Betadine instructions for use in treatment. "Betadine", solution: instructions for use, indications and reviews. Indications for use of the drug

Instructions for use:

pharmachologic effect

Betadine is a topical antiseptic that is a combination of iodine and its binder polyvinylpyrrolidone.

The complex of these substances is called povidone-iodine, and the international nonproprietary name is also Betadine. This drug has bactericidal, antiseptic, antiviral, antiprotozoal (affects protozoa), antifungal and disinfectant effects. Iodine, which is part of Betadine, upon contact with the skin or mucous membranes, is released from the complex with polyvinylpyrrolidone and damages the cells of pathogenic microorganisms. The drug begins to act within 15-30 seconds after application, and within 1 minute the complete death of microorganisms occurs. The effectiveness of Betadine is indicated by the color of iodine, which begins to weaken after contact with microbes, fungi, protozoa and viruses.

Long-term local use of Betadine causes significant absorption of iodine, especially when treating large wound surfaces, however, after the last use of the drug, within 1-2 weeks the concentration of iodine in the blood returns to its original value. Clinical studies and Betadine reviews indicate that this drug lasts longer than conventional alcohol solutions of iodine, and also does not have an irritating effect.

Indications for use

Betadine is available in the form of an aerosol, a concentrate for the preparation of a solution, an ointment, a suppository and a solution, each of the forms has its own indications for use.

Betadine ointment is prescribed in the following cases:

• prevention of infection in minor abrasions, cuts, burns, minor surgical interventions;
• treatment of infected bedsores or trophic ulcers;
• treatment of fungal, bacterial and mixed skin infections.

According to the instructions for Betadine, the drug in the form of a solution is used for:

• antiseptic treatment of burn wounds;
• antiseptic treatment of mucous membranes or skin before procedures and operations;
• hygienic or surgical disinfection of hands;
• bladder catheterization, punctures, injections, biopsies;
• contamination of mucous membranes or skin with infected material as first aid.

It is advisable to use Betadine suppositories for:

• acute and chronic vaginal infections: bacterial vaginosis, genital herpes, trichomonas infection and others;
• as part of combination therapy for trichomoniasis;
• processing associated with diagnostic and obstetric procedures, as well as transvaginal surgical operations;
• fungal infections of the vagina, which were provoked by therapy with antibacterial and steroid medications.

Instructions for use of Betadine

Betadine ointment is used topically. Before applying the drug, the wound surface should be cleaned and dried. Betadine ointment is applied in a thin layer, after which an aseptic dressing can be applied. Infectious wounds are treated 1-2 times a day for two weeks. For prophylaxis against contamination, Betadine ointment is usually used once every three days until the desired effect is achieved.

Betadine solution can be used undiluted or diluted with water:

• for the treatment of small abrasions, wounds, burns, a concentrated 10% solution is used;
• pustular skin diseases and acne, according to the instructions for Betadine, are wiped with a swab with a concentrated 10% or 5% (1 part solution and 2 parts water) solution;
• disinfection of healthy skin areas before various medical procedures (blood drawing, puncture, infusion, biopsy, transfusion) is carried out using a concentrated solution for 1-2 minutes;
• to disinfect mucous membranes and skin before surgical interventions, Betadine solution is used twice for two minutes; wiping the patient before surgery is carried out with a sponge soaked in a 0.1% - 0.05% solution, which is obtained by diluting one part of a 10% solution with 100 and 200 parts of water, respectively;
• the consequences of invasive manipulations are treated with a 10% or 5% solution;
• for aseptic wound management and treatment of complications, use a 5% solution or without dilution;
• treatment of burns can be carried out with a 10%, 5% or 1% (1 part Betadine and 10 parts water) solution depending on the condition of the burn surface;
• for washing the cavity of the joints and serous cavities - 1% - 0.1% solution;
• in ophthalmology and transplantology – 1% - 5% solution;
• during the surgical treatment of cysts of parenchymal organs, during minor gynecological operations, a concentrated solution of Betadine is used to treat the birth canal;
• to treat the skin of newborns, use a 0.1% solution, for the umbilical wound - a 10% solution, and to prevent conjunctivitis in infants - 2-3 drops in the eyes of a 2.5% - 5% solution;
• for bacterial or fungal dermatitis - 1% solution;
• papillomas and herpetic rashes on the skin are treated with a concentrated solution of Betadine.

Betadine suppositories should be slightly wetted before use. It is recommended to use 1 suppository before bed, which must be inserted deep into the vagina. Betadine suppositories can be used during menstruation. The course of treatment is usually 1 week, however, in case of incomplete effectiveness of Betadine suppositories, the course of use can be extended. Also, as prescribed by the doctor, the single dose can be increased to two suppositories. Reviews of Betadine include recommendations regarding the use of sanitary pads during treatment with this drug.

Antiseptics - halogens and halogen-containing ones.

Composition of Betadine

The active substance is povidone-iodine.

Manufacturers

Egis Pharmaceutical Works SA (Hungary), Egis Pharmaceutical Plant (Hungary)

pharmachologic effect

Antiseptic, disinfectant.

It has a wide spectrum of antimicrobial action (gram-positive and gram-negative bacteria - with the exception of M/ tuberculosis, fungi, viruses, protozoa).

It has a longer action than inorganic iodine solution.

Suppositories are made on a water-soluble basis and do not have an irritating effect.

When applied topically, there is virtually no absorption of iodine from the skin, mucous membrane or wounds.

Side effects of Betadine

When used on a large wound surface and mucous membranes, systemic reabsorption of iodine may occur, which may affect thyroid function tests and also lead to the development of neutropenia.

In some cases, with hypersensitivity to the drug, local manifestations of allergic reactions to iodine (hyperemia, burning, itching, swelling, pain) may occur, requiring discontinuation of the drug.

Long-term use (more than 7-10 days) can cause the phenomenon of iodism (a “metallic” taste in the mouth, increased salivation, swelling of the eyes or larynx, etc.), if this occurs, you should stop using the drug and consult a doctor.

Indications for use

Solution for external use 10%.

Treatment and prevention of wound infections in surgery, traumatology, combustiology, dentistry.

Treatment of bacterial, fungal and viral skin infections, prevention of superinfection in dermatological practice.

Treatment of bedsores, trophic ulcers, diabetic foot.

Disinfection of the skin and mucous membranes of patients in preparation for surgical interventions, invasive studies (punctures, biopsies, injections, etc.) Disinfection of the skin around catheters, drainages, probes.

Disinfection of the oral cavity during dental operations.

Disinfection of the birth canal during “minor” gynecological operations (artificial termination of pregnancy, insertion of an intrauterine device, coagulation of erosion or polyp, etc.).

Foaming solution 7.5% for external use. "Disinfectant bathing" for complete or partial treatment of patients before surgery.

Disinfection of the skin of the hands of surgical personnel.

Hygienic treatment of patients.

Hygienic treatment of hands when in contact with infected patients.

Processing of non-metallic instruments and patient care items.

Concentrate for preparing a solution for topical use.

Inflammatory processes in the mouth and throat.

Condition after surgical interventions in the mouth and throat.

Eliminating bad breath.

Bacterial and fungal skin infections, burns, trophic ulcers, bedsores, infectious dermatitis, abrasions, wounds.

Vaginal suppositories.

Treatment of vaginitis (mixed, nonspecific), candidiasis, trichomoniasis, genital herpes; preoperative preparation.

Contraindications Betadine

Hypersensitivity, thyroid adenoma, hyperthyroidism, Dühring's dermatitis herpetiformis, chronic renal failure, simultaneous use of radioactive iodine, pregnancy, lactation, children under 8 years of age.

Directions for use and dosage

1 suppository 1-2 times a day; Duration of treatment is 7-14 days.

Overdose

No information available.

Interaction

Incompatible with other disinfectants and antiseptics, especially those containing alkalis, enzymes and mercury.

Activity decreases in an acidic environment.

special instructions

Solution 10%, foaming solution 7.5%.

It is necessary to ensure that no excess solution remains under the patient.

Should not be heated before use.

Concentrate 8.5% for preparing a solution for topical use.

It has a deodorizing effect - it destroys bad breath that occurs after eating food, alcoholic beverages, and tobacco.

Solutions 10, 7.5%; concentrate 8.5%; ointment 10%.

The presence of pus and blood can reduce the antimicrobial effect of the drug.

A colored film is formed at the site of application, which persists until the entire amount of active iodine is released, which means that the effect of the drug ceases.

Should not be used for bites from insects, domestic or wild animals.

All dosage forms.

Coloring on leather and fabrics is easily washed off with water.

Avoid contact of the drug with the eyes.

Antiseptic for external and local use

Active substance

Release form, composition and packaging

◊ Solution for local and external use dark brown in color, with the smell of iodine.

Excipients: glycerol, nonoxynol 9, anhydrous citric acid, sodium hydrogen phosphate (disodium hydrogen phosphate), sodium hydroxide, purified water.

30 ml - polyethylene bottles (1) - cardboard packs.
120 ml - polyethylene bottles (1) - cardboard packs.
1000 ml - polyethylene bottles.

pharmachologic effect

Antiseptic and disinfectant preparation. Released from the complex with polyvinylpyrrolidone upon contact with the skin and mucous membranes, iodine forms iodamines with bacterial cell proteins, coagulates them and causes the death of microorganisms. It has a rapid bactericidal effect on gram-positive and gram-negative bacteria (with the exception of Mycobacterium tuberculosis). Effective against fungi, viruses, protozoa.

Pharmacokinetics

When applied topically, there is almost no absorption of iodine.

Indications

• treatment and prevention of wound infections in surgery, traumatology, combustiology, dentistry;
• treatment of bacterial, fungal and viral skin infections, prevention of superinfection in dermatological practice;
• treatment of bedsores, diabetic foot;
• disinfection of the skin and mucous membranes of patients in preparation for surgical interventions, invasive studies (including punctures, biopsies, injections);
• disinfection of the skin around drainages, catheters, probes;
• disinfection of the oral cavity during dental operations;
• disinfection of the birth canal during “minor” gynecological operations (including artificial abortion, insertion of an IUD, coagulation of erosion and polyp).

Contraindications

Dosage

To treat the skin and mucous membranes, a solution of Betadine is used undiluted for lubrication, rinsing, or as a wet compress.

For use in drainage systems, a 10% solution is diluted 10 to 100 times. The solution is prepared immediately before use; diluted solutions are not stored.

Side effects

With frequent use over a large area of ​​the wound surface and mucous membranes, systemic reabsorption of iodine may occur, which may affect tests of the functional activity of the thyroid gland.

Hypersensitivity reactions to the drug, possible manifestations of an allergic reaction (hyperemia, burning, itching, swelling, pain), which requires discontinuation of the drug.

Overdose

Data on overdose of the drug Betadine are not provided.

Drug interactions

Betadine is incompatible with other antiseptics, especially those containing alkalis, enzymes and mercury.

In the presence of blood, the bactericidal effect may decrease, but by increasing the concentration of the solution, the bactericidal activity may increase.

special instructions

In case of dysfunction of the thyroid gland, the use of the drug is possible only under the strict supervision of a doctor.

The use of the drug in newborns is possible only in case of emergency, after testing the function of the thyroid gland.

Caution should be exercised when used regularly on damaged skin in patients with chronic renal failure.

Care must be taken to ensure that no excess solution remains under the patient. Do not heat the solution before use.

A colored film is formed at the site of application, which persists until the entire amount of active iodine is released, which means that the effect of the drug ceases.

Coloring on leather and fabrics is easily washed off with water.

Compound

Description of the dosage form

Ointment: homogeneous, brown in color, with a faint odor of iodine.

pharmachologic effect

pharmachologic effect- antiseptic.

Pharmacodynamics

Antiseptic and disinfectant. Released from the complex with PVP, upon contact with the skin and mucous membranes, iodine forms iodamines with bacterial proteins, coagulates them and causes the death of microorganisms. Has a rapid bactericidal effect on gram-positive and gram-negative bacteria (except M. tuberculosis). Effective against fungi, viruses, protozoa.

Pharmacokinetics

When applied topically, there is almost no absorption of iodine.

Indications of the drug Betadine ®

bacterial and fungal skin infections;

trophic ulcers;

bedsores;

infectious dermatitis;

Contraindications

hypersensitivity to iodine and other components of the drug;

dysfunction of the thyroid gland (hyperthyroidism) (see “Special instructions”);

thyroid adenoma;

Dühring's dermatitis herpetiformis;

simultaneous use of radioactive iodine;

premature and newborn babies (see “Special Instructions”).

Carefully: pregnancy and lactation, chronic renal failure.

Side effects

With frequent use over a large area of ​​the wound surface and mucous membranes, systemic absorption of iodine may occur, which may affect tests of the functional activity of the thyroid gland.

Hypersensitivity reactions to the drug - an allergic reaction (hyperemia, burning, itching, swelling, pain) is possible, which requires discontinuation of the drug.

Interaction

Incompatible with other disinfectants and antiseptics, especially those containing alkalis, enzymes and mercury.

In the presence of blood, the bactericidal effect may decrease, but with increasing concentrations of the drug, the bactericidal activity may be increased.

Directions for use and doses

Externally. The ointment is applied in a thin layer to the affected surface 2-3 times a day; can be used under an occlusive dressing.

special instructions

In case of dysfunction of the thyroid gland, the use of the drug is possible only under the strict supervision of a doctor.

Antiseptic drug with a broad spectrum of antimicrobial action against bacteria, some viruses, fungi and protozoa. Upon contact with the skin and mucous membrane, iodine is gradually released and has a bactericidal effect.
Iodine reacts with oxidizable groups of amino acids that are part of the enzymes and structural proteins of microorganisms, inactivating or destroying these proteins. The action develops in the first 15-30 s, and the death of most microorganisms in vitro happens in less than 1 minute. In this case, the iodine becomes discolored, and therefore a change in the intensity of the brown color is an indicator of its effectiveness.
When a complex is formed with the polyvinylpyrrolidone polymer, iodine largely loses the local irritating effect characteristic of alcohol solutions of iodine, and therefore is well tolerated when applied to the skin, mucous membranes and affected surfaces.
Due to the mechanism of action, resistance to the drug, including secondary resistance, does not develop with long-term use.
Prolonged application of the drug to large wound surfaces or severe burns, as well as to mucous membranes, can lead to the absorption of a significant amount of iodine. As a rule, due to long-term use of the drug, the concentration of iodine in the blood quickly increases. The concentration returns to the initial level 7-14 days after the last use of the drug.
The absorption and renal excretion of povidone-iodine depends on its molecular weight, and since it ranges from 35,000-50,000, retention of the substance in the body is possible. It is excreted from the body mainly by the kidneys. The volume of distribution is approximately 38% of body weight, the half-life after vaginal use is about 2 days. Typically, the level of total iodine in blood plasma is approximately 3.8-6.0 μg/dL, and inorganic iodine - 0.01-0.5 μg/dL.

Indications for use of the drug Betadine

Solution:

• disinfection of hands and antiseptic treatment of the mucous membrane, for example, before surgery, gynecological and obstetric procedures, bladder catheterization, biopsy, injections, punctures, blood collection, as well as first aid in case of accidental contamination of the skin with infected material;
• antiseptic treatment of wounds and burns;
• hygienic and surgical disinfection of hands.

Ointment:

• prevention of infections in minor cuts and abrasions, minor burns and minor surgical procedures;
• treatment of fungal and bacterial skin infections, as well as infected bedsores and trophic ulcers.

Suppositories:

• acute and chronic vaginal infections (colpitis): mixed infections; nonspecific infections (bacterial vaginosis, Cardnella vaginalis, trichomonas infection, genital herpes);
• fungal infections (including those caused by Candida albicans) due to treatment with antibiotics and steroid drugs;
• trichomoniasis (if necessary, carry out combined systemic treatment);
• preoperative and postoperative treatment for transvaginal surgical interventions, as well as for obstetric and diagnostic procedures.

Use of the drug Betadine

Solution
The drug is intended for external use in diluted and undiluted form. The drug should not be diluted with hot water. Only short-term heating to body temperature is permissible.
The undiluted solution is used to treat hands and skin before surgical operations, catheterization of the bladder, injections, punctures, etc.
Solutions can be used 2-3 times a day.
Hygienic hand disinfection: 2 times 3 ml of undiluted solution - each dose of 3 ml is left on the skin for 30 s.
Surgical hand disinfection: 2 times 5 ml of undiluted solution - each dose of 5 ml is left on the skin for 5 minutes.
To disinfect the skin, the undiluted solution is left after use until it dries.
According to the above indications, the solution can be used after dilution with tap water. During surgical operations, as well as during antiseptic treatment of wounds and burns, isotonic sodium chloride solution or Ringer's solution should be used to dilute the drug.
The following dilutions are recommended:

The solution should be diluted immediately before use.

Ointment
The drug is for local use.
To treat infection: apply 1-2 times a day. The duration of treatment is no more than 14 days.
To prevent infection: apply 1-2 times a week as long as necessary. The affected skin surface should be cleaned and dried, and a thin layer of ointment should be applied. A bandage can be applied to the skin treated in this way.
Suppositories
The suppository is removed from the shell and, after moistening, inserted deep into the vagina.
During the treatment period, the use of sanitary pads is recommended.
Dosage: One vaginal suppository is inserted deep into the vagina in the evening before bed. The drug should be used daily (including during menstruation).
In case of insufficient effectiveness, the course of treatment can be continued, and the dose can be increased to 2 vaginal suppositories daily. The duration of treatment depends on the results of therapy, usually it is 7 days.

Contraindications to the use of the drug Betadine

Hypersensitivity to iodine or other components of the drug, hyperthyroidism, adenoma or dysfunction of the thyroid gland (nodular colloid goiter, endemic goiter and Hashimoto's thyroiditis), Dühring's dermatitis herpetiformis, condition before and after treatment or scintigraphy using radioactive iodine, renal failure, pregnancy and breastfeeding, age up to 1 year.

Side effects of the drug Betadine

Allergic skin reactions - itching, hyperemia, rash (contact dermatitis with the formation of psoriasis-like elements). In some cases, generalized acute reactions with a decrease in blood pressure and/or suffocation (anaphylactic reactions) are possible. In some cases, iodine-induced hyperthyroidism has been observed in predisposed individuals.
Application of povidone-iodine to large wounds or severe burns can cause adverse effects, such as changes in serum electrolyte levels (hypernatremia) and osmolarity, metabolic acidosis, renal dysfunction, and even acute renal failure.

Special instructions for the use of Betadine

The dark brown color of Betadine indicates the effectiveness of the solution; a decrease in color saturation is a sign of a decrease in the antimicrobial activity of the drug. Under the influence of light or a temperature of 40 ° C, the solution decomposes. The antimicrobial effect of Betadine solution is manifested at its pH from 2 to 7.
The use of povidone iodine may reduce the uptake of iodine by the thyroid gland, which may affect the results of some tests (thyroid scintigraphy, determination of protein-bound iodine, diagnostic procedures using radioactive iodine). When planning these procedures in the use of povidone-iodine, it is necessary to take a break of at least 1-4 weeks.
The oxidizing effects of Povidone-iodine can cause corrosion of metals, while plastic and synthetic materials are generally not sensitive to Povidone-iodine. In some cases, a change in color is possible, which is usually restored.
Povidone-iodine is easily removed from textiles and other materials with warm water and soap. Stains that are difficult to remove should be treated with ammonia or sodium thiosulfate solution.
During treatment with the drug, breastfeeding should be stopped.
The solution is not intended for oral administration.
During preoperative disinfection of the skin, it is necessary to ensure that no residues of the solution remain under the patient (due to the possibility of skin irritation).
Since the development of hyperthyroidism cannot be excluded, long-term (14 days) use of Povidone-iodine or its use in significant quantities over large surfaces (10% of body surface) in patients (especially elderly) with latent thyroid dysfunction is permissible only after careful comparison of the expected benefits and possible risk. These patients require monitoring for early signs of hyperthyroidism and proper evaluation of thyroid function, even after discontinuation of the drug (for a period of up to 3 months).
Long-term use of the drug can cause irritation and sometimes severe skin reactions. If signs of irritation or hypersensitivity appear, application of the drug should be discontinued.
Significant amounts of iodine can cause hyperthyroidism in patients with thyroid dysfunction. Therefore, they are limited in the use of ointment or solution according to the time and area of ​​the skin surface being treated.
If symptoms of hyperthyroidism occur during treatment, thyroid function should be monitored.
High doses of iodine should be avoided in infants and young children because their skin is highly permeable and they are more likely to be sensitive to iodine, increasing the risk of developing hyperthyroidism. Povidone-iodine should be used in low doses in these patients. If necessary, thyroid function should be monitored.
Particular caution should be taken when using the drug regularly in patients with previously diagnosed renal failure. Regular use of the ointment should be avoided in patients receiving lithium preparations.
Regular use of povidone-iodine during pregnancy and lactation is possible only according to absolute indications and in low doses, since absorbed iodine penetrates the placental barrier and can pass into breast milk.
The level of povidone-iodine in milk is higher than its level in blood serum. Use of this drug may cause transient hyperthyroidism in the fetus and newborn. In these cases, testing of the child's thyroid function may be necessary.
Avoid accidental exposure of the drug to the mouth or gastrointestinal tract, especially in children.

Drug interactions Betadine

The simultaneous use of povidone-iodine and hydrogen peroxide, as well as enzyme preparations containing silver and tauloridine, for the treatment of wounds or antiseptic drugs, leads to a mutual decrease in effectiveness, and therefore their combined use is not recommended.
Povidone iodine should not be used with mercury preparations due to the risk of formation of alkaline mercury iodide.
The drug can react with proteins and unsaturated organic complexes, so the effect of povidone-iodine can be compensated by increasing its dose. Long-term use of the drug should be avoided, especially on large surfaces, in patients using lithium preparations.

Overdose of the drug Betadine

Acute iodine intoxication is characterized by the following symptoms: metallic taste in the mouth, increased salivation, heartburn, pain in the mouth or throat; irritation and swelling of the eyes; skin reactions; gastrointestinal disorders; renal dysfunction, anuria; circulatory failure; laryngeal edema with secondary asphyxia, pulmonary edema, metabolic acidosis, hypernatremia.
Long-term treatment of burn wounds with significant amounts of povidone-iodine can provoke an imbalance of electrolyte balance or serum osmolarity with impaired renal function or metabolic acidosis.
Treatment: Carry out supportive and symptomatic therapy under the control of electrolyte balance, renal and thyroid function.
In case of intoxication caused by ingestion of the drug, immediate administration of foods containing starch or protein (for example, starch solution in water or milk), gastric lavage with 5% sodium thiosulfate solution or, if necessary, intravenous administration of 10 ml 10 % sodium thiosulfate solution at 3-hour intervals. Monitoring of thyroid function is indicated for early detection of iodine-induced hyperthyroidism.

Storage conditions for the drug Betadine

Solution: in a place protected from light at a temperature of 5-15 °C.
Ointment: in a dry place at temperatures up to 25 ° C.
Suppositories: in a dry place at a temperature of 5-15 ° C.

List of pharmacies where you can buy Betadine:

• Saint Petersburg