes, macrophages, improves the synthesis of interferon, but the immunomodulatory effect develops slowly.

Indications for use

Exacerbations of hypertension, hypertensive crises, as an additional remedy

Spasms of the pylorus of the stomach, intestines, as an additional remedy

In the treatment of neurological diseases (mainly residual effects of poliomyelitis, peripheral facial paralysis, polyneuritis).

Dosage and administration

Adults and children over 12 years of age are prescribed Dibazol-Darnitsa intravenously, intramuscularly or subcutaneously. To stop hypertensive crises, 3-5 ml of a 1% solution (30-50 mg) is administered intravenously or intramuscularly. With a significant increase in blood pressure, intramuscular administration of 2-3 ml of 1% of the drug (20-30 mg) 2-3 times a day is indicated. The course of treatment is prescribed individually, on average - 8-14 days.

Side effects

Dizziness, headache

Palpitations, pain in the region of the heart, with prolonged use - worsening of ECG parameters due to a decrease in cardiac output, lowering blood pressure

Dry cough, runny nose, difficulty breathing

Nausea, burning in the throat

Itching, hyperemia, rashes, urticaria

Feeling hot, sweating, redness of the face

Reactions at the injection site: local soreness.

Contraindications

- hypersensitivity to bendazole or to auxiliary components of the drug

Diseases that occur with a decrease in muscle tone, convulsive syndrome, severe heart failure

Arterial hypotension

Chronic nephritis with edema and impaired nitrogen excretion of the kidneys

Peptic ulcer of the stomach and duodenum with bleeding

Diabetes

Children's age up to 12 years

Pregnancy and lactation

Drug Interactions

If you are taking any other medicines, be sure to consult your doctor about the possibility of using the drug. .

Papaverine hydrochloride, theobromine, salsoline - when combined with dibazol, the spectrum of pharmacological action of papaverine hydrochloride, theobromine, salsoline expands.

Barbiturates - when combined with dibazol, the effectiveness of long-acting barbiturates, in particular phenobarbital, is enhanced.

Phentolamine, antihypertensive drugs (drugs that affect the renin-angiotensin system, etc.), saluretics - when combined with dibazol, the hypotensive effect is enhanced.

β-blockers - when combined with dibazol, the hypotensive effect of the latter does not change, but with prolonged use, dibazol prevents an increase in total peripheral resistance caused by β-blockers.

Dibazol is incompatible with salicylates and benzoates, since precipitation of dibazole salicylate or benzoate occurs.

special instructions

Before starting treatment, consult your doctor!

Dibazol in the form of injections is an adjuvant that is used for arterial hypertension, subject to sensitivity to other antihypertensive drugs. In the treatment of arterial hypertension, it is recommended to combine with other antihypertensive drugs.

It is not advisable to use Dibazol-Darnitsa for a long time as an antihypertensive agent in senile patients due to the possibility of deterioration in ECG parameters and a decrease in cardiac output.

Features of the influence of the drug on the ability to drive vehicles and especially dangerous mechanisms

During treatment, care should be taken when driving vehicles and working with complex mechanisms, and in case of dizziness, refrain from working with potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Overdose

Symptoms: hypotension, sweating, feeling hot, dizziness, nausea, mild headache, which quickly pass when the drug is discontinued.

Dibazol is perhaps the most famous domestically produced antihypertensive drug. It is prescribed in their practice by cardiologists and therapists. This article will tell you about what properties this medicine has, what indications for use it has according to the instructions, how its dosage is prescribed for children and adults, whether it is possible to use the drug during pregnancy, what its analogues are, the cost and reviews of patients, and much more.

Indications for use Dibazol

In Latin Dibazol. This is a drug whose main effect is based on the ability to reduce pressure when it jumps up. The main indications for taking the medicine are as follows:

Hypertension in the initial stages;
crises of a hypertensive nature;
vegetovascular disorders with a tendency to high blood pressure;
spasms of smooth muscles of internal organs (gastric colic, stomach and duodenal ulcers, and so on);
diseases of the nervous system, including poliomyelitis in children;
to stimulate the immune system with influenza, colds and SARS.

Contraindications for use

The drug is different in that its contraindications are minimal, or rather there are only two of them:

  • personal intolerance to the remedy;
  • tendency to hypotension (low blood pressure).

Compound

Dibazol is available in two dosage forms - tablets for oral administration and ampoules with a solution for intramuscular or intravenous administration. Dibazol has the following composition:

The main active ingredient is bendazole (benzylbenzimidazole hydrochloride);
excipients - lactose, talc, potato starch, calcium stearate and others.

Dibazol instructions for use

Despite the fact that the medicine is practically harmless, its appointment and subsequent intake are only permissible if there is a doctor's prescription for this - a prescription. Next, consider the recommended doses of the drug for adults, children and pregnant women.

Dibazol instructions for use at what pressure they give - dosage for adults

Tablets for adults are prescribed in the following dosage:

With hypertension - inside 20-50 mg 2-3 times a day for a month;
with VVD - 5 mg 1 time per day for 5-10 days.

Dibazol UBF instructions for use

The dosage, according to the doctor's prescription, most often appears as follows:

Adults - tablets of 20-50 mg 2-3 times a day;
Children - 1-5 mg once a day.

However, do not forget that the amount of medication per day is selected individually and the dosage recommended by the manufacturer does not always coincide with the data that the doctor writes in the prescription.

Dibazol injections instructions for use

The most popular way to reduce a sharply increased blood pressure is an intramuscular injection of a solution of papaverine and dibazol in one syringe.

Dibazol with papaverine instructions for use are as follows: 2 ml of papaverine and 4 ml of dibazol are combined in a syringe, the injection is administered intramuscularly to reduce high blood pressure. Such injections are often made by ambulance doctors who go to the call to the patient.

Dibazol in ampoules instructions for use

To reduce high blood pressure - 30-40 mg intramuscularly or intravenously once a day;
with persistent hypertension - 20-30 mg up to 3 times a day.

For flu and colds

Experts noted that this medication can also be successfully used in therapeutic practice for the treatment of influenza and colds. The medicine helps to relieve internal spasms, stimulates the immune system, and also enhances the production of interferon.

Dibazol tablets instructions for use for influenza

For influenza, colds, SARS, Dibazol tablets are also prescribed as part of complex therapy, since this drug enhances the production of interferon. Following the instructions, in this case, the agent is used one tablet once a day.

Infants dosage and indications for use

Babies should be given the drug only as prescribed by the doctor and under his close supervision. Especially for babies, according to the doctor's prescription, pharmacies prepare special solutions, which, according to the instructions for their use, are indicated for use in:

Muscle spasms that arose as a result of intrauterine hypoxia;
chromosomal syndromes;
colic of internal organs;
with colds, flu and SARS.

Dibazol has the following analogues, the effect of which is comparable to our drug: bendazol, sakur, accardium, coronal, corinfar and others.

A drug called "Dibazol" was created more than 60 years ago, but neurologists, cardiologists, pediatricians and other specialists actively prescribe it today. Not everyone knows whether it is allowed for children and how it affects the children's body.

Release form

The drug is produced in the following forms:

  • Tablets placed in paper contour packs of 10 pieces. One pack may contain from 10 to 60 tablets.
  • Solution in ampoules, intended for intramuscular or intravenous injections. One ampoule may contain 1, 2 or 5 ml of this colorless clear solution.

In addition, "Dibazol" is represented by a powder substance, from which powders with glucose are made according to the doctor's prescription. In relation to the preparation of such a form, intra-pharmacy control operates. This powder can be made only in specialized pharmacies.

Compound

The active ingredient in Dibazol is a substance called bendazol. One tablet contains 20 mg of such a compound, and the concentration of bendazole in an ampoule is either 0.5% (5 mg per 1 ml) or 1% (10 mg per 1 ml). Auxiliary components of the tablets are lactose, potato starch, calcium stearate and other substances that give the drug density and help keep its shape. The ampoules contain the active ingredient, sterile water, ethanol, hydrochloric acid and glycerol.

Operating principle

Since bendazol is able to act on smooth muscles and cause them to relax, "Dibazol" belongs to the group of myotropic antispasmodics. Due to this effect, the drug causes vasodilation, resulting in a decrease in blood pressure. Such an effect is called moderate and short-lived, since it is observed only within 2-3 hours after the use of the drug.

However, this tool has other therapeutic effects:

  • Its reception stimulates the transmission of nerve impulses in the spinal cord.
  • The drug is able to activate the synthesis of protein molecules and nucleic acids.
  • It is an immunomodulator, since it is able to stimulate the formation of interferon, the process of phagocytosis and the synthesis of antibodies.

Indications

The tool is used for babies in such cases:

  • With neurological pathologies - for example, after a birth injury, with paralysis of the facial nerve, or to eliminate the effects of poliomyelitis. One way to administer the drug in such situations is electrophoresis.
  • To increase immunity in colds and viral infections, as well as to prevent influenza.
  • In diseases of the internal organs, in which spasms of smooth muscles occur - for example, with renal, hepatic or intestinal colic.

At what age is it allowed to take?

The medicine is used for children of any age, but only as directed by a doctor. Giving "Dibazol" to a child without consulting a specialist is not recommended.

Contraindications

The drug is not used in case of hypersensitivity to bendazole or its other component. It should not be prescribed for low blood pressure.

Side effects

During treatment with Dibazol, a child can observe:

  • Nausea.
  • Allergic reaction to the drug.
  • Headache.
  • Increased perspiration.
  • Dizziness.
  • Feeling hot.

Instructions for use and dosage

Taking into account the disease and the condition of the child, the doctor chooses the appropriate form of the drug and the method of its use, and the determination of the dosage depends on the age. Children up to a year "Dibazol" are prescribed 1 mg per day. For babies older than a year to 12 years of age, the dose is selected individually (from 2 to 5 mg per day).

The course of treatment for neurological pathologies is 3-4 weeks. If necessary, he is appointed again - after one or two months. For colds, the drug is prescribed together with calcium gluconate or vitamin C. For the prevention of viral diseases, Dibazol should be taken in the form of tablets for a long time - at least a month.

Overdose

If you exceed the dose of Dibazol for a child, this will lead to an increase in the side effects of such a drug - for example, it will cause nausea and a feeling of heat.

Interaction with other drugs

  • The combination of "Dibazol" and papaverine hydrochloride has a stronger antispasmodic effect than each of the drugs separately.
  • When administered with other antihypertensive drugs, their therapeutic effect is enhanced.
  • Ascorbic acid has the property of enhancing the immunostimulating effect of Dibazol.

Terms of sale and storage

To buy the injectable form of the drug, you need a prescription from a doctor, and the tablets are over-the-counter. The price of 10 ampoules averages 25-35 rubles. You need to keep Dibazol at home in a dry place (at a temperature below +25 degrees), where a small child cannot get the medicine. The shelf life of ampoules is 4 years, tablets - 5 years.

Dibazol is a tonic, myotropic and antispasmodic drug. Instructions for use indicate that 20 mg tablets, injections in 1% injection ampoules have a hypotensive and vasodilating effect. According to cardiologists and neurologists, this drug helps in the treatment of spasms, pressure and diseases of the nervous system in adults, children (including newborns), they also report at what pressure to take this medicine.

Release form and composition

Dibazol is manufactured in two dosage forms - tablets for oral administration and a solution for parenteral (intramuscular or intravenous) administration. The main active ingredient of the drug is bendazole. Its content in one tablet is 0.02 g, in 1 ml of solution its content is 0.01 g (10 mg or 1% solution).

The tablets are packaged in a blister pack of 10 pieces. The solution for injection is contained in 2 ml glass ampoules, the package contains 10 ampoules.

Indications for use

What helps Dibazol? Tablets and injections are prescribed to patients who suffer from spasms of vascular smooth muscle tissue. The medication can be used to stop a hypertensive crisis.

With spasm of the smooth muscles of the internal organs (intestinal colic, peptic ulcer, pancreatitis, cholecystitis), the severity of the pain syndrome decreases due to muscle relaxation.

Indications for the use of Dibazol in neurology:

  • treatment of residual effects of poliomyelitis;
  • flaccid paralysis syndrome;
  • paralysis of the facial nerve.

What are the pills for?

The tablet form has found wide application in medical practice: cardiology, neurology, therapy, gastroenterology.

Dibazol, what else helps?

The drug helps to reduce pressure, relieve spasms and reduce the severity of pain that occurs against the background of spasm of smooth muscle tissue.

Instructions for use

Dibazol is taken orally (2 hours before or 2 hours after a meal), intravenously, intramuscularly.

  • Relief of hypertensive crises: intravenously or intramuscularly - 30-40 mg.
  • Exacerbation of arterial hypertension with a significant increase in blood pressure: intramuscularly - 20-30 g 2-3 times a day, the course of treatment is 8-14 days. Inside - 20-50 mg 2-3 times a day for 3-4 weeks.
  • Treatment of diseases of the nervous system: adults - 5 mg (daily or every other day) 5-10 times, a second course is carried out after 3-4 weeks, subsequent courses - with a break of 1-2 months.
  • In diseases of the nervous system in children: up to 1 year - 1 mg, 1-3 years - 2 mg, 4-8 years - 3 mg, over 12 years - 5 mg.

See also: at what pressure and how to take a close analogue -.

pharmachologic effect

The therapeutic effect of the use of Dibazol occurs due to the implementation of the following actions of the drug:

  • Venous vessels expand more than arterial ones, which helps to reduce the load on the heart by reducing blood flow to it and increasing the volumetric blood flow velocity in the coronary vessels.
  • Stimulating effect on interneuronal transmission of electrical impulses in the spinal cord.
  • Moderate immunomodulatory effect. It is implemented due to the ability of Dibazol to enhance the production of interferon.
  • Spasmolytic action. Dibazol relieves spasm of smooth muscles of blood vessels, as well as muscles of internal organs.
  • Hypotensive (lowering blood pressure) action. It comes after the expansion of blood vessels and the removal of spasm.
  • Vasodilating action. The drug causes a short-term expansion of blood vessels, resulting in improved blood circulation in them.

Contraindications

The use of tablets or solution for parenteral administration of Dibazol is contraindicated in case of individual intolerance to the components of the drug. Also, its use is excluded during pregnancy at any time, during breastfeeding and some pathological conditions of the body:

  • Diabetes mellitus type 1 or 2.
  • Pronounced decrease in muscle tone.
  • Convulsions.
  • Renal failure with a pronounced decrease in the urinary function of the kidneys.
  • The presence of an ulcer of the duodenum or stomach, from which bleeding periodically develops.

Before starting the use of the drug, you must make sure that there are no contraindications.

Side effects

Dibazol is characterized by good tolerance, rarely recorded changes in the electrocardiogram associated with a change in the ejection fraction of the left ventricle. In predisposed individuals, allergic responses, arterial hypotension, and dizziness may be recorded.

With the introduction of the drug Dibazol / in the development of pain in the injection area is possible.

Children, during pregnancy and lactation

It is possible to prescribe Dibazol during pregnancy if the intended benefit outweighs the potential risk to the fetus. When taking the drug, it is recommended to interrupt breastfeeding.

In childhood

For older children, tablets with a dosage of 4 mg are produced; for infants, solutions are prepared at specialized points in pharmacies.

For older children, tablets with a dosage of 4 mg are produced; for infants, solutions are prepared at specialized points in pharmacies. In pediatric practice, the drug is prescribed for the following conditions:

  • colic and spasms. The drug has a mild effect on smooth muscles, relieving babies from pain caused by spasm of smooth muscle tissue of internal organs;
  • muscle hypotension that developed after a difficult birth, as a result of prolonged hypoxia, hereditary pathology of the neuromuscular apparatus, with various chromosomal syndromes;
  • influenza, SARS, colds. The drug enhances the production of interferon when the virus enters the child's body;
  • stress and fatigue. Dibazol is characterized by an adaptogenic effect, which allows you to increase the nonspecific resistance of the child's body.

special instructions

It should be used with caution in elderly patients. It is not recommended to use Dibazol from pressure for a long time (for the treatment of arterial hypertension), especially for elderly patients.

When treating with Dibazol, care should be taken when driving vehicles and performing work that requires increased concentration and immediate psychomotor reactions, due to the risk of developing headache attacks and dizziness.

drug interaction

An increase in the severity of the antihypertensive effect was registered with simultaneous use with diuretic drugs and antihypertensive agents. Bendazole is able to prevent an increase in OPSS caused by taking beta-blockers. The hypotensive effect of Dibazol is enhanced by taking Fentolamine.

Analogues

  1. Bendazol.
  2. Dibazol Vial; Darnitsa; UBF.
  3. Dibazol solution for injections 1%.

Holiday conditions and price

The average cost of Dibazol (tablets 20 mg No. 10) in Moscow is 17 rubles. The price of injections is 25 rubles for 10 ampoules. Released by prescription.

Keep out of the reach of children. Best before date:

  • Tablets: 5 years at room temperature (not higher than 25 C).
  • Solution for injection: 4 years at a temperature of 5-30 C.

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Dibazol is a drug belonging to the group of antispasmodics, has the ability to dilate blood vessels and relieve spasms. It lowers blood pressure and stimulates the functions of the spinal cord and brain. The drug is produced in the form of tablets and injections, which are administered intravenously with saline or intramuscularly for spasms of blood vessels, smooth muscles of the gastrointestinal tract, for hypertensive crises and some other diseases of the nervous system.

Although the drug is dispensed in a pharmacy by prescription (except for Dibazol-UBF), you need to know the instructions for its use, for what indications and in what form it is better to use it in a particular situation. Description of the drug, methods of its use, described in the article, will help users to use this medicine effectively, as well as learn about contraindications and possible side effects.

Dibazol history of creation

Dibazol is one of the few drugs that has not lost its relevance to this day. It still occupies an important place in medicine. It is part of many modern medicines. It was invented by Soviet scientists back in 1947. The drug owes its name "Dibazol" to Professor Nikolai Vasilyevich Lazarev. And the history of its creation is as follows.

During and after World War II, the demand for drugs that stimulate the nervous system and can lower blood pressure skyrocketed. Not only the Soviet Union, but the whole of Europe lay in ruins, millions of people crippled by the war needed medicine. In addition, there were diseases generated by war and devastation. And the choice of such drugs was not so wide. In fact, only papaverine was present on the pharmaceutical market, which was obtained from the juice of the Turkish poppy.

Then scientists thought about the synthetic synthesis of a drug with a similar spectrum of action. Abroad, medical scientists and pharmacists directed all their main efforts to the creation of simple and cheap methods for synthesizing papaverine.

Our scientists have gone the other way. After conducting research, they found that the main relaxing effect of papaverine on smooth muscles is due to the presence of a heterocyclic nucleus and a benzyl alcohol residue in the molecule. Then they suggested that other similar chemical compounds can have the same relaxing effect. For the first time such a hypothesis was put forward by a Soviet doctor, scientist professor of the Department of Pharmacology of the Second Leningrad Medical Institute Sergey Viktorovich Anichkov.

Such a compound called 2-benzylbenzimidazole was already familiar to the scientific world. It was first synthesized by German scientists back in 1889. But at that time he did not arouse any interest among doctors and soon forgot about him. Soviet scientists remembered him. Synthesis of the drug was carried out by a group of Soviet chemists led by Professor B. A. Porai-Koshitse.

Now it's hard to believe, but the new drug, which was created to somehow alleviate the pathologies of the nervous system and paralysis, was introduced into medical practice without passing all the necessary studies. It has only been tested on cats, guinea pigs, and a small group of volunteer graduate students.

But next to the department of the Military Medical Academy, where the tests were carried out, there were hundreds of children stricken with poliomyelitis, and medicines were needed already "not today, but yesterday."

At that time, he justified himself, out of 100 children treated by him, 90 noted improvement. Positive results have been obtained in trials for the treatment of patients with polyneuritis in the VMMA. The first batch of the drug on an industrial scale was released in 1950 by the pharmacological enterprise "Farmak" in the city of Leningrad.

Nowadays, the students of N. V. Lazarev have revealed new possibilities of dibazol: its ability to increase the body's resistance to adverse conditions, which leads to its use in influenza, colds, and SARS. And yet it is more known precisely as a medicine that lowers high blood pressure.

Dibazol composition

Its chemical formula is 2-benzylbenzimidazole hydrochloride, the content of this substance in a tablet is 20 milligrams.
A tablet is formed with the help of excipients: sugar, potato starch, polyvinylpyrrolidone, medical milk sugar and talc.

The active substance is bendazole, a powder of white or with a slight grayish or yellowish tint, bitter-salty taste, which provides the main medicinal properties. It is easily soluble in water and alcohol, hygroscopic.

The drug belongs to the pharmacological group of peripheral vasodilators. The drug can go on sale in the form of white tablets called Bendazole.

Dibazol from what helps, medicinal and pharmacological properties

Dibazol refers to broad-spectrum drugs with antispasmodic, hypotensive, immunostimulating properties. It relieves vasospasm and stimulates the functions of the spinal cord.

The medicine, no matter in what formulation it is used, has the same effect on the patient's body:

  • Relieves muscle spasms of smooth muscles of internal organs. This effect is achieved by blockade of calcium channels;
  • Reduces the pressure that blood exerts on the walls of blood vessels;
  • Expands peripheral vessels, which improves the delivery of oxygen to tissues. By expanding the vessels, the drug ensures normal blood supply to the brain and spinal cord;
  • The drug has the ability to increase the formation of interferon in the body, which strengthens the immune system.

All the properties of this drug allow it to be used as an additional drug in the course of treatment of patients with neurological diagnoses.

The medicinal properties on the body include:

  • Has a vasodilating property;
  • They block nerve impulses going to the muscles of smooth muscles;
  • Stimulate the work of nerve cells of the spinal cord;
  • Restores the action of the nervous system, connecting the central nervous system with the rest of the body;
  • Promotes additional production of interferon, necessary to strengthen the immune system.

Dibazol indications for use

Dibazol refers to drugs with a wide spectrum of pharmacological action. Therefore, when prescribing it to patients, the doctor is based on the individual characteristics of a particular patient, on the results of examinations and tests. Only a doctor can prescribe a course of treatment, paint a schedule, rate and form of taking the drug.

It can be not only tablets. Treatment may be by intramuscular or intravenous administration of the drug.

The main diseases that serve as indications for the use of dibazol:

  • A persistent increase in blood pressure is arterial hypertension. Pressure is registered from 140/90 mm. rt. Art. and higher;
  • Hypertensive crisis;
  • Disease of the internal organs with severe spasms of their smooth muscle tissues. These include peptic ulcer of the stomach and duodenum, pylorus;
  • Diseases of the neurological profile. Doctors pay special attention to children with residual symptoms of poliomyelitis;
  • Injuries received during childbirth;
  • Paralysis of the facial nerve, as a result of which the movement of the muscles of the face is disturbed.

Dibazol tablets instructions for use

Indications for the use of dibazol tablets are as follows:

  • Involuntary contraction of the vessels of the circulatory system during exacerbation of hypertension;
  • Peptic ulcer of the stomach and intestines;
  • Flaccid paralysis syndrome, expressed by a decrease in muscle tone.

Tablets quickly dissolve and are absorbed by the gastrointestinal system, forming two components of Dibazol - its methylated and carboxylated form of the imino group of the imidazole ring.

The therapeutic effect of the drug appears within an hour after taking it. The analgesic and soothing effect lasts for three hours.

Taking tablets in the treatment of neurological diseases Dibazol is prescribed 5 grams every other day or once a day. The course of admission can be from 5 to 10 days. If necessary, the treatment is repeated no earlier than after three or four weeks. To achieve a positive effect, subsequent courses are carried out with a break of 1 - 2 months. In this case, a higher single dose per day is allowed up to 10-15 mg (for adults), taken in two or three doses.

Inside Dibazol is taken 2 hours before meals or 2 hours after meals.

Before starting the course of treatment with the drug, be sure to consult with your doctor. He will clarify the regimen of admission and the daily rate. In the course of the course, these parameters may change depending on its effect for a particular patient.

Dibazol in injections instructions for use

Treatment of diseases of a neurological profile should be carried out in a course lasting 10 days without a break. The recommended dose is no more than 5 ml of solution per day.

Repeated treatment with intramuscular injections is possible after 3-4 weeks.

With worsening arterial hypertension with significant blood pressure, intramuscular injection of 2-3 ml of a 1% solution or 4-6 ml of a 0.5% solution (0.02-0.03 g) 2-3 times a day is indicated. The course of treatment is from 8 to 14 days.

In the case of an increase in blood pressure, treatment can be carried out every month by introducing a solution of the drug until the patient's condition normalizes and the blood pressure readings decrease.

During the course of treatment with Dibazol, it is possible to use other drugs that lower blood pressure, for example, Reserpine, Hypothiazid and others.

Dibazol during pregnancy and lactation

Dibazol refers to drugs that are safe for women with any stage of pregnancy and breastfeeding. Prescribe a medicine in case of high blood pressure, due to its quick and mild action. The virtual absence of side effects allows you to quickly stabilize the condition of women, moreover, the effect of tablets and injections is the same.

If it is necessary to take Dibazol, breastfeeding women are advised to interrupt breastfeeding.

Dibazol instructions for use for children

Regardless of the form of release, the drug is not prescribed to children under 12 years of age. The manufacturer guarantees the safe use of the drug in the treatment of children over 12 years of age and older.

Treatment is carried out only on prescription. He sets the regimen and dosage of the drug. For intramuscular administration to children, the drug is diluted with specially prepared water or sodium chloride solution. The dose is usually prescribed in the range of 0.25-1.0 ml.

For treatment with tablets, the child is prescribed the drug, one tablet three times a day. If the child has spasms, then the intake rate is reduced to 1/2 tablet for 1-2 days.

The safety of the treatment of infants has not been proven, therefore, the use of dibazol for their treatment is excluded.

But sometimes doctors prescribe it for the treatment of diseases of the nervous system. In this case, the admission norms are no more than:

up to 1 year - 0.001 g;

from 1 year to 3 - 0.002 g;

from 4-8 years old - 0.003 g;

from 9-12 years old - 0.004 g.

Contraindications to the use of dibazol

The drug "Dibazol" has contraindications, a list of which is given in the instructions attached to the drug. Although this drug is sold without a prescription (tablets only), you should undergo a medical examination and get the advice of a doctor before using it. This procedure is necessary to identify deviations that can lead to adverse health effects.

A contraindication to the use for the treatment of a patient is:

  • Allergy to the components that make up the tablets or injection solutions;
  • Periodic bouts of low blood pressure;
  • The presence of diabetes mellitus;
  • Age category less than 12 years;

Particular attention is paid to elderly patients (for the elderly, it is not prescribed or prescribed for a very short time). Based on the results of medical tests, the doctor may allow or prohibit the use of Dibazol, replacing it with another medicine.

Side effects of dibazol

Self-administration of the drug without consulting a doctor or failure to follow his recommendations may have an undesirable effect on the patient's health. The most common side effects of this medication are:

  • Rashes on the body that cause itching;
  • Redness of the skin of the face;
  • Redness and itching at the injection site of the drug solution;
  • Headache attack;
  • Abdominal pain, bloating;
  • Headache attacks accompanied by dizziness;
  • Attacks of nausea with salivation;
  • A state close to fainting.

If the deviations that appear do not go away for a long time, you should consult a doctor.

Interaction of Dibazol with other drugs

Dibazol is combined in different ways with other drugs that can be prescribed by doctors for other diseases.

Combination with drugs such as Reserpine, Clonidine or Phenolamine, enhances the effect of lowering blood pressure, you can expect a sharp decrease.

Reception with ascorbic acid will enhance its effect as an immune stimulant.

Combined use with papaverine increases the effect of blockade of nerve impulses that cause painful muscle contraction.

In the postpartum period, the use of dibazol together with papaverine is unacceptable, as this can provoke uterine bleeding. In this case, only Dibazol is used.

Dibazol's analogs

In medical practice, drugs are used that include dibazol. Such drugs belong to the group of combined. This:

  • Papazol, tablets, their main components are papaverine and dibazol. The drug is used to treat patients with a low increase in pressure in the circulatory system.
  • Theodibaverine, the main components of which are Dibazol, Papaverine, Theobromine, is used in the diagnosis of brain spasms, the detection of impaired functioning of the kidneys and heart.
  • Andipal, contains Phenobarbital, Dibazol and Analgin. Tablets with this combination of components have a vasodilator, analgesic and antispasmodic properties. It is recommended for spasms of the vessels of the internal organs.
  • There are drugs whose action is similar to the work of the drug Dibazol. These include: Bendazol and its variants: Dibazol Darnitsa and Dibazol Vial.
  • Medicines have a similar effect: Gliofen, Dibenzimil, Galidor, Vinoksin.

This list can be continued, but it should be borne in mind that each drug should be purchased only in strict accordance with the doctor's recommendations. The independent choice of drugs and their use without the knowledge of a specialist is unacceptable.

Following strictly each item of the instructions for use of the drug, the recommendations of the attending physician, will allow you to correctly and safely use the medicine in the form of a solution and tablets and avoid negative consequences.

Dibazol for flu how to take