Panadol instructions for use, effervescent tablets. Panadol® soluble tablets. During pregnancy and lactation

Has restrictions when breastfeeding

Has restrictions for children

Has restrictions for older people

Has limitations for liver problems

Has limitations for kidney problems

Every person, regardless of age and gender, periodically experiences various pains or fever. Analgesic and antipyretic drugs help cope with such symptoms. One of the most popular and safe drugs is Panadol. However, not everyone knows how to use it correctly, so it is worth studying the instructions for use in more detail in order to avoid the most common mistakes made when treating with the drug.

general information

Panadol is a medication that is used to relieve pain of mild or moderate intensity in different locations. This product is produced by the pharmaceutical corporation GlaxoSmithKline Dungarvan LTD (Ireland/Great Britain).

Drug group, INN, application

Panadol tablets belong to a special group of drugs - analgesics-antipyretics. Such drugs are non-narcotic painkillers. They are also able to reduce high body temperature during various colds and infectious diseases that are accompanied by an inflammatory process. Particularly popular are effervescent tablets (Panadol Soluble), which quickly dissolve in water and act much faster than usual.

The international nonproprietary name depends on the active component that is part of the drug and determines its effect. Panadol INN – . The medicine is used to eliminate pain and reduce high body temperature during colds, ARVI and other diseases.

Release form and cost

Panadol is available in tablet form. Each tablet is white in color and cylindrical in shape. On one side it has a special break line, and on the other there is a corporate logo in the form of a triangle. In total, the cardboard box contains 12 such tablets.

You can buy Panadol at any pharmacy, since it is freely available. The retail price of a medicine depends on where it is purchased. Examples of the cost of the drug (for 12 tablets) in different pharmacies in Russian cities:

Many people today are convinced of the convenience and ease of ordering medications from online pharmacies. Such stores offer reasonable prices and also provide fast delivery of goods directly to your home.

Components and their action

The medicine contains the active substance – paracetamol. 1 tablet contains 500 mg. Additional components have an auxiliary effect. Among them are corn starch, gelatin, hypromellose, povidone, talc, triacetin, potassium sorbate, stearic acid.

The pharmacodynamics of the drug depends on the action of its active component. Paracetamol blocks cyclooxygenases (1 and 2), which leads to a decrease in the production of prostaglandins (pain mediators and thermoregulation). This effect is mainly observed in the central nervous system, without affecting the peripheral one. Therefore, this substance does not irritate the intestinal mucosa and does not affect water-salt metabolism.

Paracetamol has the ability to relieve pain and fever, but is not able to relieve inflammation.

Paracetamol is well absorbed from the digestive system. An hour or 2 after oral administration, its maximum concentration is observed. The metabolic process occurs in the liver, where, when interacting with various substances (glucuronic acid, sulfates, glutathione), active and inactive metabolites are formed. The substance is excreted in the form of metabolites (3% unchanged) by the kidneys along with urine. The half-life ranges from 1 to 4 hours.

Many people are interested in what is the difference between regular Panadol and Panadol Extra? The second drug is a type of Panadol, which additionally contains caffeine. It promotes more active absorption of paracetamol and increases its bioavailability.

This significantly enhances the analgesic ability of the drug. In addition, the substance has a tonic effect on blood vessels and provides an additional analgesic effect. But it is worth remembering that hypertensive patients should not take this drug, as it can slightly increase blood pressure.

1 tablet contains 500 mg of paracetamol, as well as additional caffeine (65 mg). The tablets are effervescent, meaning they are dissolved in water before use, which speeds up absorption.

Indications and possible limitations

Panadol is used if there are appropriate indications. So what does the drug help with? It is used for symptomatic relief of pain, which is of weak or moderate intensity and of varying localization. At the same time, it makes it easier:

• pain in the teeth (including after dental procedures);
• headache (tension pain or migraine);
• rheumatic or neuralgic pain in the back;
• muscle pain;
• menstrual pain;
• neuralgic pain in different parts of the body.

The medicine is widely used as an antipyretic for colds and infectious diseases to eliminate fever. The medicine does not affect the progression of the pathology, since it does not have the ability to stop the inflammatory process.

Contraindications are individual intolerance to one or more components, children's age (under 6 years). In these cases, the drug is not used at all. It can be prescribed with extreme caution in the presence of the following conditions:

• hyperbilirubinemia;
• viral hepatitis;
• kidney or liver failure in severe stages;
• lack of glucose;
• alcohol abuse, alcoholic hepatitis or cirrhosis;
• advanced age;
• period of bearing a child;
• lactation period.

In the presence of such conditions, the drug should be taken only under medical supervision. He takes into account the risks, determines the possibility of taking the medicine and prescribes a special dosage regimen.

Panadol is approved for use by pregnant women and nursing mothers. Although its active component paracetamol is able to penetrate the placental barrier and into breast milk, it does not have a negative or dangerous effect on the fetus, the course of pregnancy or the lactation process, and does not harm the baby. But it should be used with caution.

Instructions for use

It is important to use this medicine correctly. This is a drug for internal use. Therefore, the tablets are swallowed whole with liquid. It is also important to follow the dosage:

It is important to remember that you should wait at least 4 hours between doses. Children are given the medicine for no more than 3 days in a row, then consultation with a doctor is required.

Pharmacological interactions

An important point in using Panadol is the possibility of combining it with other medications. Here are some facts about its drug interactions that you should definitely consider:

special instructions

To avoid negative consequences, some features of the drug should be taken into account. Among the special instructions you need to pay attention to the following points:

In some conditions (exhaustion, sepsis, HIV infection), there is a lack of glutathione, which is involved in the metabolism of paracetamol. In this case, the risk of developing metabolic acidosis increases. Its signs are:

• rapid breathing, inability to take a breath;
• nausea;
• attack of vomiting;
• loss of appetite.

If such symptoms appear, you should immediately seek help from a medical facility. Panadol does not affect the reaction rate, so it can be used by vehicle drivers. By following these recommendations, you can reduce the risk of developing negative and potentially life-threatening consequences to a minimum.

Side effects and signs of overdose

As a rule, when taken correctly, the drug is well tolerated. But in some cases, the following negative side effects are possible:

Overdose is quite dangerous, especially if the patient has taken more than 5 g of paracetamol. This can cause liver toxicity. People at risk of such damage include people who:

• taking drugs that stimulate liver enzymes (rifampicin, phenobarbital, primidone and others);
• abuse alcohol;
• they eat irrationally, starve, go on a diet, and are malnourished;
• have severe pathologies that provoke glutathione deficiency (HIV infections, cystic fibrosis).

How to identify paracetamol poisoning? In case of overdose, the patient experiences:

• abdominal pain;
• attack of nausea and vomiting;
• pale skin;
• increased sweating;
• general weakness.

Signs of liver poisoning appear on the 2nd day. In this case, liver failure, pancreatitis, heart rhythm disturbances, and encephalopathy may develop. In the presence of such pathologies, a person falls into a coma. Most often, such life-threatening conditions occur when taking more than 10 g of medication.

What should you do when taking large doses of paracetamol? First of all, regardless of how you feel, you should contact a medical facility. There the patient will be prescribed gastric lavage and absorption agents. Next, it may be necessary to introduce antidotes - methionine and acetylcysteine. This therapy is carried out only in a hospital setting.

Similar drugs

If necessary, replace the medicine with its analogues. Among them the most popular:

Many paracetamol-based medications that help with flu and cold symptoms are available in the form of hot drinks (Theraflu, Multigrip, Pharmacitron, and others). Such drugs also help to warm up and relieve fever.

Examples of drug reviews

To have a complete understanding of the drug, you need to read the reviews about it from doctors and their patients:

Lyaluk S.A., dentist:“If a tooth hurts, it needs to be treated. Of course, you can take Panadol or its analogues. But such medications will only relieve pain temporarily. Of course, sometimes this is necessary. But you shouldn’t get carried away with them.”

Grinchenko V.K., pediatrician:“I admit the possibility of using Panadol. But children should choose special forms (baby syrup, candles). Adult tablets can only be taken from 6 years of age. I recommend to all parents that children should not be given antipyretics or painkillers for more than 3 days in a row. We need to treat the disease, not stop the symptoms.”

Christina, 26 years old: “I take Panadol when I need to relieve pain. It helps me with tooth pain, headaches, and painful periods. I don’t have any negative reactions because I try not to exceed the permissible dosage.”

Valentina, 51 years old:“My problem is frequent headaches. What have I not tried? Sometimes I even had to take light drugs. Yes, they help, but they are addictive. Therefore, I decided to switch to regular Panadol. A good remedy. Inexpensive and very effective. But you shouldn’t get carried away with them either, since the paracetamol contained in it harms the liver.”

Panadol is a popular remedy that is used to relieve pain in various locations. It is also prescribed for colds and flu symptoms. This medicine does not affect the development of an infectious disease, since it is not able to stop the inflammatory process, therefore it should be used only in complex therapy.

Young children with various diseases need special medications and it’s not just a matter of dosage. Some medications are difficult for babies to swallow because of their unpleasant taste. Therefore, the pharmaceutical industry has long been producing medications specifically for children. One of the most common is Panadol syrup. This drug belongs to the group of non-steroidal anti-inflammatory drugs and is used to reduce fever and reduce pain. The drug is relatively safe for children and works effectively.

general characteristics

Panadol syrup is a pain reliever and its main active ingredient is the non-steroidal anti-inflammatory drug paracetamol. It was discovered at the end of the 19th century, but after that it was tested and studied for a long time. The active use of paracetamol began only in the middle of the 20th century, when its safety and effectiveness in reducing fever and pain were proven. This is the most popular non-steroidal anti-inflammatory drug, which is used even to treat small children.

Panadol syrup based on paracetamol is available in the form of a thick suspension. People began to call the drug syrup because of its beautiful pink color and pleasant sweet taste. The suspension is thick, with small inclusions of crystals. It has a pleasant strawberry aroma, so children drink it easily. The drug is available in 100 ml dark glass bottles. Be sure to include a measuring syringe or spoon in the package, which makes it easier to accurately dose the medicine.

Composition of the drug

This medicine is available in different forms: tablets, injection solution, rectal suppositories. But the most popular is Panadol syrup. Its composition is adapted for use from 3 months of age. Therefore, the drug does not contain alcohol, acetylsalicylic acid and sugar.

5 ml of the drug contains 120 mg of paracetamol. This is the optimal dosage to effectively reduce pain and fever, but does not cause side effects. In addition, Panadol contains excipients: malic acid, sorbitol, glucose, citric acid, flavoring.

Why do you need to lower the temperature?

During various viral and bacterial infections, processes occur in the human body that are accompanied by high body temperature. When it increases, blood circulation and metabolic processes accelerate, which helps destroy pathogenic microorganisms. But this condition adversely affects the functioning of the heart and nervous system. Young children have a particularly hard time with elevated body temperatures. They may experience convulsions, disturbances in water-salt balance, and a severe drop in blood pressure. Therefore, the temperature needs to be “lowered.”

But it is recommended to do this when it exceeds 38 degrees. After all, the child’s body learns to resist infection, develops protective mechanisms and immunity. Moreover, now there are many drugs that act quickly. The most common is Panadol syrup. Parents just need to monitor the condition of their sick child and take the temperature more often. Doctors recommend giving antipyretic medicine when the thermometer reaches 38 degrees. But you need to know how long it takes for Panadol syrup to work. Relief from the child’s condition does not occur immediately, but after 20-30 minutes.

Features of the action

The active ingredient of the syrup is paracetamol. It acts by blocking them. It is these substances that are produced in large quantities under the influence of bacteria and viruses. They provoke a rise in temperature and inflammation. In addition, paracetamol affects the thermoregulation center, reducing its excitability. After administration, this substance is quickly distributed throughout the body, entering all tissues and fluids.

Paracetamol has a mild effect and low anti-inflammatory activity. After all, when it enters the gastrointestinal tract, it is quickly destroyed. The drug is excreted by the kidneys and through the intestines within 2-3 hours after administration. But it starts to work within half an hour.

Benefits of use

Compared to other antipyretic and analgesic drugs used for children, Panadol has many advantages:

• begins to act within 20-30 minutes;
• can be used in children from 3 months;
• the temperature is reduced gradually;
• does not damage the mucous membrane of the gastrointestinal tract;
• well tolerated by children;
• has a pleasant taste and aroma;
• lasts about 4 hours;
• Thanks to the presence of a measuring syringe, the drug is convenient to dose and easy to give to children.

Indications for use

One of the most effective painkillers and anti-inflammatory drugs is Panadol syrup. Instructions for use recommend using it to alleviate the child’s condition in the following cases:

• for influenza, ARVI, colds;
• scarlet fever, chickenpox, rubella, measles, mumps;
• to relieve pain during teething;
• for headaches, muscle pain;
• for otitis media, sinusitis, tonsillitis, sore throat;
• to prevent allergic reactions after vaccination.

Contraindications

Despite the relative safety of paracetamol, not all children can take Panadol. It is prohibited to use:

• in case of individual intolerance to the components of the product;
• for blood diseases;
• liver or kidney dysfunction;
• children under 3 months.

Side effects

Usually the drug "Panadol" is well tolerated by the child. But in some cases, allergic reactions or side effects are possible. Most often these are hives, rash and itchy skin. Sometimes bronchospasm and even anaphylactic shock are possible. But to prevent such phenomena, it is necessary not to exceed the recommended dosage. And if after the first dose there are undesirable reactions, the drug should no longer be given to the child.

Sometimes there are side effects such as abdominal pain, nausea, vomiting. In rare cases, anemia and changes in blood composition are possible.

Panadol syrup: instructions for use

This drug is intended for the treatment of children from 3 months to 12 years. It can only be used as prescribed by a doctor. It is acceptable to use the drug once to relieve pain or reduce fever, but then you should still consult a doctor.

The form of release of the drug is very convenient, so parents usually have no questions about how to give Panadol syrup to their child. Before use, shake the liquid in the bottle. Then use a measuring syringe to draw out the required amount of suspension. The same syringe is used to squeeze the drug into the baby’s mouth. After use, it must be rinsed well and dried.

The dosage of the drug is usually prescribed by the attending physician. Most often, the syrup is taken 3-4 times a day, that is, every 4-6 hours. The amount of suspension taken at a time depends on age:

• up to 6 months of age 4 ml;
• up to one year - 5 ml;
• at 1-2 years - 7 ml;
• up to 3 years 9 ml;
• up to 6 years 10 ml;
• 6-9 years 14 ml;
• after 9 years, 20 ml.

But most often the dosage is calculated depending on the child’s weight. It is necessary to give 15 mg per kg of baby's weight. The drug is taken for no more than 3-5 days. If after 2-3 days the temperature does not decrease, you should consult your doctor about choosing another remedy.

Overdose

When taking it, you must strictly adhere to the exact dosage of Panadol syrup. After all, the severity of side effects will be higher if the permissible amount is exceeded. With long-term use or even with a large single dose of the drug, paracetamol poisoning is possible. The first symptoms of this condition are abdominal pain, diarrhea, pale skin, excessive sweating, lethargy, and dizziness.

With prolonged excess of the dosage, chronic poisoning is observed, which is manifested by impaired liver and kidney function. Possible renal colic, nephritis, bacteriuria, progressive encephalopathy, necrosis of liver cells. Blood clotting disorders, thrombocytopenia, bone marrow dysfunction, and low blood sugar may occur. In the most severe cases, coma may occur.

If suspected, gastric lavage is necessary. The child should be given adsorbents, for example, activated carbon, Smecta, Enterosgel or Polysorb. The use of the paracetamol antagonist, acetylcysteine, is also indicated. In serious cases, hospitalization and hemodialysis are necessary.

Special instructions when using the drug

It is very important not to combine Panadol with other non-steroidal anti-inflammatory drugs, especially those containing paracetamol. A child’s body may react inadequately to taking several medications at the same time. For example, when taking anticoagulants, bleeding is possible, and some drugs together with paracetamol have a strong toxic effect on the liver. These are chloramphenicol-based drugs, for example, "Levomecetin", as well as "Difenin", "Rifampicin", "Butadione", "Carbamazepine", as well as barbiturates. Therefore, in the complex treatment of a child, the choice of drugs must be determined by a doctor.

The drug can be given to children only after 3 months of age. For babies born prematurely, its use should only be under medical supervision. Panadol syrup is sometimes used during pregnancy to reduce fever. This remedy is the safest compared to other antipyretic drugs, but you should still consult your doctor first.

Analogues of "Panadol"

The pharmaceutical industry produces many different drugs for children based on paracetamol. They may differ in the dosage of the main active ingredient, the presence of auxiliary components, and the release form. But if it is impossible to use Panadol syrup, you can purchase a similar product to treat your child:

• "Paramol".
• "Aminadol."
• "Paracetamol".
• "Calpol".
• "Tylenol."
• "Daleron."
• "Efferalgan."
• "Cefekon D".

Panadol syrup: reviews

This drug is popular with parents because it effectively relieves pain and copes with high fever. Doctors also highly appreciate the effectiveness of the drug and its good tolerability. This is why Panadol is so often used. Many parents note that children like the syrup and they drink it with pleasure. The drug very rarely causes side effects, but it relieves the baby’s condition well. The advantages of using it also include price. Panadol syrup for children costs about 100 rubles per bottle.

Children's Panadol: instructions for use and reviews

A medicine belonging to the group of non-steroidal anti-inflammatory drugs is Panadol. The instructions for use indicate that 500 mg tablets, Extra with caffeine, Baby suspension or syrup, rectal suppositories are prescribed to reduce elevated body temperature. In addition, this remedy has an analgesic effect.

Release form and composition

Panadol is available in the following dosage forms:

• The tablets are white, capsule-shaped with flat edges and a smooth surface. They are covered with an enteric film coating. The main active ingredient of the drug is paracetamol, its content in one tablet is 500 mg.
• Panadol Extra tablets.
• Oral suspension Children's Panadol Baby (sometimes mistakenly called syrup).
• Rectal suppositories 125 mg and 250 mg (for children).

Paracetamol + caffeine + excipients - composition of Panadol Extra.

Suppositories and syrup for children contain only paracetamol.

Indications for use

What does Panadol help with? The drug is used for symptomatic therapy and pain relief:

• toothache;
• post-traumatic pain;
• migraine;
• algodismenorrhea;
• headache;
• a sore throat;
• pain from burns;
• painful menstruation;
• muscle pain;
• pain in the back, lower back.

As an antipyretic (febrile syndrome), the drug is prescribed for elevated body temperature (cold, flu, infection). The drug does not affect the progression and course of the underlying disease and is used only to reduce the severity of pain symptoms.

Instructions for use

Panadol film-coated tablets should be swallowed without chewing and with plenty of water. Effervescent tablets must be dissolved in 200 ml of water.

• Adults and children over 12 years of age are prescribed 500 mg-1 g (1-2 tablets) up to 4 times a day, if necessary. The interval between doses is at least 4 hours, a single dose (2 tablets) can be taken no more than 4 times (8 tablets) within 24 hours.
• Children aged 6-9 years: 1/2 tablet. 3-4 times/day. The interval between doses is at least 4 hours. The maximum single dose for children 6-9 years old is 1/2 tablet. (250 mg), maximum daily dose - 2 tablets. (1 g).
• Children aged 9-12 years: 1 tablet. up to 4 times/day. The interval between doses is at least 4 hours, a single dose (1 tablet) can be taken no more than 4 times (4 tablets) within 24 hours.

An interval of four hours must be maintained between each use of Panadol. In accordance with the instructions, this product can be taken independently for no more than three days. If after three days of treatment there is no improvement in the condition, you should consult a doctor.

Extra

Adults (including the elderly) and children over 12 years of age are prescribed 1-2 tablets 3-4 times a day, if necessary. The interval between doses is at least 4 hours. The maximum single dose is 2 tablets, the maximum daily dose is 8 tablets.

The drug is not recommended for use for more than five days as an analgesic and for more than three days as an antipyretic without a doctor’s prescription and supervision. Increasing the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician.

Rectal suppositories

Rectally in adults and adolescents weighing more than 60 kg, it is used in a single dose of 500 mg, the frequency of administration is up to 4 times a day. The maximum duration of treatment is 5-7 days. Maximum doses: single - 1 g, daily - 4 g.

• Single oral doses for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg/kg.
• Single doses for rectal use in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg. Frequency of application - 4 times a day with an interval of at least 4 hours.

The maximum duration of treatment is 3 days. Maximum dose: 4 single doses per day.

Suspension or syrup

The drug is taken orally. The contents of the bottle should be shaken well before use. The measuring syringe placed inside the package allows you to dose the drug correctly and rationally. The dose of the drug depends on the age and body weight of the child.

For children over 3 months of age, the drug is prescribed 15 mg/kg body weight 3-4 times a day, the maximum daily dose is no more than 60 mg/kg body weight. If necessary, you can take the drug every 4-6 hours in a single dose (15 mg/kg), but no more than 4 times within 24 hours. Do not exceed the recommended dose.

Duration of use without consulting a doctor: to reduce temperature - no more than 3 days, to reduce pain - no more than 5 days. In the future, as well as in the absence of a therapeutic effect, you should consult a doctor.

Read also: how to take a close analogue for fever for children and adults.

pharmachologic effect

Paracetamol is the main active substance included in the drug. This remedy prevents the formation of inflammatory mediators, including chemical compounds and prostaglandins that provoke an increase in body temperature.

Panadol and other paracetamol-containing drugs are characterized by weak anti-inflammatory activity. This is due to the fact that when paracetamol enters the tissue, cellular enzymes begin to destroy it. The drug has an antipyretic and analgesic effect at the level of the central nervous system. The maximum concentration of the drug in the blood is achieved after 0.5 - 2 hours from the moment of administration.

Paracetamol is broken down in the liver. The drug is eliminated through the kidneys. This product does not upset the balance of electrolytes, does not have a detrimental effect on the mucous membrane of the digestive tract, and does not contribute to fluid retention in the body.

Contraindications

Absolute:

• Hypersensitivity to the components of the drug.
• Age up to 6 years.

Relative (prescribing Panadol requires caution in the presence of the following conditions/diseases):

• Glucose-6-phosphate dehydrogenase deficiency.
• Liver and kidney failure.
• Benign hyperbilirubinemia (including Gilbert's syndrome).
• Viral hepatitis.
• The period of pregnancy and breastfeeding.
• Elderly age.
• Alcoholic liver damage and alcoholism.

Side effects

• Allergic reactions - skin rash and itching, angioedema (severe swelling of the soft tissues of the face and external genitalia).
• Urinary system - interstitial nephritis (inflammation of kidney tissue), nonspecific bacteriuria (the appearance of bacteria in the urine), renal colic (severe spasm of the kidney tubules with the appearance of severe paroxysmal pain in the lumbar region), papillary necrosis (death of the kidney papillae).
• Blood and red bone marrow - a decrease in the number of red blood cells (anemia) and platelets (thrombocytopenia) in the blood, an increase in the concentration of the oxidized form of hemoglobin methemoglobin in the blood (methemoglobinemia).

If signs of side effects appear, you should stop taking Panadol tablets and consult a doctor.

Children, pregnancy and breastfeeding

When used during pregnancy, the active ingredients of the drug penetrate the placental barrier. For this reason, the use of Panadol during pregnancy is not recommended. The drug is prescribed during pregnancy only if the potential risk to the fetus is lower than the benefit to the health of the mother.

In childhood

Contraindication: children under 6 years of age.

special instructions

When prescribing a long course in high doses, the blood picture should be monitored. Panadol is prescribed only under medical supervision and with caution for kidney or liver diseases, simultaneously with antiemetic drugs (metoclopramide, domperidone), as well as with drugs that lower blood cholesterol (cholestyramine).

To avoid toxic liver damage, you should not combine the use of Panadol and alcoholic beverages. In cases where there is a need for daily painkillers, paracetamol, when used in combination with anticoagulants, can be taken only occasionally. The doctor must be warned about taking Panadol in cases of testing to determine the level of glucose and uric acid in the blood.

Drug interactions

The risk of hepatotoxic damage increases with simultaneous treatment with inducers of microsomal liver enzymes and drugs that exhibit hepatotoxic effects. A moderate or slight increase in prothrombin time is recorded.

The absorption of Paracetamol is reduced when anticholinergic medications are prescribed. The severity of the analgesic effect is reduced, and elimination is accelerated when treated with oral contraceptives. Paracetamol inhibits the activity of uricosuric drugs. The bioavailability of Panadol decreases when taking Activated Carbon. A decrease in the excretion of Diazepam is recorded.

Panadol accelerates the elimination of Lamotrigine. Metoclopramide increases the concentration of Paracetamol in the blood, increasing its absorption. Probenecid reduces the clearance of Panadol. The opposite effect is observed with Sulfinpyrazone and Rifampicin. Ethinyl estradiol enhances the absorption of the drug from the intestinal lumen.

Analogues of the drug Panadol

Analogues are determined by structure:

1. Sanidol.
2. Tylenol for babies.
3. Children's Tylenol.
4. Panadol Junior.
5. Xumapar.
6. Ifimol.
7. Tsefekon D.
8. Children's Panadol.
9. Calpol.
10. Paracetamol for children.
11. Daleron.
12. Tylenol.
13. Paracetamol.
14. Febricet.
15. Passed for children.
16. Paracetamol syrup 2.4%.
17. Meksalen.
18. Apap.
19. Strimol.
20. Lupocet.
21. Paracetamol (Acetophene).
22. Perfalgan.
23. Passer.
24. Aldolor.
25. Pamol.
26. Panadol soluble tablets.
27. Akamol Teva.
28. Efferalgan.
29. Acetaminophen.

Vacation conditions and price

The average cost of Panadol (tablets 500 mg No. 12) in Moscow is 49 rubles. The price of the suspension is 98 rubles per 100 ml. Available without a prescription.

Store out of the reach of children at a temperature not exceeding 25 C. Shelf life - 5 years.

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Analgesic-antipyretic

Active substance

Release form, composition and packaging

◊ Oral suspension pink, viscous, with crystals and strawberry scent.

Excipients: malic acid, xanthan gum, maltitol, sorbitol, citric acid, sodium nipasept, strawberry flavor, azorubine, water.

100 ml - dark glass bottles (1) complete with a measuring syringe - cardboard boxes.
300 ml - dark glass bottles (1) complete with a measuring syringe - cardboard boxes.

pharmachologic effect

Analgesic-antipyretic. Has an analgesic and antipyretic effect. Blocks cyclooxygenase in the central nervous system, affecting pain and thermoregulation centers.

The anti-inflammatory effect is practically absent.

It does not affect the state of the gastrointestinal mucosa and water-salt metabolism, since it does not affect the synthesis of prostaglandins in peripheral tissues.

Pharmacokinetics

Suction and distribution

Absorption is high. Paracetamol is quickly and almost completely absorbed from the gastrointestinal tract. Cmax is reached in 30-60 minutes.

Plasma protein binding is about 15%. The distribution of paracetamol in body fluids is relatively even.

Metabolism

Metabolized primarily in the liver with the formation of several metabolites. In newborns in the first two days of life and in children 3-10 years of age, the main metabolite of paracetamol is paracetamol sulfate; in children 12 years of age and older, it is conjugated glucuronide.

Part of the drug (approximately 17%) undergoes hydroxylation to form active metabolites that are conjugated with glutathione. With a lack of glutathione, these metabolites of paracetamol can block the enzyme systems of hepatocytes and cause their necrosis.

Removal

T1/2 when taking a therapeutic dose ranges from 2-3 hours. When taking therapeutic doses, 90-100% of the dose taken is excreted in the urine within one day. The main amount of the drug is released after conjugation in the liver. No more than 3% of the received dose of paracetamol is excreted unchanged.

Indications

Used in children aged 3 months to 12 years:

• to reduce elevated body temperature against the background of colds, flu and childhood infectious diseases (including chicken pox, mumps, measles, rubella, scarlet fever);
• for toothache (including teething), headaches, ear pain with otitis media and with.

In children 2-3 months of age, a single dose is possible to reduce body temperature after vaccination.

Contraindications

• severe liver or kidney dysfunction;
• neonatal period;
• hypersensitivity to paracetamol or any other component of the drug.

WITH caution The drug should be used for liver dysfunction (including Gilbert's syndrome), renal dysfunction, genetic absence of the enzyme glucose-6-phosphate dehydrogenase, severe blood diseases (severe anemia, leukopenia, thrombocytopenia).

The drug should not be taken simultaneously with other paracetamol-containing drugs.

Dosage

The drug is taken orally. The contents of the bottle should be shaken well before use. The measuring syringe placed inside the package allows you to dose the drug correctly and rationally.

The dose of the drug depends on the age and body weight of the child.

Children over 3 months the drug is prescribed at 15 mg/kg body weight 3-4 times/day, the maximum daily dose is no more than 60 mg/kg body weight. If necessary, you can take the drug every 4-6 hours in a single dose (15 mg/kg), but no more than 4 times within 24 hours.

Duration of use without consulting a doctor: to reduce temperature - no more than 3 days, to reduce pain - no more than 5 days.

In the future, as well as in the absence of a therapeutic effect, you should consult a doctor.

Side effects

From the digestive system: sometimes - nausea, vomiting, pain in the stomach.

Allergic reactions: sometimes - itching, urticaria, Quincke's edema.

From the hematopoietic system: rarely - anemia, thrombocytopenia, leukopenia.

Overdose

Symptoms acute paracetamol poisoning: nausea, vomiting, stomach pain, sweating, pale skin. After 1-2 days, signs of liver damage are determined (pain in the liver area, increased activity of liver enzymes). In severe cases, liver failure, encephalopathy and coma develop.

Treatment: Stop taking the drug and consult a doctor immediately. It is recommended to lavage the stomach and take enterosorbents (, polyphepan). The specific antidote for paracetamol poisoning is acetylcysteine.

In case of accidental overdose, seek immediate medical attention, even if the child feels well.

Drug interactions

When used together with barbiturates, diphenin, anticonvulsants, rifampicin, butadione, the risk of hepatotoxicity may increase.

When taken simultaneously with chloramphenicol (chloramphenicol), the toxicity of the latter may increase.

The anticoagulant effect of warfarin and other coumarin derivatives may be enhanced by long-term regular use of paracetamol, which increases the risk of bleeding.

special instructions

Children from 2 to 3 months and children born prematurely can be given Children's Panadol only as prescribed by a doctor.

When conducting tests to determine uric acid levels and serum levels, the physician must be aware of the patient's use of Children's Panadol.

Use in childhood

The drug is contraindicated during the neonatal period.

Storage conditions and periods

The drug should be stored in a place protected from light, out of reach of children, at a temperature not exceeding 30°C; do not freeze. Shelf life - 3 years.