home Calculators Nurofen - official instructions for use. Instructions for use Nurofen: composition, pharmacological properties of the drug, special instructions

Nurofen - official instructions for use. Instructions for use Nurofen: composition, pharmacological properties of the drug, special instructions

People face pain, inflammation, from infancy to old age. It is not always clear how to act in this situation - call a doctor or take a pill on your own? This drug helps to cope with the symptoms of the disease, you just need to study the instructions for use.

Composition of Nurofen

This drug belongs to the group of non-steroidal anti-inflammatory drugs with an affordable price. The composition of Nurofen depends on the form of release of the drug. The instructions for use describe the following composition of the tablet:

If we consider other forms of the Nurofen preparation, its instructions for use contain the following information: in the composition of suppositories - ibuprofen 60 mg, the rest is solid fat. The suspension has other components, the main one is ibuprofen - its amount is 5 ml per 100 mg of the composition. Additional substances:

How does Nurofen work?

The action of the drug is based on the suppression in the body of the main ingredient - ibuprofen - of active substances that contribute to the development of inflammatory processes, fever, pain. The drug is effective for 8 hours, then it is excreted from the body with feces, urine. With local use of the gel, a limited area is treated. The action of Nurofen contributes to:

decrease in temperature;
reduction of inflammation;
reduction of edema;
active anesthesia;
stimulating the development of immunity.

Nurofen - indications for use

Possessing a strong analgesic, anti-inflammatory property, the remedy is used to treat adults and children. Excellent reviews from doctors have indications of Nurofen in the event of:

How long does Nurofen take to work?

According to the instructions for use, the drug is absorbed by the intestines, enters the bloodstream. The fastest result is when using rectal suppositories. How long does it take for Nurofen to start working? The time depends on its form of release:

candles for children - 10 minutes;
suspension - a quarter of an hour;
preparations for adults - up to 30 minutes;
composition of express forte - a quarter of an hour.

Nurofen instructions

The drug has a strong therapeutic effect, so before use, you should read the instructions, learn about contraindications, side effects. The use of the drug in adults is incompatible with alcohol. According to the instructions, the use of tablets is recommended after meals, they should be washed down with water. According to the annotation to the drug, it has several forms of release:

The instruction of the drug Nurofen stipulates:

permissible doses of medication for children, adults;
impossibility of independent use for more than 3 days;
in the absence of results, side effects - contact the doctor;
during the reception, the symptoms are eliminated without treating the cause;
the use of the gel after 12 years;
negative impact on work with complex devices, transport management;
the inability to simultaneously take other non-steroidal anti-inflammatory drugs.

Instructions for use of the drug in the treatment of chronic diseases recommends:

periodically do a biochemical blood test;
if side effects occur, discontinue treatment;
with caution combine the drug with diuretics, painkillers;
if necessary, the use of steroid hormones should be discontinued within 2 days.

Nurofen children's syrup - instructions for use

The liquid form of the product has a pleasant taste; for convenience, there is a special measuring spoon in the package. If Nurofen syrup is prescribed, instructions for use for children prescribe its use, depending on age, three times a day, after meals. Shake the suspension before use. Single maximum dose, ml:

3 to 12 months - 2.5;
1-3 years - 5.0;
from 4 to 6 years - 7.5;
7-9 years old - 10.0;
from 10 to 12 and older - 15.0.

Nurofen suppositories for children

A very convenient form of medication for babies, especially when there are problems with taking the drug in a different form. Nurofen suppositories have a low price, have a quick effect, reducing the high temperature during a cold. Put them in the child's anus. The parent gently inserts the candle with his finger, pushing it to the depth to the middle of the second phalanx. So you can treat a maximum of three days. Recommend scheme:

from 3 to 9 months - a candle three times a day;
further (up to 2 years) - a suppository every 6 hours.

Nurofen tablets

If the drug is purchased in coated capsules or tablets, they do not need to be chewed during treatment: the drug is swallowed with a small amount of water. How to drink Nurofen in effervescent form? The drug must be taken in liquid form within 15 minutes. To obtain a solution, Nurofen tablets are placed in half a glass of water. For the treatment of pain and inflammation, it is possible to use an analogue - the drug Ibufen.

Nurofen-gel - instructions for use

The drug in this form is used for local effects on the diseased area. Nurofen-gel is available in tubes of 50 and 100 grams, has an affordable price. It can not be spread on open wounds, damaged areas of the skin, places near the eyes. It is recommended to use the drug four times a day. If after 2 weeks the condition does not improve, you need to stop the use, consult a doctor. Apply the gel as follows:

squeeze out up to 10 cm of the composition;
rub with massage movements until absorbed.

Dosage of Nurofen

The instruction stipulates how to take Nurofen for adults. The duration of use depends on the nature of the disease, the symptoms present. Adult tablets are approved for children weighing more than 20 kg. The usual scheme - three times a day - with strong manifestations can be increased to four. The maximum daily dosage for adults should not exceed 1200 mg. Doctors prescribe for one appointment with an interval of at least 6 hours:

to reduce muscle, dental, menstrual, traumatic pain - 200 mg;
in order to accelerate the effect - 400 mg.

If inflammation and pain accompany chronic diseases, long-term use of the drug is required. When rheumatoid arthritis occurs in a child, the daily dose is calculated at 30 mg per kilogram of body weight and divided into 4 doses. The drug is consumed three times a day. Dosage depends on the cause:

arthritis, osteoarthritis - 600 mg;
muscle and tendon injuries - 600 mg;
rheumatoid arthritis - 800 mg;
severe pain during menstruation - 400 mg.

Nurofen for children

The drug, having a low price, is considered among pediatricians an effective tool for combating the symptoms of infections. The instruction stipulates its use in conjunction with other drugs that affect the causes of the disease. Antipyretic for children is produced in the form of syrup and rectal suppositories. In addition, the drug helps in case of:

Nurofen with HB

When a mother needs Nurofen during breastfeeding (HB) of a child, the instructions for use limit its use. The drug enters the milk, can cause an undesirable reaction in the baby. If acute inflammation occurs, the main symptoms can be removed in two days. At this time of taking Nurofen with HB it is necessary:

refuse to feed the child;
switch to mixtures;
express milk so that it is not lost;
choose a safe drug with a doctor.

Nurofen during pregnancy

With extreme caution, you need to approach the use of the drug while waiting for the baby. The use of Nurofen during pregnancy should be agreed with the gynecologist. The appointment depends on the timing:

The first two trimesters - only when a threatening situation arises for a woman, taking into account the risk to the child. At these stages, there is a risk of improper development of the genital organs of boys.
In the third - a categorical prohibition - it is possible to contract the uterus. There is a threat of abortion.

Price of Nurofen

In Russia, the drug comes from the UK, Greece, its cost depends on customs costs, the seller's margin. The medicine should be ordered at an online pharmacy or bought at a nearby one. How much does Nurofen cost, you can see in the table:

Release form

From early childhood, a person is haunted by pain and inflammation. To get rid of these problems resort to drug therapy, using appropriate drugs. One of these medicines is Nurofen, which has an analgesic and anti-inflammatory effect.

Dosage form

Pharmacological agent "Nurofen" is available in the following forms:

coated tablets, white, packed in blisters;
gel intended for topical use, transparent, has the smell of alcohol, is sold in aluminum tubes;
Nurofen syrup for children, with the taste of orange or strawberry, is bottled in plastic bottles;
rectal suppositories for children, painted white, have a torpedo-like shape;
capsules, oval, covered with a translucent gelatin shell, painted in red.

The composition of the drug

The active ingredient of the drug, released in any dosage form, is ibuprofen. The amount of this substance varies depending on the form of release. The auxiliary elements included in the composition contribute to the better absorption of Nurofen.

One tablet of Nurofen contains 200 mg of the active ingredient. There are several types of tablet preparation:

Nurofen Express capsules, like regular dragees, includes 200 mg of the active ingredient.
Nurofen Plus, which, in addition to ibuprofen, includes 10 mg of codeine.
Nurofen Forte containing 400 mg of the active element.

For 5 ml of syrup there are 100 mg of the active ingredient. One rectal suppository contains 60 mg of ibuprofen and solid fat.

100 gr. gel Nurofen contains 5 gr. active element.

Description of pharmacological properties

The drug Nurofen, thanks to ibuprofen, which is part of it, has a pronounced anti-inflammatory, analgesic and antipyretic effect on the body.

The drug inhibits the synthesis of hormone-like substances called prostaglandins. They contribute to the development of inflammation, pain and hyperthermic reaction. In addition, the active component of Nurofen thins the blood and blocks the adhesion of platelets to each other.

After oral administration, high absorption is noted, the drug is quickly and almost completely absorbed from the digestive tract. The highest concentration of ibuprofen in the blood is observed after 45 minutes, provided that Nurofen was taken on an empty stomach. If the drug is taken with food, the time to reach the maximum level increases to 1-2 hours.

The drug penetrates into the joint cavities and synovial fluid, remaining in it for a long time. Its level in this liquid is much higher than in blood plasma. In the cerebrospinal fluid, a lower content of the active component of Nurofen is detected in relation to the blood plasma.

Studies have also shown that small amounts of ibuprofen are present in breast milk.

In the liver, the drug is metabolized, excreted by the kidneys and partly by the intestines. The withdrawal time is 120 minutes.

Indications for admission

The drug is prescribed if the patient has the following conditions:

headache;
pain syndrome with various lesions of the tooth;
pain during teething;
migraine;
periodic pain in women;
muscle pain;
pain associated with damage to the musculoskeletal system and injuries;
back pain;
Ear ache;
articular inflammatory processes;
neuralgia;
fever in acute respiratory infections and acute respiratory viral infections.

Instructions for using the medication

The tactics of treatment with Nurofen depends on the age of the patient and the clinical picture of the disease. The drug is used only as prescribed by the treating specialist.

Pills

Instructions for the drug

Nurofen tablets are taken orally after a meal. To reduce the aggressive effect of the active component on the mucous membrane of the digestive organs, the medicine is washed down with plenty of water. Effervescent tablets are dissolved in a glass of liquid.

Patients over 12 years of age are shown three or four times daily intake of 200 mg of the drug, while it is necessary to adhere to an interval of 4 hours. In the initial stages of therapy, a single dose of the drug in adults can reach 400 mg, then it is halved, to 200 mg.

The daily norm for children aged 6-12 years is the use of one tablet of Nurofen no more than 4 times. The interval between doses should exceed 6 hours. Nurofen capsules, like tablets, are allowed to be used in the treatment of children whose body weight exceeds 20 kg. If there is no improvement within 2-3 days, stop using the product and seek medical advice.

The dose of medication for a child is 1 tablet

To eliminate headache and toothache, a single application of the drug is sufficient.

It is forbidden to use more than 1200 mg (6 tablets) of the drug in 24 hours.

Gel

Nurofen Gel is for external use only. Intended for patients over 12 years of age. It is necessary to squeeze out about 50-120 mg from the tube, which is equivalent to 4-10 cm of medication. Then you should carefully rub the drug into the skin until it is completely absorbed.

Re-use of the gel is possible only after 4 hours and four times the use of the drug is permissible in 24 hours.

In the absence of improvement and the persistence of symptoms after 14 days of using the medication, it is worth stopping and seeking medical help.

It is forbidden to apply the medication to damaged skin, the area around the eyes, lips. Avoid getting the gel in your eyes and mouth. If the remedy was accidentally taken orally, it is necessary to rinse the mouth thoroughly and consult a specialist.

If the product was taken orally, then it is necessary to rinse the oral cavity thoroughly.

Syrup

Nurofen syrup for children is intended for oral administration. The dose of the drug depends on the body weight of the child and his age. Three or four times the drug is shown.

If your baby has a cold, fever, or infection, the doses listed below are recommended:

age 3-6 months, weight less than 5 kg - 2.5 ml;
age from 6 months to a year, weight up to 10 kg - 2.5 ml;
age 1-3 years, weight up to 15 kg - 5 ml;
age 4-6 years, weight less than 20 kg - 7.5 ml;
age 7-9, body weight below 30 kg - 10 ml;
age 10-12 years, weight up to 40 kg - 15 ml.

Do not exceed this dosage. If improvements are observed from the use of the drug, a dose reduction is allowed.

Before use, the medicine must be shaken.

Candles

Suppositories are used in children with a fever or pain syndrome. The dose of Nurofen depends on the weight of the child. Recommended for use in children weighing more than 6 kg. They are administered rectally.

According to the instructions, the maximum allowable daily dose is 30 mg / kg of patient weight. It is necessary to monitor the interval for using candles, it should not exceed 6 hours.

Children from 3 to 9 months (corresponding to a body weight of 6-8 kg) are administered 1 suppository 3 times / day. The daily rate should not exceed 180 mg.

Children older than 9 months, but younger than 2 years (equivalent to a body weight of 8-12 kg) are shown four times the use of 1 suppository per day, not exceeding the norm of 240 mg.

The lack of improvement and the persistence of symptoms in babies 3-5 months during the day or after 3 days in children from 6 months when using the medication forces you to seek the help of a specialist.

If the symptoms of the disease persist in babies for several days, then you need to contact a specialist.

With hyperthermia after vaccination, children under one year old are given 1 suppository. If necessary, use an additional candle. It is not recommended to use more than 2 suppositories during the day.

Existing contraindications

Before using the drug Nurofen, it is necessary to study in detail the instructions for the drug for existing contraindications.

In the presence of these diseases and conditions, a person is prohibited from taking Nurofen:

individual intolerance to ibuprofen or other components of the drug;
the presence of erosive and ulcerative diseases of the digestive organs (gastric and intestinal ulcers, ulcerative colitis, Crohn's disease), the active phase of internal bleeding;
chronic diseases of the respiratory tract;
disorder of normal renal and hepatic activity;
blood clotting disorder;
recent surgery on large blood vessels;
bronchial asthma;
fructose malabsorption;
inflammation of the nasal mucosa;
pregnancy (1st and 3rd trimesters);
lactation period;
children's age up to 6 years.

It is allowed to take the drug if the patient has the following conditions, but with extreme caution:

Side effects

To minimize the risk of adverse reactions, it is necessary to take the medication in a short course, using the minimum dose that can eliminate the symptoms. Negative phenomena are not observed if Nurofen was used for 2-3 days.

From the digestive tract: nausea, indigestion, bloating, heartburn, pain localized in the stomach. Rarely, diarrhea, vomiting, and constipation are noted. Very rarely - vomiting of bloody masses, peptic ulcer, melena, gastritis. Among elderly patients sometimes ended in death.

Bloating can act as a side effect while taking the drug.

From the side of the liver and biliary tract: quite rarely, the normal functioning of the liver is disturbed, there is a jump in the activity of liver enzymes, hepatitis, yellowing of the skin and mucous membranes.

From the circulatory system: peripheral edema, heart failure, increased blood pressure. With prolonged use of Nurofen, the risk of thrombotic complications increases.

Thromboembolic complications

From the immune system: hypersensitivity, nonspecific allergic and anaphylactic reactions, allergic rhinitis, eosinophilia are rarely noted. Skin negative reactions to the drug appear as itching, urticaria, angioedema, bullous dermatoses.

From the side of the respiratory system: effects on the respiratory system, leading to the appearance of shortness of breath, suffocation, bronchial asthma.

From the excretory system: quite rarely, acute renal failure develops, typical for long-term use of the drug, together with an increase in the amount of urea in the blood and the formation of edema. And also nephritic syndrome, hematuria and proteinuria, nephrotic syndrome, cystitis are noted.

Analogues

There are a large number of analogues that have properties similar to Nurofen. You can replace it with such medicines:

Ibuprom.
Gofen.
Ibufen.
Ibutex.
Nemigesic.

From this medical article you can get acquainted with the drug Nurofen. Instructions for use will explain in which cases you can take the medicine, what it helps with, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Nurofen, from which you can find out if the medicine helped in the treatment of pain and fever (fever) in adults and children. The instructions list Nurofen analogues, drug prices in pharmacies, as well as its use during pregnancy.

Anti-inflammatory, analgesic, antipyretic drug is Nurofen. Instructions for use for children and adults recommend taking syrup, tablets, gel and suppositories for the treatment of rheumatic diseases, as well as for relieving inflammation, fever and pain. In pediatric practice, Nurofen is effective as an antipyretic for colds and teething fever.

Release form and composition

Pharmacies receive:

Film-coated tablets 200 mg.
Tablets for the preparation of an effervescent drink 200 mg.
Candles rectal 60 mg (children's form of the drug).
Nurofen forte 400mg tablets.
Nurofen plus tablets (contains ibuprofen + codeine).
Children's syrup or suspension with orange or strawberry flavor 100 mg.
Gel for external use 5%.

One tablet contains 200 mg of ibuprofen and auxiliary components. Composition of Nurofen in the form of effervescent tablets: 200 mg of ibuprofen and additional substances The drug is sold in tubes of 10 tablets.

Suspension composition: 100 mg of ibuprofen per 5 ml of suspension. The drug is available in 100 ml vials.

The composition of rectal suppositories includes 60 mg of ibuprofen (in one suppository) and solid fat. Candles are sold in packs of 10.

Nurofen in the form of a 5% gel for external use is available in tubes of 20, 30, 50 or 100 grams. 1 g of the drug contains 50 mg of ibuprofen.

Pharmacological properties

The active substance in the composition of Nurofen, the instructions for use confirm this, is ibuprofen, a derivative of phenylpropionic acid.

When taken orally, it inhibits the formation of prostaglandins - substances that cause an inflammatory reaction in the human body (the so-called inflammatory mediators), due to which there is an anti-inflammatory, analgesic and antipyretic effect.

There are reviews about Nurofen by researchers, indicating that it stimulates the production of the body's own interferon, a substance that is one of the main factors of immunity.

Thus, one of the additional actions of ibuprofen is the stimulation of immunity, which makes the use of the drug justified in the treatment of viral infections.

What helps Nurofen?

Indications for the use of the drug include:

Instructions for use

Pills

Nurofen for children over 12 years of age and adults is prescribed at an initial dose of 200 mg 3-4 times a day. To achieve a rapid clinical effect, it is possible to increase the initial dose to 400 mg 3 times a day. The maximum daily dose is 1200 mg. Children aged 6 to 12 years - 200 mg no more than 4 times a day.

It should be borne in mind that the drug can only be prescribed to children weighing more than 20 kg. The interval between taking the tablets should be at least 6 hours. Do not take more than 6 tablets per day. The maximum dose is 1.2 g. Coated tablets should be taken with water. Effervescent tablets should be dissolved in 200 ml of water (1 cup).

Candles for children

With fever and pain syndrome, the dose of the drug depends on the age and body weight of the child. A single dose is 5-10 mg / kg 3-4 times a day. The maximum daily dose is 30 mg/kg.

Children aged 3-9 months (body weight 5.5-8 kg) are prescribed 1 supp. (60 mg) 3 times a day with an interval of 6-8 hours, but not more than 180 mg per day. Children aged 9 months to 2 years (body weight 8-12.5 kg) are prescribed 1 supp. (60 mg) 4 times a day with an interval of 6 hours, not more than 240 mg per day.

With post-immunization fever, children under the age of 1 year are prescribed 1 supp. (60 mg); children over 1 year also - 1 supp. (60 mg), if necessary, after 6 hours, you can enter 1 more supp. (60 mg). Duration of treatment: no more than 3 days as an antipyretic, no more than 5 days as an analgesic.

If the fever persists, then a doctor's consultation is necessary. Do not exceed the indicated doses of the drug.

Suspension or baby syrup

Nurofen for fever and pain syndrome, the drug is prescribed at a dose of 5-10 mg / kg of body weight of a child 3-4. The maximum daily dose should not exceed 30 mg/kg of body weight. As an antipyretic, the drug should not be taken for more than 3 days, as an analgesic - no more than 5 days.

With fever after immunization, the drug is prescribed at a dose of 50 mg (2.5 ml); if necessary, children older than 1 year after 6 hours, it is possible to take the drug again at the same dose. The maximum daily dose should not exceed 5 ml (100 mg).

The suspension should be shaken well before use. For accurate dosing of the suspension, a double-sided measuring spoon (for 2.5 ml and 5 ml) or a measuring syringe is attached to the vial.

Contraindications

Nurofen and analogues should not be used if the patient has the following diseases and factors:

age up to 3 months;
severe heart failure;
violation of the functionality of the kidneys or liver;
III trimester of pregnancy and lactation period;
hypersensitivity to NSAIDs and the composition of the drug Nurofen, from which tablets and other forms can cause allergies;
blood diseases;
ophthalmic diseases;
aspirin triad;
erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
severe arterial hypertension;
pathology of the inner and middle ear;
hemorrhagic diathesis.

Side effects

In the process of taking the medicine, the following side reactions of the body can be observed:

anorexia;
feeling of discomfort in the epigastrium;
erosive and ulcerative lesions of the gastrointestinal tract (in some cases, complicated by perforation and bleeding);
abdominal pain, irritation;
diarrhea;
nausea, vomiting;
constipation;
heartburn;
flatulence;
headache;
blurred vision;
thrombocytopenia;
acute renal failure;
allergic rhinitis;
dizziness;
tachycardia;
confusion, hallucinations;
nephrotic syndrome;
agranulocytosis;
leukopenia;
dryness and pain in the oral mucosa;
insomnia, agitation, drowsiness, depression;
dryness and irritation of the eyes;
hearing loss, ringing or tinnitus;
increased sweating;
thrombocytopenic purpura;
increase in blood pressure;
bronchospasm, shortness of breath;
anemia (including hemolytic, aplastic);
skin rash, itching, urticaria, angioedema, anaphylactoid reactions, shock.

Children, during pregnancy and lactation

For newborns and children under 6 years of age, the drug in tablets is contraindicated. Children from 6 to 12 years of age should receive a single dose of 200 mg of drugs no more than 4 times a day.

The gel is not prescribed for children under 12 years of age.

Nurofen is contraindicated for use in the 3rd trimester of pregnancy. The use of the drug in the 1st and 2nd trimesters of pregnancy is possible only if the intended benefit to the mother outweighs the potential risk to the fetus or infant. If necessary, the appointment of the drug during lactation should decide on the termination of breastfeeding.

special instructions

When taking effervescent tablets, patients on a hypokalemia diet should take into account that 1 tablet contains 1530 mg of potassium carbonate; patients with diabetes should take into account that 1 tablet contains 40 mg of sodium saccharinate; patients with fructose intolerance should take into account that 1 tablet contains about 376 mg of sorbitol.

drug interaction

You should not take Nurofen and Acetylsalicylic acid at the same time, as well as other NSAIDs. Ibuprofen reduces the antiplatelet and anti-inflammatory effect of acetylsalicylic acid. Also, in patients who take Acetylsalicylic acid as an antiplatelet agent, after taking ibuprofen, the incidence of acute coronary insufficiency increases.

The risk of bleeding increases if Nurofen and anticoagulants, thrombolytic agents are taken simultaneously. The simultaneous use of ibuprofen and Cefoperazone, Cefamandol, Plikamycin, Cefotetan, Valproic acid increases the incidence of hypoprothrombinemia.

Nurofen's analogs

Active ingredient analogs:

Holiday conditions and price

The average price of Nurofen (tablets) in Moscow is 184 rubles. In Kyiv, you can buy medicine for 92 hryvnia, in Kazakhstan - for 815 tenge. In Minsk, pharmacies offer an analogue of Aertal (Table 100 mg No. 20) for 11-17 bel. rubles. It is released from pharmacies by prescription.

INSTRUCTIONS for the use of a medicinal product for medical use

Registration number: P N013012/01-090117

Trade name of the drug: Nurofen ®

International non-proprietary name (INN): ibuprofen

Chemical Name:(2RS)-2--propionic acid

Dosage form: coated tablets

Compound
One coated tablet contains the active ingredient ibuprofen 200 mg;
Excipients: croscarmellose sodium 30 mg, sodium lauryl sulfate 0.5 mg, sodium citrate dihydrate 43.5 mg, stearic acid 2 mg, colloidal silicon dioxide 1 mg.
shell composition: sodium carmellose 0.7 mg, talc 33 mg, acacia gum 0.6 mg, sucrose 116.1 mg, titanium dioxide 1.4 mg, macrogol 6000 0.2 mg, black ink [Opacode S-1-277001] (shellac 28.225%, iron dye black oxide (E172) 24.65%, propylene glycol 1.3%, isopropanol* 0.55%, butanol* 9.75%, ethanol* 32.275%, purified water* 3.25%).
*Solvents evaporated after the printing process.

Description
White or off-white, round, biconvex film-coated tablets with Nurofen black overprint on one side of the tablet. On the cross section of the tablet, the core is white or almost white, the shell is white or almost white.

Pharmacotherapeutic group: non-steroidal anti-inflammatory drug (NSAID).

ATC code: M01AE01

Pharmacological properties
Pharmacodynamics
The mechanism of action of ibuprofen, a propionic acid derivative from the group of non-steroidal anti-inflammatory drugs (NSAIDs), is due to inhibition of the synthesis of prostaglandins - mediators of pain, inflammation and hyperthermic reaction. Indiscriminately blocks cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), as a result of which it inhibits the synthesis of prostaglandins. It has a fast directed action against pain (pain reliever), antipyretic and anti-inflammatory action. In addition, ibuprofen reversibly inhibits platelet aggregation. The analgesic effect of the drug lasts up to 8 hours.

Pharmacokinetics
Absorption - high, quickly and almost completely absorbed from the gastrointestinal tract (GIT). After taking the drug on an empty stomach, the maximum concentration (C max) of ibuprofen in the blood plasma is reached after 45 minutes. Taking the drug with food can increase the time to reach maximum concentration (TC max) up to 1-2 hours. Communication with blood plasma proteins - 90%. It slowly penetrates into the joint cavity, lingers in the synovial fluid, creating higher concentrations in it than in the blood plasma. In the cerebrospinal fluid, lower concentrations of ibuprofen are found compared to blood plasma. After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form. It is metabolized in the liver. The half-life (T1 / 2) is 2 hours. It is excreted by the kidneys (in unchanged form, not more than 1%) and, to a lesser extent, with bile.
In limited studies, ibuprofen has been found in breast milk at very low concentrations.

Indications for use

Nurofen ® is used for headache, migraine, toothache, painful menstruation, neuralgia, back pain, muscle pain, rheumatic pain and joint pain; as well as in a feverish state with influenza and colds.

Contraindications

Hypersensitivity to ibuprofen or any of the components that make up the drug.
Complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including history).
Erosive and ulcerative diseases of the gastrointestinal tract (including peptic ulcer of the stomach and duodenum, Crohn's disease, ulcerative colitis) or ulcer bleeding in the active phase or in history (two or more confirmed episodes of peptic ulcer or ulcer bleeding).
Bleeding or perforation of an ulcer of the gastrointestinal tract in history, provoked by the use of NSAIDs.
Severe heart failure (NYHA class IV - classification of the New York Heart Association)
Severe liver failure or active liver disease.
Severe renal failure (creatinine clearance< 30 мл/мин), подтвержденная гиперкалиемия.
Decompensated heart failure; period after coronary artery bypass grafting.
Cerebrovascular or other bleeding.
Fructose intolerance, glucose-galactose malabsorption, sucrase-isomaltase deficiency.
Hemophilia and other blood clotting disorders (including hypocoagulation), hemorrhagic diathesis.
Pregnancy (III trimester).
Children's age up to 6 years.

Carefully
If you have the conditions listed in this section, you should consult a doctor before using the drug.
Simultaneous use of other NSAIDs, a history of a single episode of gastric ulcer and duodenal ulcer or ulcerative bleeding of the gastrointestinal tract; gastritis, enteritis, colitis, Helicobacter pylori infection, ulcerative colitis; bronchial asthma or allergic diseases in the acute stage or in history - bronchospasm may develop; systemic lupus erythematosus or mixed connective tissue disease (Sharpe's syndrome) - increased risk of aseptic meningitis; chicken pox; renal failure, including dehydration (creatinine clearance less than 30-60 ml / min), nephrotic syndrome, liver failure, cirrhosis of the liver with portal hypertension, hyperbilirubinemia, arterial hypertension and / or heart failure, cerebrovascular diseases, blood diseases of unknown etiology ( leukopenia and anemia), severe physical illness, dyslipidemia/hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, frequent alcohol use, concomitant use of drugs that may increase the risk of ulcers or bleeding, in particular oral glucocorticosteroids (including prednisolone ), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline) or antiplatelet agents (including acetylsalicylic acid, clopidogrel), pregnancy I-II trimester, breastfeeding period, elderly

age, under 12 years of age.
Use during pregnancy and during breastfeeding

The use of the drug in the third trimester of pregnancy is contraindicated. The use of the drug in the I-II trimesters of pregnancy should be avoided; if necessary, the drug should be taken with a doctor. There is evidence that small amounts of ibuprofen can pass into breast milk without any negative effects on the health of the infant, so usually with short-term use, there is no need to stop breastfeeding. If you need long-term use of the drug, you should consult a doctor to decide whether to stop breastfeeding for the period of drug use.

Dosage and administration
For oral administration. Patients with hypersensitivity of the stomach are recommended to take the drug during meals.

Adults and children over 12 years old: inside 1 tablet (200 mg) up to 3-4 times a day. The tablets should be taken with water. To achieve a faster therapeutic effect in adults, the dose may be increased to 2 tablets (400 mg) up to 3 times a day.

Children from 6 to 12 years old: 1 tablet (200 mg) up to 3-4 times a day; the drug can be taken only if the child's body weight is more than 20 kg. The interval between taking the tablets should be at least 6 hours. The maximum daily dose for adults is 1200 mg (6 tablets). Maximum daily dose for children from 6 to 18 years: 800 mg (4 tablets). If, when taking the drug for 2-3 days, the symptoms persist or intensify, it is necessary to stop treatment and consult a doctor.

Side effect

The risk of side effects can be minimized if the drug is taken in a short course, in the minimum effective dose necessary to eliminate symptoms.

In the elderly, there is an increased frequency of adverse reactions during the use of NSAIDs, especially gastrointestinal bleeding and perforation, in some cases with a fatal outcome. Side effects are predominantly dose-dependent. The following adverse reactions were noted with short-term use of ibuprofen in doses not exceeding 1200 mg / day (6 tablets).

In the treatment of chronic conditions and with prolonged use, other adverse reactions may occur.

The incidence of adverse reactions was assessed based on the following criteria: very frequent (≥ 1/10), frequent (from ≥1/100 to< 1/10), нечастые (от ≥ 1/1000 до < 1/100), редкие (от ≥ 1/10 000 до < 1/1000), очень редкие (< 1/10 000), частота неизвестна (данных для оценки частоты недостаточно).

Blood and lymphatic system disorders

Very rare: hematopoietic disorders (anemia, leukopenia, aplastic anemia, hemolytic anemia, thrombocytopenia, pancytopenia, agranulocytosis). The first symptoms of such disorders are fever, sore throat, superficial oral ulcers, flu-like symptoms, severe weakness, nosebleeds and subcutaneous hemorrhages, bleeding and bruising of unknown etiology.

Immune System Disorders

Infrequent: hypersensitivity reactions - nonspecific allergic reactions and anaphylactic reactions, reactions from the respiratory tract (bronchial asthma, including its exacerbation, bronchospasm, shortness of breath, dyspnea), skin reactions (itching, urticaria, purpura, Quincke's edema, exfoliative and bullous dermatoses , including toxic epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome, erythema multiforme), allergic rhinitis, eosinophilia.
Very rare: severe hypersensitivity reactions, including swelling of the face, tongue and throat, shortness of breath, tachycardia, hypotension (anaphylaxis, angioedema or severe anaphylactic shock).

Gastrointestinal disorders

Uncommon: abdominal pain, nausea, dyspepsia (including heartburn, bloating).
Rare: diarrhea, flatulence, constipation, vomiting.
Very rare: peptic ulcer, perforation or gastrointestinal bleeding, melena, hematemesis, in some cases fatal, especially in elderly patients, ulcerative stomatitis, gastritis.
Frequency unknown: exacerbation of colitis and Crohn's disease.

Liver and biliary tract disorders

Very rare: abnormal liver function, increased activity of "liver" transaminases, hepatitis and jaundice.

Renal and urinary tract disorders

Very rare: acute renal failure (compensated and decompensated), especially with prolonged use, in combination with an increase in the concentration of urea in the blood plasma and the appearance of edema, hematuria and proteinuria, nephritic syndrome, nephrotic syndrome, papillary necrosis, interstitial nephritis, cystitis.

Nervous System Disorders

Uncommon: headache.
Very rare: aseptic meningitis.
Cardiovascular disorders
Frequency unknown: heart failure, peripheral edema, prolonged use increases the risk of thrombotic complications (eg, myocardial infarction), increased blood pressure.

Respiratory and mediastinal disorders

Frequency unknown: bronchial asthma, bronchospasm, shortness of breath.

Laboratory indicators

hematocrit or hemoglobin (may decrease)
bleeding time (may increase)
plasma glucose concentration (may decrease)
creatinine clearance (may decrease)
plasma creatinine concentration (may increase)
activity of "liver" transaminases (may increase)

If side effects occur, stop taking the drug and consult a doctor.

Overdose
In children, overdose symptoms may occur after taking a dose in excess of 400 mg / kg body weight. In adults, the dose-dependent effect of overdose is less pronounced. The half-life of the drug in case of overdose is 1.5-3 hours.
Symptoms: nausea, vomiting, epigastric pain or, less commonly, diarrhea, tinnitus, headache, and gastrointestinal bleeding. In more severe cases, manifestations from the central nervous system are observed: drowsiness, rarely - agitation, convulsions, disorientation, coma. In cases of severe poisoning, metabolic acidosis and an increase in prothrombin time, renal failure, liver tissue damage, lowering blood pressure, respiratory depression and cyanosis may develop. In patients with bronchial asthma, an exacerbation of this disease is possible.
Treatment: symptomatic, with the obligatory provision of airway patency, ECG monitoring and basic vital signs up to the normalization of the patient's condition. Oral activated charcoal or gastric lavage is recommended within 1 hour of a potentially toxic dose of ibuprofen. If ibuprofen has already been absorbed, an alkaline drink may be given to eliminate the acidic ibuprofen derivative by the kidneys, forced diuresis. Frequent or prolonged seizures should be treated with intravenous diazepam or lorazepam. With the worsening of bronchial asthma, the use of bronchodilators is recommended.

Interaction with other drugs

The concomitant use of ibuprofen with the following medicinal products should be avoided:

Acetylsalicylic acid: with the exception of low doses of acetylsalicylic acid (no more than 75 mg per day) prescribed by a doctor, since combined use may increase the risk of side effects. With the simultaneous use of ibuprofen, it reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (it is possible to increase the incidence of acute coronary insufficiency in patients receiving low doses of acetylsalicylic acid as an antiplatelet agent after starting ibuprofen).
Other NSAIDs, in particular selective COX-2 inhibitors: the simultaneous use of two or more drugs from the NSAID group should be avoided due to a possible increase in the risk of side effects.

Use with caution concomitantly with the following medicinal products
means:

special instructions
It is recommended to take the drug for the shortest possible course and in the minimum effective dose necessary to eliminate symptoms. If you need to take the drug for more than 10 days, you should consult a doctor.
In patients with bronchial asthma or an allergic disease in the acute stage, as well as in patients with a history of bronchial (asthma / allergic disease), the drug may provoke bronchospasm. The use of the drug in patients with systemic lupus erythematosus or mixed connective tissue disease is associated with an increased risk of developing aseptic meningitis.

During long-term treatment, it is necessary to control the picture of peripheral blood and the functional state of the liver and kidneys. When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, complete blood count (hemoglobin determination), fecal occult blood analysis. If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study. During the treatment period, ethanol is not recommended.

Patients with renal insufficiency should consult a doctor before using the drug, as there is a risk of deterioration in the functional state of the kidneys.

Patients with hypertension, including a history of and / or chronic heart failure, should consult a doctor before using the drug, since the drug may cause fluid retention, increased blood pressure and edema.
In patients with uncontrolled hypertension, NYHA class II-III congestive heart failure, ischemic heart disease, peripheral arterial disease and/or cerebrovascular disease, ibuprofen should be prescribed only after a careful assessment of the benefit-risk ratio, and high doses of ibuprofen should be avoided (> 2400 mg/day).

The use of NSAIDs in patients with chickenpox may be associated with an increased risk of developing severe purulent complications of infectious and inflammatory diseases of the skin and subcutaneous fat (for example, necrotizing fasciitis). In this regard, it is recommended to avoid the use of the drug for chicken pox.

Information for women planning pregnancy: the drug inhibits cyclooxygenase and prostaglandin synthesis, affects ovulation, disrupting female reproductive function (reversible after discontinuation of treatment).

Influence on the ability to drive vehicles, mechanisms.
Patients who experience dizziness, drowsiness, lethargy, or visual disturbances while taking ibuprofen should avoid driving or operating machinery.

Release form
Film-coated tablets 200 mg.
6, 8, 10 or 12 tablets per blister (PVC / PVDC / aluminum). One blister (6, 8, 10 or 12 tablets each) or two blisters (6, 8, 10 or 12 tablets each) or 3 blisters (10 or 12 tablets each) or 4 blisters (12 tablets each) or 8 blisters (each 12 tablets) together with instructions for use are placed in a cardboard box.

Storage conditions
Store at a temperature not exceeding 25 °C. Keep out of the reach of children.

Best before date
3 years.
Do not use an expired drug.

Holiday conditions
Over the counter.

The legal entity in whose name the registration certificate is issued and the manufacturer

Reckitt Benckiser Healthcare International Ltd, Thane Road, Nottingham, NG90 2DB, UK

Representative in Russia/Consumer Claims Receiver
Reckitt Benckiser Healthcare LLC
Russia, 115114, Moscow, Shluzovaya nab., 4

Nurofen is the first over-the-counter drug based on the market. For 30 years it has been produced by the British giant - Reckitt Benckiser. By action, it is an analgesic and antipyretic agent belonging to the non-steroidal group of anti-inflammatory drugs. It is the most popular pain reliever in Europe and Australia. You can find it in pharmacies in 40 countries around the world.

Forms of the drug

When you ask for Nurofen at the pharmacy, they will definitely ask you: “Which one?”. Not only pharmacists, but also marketers are working on the breadth of the product range. Reckitt Benckiser ranked 1st in 2016 in terms of investments in TV advertising in Russia (brands Nurofen, Durex, Air Wick, Calgon, Vanish and others), and is known not only for the quality of its products, but also for powerful advertising companies. The manufacturer of Nurofen is a solid pharmaceutical company, but without the desire for profit, it would not become one of the richest companies in the world.

In 2016, Reckitt Benckiser was fined by the Federal Court of Australia. The British owners paid a hefty amount of what Australian consumer advocates say was misleading consumers with advertisements releasing separate types of the drug against periodical, dental, rheumatic and other types of pain with an identical composition of Nurofen.

The judges saw this specialization as a marketing ploy designed to force the consumer to purchase the same pills in different packages. European countries are now also studying this issue.

The form of the drug depends on how long Nurofen begins to act. The liquid form (capsules) is most rapidly absorbed into the intestine. In them, the active substance is in a biologically more accessible form. How long does Nurofen last? Depending on the individual characteristics of the body, up to 8 hours.

From the above figures, it can be seen that the price of Nurofen depends not only on the form of the drug, but also on the sauce under which this medicine is presented to the consumer. So what to choose? The liquid form really works a little faster, so if 10-15 minutes plays a role, choose capsules.

In Russia, Nurofen “new products” come out one after another: special pills for migraine, for example.

Nurofen dosages of 200 mg usually cope with pain of moderate intensity, including common migraine and occasional pain. Try not to abuse medications, start with small doses. After all, if you put three pills in front of you at once, and offer you to drink them in one fell swoop, it will scare you. And by taking Nurofen Multisymptom, you are, in fact, doing just that.

Start with a dosage of 200 mg and don't expect an immediate effect. To evaluate the result, at least 50 minutes must elapse.

How to apply

Instructions for using Nurofen are similar for different variations of the same form. Ibuprofen as an antipyretic should not be used for longer than 3 days. When taken on an empty stomach, the drug will work faster, but if you have a sensitive stomach, it is better to take it with food.

Drink with a whole glass of water. It is dangerous to take ibuprofen and aspirin, anticoagulants at the same time, since this combination increases the risk of side effects. This medicine reduces the effectiveness of diuretics and antihypertensive drugs.

You should also consult your doctor before taking Nurofen if you are prescribed cardiac glycosides.

For adults

Nurofen for adults is used to relieve pain of any origin of mild to moderate intensity, that is, for any "household" pain. It doesn’t matter if your husband has a headache, and you only have pills “for the lady” at home - they will help.

You can also pour suspensions, adjusting the dosage. It is less popular in Russia to use ibuprofen as an antipyretic for adults, however, such use of the drug is acceptable. The maximum daily dose is 1200 mg.

During pregnancy, the drug can be used only the first 2 trimesters. Ibuprofen passes into breast milk in small doses that do not harm the baby.

Nurofen and alcohol should not be combined. Both substances have a strong effect on the liver, and the higher the dose of the active substance and the larger the portion of alcohol, the more the combination will hit the liver and kidneys. Even with the use of a pill to relieve a hangover symptom, the risk of side effects increases, since the body still contains alcohol. For people with chronic alcoholism, the drug is contraindicated.

For children

All Nurofen preparations for children are indicated as an antipyretic, including after vaccinations, and also as an analgesic, regardless of the cause of the pain. It is impossible to combine taking drugs of different forms (for example, simultaneously give a suspension and administer a suppository), it is necessary to withstand at least 6 hours between doses.

Which is better, Nurofen or paracetamol for children? Both drugs are antipyretics and pain relievers that are recommended by pediatricians as the safest and most effective. However, their mechanism of action is different.

Nurofen lowers fever faster, its effect is longer (6-8 hours), but it has slightly more possible side effects. Doctors call paracetamol a first-line help for children with a temperature, and assign ibuprofen only second place (second-choice drug).

Suspension

Nurofen suspension for children from 3 months to 9 years has 5 mg of active ingredient in 1 ml of the product, and therefore the dose is calculated based on the age and weight of the child. Many mothers prefer to give Nurofen suspension to their children. He likes kids.

In addition, a smaller amount of product is required compared to popular paracetamol-based preparations. And this is very important when the child has a temperature and refuses to take any medication. A common reaction to any sweet suspension at this point is vomiting.

In order for the baby to be able to swallow the medicine without unpleasant consequences, give 1-2 ml of the suspension every 3-5 minutes, pouring it over the cheek. Let's drink some water each time.

When choosing a dosage, you should focus more on the weight of the child than on the indicated age.

Candles for children

The active substance of rectal suppositories is absorbed by the body longer. At very high temperatures, the suspension will work faster. But you can put a candle before going to bed if you are afraid that the temperature will rise above 38.3 at night. A suppository is suitable if the child refuses to drink the medicine, or if the sweet syrup causes him to gag. In some babies, suppositories "do not linger", working as a laxative. To identify which form of the drug is more suitable for your child, you can only experimentally.

The suppository should be gently inserted into the baby's anus. With a body weight of 6-8 kg, you can use no more than 3 candles per day, with a child weighing 8-12 kg - no more than 4, with an interval of 6-8 hours.

Tablets for children

For children from 6 to 12 years old, the manufacturer offers tablets of "a convenient streamlined shape, in a smooth glaze." Otherwise - all the same 200 mg of the active ingredient. Take no more than 4 tablets per day with an interval of at least 6 hours.

Contraindications

There are quite a few contraindications for Nurofen. In addition to the standard “individual intolerance”, these are also ulcers and erosions of the gastrointestinal tract, severe forms of hepatic, renal and heart failure, blood diseases (clotting disorders), and some others.

In the presence of chronic and acute diseases, taking other drugs, check with your doctor if you can use ibuprofen.

Side effects

Side effects are especially common in elderly patients. Side effects of Nurofen can be a variety of manifestations of disorders of the gastrointestinal tract, liver and kidneys, heart failure, nosebleeds, skin rashes and allergic rhinitis, and a rather long list, which can be found in the annotation. They occur infrequently, their strength is related to the dosage. The lower the dose of ibuprofen and the less often you use this pain reliever, the less likely they are to occur.

An overdose of Nurofen in children occurs at a dose of more than 400 mg of the active substance per kg of body weight. The consequences can be up to death. Adults are less at risk. In case of an overdose, induce vomiting and go to an ambulance.

Nurofen and analogues

The active ingredient in Nurofen is ibuprofen. Preparations with the same composition are produced today by many pharmaceutical companies. Claiming that all medicines are the same because the composition is the same is the same as saying that the food in an expensive restaurant and a school cafeteria is the same (the ingredients are the same).

Both there and there have their own processing nuances, additives and other secrets that neither manufacturers nor chefs will discover. Below is a list of complete Nurofen analogues containing the same active substance.

Full analogues:

Nurofen is a proven drug that has earned the trust of generations. The cost of packing a regular tablet form is quite affordable, not higher than many analogues, and the quality is undeniable. Whether to choose Nurofen's "fashionable" forms, overpaying for a beautiful box, is up to the end consumer to decide.