Veroshpiron indications for use analogues. Veroshpiron - indications for use and important features of the diuretic. Interaction with other drugs

P N011953/01

Trade name of the drug: Veroshpiron

International nonproprietary name:

spironolactone

Dosage form:

capsules

COMPOUND
1 capsule contains:
Capsules 50 mg
Active substance: spironolactone - 50.00 mg
sodium lauryl sulfate - 2.50 mg; magnesium stearate - 2.50 mg; corn starch - 42.50 mg; lactose monohydrate - 127.50 mg.
Hard gelatin capsule:
Size No. 3.
Cap: quinoline yellow dye E 104 - 0.48%; titanium dioxide E 171 - 2.0%; gelatin - up to 100%.
Frame: titanium dioxide E 171 - 2.00%; gelatin - up to 100%.
Capsules 100 mg
Active substance: spironolactone - 100.00 mg.
Excipients in the capsule: sodium lauryl sulfate - 5.00 mg; magnesium stearate - 5.0 mg; corn starch - 85.00 mg; lactose monohydrate - 255.00 mg.
Hard gelatin capsule:
Size No. 0.
Cap: sunset yellow dye E 110 - 0.04%; titanium dioxide E 171 - 2.0%; gelatin - up to 100%.
Frame: sunset yellow dye E 110 - 0.04%; titanium dioxide E 171 - 2.0%, quinoline yellow dye E 104 - 0.50%; gelatin - up to 100%.

Description
50 mg capsules:
Capsule: hard gelatin, size No. 3; Cap: opaque, yellow;
Body: opaque, white.
100 mg capsules: Capsule contents: fine-grained granular powder mixture of white color.
Capsule: hard gelatin, size No.0; Cap: opaque, orange; Body: opaque, yellow.

Pharmacotherapeutic group:

diuretic potassium-sparing agent.

ATX code C03DA01

Pharmacological properties
Pharmacodynamics
Spironolactone is a potassium-sparing diuretic, a specific antagonist of long-acting aldosterone (mineralocorticosteroid hormone of the adrenal cortex). In the distal parts of the nephron, spironolactone prevents the retention of sodium and water by aldosterone and suppresses the potassium-removing effect of aldosterone, reduces the synthesis of permeases in the aldosterone-dependent area of ​​the collecting ducts and distal tubules. By binding to aldosterone receptors, it increases the excretion of sodium, chlorine and water ions in the urine, reduces the excretion of potassium and urea ions, and reduces the acidity of urine.
Increased diuresis due to the presence of a diuretic effect, which is unstable; The diuretic effect appears on days 2-5 of treatment.
Pharmacokinetics
Suction and distribution
When taken orally, it is quickly and completely absorbed from the gastrointestinal tract.
Binds to plasma proteins by approximately 98% (canrenone - 90%). The maximum concentration (Cmax) of canrenone in the blood plasma is achieved 2-4 hours after administration.
After daily intake of 100 mg of spironolactone for 15 days, Cmax reaches 80 ng/ml, the time to reach Cmax after the next morning dose is 2-6 hours. Volume of distribution is 0.05 l/kg.
Metabolism
Spironolactone is converted into active metabolites: a metabolite containing sulfur (80%) and partly canrenone (20%). Spironolactone penetrates poorly into organs and tissues, while itself and its metabolites penetrate the placental barrier, and canrenone passes into breast milk.
breeding
Excreted by the kidneys; 50% - in the form of metabolites, 10% - unchanged and partially through the intestines. The half-life (T 1/2) of spironolactone is 13-24 hours, of active metabolites - up to 15 hours. The elimination of canrenone (mainly by the kidneys) is two-phase, T 1/2 in the first phase is 2-3 hours, in the second -12-96 hours .
Pharmacokinetics in selected patient groups
In liver cirrhosis and heart failure, the half-life increases without signs of accumulation, the likelihood of which is higher in chronic renal failure and hyperkalemia.

Indications for use
- Essential arterial hypertension (as part of combination therapy).
- Edema syndrome in chronic heart failure (can be used as monotherapy and in combination with standard therapy);
- Conditions in which secondary hyperaldosteronism may be detected, including cirrhosis of the liver accompanied by ascites and/or edema, nephrotic syndrome, as well as other conditions accompanied by edema.
- Hypokalemia/hypomagnesemia (as an adjuvant for its prevention during treatment with diuretics and when it is impossible to use other methods of correcting potassium levels).
- Primary hyperaldosteronism (Conn's syndrome) - for a short preoperative course of treatment.
- To establish the diagnosis of primary hyperaldosteronism.

Contraindications
- Hypersensitivity to any of the components of the drug;
- Addison's disease;
- Hyperkalemia;
- Hyponatremia;
- Severe renal failure (creatinine clearance less than 10 ml/min);
- Anuria;
- Pregnancy, breastfeeding period;
- Children under 3 years of age (solid dosage form);
- Lactase deficiency, lactose intolerance, glucose-galactose malabsorption.

Carefully
- Hypercalcemia, metabolic acidosis, atrioventricular blockade (hyperkalemia contributes to its strengthening);
- Diabetes mellitus (with confirmed or suspected chronic renal failure);
- Diabetic nephropathy;
- Surgical interventions during anesthesia;
- Taking medications that cause gynecomastia;
- Local and general anesthesia;
- Elderly age;
- Menstrual irregularities, enlarged mammary glands;
- Liver failure, liver cirrhosis.

Use during pregnancy and lactation
During pregnancy:
The drug is contraindicated during pregnancy.
During lactation
The drug is contraindicated during lactation. Breastfeeding should be discontinued if spironolactone cannot be discontinued.

Dosage and administration
Inside.
For essential hypertension
The daily dose for adults is usually 50-100 mg once and can be increased to 200 mg, while increasing the dose should be gradual, 1 time in 2 weeks.
To achieve an adequate response to therapy, the drug must be taken for at least 2 weeks. If necessary, adjust the dose.
For idiopathic hyperaldosteronism 100-400 mg/day.
With severe hyperaldosteronism and hypokalemia 300 mg / day (maximum 400 mg) for 2-3 doses, with improvement in the condition, the dose is gradually reduced to 25 mg / day in another dosage form.
Hypokalemia/hypomagnesemia
In case of hypokalemia and / or hypomagnesemia caused by diuretic therapy, the drug is prescribed at a dose of 25-100 mg / day, once or in several doses. The maximum daily dose is 400 mg if oral potassium supplements or other methods of replenishing the deficiency are ineffective.
Diagnosis and treatment of primary hyperaldosteronism
As a diagnostic tool for short diagnostic test: for 4 days, 400 mg/day, divided into several doses per day. If the potassium content in the blood increases while taking the drug and decreases after its discontinuation, the presence of primary hyperaldosteronism can be assumed.
For a long-term diagnostic test: at the same dose for 3-4 weeks. When correction of hypokalemia and arterial hypertension is achieved, the presence of primary hyperaldosteronism can be assumed.
Short course of preoperative therapy for primary hyperaldosteronism
After the diagnosis of hyperaldosteronism has been established using more accurate diagnostic methods, Veroshpiron should be taken at a dose of 100-400 mg/day, divided into 1-4 doses per day during the entire period of preparation for surgery. If surgery is not indicated, then Veroshpiron is used for long-term maintenance therapy, using the lowest effective dose, which is selected individually for each patient.
Edema due to nephrotic syndrome
The daily dose for adults is usually 100-200 mg/day. No effect of spironolactone on the underlying pathological process has been identified, and therefore the use of this drug is recommended only in cases where other types of therapy are ineffective.
For edema syndrome against the background of chronic heart failure daily, for 5 days, 100-200 mg/day in 2-3 doses, in combination with a loop or thiazide diuretic, depending on the effect, the daily dose is reduced to 25 mg. The maintenance dose is selected individually. Maximum dose 200 mg/day.
Edema due to liver cirrhosis
If the ratio of sodium and potassium ions (Na + /K +) in the urine exceeds 1.0, then the daily dose for adults is usually 100 mg. If the ratio is less than 1.0, then the daily dose for adults is usually 200-400 mg. The maintenance dose is selected individually.
Edema in children
The initial dose in children over 3 years of age is 1-3.3 mg/kg body weight or 30-90 mg/m2/day in 1-4 doses. After 5 days, the dose is adjusted and, if necessary, increased by 3 times compared to the original.

Side effect
From the gastrointestinal tract: nausea, vomiting, diarrhea, ulceration and bleeding from the gastrointestinal tract, gastritis, intestinal colic, abdominal pain, constipation.
From the liver: liver dysfunction.
From the central nervous system: ataxia, lethargy, dizziness, headache, drowsiness, lethargy, confusion, muscle spasm.
From the hematopoietic system: agranulocytosis, thrombocytopenia, megaloblastosis.
From the laboratory parameters: hyperuricemia, hypercreatininemia, increased urea concentration, impaired water and electrolyte balance (hyperkalemia, hyponatremia) and acid-base balance (metabolic hyperchloremic acidosis or alkalosis).
From the endocrine system: deepening of the voice, in men - gynecomastia (the likelihood of development depends on the dose, duration of treatment and is usually reversible); decreased potency and erection; in women - menstrual irregularities; dysmenorrhea; amenorrhea; metrorrhagia during menopause; hirsutism; pain in the mammary glands; breast carcinoma (no connection with the drug has been established).
When using the drug Veroshpiron, gynecomastia may develop. The likelihood of gynecomastia depends on both the dose of the drug and the duration of therapy. In this case, gynecomastia is usually reversible, and after discontinuation of the drug Veroshpiron disappears, and only in rare cases the mammary gland remains somewhat enlarged.
Allergic reactions: urticaria, rarely maculopapular and erythematous rash, drug fever, pruritus, eosinophilia, Steven-Johnson syndrome, toxic epidermal necrolysis.
From the skin: alopecia, hypertrichosis.
From the urinary system: acute renal failure.
From the musculoskeletal system: cramps of the calf muscles.

Overdose
Symptoms: nausea, vomiting, dizziness, diarrhea, skin rash, hyperkalemia (paresthesia, muscle weakness, arrhythmias), hyponatremia (dry oral mucosa, thirst, drowsiness), hypercalcemia, dehydration, increased urea concentration.
Treatment: gastric lavage, symptomatic treatment of dehydration and arterial hypotension. In case of hyperkalemia, it is necessary to normalize the water-electrolyte balance with the help of potassium-removing diuretics, rapid parenteral administration of a dextrose solution (5-20% solutions) with insulin at the rate of 0.25-0.5 units per 1 g of dextrose; can be re-entered if necessary. In severe cases, hemodialysis is performed.

Interaction with other drugs
Reduces the effect of anticoagulants, indirect anticoagulants (heparin, coumarin derivatives, idandione) and the toxicity of cardiac glycosides (since normalization of potassium content in the blood prevents the development of toxicity).
Enhances the metabolism of phenazole (antipyrine).
Reduces the sensitivity of blood vessels to norepinephrine (requires caution during anesthesia), increases the half-life of digoxin - digoxin intoxication is possible.
Strengthens the toxic effect of lithium due to a decrease in its clearance.
Possibly enhances the effect of non-depolarizing muscle relaxants (for example, tubocurarine).
Accelerates the metabolism and excretion of carbenoxolone.
Carbenoxolone promotes sodium retention by spironolactone.
Glucocorticosteroid drugs and diuretics (benzothiazine derivatives, furosemide, ethacrynic acid) enhance and accelerate the diuretic and natriuretic effects.
Enhances the effect of diuretic and antihypertensive drugs. Nonsteroidal anti-inflammatory drugs reduce the diuretic and natriuretic effects, increasing the risk of developing hyperkalemia.
Alcohol (ethanol), barbiturates, and narcotic substances increase orthostatic hypotension.
Glucocorticosteroid drugs enhance the diuretic and natriuretic effect in cases of hypoalbuminemia and/or hyponatremia.
The risk of developing hyperkalemia increases when taken with potassium preparations, potassium supplements and potassium-sparing diuretics, angiotensin-converting enzyme inhibitors (acidosis), angiotensin II antagonists, aldosterone blockers, indomethacin, cyclosporine.
Salicylates and indomethacin reduce the diuretic effect.
Ammonium chloride and cholestyramine contribute to the development of hyperkalemic metabolic acidosis.
Fludrocortisone causes a paradoxical increase in tubular secretion of potassium.
Reduces the effect of mitotane.
Enhances the effect of triptorelin, buserelin, gonadorelin.

special instructions
A temporary increase in serum urea nitrogen is possible, especially with reduced renal function and hyperkalemia. Reversible hyperchloremic metabolic acidosis is possible.
In case of kidney and liver diseases, as well as in old age, regular monitoring of serum electrolytes and kidney function is necessary.
The drug makes it difficult to detect digoxin, cortisol and adrenaline in the blood. Despite the lack of a direct effect on carbohydrate metabolism, the presence of diabetes mellitus, especially with diabetic nephropathy, requires special caution due to the possibility of developing hyperkalemia.
When treating with non-steroidal anti-inflammatory drugs, renal function and blood electrolyte concentrations should be monitored. You should avoid eating foods rich in potassium.
During treatment, alcohol consumption is contraindicated.

The effect of the drug on the ability to drive a vehicle and operate machinery, the operation of which is associated with an increased risk of injury
In the initial period of treatment, driving vehicles and engaging in activities that require increased concentration and speed of psychomotor reactions are prohibited. The duration of restrictions is set individually.

Release form
Capsules of 50 and 100 mg.
10 capsules in an AL/PVC blister. 3 blisters in a cardboard box with attached instructions for use.

Storage conditions
At a temperature not exceeding 30 °C.
Keep out of the reach of children!

Best before date
5 years
Do not use after the date indicated on the package.

Vacation conditions
Dispensed by prescription.

Manufacturer
JSC "Gedeon Richter"
1103 Budapest, st. Demrei 19-21, Hungary

Consumer complaints should be sent to:
Moscow Representative Office of JSC Gedeon Richter
119049 Moscow, 4th Dobryninsky lane, building 8.

The international nonproprietary name of the drug is Spironolactone. Veroshparon is a potassium-sparing diuretic. It acts as a competitive antagonist of aldosterone (adrenal hormone). Veroshpiron is a non-standard diuretic. Unlike conventional diuretics, it does not remove potassium, but promotes its accumulation in the body.

Composition and release form

Release form of Veroshpiron:

Available in tablets (25 mg spironolactone) and capsules (50 mg or 100 mg spironolactone). In a blister with tablets, their quantity is 20 pieces. , one blister in a cardboard box.

• 1 tablet contains 25 mg of spironolactone.
• 1 capsule contains 50 mg or 100 mg of spironolactone.

In a blister pack with capsules, their quantity is 10 pcs. , 3 packs in a cardboard box. The tablets are white or almost white, flat, round, marked VEROSPIRON on one side. The capsules have white powdery contents inside. Capsules 50 mg yellow. Capsules 100 mg orange color.

The instructions for use indicate that Veroshpiron should be stored at a temperature of no more than 30 °C. The shelf life of the drug is 5 years. Dispensed by prescription.

pharmachologic effect

Although the drug has a long history of medical use and has proven itself positively, it should only be taken as prescribed by a medical specialist. Too much potassium is just as dangerous for the body as too little potassium. The mechanism of action of Veroshpiron is based on the competition of its active substance with aldosterone. When binding to receptors sensitive to aldosterone, fluid is removed from the body. At the same time, sodium, chlorine, potassium and urea are not excreted after taking the drug and can accumulate in the body. These processes cause a decrease in urine acidity.

The most pronounced effect of taking the drug can be observed 7 hours after oral administration. The total duration of action is at least 24 hours. The diuretic effect determines the hypotensive effect of Veroshpiron. A pronounced diuretic effect manifests itself on days 2–5 of taking the drug.

When taken orally, the medicine is completely and quickly absorbed from the gastrointestinal tract, binds to blood plasma proteins (approximately 98%), then reaches the liver, where it breaks down into metabolic products (metabolites). In the liver it is converted into active metabolites:

• metabolite containing sulfur (80%),
• metabolite containing canrenone (20%).

The drug penetrates poorly into tissues and organs, but it itself and its metabolites penetrate the placental barrier, and canrenone passes into breast milk. The half-life of veroshpiron is 13–24 hours, and its active metabolites - up to 15 hours. It is excreted mainly by the kidneys: 50% - in the form of metabolites, 10% - unchanged and partially. The remaining amount is excreted from the gastrointestinal tract with feces.

If the patient has cirrhosis of the liver or heart failure, the half-life after taking the drug becomes longer. In this case, there are no signs of cumulation. Its likelihood increases for patients with chronic renal failure and hyperkalemia.

Indications for use of Veroshpiron

• high blood pressure and stagnation of fluid in the body, which provoke the development of heart disease, kidney disease and lung problems;
• lack of potassium and magnesium in the body, combined with other indications for taking diuretics;
• the need to identify primary hyperaldosteronism;
• increased levels of the adrenal hormone aldosterone in the blood;
• preoperative course of treatment of primary hyperaldosteronism.

What does Veroshpiron help with, what diseases?

• essential hypertension;
• edema syndrome in chronic heart failure;
• conditions accompanied by edema (liver cirrhosis, nephrotic syndrome and others);
• hypokalemia/hypomagnesemia;

Contraindications

• hypersensitivity to any of the components of the drug;
• severe renal failure, anuria;
• hyperkalemia, hyponatremia;
• Addison's disease;
• children under 3 years of age;
• pregnancy and breastfeeding period.

Take Veroshpiron with caution:

• metabolic acidosis;
• diabetic nephropathy;
• liver failure;
• menstrual irregularities;
• hypercalcemia;
• elderly age;
• children under 18 years of age;
• taking drugs that cause gynecomastia;
• AV block;
• diabetes;
• surgical interventions, local and general anesthesia;
• cirrhosis of the liver.

Side effects

From the side of the central nervous system: impaired coordination, lethargy, headache, drowsiness, lethargy, dizziness, confusion, muscle spasms.

From the skin: alopecia, hypertrichosis after taking the drug.

From the liver: dysfunction.

From the gastrointestinal tract: Gastrointestinal disorders in the form of constipation and diarrhea, nausea, vomiting, colic, pain, ulceration and bleeding from the gastrointestinal tract, gastritis. From the endocrine system: in men - gynecomastia, decreased potency and erection; in women - menstrual irregularities, metrorrhagia during menopause, pain in the mammary glands;

From the musculoskeletal side: cramps of the calf muscles.

From the hematopoietic system: agranulocytosis, thrombocytopenia, megaloblastosis.

From the urinary system: renal failure;

allergic reactions: urticaria, rarely - rash, fever, itching.

Instructions for use

Veroshpiron is taken orally at the same time as a meal or immediately after it. Regarding the dosage and duration of use, you must follow the instructions received from your doctor or the instructions for the drug.

Usually the drug is prescribed to be taken 2 times a day. If the drug is prescribed once a day, it is better to take it in the morning; if 2 times a day, then in the morning and at lunch. Use of the drug in the evening is not recommended, as it may lead to too frequent visits to the toilet.

Your doctor may change the dosage, frequency, and duration of use based on your body's response to the drug. The official instructions for use provide the following regimens for taking medication for various diseases and conditions.

Veroshpiron for essential hypertension

The standard dose prescribed for adults per day is usually 50-100 mg. An increase to 200 mg is possible, but this process must be carried out gradually. To obtain pronounced and lasting results from therapy, the drug must be taken for at least 2 weeks. It is possible to adjust the dose if necessary.

Veroshpiron for idiopathic hyperaldosteronism

The instructions for use note that the daily dose of the drug is from 100 to 400 mg. For severe hyperaldosteronism and hypokalemia: the daily dose is 300 mg (possibly increased to 400 mg), divided into 2-3 doses. As the patient's condition improves, the dose is gradually reduced to 25 mg per day.

Veroshpiron for hypokalemia/hypomagnesemia

If these diseases are caused by diuretic therapy, then the drug is prescribed at a dose of 25-100 mg of medication per day. The dose can be taken once or divided into several doses. In cases where oral potassium supplements or other methods of replenishing it are ineffective, it is possible to increase the maximum daily dose of the drug to 400 mg.

Veroshpiron for primary hyperaldosteronism

For a short diagnostic test: 400 mg daily is taken for 4 days. This amount is distributed over several doses per day. If potassium levels in the blood increase while taking the drug and decrease after discontinuation, the presence of primary hyperaldosteronism can be assumed.

For a long-term diagnostic test: 400 mg per day is taken for 3-4 weeks. A short course of preoperative therapy with Veroshpiron for primary hyperaldosteronism. After diagnosing hyperaldosteronism, the medicine should be taken in a daily dosage of 100-400 mg. This dose is used during the entire period of preparation for surgery, taken 1-4 times a day. When surgery is not indicated, the drug is taken as a means of long-term maintenance therapy. In this case, the doctor prescribes the smallest effective dose; it is selected for each patient individually.

Veroshpiron for edema due to nephrotic syndrome

The daily dose is 100-200 mg. Taking the drug is recommended only in cases of ineffectiveness of other types of therapy (since the effect of spironolactone on the underlying pathological process has not been proven). If edema is observed against the background of chronic heart failure, then the drug is prescribed for 5 days, 100-200 mg, divided into 2-3 doses. Veroshpiron is prescribed together with a loop or thiazide diuretic. The daily dose as prescribed by a doctor can be reduced to 25 mg.

If edema is observed against the background of liver cirrhosis, then the daily dose for adults is 100 mg (with the ratio of sodium and potassium ions (Na+/K+) in the urine exceeding 1.0). In other cases, the daily dose of the drug for adults is prescribed at 200-400 mg. For children, the initial dose is 1-3.3 mg per 1 kg of body weight. Reception is carried out 1-4 times.

After 5 days, the dose is adjusted, possibly increasing 3 times compared to the original. If the next dose of the drug is missed, but no more than 4 hours have passed, you should immediately take the missed dose of the drug. Otherwise, take Veroshpiron in the usual dosage at your next dose.

During therapy with Veroshpiron, you should avoid consuming excessive amounts of salt and potassium-rich foods (bananas, apricots, coconuts, peaches, dates, oranges, tomatoes, grapefruits, prunes). You cannot drink alcoholic beverages. At the beginning of treatment with the drug, you must stop driving vehicles and other activities that require quick reactions and increased attention. The duration of restrictions while taking the drug will depend on the patient’s health condition.

Veroshpiron for weight loss

Veroshpiron, as a diuretic drug, can get rid of several extra pounds by removing fluid from the body. Regimen for taking weight loss medications are published on the Internet and in some periodicals. Despite the fact that the product can have such an effect, taking it for weight loss is strictly prohibited. Loss of body weight does not occur as a result of loss of adipose tissue, and the fluid removed from the body is easily replaced in the coming days. Therefore, the effect is short-lived. It may be accompanied by a number of serious side effects. Taking medication, as well as other diuretics for weight loss, is absolutely unjustified and even dangerous!

Veroshpiron for children

Despite the fact that children under 3 years of age are indicated in the instructions as contraindications, in practice Veroshpiron is sometimes prescribed to younger children (even infants). But treatment of children of this age must necessarily be carried out in a hospital or at least under strict medical supervision. In pediatric practice, this drug can be taken as a diuretic for various diseases. The duration of use and dosage are determined only by the doctor; parents must carefully and thoroughly follow the doctor's instructions.

It is allowed to grind the tablet into powder and mix it with milk or baby food. In some cases, especially in infants, vomiting occurs after use. If half an hour has not passed after taking the medication Veroshpiron, the child should be given another dose of the drug. If more than half an hour has passed, then there is no need to give the drug additionally.

An overdose of the drug in children, especially young children, is very dangerous. It is accompanied by drowsiness, weakness, and possibly heart rhythm disturbances or seizures. Signs of dehydration are detected, vomiting or diarrhea is possible. In these cases, you should urgently stop taking the drug and call a doctor or an ambulance.

During pregnancy and lactation

Veroshpiron should not be taken during pregnancy and lactation. If this drug is prescribed to nursing mothers according to indications, then breastfeeding should be discontinued, since spironolactone can pass into milk and negatively affect the child’s body.

Overdose

Symptoms of an overdose of Veroshpiron include: nausea, vomiting, decreased blood pressure, diarrhea, dizziness, hyperkalemia, hyponatremia, hypercalcemia, dehydration, rash, increased urea concentration. Overdose therapy should be aimed at eliminating symptoms. It consists of gastric lavage, treatment of dehydration and hypotension. In case of severe overdose symptoms, hemodialysis is performed after taking the drug.

Interaction with other drugs

Veroshpiron can interact with many medications, so when prescribing it, you should inform your doctor about taking any medications, vitamins and dietary supplements.

Domestic and foreign analogues

There are many drugs that are analogues (synonyms) of Veroshpiron, that is, drugs that contain the same active component spironolactone.

Analogues of Veroshpiron made in Russia:

• Verospilactone
• Vero-Spironolactone
• Spironol
• Spironol
• Spironolactone

Veroshpiron analogues of foreign production:

• Aldactone (UK);
• Spirix (Denmark);
• Spironaxane (UK);
• Urakton (Italy).

Price in pharmacies

The price of Veroshpiron in different pharmacies may vary significantly. This is due to the use of cheaper components and the pricing policy of the pharmacy chain.

Read the official information about the drug Veroshpiron, the instructions for use of which include general information and a treatment regimen. The text is provided for informational purposes only and cannot serve as a substitute for medical advice.

INN: spironolactone. Contains 25 mg for tablets, 50 or 100 mg for capsules.

Additional substances in tablets: talc, silicon dioxide, lactose monohydrate, magnesium stearate, corn starch.

Additional substances in capsules: sodium lauryl sulfate, lactose monohydrate, magnesium stearate, corn starch.

The cap and body of the capsule also contain gelatin, dyes and titanium dioxide.

Release form

The drug is available in the form of capsules and tablets.

pharmachologic effect

Competitive aldosterone antagonist , potassium-sparing diuretic.

Pharmacodynamics and pharmacokinetics

Main substance – spironaloctone . In the distal parts of the nephron, it prevents the retention of water and sodium by aldosterone, reduces the potassium excretion effect of aldosterone, reduces permease synthesis . The maximum effect of taking the drug is observed 7 hours after taking the capsule, last for 24 hours. The decrease in blood pressure is achieved by a diuretic effect, it manifests itself after 2-5 weeks of administration. The active substance becomes active metabolites. The medicine is excreted by the kidneys.

Indications for use of Veroshpiron

What is the medicine for? Let's look at why Veroshpiron is prescribed.

Tablets and capsules are used as part of combination therapy for essential hypertension . Indications for the use of Veroshpiron are also: edematous syndrome in CHF, nephrotic syndrome, ascites, cirrhosis of the liver. The drug is also used as an auxiliary substance in the prevention hypomagnesemia/hypokalemia during treatment with diuretics. The medicine is successfully used for Conn's syndrome during the preoperative short course of treatment, as well as in order to establish a diagnosis " Primary hyperaldosteronism ».

Contraindications

Contraindications for Veroshpiron are: hypersensitivity to the components of the drug, hyperkalemia, hyponatremia, severe renal failure (CC less than 10 ml / min), and lactation. With extreme caution, the drug is prescribed for metabolic, hypercalcemia, AV blockade, diabetes mellitus, diabetic nephropathy, menstrual irregularities, general and local anesthesia, liver and kidney diseases, as well as in the elderly.

Side effects

Gastrointestinal tract: diarrhea, nausea, vomiting, , intestinal colic, liver dysfunction.

central nervous system: lethargy, ataxia, headaches, dizziness, lethargy, drowsiness, muscle spasm, confusion, calf muscle cramps.

Side effects from hematopoietic organs: thrombocytopenia, megaloblastosis.

Metabolism: hypercreatininemia, hyperuricemia, hyperkalemia, increased urea levels, hyponatremia, hyperchloremic metabolic alkalosis and acidosis.

Endocrine system: in men, gynecomastia and decreased potency may develop. In women, dysmenorrhea, terorrhagia, and breast carcinoma are possible.

Allergic reaction: pruritus, drug fever, urticaria, erythematous, maculopapular rash.

Dermatological reaction: hypertrichosis, .

urinary system: acute renal failure.

Instructions for use of Veroshpiron (Method and dosage)

The instructions for use for Veroshpiron capsules and tablets are the same. It all depends on the amount of active substance taken.

Essential hypertension: Adults: 50-100 mg once. The dose can be gradually increased to 200 mg, the amount of the drug is increased once every 2 weeks.

Idiopathic hyperaldosteronism: 100-400 mg per day.

Severe hyperaldosteronism, hypokalemia: per day 300 mg in 2-3 doses. Gradually, the dose of the drug is reduced to 25 mg per day.

Hypomagnesemia, nipokalemia, provoked by the action of diuretics: 25-100 mg per day, once or in several doses.

Diagnosis and treatment of primary hyperaldosteronism: 400 mg per day for 4 days. The daily dose of the medicine is divided into several doses.

How to take for swelling?

Edema in nephrotic syndrome: adults 100-200 mg per day. Veroshpiron is used only if other treatment methods have been ineffective.

Edema syndrome in CHF: 100-200 mg per day (several doses) for 5 days in combination with thiazide and loop diuretics. The daily dose can be reduced to 25 mg.

Edema in cirrhosis: if the Na+/K+ ratio in the urine is above 1.0, then 100 mg is prescribed. If less than 1.0, then the daily dose is 200-400 mg.

Edema in children: initially 1-3.3 mg per 1 kg of body weight, or 30-90 mg/m2 per day for 1-4 doses. After 5 days, the dose is adjusted.

How long can I take it?

The usual course is 20 days, followed by a break of at least six months. The longest possible use is for a couple of months. Long-term use can lead to acute renal failure.

Should I take it before or after meals?

Overdose

Terms of sale

Requires a prescription.

Storage conditions

Keep out of reach of children at temperatures up to 30 degrees Celsius.

Best before date

No more than 5 years.

special instructions

Veroshpiron is prescribed in gynecology to reduce the rate in women with PCOS (). The drug can cause bleeding and disrupt the menstrual cycle. Veroshpiron is often recommended to be taken together with in order to normalize the menstrual cycle and reduce hirsutism.

Recipe in Latin:

Rp.: Verospironi 0.025
D.t. d. N 20 in tabul.
S.

There is no article on the drug in Wikipedia.

During pregnancy

The drug is contraindicated in pregnancy and breastfeeding.

Analogues of Veroshpiron

Level 4 ATX code matches:

Analogues of the drug are:,. The price of analogues is lower.

Reviews about Veroshpiron

Reviews about Veroshpiron on the forums testify in favor of this drug. The medicine is effective, but it is advised to use it in moderation and as prescribed by a doctor, since the drug has side effects and contraindications.

Diuretic tablets fully cope with their assigned function, and also effectively help against edema. In gynecology, the drug is successfully used for skya.

Veroshpiron also helps for weight loss, as it has a diuretic property.

Those who have used the medication claim that it does not help with hirsutism.

Veroshpiron price, where to buy

The price of Veroshpiron in tablets is 75 rubles for 20 pieces.

Capsules can be bought for 160 rubles for 30 pieces of 50 mg and for 250 rubles for 30 pieces of 100 mg.

How much does the drug cost in Ukraine? The price of Veroshpiron in Kharkov is on average 100 UAH for 20 tablets of 25 mg.

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ZdravCity

Veroshpiron tab. 25 mg No. 20JSC "Gedeon Richter-RUS"

Veroshpiron caps. 50mg No. 30Gedeon Richter/Gedeon Richter-RUS ZAO

Veroshpiron caps. 100mg No. 30Gedeon Richter / JSC "GEDEON RICHTER-RUS"

Pharmacy Dialog

Veroshpilakton (Veroshpiron) (caps. 100 mg No. 30)

Veroshpiron capsules 100 mg No. 30

Veroshpiron is a drug that, according to the manufacturer’s instructions, is not officially approved for use in children under three years of age. But in some cases, pediatric neurologists prescribe it to children under one year of age, more often this happens in a hospital setting.

Why does a baby need veroshpiron?

There is a period of a child’s life that is especially dangerous in relation to various effects on the central nervous system. It begins from the twenty-eighth week of pregnancy, ends a week after the birth of the child and is called the perinatal period. Brain lesions that arose during this period are called perinatal: perinatal lesions of the nervous system (PPNS) or perinatal encephalopathy.

Very often, perinatal lesions of the nervous system are accompanied by high intracranial pressure, when a lot of fluid collects inside the brain. This usually occurs due to changes in the vessels of the brain, stagnation of blood in them and sweating of the liquid part of the blood out. At the same time, the child becomes very restless, screams, and has trouble latching on to the breast. In order to reduce intracranial pressure, diuretics are prescribed, including veroshpiron.

How does veroshpiron act on infants - is it really necessary to take it?

Veroshpiron is a diuretic (diuretic) that suppresses the action of the adrenal hormone aldosterone. Aldosterone retains water and sodium in the body and removes potassium, which is vital for muscle function, especially the heart muscle. Under the influence of veroshpiron, water and sodium are removed from the body, and potassium remains in the body, therefore veroshpiron is called a potassium-sparing diuretic.

But too much potassium is just as harmful to the body as too little potassium. Therefore, veroshpiron, which has a mild diuretic effect, is prescribed only when there is a lack of potassium in the body. In infants, it can be prescribed, for example, in cases where potassium deficiency has developed after taking conventional diuretics, for example, after Diacarb.

Veroshpiron should under no circumstances be taken uncontrolled, so it is more often prescribed to infants in a hospital setting.

Side effects of veroshpiron - how dangerous is it for babies?

Veroshpiron has many side effects:

While taking veroshpiron, the baby should not be given medications that contain potassium (panangin, asparkam), as well as other potassium-sparing diuretics. In addition, laboratory monitoring of potassium levels in the blood, kidney and liver function is necessary.

Veroshpiron overdose

An overdose of veroshpiron for a baby is very dangerous. It is expressed in an increase in all side effects. In an infant lethargy, weakness, drowsiness increase, convulsive muscle twitching may appear, and the heart rhythm is disturbed. Dehydration causes the skin to become dry, there is no saliva in the mouth, and there may be vomiting and diarrhea.

Treatment consists of immediately stopping the administration of veroshpiron and gastric lavage. To restore water and electrolyte metabolism, the child is given saline solutions with sodium, glucose and insulin.

In what cases is veroshpiron not prescribed to infants?

You can not prescribe veroshpiron for diseases of the kidneys and liver, which are accompanied by a violation of their function. You can not prescribe it even if the child for some reason already has a violation of the water-salt balance - a decrease in the amount of sodium in the blood and an increase in potassium and calcium. In addition, veroshpiron should not be prescribed for metabolic disorders, which are accompanied by an increase in the total acidity of the body (acidosis).

Veroshpiron is a drug that can be prescribed to a baby only by a doctor and preferably in a hospital under laboratory control.

How to give veroshpiron to infants?

Veroshpiron is prescribed for infants who have heart failure. It promotes the removal of fluid from the body, thereby reducing the load on the baby's heart. Veroshpiron is a type of diuretic that belongs to potassium-sparing drugs - unlike many diuretics, they do not lower the level of potassium in the blood.

How to give veroshpiron to a child?

It is usually recommended to give veroshpiron twice a day, morning and evening. Ideally, 10-12 hours should pass between doses. Try to give veroshpiron at the same time, then it will become a habit and the likelihood that you will forget to give your baby the medicine will decrease.

The leaflet contains information about the dosage, but the doctor should tell you how much veroshpiron should be taken for your child. It is extremely important to follow the instructions you receive from your doctor exactly.

If the doctor prescribed veroshpiron in the form of tablets, they should be ground into powder and given to the child along with milk or baby food. Liquid veroshpiron should be given to the child using a special measuring spoon.

"Veroshpiron" is a popular diuretic, often prescribed by adults for high blood pressure or edema. Let's try to figure out whether it is possible to treat babies with such a drug and when it is used in childhood.

Release form

"Veroshpiron" is produced in two forms:

• Pills. They have a flat round shape, almost white color, a characteristic smell and have the inscription VEROSPIRON on one of the sides. One package contains 20 tablets.
• Capsules. They are made from gelatin and have a powdery white substance inside. The color of the capsules indicates the dosage of the drug (with a smaller dose - white, with a larger one - yellow-orange), and one pack contains 30 of them.

Compound

The main ingredient of Veroshpiron is spironolactone. Such a substance in one tablet is represented by a dosage of 25 mg, and capsules are produced with a content of spironolactone at a dose of 50 or 100 mg.

In both forms of the drug, manufacturers included lactose, cornstarch and magnesium stearate. In addition, the tablets contain colloidal silicon dioxide and talc, and the capsules contain sodium lauryl sulfate, gelatin and coloring components.

Operating principle

The main effect of "Veroshpiron" is diuretic. It does not appear immediately, but from the second day of treatment, resulting in a decrease in pressure. At the same time, the drug counteracts the adrenal hormone aldosterone, so that the body does not lose a lot of potassium and magnesium in the urine. Once in the kidney cells, the drug does not allow aldosterone to retain water, chlorine and sodium, but blocks the excessive excretion of urea and potassium, due to which the acidity of the urine decreases.

Indications

Treatment with "Veroshpiron" is prescribed:

• For swelling.
• With high blood pressure.
• With reduced potassium levels.
• With hyperaldosteronism.

At what age is it allowed to take it?

"Veroshpiron" is not recommended for use in children under 3 years of age. However, the doctor can prescribe such a medicine at an earlier age (infants and even premature babies), if there are indications for this. A child under three years of age must be supervised by a specialist.

Contraindications

The medication is not prescribed to children with:

• Severe renal failure.
• Hypersensitivity to spironolactone or another component of the drug.
• Anuria.
• Lack of lactase.
• Low sodium levels in the blood or high amounts of potassium.
• Problems with the absorption of glucose or galactose.
• Addison's disease.

If a young patient has been diagnosed with diabetes mellitus, AV block, hypercalcemia or liver failure, Veroshpiron should be used very carefully. Increased attention also requires the use of medication after surgery.

Side effects

During the reception of "Veroshpiron" the appearance of:

• Loose stools, abdominal pain, vomiting and other negative symptoms from the digestive tract.
• Dizziness, lethargy, drowsiness, headaches.
• Changes in blood tests: decreased granulocyte levels, increased levels of potassium, urea, creatinine, decreased platelet count.
• Deepening of the voice.
• Allergies in the form of urticaria.
• Hair loss.
• Kidney disorders.
• Muscle spasms.

Instructions for use and dosage

The drug should be swallowed and washed down with water. It is not recommended to bite or chew the capsules, so they are prescribed only to those children who can easily swallow such a drug. Children under 6 years of age are often prescribed tablets because they can be crushed into powder and mixed with water or milk if necessary.

The best time to take it is morning or afternoon. Tablets should be taken with meals or immediately after meals. Treatment of edema in children begins with a dosage of 1 to 3 mg of the active ingredient per kilogram of weight. After five days, the required dosage is adjusted, taking into account the therapeutic effect of the drug. If the medication is prescribed for other pathologies, the dose and frequency of administration must be determined individually.

Overdose

If a child is given the wrong dose, causing them to receive more spironolactone, this will result in dizziness, nausea, low blood pressure, dry mouth, muscle weakness, skin rashes, and other symptoms of overdose. For treatment, the stomach should be rinsed and the patient should be given medications that normalize electrolyte and fluid levels. If the condition is severe, resort to hemodialysis.