Trimecaine release form. Instructions for use of trimecaine, indications and side effects, analogues. Interactions with other active ingredients

2 ml - ampoules (10) - cardboard packs.

pharmachologic effect

Local anesthetic. Causes fast-onset long-term conduction, infiltration, epidural, spinal anesthesia. The mechanism of action is due to the stabilization of neuronal membranes and the prevention of the occurrence and conduction of a nerve impulse. It has a more intense and long-lasting effect than procaine. Low toxicity, does not cause local tissue irritation.

It has an antiarrhythmic effect and belongs to class IB. Experimental studies have shown that its antiarrhythmic effect is 1.5 times stronger than that of. However, for ventricular extrasystole in patients with acute myocardial infarction, it is less effective than lidocaine.

Pharmacokinetics

With intravenous administration, T1/2 in the α-phase is about 8.3 minutes, in the β-phase - about 168 minutes.

Indications

Conduction, infiltration, epidural and spinal anesthesia.

Ventricular arrhythmias in acute cases, ventricular arrhythmias (independent of the concentration of potassium in the blood) during intoxication with digitalis drugs, ventricular tachycardia, arrhythmias during surgical interventions and cardiac catheterization.

Contraindications

Hypersensitivity to trimecaine.

Dosage

Individual, depending on the type of anesthesia and indications.

Side effects

From the side of the central nervous system: headache, dizziness.

Allergic reactions: urticaria, anaphylactic shock.

Others: pale skin, nausea.

Drug interactions

Which is often used in combination with trimecaine, causes local vasoconstriction, which leads to a slowdown in the absorption of trimecaine, providing an increase and prolongation of its anesthetic effect, reducing the systemic effect.

Name: Trimecain (Trimecainum)

Pharmacological effects:
Local anesthetic; the effect is stronger and longer lasting than novocaine.

Trimecaine - indications for use:

Conduction (pain relief by applying an anesthetic substance to the area of ​​the nerve trunk innervating the surgical field or painful area) or infiltration (pain relief by soaking the tissue of the surgical field with a local anesthetic solution) anesthesia.

Trimecaine - method of application:

For infiltration anesthesia, up to 800 ml of a 0.25% solution is administered; up to 400 ml of a 0.5% solution or up to 100 ml of a 1% solution; for conduction anesthesia - up to 100 ml of 1% or up to 20 ml of 2% solution.

Trimecaine - side effects:

Facial paleness, headache, nausea.

Trimecaine - contraindications:

Increased individual sensitivity to the drug. Severe liver and kidney diseases.

Trimecain - release form:

Powder.

Trimekain - storage conditions:

List B. In normally sealed glass jars.

Trimecaine - synonyms:

Mesocaine, Trimecaine hydrochloride, Mesdicaine, Mezidicaine.

Trimecaine - additionally:

Trimecaine is also included in the preparations dioxykol, Levosin ointment, and tsimizol.

Important!
Before using the medicine Trimekain you should consult your doctor. This instruction is intended for informational purposes only.

Local anesthetic. Causes fast-onset long-term conduction, infiltration, epidural, spinal anesthesia. The mechanism of action is due to the stabilization of neuronal membranes and the prevention of the occurrence and conduction of a nerve impulse. It has a more intense and long-lasting effect than procaine. Low toxicity, does not cause local tissue irritation.
It has an antiarrhythmic effect and belongs to class IB. Experimental studies have shown that its antiarrhythmic effect is 1.5 times stronger than that of lidocaine. However, for ventricular extrasystole in patients with acute myocardial infarction, it is less effective than lidocaine.

Pharmacokinetics

With intravenous administration, T1/2 in the α-phase is about 8.3 minutes, in the β-phase - about 168 minutes.

Indications for use

Conduction, infiltration, epidural and spinal anesthesia.
Ventricular arrhythmias in acute myocardial infarction, ventricular arrhythmias (independent of the concentration of potassium in the blood) during intoxication with digitalis drugs, ventricular tachycardia, arrhythmias during surgical interventions and cardiac catheterization.

Dosage regimen

Individual, depending on the type of anesthesia and indications.

Side effect

From the side of the central nervous system: headache, dizziness.
Allergic reactions: urticaria, anaphylactic shock.
Others: pale skin, nausea.

Contraindications for use

Hypersensitivity to trimecaine.

Use during pregnancy and breastfeeding

The safety of trimecaine during pregnancy and lactation (breastfeeding) has not been established.

Use for liver dysfunction

special instructions

Trimecaine (like other local anesthetics) in combination with vasoconstrictors is not used in patients with arterial hypertension, peripheral vascular diseases, or for anesthesia of tissues supplied by terminal arteries (terminal phalanges, penis).
Trimecaine is not recommended for use in patients with liver metabolic disorders or heart failure.

Drug interactions

Norepinephrine, which is often used in combination with trimecaine, causes local vasoconstriction, which leads to a slowdown in the absorption of trimecaine, providing an increase and prolongation of its anesthetic effect, reducing the systemic effect.

Local anesthetic. Causes fast-onset long-term conduction, infiltration, epidural, spinal anesthesia. The mechanism of action is due to the stabilization of neuronal membranes and the prevention of the occurrence and conduction of a nerve impulse. It has a more intense and long-lasting effect than procaine (novocaine). Low toxicity, does not cause local tissue irritation. It has an antiarrhythmic effect and belongs to class IB.

Experimental studies have shown that its antiarrhythmic effect is 1.5 times stronger than that of lidocaine. However, for ventricular extrasystole in patients with acute myocardial infarction, it is less effective than lidocaine.

Pharmacokinetics

With intravenous administration, T1/2 in the α-phase is about 8.3 minutes, in the β-phase - about 168 minutes.

Indications

Local anesthesia - superficial, infiltration, conduction and spinal; ventricular arrhythmias during acute myocardial infarction, ventricular arrhythmias (independent of the concentration of potassium in the blood) during intoxication with digitalis drugs, ventricular tachycardia, arrhythmias during surgical interventions and cardiac catheterization.

Contraindications

Hypersensitivity, sinus node weakness, AV block, severe bradycardia, cardiogenic shock, liver pathology.

Directions for use and doses

For superficial anesthesia, a 2-5% solution is used, for infiltration - 0.125-0.25-0.5% solution in an amount of up to 1500-800-400 ml, respectively;

• with conduction - 1-2% solution in an amount of 100-20 ml;
• spinal - 5% solution in an amount of 2-3 ml.

To stop rhythm disturbances, 80-120 mg is administered in the form of a 2% solution at a rate of 2 mg/min.

Side effect

Hypotension, headache, dizziness, drowsiness, anxiety, tinnitus, numbness of the tongue and oral mucosa, blurred vision, convulsive twitching, tremor, bradycardia.

Special instructions and precautions

Trimecaine (like other local anesthetics) in combination with vasoconstrictors is not used in patients with arterial hypertension, peripheral vascular diseases, or for anesthesia of tissues supplied by terminal arteries (terminal phalanges, penis).

Use during pregnancy and breastfeeding

The safety of trimecaine during pregnancy and lactation (breastfeeding) has not been established.

Interaction with other drugs

Norepinephrine, which is often used in combination with trimecaine, causes local vasoconstriction, which leads to a slowdown in the absorption of trimecaine, providing an increase and prolongation of its anesthetic effect, reducing the systemic effect.

Trimecaine is used as a local anesthetic drug for infiltration and conduction anesthesia in dentistry.

Dental patients have a persistent psycho-emotional attitude towards pain when thinking about dental treatment. When choosing an anesthetic, the following factors are taken into account:

• Determine the patient's risk group
• Presence of hereditary, chronic diseases
• Age category

Available in the form of a white powder with a yellowish tint and a 2% solution in 2 ml ampoules. It is highly resistant to acidic environments.

Good lipophilicity facilitates the penetration of the anesthetic through the sheath of nerve fibers. By binding to receptors, it slows down the depolarization process, and the threshold of myocardial excitability increases. The resting potential lengthens.

The refractory (short-term) period of disappearance of the excitability of nerve and muscle tissues, after their response to the stimulus, is prolonged. Relieves digitalis toxic arrhythmia. Has a depressing effect on the cerebral cortex.

Antiarrhythmic properties are 1.5 times higher than those of lidocaine. Efficiency decreases if the patient has ventricular extrasystole during acute myocardial infarction.

The anesthetic activity of trimecaine is higher and occurs faster than that of novocaine. The half-life is 1.5 hours. It has a vasodilating effect and is used simultaneously with vasoconstrictors (vasoconstrictor drugs).

It has a mild anticonvulsant, hypnotic and sedative effect.

Purpose and dosage of the drug

Trimecaine is indicated for the following dental procedures:

• Carrying out some types of tooth-preserving operations
• Prosthetics
• Implantation
• Direct and indirect dental restoration

Infiltration anesthesia – р – р 0.125%, 0.25%, 0.5%. Quantity – 1500-400 ml

Conductive – r – r 1-2% 20-100 ml

Adrenaline solution 0.1% is mainly used as a vasoconstrictor.

Precautionary measures

Trimecaine is not prescribed if the patient has peripheral vascular damage or arterial hypertension.

Use of anesthetic in childhood:

4-8 ml 1% r – r, 2-4 ml 2% r – r (2-5) years

10-20 ml 1% and 5-10 ml 2% r – r (6-11) years

Contraindications for use

• Damage to the circulatory system - atherosclerosis
• Heart disease – failure, atrioventricular block
• Individual intolerance
• Kidney and liver diseases
• Pregnancy

Due to the increasing incidence of local reactions, this anesthetic is being replaced with more effective drugs.