Temperature due to lycopid in a child. Likopid (the latest generation immunomodulator): reviews from immunologists. Indications for use

"Likopid" is an immunomodulator. It stimulates the activity of netrophils and promotes the production of antibodies.

This drug has a wide spectrum of action, so it is prescribed for the treatment of a wide variety of diseases.

Indications for use

"Likopid" helps treat the following diseases and conditions (from which):

• Hepatitis B
• Viral hepatitis A
• Oral herpes
• HPV (human papilloma virus)
• Purulent processes in soft tissues and skin
• Inflammatory processes in soft tissues that develop as a result of surgery
• Psoriasis
• Pulmonary tuberculosis
• Pneumonia
• Pulmonary edema.

Compound

The drug contains the following substances:

• Glucosaminylmuramyl dipeptide (active ingredient)

Additional substances:

• Sucrose
• Lactose.

Medicinal properties

"Licopid" is an immunomodulator that stimulates the synthesis of special antibodies, enhances tumor necrosis and suppresses bactericidal activity.

After taking this drug, it increases the activity of killer cells. Tablets have a bioavailability of 15%. The withdrawal time is five hours.

The immunomodulator is excreted unchanged by the kidneys and urine.

Average price from 300 to 1300 rubles.

Release forms

"Likopid" is produced in the form of white round tablets. Without smell.

The dosage of one tablet is 10 mg of the substance. 1 blister contains 10 tablets. 1 package contains 1 or two blisters.

Mode of application

The drug is taken orally. For the best effect, you need to drink it half an hour before meals.

The dosage regimen and dosage are selected by the attending physician depending on the disease, age and condition of the patient.

Before surgery, this medicine is used at a dose of 1 mg once a day. The duration of the course is 10 days.

For severe inflammatory and purulent skin processes, 2 mg is prescribed three times a day. The duration of therapy is seven days.

For chronic infectious diseases of the lungs and nasopharynx, you need to take 5 mg of medication per day. Duration of treatment – ​​10 days.

For psoriasis, HPV and infections caused by the herpes virus, you should take 2 mg twice a day for six days.

Children over the age of three years can be prescribed the drug, but only when the disease progresses rapidly and is difficult to treat with other drugs. The acceptable daily intake for children is 1 mg once a day. The course of therapy and its duration is determined by the supervising physician.

Children aged ten to sixteen years can use the drug at a dose of 2 mg per day. The duration of treatment should be no more than ten days. During this time, the child must be under medical supervision.

During pregnancy and breastfeeding

"Licopid" is not prescribed during pregnancy, since its active substance can harm the baby in the womb.

The drug can be used during lactation only if breastfeeding is discontinued. This must be coordinated with the attending physician, because only he can make the right decision about the need for therapy.

Contraindications

Tablets are not used to treat HPV and other diseases for the following indications:

• Pregnancy
• Lactation period
• Hyperemia accompanied by high body temperature
• Autoimmune thyroiditis
• Lactose deficiency.

Also, "Likopid" is not prescribed for children under three years of age.

Precautionary measures

Likopid tablets are prescribed with caution for psoriasis and HPV if the patient has:

• Kidney failure
• Diabetes
• Diseases of the circulatory system
• Severe diseases of the cardiovascular system
• Alcohol addiction.

It is important to know that this immunomodulator and alcohol are not compatible, as this can cause unwanted symptoms in the patient.

Interaction with other drugs

"Likopid" should not be combined with tetracyclines and sulfonamides.

When taken simultaneously with fluoroquinolone and cephalosporin antibiotics, it reduces the effect of the latter.

When used together with antiviral drugs, their therapeutic effect is enhanced.
When combined with corticosteroids, this immunomodulator partially loses its therapeutic effect.

Side effects

As a rule, the drug is tolerated quite well. Sometimes patients may develop hyperemia, but this is not an indication for discontinuation of the immunomodulator.

Additional side effects:

• Diarrhea
• Nausea
• Indigestion, loss of appetite
• Drowsiness and weakness
• Sleep disturbance.

Overdose

To date, there is no accurate information about the symptoms of overdose. It is expected that in case of overdose the patient will experience increased side effects.

Treatment of overdose is carried out depending on the observed symptoms. As a preventive measure in case of overdose, it is recommended to rinse the stomach and take sorbents.

Conditions and shelf life

The immunomodulator should be stored in a dry and dark place at temperatures up to 25 degrees Celsius.

Shelf life: 5 years from the date of manufacture indicated on the package. Do not use after expiration date.

Analogs

"Likopid" has the following medicinal analogues:

Lek, Slovenia
Price from 264 to 350 rub.

Active ingredient: Echinacea purple herb juice. Release form: tablets, oral solution.

pros

• Immunomodulator, the composition of which is based on natural ingredients
• Strengthens the body's defenses
• Can be used for children over one year old

Minuses

• May cause dizziness
• The immunomodulator is contraindicated for leukemia and tuberculosis.

Deutsche Homeopathy-Union, Germany
Price from 615 to 780 rubles.

Active ingredient: interferon. Release form: tablets.

pros

• Accelerates the healing process in infectious diseases (tonsillitis, otitis media, sinusitis)
• Can be given to a child under one year old

Minuses

• May cause allergies
• The child should not take it for too long.

Pharmaklon, Russia
Price from 300 to 5000 rub.

Active ingredient: interferon gamma. Available in tablets and powder in a bottle for the preparation of intranasal and injection solutions of 30 and 50 mg.

pros

• It has different release forms, so it can be used to treat various diseases (HPV, herpes, psoriasis).
• Has a broad immunomodulatory effect

Minuses

• Contraindicated during pregnancy as it may harm the baby
• Contraindicated in diabetes mellitus and autoimmune diseases.

« »

NizhPharm, Russia
Price from 500 to 1050 rub.

Yellow tablets with the active ingredient tilorone.

pros

• Has a pronounced immunomodulatory effect
• Helps treat HPV
• Well absorbed from the gastrointestinal tract

Minuses

• Contraindicated in case of sucrose intolerance
• Cannot be used to treat children.

Content

According to the accepted classification, Lykopid is a drug for stimulating the immune system, the action of which is aimed at normalizing the body’s defenses. This effect is provided by the active substance of the composition - glucosaminylmuramyl dipeptide. The drug is produced by the Russian pharmaceutical company Peptek. Read the instructions for using the product.

Composition and release form

Instructions for use of Licopid indicate the composition of the drug. It comes in tablet format. Their description and packaging:

pharmachologic effect

Lykopid has immunomodulatory properties, the active component enters the body and binds to specific centers of the endoplasm of T-lymphocytes and phagocytes. This leads to stimulation of phagocytic type activity in macrophages, neutrophils, and an increase in their cytotoxic and bactericidal activity. Under the influence of the medication, the proliferation of B-lymphocytes increases and specific antibodies are produced. The medicine stimulates antitumor immunity.

Pharmacodynamics and pharmacokinetics

The use of the drug activates the synthesis of tumor necrosis factors, interleukins 1, 12 and 6, gamma interferons, and the production of colony-stimulating factors. Under the influence of the active component of the composition, the performance of killer cells increases. Once inside, the active component is detected in maximum concentration after 1.5 hours and has 10% bioavailability. Glucosaminylmuramyl dipeptide (GMDP) weakly binds to albumin and is metabolized without the formation of active metabolites. The half-life is 4.5 hours, excreted in the urine.

Indications for use

The tablets can be used in the complex treatment of diseases associated with secondary immunodeficiencies. The instructions highlight the indications:

• chronic lung infections;
• herpes infection, ophthalmoherpes;
• papillomavirus infection;
• acute or chronic purulent-inflammatory diseases of soft tissues, skin, postoperative complications, trophic ulcers;
• chronic viral hepatitis B or C;
• pulmonary tuberculosis;
• psoriasis, including arthropathic form.

Directions for use and dosage

According to the instructions, the tablets are taken sublingually (dissolve under the tongue) or orally on an empty stomach 30 minutes before meals. Likopid for adults to prevent complications after surgery is prescribed 1 mg once a day for 10 days. When treating purulent-septic processes of moderate severity, you can take 2 mg 2-3 times a day for a ten-day course, severe - 10 mg once a day for the same course.

If the patient has a chronic respiratory disease, tablets are taken 1-2 mg once a day for 10 days, for tuberculosis - 10 mg once a day in the same course. Mild forms of herpetic infection are treated with 2 mg 1-2 times a day for six days, severe forms - 10 mg 1-2 times a day. For ophthalmoherpes, tablets are taken 10 mg twice a day for a three-day course, after three days treatment repeat.

To eliminate the human papillomavirus that has infected the cervix, Lykopid is taken 10 mg once a day for 10 days. For the treatment of psoriasis, 10-20 mg is prescribed 1-2 times a day for a ten-day course, followed by the use of 10-20 mg every other day. If psoriasis is severe or arthropathic, you need to take 10 mg orally twice a day for a three-week course. During the period of remission, only Likopid is taken; in case of exacerbation, complex treatment is used.

special instructions

According to the instructions, taking the tablets does not affect the decrease in concentration and reaction speed, so treatment can be carried out while driving vehicles or dangerous mechanisms. Likopid increases the effectiveness of antifungal, antibacterial, antiviral drugs, reduces the duration of treatment and the dosage of chemotherapy. While carrying a child or breastfeeding, the use of the medication is contraindicated.

Lykopid for children

The immunomodulator Likopid can be used by children from one year of age. Up to 16 years of age, the use of tablets at a concentration of 1 mg is indicated. For the treatment of infections of the ENT organs and inflammatory skin diseases, take 1 mg once a day for 10 days, for the treatment of herpes - 1 mg three times a day for the same course. To eliminate viral hepatitis, the use of 1 mg three times a day for a 20-day course is indicated. For newborns suffering from pneumonia, enterocolitis, bronchitis, sepsis, you can use 500 mcg twice a day for 7-10 days.

Drug interactions

According to the instructions, Likopid is not advisable to prescribe simultaneously with tetracycline antibiotics and sulfonamide drugs. When combined with penicillins, cephalosporins, fluoroquinolones or polyene derivatives, synergism (increased) action is observed. Antacids and enterosorbents can reduce the bioavailability of the drug, and cytotoxic drugs and glucocorticosteroids can reduce the effectiveness.

Lycopid and alcohol

The instructions do not say on the pages what the body’s reactions are to the combination of Lykopid and alcohol. In the presence of immunodeficiency (indications for use of the drug), alcoholic beverages are contraindicated. A small one-time portion of ethanol will not affect the treatment, but if it is abused, it can result in complete neutralization of the beneficial effect of the medicine.

Side effects

The only side effect from using Lykopid is a short-term increase in body temperature up to 38 degrees. This negative reaction goes away without additional treatment; if it occurs, there is no need to stop the drug. To date, not a single case of drug overdose is known, but exceeding the permissible dose is not recommended.

Contraindications

There are several contraindications for which the use of the drug is strictly prohibited. The instructions include:

• exacerbation of autoimmune thyroiditis;
• pregnancy, breastfeeding period;
• diseases caused by hyperthermia, high body temperature or fever;
• hypersensitivity to the ingredients of the composition, individual intolerance or allergy.

Terms of sale and storage

The medication is a prescription drug and must be stored at temperatures up to 25 degrees for five years.

Analogs

The drug can be replaced with drugs with the same immunomodulatory properties and a similar or different composition. Drug analogues include:

• Immunal – drops and tablets based on Echinacea purpurea juice;
• Anaferon – tablets, drops based on purified antibodies to interferon gamma;
• Broncho-Munal – capsules containing lyophilized bacterial lysate;
• Immunex – syrup with echinacea extract;
• Ismigen - sublingual tablets based on bacterial lysates;
• Ribomunil - immunomodulatory tablets, granules for preparing a solution based on bacterial ribosomes;
• Thymogen - spray, ampoules, cream containing alpha-glutamyl tryptophan;
• GMDP is a structural analogue of Lykopid, completely similar in composition and action.

Lykopid or Polyoxidonium – which is better?

A well-known substitute for Lykopid, Polyoxidonium, has a triple effect - immunostimulating, antioxidant and detoxifying. Its active component azoximer bromide is effective in preventing flu and colds. The drug is presented in the format of suppositories, injections and tablets. Injections are the most effective. It is up to the doctor to decide which medication is best.

Lycopid price

The medication is sold in pharmacies and online at a cost depending on the concentration of the active ingredient and the number of tablets in the pack. Approximate prices for the product and its analogues in Moscow:

Name of the medicine	Internet price, rubles	Pharmacy cost, rubles
Likopid tablets 1 mg 10 pcs.
Likopid tablets 10 mg 10 pcs.
Immunal drops 50 ml
Anaferon children's tablets 20 pcs.

Walking in the fresh air has a beneficial effect on the child's health, but some parents are afraid to let their baby go outside due to weak immunity. Immunostimulating drugs will help break this vicious circle - one of them is Likopid.

Likopid is a new generation immune activator.

Compound

The main active ingredient of Lykopid is glucosaminylmuramyl dipeptide. This is a small fragment of the bacterial wall that causes respiratory diseases in children and adults. Manufacturers also included in the tablet:

• calcium stearate;
• potato starch;
• lactose monohydrate;
• methylcellulose;
• sucrose.

Excipients give the drug a pleasant taste and improve the penetration of glucosaminylmuramyl dipeptide through the oral mucosa.

Tablets with a pleasant taste.

Principle of action - how Lykopid strengthens the immune system

When viruses enter the body, it mobilizes all its forces to fight the infection and begins to produce special cells. They destroy the shell of microorganisms, disrupt their vital functions, thereby destroying them. This process is called an immune response. However, with weak immunity, you may not get a decent response, so doctors use:

• immunostimulants;
• immunomodulators.

After swallowing the tablet, a huge amount of bacterial fragments of infectious agents enter the bloodstream. There is no threat to the baby’s health, because the bacterium has long been dead and cannot reproduce. But the body perceives these fragments as an attack of foreign elements. There is a persistent increase in immunity - if a real virus or bacteria now enters the body, they will be destroyed with the help of special phagocyte cells.

The drug solves the problem of frequent colds.

Indications - when to take the medicine

Only a pediatrician can prescribe this immunomodulator for the prevention or treatment of colds.

Doctors advise using Likopid for children as a means to help protect them from viral infections. The drug allows the child’s body to produce antibodies to many infectious diseases - taking it in a timely manner will help avoid treatment altogether.

The medicine should be taken by children with weak immune systems. It is not difficult to recognize such babies: within one month they can get sick two or more times. The drug will help the child adapt to the community, where epidemics of viral diseases often occur.

The medicine will help children not get sick during the epidemic.

• bronchitis;
• flu;
• furunculosis, pyoderma;
• acute respiratory viral infection.

The use of an immunomodulator to treat a child will help eliminate the symptoms of the disease and prevent it in the future.

Manufacturer and average cost of the drug

Likopid was developed by Russian scientists and is produced in our country by Peptek JSC.

The average price of a 1 mg package of the drug is 220 rubles.

Release forms

Likopid is sold in pharmacies in two dosage forms:

• For children - 1 mg, 10 tablets.
• For adults - 10 mg, 10 tablets.

Primary packaging is a foil blister with cells for tablets.

Secondary packaging - cardboard box with included instructions for use.

How to take the medicine correctly: dosages

To prevent influenza and acute respiratory infections, children from 1 year of age are prescribed 1 tablet at a dose of 1 mg per day before meals or half an hour after meals. And for treatment, the doctor will select the dosage individually for each child.

Only the doctor decides on the prescription of Lycapid for infants.

In severe cases of the disease, 2 tablets at a dose of 1 mg are prescribed daily for 5 days.

If the child only has a stuffy nose and does not have a high fever, then it is enough to give 1 tablet a day at the same time for 10 days.

It is best to take Likopid sublingually, i.e. You need to put the tablet under your tongue and keep it there until it completely dissolves. But little fidgets are unlikely to cope with such a test; they will want to roll the medicine around in their mouths or chew it into pieces. Therefore, parents resort to a trick: the tablets are crushed and mixed with a small amount of milk or fruit puree. This does not affect the effectiveness of the drug - it is completely absorbed in the stomach.

Which children should not take Likopid?

Children should not take Lykopid if they have hypersensitivity to sucrose or lactose. It is extremely rare for a person to develop intolerance to the main substance - glucosaminylmuramyl dipeptide.

The immunologist will not prescribe the drug to children who have a history of illness:

• autoimmune thyroiditis;
• metabolic disorders.

The use of Lykopid is strictly prohibited in case of elevated temperature in a child.

A weakened body may not be able to cope with the additional load that will arise during the production of antibodies. At this time, all forces are mobilized to fight the disease; there is no need to burden him even more.

Possible side effects

Often, the baby’s body responds to the prophylactic administration of Lykopid by increasing body temperature. This is an expected reaction, so there is no need to stop the drug. If the thermometer records a temperature above 38°C, then taking Lykopid is contraindicated for the child and consultation with a specialist is required.

When taking tablets, a short-term increase in body temperature is possible.

Compatibility with other drugs

Pediatricians recommend taking Licopid separately from any medications. Many colds are accompanied by intoxication, and parents give the child adsorbents that will bind and remove the immunomodulator from the body. It is better to wait for recovery and then engage in prevention.

In the presence of immunomodulators they act more strongly. This is not always advisable, so it is better to take antimicrobial drugs and Lykopid at different times.

Analogs of Lykopid: is there a worthy replacement?

There are no drugs with the same composition as Lykopid. If a child has contraindications for taking this immunomodulator or the medicine could not be purchased, then you can select drugs with a similar effect. Here's a quick overview of them:

• Polyoxidonium. An immunomodulator, available in the form of a solution for topical use or injection, tablets and suppositories. The solution can be used to treat children from 6 months. The price per package is 450 rubles.
• Broncho-munal. To increase immunity in children from 6 months use the drug in a dosage of 3.5 mg. Packaging price - 400 rubles.
• Imunorix. Immunomodulator for children from 3 years old. The price per package is 830 rubles.
• Cycloferon. Immunostimulant. The restriction on the use of the drug is children under 4 years of age. Price per package - 190 rubles.
• Isoprinosine. Immunostimulant and antiviral drug. Designed for children over 3 years old. The price per package is 1200 rubles.
• Ismigen. The drug improves immunity in children over 3 years old. One package can be purchased for 550 rubles.

The number of outbreaks of seasonal and cold diseases is steadily growing every year. Such illnesses become especially dangerous for children with weakened immune systems. To avoid frequent colds and viral diseases, experts recommend taking medications that help strengthen the body's protective functions. The most popular medication in this area is a drug called Lykopid.

The product showed a positive effect not only as a preventive measure for various acute respiratory infections and acute respiratory viral infections, but also for reducing the relapses of many chronic diseases.

The effect of the drug on the human body

According to the instructions, the beneficial effect of Lykopid is due to the stimulation of the phagocytic activity of leukocytes, macrophages and monocytes. This means that the above components destroy harmful cells that have entered the body. In addition, a complex of special additives activates the body’s own cells to fight viruses, which significantly strengthens the immune system.

The drug does not cause any side effects, and its use does not harm even very young children.

The medicine contains peptides synthesized from living bacteria - GMDP, which are an analogue of the cells of the body's own immune system, and have a similar operating principle. Thus, Lykopid works as a trigger that activates all protective functions in the human body. In addition to the fact that the drug prevents the formation and development of inflammatory processes, it helps to destroy harmful fungi, bacteria and viruses.

The medicine also contains protein-peptide molecules - cytokines, which perform several useful functions in the body:

• prolong the viability of immune cells;
• promote the active reproduction of antibodies in the body;
• create new white blood cells that help eliminate harmful bacteria that enter the body from the outside;
• improve the functioning of the immune, nervous and endocrine systems.

Likopid: reviews from immunologists

Due to the fact that this medicine activates all possible forms of protection: the body’s humoral and cellular immunity, as well as phagocytosis, the attitude of specialists towards the drug is very positive. In addition to strengthening the body's protective functions, the product is an excellent immunomodulator. It is prescribed for any form of immune deficiency in both adults and children.

Indications for use

• chronic and acute diseases of the respiratory system;
• viral hepatitis C and B;
• human papillomavirus infections;
• purulent viral inflammation of soft and mucous tissues;
• various forms and localizations of psoriasis and herpes.

Also, the instructions for use of Lykopid indicate a number of diseases in which the use of the drug will help to significantly reduce the severity of symptoms and alleviate the overall course of the disease. Such diseases include:

• chronic form of rhinitis, laryngotracheitis, pharyngitis, laryngitis;
• tuberculosis;
• ophthalmic, simple and genital herpes;
• arthropathic psoriasis.

The drug is also prescribed in case of frequent colds and herpes in children or adults. For bronchitis, pneumonia, long-term non-healing wounds, and also as a prevention of complications after surgery, Lykopid also shows a very positive effect.

Likopid for children - features of administration

Instructions for use of Licopid allow the drug to be taken by children over the age of one year. Despite this, many pediatricians prescribe the drug even to infants and newborns. The reason for this is that the medication does not contain harmful chemical compounds that can harm the baby’s health. And GMDP peptides, in small quantities, are even found in breast milk.

Despite the minimum side effects and the safety of the medication for very young children, the drug should only be given to children over one year old. Otherwise, the appointment should be carried out only after appointment and under the close supervision of a specialist.

Many parents are wondering what is better to give to children with a weakened immune system to improve health, Lykopid or its more common interferon-based analogues?

Clinical trials have shown the high effectiveness and absolute safety of the drug Likopid for children of preschool and primary school age. Therefore, for the drug Likopid, reviews from immunologists are almost unambiguous: this is the most suitable drug for strengthening the child’s immune system.

Many parents are also well aware of the problem of increased frequency of colds when visiting preschool institutions.

This happens due to the fact that the child’s still fragile immune system cannot fight back the numerous bacteria and viruses that it encounters when visiting kindergarten. The drug Likopid will help strengthen the baby’s immunity and resist many childhood diseases.

Contraindications for use

Likopid should not be taken in case of acute intolerance to one of the components included in the medication or GMDP. It would also be inadvisable to prescribe Licopid for diseases accompanied by elevated (above 38°C) body temperature, chills, fever and excessive sweating. In case of exacerbation of autoimmune diseases, such as thyroiditis, use is possible only after consultation with a specialist. During pregnancy and breastfeeding, the drug should be taken only after a doctor's prescription and under his strict supervision.

Contraindications for taking Lykopid also include the presence of ailments such as lactose deficiency and galactosemia.

Likopid in combination with other drugs

In combination with most medications, Likopid does not change its effect or their effects, so they are often prescribed in combination. A number of studies have shown that some antiviral and antifungal agents, as well as antibiotics, in combination with Lykopid show greater effectiveness in treatment.

But combination with sorbents and antacid drugs can reduce the absorption and effect of Lykopid. Therefore, they should be taken at different times.

How to take Lykopid

Release form: white round tablets in a dosage of 1 or 10 mg of the drug. Adults are recommended to take the drug at a dosage of 10 mg sublingually. Children's Lykopid (1 mg) can be dissolved in a small amount of water or given whole if the child can take it in this form.

The average duration of the treatment course is up to 10 days. The course can be repeated in the future. How much the drug needs to be taken and in what dosage is determined by the specialist strictly individually.

For better absorption and effectiveness, the medicine is taken on a completely empty stomach or 2 hours after eating.

Taking the drug for various ailments:

• for inflammatory processes and skin suppuration - a daily dose of the drug is 2-3 mg. Severe forms of the disease require increasing the dose to 10 mg;
• papillomavirus - up to 10 mg per day;
• strengthening the immune system after surgery - 2 mg per day;
• when treating psoriasis, Lykopid should be taken 10-20 mg per day for 7-10 days. In the future, the course must be repeated at 10-20 mg every two days. In especially advanced cases, the course of therapy can last up to 20 days;
• simple forms of herpes are treated by taking 2 mg of medication 1-2 times a day. More severe forms require increasing the dosage to 10-20 mg per day. The course duration is usually one week;
• if you have ophthalmoherpes, the medicine must be taken 20 mg per day for at least three days in a row. After a short break of 2-3 days, the course should be repeated;
• for acute and chronic diseases of the respiratory system - the medicine is taken once a day, 2 mg;
• tuberculosis - 10 mg once a day.

Features of taking Likopid in children

For pneumonia, laryngitis, bronchitis and rhinopharyngitis, the medicine is taken in a dosage of 1 mg 2 times a day. For hepatitis C and B, as well as herpes or inflammatory skin diseases - 1 mg up to 3 times a day.

Dosages shown are for guidance only. The exact duration and frequency of taking the drug is determined by the doctor, taking into account the general state of health and the form of the disease.

Possible side effects

In some cases, after taking the drug, body temperature may rise to 37.5 °C. This effect is normal and does not require taking antipyretics. Body temperature usually drops on its own, within several hours after taking the medicine, and does not affect the general well-being of both the adult and the child.

If your body temperature rises above 38.0°C, you should take an antipyretic drug and consult your doctor about further use of Lykopid. This side effect is extremely rare (approximately 0.01% of people) and most often does not require discontinuation of Lykopid.

Sometimes an allergic reaction may occur after taking the drug. Typically, allergy symptoms are noted to sucrose, which is part of the drug.

In rare cases, pain in the joints or muscles appears after taking the medication. Such indicators are not critical and do not require discontinuation of the immunomodulator. Only if pain increases or persists for a long time, you should stop taking the drug and consult a doctor.

A little about analogues

Today, there are no drugs on the domestic market that can compete with Likopid in their composition and amount of active substance. There are a number of drugs that have similar therapeutic effects and similar immunomodulatory effects. For example, in its ability to strengthen the immune system, Likpid is often compared with echinacea, but in its medicinal qualities it is significantly inferior.

Lykopid has a number of therapeutic effects that have a beneficial effect on human health, with virtually no side effects. The positive qualities of Lykopida are also proven by the fact that in 1996, he was awarded the Russian Government Prize in the field of development of technology and science.

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1. 4795 views

   I have always been skeptical about immunomodulators. But when my frequently ill child was prescribed Lykopid 1 mg, I decided to try it. I was amazed by the effect. When he was 4 years old, he was sick almost every month with colds, tonsillitis, and rhinitis. We didn’t get out of illness. And after Lykopid we almost never get sick, and now these endless snot are over!

A good immunomodulator Lykopid. The children were sick non-stop. The pediatrician prescribed Likopid 1 mg. We drank it for 1 month. We haven’t been sick for many months now; we didn’t even get sick in the spring. In the fall we will carry out preventive maintenance for 10 days. The doctor recommended it.

My five-year-old child has been sick for about two years now. I suffered from sore throats very often. And so, ARVI, acute respiratory infections almost every month. During the consultation, the doctor suggested taking the immunomodulator Lykopid in a dosage of 1 mg. Initially, the course is 1 month. Tolerated it well, without adding an increase in temperature (listed in the instructions as a side effect). Then, to consolidate the result, she prescribed drinking for another 10 days. These are sweetish lozenges.
After this treatment of our weak immunity, we almost stopped getting sick. Even somehow fantastic, because... We were sick most of the time and went to the garden during breaks. They forgot about sore throats. It is rare to have a slight runny nose that goes away quickly. We are so excited about the restoration of our immunity!

After spending time with my child in an infectious disease hospital with double pneumonia last year, I decided that I’d stop joking and need to do something about the immune system. After discharge, the attending physician prescribed us a regimen to strengthen the immune system: Lykopid 1 mg for 10 days and vitamins to boost immunity in courses every six months. We drank Vitamishki. They are tasty. Lykopid, by the way, turned out to be surprisingly tasty too. My immunity really improved after this. Now we will take another course before the New Year.

But I liked that you only need to take pills for 10 days and that’s enough to strengthen your immune system. My son drank that much and stopped getting sick often. But I don’t believe in all the drops or pills that you need to take for months, because I tried it and it didn’t give any effect. But the doctor said we still need to wait. So how long can you wait if it’s not there and you want your child to stop constantly catching colds. Now I trust Likopid, we were prescribed a dosage of 1 mg, we drank according to the regimen prescribed by the doctor. There is nothing complicated, but it helps well.

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Immunomodulator

Active substance

Glucosaminylmuramyl dipeptide (GMDP)

Release form, composition and packaging

Pills white, round, flat-cylindrical, with a chamfer and a notch.

Excipients: lactose monohydrate - 184.7 mg, sugar (sucrose) - 12.5 mg, potato starch - 40 mg, methylcellulose - 0.3 mg, calcium stearate - 2.5 mg.

10 pieces. - contour cellular packaging (1) - cardboard packs.

pharmachologic effect

Pharmacodynamics

The active ingredient of Lykopid tablets is glucosaminylmuramyl dipeptide (GMDP) - a synthetic analogue of the structural fragment of the membrane (peptidoglycan) of bacterial cells. GMDP is an activator of innate and acquired immunity, strengthens the body’s defense against viral, bacterial and fungal infections; has an adjuvant effect in the development of immunological reactions.

The biological activity of the drug is realized through the binding of GMDP to the intracellular receptor protein NOD2, localized in the cytoplasm of phagocytes (neutrophils, macrophages, dendritic cells). The drug stimulates the functional (bactericidal, cytotoxic) activity of phagocytes, enhances their presentation of antigens, the proliferation of T- and B-lymphocytes, increases the synthesis of specific antibodies, and helps normalize the balance of Th1/Th2 lymphocytes towards the predominance of Th1. The pharmacological action is carried out by enhancing the production of key interleukins (interleukin-1, interleukin-6, interleukin-12), TNF alpha, interferon gamma, colony-stimulating factors. The drug increases the activity of natural killer cells.

Lykopid has low toxicity (LD 50 exceeds the therapeutic dose by 49,000 times or more). In the experiment, when administered orally in doses 100 times higher than the therapeutic dose, the drug does not have a toxic effect on the central nervous system and cardiovascular system, and does not cause pathological changes in internal organs.

Lykopid does not have embryotoxic or teratogenic effects and does not cause chromosomal or gene mutations.

Experimental studies conducted on animals provided data on the antitumor activity of the drug Lykopid (GMDP).

Pharmacokinetics

The bioavailability of the drug when taken orally is 7-13%. The degree of binding to blood is weak. The time to reach Cmax is 1.5 hours after administration. T 1/2 - 4.29 hours. Does not form active metabolites, is excreted mainly through the kidneys unchanged.

Indications

The drug is used in adults in the complex treatment of diseases accompanied by secondary immunodeficiency states:

• acute and chronic purulent-inflammatory and soft tissues, including purulent-septic postoperative complications;
• sexually transmitted infections (human papillomavirus infection, chronic trichomoniasis);
• herpetic infection (including ophthalmoherpes);
• psoriasis (including);
• pulmonary tuberculosis.

Contraindications

• hypersensitivity to glucosaminylmuramyl dipeptide and other components of the drug;
• pregnancy;
• lactation period (breastfeeding);
• children under 18 years of age;
• autoimmune in the acute phase;
• conditions accompanied by febrile temperature (>38°C) at the time of taking the drug;
• rare congenital metabolic disorders (alactasia, galactosemia, lactase deficiency, sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption);
• use for autoimmune diseases is not recommended due to the lack of clinical data.

Lykopid 10 mg carefully used in elderly people, strictly under the supervision of a doctor.

Dosage

Likopid is taken orally on an empty stomach, 30 minutes before meals.

If you miss a dose, if passed no more than 12 hours from the scheduled time, the patient may take the missed dose; in case it has passed more than 12 hours from the scheduled time of administration, you must take only the next dose according to the schedule and not take the missed one.

Purulent-inflammatory diseases of the skin and soft tissues, acute and chronic, severe, including purulent-septic postoperative complications:

Herpetic infection (recurrent course, severe forms): 10 mg 1 time/day for 6 days.

For ophthalmoherpes: 10 mg 2 times/day for 3 days. After a break of 3 days, the course of treatment is repeated.

Sexually transmitted infections (human papillomavirus infection, chronic trichomoniasis): 10 mg 1 time/day for 10 days.

Psoriasis: 10–20 mg 1 time/day for 10 days and then five doses every other day, 10–20 mg 1 time/day.

For severe psoriasis and extensive damage (including psoriatic arthritis): 10 mg 2 times/day for 20 days.

Pulmonary tuberculosis: 10 mg 1 time/day for 10 days.

Side effects

Often (1–10%)- arthralgia (joint pain), myalgia (); at the beginning of treatment, there may be a short-term increase in body temperature to subfebrile values ​​(up to 37.9°C), which is not an indication for discontinuation of the drug. Most often, the side effects described above are observed when taking Lykopid tablets in high doses (20 mg).

Rarely (0.01-0.1%)- short-term increase in body temperature to febrile values ​​(>38.0°C). If body temperature rises >38.0°C, antipyretics can be taken, which does not reduce the pharmacological effects of Lykopid tablets.

Very rarely (<0.01%) - diarrhea.

If any of the side effects indicated in the instructions worsen or the patient notices any other side effects, the doctor should be informed.

Overdose

Cases of drug overdose are unknown.

Symptoms: Based on the pharmacological properties of the drug, in case of overdose, a rise in body temperature to subfebrile (up to 37.9 ° C) values ​​may be observed.

Treatment: If necessary, symptomatic therapy (antipyretic drugs) is carried out and sorbents are prescribed. A specific antidote is unknown.

Drug interactions

The drug increases the effectiveness of drugs, there is synergy with antiviral and antifungal drugs.

Antacids and sorbents significantly reduce the bioavailability of the drug.

GCS reduce the biological effect of the drug Lykopid.

special instructions

At the beginning of taking the drug Likopid 10 mg, an exacerbation of the symptoms of chronic and latent diseases is possible, associated with the main pharmacological effects of the drug.

In elderly people, Likopid 10 mg is used with caution, strictly under the supervision of a physician. Elderly patients are recommended to start treatment with half doses (1/2 of the therapeutic dose), in the absence of side effects, increasing the dose of the drug to the required therapeutic dose.

The decision to prescribe Licopid tablets 10 mg to patients with a combination of diagnoses of psoriasis and gout should be made by a doctor when assessing the risk/benefit ratio, due to the potential risk of exacerbation of gouty arthritis and joint swelling. If the doctor decides to prescribe the drug Likopid tablets 10 mg in a situation where the patient has a combination of diagnoses of psoriasis and gout, treatment should begin with low doses, in the absence of side effects, increasing the dose to a therapeutic one.

Each Likopid 10 mg tablet contains sucrose in the amount of 0.001 XE (bread units), which should be taken into account in patients with diabetes.

Each Lykopid 10 mg tablet contains 0.184 grams of lactose, which should be taken into account by patients suffering from hypolactasia (lactose intolerance, in which the body experiences a decrease in the level of lactase, the enzyme necessary to digest lactose).

Impact on the ability to drive vehicles and operate machinery

Does not affect the ability to drive vehicles and complex machinery.

Pregnancy and lactation

Taking Likopid 10 mg is contraindicated for women during pregnancy and breastfeeding.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

The drug should be stored in a dry place, protected from light, out of reach of children, at a temperature not exceeding 25°C. Shelf life - 5 years. Do not use after expiration date.