The drug thiamine chloride indications for use. Medicinal reference book geotar. The ability to influence the reaction rate when driving vehicles or other mechanisms

Thiamine chloride– vitamin B1 preparation.

Pharmacological properties

Thiamine plays an important role in the life of the body, is part of a number of enzymes and is involved in carbohydrate metabolism, in the processes of decarboxylation of a-keto acids and the synthesis of acetyl CoA. It influences the conduction of nerve excitation in synapses, has ganglion-blocking and curare-like properties. It is of great importance for the function of the nervous system, digestive system, cardiac activity, and the endocrine system. The source of thiamine for humans is food. In the absence or insufficient intake of it from food or in various conditions that prevent its absorption and assimilation, a person develops hypo- and vitamin B1 deficiency. The initial stages of vitamin B1 deficiency are characterized by nervous disorders (neurasthenia, headaches, migraines, fatigue, insomnia, pain and sensory disturbances in the extremities, muscle weakness, cramps in the calves), disorders of the cardiovascular system (shortness of breath, enlargement of the heart, rhythm disturbance) and digestive organs (anorexia, intestinal atony, constipation). Vitamin B1 deficiency, called beriberi, occurs either with paralysis and exhaustion, or with heart damage and edema. Thiamine taken orally is absorbed in the small intestine, partially being inactivated by thiaminase.

Pharmacokinetics. Thiamine chloride, when administered intramuscularly, is quickly and completely absorbed. It is distributed fairly evenly throughout all organs and tissues. Relatively higher Instructions for use: Thiamine chloride in the myocardium, skeletal muscles, nervous tissue and liver is associated with increased consumption of thiamine by these structures. The drug is metabolized in the liver and excreted by the kidneys, about 8 - 10% - unchanged.

Indications for use of Thiamine chloride

Hypovitaminosis and vitamin B1 deficiency, incl. in patients on tube feeding, hemodialysis, and with malabsorption syndrome. As part of complex therapy - neuritis and polyneuritis, radiculitis, neuralgia, peripheral paresis and paralysis, Wernicke's encephalopathy, Korsakoff's psychosis, chronic liver damage, various intoxications, myocardial dystrophy, coronary circulatory disorders, gastric and duodenal ulcers, atonic constipation, atony intestines; thyrotoxicosis, endarteritis; dermatoses (eczema, atopic dermatitis, psoriasis, lichen planus) with neurotrophic changes and metabolic disorders; pyoderma.

Directions for use and doses

Intramuscularly (deep into the muscle). It is recommended to start parenteral administration with small doses (no more than 0.5 ml of a 5 or 2.5% solution) and only if well tolerated, higher doses are administered. Adults are prescribed 0.02 - 0.05 g of thiamine chloride (1 ml of 2.5 or 5% solution) 1 time per day, daily; children are administered 0.0125 g (0.5 ml of 2.5% solution) of thiamine chloride. The course of treatment is 10 - 30 injections.

Features of application

Parenteral administration is recommended only if oral administration is not possible (nausea, vomiting, malabsorption syndrome, preoperative or postoperative conditions). In Wernicke encephalopathy, dextrose should be given before thiamine.

Side effects

Allergic reactions (urticaria, itching, angioedema, rarely - anaphylactic shock), sweating, tachycardia. Rarely pain (due to low pH of solutions).

Interaction with other drugs

Thiamine chloride solution should not be mixed with solutions containing sulfites, because in them it completely disintegrates. Simultaneous parenteral administration of thiamine with pyridoxine or cyanocobalamin is not recommended: pyridoxine makes it difficult to convert thiamine into a biologically active form, cyanocobalamin increases the allergenic effect of thiamine. Do not mix thiamine and penicillin or streptomycin (destruction of antibiotics), thiamine and niacin (destruction of thiamine) in the same syringe. Weakens the effect of depolarizing muscle relaxants (suxamethonium iodide, etc.).

Contraindications

Hypersensitivity.

Overdose

No cases of thiamine chloride overdose have been reported.

Instructions for medical use

medicine

Thiamine hydrochloride

Tradename

Thiamine hydrochloride

International nonproprietary name

Dosage form

Solution for injection 50 mg/ml

Compound

1 ml of solution (one ampoule) contains:

active substance - thiamine hydrochloride - 50 mg,

Excipients: Unithiol, water for injection.

Description

Transparent colorless or yellowish liquid with a weak characteristic odor.

Pharmacotherapeutic group

Vitamins. Vitamin B 1 and its combination with vitamins B 6 and B 12. Vitamin B 1. Thiamine.

ATX code A11DA01

Pharmacological properties

Pharmacokinetics

Thiamine hydrochloride, when administered intramuscularly, is quickly and completely absorbed. It is distributed fairly evenly throughout all organs and tissues. The relatively high content of thiamine hydrochloride in the myocardium, skeletal muscle, nervous tissue and liver is associated with increased thiamine consumption by these structures. Metabolized in the liver and excreted by the kidneys, about 8-10% unchanged.

Pharmacodynamics

In the body, thiamine hydrochloride is converted into an active form - thiamine pyrophosphate (cocarboxylase), which activates a number of enzymes involved in carbohydrate, protein and lipid metabolism. Participates in the processes of nerve excitation in synapses. It has weak ganglion-blocking and curare-like properties, affects the processes of nerve excitation in synapses, protects cell membranes from the toxic effects of peroxidation products.

Indications for use

Hypovitaminosis and vitamin B1 deficiency (including in patients on

tube feeding, hemodialysis, patients suffering from malabsorption syndrome)

As part of complex therapy

Dystrophic processes (starvation, myocardial dystrophy, atony

intestines, atonic constipation, severe liver dysfunction, diabetes mellitus)

Diseases of the peripheral nervous system (neuritis, radiculitis, polyneuritis, neuralgia, peripheral paresis or paralysis)

Skin diseases (dermatoses, lichen, psoriasis, eczema)

Intoxication (including chronic alcoholism - Wernicke-Korsakoff syndrome, thyrotoxicosis).

Directions for use and doses

For adults 25 - 50 mg of thiamine hydrochloride (0.5 - 1 ml of 5% solution) is administered deeply intramuscularly once a day every day. It is recommended to start parenteral administration of thiamine with small doses (no more than 0.5 ml of a 5% solution); if the drug is well tolerated, 1 ml is administered once a day. The course of treatment is usually 10-30 days.

For children over 8 years of age, 12.5 mg (0.25 ml of 5% solution) of thiamine hydrochloride is administered deeply intramuscularly once a day, daily.

Side effects

• pain and burning at the injection site
• nausea, anorexia, decreased intestinal tone, intestinal hemorrhages, difficulty swallowing
• headache, dizziness, anxiety, paresthesia
• optic nerve damage
• allergic reactions (urticaria, skin itching, angioedema)
• difficulty breathing, shortness of breath, bronchospastic syndrome, convulsions, anaphylactic shock
• tachycardia, arrhythmias, collapse
• dermatitis, rashes
• disturbance of liver enzyme activity
• general disorders: increased sweating, chills, tremor, general weakness, swelling, fever
• others: sympathoplegia - the ability of thiamine to form complexes with various mediators, which may be accompanied by a decrease in blood pressure, the occurrence of cardiac arrhythmias, impaired contraction of skeletal (including respiratory) muscles, and depression of the central nervous system.

Contraindications

Hypersensitivity to the components of the drug

Allergic diseases

Idiosyncrasy

Premenopausal and menopausal periods in women.

Carefully

Wernicke's encephalopathy.

Drug interactions

When thiamine hydrochloride is used together with other drugs, it is possible: with depolarizing muscle relaxants (suxamethonium chloride), choline derivatives- weakening of their therapeutic effect;

with thiosemicarbazone, 5-fluorouracil- inhibition of thiamine activity;

with caffeine, drugs containing sulfur and estrogens- increasing the body's need for thiamine;

with anticonvulsants (phenobarbital, phenytoin, carbamazepine), digoxin, indomethacin, antacids- development of thiamine deficiency;

with cyanocobalamin, pyridoxine- difficulty converting thiamine into a phosphorylated biologically active form and enhancing its allergenic effect. Simultaneous parenteral administration of thiamine with pyridoxine (vitamin B 6) or cyanocobalamin (vitamin B 12) is not recommended;

with ethanol- slowing down the rate of thiamine absorption;

with adrenomimetics, sympathomimetics- weakening of their therapeutic effect.

When administered intravenously simultaneously with solutions containing sodium hydrosulfite as an antioxidant or preservative, thiamine is unstable.

Thiamine hydrochloride should not be mixed in one syringe:

• with benzylpenicillin or streptomycin, as this will destroy the antibiotics;
• with nicotinic acid or solutions containing sulfites, as this will lead to the destruction of thiamine;
• with carbonates, citrates, barbiturates, with Cu 2+, iodides, iron ammonium citrate, tannic acid, since thiamine is unstable in alkaline and neutral solutions.

special instructions

Before parenteral use of thiamine hydrochloride solution, it is necessary to conduct a skin test to determine individual sensitivity to the drug. After the injection, monitoring is required for 30 minutes due to the possibility of severe allergic reactions.

Anaphylactic reactions develop more often after intravenous administration in high doses; special caution should be observed when administering thiamine intravenously due to the risk of developing sympathoplegia.

In Wernicke-Korsakoff encephalopathy, dextrose should be given before thiamine.

It is advisable to do thiamine injections no earlier than 12 hours after pyridoxine injection.

When administered intramuscularly, the drug should be injected deep into the muscle; when administered intravenously, it should be administered slowly.

The drug should not be used as a replacement for a balanced diet, only in combination with diet therapy.

Prescribed with caution for increased excitability of the nervous system, hyperacid forms of duodenal ulcer.

In patients with alcoholism, symptoms of side effects of the drug may increase.
The drug (when taken in high doses) can distort the results when determining theophylline in blood serum by the spectrophotometric method and urobilinogen using the Ehrlich reagent.

Children's age

For children over 8 years of age, a 2.5% solution of thiamine hydrochloride is usually used; for children, a 5% solution is allowed with caution.

Pregnancy, lactation

There have been no controlled studies of the safety of thiamine in pregnant women. Thiamine hydrochloride may be used when the expected benefit to the mother outweighs the potential risk to the fetus. Thiamine passes into breast milk; use during lactation is possible if the expected benefit to the mother outweighs the potential risk to the child.

Features of the effect of the drug on the ability to drive vehicles and especially dangerous mechanisms

Does not affect the ability to drive a car or operate machinery.

Overdose

Symptoms: nausea, vomiting, tachycardia, arterial hypotension, headache, irritability, weakness, fatigue, swelling, muscle tremors, cardiac arrhythmia, allergic reactions, sweating, shortness of breath.

Treatment: drug withdrawal, symptomatic therapy.

Release form and packaging

1 ml in glass ampoules.

The text is applied to each ampoule using intaglio printing with quick-fixing ink or a label made of paper for multicolor printing or offset paper, or a self-adhesive label is affixed.

10 ampoules, together with a knife for opening ampoules or an ampoule scarifier, are placed in a cardboard box with a corrugated liner made of corrugated paper.

The box is covered with a label-parcel made from paper for multicolor printing or offset paper.

The boxes, along with instructions for medical use in the state and Russian languages, are placed in group containers. The number of instructions for medical use in the state and Russian languages ​​must correspond to the number of packages.

Or 10 ampoules are placed in a blister pack made of polyvinyl chloride film. 1 blister pack of ampoules, along with a knife for opening ampoules or an ampoule scarifier and instructions for medical use in the state and Russian languages, is placed in a pack of chrome-ersatz cardboard.

When prescribing the vitamin thiamine chloride, many patients have a question: what kind of vitamin is thiamine chloride? In fact, this is the pharmaceutical name for vitamin B1 based on the active substance.

The main purpose of the drug is to replenish the lack of vitamin B1 in the body.

Thiamine is a water-soluble vitamin. This substance is involved in providing the body with carbohydrates, fats and proteins. With the participation of thiamine, the processes of conducting nervous excitation in synapses are carried out. The drug is excreted from the human body through the intestines, liver and kidneys.

Thiamine bromide is responsible for the formation of nerve excitation in synapses. It is necessary for the normal functioning of the digestive, nervous, cardiovascular and endocrine systems. It can be found in products of plant origin: nuts, liver, milk, egg yolks, carrots, yeast.

Thiamine bromide is available in various forms: tablets, dragees And ampoules for intramuscular and intravenous administration. For prophylactic purposes the drug can be prescribed to children from birth as prescribed by a doctor with the selection of the appropriate dosage. In case of intolerance to individual components of the medication, liquid or dry yeast from 50 to 100 grams per day may be prescribed as an alternative treatment.

Composition and release form

The drug is produced in ampoules in the form of a solution for intramuscular and intravenous administration. It appears as a clear, colorless or slightly colored liquid. The substance has a slight odor. Sold in ampoules of 1 or 2 ml, packed in a cardboard box of 10 pieces.

One 1 ml ampoule contains:

• Thiamine hydrochloride 50 mg.
• Excipients: water, unithiol, disodium edetate.

Indications for use

The drug is used for medical reasons as part of complex treatment:

Contraindications for use

Contraindications for use are:

• Lactation period.
• Pregnancy.
• Childhood. It is a contraindication for certain dosage forms.
• Intolerance to the components of the drug.

Thiamine hydrochloride: drug instructions

The medicine is produced in the form of capsules, tablets, powder and solution for injection. The substance can be purchased at the pharmacy in bags, bottles and ampoules of 1 ml, depending on the form of the medicine. The medicine is dispensed in the pharmacy strictly according to the prescription. You can buy it at the pharmacy under the trade names: “Thiamin chloride”, “Thiamin bromide”, “Thiamin hydrochloride”.

The solution is intended for intramuscular administration. To check the tolerability of the drug, the first dose is no more than 0.5 ml.

If the body tolerates the administered substance well, then with subsequent injections the dosage can be increased.

The duration of treatment and dosage are determined by the doctor after clinical studies. The recommended course of treatment does not exceed 30 days with a dosage of no more than 1 ml of solution. The use of the substance may be accompanied by side effects. Common side effects include:

• Increased sweating.
• Tachycardia.
• The appearance of skin itching in the form of an allergic reaction.
• Quincke's edema.
• Hives.
• Development of anaphylactic shock. Most often occurs with high intravenous dosage.

There may also be pain at the injection site for a long time. If you follow your doctor's recommendations and Thiamine Chloride's instructions for using injections, cases of overdose do not occur.

Intramuscular administration of the drug is prescribed in cases that exclude other possible routes of taking the drug. If the patient experiences vomiting and nausea, and has also undergone surgery on internal organs, he is prescribed medication in the form of injections. In other cases, you can limit yourself to taking thiamine tablets.

A high dosage of the drug may adversely affect certain tests, which must be taken into account when prescribing treatment. In patients with Wernicke encephalopathy, the drug should be used after prior administration of dextrose.

Interaction with other dosage forms

Simultaneous intramuscular administration of thiamine with various substances can lead to:

• To the difficulty of the process of converting the vitamin into a biologically active form and to an increased risk of allergies when administered with vitamin B6.
• To the development of allergic reactions when administered simultaneously with vitamin B12.
• To reduce pharmacological activity when administered simultaneously with phentolamine, propranolol, and hypnotics.

It is prohibited to mix thiamine with benzylpenicillin, nicotinic acid, streptomycin and drugs containing sulfites in one syringe.

Thiamine chloride-Darnitsa (Vitamin B1-Darnitsa)

International nonproprietary name

Dosage form

Solution for injection 5%

Compound

1 ml of solution contains

active substance - thiamine hydrochloride 50 mg

Excipients: unithiol, water for injection

Description

Transparent, colorless or slightly yellowish liquid with a weak characteristic odor.

Pharmacotherapeutic group

Vitamins. Vitamin B1.

ATX code A11DA01

Pharmacological properties

Pharmacokinetics.

The drug is well absorbed. Phosphorylation takes place in the liver. Accumulates in the liver, heart, brain, kidneys, spleen. It is excreted by the liver and kidneys, about 8-10% is unchanged.

Pharmacodynamics

Thiamine chloride-Darnitsa - a synthetic preparation of vitamin B1 belongs to water-soluble vitamins. In the human body, as a result of phosphorylation processes, it is converted into cocarboxylase, which is a coenzyme of many enzymatic reactions. Vitamin B1 plays an important role in metabolism and neuro-reflex regulation, influences the conduction of nerve excitation at synapses, and has a ganglion-blocking and curare-like effect. The drug may weaken the curare-like effect of depolarizing muscle relaxants.

Indications for use

- hypovitaminosis and vitamin B1 deficiency

Treatment of burns, prolonged fever as part of complex therapy

Neuritis, polyneuritis, radiculitis, neuralgia, peripheral paralysis, encephalopathy, neurasthenia

Peptic ulcer of the stomach and duodenum, intestinal atony, chronic liver damage

Myocardial dystrophy, endarteritis

Dermatoses of neurogenic origin, pyoderma, eczema, psoriasis

Directions for use and doses

For adults.

The drug is prescribed intramuscularly (deep into the muscle) at a dose of 25-50 mg (0.5-1 ml) once a day, daily. Administration begins with small doses - no more than 25 mg (0.5 ml of a 5% solution) and only if well tolerated, higher doses are administered - 50 mg (1 ml of a 5% solution). The course of treatment is 10-30 injections.

Wernicke-Korsakoff encephalopathy: the drug is prescribed intramuscularly (deep into the muscle) at a dose of 50-100 mg (1-2 ml of 5% solution) 2 times a day until clinical improvement. The likelihood of developing an allergic reaction to the administration of vitamin B1 should be taken into account.

Children over 8 years old.

The drug is prescribed in a dose of 12.5 mg (0.25 ml of 5% solution) once a day, daily. The course of treatment is 10-30 injections.

Side effects

Tachycardia, palpitations, collapse

Headache, dizziness, anxiety, paresthesia

Optic nerve damage

Difficulty breathing, shortness of breath

Difficulty swallowing, nausea, intestinal hemorrhages

Hyperemia, itching

Dermatitis, rashes, urticaria, Quincke's edema, bronchospastic syndrome with convulsions, anaphylactic shock

Impaired liver enzyme activity

- general disorders: increased sweating, chills, tremor, general weakness, swelling, fever

Reactions at the injection site: rash, itching

Others: the phenomenon of synaptoplegia - the ability of thiamine to form complexes with various mediators can be accompanied by a decrease in blood pressure, the occurrence of cardiac arrhythmias, impaired contraction of skeletal (including respiratory) muscles, depression of the central nervous system; Thiamine chloride promotes the formation of staphylococcus resistance to antibiotics.

Contraindications

Hypersensitivity to the components of the drug

Allergic diseases

Idiosyncrasy

Premenopausal and menopausal periods in women

Children's age up to 8 years.

Drug interactions

When using the drug together with other drugs, it is possible: with depolarizing muscle relaxants (suxamethonium chloride), choline derivatives- weakening of their therapeutic effect;

with thiosemicarbazone, 5-fluorouracil- inhibition of thiamine activity;

with caffeine, drugs containing sulfur and estrogens- increasing the body's need for thiamine;

with anticonvulsants (phenobarbital, phenytoin, carbamazepine), digoxin, indomethacin, antacids- development of thiamine deficiency;

with cyanocobalamin, pyridoxine- difficulty converting thiamine into a phosphorylated biologically active form and enhancing its allergenic effect. Simultaneous parenteral administration of thiamine with pyridoxine (vitamin B6) or cyanocobalamin (vitamin B12) is not recommended;

with ethanol- slowing down the rate of thiamine absorption.

with adrenomimetics, sympathomimetics- weakening of their therapeutic effect.

When administered intravenously simultaneously with solutions containing sodium hydrosulfite as an antioxidant or preservative, thiamine is unstable.

Thiamine chloride should not be mixed in one syringe:

with benzylpenicillin or streptomycin, as this will destroy the antibiotics;

with nicotinic acid or solutions containing sulfites, as this will lead to the destruction of thiamine;

with carbonates, citrates, barbiturates, with Cu2+, iodides, iron ammonium citrate, tannic acid, since thiamine is unstable in alkaline and neutral solutions.

special instructions

Before parenteral use of thiamine chloride solution, it is necessary to conduct a skin test to determine individual sensitivity to the drug. After the injection, monitoring is required for 30 minutes due to the possibility of severe allergic reactions.

Anaphylactic reactions develop more often after intravenous administration in high doses.

It is advisable to do thiamine injections no earlier than 12 hours after pyridoxine injection.

When administered intramuscularly, the drug should be injected deep into the muscle, when administered intravenously - slowly.

Intramuscular and subcutaneous injections are painful due to the low pH of the solution.

Daily requirement for vitamin B1: for adult men - 1.2-2.1 mg, for elderly people - 1.2-1.4 mg, for women - 1.1-1.5 mg with the addition of 0.4 mg for pregnant women and 0.6 mg for women during breastfeeding, for children, depending on age, 0.3-0.5 mg.

The drug should not be used as a replacement for a balanced diet, only in combination with diet therapy.

The injection form of the drug should be used in the treatment of patients with impaired absorption in the intestine or with gastrectomy, if it is impossible to take thiamine in tablet form (nausea, vomiting, pre- and postoperative period), as well as in severe forms of the disease or at the beginning of treatment for faster achieving a therapeutic effect.

Prescribed with caution for increased excitability of the nervous system, hyperacid forms of duodenal ulcer.

For Wernicke encephalopathy, thiamine must be taken before administering glucose.

If an allergy to vitamin B1 is detected, the patient should avoid rice, buckwheat, meat, and bread (kinds baked from wholemeal flour).

In patients with alcoholism, symptoms of side effects of the drug may increase.

Thiamine can weaken the effect of depolarizing muscle relaxants, adrenolytic and sympathomimetic drugs.

The drug (when taken in high doses) can distort the results when determining theophylline in blood serum by the spectrophotometric method and urobilinogen using the Ehrlich reagent.

Pregnancy, lactation

It is possible to use the drug during pregnancy or breastfeeding according to indications in recommended doses.

Children

For children, a 2.5% solution of thiamine chloride is usually used. It is allowed to administer a 5% solution to children over 8 years of age.

Features of the effect of the drug on the ability to drive vehicles and especially dangerous mechanisms

During treatment, care should be taken when driving vehicles and working with complex mechanisms due to the possibility of developing side effects from the nervous system.

Overdose

Symptoms: it is possible to increase the symptoms of side effects of the drug - hypercoagulation, disturbance of purine metabolism.

Treatment: drug withdrawal, symptomatic therapy.

Release form and packaging

1 ml of the drug in glass ampoules.

A label made of paper with a self-adhesive coating is glued onto the ampoule or applied with intaglio printing ink for glass products.

5 ampoules together with a knife for opening the ampoules are placed in a blister pack (cassette).

Two blister packs together with instructions for medical use in the state and Russian languages ​​are placed in a pack.

10 ampoules, along with instructions for medical use in the state and Russian languages ​​and a knife for opening ampoules, are placed in a box with a corrugated liner.

When packaging ampoules with a colored break ring, or a colored break point, the placement of knives for opening the ampoules is excluded.

Storage conditions

Store in original packaging at a temperature not exceeding 25 °C. Do not freeze.

Keep out of the reach of children!

Shelf life

Do not use after expiration date

Conditions for dispensing from pharmacies

On prescription

Manufacturer

PJSC "Pharmaceutical Firm "Darnitsa"

Ukraine, 02093, Kyiv, st. Boryspilskaya, 13

Registration Certificate Holder

PJSC "Pharmaceutical Firm "Darnitsa", Ukraine

Address of the organization receiving claims from consumers regarding product quality in the territory of the Republic of Kazakhstan:

phone: (+ 727) 2424328

Address of the organization responsible for post-registration monitoring of the safety of the medicinal product:

050043, Almaty, st. Navoi 68, apt. 49

phone: (+ 727) 2424328

e-mail: [email protected]

Dosage form:  solution for intramuscular administration Compound:

1 ml of solution contains:

active substance: thiamine hydrochloride - 50 mg;

excipients: sodium dimercaptopropanesulfonate monohydrate (unithiol) - 2 mg, disodium edetate - 0.2 mg, water for injection.

Description:

Colorless or slightly colored transparent liquid with a weak characteristic odor.

Pharmacotherapeutic group: vitamin ATX:  

A.11.D.A.01 Thiamine

Pharmacodynamics:

Vitamin B1 (thiamine) is a water-soluble vitamin. In the body, as a result of phosphorylation processes, it is converted into cocarboxylase, which is a coenzyme of many enzymatic reactions.

Plays an important role in carbohydrate, protein and fat metabolism, as well as in the processes of nerve excitation in synapses.

Pharmacokinetics:

The concentration in the blood is relatively low, while predominantly free thiamine circulates in the plasma, and its phosphorus esters circulate in erythrocytes and leukocytes. Phosphorylation occurs in the liver. The most active phosphorus ester is thiamine diphosphate, which has coenzyme activity. It accumulates mainly in the liver, heart, brain, kidneys, and spleen. 1/2 of the total amount is contained in striated muscles and myocardium and about 40% in internal organs. Excreted through the intestines and kidneys.

Indications:

Hypovitaminosis and vitamin B1 deficiency.

As part of complex therapy:

Neuritis, radiculitis, neuralgia; peripheral paresis and paralysis;

Peptic ulcer of the stomach and duodenum; anorexia, intestinal atony, atonic constipation;

Myocardial dystrophy; violation of coronary circulation;

Dermatoses (eczema, neurodermatitis, psoriasis, lichen planus) with neurotrophic changes and metabolic disorders.

Contraindications:

Increased individual sensitivity, pregnancy, lactation, childhood.

Carefully:Wernicke encephalopathy, premenopausal and menopausal women. Directions for use and dosage:

The thiamine solution is injected intramuscularly (deep into the muscle).

Side effects:

Allergic reactions are possible (urticaria, skin itching, Quincke's edema, anaphylactic shock), increased sweating, tachycardia.

Sometimes there is pain (due to the low pH of the solution) at the injection site.

Interaction:

Simultaneous parenteral administration of thiamine and pyridoxine (vitamin B6) or cyanocobalamin (vitamin Bi2) is not recommended. B12 enhances the allergenic effect of thiamine. WB makes it difficult to convert thiamine into its biologically active form. You should not mix vitamin Bi and benzylpenicillin or streptomycin (destruction of antibiotics), vitamin Bi and nicotinic acid (destruction of vitamin Bi) in the same syringe. Thiamine reduces the pharmacological activity of suxamethonium iodide, phentolamine, propranolol, sympatholytics (reserpine), hypnotics (hypnotic and hypotensive effects are reduced).

Thiamine solution should not be mixed with solutions containing sulfites, because in them it completely disintegrates.

Thiamine is unstable in alkaline and neutral solutions; administration with carbonates, citrates, barbiturates, and copper preparations is not recommended.

Special instructions:

When determining theophylline in blood serum by the spectrophotometric method, urobilinogen using the Ehrlich reagent can distort the results (when taking high doses). More often, an anaphylactic reaction develops after intravenous administration of large doses.

In Wernicke encephalopathy, dextrose should be given before thiamine.

Release form/dosage:

Solution for intramuscular administration 50 mg/ml.

Package:

Solution for intramuscular administration 50 mg/ml. 1 ml in neutral glass ampoules. 5 ampoules per PVC blister pack. 1 or 2 contour blister packs together with an ampoule knife or a ceramic ampoule scarifier and instructions for use are placed in a pack. 10 ampoules per cardboard box along with an ampoule knife or ceramic ampoule scarifier and instructions for use. When packaging an ampoule with notches, an ampoule knife or scarifier is not inserted.

Storage conditions:

In a place protected from light at a temperature of 0 to 25 ° C.

Keep out of the reach of children.

Best before date: 3 years. Do not use after expiration date. Conditions for dispensing from pharmacies: On prescription Registration number: P N001066/01 Registration date: 12.12.2008 Owner of the Registration Certificate:MOSKHIMPHARMPREPARATY im. N.A. Semashko, JSC