Glucose solution 20. Geotar medicinal reference book. Registration Certificate Holder

Instructions for use of Glucose 5% and 40% solution for injection
for dehydration and intoxication of the animal body
(developer organization: CJSC NPP "Agropharm", Voronezh)

I. General information
Trade name of the drug: Glucose 5% and 40% solution for injection (Glucosi 5%, 40% Solutio proinjectionibus).
International nonproprietary name: dextrose.

Dosage form: solution for injection.
Glucose 5% and 40% solution for injection as an active ingredient contains, respectively, 5 g or 40 g of crystalline hydrated glucose, as well as excipients: 0.026 g of sodium chloride, hydrochloric acid - up to pH 3-4, water for injection - up to 100 ml . In appearance, the drug is a colorless or slightly yellowish transparent liquid.

Glucose solutions of 5% and 40% are produced packaged in 100 ml glass bottles made of neutral glass, sealed with rubber stoppers reinforced with aluminum caps.
The shelf life of the medicinal product, subject to storage conditions, is 2 years from the date of production. After opening the bottle, unused medicinal product cannot be stored.
It is prohibited to use the medicinal product after the expiration date.
Glucose 5% and 40% solution for injection is stored in the manufacturer's sealed packaging in a dry place, protected from light, separately from food and feed, at a temperature of 0°C to 25°C. Solutions should be stored out of the reach of children.
Unused medicinal product is disposed of in accordance with legal requirements.

II. Pharmacological properties
Glucose 5% and 40% injection solution refers to carbohydrate nutrition preparations and tissue repair stimulators.
Glucose is involved in various metabolic processes in the body, enhances redox processes in the body, and improves the antitoxic function of the liver. Entering the tissues, it is phosphorylated, turning into glucose-6-phosphate, which is actively involved in many parts of the body’s metabolism.
Isotonic, 5%, glucose solution has a detoxifying, metabolic effect, and is a source of valuable, easily digestible nutrients. When glucose is metabolized in tissues, a significant amount of energy is released, which is necessary for the functioning of the body.
Hypertonic, 40%, glucose solution increases osmotic blood pressure, improves metabolic processes, antitoxic liver function and heart function, dilates blood vessels, enhances diuresis. Glucose stimulates the synthesis of hormones and enzymes, increases the defenses of the animal's body.
After administration, the drug is quickly absorbed from the injection site and distributed in the organs and tissues of the animal.

Glucose 5% and 40% in terms of the degree of impact on the body is classified as low-hazard substances according to GOST 12.1.007 (hazard class 4).

III. Application procedure
Glucose 5% and 40% is used in animals with large losses of body fluid (bleeding, toxic dyspepsia), shock, intoxication, metritis, vaginitis, as well as for dissolving various medications.

Contraindications to the use of the drug are the animal’s increased individual sensitivity to dextrose and diabetes mellitus.

Glucose 5% is used subcutaneously or intravenously. Glucose 40% - only intravenously.

Depending on the severity of the disease, the drug is administered to animals 1-2 times a day in the following doses:

When administered subcutaneously, the dose of the drug is administered fractionally to different parts of the body.
Doses and timing of use depend on the weight of the animal and the course of the disease.

No overdose symptoms have been identified in animals.
The specific effects of the drug upon its first use and withdrawal have not been established.

Avoid skipping the next dose of the drug, as this may lead to a decrease in its therapeutic effectiveness. If one dose is missed, the use of the drug is resumed as soon as possible in the same dosage and according to the same regimen.

When using Glucose 5% and 40% in accordance with these instructions, no side effects or complications are observed in animals.
The use of glucose solution does not exclude the use of other medications.
Livestock products are used without restrictions during and after use of the drug.

IV. Personal prevention measures
When carrying out therapeutic and preventive measures using Glucose, you should follow the general rules of personal hygiene and safety precautions provided for when working with medicines. While working with the drug, do not drink, smoke or eat. After finishing work, wash your hands with warm water and soap.
People with hypersensitivity to the components of the drug should avoid direct contact with the solution. If the drug accidentally comes into contact with the skin or mucous membranes, they must be washed with running water and soap. If allergic reactions occur or if the drug accidentally enters the human body, you should immediately contact a medical facility (bring with you the instructions for use of the drug or the label).

Empty drug bottles must not be used for household purposes; they must be disposed of with household waste.

Manufacturer: CJSC NPP "Agropharm", Russia, 394087, Voronezh region, Voronezh, st. Lomonosova, 114-b.

With the approval of this instruction, the instructions for the use of Glucose 5% and 40% solution for injection, approved by Rosselkhoznadzor on May 22, 2008, become invalid.

Dosage form

white tablets

Compound

Active ingredients: glucose-0.5 g; excipients: talc, stearic acid.

Pharmacodynamics

Due to its participation in various metabolic processes, glucose has a diverse effect on the body: it enhances redox processes, improves the antitoxic function of the liver, entering the tissues, phosphorylated, turning into glucose-6-phosphate, which is actively involved in many parts of the body’s metabolism, is source of valuable, easily digestible nutrients. When glucose is metabolized in tissues, a significant amount of energy is released, which is necessary for the functioning of the body.

Side effects

Hypervolemia, acute left ventricular failure. Overdose. Hyperglycemia. Treatment is symptomatic.

Selling Features

Available without a prescription

Indications

Hypoglycemia, carbohydrate deficiency

Contraindications

Diabetes mellitus (except in cases of hypoglycemia).

Drug interactions

Precautions for use

Prices for Glucose in other cities

Buy Glucose,Glucose in St. Petersburg,Glucose in Novosibirsk,Glucose in Yekaterinburg,Glucose in Nizhny Novgorod,Glucose in Kazan,Glucose in Chelyabinsk, Dosage form:  solution for infusion Compound:

For 1 ml:

Active component:
Dextrose (glucose) monohydratein terms of dextrose	0.05; 0.1; 0.2; 0.4 g
Excipients:
Sodium chloride	0.00026 g
0.1 M hydrochloric acid solution	Up to pH 3.0-4.1
Water for injections	Up to 1 ml
Theoretical osmolarity	277; 555; 1110; 2220 mOsm/l

Description: 5% and 10% solutions: transparent, colorless liquid.

20% and 40% solutions: transparent, colorless to light yellow liquid.

Pharmacotherapeutic group:Nutrition carbohydrate remedy ATX:  

Carbohydrates

Pharmacodynamics:

Glucose enhances redox processes in the body, improves the antitoxic function of the liver, enhances the contractile activity of the myocardium, and is a source of easily digestible carbohydrates.

The pharmacodynamic properties of 5%, 10%, 20% and 40% dextrose solutions are similar to the properties of glucose, the main source of energy for cellular metabolism.

5% dextrose solution is an isotopic solution with an osmolarity of about 277 mOsm/L. The caloric intake of a 5% dextrose solution is 200 kcal/l.

10% dextrose solution is a hypertonic solution with an osmolarity of about 555 mOsm/L. The caloric intake of a 10% dextrose solution is 400 kcal/l.

20% dextrose solution is a hypertonic solution with an osmolarity of about 1110 mOsm/L. The caloric intake of a 20% dextrose solution is 680 kcal/l.

40% dextrose solution is a hypertonic solution with an osmolarity of about 2220 mOsm/L. The caloric intake of a 40% dextrose solution is 1360 kcal/l.

As part of parenteral nutrition, 5%, 10%, 20%, and 40% dextrose solutions are administered as a source of carbohydrate (alone or as part of parenteral nutrition as needed).

5% and 10% dextrose solutions allow you to replenish fluid deficiency without simultaneous administration of ions.

20% dextrose solution Provides maximum calories in a minimum volume of liquid.

40% dextrose solution allows you to restore the concentration of glucose in the blood during hypoglycemia with the introduction of a minimal amount of fluid, increases the osmotic pressure of the blood, and increases diuresis.

Dextrose, entering tissues, is phosphorylated, turning into glucose-6-phosphate, which is actively involved in many parts of the body's metabolism.

When using dextrose solutions to dilute and dissolve parenterally administered drugs, the pharmacodynamic properties of the solution will depend on the substance added.

Pharmacokinetics:

Glucose is metabolized in two different ways: anaerobic and aerobic.

Dextrose, breaking down into pyruvic or lactic acid (anaerobic glycolysis), is metabolized to carbon dioxide and water, releasing energy.

When using a dextrose solution to dilute and dissolve parenterally administered drugs, the pharmacokinetic properties of the solution will depend on the substance added.

Indications:

5% glucose solution:

For dilution and dissolution of parenterally administered drugs.

10% glucose solution:

As a source of carbohydrates (alone or as part of parenteral nutrition if necessary);

For rehydration in case of fluid loss, especially in patients with a high carbohydrate requirement;

For dilution and dissolution of parenterally administered drugs;

For the prevention and treatment of hypoglycemia.

20% and 40% glucose solutions:

As a source of carbohydrates (alone or as part of parenteral nutrition if necessary), especially when limiting fluid intake is necessary;

Hypoglycemia.

Contraindications:

Isotonic glucose solution 5%:

decompensated diabetes mellitus; other known forms of glucose intolerance (eg metabolic stress); hyperosmolar coma; hyperglycemia and hyperlactatemia; administration of the solution during the first 24 hours after head injury; hypersensitivity to the components of the drug; use in patients with a known intolerance to corn or corn products (when receiving dextrose from corn); contraindications to any drugs added to a glucose solution.

Hypertonic glucose solution 10%:

decompensated diabetes mellitus and diabetes insipidus; other known forms of glucose intolerance (eg metabolic stress); hyperosmolar coma; hyperglycemia, hyperlactatemia; hemodilution and extracellular hyperhydration or hypervolemia; severe renal failure (with oliguria or anuria); decompensated heart failure; generalized edema (including pulmonary and cerebral edema) and cirrhosis of the liver with ascites; administration of the solution during the first 24 hours after head injury; hypersensitivity to the components of the drug; use in patients with a known intolerance to corn or corn products (when receiving dextrose from corn); contraindications to any drugs added to a glucose solution.

Hypertonic glucose solutions 20% and 40% (optional):

intracranial hemorrhage and hemorrhage in the spinal cord, childhood (for solutions over 20%).

Carefully:

Diabetes mellitus, intracranial hypertension, hyponatremia, childhood.

Pregnancy and lactation:

Dextrose solution 5% during pregnancy it is usually used as a hydration agent and a vehicle for the use of other drugs (particularly oxytocin).

Dextrose solution 5% and 10% can be used safely during pregnancy and breastfeeding, provided that electrolyte and fluid balance are monitored and within physiological limits. If a woman in labor is given intravenous glucose, the concentration of glucose in her blood should not exceed 11 mmol/l.

Try not to interrupt feeding during the infusion.

Purpose 20% and 40% dextrose solutions during pregnancy and breastfeeding is possible only as prescribed and under the supervision of a doctor, if the intended benefit to the mother outweighs the potential risk to the fetus or infant.

If dextrose solution is added to a medicinal product, the properties of the medicinal product and its use during pregnancy and breastfeeding are considered separately.

Directions for use and dosage:

Intravenously (drip). The drug is usually administered into a peripheral or central vein.

The concentration and dose of the administered solution depend on the age, body weight and clinical condition of the patient.

The use of the drug should be carried out under regular medical supervision. Clinical and biological parameters should be carefully monitored, in particular blood glucose concentrations, as well as water and electrolyte balance.

In adults with normal metabolism, the daily dose of administered glucose should not exceed 4-6 g/kg, i.e. about 250-450 g (with a decrease in metabolic rate, the daily dose is reduced to 200-300 g), while the daily volume of administered fluid is 30-40 ml/kg.

For children for parenteral nutrition, along with fats and amino acids, 6 g of glucose/kg/day is administered on the first day, subsequently up to 15 g/kg/day.

Injection rate: in a normal metabolic state, the maximum rate of administration to adults is 0.25-0.5 g/kg/h (with a decrease in metabolic rate, the rate of administration is reduced to 0.125-0.25 g/kg/h). In children, the rate of glucose administration should not exceed 0.5 g/kg/h.

To ensure complete absorption of dextrose administered in large doses, short-acting insulin is simultaneously prescribed at the rate of 1 unit of insulin per 4-5 g of dextrose.

With total parenteral nutrition, the administration of glucose should always be accompanied by the introduction of a sufficient amount of amino acid solutions, an emulsion of lipids, electrolytes, vitamins and microelements.

For patients with diabetes glucose is administered under the control of its content in the blood and urine.

For adults: 500-3000 ml per day.

For children, including newborns:

With a body weight of 0-10 kg - 100 ml/kg per day;

With a body weight of 10-20 kg - 1000 ml + additional 50 ml for each kg of body weight over 10 kg per day;

With body weight over 20 kg - 1500 ml + additional 20 ml for each kg of body weight over 20 kg per day.

Rate and volume of infusion depend on the age, body weight, clinical condition and metabolism of the patient, as well as on concomitant therapy. In children, they should be determined by the attending physician who has experience in the use of intravenous drugs in this category of patients.

The threshold for glucose utilization in the body must not be exceeded in order to avoid hyperglycemia, so the maximum dose of dextrose varies from 5 mg/kg/min for adults and 10-18 mg/kg/min for newborns and children, depending on age and total body weight.

The recommended dose when used for dilution and dissolution of parenterally administered drugs is usually 50-250 ml per dose of the administered drug, but the required volume should be determined based on the instructions for use of the added drugs. In this case, the dose and rate of administration of the solution are determined by the properties and dosage regimen of the diluted drug.

10% glucose solution:

Indications for use	Initial daily dose	Infusion rate
As a source of carbohydrates (alone or as part of parenteral nutrition if necessary)	500-3000 ml per day (7-40 ml/kg per day)	5 mg/kg/min (3 ml/kg/h)	The duration of treatment depends onclinical condition of the patient
Prevention and treatment of hypoglycemia
Rehydration in case of fluid loss and dehydration in patients with high carbohydrate needs
For dilution and dissolution of parenterally administered drugs	50-250 ml per dose of administered drug		Depending on the drug being diluted

Children and teenagers: the rate and volume of infusion depend on the age, body weight, clinical condition and metabolism of the patient, as well as concomitant therapy. They should be determined by a physician experienced in the use of intravenous drugs in children.

Indication for	Initial	Initial infusion rate*
application	daily dose	Newborns and premature babies	Babiesand childrenearlyage (1-23 months)	Children (2-11 years)	Teenagers (from 12 to 16-18 years old)
As a source of carbohydrates (alone or as part of parenteral nutrition if necessary)	- with a weight of 0-10 kg 100 ml/kg/day With a weight from 10 to 20 kg - 1000 ml + additional 50 ml for each kg of body weight over 10 kg/day - with a body weight of more than 20 kg - 1500 ml + additional 20 ml for each kg of body weight over 20 kg/day	6-11 ml/kg/h (10-18 mg/kg/min)	5-11 ml/kg/h (9-18 mg/kg/min)	ml/kg/h (7-14 mg/kg/min)	From 4 ml/kg/h (7-8.5 mg/kg/min)
Prevention and treatment of hypoglycemia
Rehydration in case of fluid loss and dehydration in patients with high carbohydrate requirements
For dilution and dissolution of parenterally administered drugs	Initial dose: from 50 to 100 ml per dose of the administered drug. Regardless of age. Infusion rate: depending on the drug being diluted. Regardless of age.

*The rate, volume of infusion and duration of treatment depend on the age, body weight, clinical condition and metabolism of the patient, as well as concomitant therapy. They should be determined by a physician experienced in the use of intravenous drugs in children.

Note: Maximum volumes within recommended doses should be administered within 24 hours to avoid hemodilution.

The maximum infusion rate should not exceed the threshold for glucose utilization in the patient's body, as this may lead to hyperglycemia. Depending on the patient's clinical condition, the rate of administration may be reduced to reduce the risk of osmotic diuresis.

When using the drug for diluting and dissolving medications for infusion, the required volume is determined based on the instructions for use of the added medications.

20% glucose solution:

Administration of a 20% glucose solution is carried out only through the central vein. The rate of solution administration is up to 30-40 drops/min (1.5-2 ml/min). The maximum daily dose for adults is 500 ml.

40% glucose solution:

The use of the drug should be carried out under regular medical supervision.

The dosage regimen depends on the age, weight and clinical condition of the patient. Clinical and biological parameters should be carefully monitored, in particular blood glucose concentrations, electrolytes and fluid balance.

A 40% glucose solution is administered intravenously at a rate of up to 30 drops/min (1.5 ml/min).

The maximum daily dose for adults is 250 ml.

After achieving the required concentration of glucose in the blood, the patient is transferred to the administration of 5% or 10% glucose solutions.

Side effects:

Adverse reactions (HP) are grouped by systems and organs in accordance with the MedDRA dictionary and the WHO classification of the incidence of HP development: very often (≥ 1/10), often (≥ 1/100 to<1/10), нечасто (≥ 1/1000 до <1/100), редко (≥ 1/10000 до <1/1000), очень редко (<1/10000), частота неизвестна - (частота не может быть определена на основе имеющихся данных).

From the immune system

Frequency unknown: anaphylactic reactions, hypersensitivity.

Metabolism and nutrition

Frequency unknown: water and electrolyte imbalance (hypokalemia, hypomagnesemia and hypophosphatemia), hyperglycemia, hemodilution, dehydration, hypervolemia.

From the side of blood vessels

Frequency unknown: venous thrombosis, phlebitis.

From the skin and subcutaneous tissues

Frequency unknown: increased sweating.

From the kidneys and urinary tract

Frequency unknown: polyuria.

General and administration site disorders

Not known: chills, fever, injection site infection, injection site irritation, extravasation, injection site tenderness.

Laboratory- instrumentaldata

Frequency unknown: glycosuria.

Adverse reactions may also be related to the drug that was added to the solution. The likelihood of other adverse reactions depends on the properties of the specific drug added.

If undesirable reactions occur, administration of the solution should be stopped.

Overdose:

Symptoms

Long-term infusion of the drug can lead to hyperglycemia, glycosuria, hyperosmolarity, osmotic diuresis and dehydration. Rapid infusion can create fluid accumulation in the body with hemodilution and hypervolemia, and if the body's ability to oxidize glucose is exceeded, rapid infusion can cause hyperglycemia. There may also be a decrease in potassium and inorganic phosphate in the blood plasma.

When dextrose infusion solution is used to dilute and dissolve other intravenous drugs, clinical signs and symptoms of overdose may be related to the properties of the drugs used.

Treatment

If symptoms of overdose appear, the administration of the solution should be suspended, the patient's condition assessed, short-acting insulin administered, and, if necessary, supportive symptomatic therapy.

Interaction:

The combined use of catecholamines and steroids reduces the absorption of dextrose (glucose).

When mixed with other drugs, they must be visually monitored for incompatibility.

For dilution or dissolution of other drugs, the drug should be used only if there are instructions for dilution with dextrose solution in the instructions for use for this drug. In the absence of information on compatibility, the drug should not be mixed with other drugs.

Before adding any drug, it must be ensured that it is soluble and stable in water within the pH range of the drug. After adding a compatible drug to the preparation, the resulting solution should be administered immediately.

Medicines with known incompatibility should not be used.

When administering dextrose solutions through the same infusion system as for blood transfusion, there is a possible risk of hemolysis and thrombosis.

Special instructions:

Since glucose (dextrose) tolerance may be impaired in patients with diabetes mellitus, renal failure, or those in acute critical condition, their clinical and biological parameters should be especially carefully monitored, in particular the concentration of electrolytes in the blood plasma, including magnesium or phosphorus, blood glucose concentration. If hyperglycemia is present, the rate of drug administration should be adjusted or short-acting insulin should be prescribed.

Typically, glucose is completely absorbed by the body (normally it is not excreted by the kidneys), so the appearance of glucose in the urine can be a pathological sign.

In case of prolonged administration or use of dextrose in high doses, it is necessary to monitor the concentration of potassium in the blood plasma and, if necessary, administer additional potassium to avoid hypokalemia.

During episodes of intracranial hypertension, careful monitoring of blood glucose concentrations is necessary.

The use of dextrose solutions can lead to hyperglycemia. Therefore, they are not recommended for administration after acute ischemic stroke, since hyperglycemia is associated with increased ischemic brain damage and impedes recovery.

Particularly careful clinical monitoring is required when starting intravenous administration of the drug.

For rehydration therapy, carbohydrate solutions should be used in combination with electrolyte solutions to avoid electrolyte imbalance (hyponatremia, hypokalemia).

It is necessary to monitor the concentration of glucose and the content of electrolytes in the blood, water balance, as well as the acid-base state of the body.

The solution should be inspected before use. Use only a clear solution without visible inclusions and if the packaging is not damaged. Administer immediately after connecting to the infusion system.

The solution should be administered using sterile equipment in compliance with the rules of asepsis and antisepsis.

To avoid air embolism, remove air from the infusion system using a solution.

Do not connect containers in series to avoid air embolism, which may occur due to air being drawn in from the first container before the solution is administered from the second container.

Delivering intravenous solutions contained in soft plastic containers under increased pressure to increase the flow rate may result in air embolism if residual air in the container is not completely removed before administration.

The use of an IV system with a gas outlet may result in an air embolism if the gas outlet is open. Soft plastic containers should not be used with these systems. Added substances can be administered before infusion or during infusion through the injection site (if there is a special port for drug administration). Adding other drugs to the solution or violating the administration technique may cause fever due to the possible entry of pyrogens into the body. If adverse reactions develop, the infusion should be stopped immediately.

When adding other drugs before parenteral administration, it is necessary to check the isotonicity of the resulting solution. Complete and thorough mixing under aseptic conditions is mandatory. Solutions containing additional substances should be used immediately; their storage is prohibited.

If additional nutrients are administered, the osmolarity of the resulting mixture should be determined before infusion. The resulting mixture must be administered through a central or peripheral venous catheter depending on the final osmolarity.

The compatibility of additionally administered drugs must be assessed before adding them to the solution (similar to the use of other parenteral solutions). Assessing the compatibility of additionally administered drugs with the drug is the responsibility of the physician. It is necessary to check the resulting solution for changes in color and/or the appearance of sediment, insoluble complexes or crystals.

You should study the instructions for use of the added medications.

From a microbiological point of view, the diluted drug should be used immediately. The exception is dilutions prepared under controlled and aseptic conditions. After preparing the solution, the terms and conditions of its storage before administration are the responsibility of the user and should be no more than 24 hours at a temperature of 2 to 8 ° C.

Children

In newborns, especially those born prematurely or with low body weight, the risk of developing hypo- or hyperglycemia is increased, therefore, during the period of intravenous administration of dextrose solutions, careful monitoring of blood glucose concentrations is necessary to avoid long-term undesirable consequences. Hypoglycemia in newborns can lead to prolonged seizures, coma, and brain damage. Hyperglycemia has been associated with intraventricular hemorrhage, delayed bacterial and fungal infections, retinopathy of prematurity, necrotizing enterocolitis, bronchopulmonary dysplasia, prolonged hospitalization, and mortality.

To avoid potentially fatal overdose of intravenous drugs in neonates, special attention must be paid to the route of administration.

When using a syringe pump for intravenous administration of drugs to newborns, the container with the solution should not be left attached to the syringe. When using an infusion pump, all clamps on the system must be closed before removing the system from the pump or turning it off, regardless of whether there is a device in the system that prevents the free flow of fluid.

IV infusion devices and other drug administration equipment should be monitored regularly.

If the drug contains dextrose derived from corn, the drug is contraindicated in patients with a known intolerance to corn or corn products, because The following manifestations of hypersensitivity are possible: anaphylactic reactions, chills and fever.

For drugs in containers:

Containers should be discarded after single use.

Any unused dose should be discarded.

Do not reconnect partially used containers.

Impact on the ability to drive vehicles. Wed and fur.:

Not applicable (due to the use of the drug exclusively in a hospital setting).

Release form/dosage:

Solution for infusion, 5%, 10%, 20%, 40%.

Package:

250 and 500 ml in containers made of multilayer polymer film complete with multilayer polymer tubes and infusion ports.

Each container, along with instructions for use, is placed in an individual bag made of polymer and combined materials.

10-90 containers are placed in a bag of polymer and combined materials along with an equal number of instructions for use, or 10-90 individual bags of containers are placed in a bag of polymer and combined materials (for hospitals only).

Storage conditions:

At temperatures from 5 to 30 °C.

Keep out of the reach of children.

Best before date:

3 years.

Do not use after expiration date.

Conditions for dispensing from pharmacies: On prescription

If you have a child, 1-2 ampoules of 40% glucose, 20 ml each, should always be in the house:

May you never need it - such an ampoule costs about 4 UAH, it is stored for a long time - 3 years, so you will not lose a large amount of money. But if suddenly... then having glucose on hand will help prevent an acetonemic crisis.

Most often, pharmacies offered me glucose produced by Farmak (Kyiv, Ukraine). I once worked as a medical representative in this pharmaceutical company, their quality is good, so I buy without a doubt. Although glucose is a product that is difficult to spoil, so the manufacturer does not play a big role.

There are 10 ampoules of 20 ml in a package, the entire package costs about 37 UAH, but you can buy ampoules individually.

And these ampoules are not only for intravenous administration, you can drink glucose! This is most often recommended when increasing acetone in children.

I have used glucose to increase acetone many times and have found it to be the most effective remedy!

REASONS FOR INCREASED ACETONE.

Why does acetone increase in children? Most common reasons– high temperature, flu, viral infection, poisoning, stress, physical activity. The fact is that Our body needs energy in the form of glucose– it’s like fuel for a gas tank. Glucose accumulates in reserve in the liver and muscles (in the form of glycogen), but children’s energy reserves are small, and if there is an increased consumption of this same energy, then the body runs out of “fuel”. Then it begins to burn fats (which come from food, or its own), and the fats break down into glucose and ketone bodies (acetone).

Lack of energy leads to all processes mentioned above:

Heat

Infectious disease (viral infections, influenza, intestinal infections)

Stress (and even positive stress - guests, parties, holidays, going to the circus)

Physical activity – the child ran, jumped and swam a lot

Too long breaks in eating (for example, lunch 6-8 hours after breakfast without snacks).

This does not happen to all children.

It all depends on how large/small the child’s glycogen reserves are, how quickly his kidneys remove acetone, how well the liver breaks down fats. And this is not a disease! With age, energy reserves increase, the liver and kidneys cope with increasing loads, and everything usually goes away before 5 years, and after 13 - 14 years, acetonemia practically does not occur.

When acetone increases in the blood (and later in the urine), sometimes parents can detect the smell of acetone from the child’s mouth. This smell is reminiscent of apple-fruity. When I hear this smell from a child’s mouth, I know thaturgently need to give glucose!

My child was just one of those whose acetone levels most often rise: thin and very energetic, as they say, “with an awl in the butt.” This does not mean that acetone does not increase in chubby children, but it is much less common in them.

And so, as soon as my son started running and jumping, he urgently needed to be given a sweet drink. Yes, he himself asked for sweets. But if this moment was missed and the smell of rotten apples appeared from my mouth, I already knew: the acetone had increased. Then one ampoule of glucose (read how to give it below) completely solved the problem, and the process did not develop further.

If you don't give glucose, what happens?

A child can be capricious, irritable, and then become lethargic and drowsy. Appetite decreases or disappears. There may be a slight tummy ache and a headache. If this moment is missed, an acetonemic crisis may begin with repeated vomiting. The child will vomit everything that is given to him, even water - and then it will not be possible to give him glucose to drink.

In such cases, doctors advise either drips with glucose, or an injection of a special drug to stop vomiting, and half an hour after the injection You need to urgently give him an ampoule of glucose to drink.

Why an ampoule and not glucose tablets?

Acetone most often increases in children, starting from 10 months of age (sometimes earlier). You won’t give such a baby a pill, and it won’t work at one or two either. And there is often simply no time to grind and dissolve it in water, or prepare a concentrated glucose solution yourself.

Therefore, glucose in ampoules is most convenient as a first aid remedy.

How it works?

Glucose provides rapid replenishment of energy costs, acceleration of metabolic processes and activation of the cleansing function of the liver, promotes the rapid removal of toxins from the body, and provides adequate nutrition to tissues.

You need to give exactly glucose, not fructose!

Where to keep the glucose ampoule?

In the first aid kit, or in the refrigerator (optional).

HOW TO GIVE GLUCOSE TO A CHILD.

- I stored the glucose in the refrigerator, in which case the ampoule needs to be warmed up to body temperature, then it is absorbed very quickly. To do this, you need to put it in a mug with warm (not hot) water for a few minutes.

If the ampoule was stored in a medicine cabinet, you can simply hold the ampoule in your hand, warming it with your warmth.

Then, holding the ampoule in one hand, you need to break off the tip “away from yourself” with the other hand, preferably through a towel, so as not to accidentally cut yourself.

There is no need to wipe the ampoule with anything, you will not be giving an injection.

Turn the ampoule upside down and, tapping the bottom with your finger (or clicking the ampoule with your finger), shake it out - pour the contents into a glass or small cup. There is not much of it, 20 ml is 4 teaspoons. Glucose is clear, like water, but tastes like a very sweet sugar syrup:

Give your child 1 teaspoon every 5 minutes. Can be given directly from a spoon:

If the child is stubborn, use a measuring syringe from an antipyretic, or a regular syringe - a five without a needle. Fill it to the “5” mark and pour it into the child’s mouth, holding the syringe so that the glucose enters the side, behind the cheek, and not directly into the throat.

And so every 5 minutes, 4 times in total.

Remember: if you fail to pour glucose into your mouth, you will have to inject it intravenously!

I was convinced that if everything is done correctly, the child’s condition improves very quickly, he comes to life just before our eyes!

WHAT DRINK AND HOW MANY.

After the child has drunk glucose, wait 10-15 minutes and start feeding. Drink sweet tea, compote, always with sugar (for 1 glass - 3 teaspoons of sugar). Precisely sugar, not honey! The tea can be black, green (only very weak), or chamomile (but also not strong). Compote - fruit or raisin.

Let's drink every 15 minutes.

How much should you drink?

It depends on the weight - you need 120 ml of liquid per 1 kg. That is, if your child weighs 15 kg, he needs to drink 1.8 liters per day (120 times 15 = 1800 ml, or 1.8 liters).

WHAT IS.

DIET.

It's easier to say what is NOT.

When your child has elevated acetone, you need to temporarily exclude animal fats (butter, sour cream, cream, hard “Dutch” cheeses, processed cheeses, full-fat homemade milk, homemade cottage cheese (store-bought low-fat cottage cheese, up to 1% fat content is allowed).

Do not give products containing trans fats (margarine) - these are many store-bought sweets, exclude mayonnaise. Vegetable fats should also be excluded for a while - until recovery.

Remember, fried, smoked, sausage, sausages, canned food, mushrooms are not baby food at all, and even more so if acetone is high.

Also, it is strictly forbidden to add fried foods to soup (for example, onions and carrots fried in vegetable oil). This is not beneficial for an adult either, since it puts a strain on the liver and pancreas, and for a child such food is poison! If dumplings are like boiled food, but you pour onions fried in oil over them - it’s already fried! Or, if the filling contains potatoes/minced meat with fried onions, that’s also fried.

What then is possible?

Porridge with water, or 1% - 1.5% milk with sugar, optionally with raisins

Low-fat 0-1% kefir, low-fat 0-1% cottage cheese with sugar

Boiled potatoes, you can mash them, but without oil (to the mashed potatoes you can add the broth in which the potatoes were boiled, or 1-1.5% milk)

Boiled eggs or steamed omelet (one per day)

Vegetable soups, with vermicelli, potatoes, carrots, rice, buckwheat, you can add diced chicken or turkey fillet, or lean meatballs. But not rich broths!

Boiled meat (but not pork or fatty chicken), preferably beef, chicken/turkey fillet, rabbit;

Meatballs, or steamed cutlets, but not from store-bought minced meat - it contains a lot of fat!

Boiled or baked/steamed sea fish (hake, pollock)

DIAGNOSTICS.

If you cannot detect the smell of acetone from your child’s mouth, use special test strips for acetone (they are called test strips for the determination of ketone bodies). It’s a pity that 25 years ago, when I had a child, these stripes were not available. They are sold in pharmacies and detect acetone in urine.

Pay attention to the expiration date of the strips after opening the bottle and do not use expired strips. You can use test strips that simultaneously detect both sugar in the urine and acetone (they are called glucose and ketone test strips). If both glucose and acetone are elevated on an empty stomach, you should immediately consult a doctor! If only acetone - the child has acetone syndrome described above, and you need to give glucose and call the doctor!

Don't rely too heavily on test strips if you have symptoms.

If the child often hangs from his arms, is lethargic, yawns, is capricious, or vomits once a day, consult a doctor, because even if the test strip does not show anything, this does not mean that the acetone in the blood is normal. A positive reaction of the test strip to acetone, which corresponds to one “+”, means that the level of acetone in the blood is increased 200 times! A negative reaction may mean that the acetone level is increased, but less than 200 times lower (i.e., 150 times, 100 times...)

PREVENTION.

If your child has the flu, fever, or is tired, has been jumping, running, swimming, or has an overabundance of impressions, or is hysterical, a lack of energy may quickly set in. In all these situations, children need glucose. Don’t wait for the smell of acetone to appear on your breath, or, especially, for vomiting! Give us a sweet drink - juice/tea with sugar, Coca-Cola with sugar, because sugar is glucose. If a child wants something sweet, don’t refuse!

Remember, in case of viral diseases (flu, ARVI), especially with fever, you need to drink a lot! Drinks must have sugar.

And then, most often, you will not know what increased acetone is.

Acetone may increase if the child has diabetes. But then the sugar in the urine also increases.

Acetone syndrome can also be a sign of diseases such as diabetes mellitus, thyrotoxicosis, infectious toxicosis, hemolytic anemia, starvation and others. Therefore, if acetone has increased for the first time, you need to determine the blood sugar level, take a biochemical blood test, and, if necessary, consult the child with a gastroenterologist or pediatric endocrinologist.

Your doctor may advise you, in addition to glucose and diet, to give your child Stimol, or Betargin, or Hepargin. Follow your doctor's instructions!

Health to you and your loved ones!

Glucose is a drug for parenteral nutrition, rehydration and detoxification.

Active substance

Release form and composition

The drug is available in the form of a solution for infusion with a concentration of 50 g and 100 g per 1 liter.

Indications for use

The drug is indicated for hypoglycemia, carbohydrate deficiency, for rapid fluid replenishment during cellular, extracellular and general dehydration.

Glucose solution is also used as a component of blood replacement and anti-shock fluids and the basis for the preparation of drugs for intravenous administration.

Contraindications

Contraindications include:

• hyperglycemia;
• overhydration;
• hyperosmolar coma;
• hyperlactic acidemia;
• postoperative disorders of dextrose utilization;
• circulatory disorders that threaten cerebral and pulmonary edema;
• cerebral edema;
• pulmonary edema;
• acute left ventricular failure;
• increased sensitivity.

Glucose is used with caution in decompensated chronic heart failure, chronic renal failure, hyponatremia, and diabetes mellitus.

Instructions for use Glucose (method and dosage)

Glucose is administered intravenously, dropwise, in a dosage appropriate to age, body weight and clinical condition, or intravenously in small doses.

For intravenous drip administration to adults, ml of the drug per day is indicated. Children weighing up to 10 kg – 100 ml per 1 kg of body weight per day. Children weighing kg – 1000 ml +50 ml for each kg over 10 kg per day. Children weighing more than 20 kg – 1500 ml +20 ml for each kg over 20 kg per day. The rate of administration is up to 5 ml per 1 kg of body weight per hour.

Side effects

Side effects of Glucose include fever and local inflammation of tissue in the injection area. Violation of the administration technique can provoke thrombosis or thrombophlebitis.

Overdose

If the recommended dose is exceeded, persistent hyperglycemia and glucosuria develop. Hyperglycemic or hyperosmolar coma is possible. Overhydration, water-electrolyte imbalance, and acute left ventricular failure are also possible.

If symptoms appear, the drug is discontinued, short-acting insulin is administered, and symptomatic therapy is prescribed.

Analogs

Analogs by ATC code: Glucose solution for infusion, Dextrose.

Do not decide to change the drug on your own; consult your doctor.

pharmachologic effect

Entering the tissues, dextrose is converted into glucose-6-phosphate, which is actively involved in many metabolic processes and partially replenishes water deficiency. A 5% dextrose solution is isotonic to blood plasma.

Dextrose is absorbed completely by the body and is not excreted by the kidneys.

special instructions

The drug should not be administered simultaneously with blood preserved with sodium citrate.

In patients with significant electrolyte loss, infusions of large volumes of dextrose are dangerous. Monitoring of electrolyte balance is required.

When a 5% dextrose solution is combined with a 0.9% sodium chloride solution, the osmolarity of the drug increases. Monitoring of blood glucose concentration is necessary.

To improve the absorption of dextrose, you can combine the drug with 4-5 units of short-acting insulin at the rate of 1 unit of insulin per 4-5 g of dextrose.

The drug does not affect the ability to drive vehicles.

During pregnancy and breastfeeding

Prescribed according to indications.

In childhood

Prescribed according to indications in accordance with the recommended dose.

In old age

Drug interactions

Visual control of compatibility is required when adding drugs to a glucose solution.

Conditions for dispensing from pharmacies

Dispensed by prescription.

Storage conditions and periods

Store in a place protected from light, out of reach of children, at a temperature not exceeding 25 °C. Freezing is acceptable, after which it is necessary to keep the solution at a temperature of +15...+25 °C until completely defrosted. If the contents of the container become cloudy, do not use. Shelf life – 2 years.

Price in pharmacies

The price of Glucose for 1 package starts from 17 rubles.

The description posted on this page is a simplified version of the official version of the annotation for the drug. The information is provided for informational purposes only and does not constitute a guide for self-medication. Before using the medicine, you must consult a specialist and read the instructions approved by the manufacturer.

Glucose tablets 0.5 g 10 pcs.

Glucose 500 mg No. 20 tablets

Glucose solution for inf 5% 200 ml Grotex

Glucose solution 5% 250 ml

Glucose solution for infusion 10% 200 ml bottle

Ruslan, hello, did they answer you?

When using materials from the site, the active reference is obligatory.

The information presented on our website should not be used for self-diagnosis and treatment and cannot serve as a substitute for consultation with a doctor. We warn you about the presence of contraindications. Specialist consultation is required.

Glucose 10ml (40%) Dextrose

Instructions

• Russian
• Kazakh

Tradename

International nonproprietary name

Dosage form

Solution for injection 40%, 10 ml and 20 ml

Compound

1 ml of solution contains

active ingredients: glucose monohydrate 0.4 g in terms of anhydrous glucose

excipients: 0.1 M hydrochloric acid, sodium chloride, water for injection

Description

Transparent colorless or slightly yellowish liquid

Pharmacotherapeutic group

Plasma replacement and perfusion solutions. Other irrigation solutions. Dextrose.

Code ATX В05C Х01

Pharmacological properties

After intravenous administration, glucose enters the organs and tissues through the bloodstream, where it is included in metabolic processes. Glucose reserves are stored in the cells of many tissues in the form of glycogen. Entering the process of glycolysis, glucose is metabolized to pyruvate or lactate; under aerobic conditions, pyruvate is completely metabolized to carbon dioxide and water, producing energy in the form of ATP. The end products of complete oxidation of glucose are excreted by the lungs and kidneys.

Glucose provides substrate replenishment of energy expenditure. When hypertonic solutions are injected into a vein, intravascular osmotic pressure increases, the flow of fluid from tissues into the blood increases, metabolic processes accelerate, the antitoxic function of the liver improves, the contractile activity of the heart muscle increases, and diuresis increases. When a hypertonic glucose solution is administered, redox processes are enhanced and glycogen deposition in the liver is activated.

Indications for use

hypoglycemia (low blood sugar)

Directions for use and doses

Glucose solution 40% is administered intravenously very slowly (single dose), for adults – one dose at a time. If necessary, administer dropwise at a rate of up to 30 drops/min. The dose for adults with intravenous drip administration is up to 300 ml per day (6.0 g of glucose per 1 kg of body weight).

Side effects

pain at the injection site, venous irritation, phlebitis, venous thrombosis

hyperglycemia, hypokalemia, hypophosphatemia, hypomagnesemia, glycosuria, acidosis

allergic reactions (fever, skin rashes, angioedema, shock)

Contraindications

hypersensitivity to the components of the drug

intracranial and subarachnoid hemorrhage in the spinal cord, with the exception of conditions associated with hypoglycemia

severe dehydration, including delirium tremens

diabetes mellitus and other conditions accompanied by hyperglycemia

glucose-galactose malabsorption syndrome

cerebral edema and pulmonary edema

acute left ventricular failure

Drug interactions

Glucose solution 40% should not be administered in the same syringe with hexamethylenetetramine, since glucose is a strong oxidizing agent. It is not recommended to mix in one syringe with alkaline solutions: with general anesthetics and sleeping pills, as their activity decreases, solutions of alkaloids; inactivates streptomycin, reduces the effectiveness of nystatin.

Under the influence of thiazide diuretics and furosemide, glucose tolerance decreases. Insulin promotes the entry of glucose into peripheral tissues, stimulates the formation of glycogen, the synthesis of proteins and fatty acids. Glucose solution reduces the toxic effect of pyrazinamide on the liver. The administration of a large volume of glucose solution contributes to the development of hypokalemia, which increases the toxicity of simultaneously used digitalis preparations.

special instructions

The drug should be used under control of blood sugar and electrolyte levels.

The drug should not be administered simultaneously with blood products.

It is not recommended to prescribe glucose solution in the acute period of severe traumatic brain injury, in case of acute cerebrovascular accident, since the drug can increase damage to brain structures and worsen the course of the disease (except in cases of correction of hypoglycemia).

In case of hypokalemia, the administration of glucose solution must be combined with the correction of potassium deficiency (due to the risk of increased hypokalemia).

For better absorption of glucose in normoglycemic conditions, it is advisable to combine the administration of the drug with the administration of (subcutaneous) short-acting insulin at the rate of 1 unit per 4-5 g of glucose (dry matter).

Do not use the solution subcutaneously or intramuscularly.

The contents of the ampoule can only be used for one patient; after the seal of the ampoule is broken, the unused solution should be discarded.

In case of renal failure, decompensated heart failure, hyponatremia, special caution and monitoring of central hemodynamic parameters are required.

Use during pregnancy or lactation

Glucose infusions in pregnant women with normoglycemia can lead to fetal hyperglycemia and cause metabolic acidosis. The latter is important to consider, especially when fetal distress or hypoxia is already caused by other perinatal factors.

Use in pediatrics

The drug is used in children only as prescribed and under the supervision of a physician.

Features of the drug's influence on the ability to drive vehicles or operate potentially dangerous mechanisms

Overdose

Symptoms: hyperglycemia, glycosuria, increased osmotic blood pressure (up to the development of hyperglycemic coma), overhydration and electrolyte imbalance.

Treatment: the drug is discontinued and insulin is prescribed at the rate of 1 unit for every 0.45-0.9 mmol of blood glucose until the blood glucose level reaches 9 mmol/l. Blood glucose levels should be reduced gradually. At the same time as insulin is prescribed, an infusion of balanced salt solutions is carried out.

If necessary, symptomatic treatment is prescribed.

Release form and packaging

10 ml or 20 ml in glass ampoules with a break ring or break point. 5 or 10 ampoules, along with instructions for medical use in the state and Russian languages, are placed in a pack with corrugated cardboard inserts.

Or 5 ampoules are placed in a blister pack made of polymer film. 1 or 2 blister packs of ampoules along with instructions for medical use in the state and Russian languages ​​are placed in a cardboard pack.

Storage conditions

Store at a temperature not exceeding 25 °C.

Keep out of the reach of children!

Shelf life

Do not use the drug after the expiration date indicated on the package

Conditions for dispensing from pharmacies

Manufacturer

Public Joint Stock Company "Farmak"

Ukraine, 04080, Kyiv, st. Frunze, 63.

Registration Certificate Holder

Public Joint Stock Company "Farmak", Ukraine

Address of the organization that accepts claims from consumers regarding the quality of products (products) on the territory of the Republic of Kazakhstan

Republic of Kazakhstan, Almaty, st. Abaya 157, office 5

Glucose 20%

Manufacturer: Farmland LLC, Republic of Belarus

ATS code: В05СХ01

Release form: Liquid dosage forms. Solution for infusion.

General characteristics. Compound:

Active ingredient: 200 g of glucose in terms of anhydrous in 1 liter of infusion solution.

Excipients: sodium chloride.

Pharmacological properties:

Pharmacodynamics. When hypertonic solutions (20%, 30%, 40%) are injected into a vein, the osmotic pressure of the blood increases, the flow of fluid from tissues into the blood increases, metabolic processes increase, the antitoxic function of the liver improves, the contractile activity of the heart muscle increases, blood vessels dilate, and diuresis increases. .

Indications for use:

20% glucose solutions are used for hypoglycemia and liver diseases (hepatitis, cirrhosis, hepatic coma), for osmotherapy with insufficient diuresis, collapse and shock, for severe infectious diseases, cardiac decompensation, various intoxications (poisoning with drugs, cyanides, carbon monoxide and etc.), with hemorrhagic diathesis. Total parenteral nutrition or partial. Glucose solutions can be used either independently or according to indications in combination with other medicinal substances (sodium chloride, potassium chloride, NaEDTA, etc.), and can also be used for diluting drugs.

Directions for use and dosage:

Hypertonic glucose solution (20%) is administered only into a vein, once or drip up to 300 ml per day. If necessary, large volumes of hypertonic glucose solution can be administered. For more complete absorption of glucose administered in large quantities, insulin is prescribed simultaneously with it at the rate of 1 unit of insulin per 4-5 g of glucose. For diabetic patients, glucose is administered with caution, under the control of sugar levels in the blood and urine.

Features of application:

With repeated administration of the solution, disturbances in the functional state of the liver and depletion of the insular apparatus of the pancreas are possible. Due to the increase in osmotic pressure of the blood, a 20% solution is injected into the central vein using a catheter.

Contraindications:

A relative contraindication is hyperglycemia in diabetes mellitus.

Overdose:

In case of an overdose of hypertonic glucose solutions, hyperglycemia may develop. To correct it, insulin is used, and symptomatic therapy is also carried out.

Storage conditions:

In a place protected from moisture and light at a temperature from +5 to +30 °C. Shelf life: 2 years.

Vacation conditions:

Package:

100, 250 or 500 ml in polymer containers for infusion solutions.

Similar drugs

Plasma replacement drugs. Dextran.

Tissue regeneration stimulator

Solutions for intravenous administration. Carbohydrates.

Solutions for intravenous administration. Irrigation solutions.

Plasma replacement agent, parenteral nutrition agent

Solutions for parenteral nutrition.

Means for therapeutic nutrition. Carbohydrates.

A drug with a reflex vasodilator effect.

Glucose injection solution 40%, 20 ml in ampoules No. 5

Dosage form: Solutions for internal use

general characteristics

international and chemical names: glucose; (+)-D-glucopyranosine monohydrate;

Basic physical and chemical properties

colorless or slightly yellowish, transparent liquid;

Compound

1 ml of solution contains 0.4 g of glucose in terms of anhydrous glucose;

excipients: 0.1 M solution of hydrochloric acid, sodium chloride, water for injection.

Release form

Injection.

Pharmacotherapeutic group

Solution for intravenous administration. Carbohydrates. ATC code B05C X01.

Pharmacological properties

Pharmacodynamics. Glucose provides substrate replenishment of energy expenditure. When hypertonic solutions are injected into a vein, intravascular osmotic pressure increases, the flow of fluid from tissues into the blood increases, metabolic processes accelerate, the antitoxic function of the liver improves, the contractile activity of the heart muscle increases, and diuresis increases. When a hypertonic glucose solution is administered, redox processes are enhanced and glycogen deposition in the liver is activated.

Pharmacokinetics. After intravenous administration, glucose enters the organs and tissues through the bloodstream, where it is included in metabolic processes. Glucose reserves are stored in the cells of many tissues in the form of glycogen. Entering the process of glycolysis, glucose is metabolized to pyruvate or lactate; under aerobic conditions, pyruvate is completely metabolized to carbon dioxide and water with the formation of energy in the form of ATP. The end products of complete oxidation of glucose are excreted by the lungs and kidneys.

Indications for use

Directions for use and doses

Glucose solution 40% is administered intravenously (very slowly), for adults - half a minute per injection. If necessary, administer dropwise at a rate of up to 30 drops/min (1.5 ml/kg/h). The dose for adults with intravenous drip administration is up to 300 ml per day. The maximum daily dose for adults is 15 ml/kg, but not more than 1000 ml per day.

Side effect

With rapid intravenous administration, phlebitis may develop. Ionic (electrolyte) imbalance may develop.

Contraindications

Diabetes mellitus and various conditions accompanied by hyperglycemia.

Overdose

In case of an overdose of the drug, hyperglycemia, glycosuria, increased osmotic blood pressure (up to the development of hyperglycemic hyperosmotic coma), hyperhydration and electrolyte imbalance develop. In this case, the drug is discontinued and insulin is prescribed at the rate of 1 unit for every 0.45–0.9 mmol of blood glucose until the blood glucose level reaches 9 mmol/l. Blood glucose levels should be reduced gradually. At the same time as insulin is prescribed, an infusion of balanced salt solutions is carried out.

Features of application

The drug should be used under control of blood sugar and electrolyte levels. It is not recommended to prescribe glucose solution in the acute period of severe traumatic brain injury, in case of acute cerebrovascular accident, since the drug can increase damage to brain structures and worsen the course of the disease (except in the case of correction of hypoglycemia).

In case of hypokalemia, the administration of a glucose solution must be combined with the correction of potassium deficiency (due to the risk of increased hypokalemia).

Glucose infusions in pregnant women with normoglycemia can cause hyperglycemia in the fetus and cause metabolic acidosis. The latter is important to consider, especially when fetal distress or hypoxia is already caused by other perinatal factors.

For better absorption of glucose in normoglycemic conditions, it is advisable to combine the administration of the drug with the administration (subcutaneously) of short-acting insulin at the rate of 1 unit of glucose (dry matter).

Interaction with other drugs

Due to the fact that glucose is a fairly strong oxidizing agent, it should not be administered in the same syringe with hexamethylenetetramine. It is not recommended to mix glucose solution in the same syringe with alkaline solutions: with sleeping pills (their activity decreases), solutions of alkaloids (they disintegrate). Glucose also weakens the effect of analgesics, adrenergic agonists, and inactivates streptomycin.

Conditions and shelf life

Store out of the reach of children at a temperature not exceeding 25 °C. Shelf life – 5 years.

Vacation conditions

Package

10 ml or 20 ml in an ampoule. 5 or 10 ampoules per pack.

Manufacturer

Address

04080, Ukraine, Kyiv, st. Frunze, 63.

Only registered users can leave a comment (Login and Register)

Similar drugs:

New specializations of doctors:

New disease terminologies:

The information in the directory is provided for informational purposes only and is taken from open sources. If you have questions regarding the nature of the disease and the correct method of diagnosis and treatment, we recommend that you consult a doctor.

Before purchasing and using drugs, it is STRONGLY recommended that you consult a doctor and first read the official leaflet of the drug from the manufacturer. The final decision on prescribing the drug and determining the dose size can only be made by a specialist.

Our site is not responsible for the consequences caused by the use of posted information.

The drug is glucose 20, 40, 5 and 10%.

Glucose in the form of tablets is a drug that is intended for oral nutrition of a sick person. This substance has a hydrating and detoxifying effect on the body.

Pharmaceutical companies produce glucose in the form of tablets or solution for intravenous injection, and the instructions for use in these cases are somewhat different.

The main active ingredient in the drug is dextrose monohydrate, the content of which can be:

• 1 tablet – 50 mg;
• 100 ml of solution – 5, 10, 20 or 40 g.

For example, the composition of a glucose solution also includes auxiliary substances. For this, hydrochloric acid and water for infusion are used, all this is taken into account in the instructions for use of the drug.

Due to the fact that the price of glucose tablets and solution is minimal, they can be taken by all segments of the population.

Dextrose monohydrate can be purchased at pharmacies in the form:

1. tablets (in blisters of 10 pieces);
2. injection solution: in plastic containers (50, 100, 150, 250, 500 or 1000 ml volume), glass bottle (100, 200, 400 or 500 ml volume);
3. solution for intravenous administration in glass ampoules (5 ml or 10 ml).

Why is glucose needed?

The instructions for use indicate that taking tablets or a solution is necessary to qualitatively replenish carbohydrate deficiency in the body, which can occur against the background of various pathological conditions.

The main thing is not to take pills if you are diagnosed with diabetes.

In addition, glucose can be used for:

• intoxication of the body;
• correcting dehydration that occurs after surgery or after prolonged diarrhea;
• hemorrhagic diathesis;
• collapse;
• state of shock;
• hypoglycemia;
• hepatitis;
• liver failure;
• liver dystrophy or atrophy.

Main contraindications

It is strictly prohibited to use glucose solution and tablets in situations where the patient’s medical history indicates the following functional disorders:

Intravenous administration of the drug should be done with extreme caution in the following cases:

• chronic renal failure;
• decompensated heart failure (chronic);
• hyponatremia.

It is important to know that glucose is strictly contraindicated in diabetes mellitus, acute left ventricular failure, swelling of the brain or lungs. Prescribed with caution to children.

The drug cannot yet be used in case of hyperhydration, as well as circulatory pathology with a high probability of developing cerebral and pulmonary edema. The price of the drug does not affect its contraindications.

How to use and dose?

If the Glucose solution must be administered intravenously, the attending physician will independently determine the volume of the substance for the drip or jet method.

According to the instructions, the maximum daily dose (with infusion) for an adult patient will be:

• 5 percent dextrose solution - 200 ml at an injection rate of 150 drops per minute or 400 ml per 1 hour;
• 0 percent solution – 1000 ml at an injection rate of 60 drops per minute;
• 20 percent solution – 300 ml at a speed of up to 40 drops;
• 40 percent solution – 250 ml with a maximum injection rate of up to 30 drops per minute.

If there is a need to administer Glucose to pediatric patients, then its dose will be set based on the child’s weight and cannot exceed the following indicators:

1. weight up to 10 kg – 100 ml per kilogram of weight in 24 hours;
2. weight from 10 to 20 kg - to the volume of 1000 ml you need to add 50 ml for each kilogram over 10 kg of weight in 24 hours;
3. weight more than 20 kg - to 1500 ml you need to add 20 ml for every kilogram of weight over 20 kg.

With intravenous jet administration of 5 or 10 percent solutions, a single dose of 10 to 50 ml will be prescribed. The price of tablets and solution differs; as a rule, the price of tablets is lower.

When receiving Glucose as a base substance during the parenteral administration of other drugs, the volume of the solution must be taken from 50 to 250 ml per 1 dose of the administered drug.

The rate of administration will be determined by the characteristics of the drug dissolved in Glucose.

Side effects

According to the instructions, Glucose will not have a negative effect on the patient’s body. This will be true provided that it is prescribed correctly and the established rules of use are followed.

Side effects include:

• fever;
• polyuria;
• hyperglycemia;
• acute left ventricular failure;
• hypervolemia.

There is a high likelihood of pain at the injection site, as well as local reactions, for example, infections, bruising, thrombophlebitis.

Glucose can be used during pregnancy and lactation. The price of the drug does not change depending on its use.

If a combination with other drugs is necessary, their compatibility should be determined visually.

It is important to mix medications immediately before infusion. Storage of the prepared solution and its use is strictly prohibited!

Interesting fact: The human eye is so sensitive that if the Earth were flat, a person could notice a candle flickering in the night at a distance of 30 km.

Interesting fact: The Egyptian pharaohs used leeches; in ancient Egypt, researchers found images of leeches carved on stones, as well as scenes of their treatment.

Interesting fact: The human nose is a personal air conditioning system. It heats cold air, cools hot air, and traps dust and foreign bodies.

Interesting fact: The most common infectious disease in the world is dental caries.

Interesting fact: Men are about 10 times more likely than women to suffer from color blindness.

Interesting fact: Three quarters of the bacterial species living in the human intestine have not yet been discovered.

Interesting fact: The weight of the heart at the age of 20–40 years on average reaches 300 g in men, 270 g in women.

Fun fact: Babies are born with 300 bones, but this number drops to 206 by adulthood.

Interesting fact: Only humans and dogs can get prostatitis.

Interesting fact: Children whose fathers smoke are 4 times more likely to get leukemia.

Interesting fact: A person can go longer without food than without sleep.

Interesting fact: Diabetes ceased to be a deadly disease only in 1922, when insulin was discovered by two Canadian scientists.

Interesting fact: Viagra was invented by accident during the development of a drug to treat heart disease.

Interesting fact: The liver breaks down alcohol most effectively between 6 and 8 p.m.

Interesting fact: The heaviest human organ is the skin. In an adult of average build, it weighs about 2.7 kg.

Glucose (from the Latin “glucos” - sweet) is a carbohydrate; a crystalline substance, colorless and odorless, with a sweetish taste, highly soluble in water. Synonyms: grape sugar, dextrose.

In the form of medical preparations, glucose is a variety of means for artificial additional therapeutic nutrition (enteral (through the gastrointestinal tract) and parenteral (bypassing the gastrointestinal tract)).

Release forms and composition

Glucose is available in the following dosage forms:

• tablets of 0.5 g each, packed in 10 pieces in blister packs and placed in 1, 2, 3, 5 or 10 pieces in a cardboard box; tablets of 0.5 g, packaged in 10 pieces in cell-free packaging;
• 5%, 10%, 20%, 40% solution for infusion in polymer containers, glass or polyethylene bottles of 200, 250, 400, 500 and 1000 ml of solution each;
• 5%, 10%, 25%, 40% solution for intravenous administration in ampoules of 5, 10 and 20 ml. Each cardboard package contains 5 or 10 ampoules.

The active ingredient in all dosage forms of the drug is dextrose monohydrate, that is, dry glucose in combination with excipients.

Each tablet contains 0.5 g of dry dextrose.

Each liter of 5% glucose infusion solution contains 50 g of dry dextrose, 10% g solution, 20% g solution, 40% g solution.

Each milliliter of 5% glucose solution for intravenous administration contains 50 mg of anhydrous (dry) dextrose, 10% mg, 25% mg, 40% mg.

pharmachologic effect

Glucose is a means of carbohydrate nutrition. The pharmacological action of drugs based on it is aimed at improving metabolic processes in the body and enhancing redox processes in it.

The 5% glucose solution, which is most often used, is isotonic with respect to blood plasma, its infusion helps to partially eliminate the body's water deficiency and replenish blood volumes. Glucose solution 5% is also a valuable nutrient material for blood plasma.

10% - 40% solutions are called hypertonic. when administered intravenously, they increase the osmotic pressure of the blood, enhance the outflow of fluid from tissues, increase urine formation, have a beneficial effect on the contractile function of the heart muscle, dilate blood vessels, and activate metabolic processes in the liver, in particular its ability to neutralize toxic compounds.

Glucose tablets have a moderate sedative and vasodilator effect. Once in the body, it provides it with a significant amount of additional energy at the cellular level and, thus, increases physical and intellectual productivity.

Indications for use of Glucose

In medical practice, glucose tablets and solutions are used for hypoglycemia (low levels of glucose (sugar) in the blood), as well as as additional nutrition during and after illnesses (including infectious ones), which, in addition to general weakness of the body, can also provoke a decrease in glucose levels.

Glucose is used as an auxiliary treatment for cardiac decompensation and hemorrhagic diathesis. intestinal infectious diseases. In order to improve the blood supply to organs, it is used in case of a sudden drop in blood pressure (collapse), as well as in the disorder of the vital functions of the body after a shock, in case of dehydration (dehydration) in order to restore water balance.

Careful intravenous administration of a 5% glucose solution can significantly improve the condition of a patient with pulmonary edema.

When the level of glucose in the blood is insufficient, the liver suffers first of all; glucose preparations are used to maintain it, as well as for the purpose of auxiliary treatment of various liver diseases (hepatitis, dystrophy, atrophy).

Treatment of various intoxications and poisonings, including poisoning with drugs, acids, arsenic, carbon monoxide, aniline, phosgene, etc., is not possible without infusion of a 5% glucose solution.

In addition, glucose is used as a basis for diluting various medicines.

Glucose solution 5% is an isotonic solution; it is administered into the human body:

• subcutaneously (up to 500 ml at a time);
• intravenously in the form of infusions (minimum 300 ml of solution, maximum 2000 ml);
• in the form of enemas (ml of solution).

For hypertonic glucose solutions of 10, 25, 40%, only intravenous infusion is used (20-50 ml of solution per injection). In case of a serious condition of the patient, with catastrophically low glucose levels, hypertonic solutions are administered using drip infusions (in other words, used in the form of droppers) up to 300 ml of solution per day.

To achieve a better therapeutic effect, glucose preparations are combined with insulin. ascorbic acid. and in case of poisoning with a solution of methylene blue.

Glucose tablets are taken orally; 1-2 tablets are usually used at one time, but if necessary, the dose is increased to 10 or more tablets. The number of appointments depends on the patient’s condition, usually 3 appointments per day are required. The tablets are taken an hour before meals; if necessary, they can be chewed, bitten or dissolved.

Contraindications to the use of Glucose and its side effects

The main contraindication to the use of glucose preparations is diabetes mellitus. as well as other conditions that are accompanied by high blood sugar levels. The use of glucose during pregnancy and breastfeeding is permitted after consulting a doctor.

Possible side effects during or after using glucose:

• decreased appetite;
• overhydration. occurred as a result of infusion of an excessive amount of solution;
• phlebitis, thrombosis and thrombophlebitis. resulting from violation of asepsis or administration technique;
• tissue inflammation at the sites where the solution was administered;
• hypervolemia resulting from an excessive increase in blood volume;
• acute failure of the left ventricle of the heart;
• with repeated use - dysfunction of the liver and insular apparatus.

Glucose during pregnancy

Against the background of serious physiological changes in the body of a pregnant woman, surges in blood glucose levels are in most cases considered normal. Most often, pregnant women experience hyperglycemia (increased glucose levels), but periods when a woman feels tired, has increased sweating, her hands tremble, and there is a constant feeling of hunger may well indicate a temporary decrease in blood glucose levels.

The benefit of glucose for the fetus lies in its nutritional properties. Droppers with a 5% glucose solution are prescribed to women if they suspect a small fetus. As practice shows, the use of glucose during pregnancy has a very good effect on the weight of the unborn child.

There is also an opinion that consuming glucose during pregnancy reduces the risk of miscarriages and premature birth.

Attention! The description of the drug posted on this page is a simplified version of the official version of the annotation for the drug. The information is provided for informational purposes only and does not constitute a guide for self-medication. Before using the drug, you must consult a specialist and read the instructions approved by the manufacturer.

general information

Glucose is a carbohydrate that is the main energy product for the human body. An aqueous solution of glucose is used when there is a need to replenish the body with fluid, remove toxins or provide it with nutrients.

Composition and release form

One hundred milliliters of 40% solution for injection contains forty grams of glucose. One hundred milliliters of a 5% solution contains five milligrams of the active substance. The drug is produced in the form of a 40% solution for infusion in glass bottles with a capacity of 100, 200, 250, 400 and 500 ml. They are packaged in cardboard boxes with instructions for use of the drug. The product is also available in plastic bags.

40% of the drug is available in ampoules of ten and twenty milliliters, which are packed in a cardboard box. Each box contains ten ampoules for intravenous administration. There are also instructions for using the drug.

pharmachologic effect

Isotonic glucose solution 5% is used to replenish the human body with fluid. In addition, it is an excellent source of easily digestible carbohydrates. For normal functioning of the body, a huge amount of energy is needed, which is easily released during the metabolism of this carbohydrate.

The use of the product for the purpose of rehydration is quite justified. With intravenous administration of 10%, 20% or 40% solution, which are hypertonic, the osmotic pressure of the blood increases significantly, and fluid from the tissues rushes into the bloodstream. This helps stimulate metabolic processes in the body, significantly improves the detoxification function of the liver, enhances the contractility of the heart muscle, dilates blood vessels, including the kidneys, which leads to increased diuresis.

Indications

The use of the drug is indicated in the following cases:

to compensate for the lack of carbohydrates in the body;

for the purpose of correcting dehydration when the body loses fluid due to vomiting and diarrhea, as well as in the postoperative period;

during detoxification infusion therapy;

as a component of various anti-shock and blood-substituting fluids in the treatment of collapse and shock;

for the preparation of various solutions of drugs for intravenous injections and infusions.

Glucose solution for newborns is used in the following cases:

with a reduced content of this carbohydrate, which is detected in the child’s blood immediately after birth;

in case of lack or absence of milk from the mother;

with asphyxia of newborns;

if there is a birth injury to the head and back of the newborn, which caused disturbances in the respiratory function and functioning of the cardiovascular system.

Contraindications

The use of the drug is contraindicated for the following diseases:

hyperglycemia and diabetes mellitus;

hyperlactic acidemia and overhydration;

postoperative disorders of glucose utilization;

circulatory disorders that threaten cerebral and pulmonary edema;

swelling of the brain or lungs;

acute left ventricular failure;

Side effect

An intravenous glucose solution can cause an imbalance in ion balance or hyperglycemia. Complications from the cardiovascular system are also possible, which are manifested by hypervolemia and acute left ventricular failure. In rare cases, a fever may develop. At the injection site, irritation and the development of infectious complications and thrombophlebitis are possible.

Overdose

Overdose may increase side effects. In some cases, tachypnea (rapid breathing) and pulmonary edema develop. Hyperglycemia and overhydration may also develop.

Interaction with other drugs

When using a glucose solution simultaneously with furasemide and thiazide diuretics, it should be taken into account that they can affect the level of this carbohydrate in the blood serum.

Insulin helps glucose quickly reach peripheral tissues. It also stimulates glycogen production, fatty acid and protein synthesis. Glucose solution significantly reduces the toxic effects of pyrazinamide on the liver. When a large amount of the drug is administered, hypokalemia (a decrease in the level of potassium in the blood serum) may develop, and this increases the toxicity of digitalis preparations if they are used simultaneously with glucose.

There is information about the incompatibility of this drug with drugs such as aminophylline, soluble barbiturates, erythromycin, hydrocortisone, kanamycin, soluble sulfonamide drugs and cyanocobalamin.

In case of overdose, the patient should be treated symptomatically, the blood glucose level should be determined and insulin should be administered in appropriate doses.

Special instructions and precautions

Solutions of sucrose and glucose can be administered intravenously if indicated for pregnant and breastfeeding women. In chronic renal failure with oligoanuria (decreased amount of urine excreted), the drug is used with caution.

An individual approach is taken to prescribing an isotonic or hypertonic glucose solution to patients with decompensated heart failure, chronic renal failure, which is manifested by anuria (cessation of urine filtration), and with a decrease in the concentration of sodium in the blood serum (hyponatremia).

In order to increase osmolarity, it is recommended to combine a 5% dextrose solution with a 0.9% (isotonic) sodium chloride solution.

The drug should be stored in vials, plastic containers or glass ampoules in a place where children will not find it. After opening the vial, bottle or ampoule, the solution must be used immediately. It is not allowed to store leftover unused sucrose or glucose solution. It must be disposed of immediately.

The price of a drug for intravenous administration depends on its concentration, the capacity of the bottle or ampoule and the manufacturer. We bring to your attention the average prices for glucose solution:

A 5% solution in 250 ml bottles costs 27.00 rubles.

One bottle of 5%, with a capacity of 500 ml can be purchased at a price of 35.00 rubles

Glucose 5% solution for infusion, capacity 200 ml, costs 33.00 rubles.

The cost of a plastic bag of 5% solution with a capacity of 500 ml is 37.00 rubles.

Ten ampoules of a 40% solution produced in the Russian Federation cost 43.50 rubles.

You can buy glucose solution for intravenous infusion in a pharmacy chain without a doctor's prescription. This drug can also be ordered in online pharmacies.

Glucose solution is used for diseases:

Mode of application

The drug is usually administered intravenously. When administering an isotonic (5%) solution, the infusion rate should not exceed 150 drops per minute. For adult patients, no more than two liters can be administered.

A ten percent solution is administered intravenously at a rate not exceeding sixty drops per minute. The maximum permissible daily dose for adults is five hundred milliliters.

When administering a twenty percent solution intravenously, the rate should not exceed forty drops per minute, and the maximum daily volume for adults should not exceed three hundred milliliters.

A forty percent hypertonic solution is administered at a maximum rate of thirty drops per minute. You can administer no more than two hundred and fifty milliliters.

Doctors use an isotonic 5% glucose solution for newborns mainly to replenish fluid loss in the body. Also, this carbohydrate is a source of nutrients and energy, so necessary for the full functioning of the child’s body.

Glucose solution for newborns is one of the tools for saving a child’s life. Depending on how severe the baby’s condition is, the drug is administered to newborns through a tube, intravenously, or given in a bottle. It should be remembered that if a woman who has given birth to a healthy baby does not have a deficiency of breast milk, and a breastfeeding regimen is immediately established, the drug is not prescribed. Giving sucrose and glucose solutions to a newborn without a pediatrician’s instructions is strictly prohibited.

Hair coloring. Safe hair dyes

Summer ponds: to swim or not?

What can you do with a 5 year old child at home that will benefit him?

Infantile colic

2018 Be Healthy. The site administration is not responsible for the consequences and results that readers may receive after using the information on our site! Consult your doctor. All copyrights to materials belong to their respective owners