home Calculators Acc long international name. Effervescent tablets ACC Long. How the medicine works

Acc long international name. Effervescent tablets ACC Long. How the medicine works

Instructions for medical use of the drug

Description of pharmacological action

Indications for use

Common to all dosage forms.

Respiratory diseases accompanied by the formation of viscous, difficult to separate sputum:
acute and chronic bronchitis;
obstructive bronchitis;
laryngotracheitis;
pneumonia;
bronchiectasis;
bronchial asthma;
bronchiolitis;
cystic fibrosis;
acute and chronic sinusitis;
inflammation of the middle ear (otitis media).

For syrup granules (orange) additionally: chronic obstructive pulmonary disease (COPD).

Release form

tablets for the preparation of an effervescent drink 600 mg; polypropylene tube 10, cardboard pack 1;
tablets for the preparation of an effervescent drink 600 mg; polypropylene tube 6, cardboard pack 1;
tablets for the preparation of an effervescent drink 600 mg; polypropylene tube 20, cardboard pack 1;

Pharmacodynamics

The presence of sulfhydryl groups in the structure of acetylcysteine promotes the rupture of disulfide bonds of acidic mucopolysaccharides of sputum, which leads to a decrease in the viscosity of mucus. The drug remains active in the presence of purulent sputum.

With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.

Use during pregnancy

To ensure safety, due to insufficient data, the use of the drug during pregnancy and lactation is possible only if the expected benefit to the mother outweighs the potential risk to the fetus or infant.

Contraindications for use

Hypersensitivity to acetylcysteine or other components of the drug;
pregnancy;
lactation;
children's age (up to 14 years).

With caution - peptic ulcer of the stomach and duodenum in the acute stage; hemoptysis, pulmonary hemorrhage, esophageal varices, bronchial asthma, adrenal diseases, liver and/or kidney failure.

Side effects

In rare cases, headache, inflammation of the oral mucosa (stomatitis) and tinnitus may occur. Extremely rarely - diarrhea, vomiting, heartburn and nausea, decreased blood pressure, increased heart rate (tachycardia). In isolated cases, allergic reactions such as bronchospasm (mainly in patients with bronchial hyperreactivity), skin rash, itching and urticaria are observed. In addition, there are isolated reports of bleeding due to the presence of hypersensitivity reactions.

If side effects develop, you should stop taking the drug and consult a doctor.

Directions for use and doses

Inside. In the absence of other prescriptions, it is recommended to adhere to the following dosages.

Effervescent tablets should be dissolved in one glass of water and taken after meals. The tablets should be taken immediately after dissolution; in exceptional cases, the ready-to-use solution can be left for 2 hours.

Additional fluid intake enhances the mucolytic effect of the drug.

For short-term colds, the duration of use is 5–7 days. For long-term illnesses, the duration of therapy is determined by the attending physician. In case of chronic bronchitis, the drug should be taken for a longer period of time to achieve a preventive effect against infections.

Instructions for patients with diabetes:
1 effervescent tablet corresponds to 0.01 XE.

Overdose

In case of an erroneous or intentional overdose, phenomena such as diarrhea, vomiting, stomach pain, heartburn and nausea are observed. To date, no severe or life-threatening side effects have been observed.

Interactions with other drugs

With the simultaneous use of acetylcysteine and antitussives, mucus stagnation may occur due to suppression of the cough reflex. Therefore, such combinations should be selected with caution.

The simultaneous use of acetylcysteine and nitroglycerin can lead to an increase in the vasodilatory effect of the latter.

Pharmaceutically incompatible with antibiotics (penicillins, cephalosporins, erythromycin, tetracycline and amphotericin B) and proteolytic enzymes.

Upon contact with metals and rubber, sulfides with a characteristic odor are formed.

Reduces the absorption of penicillins, cephalosporins, tetracycline (they should be taken no earlier than 2 hours after ingestion of acetylcysteine).

Special instructions for use

For patients with bronchial asthma and obstructive bronchitis, acetylcysteine should be prescribed with caution under systematic monitoring of bronchial patency.

When treating patients with diabetes, it is necessary to take into account that granules for preparing syrup contain sorbitol, and granules for preparing oral solution and effervescent tablets contain sucrose.

When working with the drug, you must use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 30 °C. Close the tube tightly after taking the tablet.

Best before date

ATX classification:

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Some facts about the product:

Instructions for use

Price in online pharmacy website: from 385

Description of the drug

ACC Long is a drug that is part of the group of mucolytic medications. It is based on acetylcysteine. The compound is a derivative of the amino acid cysteine. The substance is characterized by mucolytic quality, accelerates the removal of sputum. This becomes possible due to its influence on the rheological characteristics of sputum secretions.

Release form, composition and packaging

The medication is produced in the form of flat-cylindrical tablets. The product has a blackberry scent. A slight smell of sulfur cannot be ruled out. One tablet of the product contains 1g of the main chemical substance. To enhance its effect, other materials are added to the product - mannitol, flavoring, sodium bicarbonate compound, ascorbic acid. The medication is placed in special tubes made of aluminum and plastic. ACC Long price – from 127 to 564 rubles.

pharmachologic effect

The mechanism of influence of the drug on the human body is due to the ability to damage the disulfide bonds of units that consist of mucopolysaccharides. As a result, depolymerization of sputum components occurs. Sputum secretions become less viscous. The substance shows good results in the presence of sputum with purulent formations. Experts note the antioxidant qualities of the drug. They are associated with the ability of some groups of the product to combine with oxidative radicals, eliminating them. The material takes part in the synthesis of the compound glutathione, which is an important element of the antioxidant structure of the body. The substance is able to enhance the protective reaction of cells during the oxidation process by free radicals. After all, the degree of complexity of the inflammatory process depends on this. There is information about the prophylactic use of the drug. It can significantly reduce the risks and reduce the severity of exacerbations in patients with prolonged bronchitis and cystic fibrosis. Absorption of the drug is high. Bioavailability when administered orally is 10%. This is due to the passage of the substance through the liver system. Cmax in plasma blood substance can be detected after 60-180 minutes. The product combines with plasma proteins of the blood substance by 50%. There is no information on the ability of the material to penetrate the BBB and enter breast milk. The product undergoes a metabolic stage in the liver. The result is cysteine, which is an active metabolite. The substance is eliminated through the kidneys. At the exit, the drug turns into inactive metabolites.

ACC Long indications

The drug is prescribed for pathologies of the respiratory organs, in which viscous sputum secretions are formed - cystic fibrosis, pneumonia, bronchitis, occurring in acute and protracted forms, tracheitis, lung abscess and others. The medication is also effective for sinusitis and otitis media.

Contraindications

The product is prohibited for use in case of gastric and duodenal ulcers during exacerbation, coughing up blood, bleeding of the lungs, breastfeeding, children under 2 or 14 years of age, depending on the form of the medication. It is dangerous to prescribe if there is a lack of lactase, does not accept lactose, or the body is hypersensitive to some of the components of the product. You should take ACC Long with special care if you have a history of digestive ulcers, bronchial asthma, obstructive bronchitis, insufficient liver or kidney function, failure to take histamine, varicose veins, adrenal dysfunction, high blood pressure.

Dosage

The substance is taken orally after meals. The medication must be dissolved in a container with a volume of 250 mg. The product is drunk immediately after preparation. The effervescent solution in its finished form can be left for no more than two hours. An amount of the substance exceeding a single dosage may enhance the mucolytic effect. Adults and minors who are already 14 years old should be prescribed 2 tablets. up to 3 times a day. It is allowed to take 600 mg 1 time per day. Minors from 6 to 14 years old can use 1 tablet. ACC 100 3 times a day, or 1 tablet. ACC 200 2 times a day. The medication is prescribed to children from 2 to 6 years old. The dose is determined by a specialist.

How to take ACC Long in other cases

If a diagnosis of cystic fibrosis is established, minors over 6 years of age are prescribed the substance in quantities of 2 or 1 pc. - ACC100 and ACC 200, respectively, 3 times a day. If cold pathologies develop, the course of treatment is up to 7 days. If bronchitis or cystic fibrosis is chronic, the chemical should be used for a long time in order to prevent infection of the body.

Side effects

During therapy, acetylcysteine can cause accidental symptoms in the form of skin rash, shortness of breath, bronchospasm, exanthema, angioedema, tachycardia, decreased blood pressure, urticaria, toxic epidermal necrolysis. Negative reactions can also occur in the digestive system - diarrhea, nausea, dyspepsia, pain in the intestines. Fever may develop, a decrease in platelet adhesiveness, tinnitus, and bleeding may occur. If these or other symptoms occur, you should immediately see a doctor.

Overdose

There is evidence of taking ACC Long in a dosage that exceeds the norm. The patient had diarrhea, stomach pain, heartburn, nausea, and gag reflexes. If you accidentally take an overdose, you should immediately contact a specialist. Basically, symptomatic therapy methods are used to remove the drug from the body.

Drug interactions

When taking a mucolytic drug simultaneously with antitussive medications, stagnation of sputum secretions may occur. This occurs due to suppression of the cough reflex. If at the same time the substance is used with antimicrobial medications that are taken orally, the effectiveness of the latter decreases. Instructions for use of ACC Long indicate that such antibiotics are cephalosporins, penicillins, tetracyclines and others. To prevent such processes, you need to leave a gap of at least 2 hours between two doses. There is information about the simultaneous use of the drug with vasodilator compounds and nitroglycerin. This combination of materials causes a vasodilating effect. To avoid painful symptoms, a treatment regimen should be developed by a specialist after examining the body. Delivery of ACC Long in Moscow is free.

special instructions

The drug must be prescribed with special care in the development of asthma and bronchitis of the obstructive type. In this case, systematic monitoring of the patient’s condition, in particular, bronchial patency, should be carried out. According to doctors, after the administration of the drug, cases of the development of complex forms of allergenic response of the immune system, such as toxic-allergic disease or toxic epidermal necrolysis, are very rare. If negative signs appear in the form of a rash, itching on the body or pituitary surface, you should immediately consult a doctor. Glass containers are used to prepare chemicals. Any contact with metal, oxygen, rubber products and flammable materials is not allowed. It is not recommended to use the medication at night. The evening time is best - around 18.00. When disposing of unused material, you do not need to adhere to special disposal rules. There is no information about the negative impact of chemical substances on the ability to operate complex devices, cars, or participate in activities associated with increased concentration.

Pregnancy and lactation

There is no information about the potential threat of the medication during pregnancy. If a newborn is fed breast lactose, it is necessary to consider the option of transferring him to artificial nutrition during the course of treatment.

Use in childhood

Prescribing pharmaceutical products to children under 14 years of age is prohibited.

For impaired renal function

For patients with a disorder of the renal structure, the substance is prescribed after a detailed examination and determination of the severity of the pathology.

For liver dysfunction

In case of dysfunction of the hepatobiliary system, the administration of the chemical should be carried out as directed and under the supervision of a medical expert. Analogs of the drug are ACC 200, Fluimucil.

Storage conditions and periods

The chemical product must be stored in a place closed from public access. The packaging should not be exposed to sunlight. Storage temperature – up to 30°C. Saving time – no more than 3 years. You can buy ACC Long in the pharmacy chain at a price of 269 rubles.

Pharmacodynamics: mucolytic agent, thins sputum and facilitates its separation. The action is associated with the ability of free sulfhydryl groups of acetylcysteine to break intra- and intermolecular disulfide bonds of acidic mucopolysaccharides of sputum, which leads to depolymerization of mucoproteins and a decrease in sputum viscosity. In addition, it reduces induced hyperplasia of mucoid cells, enhances the production of surfactants by stimulating type II pneumocytes, and stimulates mucociliary activity, which leads to improved mucociliary clearance. Remains active against purulent sputum, mucopurulent and mucous sputum. Increases the secretion of less viscous sialomucins by goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates mucous cells of the bronchi, the secretion of which is lysed by fibrin. It has a similar effect on the secretions formed during inflammatory diseases of the ENT organs. It has an antioxidant effect due to the presence of an SH group that can neutralize electrophilic oxidative toxins. Acetylcysteine easily penetrates into the cell and is deacetylated to L-cysteine, from which intracellular glutathione is synthesized. Glutathione is a highly reactive tripeptide, a powerful antioxidant, cytoprotector that traps endogenous and exogenous free radicals and toxins. Acetylcysteine prevents exhaustion and helps increase the synthesis of intracellular glutathione, which is involved in the redox processes of cells, thus promoting the detoxification of harmful substances. This explains the effect of acetylcysteine as an antidote for paracetamol poisoning. Paracetamol exerts its cytotoxic effect through the progressive depletion of glutathione. The main role of acetylcysteine is to maintain proper levels of glutathione concentration, thereby providing protection to cells. Protects alpha 1-antitrypsin (elastase inhibitor) from the inactivating effects of HOCl, an oxidizing agent produced by myeloperoxidase of active phagocytes. It also has an anti-inflammatory effect (by suppressing the formation of free radicals and reactive oxygen-containing substances responsible for the development of inflammation in the lung tissue). Pharmacokinetics: ACC Long is well absorbed when taken orally. It is immediately deacetylated to cysteine in the liver. In the blood, a mobile equilibrium of free acetylcysteine and its metabolites (cysteine, cystine, diacetylcysteine) is observed, free and bound to plasma proteins. Due to the strong first-pass effect through the liver, the bioavailability of acetylcysteine is about 10%. Acetylcysteine is distributed both unchanged (20%) and in the form of active metabolites (80%), penetrates into the intercellular space, is distributed mainly in the liver, kidneys, lungs and bronchial secretions. The volume of distribution of acetylcysteine varies from 0.33 to 0.47 l/kg, the maximum concentration in plasma is reached 1-3 hours after oral administration and is 15 mmol/l, binding to plasma proteins is 50% 4 hours after administration and decreases to 20% after 12 hours. Penetrates through the placental barrier. After oral administration, acetylcysteine is quickly and extensively metabolized in the intestinal wall to form the pharmacologically active metabolite cysteine, as well as diacetylcysteine, cystine). It is excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine), a small part is excreted unchanged through the intestines. The half-life of the drug from blood plasma (T1/2) is approximately 1 hour; if liver function is impaired, the value increases to 8 hours.

Description of the dosage form

Round, flat-cylindrical tablets, white, beveled, scored on one side, with a blackberry flavor. There may be a faint sulfuric odor.

The reconstituted solution is colorless, transparent, with a blackberry odor; there may be a slight sulfuric odor.

Pharmacodynamics

It has an antioxidant effect based on the ability of its reactive sulfhydryl groups (SH groups) to bind to oxidative radicals and thus neutralize them.

In addition, acetylcysteine promotes the synthesis of glutathione, an important component of the antioxidant system and chemical detoxification of the body. The antioxidant effect of acetylcysteine increases the protection of cells from the damaging effects of free radical oxidation, which is characteristic of an intense inflammatory reaction.

With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations of bacterial etiology in patients with chronic bronchitis and cystic fibrosis.

Pharmacokinetics

Absorption is high. Rapidly metabolized in the liver to form a pharmacologically active metabolite - cysteine, as well as diacetylcysteine, cystine and mixed disulfides. Bioavailability when taken orally is 10% (due to the presence of a pronounced first-pass effect through the liver). Tmax in blood plasma is 1–3 hours. Communication with blood plasma proteins is 50%. Excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine). T1/2 is about 1 hour, impaired liver function leads to an extension of T1/2 to 8 hours. Penetrates the placental barrier. There are no data on the ability of acetylcysteine to penetrate the BBB and be excreted in breast milk.

ACC Long: Indications

Respiratory diseases accompanied by the formation of viscous, difficult to separate sputum:

acute and chronic bronchitis;

obstructive bronchitis;

tracheitis, laryngotracheitis;

pneumonia, lung abscess;

bronchiectasis;

bronchial asthma, chronic obstructive pulmonary disease;

bronchiolitis;

cystic fibrosis;

acute and chronic sinusitis;

inflammation of the middle ear (otitis media).

ACC Long: Contraindications

hypersensitivity to acetylcysteine or other components of the drug;

peptic ulcer of the stomach and duodenum in the acute stage;

hemoptysis, pulmonary hemorrhage;

lactase deficiency, lactose intolerance, glucose-galactose malabsorption;

pregnancy;

breastfeeding period;

children's age (up to 14 years).

Carefully: history of gastric and duodenal ulcers; varicose veins of the esophagus; bronchial asthma; obstructive bronchitis; adrenal gland diseases; liver and/or kidney failure; histamine intolerance (long-term use of the drug should be avoided, since acetylcysteine affects the metabolism of histamine and can lead to signs of intolerance, such as headache, vasomotor rhinitis, itching); arterial hypertension.

Use during pregnancy and breastfeeding

Data on the use of acetylcysteine during pregnancy and breastfeeding are limited, therefore the use of the drug during pregnancy is contraindicated.

If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.

Directions for use and doses

Inside, After meals, effervescent tablets should be dissolved in one glass of water and taken after meals. The tablets should be taken immediately after dissolution; in exceptional cases, the ready-to-use solution can be left for 2 hours. Additional fluid intake enhances the mucolytic effect of the drug.

For short-term colds, the duration of use is 5–7 days.

For chronic bronchitis and cystic fibrosis, the drug should be taken for a longer period of time to achieve a preventive effect.

In the absence of other prescriptions for mucolytic therapy, it is recommended to adhere to the following dosages: adults and children over 14 years of age - 1 tablet. effervescent 1 time per day (600 mg).

ACC Long: Side effects

Adverse effects are given in accordance with the WHO classification according to the frequency of their development as follows: very often (≥1/10), often (≥1/100,<1/10), нечасто (≥1/1000, <1/100), редко (≥1/10000, <1/1000) и очень редко (<1/10000); частота неизвестна (частоту возникновения явлений нельзя определить на основании имеющихся данных).

Allergic reactions: uncommon - skin itching, rash, exanthema, urticaria, angioedema, decreased blood pressure, tachycardia; very rarely - anaphylactic reactions up to anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).

From the respiratory system: rarely - shortness of breath, bronchospasm (mainly in patients with bronchial hyperreactivity in bronchial asthma).

From the senses: infrequently - tinnitus.

From the gastrointestinal tract: uncommon - stomatitis, abdominal pain, nausea, vomiting, diarrhea, dyspepsia.

Others: very rarely - headache, fever, isolated reports of bleeding due to the presence of a hypersensitivity reaction, decreased platelet aggregation.

Overdose

Symptoms: In case of an erroneous or intentional overdose, phenomena such as diarrhea, vomiting, stomach pain, heartburn and nausea are observed.

Treatment: symptomatic.

Interaction

With the simultaneous use of acetylcysteine and antitussives, sputum stagnation may occur due to suppression of the cough reflex.

When used simultaneously with oral antibiotics (including penicillins, tetracyclines, cephalosporins), they may interact with the thiol group of acetylcysteine, which can lead to a decrease in their antibacterial activity. Therefore, the interval between taking antibiotics and acetylcysteine should be at least 2 hours (except for cefixime and loracarbef).

Active substance

Acetylcysteine

Dosage form

soluble tablets

Manufacturer

Sandoz, Switzerland

Compound

1 effervescent tablet contains:
active ingredient: acetylcysteine 600 mg
Excipients:
anhydrous citric acid - 625.00 mg; sodium bicarbonate - 327.00 mg; sodium carbonate - 104.00 mg; mannitol - 72.80 mg; lactose - 70.00 mg; ascorbic acid - 75.00 mg; sodium cyclamate - 30.75 mg; sodium saccharinate dihydrate - 5.00 mg; sodium citrate dihydrate - 0.45 mg; blackberry flavor “B” - 40.00 mg.

Effervescent tablets 600 mg
Primary packaging
6, 10 or 20 effervescent tablets in a polypropylene tube.
Secondary packaging
1 tube in a cardboard box along with instructions for use.

pharmachologic effect

PHARMACODYNAMICS

Acetylcysteine is a derivative of the amino acid cysteine. It has a mucolytic effect, facilitates the discharge of sputum due to a direct effect on the rheological properties of sputum. The action is due to the ability to break the disulfide bonds of mucopolysaccharide chains and cause depolymerization of sputum mucoproteins, which leads to a decrease in sputum viscosity. The drug remains active in the presence of purulent sputum. It has an antioxidant effect based on the ability of its reactive sulfhydryl groups (SH groups) to bind to oxidative radicals and thus neutralize them. In addition, acetylcysteine promotes the synthesis of glutathione, an important component of the antioxidant system and chemical detoxification of the body. The antioxidant effect of acetylcysteine increases the protection of cells from the damaging effects of free radical oxidation, which is characteristic of an intense inflammatory reaction. With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations of bacterial etiology in patients with chronic bronchitis and cystic fibrosis.

PHARMACOKINETICS

Absorption is high. They are quickly metabolized in the liver to form a pharmacologically active metabolite - cysteine, as well as diacetylcysteine, cystine and mixed disulfides. Oral bioavailability is 10% (due to the presence of a pronounced “first pass” effect through the liver). The time to reach maximum concentration in blood plasma is 1-3 hours. Communication with blood plasma proteins is 50%. Excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine). The half-life (T1/2) is about 1 hour, impaired liver function leads to an extension of T1/2 to 8 hours. Penetrates the placental barrier. There are no data on the ability of acetylcysteine to penetrate the blood-brain barrier and be excreted in breast milk.

Indications

Respiratory diseases accompanied by the formation of viscous, difficult to separate sputum:
acute and chronic bronchitis, obstructive bronchitis;
tracheitis, laryngotracheitis;
pneumonia;
lung abscess;
bronchiectasis, bronchial asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis;
cystic fibrosis;
Acute and chronic sinusitis, inflammation of the middle ear (otitis media).

Contraindications

Hypersensitivity to acetylcysteine or other components of the drug;
peptic ulcer of the stomach and duodenum in the acute stage;
hemoptysis, pulmonary hemorrhage;
pregnancy;
lactation period;
children under 14 years of age (for this dosage form);
lactase deficiency, lactose intolerance, glucose-galactose malabsorption.
With caution - a history of gastric and duodenal ulcers, bronchial asthma, obstructive bronchitis, liver and/or renal failure, histamine intolerance (long-term use of the drug should be avoided, since acetylcysteine affects the metabolism of histamine and can lead to signs of intolerance , such as headache, vasomotor rhinitis, itching), varicose veins of the esophagus, diseases of the adrenal glands, arterial hypertension.

Side effects

According to the World Health Organization (WHO), undesirable effects are classified according to their frequency of development as follows: very often (≥ 1/10), often (≥1/100, Allergic reactions
uncommon: skin itching, rash, exanthema, urticaria; angioedema, decreased blood pressure, tachycardia;
very rare: anaphylactic reactions up to anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).
From the respiratory system
rarely: shortness of breath, bronchospasm (mainly in patients with bronchial hyperreactivity in bronchial asthma).
From the senses
uncommon: tinnitus. From the gastrointestinal tract
uncommon: stomatitis, abdominal pain, nausea, vomiting, diarrhea, dyspepsia.
Others
very rarely: headache, fever, isolated reports of bleeding due to a hypersensitivity reaction, decreased platelet aggregation.

Interaction

With the simultaneous use of acetylcysteine and antitussives, sputum stagnation may occur due to suppression of the cough reflex. When used simultaneously with oral antibiotics (penicillins, tetracyclines, cephalosporins, etc.), they may interact with the thiol group of acetylcysteine, which can lead to a decrease in their antibacterial activity. Therefore, the interval between taking antibiotics and acetylcysteine should be at least 2 hours (except for cefixime and loracarbef). Simultaneous use with vasodilating agents and nitroglycerin can lead to increased vasodilatory effects.

How to take, course of administration and dosage

Inside, after eating. Effervescent tablets should be dissolved in one glass of water. The tablets should be taken immediately after dissolution; in exceptional cases, the ready-to-use solution can be left for 2 hours. Additional fluid intake enhances the mucolytic effect of the drug. For short-term colds, the duration of use is 5-7 days. For chronic bronchitis and cystic fibrosis, the drug should be taken for a longer period of time to achieve a preventive effect.
In the absence of other prescriptions, it is recommended to adhere to the following dosages:
Mucolytic therapy:
Adults and children over 14 years of age: 1 effervescent tablet once a day (600 mg).

Overdose

Symptoms: In case of an erroneous or intentional overdose, phenomena such as diarrhea, vomiting, stomach pain, heartburn and nausea are observed. Treatment: symptomatic.

Special instructions

INDICATIONS FOR PATIENTS WITH DIABETES

1 effervescent tablet corresponds to 0.001 XE.

SPECIAL INSTRUCTIONS

When working with the drug, you must use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances. Cases of severe allergic reactions such as Stevens-Johnson syndrome and Lyell's syndrome have been very rarely reported with the use of acetylcysteine. If changes occur in the skin and mucous membranes, you should immediately consult a doctor and stop taking the drug.
In patients with bronchial asthma and obstructive bronchitis, acetylcysteine should be prescribed with caution under systemic monitoring of bronchial patency.
You should not take the drug immediately before bedtime (it is recommended to take the drug before 18.00).