Every fourth woman has iron deficiency anemia to one degree or another. This condition also occurs in men, but more often in girls, since their body is exposed to monthly blood loss. The modern drug "Sorbifer Durules" is effective for anemia of any etiology. This is a modern combination drug that also contains ascorbic acid. At the same time, it has a fairly reasonable price. Instructions, reviews of Sorbifer Durules, dosage and method of administration - everything is described in this article.

What is iron deficiency anemia and how does it manifest?

Previously, this diagnosis was known as anemia. People have long noticed that women sometimes experience symptoms that reduce the quality of life: pallor, weakness, lack of vital energy. With the development of microbiology, it became clear that anemia is a condition that occurs with prolonged iron deficiency.

Iron deficiency anemia is the most common form of all currently known anemia, which is due to a large number of reasons and circumstances that can lead to iron deficiency, which will lead to various disorders that are unsafe for the body.

Symptoms of iron deficiency anemia:

• constant weakness;
• lack of taste for life;
• asthenia, dysphoria, anhedonia;
• mental problems: increased vulnerability, anxiety, irritability;
• characteristic pallor of the skin (especially the face);
• alopecia (baldness);
• sphincter weakness (urinary and fecal incontinence);
• increased swelling of the limbs and face.

Why does a person need iron and what forms of this element exist in pharmacology?

In our body, the average indicator of the presence of iron is 3.5-4.5 g. Of this amount, approximately two-thirds are located in the blood, one-third is stored in the liver, muscle tissue, and spleen.

Iron is necessary for humans, since when it is deficient, the following processes are disrupted:

• cholesterol metabolism;
• liver function;
• hematopoiesis;
• hemoglobin synthesis;
• functioning of the immune system;
• various redox reactions;
• thyroid function.

It would not be an exaggeration to say that every process in the human body occurs to one degree or another through the influence of ferritin.

Not all iron from preparations is equally useful: very often the trivalent form is simply not absorbed and leaves the body along with feces. The instructions for use for Sorbifer Durules indicate that it contains a ferrous iron compound, which is better absorbed. In addition, in the manufacture of capsules, a special technology is used that allows the molecules of the element to be released gradually as they move through the gastrointestinal tract. This fact sets this iron preparation apart from all others.

Composition of the drug "Sorbifer Durules"

The drug is a large tablet in a special coating, which dissolves slowly and only under the influence of special enzymes. This technology allows iron to be completely absorbed by the body and bring maximum benefit to the patient. The release of element ions occurs for a total of six to seven hours after taking the tablet. This is the essence of the Durules technology: the name of the drug consists of two words, and the second is precisely the patented principle of slow absorption.

"Sorbifer Durules" after a meal may be absorbed a little slower than when taken on an empty stomach (the difference is about two hours).

The drug is sold in thick glass bottles, each containing 30 or 50 tablets.

Composition of one tablet:

• iron sulfate - 320 milligrams;
• ascorbic acid - 60 milligrams.

Manufacturers have enriched the composition of the drug with ascorbic acid (or vitamin C) for a reason. This component increases the absorption of iron. Thanks to the Durules technology and ascorbic acid in the composition, it was possible to achieve almost one hundred percent digestibility of ferrum.

Cost, where to buy

The drug can be purchased at any pharmacy without a doctor's prescription. The cost of a bottle with 30 tablets is about four hundred rubles, 50 tablets will cost 600 rubles. Depending on the region (place of purchase) and the markup of the pharmacy chain, the cost may vary. The packaging includes a cardboard box containing a glass bottle of tablets and instructions.

The price of Sorbifer Durules and its effectiveness make the drug popular among a wide variety of categories of patients. Many people buy it after reading rave reviews about its effectiveness. Some patients are given a prescription for purchase by neurologists and endocrinologists.

Indications for use

Instructions for use of "Sorbifer Durules" (the price can be found above) states that the drug is active in the following conditions and pathologies:

• prolonged bleeding of various nature (uterine, after surgery or wounds, and so on);
• Iron-deficiency anemia;
• intentional or unintentional fasting;
• impaired absorption of iron from food;
• malignant alopecia.

The drug is effective only for anemia caused by a lack or impaired absorption of ferritin (iron). If the causes of anemia are different, Sorbifer Durules is useless. How to take the drug so that it provides maximum benefit to the body will be described below.

Side effects

The drug quite often causes the following side effects:

• from the nervous system: insomnia, vigor, motor activity, nervous tics (rarely);
• from the gastrointestinal tract: diarrhea, prolonged diarrhea, black stool;
• from the endocrine system: loss of appetite, weight loss, fats may not be partially absorbed (rarely);
• Quite rarely, the drug can provoke ulceration and narrowing of the esophagus.

How to take Sorbifer Durules to avoid side effects? You should start taking it with the minimum daily dose. If the patient weighs less than forty kilograms and has diagnosed iron deficiency anemia of the third degree, you can start taking half a tablet (despite the fact that cutting the tablet is not recommended so as not to disrupt the integrity of the shell).

Contraindications for use

The drug has a number of contraindications:

• hemosiderosis;
• hemochromatosis;
• aplastic and hemolytic anemia;
• sideroblastic anemia;
• age up to twelve years;
• pathologies of the esophagus (iron can aggravate them).

Also, use is prohibited for certain diseases of the gastrointestinal tract. Often, before prescribing medications with iron, doctors play it safe and refer the patient for a full examination to a gastroenterologist. This is done in order to avoid problems with the esophagus and stomach. Iron supplements can aggravate the course of erosion and ulcerative diseases of the esophagus, stomach, and intestines.

Drug interactions

With the simultaneous administration of Sorbifer Durules and tetracycline antibiotics, there is a significant decrease in the absorption of both drugs. Concomitant use of these drugs is not recommended.

Antacids (medicines with magnesium, aluminum, calcium) significantly reduce the absorption of iron ions.

The use of Sorbifer Durules reduces the absorption of Enoxacin, Methyldopa, Levofloxacin, Clodronate (and all drugs containing their metabolites), thyroid-stimulating hormones. If it is absolutely necessary to combine these drugs, you should wait at least three hours between taking therapeutic doses. The absorption of the drug is negatively affected by Chloramphenicol and oral contraceptives, as well as some foods and drinks (milk, eggs, tea, coffee, juices, bread).

The tablet should be taken whole without chewing. Drink with clean, cool water.

How should you use Sorbifer Durules: before meals or after? The opinion of doctors and the information from the instructions are unanimous: the tablet should be taken twenty to thirty minutes before meals. In rare cases, when taking it on an empty stomach causes severe nausea and vomiting, you can take the tablet immediately after eating. This intake will not reduce the effectiveness of the drug, but it may take longer to absorb iron.

One or two tablets should be taken per day, the amount depends on the hemoglobin and ferritin levels in the patient’s blood. If iron deficiency anemia is clearly expressed, you should take two tablets; after one or two months, as the patient’s condition improves, switch to a dosage of one tablet per day.

"Sorbifer Durules" during pregnancy: benefit or harm

The state of pregnancy imposes strict limits and restrictions on the list of medications taken. Alas, in an interesting situation, iron deficiency anemia most often develops and hemoglobin and ferritin levels decrease. The growing fetus takes a lot of vitamins and microelements for itself, which is why a deficiency of one or another substance often develops.

"Sorbifer Durules" is used during pregnancy in the absence of contraindications. As a rule, the patient is prescribed one tablet per day, twenty to thirty minutes before meals. Most often, hemoglobin levels increase significantly after two to three weeks from the start of therapy.

Self-medication can be harmful to your health.
You should consult your doctor and read the instructions before use.

Sorbifer Durules: instructions for use

Compound

Each tablet contains ferrous sulfate in an amount of 320 mg, equivalent to 100 mg Fe 2+, and 60 mg ascorbic acid.

The tablets also contain inactive components: povidone, polyethylene powder, carbomer 934 R, magnesium stearate, solid paraffin, hypromellose, macrogol 6000, titanium dioxide, yellow iron oxide.

Description

lenticular slightly biconvex, ocher-yellow film-coated tablets, engraved “Z” on one side, with a characteristic odor.

pharmachologic effect

Pharmacotherapeutic group: Antianemic drugs. Iron preparations (ferrous) for oral administration.

Indications for use

Iron-deficiency anemia. Iron deficiency. Prophylactic use during pregnancy.

Contraindications

Hypersensitivity to the active or any of the inactive ingredients of the drug. Esophageal stenosis and/or obstructive changes in the digestive tract. Hemosiderosis, hemochromatosis. Sideroachrestic anemia, anemia due to lead poisoning and other types of anemia not caused by iron deficiency in the body (aplastic and hemolytic). Repeated blood transfusions. The drug is not intended for the treatment of children under 12 years of age.

Pregnancy and lactation

Sorbifer Durules can be used during pregnancy and breastfeeding.

Directions for use and doses

The tablet should be swallowed whole and washed down with at least half a glass of liquid. The tablet must not be split or chewed. Iron absorption improves when taking the drug within half an hour before meals. However, in cases of dyspeptic symptoms, to reduce their severity, the drug can also be taken during meals or after meals. Iron tablets should not be given to a patient in a horizontal position.

Adults and teenagers over 12 years old:

Usually prescribed 1 tablet in the morning and evening.

If necessary, due to the occurrence side effects, the dose can be reduced by half, to 1 tablet per day.

For patients with iron deficiency anemia, the dose can be increased, if necessary, to 3-4 tablets per day in two doses (morning and evening).

The duration of treatment is determined individually based on iron metabolism. After reaching the optimal hemoglobin level, you should continue taking the drug for about two more months to replenish iron reserves. Thus, the total duration of therapy for severe iron deficiency can be from 3 to 6 months.

Side effect

The incidence of side effects from the gastrointestinal tract increases with increasing doses and is 7-20% at doses from 100 to 400 mg per day.

Frequent (>1/100): Gastrointestinal: nausea, abdominal pain, diarrhea, constipation.

Rare (<1/100): Gastrointestinal: ulcerative lesions of the esophagus, stenosis of the esophagus.

From the skin: Rash.

Overdose

Symptoms: Abdominal pain, vomiting and diarrhea (sometimes bloody), dehydration, acidosis, drowsiness and shock. The patient's condition may improve, but after an asymptomatic period of 6-24 hours, symptoms may recur: coagulopathy, cardiovascular collapse (heart failure due to myocardial damage), hyperthermia, hypoglycemia, liver damage, renal failure, muscle cramps and coma. In the future, liver cirrhosis and pyloric stenosis may develop. Septicemia caused by Yersinia enterocolitica. Risk of intestinal perforation.

Treatment: As an emergency measure, take milk and raw eggs to form an iron-protein complex and induce vomiting (as soon as possible). Then do a gastric lavage with a 1% solution of sodium bicarbonate to form a sparingly soluble iron compound. Deferoxamine is a specific antidote.

In case of overdose, contact your doctor or the nearest hospital emergency room immediately. Take these instructions and any remaining tablets with you to show your doctor.

Interaction with other drugs

Sorbifer Durules reduces the absorption of concomitantly used enoxacin, ciprofloxacin, moxifloxacin, norfloxacin, ofloxacin, levofloxacin.

The simultaneous administration of drugs from the fluoroquinolone group with the drug Sorbifer Durules is not indicated due to a decrease in the absorption of quinolones below the therapeutic level.

Sorbifer Durules reduces the absorption of simultaneously used bisphosphonates, levodopa, methyldopa, tetracyclines, captopril, zinc salts and thyroid hormones, which can lead to a clinically significant decrease in their effectiveness.

The simultaneous administration of penicillamine or desferroxamine with the drug Sorbifer Durules leads to a decrease in the absorption of these drugs.

Concomitant use of Sorbifer Durules with medications to reduce gastric acidity or dietary supplements containing aluminum hydroxide, magnesium carbonate or calcium carbonate may reduce iron absorption. Reduced stomach acid production when taking cimetidine also reduces iron absorption.

The maximum possible time interval should be maintained between taking Sorbifer Durules and any of the drugs listed above. The recommended minimum interval between doses is 2 hours, except in cases of concomitant use of tetracyclines, when the interval should be at least 3 hours.

Concomitant use of chloramphenicol may delay the development of the effects of iron therapy.

Egis JSC pharmaceutical plant Egis Pharmaceutical plant JSC Egis Pharmaceutical plant JSC

Country of origin

Hungary

Product group

Blood and circulation

Antianemic drug

Release forms

• 30 - dark glass bottles (1) - cardboard packs. 50 - dark glass bottles (1) - cardboard packs.

Description of the dosage form

• round, biconvex, light yellow film-coated tablets, engraved with “Z” on one side, with a core on the break gray with a characteristic odor Light yellow film-coated tablets, round, biconvex, engraved “Z” on one side; at the break - a gray kernel with a characteristic odor

pharmachologic effect

Iron is an essential component of the body, necessary for the formation of hemoglobin and the occurrence of oxidative processes in living tissues. The drug is used to eliminate iron deficiency. Durules technology provides a gradual release of the active ingredient (iron ions) over a long period of time. The plastic matrix of Sorbifer Durules tablets is completely inert in the digestive juice, but completely disintegrates under the action of intestinal peristalsis, when the active ingredient is completely released.

Pharmacokinetics

Durules is a technology that provides gradual release active substance(iron ions), uniform supply of the drug. Taking 100 mg twice a day provides 30% greater absorption of iron from Sorbifer Durules compared to conventional iron supplements. Absorption and bioavailability of iron are high. Iron is absorbed primarily in the duodenum and proximal jejunum. Connection with plasma proteins - 90% or more. Deposited in the form of ferritin or hemosiderin in hepatocytes and cells of the phagocytic macrophage system, a small amount - in the form of myoglobia in muscles. The half-life is 6 hours.

Special conditions

Darkening of the stool is possible, which has no clinical significance. Pregnancy and lactation Sorbifer Durules can be used during pregnancy and breastfeeding. OVERDOSE Symptoms: abdominal pain, vomiting and diarrhea mixed with blood, fatigue or weakness, hyperthermia, parasthesia, pale skin, cold clammy sweat, acidosis, weak pulse, decreased blood pressure, palpitations. In severe overdose, signs of peripheral circulatory collapse, coagulopathy, hyperthermia, hypoglycemia, liver damage, renal failure, muscle cramps and coma may appear after 6-12 hours. Treatment: in case of overdose, consult a doctor immediately. It is necessary to rinse the stomach, inside a raw egg, milk (to bind iron ions in the gastrointestinal tract); deferoxamine is administered. Symptomatic therapy.

Compound

• Each film-coated tablet contains ferrous sulfate in an amount equivalent to 100 mg Fe2+ and 60 mg ascorbic acid, as well as: magnesium stearate, povidone K-25, polyethylene powder, carbomer 934P. The shell contains: hypromellose, macrogol 6000, titanium dioxide, yellow iron oxide, solid paraffin

Sorbifer Durules indications for use

• - treatment of iron deficiency anemia (with insufficient intake of iron into the body from food, with an increased need for iron in the body; with chronic blood loss); - prevention of iron deficiency anemia (including during pregnancy and lactation, in women of childbearing age, in children and adolescents during periods of intensive growth, in the elderly).

Sorbifer Durules contraindications

• - narrowing of the esophagus and/or other obstructive gastrointestinal diseases; - pathological conditions caused by increased deposition of iron in the body; - children under 12 years of age; - increased sensitivity to the drug

Sorbifer Durules side effects

• From the digestive system: mild nausea, epigastric pain, diarrhea or constipation.

Drug interactions

Durules may reduce the absorption of concomitantly administered enoxacin, clodronate, grepafloxacin, levodopa, levofloxacin, methyldopa, penicillamine, tetracyclines and thyroid hormones. The simultaneous use of Sorbifer Durules and antacid preparations containing aluminum hydroxide and magnesium carbonate may reduce the absorption of iron. The maximum possible time interval should be maintained between taking Sorbifer Durules and any of these drugs. The recommended minimum time interval between doses is 2 hours, except when taking tetracyclines, where the minimum interval should be 3 hours. Sorbifer Durules should not be combined with the following drugs: ciprofloxacin, doxycycline, norfloxacin and ofloxacin

Storage conditions

• store at room temperature 15-25 degrees
• keep away from children

Information provided

In this article you can read the instructions for use of the drug Sorbifer Durules. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Sorbifer Durules in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Sorbifer Durules in the presence of existing structural analogues. Use for the treatment of iron deficiency in the body, anemia and increasing hemoglobin levels in adults, children, as well as during pregnancy and lactation.

Sorbifer Durules- antianemic drug. Iron is an essential component of the body, necessary for the formation of hemoglobin and the occurrence of oxidative processes in living tissues.

Durules technology provides a gradual release of the active ingredient (iron ions) over a long period of time. The plastic matrix of Sorbifer Durules tablets is completely inert in the digestive juice, but completely disintegrates under the action of intestinal peristalsis, when the active ingredient is completely released.

Ascorbic acid helps improve iron absorption.

Compound

Iron sulfate + Ascorbic acid (vitamin C) + excipients.

Pharmacokinetics

Durules is a technology that ensures a gradual release of the active substance (iron ions) and a uniform supply of the drug. Taking 100 mg 2 times a day provides 30% greater absorption of iron from Sorbifer Durules compared to conventional iron preparations. Absorption and bioavailability of iron are high. Iron is absorbed primarily in the duodenum and proximal jejunum. Plasma protein binding - 90% or more. Deposited in the form of ferritin or hemosiderin in hepatocytes and cells of the phagocytic macrophage system, a small amount - in the form of myoglobin in muscles.

Indications

• Iron-deficiency anemia;
• iron deficiency;
• prevention of iron deficiency anemia during pregnancy, lactation, and in blood donors.

Release forms

Film-coated tablets.

Instructions for use and dosage regimen

The drug is taken orally. Film-coated tablets should not be split or chewed. The tablet should be swallowed whole and washed down with at least half a glass of liquid.

Adults and adolescents are prescribed 1 tablet 1-2 times a day. If necessary, for patients with iron deficiency anemia, the dose can be increased to 3-4 tablets per day in 2 doses (morning and evening) for 3-4 months (until the iron depot in the body is replenished).

During pregnancy and lactation, for the purpose of prevention, 1 tablet per day is prescribed; For treatment, 1 tablet is prescribed 2 times a day (morning and evening).

Treatment should be continued until the optimal hemoglobin level is achieved. To further replenish the depot, you may need to continue taking the drug for another 2 months.

Side effect

• nausea, vomiting;
• stomach ache;
• diarrhea;
• constipation;
• ulcerative lesions of the esophagus;
• esophageal stenosis;
• rash;
• headache;
• dizziness;
• skin hyperthermia;
• weakness.

Contraindications

• esophageal stenosis and/or other obstructive changes in the digestive tract;
• increased iron content in the body (hemosiderosis, hemochromatosis);
• impaired iron utilization (lead anemia, sideroblastic anemia, hemolytic anemia);
• children under 12 years of age (due to lack of clinical data);
• hypersensitivity to the components of the drug.

Use during pregnancy and breastfeeding

It is possible to use the drug Sorbifer Durules during pregnancy and lactation according to indications.

Use in children

The drug is contraindicated in children and adolescents under 12 years of age.

special instructions

When using the drug, darkening of the stool (black stool) is possible, which has no clinical significance.

The drug should be used with caution in case of gastric ulcer and duodenum, inflammatory diseases intestines (enteritis, diverticulitis, ulcerative colitis, Crohn's disease).

Drug interactions

Sorbifer Durules may reduce the absorption of concomitantly administered enoxacin, clodronate, grepafloxacin, levodopa, levofloxacin, methyldopa, penicillamine, tetracyclines and thyroid hormones.

The simultaneous use of Sorbifer Durules and antacid preparations containing aluminum hydroxide and magnesium carbonate may reduce the absorption of iron. The maximum possible time interval should be maintained between taking Sorbifer Durules and any of these drugs. The recommended minimum time interval between doses is 2 hours, except when taking tetracyclines, when the minimum interval should be 3 hours.

Sorbifer Durules should not be combined with the following drugs: ciprofloxacin, doxycycline, norfloxacin and ofloxacin.

Analogues of the drug Sorbifer Durules

Structural analogues of the active substance:

• Fenyuls 100;
• Ferroplex.

Analogs by pharmacological group (drugs for the treatment of iron deficiency):

• Actiferrin compositum;
• Aloe syrup with iron;
• Biovital elixir;
• Biofer;
• Venofer;
• Vitrum Superstress;
• Vitrum Circus;
• Hemofer;
• Gyno Tardiferon;
• Likferr 100;
• Maltofer;
• Maltofer Fall;
• Multi tabs Active;
• Pikovit Complex;
• Merz special dragee;
• Stress formula with iron;
• Supradin Kids Junior;
• Tardiferon;
• Totema;
• Ferlatum;
• Ferretab;
• Ferrinate;
• Ferro Folgamma;
• Ferrogrademet;
• Ferronal;
• Ferronal 35;
• Ferrum Lek;
• Heferol;
• Enfamil Premium 2;
• Enfamil with iron.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.