home Folk remedies What does Norfloxacin help with? Why is Norfloxacin prescribed for urinary tract diseases? Norfloxacin health instructions for use

What does Norfloxacin help with? Why is Norfloxacin prescribed for urinary tract diseases? Norfloxacin health instructions for use

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

The drug Norfloxacin

Norfloxacin– a broad-spectrum antibacterial drug from the group of fluoroquinolones, a uroantiseptic. It has a bactericidal effect, destabilizing the DNA chain in the bacterial cell. Used as antibiotic.

20-40% of the drug is well absorbed from the gastrointestinal tract, while food slows down the absorption process. An hour after taking the tablet, the therapeutic concentration of the drug in the blood is achieved. Metabolized slightly in the liver, excreted in bile and urine. The drug lasts for about 12 hours.

Norfloxacin is highly soluble in fats, so it easily penetrates into organs and tissues: kidneys, uterus, ovaries, seminiferous tubules, abdominal organs, bile, breast milk.

Release forms

Norfloxacin is available in tablets and drops for use in the eyes and ears.

1 tablet of the drug contains 400 mg of the active substance (norfloxacin), lactose, corn starch, magnesium stearate, talc and other excipients. Tablets are packaged in 10 or 20 pieces in polymer jars or 10 pieces in blisters. One cardboard package contains 1 or 2 blisters (10 or 20 tablets).
Drops are produced in 5 ml bottles. The bottle has a dropper cap, which is convenient for use. 1 ml of drops contains 3 mg of active substance and excipients.

Instructions for use of Norfloxacin

Indications for use

Norfloxacin is prescribed to treat infections caused by microbes that are sensitive to it. Most sensitive to the drug:

Insensitive to Norfloxacin: ureaplasma, treponema pallidum, nocardia, anaerobic bacteria (peptococci, peptostreptococci, clostridia, etc.).

Indications for oral use:

Cystitis, pyelonephritis, prostatitis, urethritis and other acute and chronic infections of the urinary system.
Salmonellosis, shigellosis, traveler's diarrhea.
Prevention of relapse of genitourinary tract diseases.
Prevention of sepsis in patients with granulocytopenia.

Norfloxacin is also prescribed for the prevention of infections during instrumental diagnostic procedures and surgical interventions in urological practice.

The drug is used locally:
1. In ophthalmology for treatment:

blepharoconjunctivitis;
acute inflammation of the meibomian glands;
corneal ulcers;
infections after removing a foreign body from the conjunctiva or cornea;
chemical burns.

2. In otolaryngology for treatment:

external otitis;
acute and chronic otitis media.

And also for the prevention of infectious complications during operations on the organs of hearing and vision.

Contraindications

Norfloxacin is contraindicated:

In end-stage renal failure.
In case of hypersensitivity to Norfloxacin and drugs from its group.
With a lack of glucose-6-phosphate dehydrogenase in the body.
During pregnancy and lactation.
Children under 15 years of age.

Side effects

Side effects of the drug occur in approximately 3% of cases of its use. The digestive tract, central nervous system, and skin most often react.

From the digestive system may cause nausea, bitterness in the mouth, loss of appetite, abdominal cramps or pain, diarrhea, pseudomembranous colitis, dysbacteriosis. Sometimes liver function indicators (liver transaminases) transiently increase in the blood.

From the side of the central nervous system Side effects of Norfloxacin include headache, dizziness, drowsiness or insomnia, and occasionally convulsions, hallucinations and disorientation. Elderly patients taking Norfloxacin may complain of tinnitus, irritation, fatigue, depression, unreasonable fear or anxiety.

Skin manifestations can be in the form of rash, itching, urticaria, edema, increased photosensitivity, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis.

From other systems and organs The following reactions may occur:

Urinary system: impaired urination, bleeding from the urethra, excessive urination, glomerulonephritis, crystalluria, the appearance of protein in the urine, increased concentrations of creatinine and urea in the blood plasma.
The cardiovascular system: arrhythmias, tachycardia, arterial hypotension, vasculitis.
Musculoskeletal system: inflammation and ruptures of tendons, joint pain.

Manifestations of allergies are possible in the form of angioedema, anaphylaxis, and respiratory failure. A blood test reveals an increase in the number of eosinophils, a decrease in hematocrit and the number of leukocytes, agranulocytosis, and hemolytic anemia.

Treatment with Norfloxacin

How to use Norfloxacin?
Before prescribing the drug, it is advisable to determine whether the flora that caused the disease is sensitive to it.

The tablet is swallowed whole with a small amount of water, two hours before meals, antacids, medications containing iron, zinc, magnesium, calcium.

The drug is used with caution in patients with impaired liver and kidney function, in patients with epilepsy, cerebral atherosclerosis. The drug is immediately discontinued if pain in the tendons, allergic reactions, or signs of bronchospasm occur. In this case, you must immediately consult a doctor.

When treating with Norfloxacin, in order to avoid the formation of stones in the kidneys and bladder, it is necessary to consume large amounts of fluid.

Drops must be warmed to body temperature before instillation into the eyes and ears.

Before instilling the medicinal solution into the ear, the external auditory canal is cleared of pus. When installing drops, the patient should tilt his head or lie on his side. After instillation, the head should be kept in this position for about two minutes. Then close the ear canal with a cotton wool turunda.

After instilling drops into your eyes, you should refrain from driving and other activities that require concentration for 30 minutes. Due to the possibility of photophobia, it is necessary to wear sunglasses and avoid bright light during treatment with Norfloxacin.

Dosage
A single dose of the drug when taken orally is usually 1-2 tablets (400-800 mg) with a dosage frequency of 1-2 times a day. The maximum daily dose is 1.5 g.

For uncomplicated infections of the urinary system, the course of administration is about 3 days, for complicated ones - about 7-10 days. For chronic processes, the course can be increased to 3 months.

The exact dose and duration of the course are prescribed by the doctor individually for each patient.

In case of overdose, it is necessary to urgently rinse the stomach with a tube or by inducing vomiting, then symptomatic treatment should be prescribed.

In the form of drops, Norfloxacin is most often prescribed in combination with systemic antimicrobial therapy.

1-2 drops of the drug are instilled into the eyes in accordance with the doctor’s prescription:

for severe acute infections - every 15-30 minutes during the day;
for moderate symptoms – up to six times a day;
for trachoma - 2 drops 2-4 times a day for 1-2 months.

2-5 drops of the drug are instilled into the ear up to 3 times a day.

After the symptoms of the disease disappear, treatment is continued for two days.

Norfloxacin for children

Norfloxacin is contraindicated in children and adolescents under 15 years of age. For adolescents over 15 years of age, the drug is prescribed in the same way as for adults.

Use during pregnancy and lactation

The effect of Norfloxacin on the fetus has not been studied enough. Experimental studies have revealed that the drug causes disruption of joint development. Therefore, prescribing the drug during pregnancy is possible only for health reasons.

It is not recommended to take the medicine during lactation. If the drug is prescribed, breastfeeding of the child should be stopped.

Norfloxacin for cystitis

In the treatment of cystitis, Norfloxacin is very effective: it quickly and effectively affects the microflora characteristic of most urinary tract infections, suppressing its growth. It also acts bactericidal against one of the most antibiotic-resistant bacteria - Pseudomonas aeruginosa, which can also be the causative agent of cystitis.

The dose of Norfloxacin and the duration of the course for the treatment of cystitis are determined by the doctor.

Drug interactions

Norfloxacin:

Increases the concentration of Theophylline in the blood.
When administered simultaneously with cyclosporines, it increases the concentration of creatinine in the blood serum.
Strengthens the anticoagulant (anti-clotting) effect of Warfarin.
May cause severe hypotension when administered concomitantly with antihypertensive drugs.

Norfloxacin– a broad-spectrum antibacterial drug from the group of fluoroquinolones, a uroantiseptic. It has a bactericidal effect, destabilizing the DNA chain in the bacterial cell. Used as

antibiotic .

Norfloxacin is highly soluble in fats, so it easily penetrates into organs and tissues: kidneys, uterus, ovaries, seminiferous tubules, abdominal organs, bile, breast milk.

Release forms

Norfloxacin is available in tablets and as

eye drops

1 tablet of the drug contains 400 mg of the active substance (norfloxacin), lactose, corn starch, magnesium stearate, talc and other excipients. Tablets are packaged in 10 or 20 pieces in polymer jars or 10 pieces in blisters. One cardboard package contains 1 or 2 blisters (10 or 20 tablets).
Drops are produced in 5 ml bottles. The bottle has a dropper cap, which is convenient for use. 1 ml of drops contains 3 mg of active substance and excipients.

Instructions for use of NorfloxacinIndications for use

Norfloxacin is prescribed for the treatment

infections

Caused by microbes sensitive to it. Most sensitive to the drug:

Insensitive to Norfloxacin: ureaplasma, treponema pallidum, nocardia, anaerobic bacteria (peptococci, peptostreptococci, clostridia, etc.).

Indications for oral use:

Cystitis, pyelonephritis, prostatitis, urethritis and other acute and chronic infections of the urinary system.
Gonorrhea.
Cervicitis, endometritis.
Salmonellosis, shigellosis, traveler's diarrhea.
Prevention of relapse of genitourinary tract diseases.
Prevention of sepsis in patients with granulocytopenia.

Norfloxacin is also prescribed for the prevention of infections during instrumental diagnostic procedures and surgical interventions in urological practice.

The drug is used locally:1. In ophthalmology for treatment:

conjunctivitis;
keratitis;
blepharitis;
blepharoconjunctivitis;
dacryocystitis;
acute inflammation of the meibomian glands;
corneal ulcers;
infections after removing a foreign body from the conjunctiva or cornea;
chemical burns.

2. In otolaryngology for treatment:

external otitis;
acute and chronic otitis media.

And also for the prevention of infectious complications during operations on the organs of hearing and vision.
Contraindications

Norfloxacin is contraindicated:

For liver failure.
In terminal stages of renal failure.
In case of hypersensitivity to Norfloxacin and drugs from its group.
With a lack of glucose-6-phosphate dehydrogenase in the body.
During pregnancy and lactation.
Children under 15 years of age.

Side effects

Side effects of the drug occur in approximately 3% of cases of its use. The digestive tract, central nervous system, and skin most often react.

From the digestive system Nausea, bitterness in the mouth, loss of appetite, cramps or abdominal pain, diarrhea, pseudomembranous colitis, dysbacteriosis may be bothersome. Sometimes liver function indicators (liver transaminases) transiently increase in the blood.

From the side of the central nervous system Side effects of Norfloxacin include headache, dizziness, drowsiness or insomnia, and occasionally convulsions, hallucinations and disorientation. Elderly patients while taking Norfloxacin may complain of tinnitus, irritation, fatigue, depression, unreasonable fear or anxiety.

Skin manifestations may be in the form of rash, itching, urticaria, swelling, increased photosensitivity, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis.

From other systems and organs The following reactions may occur:

Urinary system: impaired urination, bleeding from the urethra, excessive urination, glomerulonephritis, crystalluria, the appearance of protein in the urine, increased concentrations of creatinine and urea in the blood plasma.
The cardiovascular system: arrhythmias, tachycardia, arterial hypotension, vasculitis.
Musculoskeletal system: inflammation and ruptures of tendons, joint pain.

How to use Norfloxacin? Before prescribing the drug, it is advisable to determine whether the flora that caused the disease is sensitive to it.

The tablet is swallowed whole with a small amount of water, two hours before meals, antacids, drugs containing iron, zinc, magnesium, calcium.

The drug is used with caution in patients with impaired liver and kidney function, in patients with epilepsy, and cerebral atherosclerosis. The drug is immediately discontinued if pain in the tendons, allergic reactions, or signs of bronchospasm occur. In this case, you must immediately consult a doctor.

When treating with Norfloxacin, in order to avoid the formation of stones in the kidneys and bladder, it is necessary to consume large amounts of fluid.

Drops must be warmed to body temperature before instillation into the eyes and ears.

Dosage A single dose of the drug when taken orally is usually 1-2 tablets (400-800 mg) with a dosage frequency of 1-2 times a day. The maximum daily dose is 1.5 g.

The exact dose and duration of the course are prescribed by the doctor individually for each patient.

In case of overdose, it is necessary to urgently rinse the stomach with a tube or by inducing vomiting, then symptomatic treatment should be prescribed.

In the form of drops, Norfloxacin is most often prescribed in combination with systemic antimicrobial therapy.

1-2 drops of the drug are instilled into the eyes in accordance with the doctor’s prescription:

for severe acute infections - every 15-30 minutes during the day;
for moderate symptoms – up to six times a day;
for trachoma - 2 drops 2-4 times a day for 1-2 months.

2-5 drops of the drug are instilled into the ear up to 3 times a day.

After the symptoms of the disease disappear, treatment is continued for two days.

Norfloxacin for children

Norfloxacin is contraindicated in children and adolescents under 15 years of age. For adolescents over 15 years of age, the drug is prescribed in the same way as for adults.

The effect of Norfloxacin on the fetus has not been studied enough. Experimental studies have revealed that the drug causes disruption of joint development. Therefore, prescribing the drug for

pregnancy

possible only for health reasons.

Norfloxacin for cystitis

In the treatment of cystitis, Norfloxacin is very effective: it quickly and effectively affects

microflora

Characteristic of most urinary tract infections, suppressing its growth. It acts bactericidal and against one of the most antibiotic-resistant bacteria -

Pseudomonas aeruginosa

Which can also be the causative agent of cystitis.

The dose of Norfloxacin and the duration of the course for the treatment of cystitis are determined by the doctor.

More about cystitis

Drug interactions Norfloxacin:

Increases the concentration of Theophylline in the blood.
When administered simultaneously with cyclosporines, it increases the concentration of creatinine in the blood serum.
Strengthens the anticoagulant (anti-clotting) effect of Warfarin.
May cause severe hypotension when administered concomitantly with antihypertensive drugs.
Reduces the effect of drugs from the nitrofuran group.
Slows down the period of caffeine removal from the body.

Antacids (Almagel, Gastal), as well as drugs that contain calcium, zinc, and iron salts, reduce the absorption of Norfloxacin. Therefore, the interval between taking Norfloxacin and antacids should be at least 2 hours.

When prescribing Norfloxacin simultaneously with hypnotics of the barbiturate group, as well as with anesthetics, it is necessary to monitor blood pressure, pulse rate, and electrocardiogram parameters.

When using the drug together with Theophylline and non-steroidal anti-inflammatory drugs, the risk of convulsions and epileptiform seizures increases.

Norfloxacin analogs

Trade names of Norfloxacin:

Reviews about the drug

According to reviews from patients who took Norfloxacin, the drug is in most cases effective against diseases of the genitourinary system and digestive tract.

A number of patients describe in their reviews the side effects that have developed: depression, irritability; Some people developed swelling of the face and itchy skin.

Price of the drug in Russia and Ukraine Cost of Norfloxacin in Russia:

62-75 rub. for 10 tablets;
116-136 rub. for 20 tablets;
115-130 rub. for 1 bottle of drops.

The price of generics varies:

From 113 to 144 rubles. for 10 tablets of Nolicin;
from 100 to 127 rub. for 10 tablets of Norbactin;
from 114 to 125 rub. for 10 Normax tablets;
from 102 to 142 rub. for 1 bottle of Normax in the form of drops.

The cheapest generic is Loxone (52 rubles for 10 tablets), the most expensive is Nolitsin (144 rubles for 10 tablets).

Cost of Norfloxacin in Ukraine In Ukraine, the price of 10 tablets of Norfloxacin ranges from 19 to 27 hryvnia, the price of 1 bottle of drops is about 9 hryvnia.

Generic price: 25 hryvnia for 10 tablets of Norbactin, 35-40 hryvnia for 10 tablets of Normax. The maximum price is 115 hryvnia for 10 tablets of Nolicin.

The cost of generic drops is about 35-40 hryvnia for 1 bottle.

The drug is available with a doctor's prescription.

ATTENTION! The information posted on our website is for reference or popular information and is provided to a wide range of readers for discussion. Prescription of medications should be carried out only by a qualified specialist, based on the medical history and diagnostic results.

Norfloxacin tablets: instructions for use. Norfloxacin is a drug with an antibacterial effect. The drug Norfloxacin belongs to drugs with pronounced antimicrobial activity and uroseptics. It has antibacterial properties. Weakens the microbial DNA chain.

This drug is almost completely absorbed from the digestive organs. If the medicine is taken on a full stomach, this process slows down.

Within an hour after its use, the required concentration of the active substance in the blood is ensured. Metabolized to a small extent in the liver. It leaves the body with bile and urine.

Norfloxacin is effective for 12 hours. It dissolves freely in fats, making it easily delivered to organs and tissues.

Norfloxacin drugs have different release forms. Presented in tablet form, eye and ear drops.

1 tablet contains 400 mg of the main substance. In addition, it contains lactose, corn starch, magnesium stearate, talc and other additional components.

The medicine in tablet form is packaged in plastic jars of 10-20 pieces and blisters of 10 pieces. One package includes 1-2 tablets.

The solution is placed in 5 ml bottles. The container is equipped with a dropper cap, making the drug convenient to use for installations. 1 ml of the product contains 3 mg of norfloxacin and additional components.

Norfloxacin is an antibiotic that is prescribed to fight infections caused by microorganisms that are sensitive to it. Its description is confirmed by the fact that it has a strong effect on staphylococci, Escherechia, salmonella, Neisseria, Proteus, hafnia, chlamydia and other pathogens.

Norfloxacin tablets are not suitable for combating ureoplasma, nocardia, and anaerobic bacteria.

The drug is also prescribed to prevent relapses of pathologies of the genitourinary organs.

Norfloxicin is used as a preventive measure against sepsis in patients with granulocytopenia.

The medicine is effective as a prophylaxis against infections during diagnostic examinations, which involve the use of instruments and during urological operations.

Local therapy

The drug is also used in ophthalmology

The drug in drops is used for local therapy.

In ophthalmology:

for conjunctivitis;
blepharitis;
dacryocystitis;
acute inflammation of the upper eyelid;
infections after foreign objects are removed from the conjunctiva or cornea.

Norfloxacin is also used in otolaryngology. Norfloxacin, the indications for which are otitis media of varying degrees, is also prescribed for infectious complications after surgical interventions on the eyes and ears.

Contraindications

The drug has a number of specific contraindications. These include:

renal dysfunction;
late stages of renal failure.

If there is an individual intolerance to the active substance of the drug, it is prohibited to use it.

The use of Norfloxacin should be discontinued during pregnancy and breastfeeding.

The drug should not be taken by patients under 15 years of age.

Side effects

Adverse drug reactions are extremely rare

Adverse reactions from the drug are extremely rare, occurring in about 3% of cases of its use. Most often, side effects occur on the gastrointestinal tract, central nervous system and skin. The negative effect of the drug manifests itself in the form of nausea, lack of appetite, diarrhea, dysbacteriosis, and abdominal pain. In some cases, indicators may be detected in the blood that indicate increased liver function.

As for the central nervous system, here the adverse reaction makes itself felt by headache, weakness, insomnia, convulsions, and hallucinations.

Elderly patients may experience tinnitus, general deterioration in health, anxiety, and irritability after consuming Norfloxacin.

Skin manifestations include rash, itching, swelling, and increased photosensitivity.

In some cases, other organs also react negatively to taking this drug. From the urinary system, problems with urination may appear. Sometimes there is bleeding along with the urine and an increase in protein in the urine.

The musculoskeletal system is characterized by inflammatory processes in the tendons, their ruptures, and pain in the joints.

Quincke's edema and breathing problems are also possible. A blood test in this case indicates an increase in the level of eosinophils and leukocytes.

Therapy

Before prescribing a medicine to a patient, the doctor must conduct certain studies and find out whether the flora that caused the disease is sensitive to this drug.

There is no need to crush the tablet for administration. It must be swallowed in its original form with water. You need to take the medicine two hours before meals.

It is not recommended to use Norfloxacin and drugs containing iron, zinc, magnesium and calcium at the same time. It is important that there is a break of several hours between taking these medications.

If patients have problems with the kidneys and liver, the product should be used with caution, as prescribed by a doctor. The same applies to patients suffering from epilepsy and cerebral atherosclerosis.

As soon as pain in the tendons and allergies appear, you should immediately stop taking the medicine. If you have bronchospasms, drinking it is also prohibited. If such phenomena make themselves felt, you should immediately notify your doctor.

Treatment with Norfloxacin has its own characteristics. When using this drug to treat a particular pathology, you need to drink enough fluid to prevent the formation of kidney stones.

If the drug is used in the form of drops, then before dripping it into the ear or eyes, they should be warmed to body temperature. The external auditory canal must be prepared for the procedure. Only after it has been cleared of purulent formations can you drip the medicine into the ear. At the time of the procedure, the patient needs to tilt his head or lie on his side.

After installation, you must remain in this position for several minutes. The ear canal is plugged with a cotton ball.

When using eye drops, you need to remember that they impair concentration and visibility for half an hour. That is why you should not drive during this period.

Therapy with Norfloxacin is often accompanied by the appearance of photophobia. In this case, you need to wear sunglasses and try not to expose your eyes to bright light.

Dosage

Norfloxacin instructions for use, which involves taking 1-2 tablets of the medicine at a time, can be taken 1-2 times a day.

If the urinary system caused by infection is being treated, the drug can be taken for 3 days. For complex diseases of these organs, therapy can last more than a week.

For chronic disease, the course often lasts several months.

The exact dosage and duration of therapy should be determined by the doctor, focusing on the specifics of the disease and the general health of the patient.

If the maximum dose of the drug has been exceeded, you must immediately rinse the stomach using a tube. You can also direct actions to induce vomiting. After this, symptomatic treatment should be prescribed.

Norfloxacin drops are usually combined with systemic antimicrobial treatment. You can drop 1-2 drops of medicine into one eye. The doctor should tell you how often to do this.

If the infection is pronounced, the procedure should be performed every 15-30 minutes. For mild cases – up to 6 times a day.

To treat trachoma, the medicine is instilled 2-4 times a day for 30-60 days.

2-5 drops of Norfloxacin are dripped into the ear no more than 3 times a day.

When the symptoms stop bothering you, therapy should not be stopped. It is necessary to instill the drug for another two days.

Norfloxacin for children

The drug is strictly contraindicated in patients under 15 years of age. Persons over 15 can use the medicine in the same way as adults.

Use during pregnancy and lactation

The effect of the active component of the drug on the fetus has not been fully studied. Studies have shown that this medicine can negatively affect the development of joints, so whether it can be given to a patient during pregnancy must be decided by the doctor.

Therapy with this drug while breastfeeding is prohibited. If its use is unavoidable, lactation should be interrupted.

Treatment of cystitis with Norfloxacin

The dose of the drug and duration of therapy for cystitis is prescribed by the doctor.

Norfloxacin for cystitis is prescribed quite often due to its effectiveness. The medicine has a detrimental effect on the microflora, which is characteristic of many urinary tract infections.

The drug has a bactericidal effect on bacteria that are resistant to antimicrobial drugs. Namely, Pseudomonas aeruginosa, which often provokes inflammation of the bladder.

The dose of the drug and duration of therapy for cystitis are prescribed by a urologist or gynecologist.

Interaction with other drugs

Norfloxacin:

Increases the concentration of Theophylline in the blood.
If taken along with cyclosporines, it increases the concentration of creatinine in the blood serum.
Activates the anticoagulant effect of Warfarin.
May result in severe hypotension when using antihypertensive drugs.
Slows down the effect of nitrofuran drugs.
Prevents the accelerated elimination of caffeine from the body.

Preparations in the form of Almagel and Gastal and those that include calcium salts, zinc, and iron reduce the absorption of Norfloxacin. It is for this reason that it is important that there is a 2-hour gap between the use of this drug and antacids.

If the medicine is prescribed in combination with sleeping pills from a number of barbiturates and anesthetics, you need to monitor your blood pressure and pulse rate. It is also necessary to take into account electrocardiogram data.

Taking Norfloxacin together with Theophylline and non-steroidal drugs with anti-inflammatory effects can lead to convulsions and epileptic seizures.

Norfloxacin is an antimicrobial drug from the fluoroquinolone group.

Release form and composition

Norfloxacin is produced in the form of film-coated tablets: yellow, biconvex, oblong with rounded ends, with a score line on one side; on the cross section - two layers, the inner layer is pale yellow or white (10 pieces each in blister packs made of polyvinyl chloride film and varnished printed aluminum foil, 1 or 2 packs in a cardboard box).

1 tablet contains:

Active substance: norfloxacin – 200 or 400 mg;
Auxiliary components (200/400 mg of active substance, respectively): aerosil (colloidal silicon dioxide) – 3.6/7.2 mg, magnesium stearate – 3.6/7.2 mg, microcrystalline cellulose – 120.4/240.8 mg, croscarmellose sodium – 10.8/21.6 mg, crospovidone – 21.6/43.2 mg;
Shell (200/400 mg of active substance, respectively): hydroxypropyl methylcellulose (hypromellose) – 6.57/13.14 mg, polyethylene glycol 6000 (macrogol 6000) – 2.2/4.4 mg, titanium dioxide – 2.2/4, 4 mg, yellow quinoline dye - 0.03/0.06 mg.

Pharmacological properties

Pharmacodynamics

Norfloxacin is an antimicrobial drug belonging to the fluoroquinolone group. It has a bactericidal effect, realized by inhibiting DNA gyrase, which ensures the stability and supercoiling of bacterial DNA. This causes destabilization of the DNA chain and the death of bacteria.

Gram-negative aerobic microorganisms (Serratia marcescens, Citrobacter freundii, Pseudomonas aeruginosa, Enterobacter cloacae, Enterobacter aerogenes, Proteus vulgaris, Proteus mirabilis, Escherichia coli, Neisseria gonorrhoeae, Klebsiella pneumonia) and Gram-positive aerobic microorganisms ( Streptococcus agalactiae, Enterococcus faecalis, Staphylococcus saprophyticus, Staphylococcus epidermidis, Staphylococcus aureus).

In vitro, norfloxacin acts on such gram-negative aerobes as Pseudomonas stutzeri, Pseudomonas fluorescens, Citrobacter diversus, Providencia stuartii, Providencia rettgeri, Providencia alcalifaciens, Edwardsiella tarda, Morganella morganii, Enterobacter agglomerans, Klebsiella oxytoca, Haemophilus ducreyi, as well as plasma urealyticum.

Norfloxacin does not show activity against obligate anaerobes.

Pharmacokinetics

When taken orally, absorption of norfloxacin occurs rapidly, and the extent of absorption is 30–40%. Taking with food reduces absorption. The maximum content of norfloxacin in blood plasma when taking 800, 400 and 200 mg is 2.4, 1.5 and 0.8 mcg/ml, respectively. The maximum concentration in blood plasma is recorded after 1 hour. The half-life averages 3-4 hours. The equilibrium concentration of norfloxacin in blood plasma is achieved within 2 days.

In elderly patients, the rate of elimination is slower (due to age-related decline in renal function). Therefore, after oral administration of 400 mg of norfloxacin, the area under the concentration-time pharmacokinetic curve is 6.97–12.63 mg/h/ml, and the maximum concentration varies from 1.25 to 2.79 μg/ml (in young patients these the indicators are 6.4 mg/h/ml and 1.5 μg/ml, respectively). The half-life in this category of patients is 4 hours.

Norfloxacin is bound to plasma proteins by 10–15%.

In chronic renal failure (creatinine clearance less than 30 ml/min/1.73 m2), the half-life increases to 6.5 hours.

Norfloxacin is involved in metabolic processes in the liver. Renal clearance is 275 ml/min. The substance is excreted through the kidneys within 24 hours: unchanged – 26–32%, in the form of a metabolite with weak pharmacological activity – 5–8%. Subsequently, less than 1% of the dose taken is excreted in the urine. About 30% of norfloxacin is excreted through the intestines. In elderly patients, approximately 22% of the dose taken is excreted by the kidneys (renal clearance is 154 ml/min).

2-3 hours after oral administration of 400 mg of Norfloxacin, its concentration in the urine exceeds 200 mcg/ml, and for 12 hours it is maintained at a level of 30 mcg/ml or higher. At pH 7.5, the solubility of the substance decreases.

Indications for use

Norfloxacin is prescribed for the treatment of infections caused by microorganisms sensitive to the action of the active substance, including prostatitis, uncomplicated gonorrhea, urinary tract infections (with the exception of chronic complicated and acute pyelonephritis).

Contraindications

Absolute:

Glucose-6-phosphate dehydrogenase deficiency;
Tendon rupture and tendinitis associated with fluoroquinolones (including historical data);
Children under 18 years of age;
Pregnancy and lactation period;
Hypersensitivity to the components of the drug.

Relative (Norfloxacin is prescribed with caution in the presence of the following diseases/conditions):

Epilepsy;
Liver/renal failure;
Convulsive syndrome;
Myasthenia gravis.

Instructions for use of Norfloxacin: method and dosage

Norfloxacin is taken orally.

The dosage regimen is determined by the indications.

Urinary tract infections: 2 times a day, 400 mg, average course duration - 7-10 days, uncomplicated cystitis - 3-7 days, chronic recurrent urinary tract infections - up to 3 months;
Acute bacterial gastroenteritis: 2 times a day, 400 mg, average course duration – 5 days;
Acute gonococcal urethritis, pharyngitis, proctitis, cervicitis: 800 mg once;
Typhoid fever: 3 times a day, 400 mg, average course duration - 2 weeks.

Prevention:

Sepsis: 2 times a day 400 mg;
Bacterial gastroenteritis: 400 mg per day;
Travelers' diarrhea: 400 mg per day (the drug should be started 1 day before departure, therapy is continued throughout the entire travel period, but not longer than 3 weeks);
Recurrent urinary tract infections: 200 mg per day.

The use of reduced daily doses (1/2 therapeutic dose 2 times a day or a full single dose 1 time a day) is required for patients with creatinine clearance below 20 ml per minute (or serum creatinine concentration greater than 5 mg/100 ml), as well as those on hemodialysis patients.

Side effects

Cardiovascular system: palpitations, myocardial infarction;
Central nervous system: sleep disturbance, headache, dizziness, tingling in the fingers, anxiety, drowsiness, insomnia, depression;
Urinary system: renal colic;
Digestive system: diarrhea, nausea, itching of the anus, anorexia, abdominal pain, heartburn, pain in the rectum or anus, dyspepsia, constipation, loose stools, flatulence, vomiting, dry oral mucosa, ulceration of the oral mucosa, bitter taste in mouth;
Hematopoietic system: eosinophilia, leukopenia, thrombocytopenia, neutropenia;
Skeletal-motor system: bursitis, swelling of the feet and hands;
Sense organs: blurred visual perception;
Skin: itching, erythema, rash, urticaria;
Laboratory indicators: decrease in hemoglobin and hematocrit, increased activity of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, proteinuria, hypercreatininemia, increased urea concentration in the blood, glycosuria;
Others: allergic reactions, chills, hyperhidrosis, edema, asthenia, fever, back and chest pain, dysmenorrhea.

As a result of post-marketing studies, the following violations were recorded:

Central nervous system: peripheral neuropathy, convulsions, tremor, myoclonus, Guillain-Barré syndrome, ataxia, hypoesthesia, paresthesia, mental disorders (including confusion);
Cardiovascular system: prolongation of the QT interval, ventricular arrhythmia (including tachycardia of the “pirouette” type);
Skeletal-motor system: exacerbation of myasthenia gravis, tendon rupture, tendinitis, increased activity of creatine phosphokinase;
Urinary system: renal failure, interstitial nephritis;
Digestive system: hepatitis, stomatitis, pseudomembranous colitis, cholestatic jaundice, pancreatitis, liver failure (including fatal);
Hematopoietic system: hemolytic anemia, agranulocytosis;
Sense organs: diplopia, tinnitus, hearing loss, dysgeusia;
Skin: toxic epidermal necrolysis, Stevens-Johnson syndrome, exfoliative dermatitis, erythema multiforme, photosensitivity;
Allergic reactions: angioedema, anaphylactoid reactions, shortness of breath, vasculitis, arthralgia, arthritis, myalgia;
Others: hypoglycemia, prolongation of prothrombin time, albuminuria, candiduria, cylindruria, crystalluria, dysphagia, hyperglycemia, hyperkalemia, hypercholesterolemia, postural hypotension, hypertriglyceridemia, hematuria, liver necrosis, nystagmus, vaginal candidiasis.

Overdose

Symptoms of an overdose of Norfloxacin are drowsiness, puffy face, “cold” sweat, nausea, vomiting. At the same time, the main hemodynamic parameters practically do not change.

A specific antidote is unknown. As treatment, gastric lavage and adequate hydration therapy, accompanied by forced diuresis, are recommended. The patient must be examined and left under observation in the hospital for several days.

special instructions

During therapy, patients should receive an adequate amount of fluid under diuresis control.

During the use of Norfloxacin, the prothrombin index may increase (surgical interventions must be carried out under the control of the state of the blood coagulation system).

Taking the drug increases the likelihood of developing tendinitis and tendon rupture. Risk factors include: chronic renal failure, kidney, lung or heart transplantation, age over 60 years, combination therapy with glucocorticosteroids, increased physical activity, history of tendon damage (including rheumatoid arthritis). These disorders may develop several months after completion of the course. When the first signs of tendonitis or tendon rupture appear, you must stop taking Norfloxacin and consult a specialist.

During therapy, exposure to direct sunlight should be avoided.

Norfloxacin may lower the seizure threshold and lead to seizures. Also, fluoroquinolones can stimulate the central nervous system, causing hallucinations, anxiety, tremors, toxic psychoses, confusion, and contribute to increased intracranial pressure.

Norfloxacin may lead to the development of pseudomembranous colitis caused by Clostridium difficile. In these cases, the drug should be discontinued and appropriate therapy should be prescribed (metronidazole or vancomycin orally).

Norfloxacin is not prescribed for the treatment of syphilis (the drug is not effective).

Norfloxacin can cause peripheral neuropathy (in the form of paresthesia, hypoesthesia, dysesthesia, muscle weakness). To avoid the development of irreversible changes, when the first signs of the disease appear (tingling, pain, weakness or numbness in the limbs, disturbance of other types of sensitivity), therapy should be discontinued.

When driving vehicles and performing potentially dangerous work that requires rapid psychomotor reactions and increased concentration, caution must be exercised (especially when used simultaneously with ethanol).

Use during pregnancy and lactation

According to the instructions, Norfloxacin is contraindicated during pregnancy and breastfeeding, since clinical studies have proven an increased risk of developing arthropathy.

Drug interactions

When Norfloxacin is used together with certain drugs, the following effects may occur:

Theophylline: decrease in its clearance (reduction of its dose is required);
Nitrofurans: decrease in their effectiveness;
Indirect anticoagulants, cyclosporine: increase in their concentration in blood serum;
Drugs that lower the seizure threshold (including non-steroidal anti-inflammatory drugs): development of seizures;
Antacids containing aluminum or magnesium hydroxide, as well as drugs containing sucralfate, Zn2+, Fe: decreased absorption of norfloxacin (the interval between their use should be at least 4 hours);
CYP1A2 isoenzymes (including ropinirole, caffeine, clozapine, theophylline, tacrine, tizanidine): increased concentration of its substrates in the blood;
Probenecid: decreased excretion of norfloxacin;
Glibenclamide: development of severe hypoglycemia;
Antacids, didanosine, sucralfate, multivitamins containing zinc: decreased absorption of norfloxacin (the interval between their use should be at least 2 hours).

Analogues of Norfloxacin are: Loxon-400, Nolitsin, Norflok, Norbactin, Normax, Norilet, Sofasin, Negaflox.

Terms and conditions of storage

Store in a dry place, protected from light, out of reach of children at temperatures up to 25 °C.

Shelf life – 2 years.

Conditions for dispensing from pharmacies

Dispensed by prescription.

Tablet - 1 tablet:

Active substance: norfloxacin 400 mg;
Excipients: microcrystalline cellulose - 143 mg, croscarmellose sodium - 36 mg, povidone - 12 mg, colloidal silicon dioxide - 3 mg, magnesium stearate - 6 mg.
Film shell composition: hypromellose 9 mg, hyprolose - 3.49 mg, talc - 3.47 mg, titanium dioxide - 1.956 mg, yellow iron oxide - 0.084 mg.

Tablets 10 pieces.

Description of the dosage form

White or almost white, film-coated tablets, round, biconvex; on the fracture, two layers are visible - a white to light yellow core and a film shell.

pharmachologic effect

Antimicrobial synthetic agent of the fluoroquinolone group with a broad spectrum of action. Has a bactericidal effect. By suppressing DNA gyrase, it disrupts the process of DNA supercoiling.

Highly active against most gram-negative bacteria: Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Morganella morganii, Klebsiella spp. (including Klebsiella pneumoniae), Enterobacter spp., Serratia spp., Citrobacter spp., Yersinia spp., Providencia spp., Haemophilus influenzae, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Neisseria meningitidis.

Active against some gram-positive bacteria (including Staphylococcus aureus).

Anaerobic bacteria are resistant to norfloxacin; Enterococcus spp. are insensitive. and Acinetobacter spp.

Resistant to β-lactamases.

Pharmacokinetics

When taken orally, about 30-40% is absorbed; food intake reduces the rate of absorption. Plasma protein binding is 14%. Norfloxacin is well distributed in the tissues of the urogenital system. Penetrates through the placental barrier. About 30% is excreted unchanged in the urine.

Clinical pharmacology

Antibacterial drug of the fluoroquinolone group.

Indications for use Norfloxacin

Infectious and inflammatory diseases caused by microorganisms sensitive to norfloxacin.

For oral administration: diseases of the urinary tract, prostate gland, gastrointestinal tract, gonorrhea, prevention of relapses of urinary tract infections, bacterial infections in patients with granulocytopenia, "travelers' diarrhea."

For topical use: conjunctivitis, keratitis, keratoconjunctivitis, corneal ulcers, blepharitis, blepharoconjunctivitis, acute inflammation of the meibomian glands and dacryocystitis, prevention of eye infections after removal of a foreign body from the cornea or conjunctiva, after damage by chemical agents, before and after eye surgery; external otitis, acute otitis media, chronic otitis media, prevention of infectious complications during surgical interventions on the organ of hearing.

Contraindications for use of Norfloxacin

Pregnancy, lactation (breastfeeding), childhood and adolescence (up to 15 years), deficiency of glucose-6-phosphate dehydrogenase, hypersensitivity to norfloxacin and other quinolone drugs.

It should be used with caution in patients with epilepsy, convulsive syndrome of other etiologies, with severe impairment of renal and liver function.

Norfloxacin Use during pregnancy and children

Contraindicated in childhood and adolescence (up to 15 years).

Contraindicated for pregnant women and breastfeeding women, because The safety of the drug has not been studied.

Norfloxacin Side effects

From the digestive system: nausea, heartburn, anorexia, diarrhea, abdominal pain.

From the side of the central nervous system: headache, dizziness, feeling of fatigue, sleep disorders, irritability, anxiety.

Allergic reactions: skin rash, itching, Quincke's edema.

From the urinary system: interstitial nephritis.

Drug interactions

With simultaneous use of norfloxacin with warfarin, the anticoagulant effect of the latter is enhanced.

With simultaneous use of norfloxacin with cyclosporine, an increase in the concentration of the latter in the blood plasma is observed.

When taking norfloxacin simultaneously and antacids or drugs containing iron, zinc, magnesium, calcium or sucralfate, the absorption of norfloxacin is reduced due to the formation of complexons with metal ions (the interval between their administration should be at least 4 hours).

When administered concomitantly, norfloxacin reduces the clearance of theophylline by 25%; therefore, the dose of theophylline should be reduced when used concomitantly.

The simultaneous administration of norfloxacin with drugs that have the potential to lower blood pressure can cause a sharp decrease in blood pressure. In this regard, in such cases, as well as with the simultaneous administration of barbiturates and anesthetics, heart rate, blood pressure, and ECG indicators should be monitored. Concomitant use with drugs that lower the epileptic threshold can lead to the development of epileptiform seizures.

Reduces the effect of nitrofurans.

Dosage Norfloxacin

A single dose when taken orally is 400-800 mg, the frequency of use is 1-2 times a day. The duration of treatment is determined individually.

Precautionary measures

During the treatment period, patients should receive a sufficient amount of fluid (under the control of diuresis).

Norfloxacin should be taken at least 2 hours before or 2 hours after taking antacids or medications containing iron, zinc, magnesium, calcium or sucralfate.

Dosage form: The tablets are blue, round, biconvex, film-coated.

Before taking this medicine, read the entire leaflet carefully:

Do not throw away this leaflet. You may need to re-read it.

If you have any questions, ask your doctor or pharmacist.

This medicine must be prescribed to you by your doctor. Do not pass it on to others. It can harm them, even if their symptoms are the same as yours.

If any of the side effects become serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

What is Norfloxacin and what is it used for: Each tablet of Norfloxacin contains the active substance: 200 mg or 400 mg of norfloxacin and excipients: dibasic calcium phosphate, corn starch, lactose monohydrate, gelatin, talc, magnesium stearate, colloidal anhydrous silicon dioxide, sodium starch glycolate, propylene glycol, brilliant blue sancoate (hydroxypropyl methylcellulose, titanium dioxide, talc, polyethylene glycol 400), brilliant blue (E 133). This drug belongs to the group of quinolones, antimicrobial agents for systemic use. Suppresses the growth of microorganisms that cause infections.

Norfloxacin is used in the following cases: indicated for the treatment of infections caused by organisms sensitive to it.

Urinary tract infections:

uncomplicated urinary tract infections (including cystitis);

complicated urinary tract infections.

Sexually transmitted diseases:

uncomplicated urethral and cervical gonorrhea caused by Neisseria gonorrhea;

prostatitis.

Before starting treatment, it is necessary to determine the sensitivity of microorganisms to norfloxacin. Treatment with norfloxacin may be started before test results are available. In this case, before starting therapy, it is necessary to select material for laboratory diagnostics in order to be able to change treatment if the infectious agents are not sensitive to norfloxacin. To reduce the possibility of development of bacterial resistance and reduced effectiveness, norfloxacin should be used only to treat infections caused by pathogens that are sensitive to it.

Do not take Norfloxacin if:

hypersensitivity to norfloxacin, other quinolones or excipients of this drug;

liver failure;

end-stage chronic renal failure;

pregnancy and lactation;

childhood and adolescence (up to 18 years);

lactase deficiency, lactose intolerance, glucose-galactose malabsorption;

a history of tendonitis or tendon ruptures associated with treatment with quinolone derivatives.

When prescribing Norfloxacin, be sure to inform your doctor about taking any of the following medications; it is necessary to take into account their interaction when taken together:

Medicines with an established risk factor for prolongation of the QT interval on the ECG (class IA and III antiarrhythmic drugs, antidepressants, macrolides, antipsychotics). Risk of developing arrhythmias and prolongation of the QT interval on the ECG. ECG monitoring.

Nitrofurantoin. The drugs are antagonists; joint use is not recommended.

Probenecid. Reduces the excretion of norfloxacin by the kidneys, but does not affect its concentration in the blood.

Cyclosporine. It is possible to increase the concentration of cyclosporine in the blood serum. It is recommended to monitor the concentration of cyclosporine in the blood serum and, if necessary, dose adjustment.

Warfarin and its derivatives (phenprocoumon, acenocoumarol). Potentiation of the action of anticoagulants is possible. Laboratory monitoring of blood clotting parameters is recommended.

Hormonal contraceptives. The contraceptive effect may be reduced when taking norfloxacin. Additional methods of contraception are recommended during treatment.

Fenbufen. Concomitant use may provoke an epileptic attack; combination should be avoided.

Clozapine, ropinirole. When taking norfloxacin, a dose adjustment of clozapine or ropinirole may be necessary in patients already taking these drugs.

Glibenclamide. A sharp decrease in blood sugar is possible. Monitoring blood sugar levels is recommended.

Didanosine. Drugs may prevent one another from being absorbed. Didanosine is taken two hours after taking norfloxacin.

Nonsteroidal anti-inflammatory drugs (NSAIDs). The combination is used with caution; stimulation of the central nervous system with convulsive attacks is possible.

Antacids containing aluminum or magnesium hydroxide; preparations or products containing calcium salts (including milk salts), iron and zinc. Norfloxacin absorption is reduced. Norfloxacin should be taken 1-2 hours before or at least 4 hours after taking these drugs.

Theophylline. It is possible to increase the concentration of theophylline in the blood and develop side effects. It is recommended to monitor the concentration of theophylline in the blood and, if necessary, adjust the dose.

Antihypertensive drugs. A sharp decrease in blood pressure is possible. When taken simultaneously with drugs that lower the convulsive threshold of the brain (theophylline), epileptiform seizures occur.

Nitrofurans. Norfloxacin reduces the effect of nitrofurans.

Corticosteroid hormones. Increased risk of tendon rupture, especially in older patients.

Use of Norfloxacin during pregnancy and lactation: Contraindicated.

Impact on the ability to drive vehicles and operate machinery: The ability to drive a car and use other machinery may be reduced due to the effect of norfloxacin on reaction speed.

Directions for use and doses

Dosing for patients with normal renal function.

Uncomplicated urinary tract infections (cystitis): 400 mg 2 times a day, for 3-10 days.

Complicated urinary tract infections: 400 mg 2 times a day, for 10-21 days.

Sexually transmitted diseases: 800 mg once.

Prostatitis (acute, chronic): 400 mg 2 times a day, for 28 days.

Dosing in patients with renal impairment:

In patients with a creatinine clearance of 30 ml/min/1.73 m 3 or less, the recommended dose is 400 mg once daily for the duration of treatment indicated above.

With a known level of creatinine clearance, the following formula is used to calculate the dose (taking into account the gender, weight and age of the patient):

Men =

Women =(0.85) x (higher value)

Elderly patients. With normal renal function, no dose adjustment is required.

Possible side effects:

From the cardiovascular system: prolongation of the QT interval on the ECG, ventricular arrhythmia.

From the gastrointestinal tract: vomiting, heartburn, pancreatitis.

From the nervous system: dizziness, hallucinations, mood changes, sensory disturbances, insomnia, depression, anxiety, irritability, euphoria, disorientation, anxiety, polyneuropathy, including Guillain-Barré syndrome, seizures, mental disorders, tremor, twitching of large muscles.

From the hematopoietic system: decrease in the number of neutrophils, platelets in the blood, anemia.

From the urinary system: inflammation of the kidney.

From the musculoskeletal system and connective tissue: joint pain, inflammation of ligaments/tendons, tendon ruptures, muscle pain, arthritis, very rarely - inflammation of the Achilles tendon and rupture.

From the skin and subcutaneous tissue: skin itching, swelling, rashes, minor hemorrhages, hemorrhagic bullae and papules with crust formation as a manifestation of vascular damage.

From the immune system: angioedema; in isolated cases - exfoliative dermatitis, Stevenson-Johnson syndrome, Lyell's syndrome, exudative polymorphic erythema, photosensitivity.

Changes in laboratory parameters: increased levels of glutomat-oxaloacetate transaminase,

glutamate-pyruvate transaminase, alkaline phosphatase in the blood.

Others: vaginal candidiasis, increased lacrimation, ringing in the ears, hearing loss, shortness of breath, taste disorders.

If you take a higher dose of Norfloxacin than your doctor recommends: If the number of tablets you take per day exceeds the number recommended by your doctor, or your child swallows tablets, consult a doctor or call an ambulance! Stop taking the medicine! An overdose may include dizziness, headache, fatigue, convulsions, hallucinations, confusion, abdominal discomfort, impaired kidney and liver function, and the presence of crystals and blood in the urine. As first aid, it is recommended to rinse the stomach and take antacids.

Precautions and special instructions when taking Norfloxacin:

Hypersensitivity. After taking a single dose of the drug, hypersensitivity reactions are possible, including anaphylactic and anaphylactoid reactions, life-threatening conditions. Stop taking the medicine immediately, inform your doctor immediately or call an ambulance!

Pseudomembranous colitis. If you suspect pseudomembranous colitis (loose stools for a long time, possibly with blood or mucus in it), you should immediately stop taking it and immediately consult a doctor for appropriate treatment! You should not use medications that inhibit intestinal motility.

Central nervous system. It is known that quinolones can lower the seizure threshold and initiate seizures. Use with caution in patients with central nervous system diseases that provoke seizures. Cases of polyneuropathy (pain, burning, anxiety, tinnitus, muscle weakness, sensitivity disorders, including tactile, pain, temperature, vibration and muscle-articular) have been reported. If these phenomena occur, stop taking the drug! Inform your doctor immediately!

The cardiovascular system. Since the use of norfloxacin is associated with cases of prolongation of the QT interval on the ECG, caution must be exercised when treating patients at risk of developing arrhythmia: congenital prolongation of the QT interval; simultaneous use of class IA and III antiarrhythmic drugs, antidepressants, macrolides, antipsychotics; electrolyte disturbances; women and elderly patients are more sensitive; heart diseases.

Musculoskeletal system. Norfloxacin should not be used in patients with tendon diseases or disorders from previous use of quinolones. If it is necessary to treat severe infectious diseases in such patients, a microbiological study and assessment of the risk-benefit ratio are carried out. Inflammation or tendon rupture may occur, especially in elderly patients or those concomitantly taking corticosteroids. If there are any signs of this disease (swelling, inflammation), stop taking the drug and immobilize the affected limb. Use with caution in patients with myasthenia gravis.

Photosensitivity. Patients taking norfloxacin should avoid direct exposure to sunlight and UV radiation.

Syphilis. Norfloxacin is not indicated for the treatment of syphilis. Antimicrobial drugs used in high doses for a short period of time to treat gonorrhea may mask or delay the onset of symptoms of developing syphilis. All patients with gonorrhea should undergo a serological test for syphilis at the time of diagnosis, and again (3 months later) after the prescription of norfloxacin.

Surgical reactions. Warn your doctor about taking norfloxacin: monitoring the state of the blood coagulation system is recommended (an increase in the prothrombin index is possible).

Glucose-6-phosphate dehydrogenase deficiency. The development of hemolytic reactions is possible. The drug is not prescribed to such patients, except in cases where the potential benefit outweighs the possible risk.

Excipients. Do not take in cases of congenital galactose intolerance and Lapp lactase deficiency or malabsorption of glucose and galactose (contains lactose).

General information. Use with caution for atherosclerosis of cerebral vessels, cerebrovascular accidents, epilepsy and convulsive syndrome, impaired renal and liver function.

Storage conditions:

Store in a place protected from moisture and light, at a temperature not exceeding 25°C. Keep out of the reach of children.

Best before date:

3 years. Do not use the medicine after the expiration date.

Vacation conditions:

By doctor's prescription.

Package:

10 or 20 tablets in polymer jars. 1 can along with an insert in a pack.

10 tablets in a blister pack. 1 or 2 blister packs in a pack.

Manufacturer information:

Produced by: “Belarusian-Dutch joint venture limited liability company “Farmland” (JV LLC “Farmland”), Republic of Belarus, Nesvizh, st. Leninskaya, 124 – 3.

Content

For urinary tract infections and other diseases of the genitourinary system, doctors prescribe the drug Norfloxacin. This drug is an effective broad-spectrum antibacterial drug and can only be used as prescribed by a specialist strictly in accordance with the prescribed dosage and dosage regimen.

Instructions for use of Norfloxacin

A broad-spectrum drug, Norfloxacin belongs to the pharmacological group of fluoroquinolones - substances with antibacterial activity. The product is used:

in urological practice – for the treatment and prevention of relapses of acute and chronic infectious and inflammatory diseases of the genitourinary system;
in ophthalmology;
otolaryngology.

Composition and release form

The drug Norfloxacin is available in the form of tablets for oral administration and drops (for instillation into the eyes or ears). One tablet (yellow, biconvex, oblong, with a score on one side and rounded ends) contains 200 or 400 mg of the main active substance - norfloxacin. The product is packaged in blisters of 10 pieces, 1-2 blisters per package, with instructions for use included. General composition of the drug in different dosage forms:

Pharmacological properties

The synthetic drug Norfloxacin from the pharmacological group of fluoroquinolones has pronounced antibacterial activity and a wide spectrum of action. The main component destabilizes the DNA chain in the bacterial cell, which leads to its death. Insensitive to norfloxacin are: a number of anaerobic bacteria (peptococci, clostridia), nocardia, treponema pallidum. The product is active against the following pathogenic microorganisms:

gram-negative bacteria - salmonella, gonococci, chlamydia, escherichia, klebsiella, shigella, enterobacteria, hemophilus influenza;
gram-positive bacteria - staphylococci, streptococci.

Norfloxacin - is it an antibiotic or not?

The drug Norfloxacin is not classified as an antibiotic, although its main component exhibits antibacterial and antiseptic activity. The pharmacological group of fluoroquinolones is close to antibiotics in terms of spectrum and mechanism of action, but unlike antibacterial drugs, fluoroquinolones have no natural analogues, that is, they differ in origin. In addition, these substances have a different structure.

Indications for use of Norfloxacin

The use of Norfloxacin in medical practice is associated with the treatment and prevention of infections of the urinary organs and reproductive system, inflammation of the uterus and appendages, eye and ear infectious diseases of bacterial etiology. Oral tablets are prescribed for:

pyelonephritis;
cystitis;
urethritis;
prostatitis;
inflammation of the bladder or ureters;
gonorrhea;
chlamydia;
salmonellosis;
cervicitis;
endometritis;
bacterial infection in patients with granulocytopenia;
"traveler's diarrhea"

Local use is indicated in connection with the prevention of infection during diagnostic procedures and surgical interventions in urological practice, plus for the following eye and ENT diseases:

Directions for use and dosage

The dosage regimen and duration of treatment depend on the picture of the disease and are selected individually in each specific clinical case. If there is no positive dynamics or the condition worsens after a week of use, you should contact your doctor to adjust the dosage or select a replacement drug. In some cases, if there is no improvement, clarification of the type of infectious agent is required.

According to the manufacturer's recommendation, Norfloxacin tablets are taken without chewing, with a glass of water, regardless of meals, two to three times a day, 400 mg per dose. The duration of the course depends on the diagnosis and is:

for cystitis – twice a day for 7–12 days;
for urinary tract infections – 3–7 days; in case of chronic relapsing nature of the disease - in a reduced dosage for 2-3 months;
for gastroenteritis – 3–5 days;
for cervicitis, urethritis, proctitis or pharyngitis - 800 mg at a time, once;
during typhoid fever - three times a day for two weeks;
for the prevention of sepsis - twice a day;
against relapses of chronic infections - 200 mg once a day for 12–14 days.

Local use of Norfloxacin in the form of drops is indicated for diseases of the eyes and ears, acute or chronic otitis media, conjunctivitis, and infectious blepharitis. For an uncomplicated course, 2 drops are prescribed in the affected eye or ear, 3-4 times a day, and one drop in an uninfected eye, for prevention purposes. With a high degree of infection, the dose may be increased by the attending physician depending on the patient’s condition and the severity of symptoms.

special instructions

During therapy with the drug, it is recommended to increase the amount of daily fluid intake. Care must be taken when driving vehicles and performing work associated with increased concentration of attention, requiring prompt psychomotor reactions. An increase in the prothrombin index is possible; in this regard, during surgical interventions, constant monitoring of the level of blood clotting is required.

During pregnancy

Clinical studies on mammals of various groups have revealed an increase in the likelihood of developing fetal pathologies when the mother takes the drug Norfloxacin during pregnancy. The active component can penetrate the placental barrier, so the use of the drug is contraindicated at any time. The substance is excreted in breast milk, so breastfeeding should be suspended during treatment and use of this medication.

In childhood

Due to the fact that the effect of the active component of the drug on an incompletely formed organism has not been studied well, the drug Norfloxacin is not prescribed to children or adolescents under eighteen years of age. In case of urgent need, it can be prescribed to children over 14 years of age - in a reduced dosage and only by the decision of the attending physician.

Drug interactions

When used simultaneously with drugs from other pharmacological groups, Norfloxacin may reduce their concentration or absorption and provoke the development of side effects. This is taken into account when prescribing the drug. Taking the product:

reduces the clearance of Theophylline;
increases the concentration of indirect anticoagulants in the blood serum;
slows down the pharmacological activity of nitrofurans;
when taken simultaneously with drugs that lower the epileptic threshold, the risk of developing epileptic seizures increases;
when taken simultaneously with drugs that lower blood pressure, a sharp decrease in blood pressure is possible;
When taking barbiturates and general anesthesia, monitoring of pulse, blood pressure and stability of the heart is necessary.

Side effects

Those taking Norfloxacin may develop the following side symptoms and phenomena associated with the individual characteristics of the patient’s body or exceeding the recommended dosage:

from the digestive system - nausea or vomiting, loss of appetite, diarrhea, dyspeptic disorders;
urinary system – glomerulonephritis, polyuria, hypercreatininemia, albuminuria, crystalluria;
nervous system - fainting and dizziness, insomnia or drowsiness, hallucinations.
sensory organs - visual impairment, burning in the eyes, photophobia, conjunctival hyperemia;
cardiovascular system – vasculitis, tachycardia, arrhythmia;
hematopoietic organs – decreased number of blood leukocytes, decreased hematocrit, eosinophilia;
other side effects – candidiasis; urticaria, skin itching and other allergic reactions; swelling; Stevens-Johnson syndrome (erythema malignant vascularis); arthralgia.

Overdose

If the doses recommended by the doctor and the manufacturer are exceeded, an overdose is possible, accompanied by side effects and the development of liver failure. A disturbance in the water-electrolyte balance in the body is noted against the background of vomiting or severe diarrhea and confusion. As treatment, gastric lavage is performed and enterosorbents are prescribed. There is no universal antidote.

Contraindications

Norfloxacin is contraindicated during pregnancy and breastfeeding (if it is necessary to undergo a course of treatment, feeding is stopped), in patients under eighteen years of age (in some cases, it can be prescribed to children over 14 years of age). Other contraindications are:

lack of glucose-6-phosphate dehydrogenase;
hypersensitivity to the components of the drug;
Can be used with caution in cases of cerebral atherosclerosis, epileptic syndrome, diabetes mellitus, impaired renal or liver function.

Terms of sale and storage

A prescription may be required at time of purchase. Stored for two years from the date indicated on the packaging at a temperature not exceeding 25°C, out of the reach of children.

Analogs

If individual intolerance to one of the components is detected or there is no clinical effect, the attending physician may replace the drug with its analogue based on the mechanism of action or the main active substance. Such drugs include:

Nolicin is a structural analogue, produced on the basis of the same active component, with a similar mechanism of action. Intended for oral administration for the treatment of diseases of the genitourinary system of an infectious-bacterial nature.
Norbactin is an antibacterial drug with a broad spectrum of action, a potent antipseudomonal agent.
Sophasin is a drug from the pharmacological group of fluoroquinols with a similar active substance and mechanism of action.

Norfloxacin price

You can purchase the drug in pharmacies; when purchasing, the pharmacist may ask you to present a medical prescription (prescription). The price range in Moscow pharmacies for all dosage forms of the drug can be found in the table below.