home Analyzes What kind of drug is ranitidine? Ranitidine - instructions for use, advantages of the medication, drugs similar in action and reviews. Negative Side Effects

What kind of drug is ranitidine? Ranitidine - instructions for use, advantages of the medication, drugs similar in action and reviews. Negative Side Effects

Ranitidine is an antiulcer drug that is used for gastrointestinal diseases.

The instructions for use of the medication state that the product helps with stomach pain. Able to block receptors of cells in the lining of the gastric mucosa. The medicine creates favorable conditions for normal functioning and what these tablets do is help reduce the volume of secretion.

In this article we will look at why doctors prescribe Ranitidine, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Ranitidine can be read in the comments.

Composition and release form

Clinical and pharmacological group: histamine H2 receptor locator. Antiulcer drug.

Each tablet contains the active substance: ranitidine hydrochloride – 168 mg, in terms of ranitidine – 150 mg.
Excipients (core): microcrystalline cellulose 83.76 mg, potato starch - 28.0 mg, magnesium stearate - 3.0 mg, colloidal silicon dioxide - 1.0 mg, povidone (polyvinylpyrrolidone) - 16.24 mg.

What is Ranitidine used for?

The main medical indication for taking Ranitidine tablets is the need to reduce the acidity of gastric juice in various pathological processes of the digestive system:

for stomach and duodenal ulcers associated with frequent, prolonged or uncontrolled use of non-steroidal anti-inflammatory drugs;
for the treatment and prevention of exacerbations, ulcerative lesions of the stomach and duodenum (peptic ulcer);
for the treatment of reflux esophagitis, erosive esophagitis;
with Zollinger-Ellison syndrome;
for the prevention and treatment of postoperative or “stress” stomach ulcers;
to prevent recurrence of gastric or esophageal bleeding.

It is also used to prevent aspiration of gastric juice during surgical interventions under anesthesia (with Mendelssohn syndrome).

pharmachologic effect

Ranitidine is an antiulcer drug that belongs to the group of histamine H2 receptor antagonists. It selectively blocks histamine H2 receptors in the parietal cells of the gastric mucosa and inhibits the secretion of hydrochloric acid.

Under the influence of Ranitidine, the total volume of secretion also decreases, which leads to a decrease in the amount of pepsin in the stomach contents. The antisecretory effect creates favorable conditions for the healing of stomach and duodenal ulcers.

Ranitidine increases protective factors in the tissues of the gastroduodenal zone: enhances reparative processes, improves microcirculation, and increases the secretion of mucous substances.

Instructions for use

Ranitidine tablets are taken orally, regardless of food. Do not chew them and wash them down with plenty of water. Dosage and regimen for adults and children over 12 years of age depends on the indications:

Peptic ulcer with predominant localization of pathological defects in the stomach and duodenum - 150 mg (0.15 g) 2 times a day (usually morning and evening) or 300 (0.3 g) mg 1 time a day at night. If necessary, the dose can be increased to 0.3 g 2 times a day (daily dose 0.6 g). Duration of use is from 4 to 8 weeks. To prevent exacerbation of this pathology, Ranitidine tablets are taken in a dosage of 0.15 g once a day. Since nicotine enhances the production of hydrochloric acid, for smokers the preventive dose is increased to 0.3 g once a day.
Ulcers resulting from the use of non-steroidal anti-inflammatory drugs - 0.15 g 2 times a day or 0.3 g 1 time a day at night, course of therapy is 8-12 weeks.
Zollinger-Ellison syndrome. The initial dose is 150 mg 3 times a day; if necessary, the dose can be increased.
Prevention of bleeding from defects, erosions or ulcers - 0.15 g in the morning and evening.
Prevention of the development of Mendelssohn's syndrome. Prescribed at a dose of 150 mg 2 hours before anesthesia, and preferably 150 mg the night before.
Treatment of “stress” ulcers of the stomach or duodenum - 0.15 g in the morning and evening, duration of therapy is 4-8 weeks.
Erosive reflux esophagitis. Prescribe 150 mg 2 times a day or 300 mg at night. If necessary, the dose can be increased to 150 mg 4 times / day. The course of treatment is 8-12 weeks. Long-term preventive therapy – 150 mg 2 times a day.

If there is concomitant liver dysfunction, a dose reduction may be necessary. For patients with renal failure with CC less than 50 ml/min, the recommended dose is 150 mg/day.

Contraindications

Ranitidine is contraindicated in case of hypersensitivity to the components of the drug or liver cirrhosis. The drug Ranitidine is not used in pregnant women or during lactation. Also, Ranitidine is not prescribed to children under twelve years of age.

Adverse reactions

Adverse reactions are extremely rare when taken:

Abnormal stool; dry mouth.
Nausea and vomiting.
Heart rhythm disturbances and abdominal pain.
Sleep problems and headaches.
Frequent mood changes.
Reduced visual acuity and image distortion.
Decreased potency or libido.
Skin rash and itching.
Swelling, including Quincke's edema.
Bronchospasms, similar to asthmatic attacks.

Women who take the drug for a long time may experience cessation or failure of menstruation. In men, impotence and breast enlargement are possible. As a result, the drug must be taken as prescribed by the doctor and only as prescribed.

special instructions

Since Ranitidine therapy can mask the symptoms of malignant diseases of the gastrointestinal tract, before starting the course it is necessary to exclude the possibility of cancer of the stomach, esophagus or duodenum.

Analogs

Analogs of the drug include the following drugs: Zoran, Ranisan, Gistak, Rantak, Ranitidine-Acri, Ulran, Atsilok, Ranitidine-Akos, Ranigast, Zantin, Ranitidine-Ferein, Ranitin, Ulkodin.

Prices

The average price of Ranitidine in pharmacies (Moscow) is 25 rubles.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

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Why is Ranitidine prescribed by doctors? Before answering the question, you should find out what this drug is, what composition it has, how it should be taken and in what dosages?

General information

What can Ranitidine be taken for? Such a synthetic drug is one that can significantly reduce the volume of gastric juice.

Composition of the drug and its release form

The drug "Ranitidine" is available in the following dosage forms:

Tablets that contain 300 mg and 0.15 g of the active ingredient (ranitidine in the form of hydrochloride). This medication goes on sale in 100, 30 or 20 pieces in cardboard packaging.
Injection. This drug is used only when oral administration of the medication is impossible for some reason. The medicinal solution is sold in ampoules of 2 ml.

Pharmacodynamics

Why is Ranitidine so often prescribed by doctors? This drug, or rather its active component, quite quickly reduces the volume of gastric juice, the secretion of which is caused by stretching of the main digestive organ. As a rule, this pathological condition occurs due to excessive food load, as well as under the influence of certain biogenic stimulants (histamine, acetylcholine, gastrin, pentagastrin and caffeine) and hormones.

After using the drug "Ranitidine", the patient's protection of the mucous membrane of the main digestive organ is enhanced, and the amount of hydrochloric acid in its juice is noticeably reduced. It should be especially noted that when using this drug, mucus production practically does not change and the enzymatic functions of the liver are not suppressed.

The drug "Ranitidine" promotes the healing and restoration of all damage to the gastric mucosa that is associated with the effects of hydrochloric acid. This effect of the drug is due to an increase in the formation of stomach mucus. According to the instructions, the drug "Ranitidine" in a dose of 0.15 g suppresses the secretion of juice of the main digestive organ for 8-13 hours.

What is Ranitidine prescribed for?

This drug is used for the following deviations:

ulcer of the duodenum and stomach (especially in the acute stage);
inflammation of the esophagus, which is caused by the reflux of stomach contents into it (with reflux esophagitis);
inflammation of the esophagus due to a violation of the integrity of its mucous membrane (with;
for symptomatic and rapidly developing ulcers of the duodenum and stomach resulting from stress, taking certain medications or certain diseases of the internal organs;
stomach ulcers in combination with a benign pancreatic tumor (with Zollinger-Ellison syndrome).

Use for prevention

The drug "Ranitidine" for the stomach is taken not only for treatment, but also for the prevention of the following abnormalities:

exacerbations of ulcerative and erosive diseases;
lesions of the upper gastrointestinal tract;
entry of stomach juice into the respiratory tract during surgery (under anesthesia).

Contraindications for use

Ranitidine stomach tablets should be taken only after consulting a doctor. After all, this drug has some contraindications:

pregnancy;
in childhood (up to 14 years);
increased sensitivity to the drug;
lactation period.

Also, the drug "Ranitidine" is prescribed with extreme caution in case of disorders of the excretory function of the kidneys.

Dosage and methods of application

The presented drug is prescribed in one dosage or another depending on the diagnosis:

To prevent stress ulcerations and bleeding, Ranitidine should be used intramuscularly or intravenously at 0.1 or 0.05 g every 7-8 hours.

Side effects

This drug may cause the following side effects:

skin rash;
dizziness;
thrombocytopenia;
headache;
fatigue.

In rare cases, the drug "Ranitidine" provokes hair loss. Also, the presented drug can lead to hallucinations and the development of confusion. With long-term use of large doses, the patient's prolactin levels increase, gynecomastia, leukopenia, impotence, amenorrhea occur, and libido decreases. Sometimes the use of such a drug can lead to the development of hepatitis.

special instructions

This drug is prescribed with extreme caution to patients with severe impairment of the kidneys or liver.
Before starting treatment with this remedy, the possible presence of a malignant disease of the stomach, esophagus or duodenum should be excluded.
In case of urgent need to discontinue therapy, the medication is discontinued by gradually reducing the dose.
The effectiveness of preventive use of the drug in courses of 50 days in the autumn-spring period is much higher than with its constant use.

Analogues of the product

Analogs of this medication are the drugs “Zantac”, “Rantak”, “Ranisan”, “Acylok”, “Ulran”, “Ulkodin”, “Ranigast” and “Ranidine-Akos”. What are all these remedies taken for? They contain the same active component, and therefore the indications for such drugs are identical.

Ranitidine: instructions for use and reviews

Latin name: Ranitidin

ATX code: A02BA02

Active substance: ranitidine

Manufacturer: Tyumen Chemical and Pharmaceutical Plant (Russia), Severnaya Zvezda CJSC (Russia), Ozon LLC (Russia), AVEXIMA OJSC (Russia), Sopharma (Bulgaria), Hemofarm (Serbia), Shreya Life Sciences ( India), Panacea Biotec (India), JAKA-80 (Macedonia), FC "Zdorovye" (Ukraine), Mapichem (Switzerland) and others

Updating the description and photo: 14.08.2019

Ranitidine is an antiulcer drug that blocks H2-histamine receptors.

Release form and composition

Dosage form – film-coated tablets: round, biconvex, light orange in color (in blisters of 10 tablets, 2 blisters in a cardboard box).

Active ingredient: ranitidine (in the form of hydrochloride) – 150 or 300 mg per tablet.

Auxiliary components: Kollidon VA-64, corn starch, colloidal silicon dioxide, propylene glycol, polyethylene glycol 6000, sodium lauryl sulfate, hypromellose, magnesium stearate, ethylcellulose, microcrystalline cellulose, titanium dioxide, sunset yellow dye.

Pharmacological properties

Pharmacodynamics

Ranitidine is a blocker of histamine H2 receptors on parietal cells that make up the gastric mucosa. It suppresses basal and stimulated production of hydrochloric acid due to dietary load, baroreceptor irritation and the effects characteristic of biogenic stimulants (pentagastrin, gastrin, histamine) and hormones. Ranitidine helps reduce the volume of gastric juice and the concentration of hydrochloric acid in it and increases the pH of the stomach contents. This explains the reduced activity of pepsin during treatment with the drug. The duration of its action after a single dose is about 12 hours.

Pharmacokinetics

When taken orally, the bioavailability of ranitidine is approximately 50%. The substance binds to plasma proteins by no more than 15% and is partially involved in metabolic processes occurring in the liver. Its maximum content in plasma is achieved 2 hours after taking the tablets. The half-life of ranitidine is 2–3 hours. Approximately 30% of the dose taken is excreted unchanged through the kidneys, and a small amount of ranitidine is excreted through the intestines. The substance penetrates the placental barrier and is detected in breast milk.

Indications for use

Exacerbation of gastric ulcer and duodenal ulcer (treatment and prevention);
Zollinger-Ellison syndrome;
Erosive esophagitis and reflux esophagitis;
Gastric and duodenal ulcers that developed as a result of taking non-steroidal anti-inflammatory drugs (NSAIDs);
Postoperative and stress ulcers of the upper gastrointestinal tract (treatment and prevention);
Prevention of Mendelssohn's syndrome (aspiration of gastric juice) during operations using general anesthesia;
Prevention of recurrent bleeding from the upper gastrointestinal tract.

Contraindications

Absolute:

Children under 12 years of age;
Pregnancy and lactation period;
Individual hypersensitivity to the components of Ranitidine.

Relative:

Liver cirrhosis with a history of portosystemic encephalopathy;
Liver and/or renal failure;
Acute porphyria, including a history of

Instructions for use of Ranitidine: method and dosage

Ranitidine tablets should be taken orally: swallowed whole with plenty of liquid. Eating does not affect the effectiveness of the drug.

Peptic ulcer of the stomach and duodenum: treatment of exacerbations - 150 mg in the morning and evening or 300 mg at night, in some cases it is possible to increase the dose to 300 mg 2 times a day, course of treatment - from 4 to 8 weeks; prevention of exacerbations - 150 mg 1 time per day at night, for smoking patients - 300 mg at night;
Peptic ulcer due to taking NSAIDs: treatment - 150 mg morning and evening or 300 mg at night for a course of 8-12 weeks; prevention – 150 mg morning and evening;
Postoperative and stress ulcers: 150 mg 2 times a day for 4-8 weeks;
Zollinger-Ellison syndrome: 150 mg 3 times a day, increase the dose if necessary;
Erosive reflux esophagitis: 150 mg morning and evening or 300 mg at night, in some cases the doctor may increase the dose to 150 mg 4 times a day, duration of therapy is 8-12 weeks. If long-term preventive therapy is necessary, 150 mg is prescribed 2 times a day;
Prevention of recurrent bleeding from the upper gastrointestinal tract: 150 mg 2 times a day;
Prevention of Mendelssohn's syndrome: 150 mg in the evening before surgery, then 150 mg 2 hours before anesthesia.

In case of renal failure (creatinine clearance less than 50 ml/minute), the daily dose should not exceed 150 mg.

Patients with concomitant liver dysfunction may also require a reduction in the daily dose.

Side effects

Allergic reactions: bronchospasm, skin rash, urticaria, anaphylactic shock, Quincke's edema, erythema multiforme;
From the cardiovascular system: atrioventricular block, bradycardia, decreased blood pressure, arrhythmia;
From the musculoskeletal system: myalgia, arthralgia;
From the nervous system: headache, drowsiness, dizziness, increased fatigue; rarely - tinnitus, involuntary movements, irritability, confusion, hallucinations (more often in older people and seriously ill patients);
From the hematopoietic organs: bone marrow hypo- and aplasia, agranulocytosis, immune hemolytic anemia, thrombocytopenia, leukopenia, pancytopenia;
From the digestive system: dry mouth, abdominal pain, diarrhea/constipation, nausea and/or vomiting; rarely - acute pancreatitis, cholestatic, hepatocellular or mixed hepatitis;
From the endocrine system: amenorrhea, gynecomastia, decreased libido, hyperprolactinemia, impotence;
From the senses: accommodation paresis, blurred visual perception;
Other: hypercreatininemia, alopecia.

Overdose

In case of an overdose of Ranitidine, the following symptoms may be observed: ventricular arrhythmias, bradycardia, convulsive seizures. In this case, symptomatic therapy is recommended, as well as gastric lavage and/or induction of vomiting. If seizures occur, diazepam is administered intravenously. For bradycardia, atropine is prescribed, and for ventricular arrhythmias, lidocaine is prescribed. Hemodialysis is considered an effective procedure for removing ranitidine.

special instructions

Due to the fact that Ranitidine can mask symptoms characteristic of gastric carcinoma, the presence of oncology must be excluded before prescribing it.

During the period of therapy, it is recommended to refrain from drinking drinks, food and medications that can irritate the gastric mucosa, as well as from driving a car and performing potentially dangerous work that requires speed of psychophysical reactions and increased attention.

In weakened patients, with prolonged use of the drug under stress, bacterial gastric lesions are possible with subsequent spread of infection.

Like all H2-histamine blockers, Ranitidine should not be discontinued abruptly (there is a risk of developing rebound syndrome).

If simultaneous use is necessary, histamine H2 receptor blockers should be taken 2 hours after taking ketoconazole/itraconazole, otherwise their absorption may be significantly reduced.

According to the instructions, Ranitidine can increase the activity of glutamate transpeptidase.

There is some evidence that the drug can cause acute attacks of porphyria.

Histamine H2 receptor blockers can counteract the effect of histamine and pentagastrin on the acid-forming function of the stomach, so their use is not recommended within 24 hours before the test.

During treatment with Ranitidine, it is possible to obtain a false-positive reaction when testing for the presence of protein in the urine.

Because histamine H2 receptor blockers may suppress the skin reaction to histamine, they should be discontinued before diagnostic skin testing is performed to detect an immediate allergic skin reaction.

Drug interactions

Please note that ranitidine:

Inhibits the metabolism in the liver of indirect anticoagulants, calcium antagonists, aminophenazone, glipizide, diazepam, lidocaine, metronidazole, propranolol, phenazone, theophylline, hexobarbital, buformin, aminophylline, phenytoin;
Increases serum concentration and half-life of metoprolol;
Reduces the absorption of ketoconazole and itraconazole.

Smoking reduces the effectiveness of ranitidine.

With the simultaneous use of drugs that have an inhibitory effect on the bone marrow, the risk of developing neutropenia increases.

Antacids and sucralfate in high doses may slow down the absorption of ranitidine, so a minimum of 2-hour intervals should be maintained between doses.

Analogs

Analogs of Ranitidine are: Ranitidine Sopharma, Acylok, Ranisan, Ranitidine-LekT, Zantac, Ranitidine-AKOS, Gistak, Zoran, Ranitidine-Ferein, Ulran.

Terms and conditions of storage

Store in a dry place, out of reach of children, at a temperature of 15-30 °C.

Shelf life – 3 years.

Ranitidine - this drug is in great demand in the modern pharmaceutical market. This medicine is used as part of complex therapy in the treatment of duodenal or gastric ulcers. Systematic use of Ranitidine significantly accelerates the healing process of damaged areas of the gastrointestinal mucosa, due to increased secretion of mucus in the stomach and duodenum. The secreted mucus acts as a kind of “barrier” between the contents of this organ and its mucous membrane. Also, this secretion envelops the emerging defects - ulcers, due to which their recovery, and, consequently, the patient’s recovery is significantly accelerated.

This drug significantly reduces the secretory function of the stomach, as a result of which the volume of gastric juice secreted and the level of hydrochloric acid decreases - and, as is known, these factors are the main cause of gastritis or heartburn. In the content of this article you will learn: “What is Ranitidine taken for? How to use this drug correctly, and what are the contraindications for taking it? - and many other interesting facts about this medicine.

What substances are included in this medicine, the form of release of the drug

The main active ingredient that is part of this medication is ranitidine hydrochloride. This medicine is available in the form of tablets and solution for injection.

The tablets contain 0.15 g (150 mg) or 0.30 g (300 mg) of the active substance. The medicine is available in cardboard packages of 20-30-100 pieces. As for the injection solution of ranitidine hydrochloride, it is used in this form relatively rarely, only when internal use of the drug is not possible. Ranitidine in injection form is sold in pharmacies in ampoules containing 2 ml of medicinal solution.

Mechanism of action of the drug

The main active component of the drug significantly reduces the volume of digestive juice secreted by the stomach, the secretion of which can increase due to stretching of the walls of this organ due to food load (one-time intake of a large amount of food). Also, the increase in secretory function of the gastrointestinal tract is influenced by the action of certain hormones and biogenic stimulants, for example: acetylcholine, histamine, pentagastrin, gastrin and caffeine.

With regular use of Ranitidine tablets, the protection of the mucous membrane of the causative organ is significantly improved, and the content of hydrochloric acid in the digestive juice of the stomach decreases. At the same time, the number of “liver” enzymes does not change and mucus production is not suppressed.

This medicine promotes the most rapid healing and restoration of the affected areas of the gastric and duodenal mucosa, reducing the risk of the formation of new ulcers. As mentioned earlier, the healing effect after taking this medication is due to an increase in the production of one’s own gastric mucus. According to the instructions for use of this drug, when taking Ranitidine at the indicated therapeutic dose (150 mg), the production of gastric juice in the body is suppressed within 8-12 hours.

For what conditions is this medication indicated?

What is Ranitidine taken for? This drug can be used as part of complex treatment for the following diseases:

with Zollinger-Ellison syndrome;
with exacerbation of peptic ulcer of the stomach and duodenum;
with reflux esophagitis.

In what other cases can this medicine be used? Ranitidine is also successfully used for heartburn, since the components included in this medicine reduce acidity levels in the stomach.

For preventive purposes, the drug is prescribed after surgical interventions to prevent the development of relapses of ulcers. This medicine also reduces the risk of bleeding in the gastrointestinal tract after surgery, and relieves any pain in the epigastric area.

How to take Ranitidine correctly?

This medicine in tablet form can be used from the age of 12. This medicine is used regardless of food intake, so you can take this drug at absolutely any time. Ranitidine tablets are taken without chewing and with the required amount of liquid.

The dose of this medication is determined by the treating specialist individually for each patient, depending on the diagnosis:

In the event of exacerbations of a gastric or duodenal ulcer, the patient is prescribed to take 1 tablet (150 mg) of ranitidine hydrochloride 2 times a day, in the morning and evening, or 1 tablet (300 mg) in a single dose.
When postoperative and “stress” ulcers appear, it is recommended to use this drug in the amount of 1 tablet (150 mg) 2 times a day. The course of treatment takes from 1 to 2 months.
To treat a pathology such as reflux esophagitis, this medication is taken in the following dosage: in the evening and morning hours, take 150 mg of the drug, or a one-time dose of 300 mg. The treatment course in this case ranges from 2-4 weeks to 2 months.
In order to prevent ulcers of the duodenum or stomach and prevent bleeding of the mucous membrane of the affected organ, drink 1 tablet (150 mg) of Ranitidine twice a day - morning and evening.
If a patient develops Zollinger-Ellison syndrome, it is recommended to use this drug in the amount of 1 tablet (150 mg) per day.

This medication is also used before surgical interventions on the gastrointestinal tract to prevent the development of Mendelssohn's syndrome. The patient takes 1 tablet (150 mg) of Ranitidine on the eve of surgery, and immediately 1.5-2 hours before surgery.

This medicine is effective not only as part of complex therapy, it is also recommended to be used for the symptomatic treatment of various disorders of the stomach and duodenum - for example, Ranitidine is good for heartburn. If the patient develops symptoms of renal failure, the dosage of the drug should be halved.

Main contraindications

This medicine is not recommended for pregnant, lactating women and children under 3 years of age for the simple reason that there is no reliable information about the negative effects of Ranitidine on the body of these categories of the population. The medicine is also prohibited for use by patients with reduced stomach acidity and insufficient amounts of digestive enzymes produced. As a result of self-administration of the drug, severe symptoms may develop, so the use of Ranitidine should be agreed upon with a qualified specialist.

If the patient develops symptoms of kidney or liver failure, this medication should only be used under medical supervision or should be completely discontinued. Sometimes in such a situation, the doctor may recommend reducing the dosage of this drug.

For severe diseases of the liver and nervous system of the body, Ranitidine tablets are used under the strict supervision of a specialist. Throughout the entire course of treatment with this medicine, you must completely abstain from alcohol and other products that have a damaging effect on the gastrointestinal mucosa. When systematically using this drug as part of complex treatment, it is recommended to stop driving a car and other complex mechanisms for a while.

Discontinuation of this medication should be done gradually due to the high risk of developing rebound syndrome.

Possible adverse reactions

In most cases, side effects from taking Ranitidine appear after prolonged use of this medicine. The following disorders may occur as a result of using this drug::

If any of the above adverse reactions occur, the patient should urgently stop using this medication and be sure to seek advice from their doctor!

Ranitidine: instructions for use and reviews

Latin name: Ranitidin

ATX code: A02BA02

Active substance: ranitidine

Updating the description and photo: 14.08.2019

Ranitidine is an antiulcer drug that blocks H2-histamine receptors.

Release form and composition

Dosage form – film-coated tablets: round, biconvex, light orange in color (in blisters of 10 tablets, 2 blisters in a cardboard box).

Active ingredient: ranitidine (in the form of hydrochloride) – 150 or 300 mg per tablet.

Pharmacological properties

Pharmacodynamics

Pharmacokinetics

Indications for use

Exacerbation of gastric ulcer and duodenal ulcer (treatment and prevention);
Zollinger-Ellison syndrome;
Erosive esophagitis and reflux esophagitis;
Gastric and duodenal ulcers that developed as a result of taking non-steroidal anti-inflammatory drugs (NSAIDs);
Postoperative and stress ulcers of the upper gastrointestinal tract (treatment and prevention);
Prevention of Mendelssohn's syndrome (aspiration of gastric juice) during operations using general anesthesia;
Prevention of recurrent bleeding from the upper gastrointestinal tract.

Contraindications

Absolute:

Children under 12 years of age;
Pregnancy and lactation period;
Individual hypersensitivity to the components of Ranitidine.

Relative:

Liver cirrhosis with a history of portosystemic encephalopathy;
Liver and/or renal failure;
Acute porphyria, including a history of

Instructions for use of Ranitidine: method and dosage

Ranitidine tablets should be taken orally: swallowed whole with plenty of liquid. Eating does not affect the effectiveness of the drug.

Peptic ulcer of the stomach and duodenum: treatment of exacerbations - 150 mg in the morning and evening or 300 mg at night, in some cases it is possible to increase the dose to 300 mg 2 times a day, course of treatment - from 4 to 8 weeks; prevention of exacerbations - 150 mg 1 time per day at night, for smoking patients - 300 mg at night;
Peptic ulcer due to taking NSAIDs: treatment - 150 mg morning and evening or 300 mg at night for a course of 8-12 weeks; prevention – 150 mg morning and evening;
Postoperative and stress ulcers: 150 mg 2 times a day for 4-8 weeks;
Zollinger-Ellison syndrome: 150 mg 3 times a day, increase the dose if necessary;
Erosive reflux esophagitis: 150 mg morning and evening or 300 mg at night, in some cases the doctor may increase the dose to 150 mg 4 times a day, duration of therapy is 8-12 weeks. If long-term preventive therapy is necessary, 150 mg is prescribed 2 times a day;
Prevention of recurrent bleeding from the upper gastrointestinal tract: 150 mg 2 times a day;
Prevention of Mendelssohn's syndrome: 150 mg in the evening before surgery, then 150 mg 2 hours before anesthesia.

In case of renal failure (creatinine clearance less than 50 ml/minute), the daily dose should not exceed 150 mg.

Patients with concomitant liver dysfunction may also require a reduction in the daily dose.

Side effects

Allergic reactions: bronchospasm, skin rash, urticaria, anaphylactic shock, Quincke's edema, erythema multiforme;
From the cardiovascular system: atrioventricular block, bradycardia, decreased blood pressure, arrhythmia;
From the musculoskeletal system: myalgia, arthralgia;
From the nervous system: headache, drowsiness, dizziness, increased fatigue; rarely - tinnitus, involuntary movements, irritability, confusion, hallucinations (more often in older people and seriously ill patients);
From the hematopoietic organs: bone marrow hypo- and aplasia, agranulocytosis, immune hemolytic anemia, thrombocytopenia, leukopenia, pancytopenia;
From the digestive system: dry mouth, abdominal pain, diarrhea/constipation, nausea and/or vomiting; rarely - acute pancreatitis, cholestatic, hepatocellular or mixed hepatitis;
From the endocrine system: amenorrhea, gynecomastia, decreased libido, hyperprolactinemia, impotence;
From the senses: accommodation paresis, blurred visual perception;
Other: hypercreatininemia, alopecia.