Paracetamol tablets for children: instructions for use and dosage for different ages. Is it possible to give paracetamol tablets to children? Dose for different dosages of the active substance Paracetamol dosage for children

A children's first aid kit is a must-have in every home where there is a baby. The most accessible and common analgesic and antipyretic drug, approved from a very early age, is paracetamol. This is a salvation both in case of high fever and pain of various origins.

It is commercially available in the form of suppositories, sweet syrup, and tablets. It is quickly absorbed, begins to act within 30-40 minutes after consumption, has a minimum of contraindications, and is prescribed to children whose hyperthermia is accompanied by convulsions.

The listed arguments are often decisive when purchasing, however Parents should consider the following nuances:

• up to 5 years of age in the treatment of children it is better to use suppositories, syrups, suspensions;
• strict adherence to dosage proportions is required in order not to expose the body weakened by the disease to the risk of unnecessary intoxication.

In this material we will analyze in detail what dosage at temperature is possible for children of different ages, and how to give it correctly. This form of the drug raises the most questions. Basic:

• at what age is it allowed, dosage;
• how to divide a pill into parts;
• admission rules;
• what to do in case of overdose.

We will look at them:

Is it possible to give paracetamol tablets to children?

Memo to parents: The numbers embossed on the tablets indicate the content of the active substance - paracetamol - in milligrams, sometimes in grams. They are written on the blister.

Existing options: 200 (0.2), 325 (0.325), 500 (0.5). This makes it easier to determine the norm in the number of pieces.

The first thing to remember is that this form not used in treatment at all. The instructions indicate - with, pediatricians recommend with 5.

It is better to crush the pill or part of it into powder, dilute it with a lukewarm liquid (sweetened water, compote, tea). It is advisable to tie it to a meal: give the medicine after an hour or two.

Experiments to create mixtures of the drug in question with No-shpa, analgin and other medications are strictly prohibited.

Contraindications:

• individual intolerance to the main substance;
• liver or kidney dysfunction;
• blood diseases.

Paracetamol for children: dosage in tablets at fever

Paracetamol 200 mg

This dosage is the most convenient, since the calculation is carried out in a multiple of 100.

Regulated normal from 3 to 6– 150-200 mg. Pediatricians, without further ado, prescribe one tablet at a time. For skinny kids, half is enough. The permissible maximum is 800 mg/day (no more than 4 pieces).

For older kids ( from 6 years of age) the norm is increased to 1.5-2.

If the fever does not subside, the medicine is given again. The minimum interval between doses is 4 hours.

It is strictly forbidden to use this product in parallel with other drugs containing paracetamol. If you give a pill and the fever does not subside, use other non-drug methods:

• ventilate the room;
• give your baby some water;
• apply lotions (on the forehead, armpits, groin area).

Paracetamol 325 mg

This option designed for children 6-12 years old. One full pill is given at a time. There is no need to divide or add anything. Can be crushed into powder.

The frequency of administration is similar to that indicated above.

Mothers who strictly follow the rules are interested in How to accurately calculate the dose of paracetamol for children?

Medical response: take 10-15 mg per kilogram of body weight. For example, for 2 years old the weight norm is 11.5 kg. Hence, ≤ 172.5 mg is required. It is simply impossible to separate the required amount from the tablet. But there are suitable suppositories containing 170 mg of antipyretic substance.

Dosage of 500 mg tablets

This packaging is considered “adult”. For teenagers from 12 years old given as a single tablet.

You should not expect positive results immediately after using the drug. The temperature drops after about 30 minutes to an hour, usually to 37-37.5°.

The use of this medicine for more than 3 days without a doctor's permission is not allowed.

Attention, paracetamol overdose in children, what to do in such a situation?

Anxiety symptoms: arrhythmia, pallor, vomiting or severe nausea, abdominal pain. An acute attack of pancreatitis cannot be ruled out. Usually these signs are noticeable almost immediately, but may appear within 24 hours after ingestion. In severe poisoning, liver failure progresses to hemorrhage and loss of consciousness. Kidney dysfunction is indicated by unbearable pain in the lower back and blood in the urine.

Urgent hospitalization is required.

If no more than an hour has passed since taking the drug, you can give activated charcoal yourself, but still take the baby to the hospital.

Remember the main thing:

• You cannot reduce fever with the “strongest” means; you must use only approved drugs and in a suitable form;
• the temperature is not brought down to 38.5°, the body must fight on its own;
• Do not risk the health of your children; even a one-time increase in dose is fraught with irreversible consequences.

With the development of colds, the first sign in children is an increase in temperature. If pediatricians prohibit giving children antipyretics at elevated temperatures, then if the thermometer readings are above 39 degrees, you should definitely resort to medication. One of the most effective ways to reduce high fever is a medication called Paracetamol. Is it possible to give children Paracetamol in tablets, at what age should it be used, as well as the specific dosage of the drug, we will find out further.

Dosage of Paracetamol tablets

Paracetamol for fever is available in three forms: tablets, syrup and rectal suppositories. All forms of the drug are intended to reduce high fever. Paracetamol in certain dosage forms should be given to a child depending on his age.

The main advantage of the drug in tablet form is its low cost, especially when compared with syrups. Many parents resort to medication in tablets only when the child turns 5 years old. It is at this age that a baby can swallow a pill without it getting stuck in the throat. Some parents are in no hurry to resort to using the drug in tablets, and give it from the age of 6.

The instructions for use indicate that children can be given the drug in tablet form at 2 years of age and older. However, it is important to note that at 2-3 years of age it is preferable to give syrup to babies, and before 2 years of age it is best to use rectal suppositories. It is possible for young children to take Paracetamol in tablet form if they have a fever, but the tablet should initially be crushed and then given to drink with sweetened water.

It is important to know! At high temperatures, children can be given Paracetamol no more than 4 times a day. The break between subsequent doses should be 4-6 hours. The duration of therapy should not be more than 3 days.

How to give Paracetamol tablets to children depends on their age and weight. Paracetamol for children with fever should be calculated based on the following dosage: per 1 kg of baby’s body weight, 10 mg of the drug is required. For a baby whose weight is 10 kg, 100 mg of the drug will be required.

Interesting to know! The drug allows you to bring down the temperature in a child about 25-30 minutes after ingestion.

Dosage of Paracetamol 200 mg in tablet form

We have already found out whether Paracetamol can be given to children. It is only worth noting that if a child at the age of 5-6 cannot swallow the tablet whole, it should be divided into parts or crushed into powder. Giving infants a remedy in the form of tablets is not recommended, so it is better to resort to rectal suppositories.

The drug Paracetamol 200 mg is very popular. Tablets are quickly absorbed by the body, so after 30 minutes there is a positive effect from its use. In addition, the tablets do not contain flavors and dyes that can harm the baby when taken orally. You can not only bring down the temperature with the drug, but also reduce pain symptoms from toothaches, headaches, neuralgia and osteochondrosis. Let’s find out in more detail how to lower the temperature with the help of the medicine in question.

• It is not recommended to give antipyretic tablets to children under two or three years of age. Moreover, if the doctor has prescribed the use of the drug for the baby in this form, then you can resort to such treatment.
• Children under the age of five or six years can be given the medicine in tablet form, but only at a dosage of 100 mg. Paracetamol can be given to a child at this age no more than 2 times a day.
• Children under 12 years of age are given the drug at a dosage of 200 mg. The dosage of Paracetamol depends primarily on weight, so before giving the medicine to your baby, you need to read the instructions.
• Older children from 12 years of age can be given Paracetamol at a dosage of 500 mg.

The instructions indicate that children under 12 years of age can be given tablets with a dosage of 500 mg, but the dose must be calculated correctly. It is also important to note the fact that before giving medicine at a temperature of 38 and above, you should consult a specialist. Your local or attending physician will tell you how to take it, how much of the drug you need, and how often you can take it.

It is important to know! You need to lower your baby’s temperature if the thermometer shows above 39 degrees. An adult can begin to reduce the fever if the mark exceeds 39-39.5 degrees.

Can children take medicine in tablets?

Doctors say that children can take pills if certain conditions are met.

1. If the thermometer reading is above 38.5-39 degrees. For children under 3-4 years old, it is necessary to reduce the fever above 38-38.5 degrees.
2. There is no need to rush to bring the fever down below 38. If the thermometer readings are above 38, you should initially try to use the folk method, for example, wiping with vinegar solution. If the fever continues to rise or lasts four hours or more after the parents have taken all the methods to reduce it, then this medicine can be given.
3. Is it possible for a child to take Paracetamol, and in what dosage should it be used for high fever, toothache and weakness. It can not only be given, but it is also necessary. If the drug did not bring down the fever, but at the same time the pain during teething decreased, then it is necessary to consult a specialist or replace the medicine with Ibuprofen.

Paracetamol is an excellent tool in the fight against high fever in children of all ages. With age, the form of the drug can be changed, and the name of the drug can remain the same, but on one condition that the drug gives a positive effect.

Is it dangerous to overdose on a medicine?

The instructions indicate that in case of an overdose of the drug you should consult a doctor. We found out how to give Paracetamol to children, but why is an overdose of this drug so dangerous? In fact, Paracetamol is one of the safest antipyretic drugs. In case of a slight overdose, this will not affect the baby’s health in any way, especially if the medicine is used in a single dosage.

It is important to know! Before using Paracetamol in tablets for children with fever, you should familiarize yourself with the dosage of the medicine, and then select it according to the baby’s weight.

Is it possible to give a child paracetamol in tablets, what should be the dosage, are there any contraindications for use? Here's what we'll look at today...

Can I have paracetamol, how does it work?

Paracetamol is an effective antipyretic and analgesic effect; its mechanism of action is based on the suppression of the biosynthesis of prostaglandins, which are mediators of the transmission of electrical impulses in the central nervous system.

Suppression of electrical activity in nervous tissue mainly occurs in the centers of thermoregulation and pain located in the hypothalamus. The drug has almost no effect on other nerve formations.

In addition, this drug does not have an anti-inflammatory effect due to complete destruction in peripheral tissues due to the activity of peroxidases (special enzymatic complexes).

Another important circumstance is associated with destruction in peripheral tissues: paracetamol almost does not cause side effects typical for this group of drugs, namely, damage to the intestinal mucosa, the likelihood of which increases sharply with long-term use.

The use of paracetamol, regardless of the dosage form, helps to quickly suppress the symptoms of febrile syndrome: elevated body temperature, headache, malaise, and so on.

Can children use paracetamol or what is its use in pediatric practice?

It should be noted that all pediatricians are divided into two camps. Representatives of the first claim that paracetamol, especially tablets, is absolutely contraindicated under the age of 7 years. Others presented reasonable arguments proving the effectiveness and safety of such treatment. Alas, to this day there is no clear opinion on this issue.

However, early age is not a stated contraindication for use. Manufacturers of paracetamol consider the age factor to be a relative contraindication, which means that the decision on the possibility of such treatment should be made by the attending physician, guided by the severity of the condition and other factors.

The reason for this division lies in the peculiarities of the process of metabolization of paracetamol in the human body. When biological degradation reactions occur, several intermediate substances are formed that have virtually no pharmacological activity, but at the same time are very toxic.

These components are further metabolized through interaction with glutathione, which leads to a complete loss of pharmacological activity of paracetamol degradation products and their neutralization.

With glutathione deficiency, the above-mentioned metabolites can fully manifest their chemical properties, which leads to damage to the liver tissue, with the formation of necrosis and severe liver damage.

Dosage of paracetamol tablets

So, if a specialist decides to use this drug in children with fever, most likely the dosage and frequency of use will be as follows:

From birth to 3 months - 10 milligrams per kilogram of the patient’s weight 2 to 4 times a day.
From the age of 3 months to one year - in a daily dosage of 60 to 12 milligrams up to 6 times a day.
From one year to 5 years - from 120 to 160 milligrams per day for 4 doses;
From 5 to 12 years - from 250 to 500 mg per day up to 4 doses.

Of course, the dosages given above are not a guide to action and are indicated for informational purposes only. The choice of dosage is the burden of the specialist, who, guided by objective and subjective criteria, must select an effective and safe dosage.

It is important to understand that paracetamol is a drug, the unreasonable use of which can lead to irreversible and fatal consequences. You should not take this medicine thoughtlessly; only the attending physician has grounds for prescribing the drug.

In addition, parents should know a few simple recommendations. You should not, in horror, grab Paracetamol when you have a fever and knock it down.
It is generally accepted that the use of antipyretic drugs in uncomplicated cases is justified for fevers above 38 degrees. Some experts believe even higher - 38.5 degrees.

The duration of use of paracetamol as an antipyretic should not exceed 3 days. Longer treatment may be dangerous because it increases the risk of developing liver damage.

At an early age (up to 7 years), if possible, they try to prescribe other dosage forms, in particular: syrup, rectal suppositories, suspensions. Since they are safer, their use is justified.

The simultaneous use of two or more dosage forms of the drug is absolutely not applicable. With such a thoughtless approach, the likelihood of an overdose increases exponentially.

Conclusion

I remind you that the use of paracetamol must be approved by your doctor. Self-medication is not only dangerous, it can irreversibly undermine the child’s health.

The combined use of several dosage forms of the drug is unacceptable. If you want to have a complex effect on the body, you can resort to other, non-drug means: frequent ventilation of the room, drinking plenty of fluids, cool lotions on the forehead and armpits.

Paracetamol is given to a child for high fever, headache and toothache. It is considered a safe medicine, since even with a three-fold overdose it does not cause complications. However, like any medicine, Paracetamol has its own specifics, and must be treated with caution. Before treatment, you should carefully study the instructions for use of Paracetamol, paying special attention to the calculation of the dosage of tablets for children 1 year and older.

Composition and release forms of the drug

Paracetamol for children is an antipyretic and analgesic with a slight anti-inflammatory effect. Its effectiveness is especially high for viral infectious diseases; for bacterial diseases it helps little.

The therapeutic effect of the drug is based on inhibition of the production of chemical compounds that are responsible for the development of inflammatory processes, stimulate an increase in temperature and the appearance of pain. The analgesic and anti-inflammatory effect is achieved due to the effect of the drug on the cells of the central nervous system.

The advantage of the drug over other anti-inflammatory drugs is that it does not have a particular irritating effect on the gastric mucosa. Paracetamol quickly enters the blood, where its highest concentration is achieved in the period from 30 minutes to one and a half hours - depending on the form of the drug. The drug is excreted from the body along with urine after processing in the liver within 4 hours.

The active substance of the drug bears the same name, it is also known as para-acetaminophenol. For children, Paracetamol is produced in different forms:

• Candles - they contain components that are safest for the child. The drug administered rectally is absorbed into the blood more slowly than when swallowed (an hour and a half), which is why the effect occurs later, but it is longer lasting. Doctors can prescribe suppositories for the treatment of a one-year-old child and even an infant from 3 months.
• Suspension – excipients include glycerol, sorbitol, flavorings and sucrose. Can be used from 1 month (only as directed by your pediatrician).

• Syrup – contains ethanol (96%), excipients, flavorings, dyes. The maximum concentration in the blood is observed half an hour after ingestion. The product is recommended for ages from six months to 12 years.
• Tablets or capsules – available in dosages of 200 and 500 mg. Children can be given from 3 years of age (subject to the dosage).
• Effervescent tablets for preparing a solution.

Recently, Paracetamol, produced in the form of sweet syrups and suspensions, has gained particular popularity. By taking these drugs, along with active medicinal ingredients, the baby receives a huge amount of flavorings, sweeteners, and flavoring additives. They can provoke allergic reactions, while allergies to Paracetamol itself are very rare. This means that the ideal option for small children is candles.

Indications for taking Paracetamol tablets (200 and 500 mg)

Paracetamol is effective for:

• temperature caused by colds, flu, scarlet fever, measles, vaccinations, etc.;
• headaches, including those caused by overexertion;
• toothache (caries, teething, etc. (which of the drugs can be given to a child with a toothache?). D.);
• pain manifestations not associated with inflammation;
• relief of symptoms of colds or flu such as fever, aches;
• inflammation of the middle ear (otitis) as a complex therapy.

Paracetamol is used as an antipyretic and analgesic. When is the drug contraindicated?

Like any medicine, Paracetamol has contraindications. These include:

• allergy to the components of the drug;
• serious problems with the kidneys and liver, which are involved in processing and removing drugs from the body in urine;
• congenital hyperbilirubinemia, or Gilbert's syndrome - an elevated level of bilirubin in the blood (a breakdown product of red blood cells);
• some types of severe infections (for example, sepsis);
• leukopenia (low white blood cell count);
• blood diseases;
• deficiency of the enzyme glucose-6-phosphate dehydrogenase;
• severe anemia;
• taking certain drugs (anticonvulsants, barbiturates, rifampicin, etc.);
• inflammation of the rectal mucosa (for the use of suppositories).

Instructions for use of tablets

Although Paracetamol is effective in relieving fever and headaches, if you have a serious illness, it will not reduce the temperature.

Dr. Komarovsky calls this medicine a kind of marker: if the fever has decreased after taking it, there is a high probability that the disease is not dangerous - it is a common ARVI. If there is no effect from the drug, the problem is serious, you should urgently call a specialist.

Dosage for children of different ages

Paracetamol tablets are allowed for children over three years of age. For adults, the maximum daily dose is 60 mg/kg. In what dosage is Paracetamol given to children:

• norm from 3 to 6 years – 100-200 mg at a time;
• from 6 to 12 years - 1-2 tab. (200-400 mg);
• adolescents and adults – 500 mg.

Before giving your baby a tablet, you should read the instructions and find out how much paracetamol it contains. If the doctor has prescribed a dose of 100 mg, the 200 mg capsule should be divided into 2 parts, the tablet containing 500 mg should be divided into 5 parts. A slight overdose is not dangerous.

How many times a day can you take the drug?

According to the instructions, children should drink Paracetamol every 4 hours. More frequent use is not recommended, since there will be no better effect from increasing the dose multiplicity. Paracetamol is absorbed into the blood 30 minutes after entering the stomach and begins to act actively. The maximum concentration and positive effect are achieved after 2 hours - the temperature begins to decrease.

It is recommended to take the drug every 4 hours; less often yes, more often no

As soon as Paracetamol enters the child's blood, the kidneys and liver begin to process it and remove it from the body. After 4 hours, 50% of the substance leaves the body, which leads to a decrease in the effect of the drug. The medicine is completely eliminated after 8 hours. As you recover, the need for frequent medication administration disappears, so the interval can be increased to 5-6 hours.

Duration of treatment

The doctor should tell you how long the course of treatment with Paracetamol will last. At high temperatures, the product can be taken for no more than 3-5 days. Whether it is worth continuing to use the drug and what dose is prescribed per day is determined by the doctor. Irrational use of the drug can cause necrosis of liver cells, kidneys and other problems.

Long-term use of Paracetamol for headaches and toothaches is not advisable, since it can relieve symptoms, but not cure the underlying disease. Diseased teeth should be treated as soon as possible, as they not only cause pain to the baby, but can also negatively affect the growth of permanent teeth. An unreasonable headache should alert, as it can indicate serious diseases and be a reason for further diagnosis.

Side effects

The use of Paracetamol rarely causes side effects. However, their absence cannot be completely ruled out after taking the medicine.

In some cases, the drug may cause gastrointestinal upset

They may appear:

• nausea, diarrhea, vomiting, stomach pain, dizziness;
• a decrease in the level of leukocytes, erythrocytes, platelets in the blood (extremely rare);
• liver pathologies;
• allergies;
• bronchospasm.

Overdose

The child should not take more than 60 mg of active substance per kg of body weight per day. A dosage of 150 mg/kg is toxic for a baby. This means that if a baby weighs 20 kg, he can die if he takes 3 g of paracetamol during the day.

An overdose causes side effects and signs of intoxication: pale skin, vomiting, sweating, loss of consciousness. If the liver fails, jaundice, hepatic coma, and death are possible. Acute renal failure may occur, which will make itself felt by lower back pain, pancreatitis, arrhythmia, and the appearance of protein and blood in the urine.

Analogues of the drug

Paracetamol is included in many medications - Coldrex, TeraFlu, Antigrippin, Panadol, Antiflu, Caffetin, etc. Their main differences are excipients, manufacturer, price.

If the medicine does not help, it is replaced with an analogue with another active ingredient. Medicines based on ibuprofen have a similar effect - Nurofen, Ibufen, etc. In any case, you must remember: even the most harmless medications cannot be prescribed to yourself in order to avoid unpredictable consequences.

Children aged 3 years most often suffer from acute respiratory viral infections and other infections, so elevated body temperature is very common among them. To combat this symptom, many doctors recommend using Paracetamol. How to properly give this medicine to babies, what dose should not be exceeded and what analogues can replace it?

Can it be given to a three year old child?

Paracetamol preparations are contraindicated only in the neonatal period, and are given to children 1-3 months old only if they have a temperature reaction to vaccination. In other cases, the medicine is approved from 3 months of age, so you can give Paracetamol to a 3-year-old child without fear.

Release form and mechanism of action

The drug is presented in several forms, among which the following are usually used in the treatment of children of three years:

• Rectal suppositories. They are distinguished by their white color, simple composition (except for paracetamol, in doses from 50 to 500 mg they contain only a fat base), and oblong shape. This medication helps if the child has allergies or vomiting, but it begins to show its effect later than other dosage forms, so it is often used at night.

• Suspension. This sweet preparation with orange or strawberry flavor contains paracetamol in a dose of 120 mg/5 ml, but also includes other ingredients (xanthan gum, sucrose, sorbitol, propylene glycol, etc.) that can provoke an allergic reaction. Due to the liquid structure and the presence of a measuring syringe in the package (it can be replaced with a spoon), dosing this Paracetamol is very easy, and children in most cases swallow it without problems.

• In tablet form The drug is available in 200 and 500 mg doses for adults. Children are given a solid form from the age of six, therefore, at the age of 3, the use of such Paracetamol is not recommended. However, in rare cases, when there is no other antipyretic medicine at home, part of the pill can be given to the child, after checking the dose with the doctor. If the baby still cannot swallow the medication, the tablet is crushed and diluted in a spoon with water, compote or juice.

The action of any of the forms of Paracetamol is associated with the ability of the main component of the drug to influence the centers of thermoregulation and pain in the brain. This effect is represented by the blocking of cyclooxygenase enzymes under the action of paracetamol, as a result of which the temperature returns to normal, and pain decreases.

Such effects determine the following indications for the use of Paracetamol:

• Fever (usually the drug is given at temperatures above +38.5 degrees).
• Pain syndrome of moderate or weak strength.

Features of use in childhood

It is advisable to give Paracetamol to children only after a doctor's examination, so that the use of such a medicine does not affect the determination of the correct diagnosis. In addition, this is only a symptomatic remedy, so it is usually given along with drugs that will also affect the cause of fever or pain.

The duration of treatment with Paracetamol, depending on the indications, does not exceed 3-5 days. If you need to give the medication for longer, this must be agreed with the attending physician, because long-term use can affect the hematopoiesis and the work of the internal organs of the child.

The drug can be given to the child at intervals of at least four hours. If the taken suspension or the given suppository does not bring down the temperature, use earlier than after 4 hours is unacceptable. In such situations, you need to consult a doctor and use another antipyretic drug as prescribed.

It is recommended to take the suspension an hour after meals, but if the temperature is very high, this recommendation is not taken into account (the drug is given regardless of diet). You should not dilute the medicine with water, since due to such dilution the volume of the medicine will be larger, and the child may not drink it completely. However, it is advisable to give plenty of additional fluids, as this will help fight the fever.

Contraindications to taking Paracetamol include intolerance to any of the components of the drug, liver disease, some hereditary diseases, and gastrointestinal pathologies. Before giving medication to your baby, you should find out if he has any such health problems.

Do not exceed the dose of the drug yourself, combine it with other paracetamol-based medications, or store the suspension in a place where it could be discovered and accidentally drunk by a small child. In such situations, the risk of overdose increases, which can pose a danger to the health of a small patient.

Dosage

To determine a single dose for a three-year-old child, you need to know his weight in kilograms. It is multiplied by 10-15 and the number of milligrams of paracetamol per dose is obtained. For example, the weight of a particular baby is 14 kg. Such a child requires 140-210 mg of paracetamol at a time, so treatment begins with 6 ml of suspension or 3/4 of a 250 mg suppository is given.

The average single dose of the suspension can be taken from the table, which is in the annotation. Since the weight of 3-year-old children usually ranges from 12 to 18 kg, for children weighing 12-16 kg, 5 ml of medication is taken at one time, and for children weighing 16-18 kg, a single dosage of 10 ml is required.

The daily dosage of the drug is also calculated by weight. It is known that a child should not receive more than 60 mg of paracetamol per day per kilogram of his body weight. So, a patient weighing 14 kg can be given no more than 840 mg of medication per day. If a suspension is used, then this amount of the active ingredient is in 35 ml.

What to replace it with?

If suppositories and suppositories are not available at home or in the pharmacy, you can use another medicine instead, the effect of which is also provided by paracetamol. For example, a child can be given a Cefekon D suppository or a Panadol Baby suspension. Medicines that contain ibuprofen can also replace such drugs. They are also produced for children in suppositories and suspensions, given from the age of three months and recommended for high fever or pain.

In some cases, when an increase in temperature poses a danger to the child, and Paracetamol cannot cope with the fever, they resort to a mixture of drugs called lytic. It includes an antipyretic drug (often Analgin) and an antihistamine (most often Suprastin is chosen). If the child is pale and his limbs are cool, then an antispasmodic, for example, No-shpa, is added to these two drugs.

The use of such a mixture quickly and effectively lowers the temperature and improves the child’s condition, but is not recommended without a doctor’s prescription. After checking with the pediatrician about the dosage suitable for a three-year-old child, these medications are given in tablets. If there is a need for injection, it is better to entrust the injection to the medical staff by calling an ambulance.

For information on which antipyretics to use, see the following video.

Among the popular means of combating fever and pain in children are tablets, where paracetamol acts as the active substance. It is considered the most effective and safe for the child’s body.

Paracetamol-based drugs have three main properties: they relieve fever, inflammation and pain.

Advantages of the drug:

• Fights high body temperature during colds, ARVI or flu. It can be given to children aged 2 months, after first reducing the permissible dose.
• The decrease in temperature begins quickly and has a lasting effect - its further increase is not observed.
• In some children, high fever may be accompanied by seizures. Paracetamol is also allowed for such unpleasant symptoms.
• Reduces or eliminates pain. For example, dental or headache.
• Other medications can be given at the same time. Nurofen contains ibuprofen as an active ingredient, so their alternation is allowed.

It should be borne in mind that paracetamol eliminates only the symptoms of the disease, but is not intended for its treatment. The underlying cause of pain or fever should be identified and children treated with other drugs.

Dosage of the drug

Paracetamol comes in three main forms: suppositories, tablets and syrups. You can buy a drug at a pharmacy where this active ingredient is in its pure form - Panadol, for example. Panadol tablets, in addition to the active substance, have sodium bicarbonate, which creates an alkaline environment in the body. Thanks to this, Panadol works faster.

Candles

They are inserted rectally - into the child's anus. Before the procedure, you must first wash your hands. Place the child, turn him on his side, bend his legs and press them to his tummy. Slowly and carefully introduce the suppository. The active substance is absorbed by the intestinal walls and has a rapid effect at high temperatures. For children under three months, the dosage is selected only by a doctor..

At the pharmacy you can find the following dosage of the drug:

• from 3 months to a year, 0.08 gram suppositories are prescribed;
• from 1 year to 3 years – 0.17 grams;
• from 3 years to 6 – 0.33 grams;
• starting from 6 years and older, two suppositories of 0.33 grams are prescribed.

You should not use more than 4 suppositories per day.

Pills

They are allowed for children starting from two years old. The child is given medicine, previously crushed and diluted in water. Children's paracetamol tablets are available in a dosage of 200 mg:

• from 2 to 6 years, 1/2 tablet is prescribed at a time;
• from 7 to 12 years, one full tablet is allowed;
• Children over 12 years of age are allowed to take two tablets at a time.

In some cases, this form can also be taken by children under one year of age. Especially when it comes to a very high temperature with the appearance of seizures. In such cases, the use of the medicine is allowed in the following dosage:

• from birth to 3 months, the dosage is 10 mg per kilogram;
• from 3 months to a year, the maximum daily dose is 120 mg;
• from one year to 2 years, the maximum daily dose is 150 mg.

Syrup

This dosage form has a liquid consistency and a pleasant taste, so children swallow it easily. Syrup can be given as early as two months. Sometimes doctors, taking into account the child’s condition at the time of illness, can prescribe syrup in the first weeks of life.

The kit includes a convenient dispenser syringe or measuring spoon, with which the exact amount of suspension is measured. The drug should not be diluted with water; it is better to give the child something to drink after taking it.

The exact dosage is drawn according to the divisions on the syringe:

• from birth to 6 months, the dosage is calculated by the attending physician;
• from 6 months to one year, the maximum dosage is 5 mg, the minimum is 2.5 mg;
• up to 3 years, the dosage is 5 – 7.5 mg;
• from 3 to 6 years – the maximum dosage is 10 mg;
• from 7 to 12 years – about 15 mg.

The medicine begins to act within 30 minutes after administration. At high temperatures, the syrup is given for no more than three days. As a painkiller, the drug can be taken for up to five days.

An analogue of the drug Paracetamol is Panadol. It is approved for children aged 3 months and older. Panadol Baby can be used to relieve fever, inflammation and pain. Can also be used after vaccinations.

Application features

Before giving medicine to a child, you should consult your pediatrician. He will prescribe the correct dosage and tell you about the rules of administration.

• The dosage of the drug depends on the age and weight of the child.
• Paracetamol tablets should be given to relieve fever at intervals of 6 hours. No more than four times a day.
• In children under the age of one year, the temperature should be reduced if it rises above 38 degrees.
• Paracetamol should not be given to infants for more than three days. Their internal organs are not yet fully formed, which creates an extra load on the liver.
• This antipyretic should not be given for prophylaxis.
• For a small child, the tablet must first be dissolved in water.
• You should not use a tablet intended for adults - it is impossible to accurately determine the dosage.
• Nurofen is more irritating to the stomach than Panadol. Therefore, it is better to stop at the last drug.

Tips for taking medications that contain paracetamol

• There are various forms of release of this active ingredient. It can be in candles, syrups or in the form of a suspension. They are best suited for children under one year old.
• To reduce the harmful effects on the liver, the medicine should be given after meals.
• A dosage of 150 mg per kilogram of weight is dangerous for a child’s body.
• An overdose can be recognized by the following symptoms: the skin becomes pale, nausea and vomiting appear. In this case, you need to urgently consult a doctor.

Sometimes, when the temperature is high and falls heavily, children are prescribed two drugs at the same time: Nurofen and Paracetamol. These drugs are given at intervals. Nurofen acts quickly and the effect is longer lasting.

You can combine Nurofen with paracetamol at the same time. In this case, half the dose is taken from each drug.

Contraindications

• Overdose of the drug and frequent use, which negatively affects the functioning of the liver, are not allowed. Nausea and vomiting appear.
• Individual intolerance to the components of the drug. Allergic reactions may occur.
• For children under two years of age, paracetamol should be given with caution - the drug can cause asthma.
• Do not give two paracetamol-based medications at the same time. This will lead to poisoning of the body. Can be given with other antipyretics, for example, Nurofen.
• An overdose can occur if the interval between doses of the medication is not observed. It is better to combine drug treatment with folk remedies.
• The drug is contraindicated for diseases such as anemia, hyperbilirubinemia, and disorders of the kidneys and liver.

If at least one symptom appears, then this medicine should be replaced with another. Nurofen causes allergies less often and causes less harm to internal organs. Just like paracetamol, Nurofen is available in the form of suppositories, tablets and syrup.

There are many medications in pharmacies that contain paracetamol. Panadol is available in tablets, suppositories and syrups. Panadol Baby is specially produced for the little ones

Do not forget that all medications must be kept away from children. It is better to store medications for adults separately from children, so that during the period of illness the child does not mix up medications due to increased anxiety.

Before giving paracetamol to a child, you should consult your doctor. It is he who will tell you which dosage form is best to choose and whether it is worth combining it with other antipyretics. Calculate the exact permitted dosage. Only by following the rules and recommendations can you reduce side effects and overdose.

When a child has a fever, the first medicine that parents use to stabilize the condition is paracetamol, and this is not without reason.

The World Health Organization included this drug in the list of the most effective, safe and cost-effective medicines.

Let's take a closer look at the instructions for using Paracetamol tablets for children (200 and 500 mg): recommended dosages for fever, is it possible to give the medicine to a child at all and how much, what to do if the norm is exceeded?

Description and action

Paracetamol is not a new pharmaceutical. It has been used for treatment since 1893. This is one of the safest non-steroidal anti-inflammatory drugs.

The drug has almost no effect on cyclooxygenase, or COX, produced in peripheral organs and tissues. That's why it has fewer side effects than other NSAIDs.

So, the medicine does not irritate the gastric mucosa, does not lead to disruption of water-mineral metabolism.

At the same time, the drug affects COX, which is produced by the brain, which is responsible for the antipyretic and analgesic properties; the drug has almost no ability to influence inflammatory processes.

Paracetamol is well absorbed from the gastrointestinal tract, therefore, tablet dosage forms along with rectal suppositories are most preferable.

The drug acts quickly, and within 30 minutes after administration its highest concentration is observed inside. The effect lasts up to 4 hours.

The lack of effect when using Paracetamol is a reason to immediately seek medical help.

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Release form and composition

The drug is available in tablets of 0.2 g and 0.5 g(200 and 500 mg). This form is recommended for children over 6 years of age due to possible overdose.

Can be used from 2 years of age, although other forms are preferable at this age.

According to its physical properties, it is a pure white or creamy, pinkish crystalline powder that dissolves in alcohol and is insoluble in water.

Indications

The drug is used if:

• the temperature rises to 38 °C and above (age up to 5 years), to 38.5 °C (age after 5 years) and lasts for at least 4 hours;
• complaints of toothache, headache, muscle pain.

Paracetamol is effective for viral infections (ARVI).

The remedy is also used for chicken pox, measles, flu, rubella, teething, after injuries and burns.

It doesn't help with bacterial infections, complications of ARVI, the effect is short-lived or absent.

Contraindications

The list of contraindications is small in comparison with other drugs. This includes:

• individual intolerance;
• age up to 2 years;
• diseases of the gastrointestinal tract with the formation of ulcers and erosions, gastric bleeding, inflammation, active bleeding;
• progressive pathologies of the kidneys, liver, severe forms of failure of these organs;
• intolerance to acetylsalicylic acid or other NSAIDs;
• hyperkalemia (increased potassium levels in the blood).

How much and how to give

Maximum course of treatment is:

• up to 6 years - 3 days;
• after 6 years - 5 days.

What dose of Paracetamol tablets is needed for children and how to take the medicine correctly?

When prescribing doses, they are guided not by age, but by the weight of the baby. 10–15 mg of active ingredient is prescribed per 1 kg.

Thus, a single dosage of Paracetamol in tablets for children weighing 10 kg is 100–150 mg (0.1–0.15 g), or 1/2–3/4 tablets with a dosage of 200 mg (0.2 g).

Re-appointment should be no earlier than after 4-5 hours. 4–5 doses are allowed per day.

Safe daily dose - up to 60 mg/kg body. This means that a child weighing 10 kg should not be given more than 3 tablets of 200 mg per day.

For teenagers over 12 years of age who weigh more than 40 kg, maximum single dose - 1 g (5 tablets of 0.2 g), daily - 4 g (20 tablets of 0.2 g).

Directions for use, special instructions

The drug is given orally. After eating, 1-2 hours must pass, otherwise absorption will slow down. Drink with plenty of clean water. If the child is small, then the tablet is crushed into powder.

Paracetamol is an emergency medicine that does not cure, but only eliminates the manifestations of the disease. If the cause of the disease is not eliminated, the fever and pain will return.

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Reception features

The question of what dose of paracetamol to give a child in tablets must be decided after consultation with a doctor. When treating, the following features of admission are taken into account:

• if there is liver disease, the dose is reduced;
• when using other drugs simultaneously, you need to make sure that they do not contain paracetamol;
• Do not give your child alcohol-containing medications, as alcohol enhances the absorption of the medication.

Overdose

Taking the drug in a single dose of more than 150 mg/kg of the child’s body weight causes severe, and in some cases fatal, liver damage.

Stages of poisoning:

The development of liver failure is indicated:

• neuropsychiatric disorders (feels sleepy, dizzy, speech impaired, hallucinations);
• pain in the right side under the ribs;
• swelling, abdominal enlargement;
• jaundice;
• bleeding;
• heart rhythm disturbances;
• failure of the function of other organs.

Death from an overdose occurs within 3–5 days.

In case of overdose, wash the stomach, give the patient activated charcoal, call an ambulance. The antidote for paracetamol is acetylcysteine.

In case of liver failure, hospitalization is carried out, treatment is symptomatic. In severe cases, a liver transplant may be required.

Children suffer from poisoning more easily than adults, especially those under 6 years of age., due to the characteristics of metabolism. In mild cases, treatment is carried out at home.

How can an overdose occur?

Drug dosage 0.2 mg is safe. So, for a child weighing 10 kg to become poisoned, he needs to take 1.5 g of the drug per day orally, which is 7.5 tablets.

Exceeding the dose occurs for several reasons:

• parents in a hurry did not pay attention to the content of the active substance;
• other drugs were given at the same time with paracetamol;
• increased the frequency of administration;
• the baby accidentally took the medicine on his own because it was in an accessible place.

Side effects

Although Paracetamol is well tolerated in most cases, it causes side effects:

In recent years scientists started talking about harm and toxicity.

Studies have shown that children who were frequently prescribed paracetamol at the age of 1–3 years develop allergic diseases by the age of 6–7 years -

Eczema, allergies.

Safety is maintained with infrequent use.

There is also evidence that with long-term use of paracetamol, more than 1 tablet per day If the total amount of medication taken is 1000 or more tablets over a lifetime, the risk of developing severe forms of analgesic nephropathy (kidney disease), which leads to end-stage renal failure (complete loss of kidney function), doubles.

Drug interactions

Paracetamol interacts with other drugs, which may affect the safety of therapy.

The following effects may be observed:

• increased harmful effects on the liver, decreased antipyretic effect of paracetamol - in combination with barbiturates of antiepileptic drugs, rifampicin;
• enhancing the effect of coumarin derivatives, salicylic acid, caffeine, codeine;
• an increase in the level of methemoglobin - when used simultaneously with phenobarbital.

Do not combine Paracetamol tablets with other means that contain this active ingredient (Parafex, Paravit, Cold-flu, Coldrex and others).

average price

The average price of Paracetamol 0.2 g, 10 tablets is 6 rubles.

Storage conditions and periods

The expiration date is indicated on the packaging(usually 36 months). Store the drug at a temperature no higher than 25 °C, choosing a place inaccessible to minors.

A prescription is not needed to purchase the medicine.

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Paracetamol for children: instructions for use and reviews

Latin name: Paracetamol children

ATX code: N02BE01

Active substance: Paracetamol

Manufacturer: Rozfarm LLC, Pharmstandard-Leksredstva, Biokhimik, Pharmproekt, Dalkhimfarm, Irbitsky chemical farm plant, Farmapol-Volga, Mega Pharm (Russia), Anqiu Lu An Pharmaceutical Co. (China), LLC Pharmaceutical Company "Zdorovye" (Ukraine)

Updating the description and photo: 19.10.2018

Paracetamol for children is a non-narcotic analgesic.

Release form and composition

Dosage form of release - suspension for oral administration: homogeneous, pink in color, with a characteristic fruity odor (100 and 200 ml in polymer bottles, or bottles made of orange glass, or glass, or polyethylene terephthalate for medicines, sealed with a polymer screw cap with first opening control or “push-turn” system, 1 bottle in a cardboard box without/with a measuring cup or measuring spoon).

Composition of 100 ml suspension:

• active substance: paracetamol – 2.4 g;
• additional components: sodium nipasept (sodium ethyl parahydroxybenzoate, sodium methyl parahydroxybenzoate and sodium propyl parahydroxybenzoate) – 0.15 g, maltitol – 80 g, malic acid – 0.05 g, non-crystallizing sorbitol 70% – 1.33 g, xanthan gum – 0.6 g, anhydrous citric acid – 0.02 g, azorubine dye – 0.001 g, strawberry or orange flavoring – 0.1 g, water – up to 100 ml.

Pharmacological properties

Pharmacodynamics

Paracetamol is a medicinal substance that has antipyretic and analgesic effects. It has virtually no anti-inflammatory properties.

The mechanism of action is due to the ability to block cyclooxygenase in the central nervous system, affecting the centers of thermoregulation and pain.

The drug has virtually no anti-inflammatory properties. It does not affect water-electrolyte metabolism and the condition of the gastrointestinal mucosa (GIT), since it has a very small effect on the synthesis of prostaglandins in peripheral tissues.

Pharmacokinetics

Paracetamol is characterized by high absorption; it is quickly and almost completely absorbed from the gastrointestinal tract. Binds to plasma proteins by 10–25%. The maximum plasma concentration is reached after 30–120 minutes and is 5–20 mcg/ml.

The drug penetrates the blood-brain barrier. Less than 1% of the administered dose passes into mother's breast milk. The distribution of the substance in body fluids is relatively even.

Paracetamol is metabolized primarily in the liver in three main ways, such as oxidation by microsomal liver enzymes, conjugation with sulfates and conjugation with glucuronides. During oxidation, intermediate toxic metabolites are formed, which are subsequently conjugated first with glutathione, then with mercapturic acid and cysteine. For this method of metabolism, the main isoenzymes of the cytochrome P 450 system are CYP2E1 (mainly), CYP1A2 and CYP3A4 (minor role). If there is a deficiency of glutathione in the body, these metabolites can cause damage and necrosis of hepatocytes. Additional metabolic pathways are methoxylation to 3-methoxyparacetamol and hydroxylation to 3-hydroxyparacetamol, which are subsequently conjugated to sulfates or glucuronides.

In children under 10 years of age, the main metabolite of the drug is paracetamol sulfate, in children over 12 years of age - conjugated glucuronide.

Conjugated metabolites of paracetamol (conjugates with glutathione, sulfates, glucuronides) are characterized by low pharmacological activity, including toxic.

When taking a therapeutic dose, the total clearance is 18 l/h, the half-life (T ½) is from 1 to 4 hours. When taking therapeutic doses, 90–100% of the taken dose of paracetamol is excreted in the urine within 24 hours. The main amount of the drug after conjugation is released in the liver in the form of glucuronide (60–80%) and sulfate (20–30%). About 5% of the dose is excreted unchanged.

In elderly patients, paracetamol clearance decreases and T ½ increases.

In patients with severe renal failure (creatinine clearance 10–30 ml/minute), the elimination of paracetamol is slowed down, the rate of elimination of sulfate and glucuronide is lower than in healthy individuals.

Indications for use

Paracetamol suspension for children is prescribed to children aged 3 months to 12 years in the following cases:

• elevated body temperature due to influenza, colds and childhood infectious diseases such as scarlet fever, chicken pox, measles, mumps, etc.;
• toothache, including during teething or extraction, ear pain due to otitis media, headache, sore throat.

Contraindications

• fructose intolerance;
• severe impairment of renal or hepatic function;
• age less than 2 months;
• simultaneous use of other drugs containing paracetamol;
• hypersensitivity to any component of the drug.

Carefully:

• liver dysfunction, including Gilbert's syndrome;
• viral hepatitis;
• genetic absence of the enzyme glucose-6-phosphate dehydrogenase;
• renal dysfunction (creatinine clearance< 30 мл/мин);
• anorexia/bulimia;
• dehydration;
• hypovolemia;
• severe blood diseases (leukopenia, severe anemia, thrombocytopenia);
• diabetes;
• chronic alcoholism.

Instructions for use of Paracetamol for children: method and dosage

Paracetamol suspension for children should be taken orally, preferably 1-2 hours after meals, with plenty of liquid. Immediately before use, the bottle should be shaken well. For correct dosing, a measuring spoon or cup is usually included in the package.

The optimal dose is determined taking into account the age and body weight of the child.

For children over 3 months of age, a single dose of paracetamol is 10–15 mg/kg, dosing frequency is 3-4 times a day. The highest daily dose should not exceed 60 mg/kg.

The drug can be taken in 1 dose at intervals of 4–6 hours, but no more than 4 times during the day.

• 2–3 months (4.5–6 kg): the drug can be used only as prescribed by a doctor*;
• 3–6 months (6–8 kg): 4 ml (96 mg)/16 ml (384 mg);
• 6–12 months (8–10 kg): 5 ml (120 mg)/20 ml (480 mg);
• 1–2 years (10–13 kg): 7 ml (168 mg)/28 ml (672 mg);
• 2–3 years (13–15 kg): 9 ml (216 mg)/36 ml (864 mg);
• 3–6 years (15–21 kg): 10 ml (240 mg)/40 ml (960 mg);
• 6–9 years (21–29 kg): 14 ml (336 mg)/56 ml (1344 mg);
• 9–12 years (29–42 kg): 20 ml (480 mg)/80 ml (1920 mg).

Unless otherwise prescribed by your doctor, you can use the drug for no more than 3 days.

* A single dosage of Paracetamol for children 2-3 months old is 10-15 mg/kg with a dosage frequency of 1-2 times a day. If the temperature does not decrease after taking the second dose, you should consult a doctor. For other indications, the drug can be given to children 2–3 months old only as prescribed by a pediatrician.

Children with impaired renal function need to increase the interval between doses. When creatinine clearance (CC) is 10–50 ml/minute, it should be at least 6 hours;< 10 мл/минуту – 8 часов.

Side effects

Grouping of adverse events by frequency (according to post-registration data): very often - ≥ 1/10, often - from ≥ 1/100 to< 1/10, нечасто – от ≥ 1/1000 до < 1/100, редко – от ≥ 1/10 000 до < 1/1000, очень редко – < 1/10 000, неизвестно – установить частоту на основе имеющихся данных не представляется возможным.

Paracetamol may cause the following side effects:

• from the gastrointestinal tract: rarely - nausea, abdominal pain, diarrhea, vomiting;
• from the blood and lymphatic system: rarely - thrombocytopenia, anemia, leukopenia;
• from the liver and biliary tract: very rarely - impaired liver function; with long-term use in large doses – nephrotoxic and hepatotoxic effects;
• from the immune system: very rarely - angioedema, anaphylaxis;
• from the respiratory system: very rarely with hypersensitivity to acetylsalicylic acid or intolerance to other nonsteroidal anti-inflammatory drugs (NSAIDs) - bronchospasm;
• from the skin and subcutaneous tissues: very rarely - hypersensitivity skin reactions, including skin rash, urticaria, skin itching, Lyell's syndrome (toxic epidermal necrolysis), acute generalized exanthematous pustulosis, Stevens-Johnson syndrome.

Overdose

In case of overdose, there is a risk of developing intoxication, especially in patients receiving concomitant inducers of microsomal liver enzymes, in persons with malnutrition, patients with liver diseases and children. As a result, cholestatic hepatitis, liver failure, cytolytic hepatitis, fulminant hepatitis, sometimes with death, may occur.

Symptoms of acute poisoning: pale skin, stomach pain, nausea, vomiting, anorexia, metabolic acidosis, impaired glucose metabolism (sweating, dizziness, loss of consciousness). After 1-3 days, signs of liver damage appear (pain in the liver area, decreased prothrombin levels, increased bilirubin concentrations and liver enzyme activity), which reach a maximum on days 3-4. In the case of a single dose of paracetamol in a dose of 10,000 mg/kg for an adult, and a dose of 125 mg/kg for children, cytolysis of hepatitis occurs with the development of encephalopathy, metabolic acidosis, complete and irreversible liver necrosis, liver failure - serious complications that can lead to coma and fatal outcome.

In case of severe overdose, progressive encephalopathy, liver failure, coma, and death occur. Acute renal failure with tubular necrosis without severe liver damage may also develop. Its characteristic symptoms are pain in the lumbar region, proteinuria, hematuria, as well as pancreatitis and arrhythmia.

In case of long-term use of the drug in doses exceeding the recommended ones, the development of hepatotoxic and nephrotoxic effects is possible: nonspecific bacteriuria, renal colic, interstitial nephritis and papillary necrosis.

In case of overdose, you should stop taking paracetamol, if possible, do a gastric lavage, take an enterosorbent (activated carbon or polyphepane) and immediately consult a doctor. Treatment is predominantly symptomatic. As soon as possible after an overdose, it is necessary to determine the content of paracetamol in the blood plasma. In case of poisoning, SH-group donors, acetylcysteine ​​and methionine (precursors for glutathione synthesis) must be administered within the first 10 hours. The need for additional therapeutic measures (including further administration of methionine and acetylcysteine) is determined by the doctor depending on the level of paracetamol in the blood and the time that has passed since its administration. Liver tests are performed at the beginning of treatment and every 24 hours thereafter. Liver enzymes return to normal within 1-2 weeks in most cases. Severe overdose may require a liver transplant.

If a child accidentally takes the drug on his own, he should immediately seek medical help, even if he feels well. 24 hours after taking paracetamol, in case of serious liver disorders, treatment is carried out jointly with specialists from a specialized hepatology department or a toxicology center.

special instructions

To avoid overdose during treatment with this drug, you should not take other drugs containing paracetamol at the same time.

Children 2-3 months old can be given the drug only as prescribed by a pediatrician.

If a patient is diagnosed with glutathione deficiency, caution must be exercised as there is an increased risk of overdose. In addition, patients with low glutathione levels, particularly malnourished people with anorexia, patients with a low body mass index and those suffering from chronic alcoholism, are known to develop liver failure. Also in some cases, for example, with sepsis, paracetamol increased the risk of developing metabolic acidosis.

The drug may distort laboratory test results for glucose and uric acid levels in the blood.

If it is necessary to use the drug for more than 5 days, it is recommended to monitor peripheral blood counts and the functional state of the liver.

If there is no effect within 3 days of taking the medicine, you should consult your doctor.

Impact on the ability to drive vehicles and complex mechanisms

Paracetamol has no effect on the speed of reactions and the ability to concentrate.

Use during pregnancy and lactation

There are no negative effects of paracetamol when used during pregnancy and lactation. The drug penetrates the placental barrier and is excreted in breast milk (no more than 0.23% of the dose taken by the mother). Experimental studies have not established any teratogenic, embryotoxic, or mutagenic effects of the substance. However, paracetamol is prescribed to pregnant and breastfeeding women only after assessing the expected benefits and potential risks.

There are no data on the effect on fertility.

Use in childhood

According to the instructions, Paracetamol for children is strictly contraindicated in children under 2 months. At the age of 2 to 3 months, it can be used once to reduce elevated body temperature after vaccination. From the age of 3 months, it is used according to the dosage regimen specified in the instructions.

For impaired renal function

Paracetamol should be used with caution in patients with impaired renal function.

In addition, it is necessary to increase the interval between doses: with CC 10–50 ml/minute - up to 6 hours, with CC< 10 мл/минуту – до 8 часов.

For liver dysfunction

Paracetamol should be used with caution in patients with impaired hepatic function.

Use in old age

In old age, drugs containing paracetamol should be used under close medical supervision.

Drug interactions

Caution should be exercised when concomitant use of drugs that induce microsomal liver enzymes is necessary, such as ethanol, barbiturates, phenylbutazone, anticoagulants, rifampicin, tricyclic antidepressants, zidovudine, isoniazid, anticonvulsants, amoxicillin + clavulanic acid.

Preparations of St. John's wort, butadione and flumecinol increase the production of hydroxylated active metabolites, as a result of which in case of overdose (taking 5000 mg or more), the risk of developing severe liver damage increases.

Paracetamol increases the elimination time of chloramphenicol by 5 times, which increases the likelihood of poisoning. Reduces the effectiveness of uricosuric drugs.

Paracetamol, taken in a daily dose of 4000 mg for 4 or more days, when administered simultaneously, can enhance the effect of indirect anticoagulants, so the International Normalized Ratio should be monitored during and after taking this combination. If paracetamol is taken irregularly, it does not have a significant effect on the effect of anticoagulants.

With long-term simultaneous use of other NSAIDs, the risk of developing renal papillary necrosis, “analgesic” nephropathy and end-stage renal failure increases.

Alcohol consumed during treatment with paracetamol contributes to the development of acute pancreatitis.

Simultaneous long-term use of paracetamol in high doses in combination with salicylates increases the risk of developing bladder or kidney cancer.

Possible drug effects of other drugs on paracetamol:

• probenecid reduces its clearance by almost 2 times due to inhibition of the process of its conjugation with glucuronic acid;
• domperidone and metoclopramide increase the rate of its absorption;
• cholestyramine reduces the rate of its absorption;
• Long-term use of barbiturates reduces its effectiveness;
• diflunisal increases its plasma concentration by 2 times, as a result of which the risk of developing hepatotoxicity increases;
• phenytoin reduces its effect and increases the risk of hepatotoxicity;
• myelotoxic drugs enhance the manifestations of its hematotoxicity.

Inhibitors of microsomal oxidation (including cimetidine), when used simultaneously, reduce the risk of hepatotoxicity.

Analogues

Analogues of Paracetamol for children are: Paracetamol (suspension), Calpol, Daleron, Children's Panadol.

Terms and conditions of storage

Shelf life – 3 years.

Storage conditions: protected from light, out of reach of children, temperature up to 25 °C.