Mildronate solution for injection. Mildronate: description, indications for use, general properties and effect

From this medical article you can familiarize yourself with the drug Mildronate. The instructions for use will explain in what cases the medicine can be taken, what it helps with, what are the indications for use, contraindications and side effects. The annotation presents the forms of release of the drug and its composition.

In the article, doctors and consumers can leave only real reviews about Mildronate, from which one can find out whether the medicine helped in the treatment of strokes, heart attacks and acceleration of metabolic processes in tissues in adult patients and children. The instructions list analogues of Mildronate, prices of the drug in pharmacies, as well as its use during pregnancy.

Mildronate is a synthetic drug that helps improve energy supply and tissue metabolism.

Release forms and composition

Mildronate is produced in the form of:

1. capsules 250 mg or 500 mg;
2. tablets Mildronate Gx 500 mg (slightly sour taste);
3. solution for intravenous injection (injections in ampoules). A solution for intramuscular administration does not exist in nature, only an intravenous method of administering the drug;
4. syrup.

One hard gelatin capsule of Mildronate contains 250 or 500 mg of Meldonium in the form of dihydrate as an active component and excipients.

One milliliter of Mildronate injection solution contains 100 mg of Meldonium and water for injection as an auxiliary component.

One Mildronate Gx tablet contains 500 mg of Meldonium in the form of phosphate and additional substances.

Pharmacological properties

The active ingredient Mildronate improves metabolism, promotes the removal of accumulated toxins from cells, has a tonic effect and protects cells from damage. As a result of using the drug, the ability to withstand stress and quickly recover from it increases.

Thanks to these properties, the drug is used to improve blood supply to the brain and treat various disorders of the cardiovascular system, as well as improve performance.

For heart failure, Mildronate, instructions for use confirms this fact, increases myocardial contractility, reduces the frequency of angina attacks, while increasing tolerance to physical activity.

For ischemic cerebrovascular accidents, the drug is used to improve blood circulation in the ischemic area, which promotes blood redistribution. The drug is also effective for disorders of the nervous system during withdrawal syndrome and fundus pathology.

What does Mildronate help with?

Indications for use include:

• physical overexertion (including among athletes);
• retinopathy of various etiologies (diabetic, hypertensive);
• thrombosis of the central retinal vein and its branches;
• reduced performance;
• complex treatment of acute and chronic cerebrovascular accidents (stroke and cerebrovascular insufficiency);
• withdrawal syndrome in chronic alcoholism (in combination with specific therapy for alcoholism);
• hemophthalmos, retinal hemorrhages of various etiologies;
• complex therapy of coronary artery disease (angina pectoris, myocardial infarction), chronic heart failure, dyshormonal cardiomyopathy.

Instructions for use

Mildronate capsules and tablets

Due to the possibility of developing an stimulating effect, the drug is recommended to be used in the first half of the day.

• For cardiovascular diseases, as part of complex therapy, the drug is prescribed orally at a dose of 0.5-1 g per day, frequency of use is 1-2. The course of treatment is 4-6 weeks.
• For cardialgia against the background of dyshormonal myocardial dystrophy, Mildronate is prescribed orally at a dose of 250 mg 2 times a day. The course of treatment is 12 days.
• For chronic alcoholism, the drug is prescribed orally at a dose of 500 mg 4 times a day. The course of treatment is 7-10 days.
• In case of cerebrovascular accident in the acute phase, the drug is prescribed intravenously (in the appropriate dosage form - 500 mg once a day for 10 days), then the drug is taken orally at 0.5-1 g per day. The general course of therapy is 4-6 weeks.
• For mental and physical stress, 250 mg is prescribed orally 4 times a day. The course of treatment is 10-14 days. If necessary, therapy is repeated after 2-3 weeks.
• For chronic cerebrovascular accidents, the drug is taken orally at 0.5-1 g per day. The general course of therapy is 4-6 weeks. Repeated courses are prescribed individually 2-3 times a year.
• Athletes are recommended to use 0.5-1 g 2 times a day before training. The duration of the course during the preparatory period is 14-21 days, during the competition period - 10-14 days.

Injections

• For mental and physical stress, 500 mg is prescribed intravenously once a day. The course of treatment is 10-14 days. If necessary, therapy is repeated after 2-3 weeks.
• For chronic alcoholism, the drug is prescribed intravenously at 500 mg 2 times a day. The course of treatment is 7-10 days.
• For vascular pathology and dystrophic diseases of the retina, Mildronate is administered parabulbarly in 0.5 ml of injection solution with a concentration of 500 mg/5 ml for 10 days.
• For cardiovascular diseases, as part of complex therapy, the drug is prescribed at a dose of 0.5-1 g per day intravenously (5-10 ml of injection solution with a concentration of 500 mg/5 ml), frequency of use 1-2 times a day. The course of treatment is 4-6 weeks.
• In case of cerebrovascular accident in the acute phase, the drug is prescribed intravenously at 500 mg once a day for 10 days, then the drug is taken orally (in the appropriate dosage form - 0.5-1 g per day). The general course of therapy is 4-6 weeks.

Side effects

Negative reactions occur quite often. Typically they are expressed as:

• increased arousal;
• dyspeptic symptoms, manifested by belching, attacks of nausea, vomiting, heartburn, a feeling of fullness in the stomach even after a small portion of food;
• decreased blood pressure;
• tachycardia;
• allergic reactions (redness, skin rashes, itching and swelling).

Contraindications

According to the instructions, Mildronate should not be taken in the following situations:

• increased intracranial pressure;
• individual intolerance to the drug Mildronate, from which these tablets and injections can cause allergies;
• intracranial tumors;
• pregnancy and breastfeeding;
• violation of venous outflow;
• children under 18 years of age.

With extreme caution, Mildronate injection solution and tablets are prescribed to persons suffering from kidney and liver diseases.

Use during pregnancy and lactation

The safety of Mildronate during pregnancy has not been proven. To avoid possible adverse effects on the fetus, the drug should not be prescribed during pregnancy. It is not known whether the drug is excreted in breast milk. If it is necessary to use Mildronate during lactation, breastfeeding should be discontinued.

special instructions

Due to the fact that the drug can provoke a stimulating effect, it is recommended to use it in the first half of the day. There are no data regarding the ability of Mildronate to change the reaction rate and influence transport control.

The drug is prescribed with caution to people with liver and/or kidney pathologies. Experience in treating patients with myocardial infarction and unstable angina shows that the active substance Mildronate is not a first-line drug for ACS.

Drug interactions

When used together, Mildronate enhances the effect of antianginal drugs, some antihypertensive drugs, and cardiac glycosides. The drug can be combined with antianginal agents, anticoagulants and antiplatelet agents, antiarrhythmic agents, diuretics, and bronchodilators.

According to the instructions, when used together with Mildronate, nitroglycerin, nifedipine, alpha-blockers, antihypertensive drugs and peripheral vasodilators may develop moderate tachycardia and arterial hypotension (care should be taken when using this combination).

Analogues of the drug Mildronate

Complete analogues for the active substance:

1. Vasomag;
2. Idrinol;
3. Cardionate;
4. Melfort;
5. Midolat;
6. Meldonium;
7. Meldonium-Eskom;
8. Meldonium dihydrate;
9. Medatern;
10. Trimethylhydrazinium propionate dihydrate.
11. 3-(2,2,2-Trimethylhydrazinium)propionate dihydrate.

Price

In pharmacies, the price for Mildronate capsules (Moscow) is 324 rubles for 40 tablets of 250 mg. For 10 injections of Mildronate 10% in 5 ml ampoules you need to pay 395 rubles.

• 1 Composition and release form
• 2 Mechanism of action
• 3 Indications for the use of Mildronate for blood pressure
• 4 Instructions for use and dosage
  • 4.1 During pregnancy and lactation
  • 4.2 Contraindications and side effects
  • 4.3 Overdose
• 5 Similar drugs
• 6 Special instructions

Is it allowed to take Mildronate for hypertension? Does the drug lower or increase blood pressure? First of all, you need to know that Mildronate is not an antihypertensive drug; its action is aimed at improving blood circulation in the brain. The medicine is prescribed to hypertensive patients with persistent pain in the heart and interruptions in the functioning of this organ. After taking the medication, you feel better and gain strength.

Composition and release form

The medical drug "Mildronat" is sold in the following forms:

• Solution for injection is colorless and odorless.
• Hard gelatin capsules. Inside the capsules there is a powder that has a mild odor and a sweetish taste.
• Tablets with a sour taste.

The components of the injection solution are water and propionate dihydrate. The tablet form of the medicine contains the following components:

• meldonium as an active ingredient;
• potato starch;
• food additive E572;
• Aerosil;
• gelatin;
• povidone;
• mannitol;
• food coloring E171.

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Mechanism of action

The drug affects high blood pressure as part of complex therapy.

Mildronate is a synthetic drug that has a beneficial effect on the metabolism and energy supply of cells. The drug exhibits a cardioprotective effect, and also improves the body's absorption of oxygen, increases the resistance of tissues and organs to hypoxia. The action of Mildronate is to reduce the permeability of vascular walls, as well as to relieve and prevent angina pectoris. As part of a complex treatment, the described medication is used to reduce high blood pressure, treat vegetative-vascular dystonia (VSD) and angina pectoris. In patients with impaired normal functioning of the heart and an increased pulse, Mildronate normalizes the heart rate.

The medication can increase the overall endurance of the body and tolerance to physical activity, as well as emotional shocks. As part of combination therapy, the drug can be taken not only for high blood pressure, but also for low blood pressure. If you have low blood pressure, increasing it with the help of Mildronate will help you quickly and completely get rid of the symptoms of hypotension, restore clarity in your head, vigor, and vitality. A positive effect of the drug on performance, endurance and recovery after hard work was noticed.

It is worth considering that fatigue, stress, overexertion, as well as pathologies of the cardiovascular system are reflected in the level of pressure. That is why Mildronate is considered extremely necessary for high blood pressure, because it reduces its levels through an effective effect on the body, curing not the consequence of the problem, but the root cause of the pathological condition.

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Indications for use of Mildronate for blood pressure

Mildronate is used individually or as part of complex therapy in the following cases:

• decreased performance;
• cardiac ischemia;
• high blood pressure;
• postoperative period;
• diffuse vascular damage to the brain;
• physical or mental overload;
• dysfunction of the heart muscle in chronic form;
• bronchial asthma;
• stroke;
• pain in the sternum on the left side;
• alcohol withdrawal syndrome;
• non-inflammatory damage to the retina of the eyeball.

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Instructions for use and dosage

The duration of treatment and dosage are determined by the doctor.

Mildronate tablets should be taken orally half an hour before or after a meal. It is recommended to take the medicine before lunch, and if several doses are required per day, then the last of them should not be later than 17:00. This is due to the fact that the drug causes psychomotor agitation. Patients whose blood pressure has increased are prescribed 750 mg per day, which can be taken at a time or divided into 2-3 doses. For angina pectoris, Mildronate 250 mg 3 times a day is prescribed as part of complex treatment. A heart attack is treated for 3-4 days, and then the dosage is reduced to 250 mg three times a day, 2 times a week for 1.5 months.

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During pregnancy and lactation

It is not recommended to use Mildronate for women pregnant or during breastfeeding, since there is no scientific research into the effect of meldonium on the fetus and the ability of this substance to penetrate into mother's milk. Nursing mothers should stop breastfeeding for the entire treatment period.

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Contraindications and side effects

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Overdose

By taking too large a dose of the drug, you can reduce your blood pressure to a critical level.

There have been no cases of overdose with the drug Mildronate. However, when using the medication in high doses, the following phenomena may occur:

• rapid decrease in pressure;
• headache;
• attacks of tachycardia;
• dizziness;
• general weakness.

If you observe the listed changes in the body that have arisen as a result of taking increased doses of the drug, you should immediately stop treatment and seek help from a doctor. The victim is entitled to symptomatic treatment. In case of severe overdose, monitoring of the functioning of the kidneys and liver will be required.

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Similar drugs

Structural analogues of the active substance and therapeutic effect of the pharmaceutical product Mildronate are:

• "Midolat";
• "Cardionate";
• "Vazomag";
• "Meldonium dihydrate";
• "Idrinol";
• "Meldonium";
• "Melfort";
• "Precard";
• "Angiosil";
• "Medatern";
• "Ethoxydal";
• "Antimten";
• "Koraksan";
• "Ubinon";
• "Orocamage";
• "Firazir".

It is important to consider that each drug that is synonymous with Mildronate has its own treatment regimen and its own application characteristics. Therefore, a replacement should be selected exclusively by a specialized doctor who, relying on the results of a diagnostic examination and the general condition of the patient, will establish the required dosage and determine the duration of the therapeutic course. Do not forget that self-medication can negatively affect the severity of the disease and provoke unwanted side symptoms.

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special instructions

When taking Mildronate, you should know some of its features. Patients with chronic kidney and liver diseases with long-term use of the medication need to monitor the indicators of the condition of these organs. For the treatment of high blood pressure, cardiac muscle dysfunction and angina pectoris, the described medication is used as part of a complex treatment to get rid of malaise, shortness of breath, and attacks of angina pectoris. Mildronate does not affect the ability to drive vehicles and operate various mechanisms that require increased concentration. Therefore, after taking a dose of medication, a person can engage in any type of activity.

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Mildronate: help with hypertension

Hypertension has become a widespread pathology today, with which patients have to constantly struggle. It is especially dangerous because it affects various systems of the body, leading to serious diseases. A variety of medications are used for hypertension. Mildronate stands out among the most effective remedies.

Mildronate is used in various fields, being a complex drug. It promotes:

• Improving metabolism;
• Providing maximum amounts of energy not only to tissues, but also to cells throughout the body.
• Elimination of functional disorders in the cardiovascular system.

Mildronate is able to have a comprehensive effect on the body at the cellular level. This makes it possible to cope with a number of chronic diseases or disorders in organ functions. This drug is included in the treatment of many diseases associated with the circulatory system, including hypertension, angina pectoris, coronary heart disease and so on.

Considering that the level of pressure is largely influenced by stress, fatigue, overexertion and problems in the cardiovascular system, this drug is able to effectively influence the body in a fairly short time, treating not the consequence, but the root cause of the pathological condition. That is why mildronate for hypertension is considered perhaps the first remedy “for all ills.”

Mildronate instructions

As mentioned earlier, this drug can have a complex effect on the body. The use of mildronate requires special attention so that the therapeutic effect is quick and at the same time long-lasting.

The product is available in the form of capsules, injections and syrup. The form of administration is determined by the doctor, based on the characteristics of the treatment.

The product contains meldonium, which is also called trimethylhydrazinium propionate dihydrate or mildronate. Any of the names may be indicated in the instructions for use. Reviews from patients often speak of distrust in the drug precisely because of the change in the names of the main active ingredient. But in all three cases we are talking about the same chemical substance.

Capsules and syrup also have excipients such as gelatin, titanium dioxide, starch, sorbitol, propylene glycol, and so on. That is why if you are allergic to any substance from the drug, you should tell your doctor about it. The solution for injection does not contain any excipients.

Mildronate dosage

Different forms of the drug have different dosages. Thus, capsules contain meldonium in dosages of 500 and 250 mg. 250 mg of mildronate is contained in 5 ml of syrup. That is, there are 50 mg in one milliliter. Solution for injection in 1 ml contains 100 mg of meldonium.

To indicate the required dosage, doctors prescribe Mildronate 500 or Mildronate 250 for capsules, where the number corresponds to the concentration of the active substance. Injections and syrup do not have concentration instructions and are calculated by the doctor in each specific case separately, taking into account the patient’s clinical picture.

Considering that mildronate is able to influence the body at the cellular level, improving metabolism and providing tissues with the necessary amount of energy, the drug has the following therapeutic effects:

Due to the peculiarities of the effects of mildronate in the retina, brain, and heart muscle, the drug is able to redistribute blood flow with a large volume of blood to the area that at that moment has an oxygen deficiency. Oxygen deficiency creates conditions for ischemia, and mildronate eliminates the cause of ischemia in tissues.

According to studies, mildronate, taken within four hours of the onset of a myocardial infarction, slows down the formation of areas of tissue necrosis. This results in shortening the time available for rehabilitation.

The drug has an equally impressive effect on coronary heart disease, cerebral circulatory disorders and alcohol withdrawal. The use of mildronate is considered most effective for:

Recipes with mildronate

Previously, meldonium was taken for the purpose of rapid recovery in sports. Today, this drug is officially considered a doping, which has limited its scope of demand. The drug is prescribed according to a regimen appropriate for the treatment of a specific disease. Tablets and syrup are taken orally before meals or 30 minutes after a meal.

Due to its obvious effect on the human body, mildronate is taken according to instructions in the first half of the day. The active substance causes psychomotor agitation, and, accordingly, can provoke the occurrence of insomnia.

There should be a gap of at least 4 hours from the last dose of the drug to rest. The course lasts a maximum of one and a half months, after which a break is taken. In adolescents, the course ranges from 2 to 6 weeks, depending on the diagnosis.

Reviews

The remedy has gained popularity not only among patients, but also among amateur athletes.

Oksana, 25 years old: “Mildronate was prescribed when I was a teenager and suffered from hypertension - that is, in adolescence. It helped a lot and now I’m quite healthy.”

Yaroslav, 37 years old: “I have no illnesses, and I take Meldonium as an aid in sports. Since I don’t dream of becoming a professional, I’m not afraid of doping. But performance in everyday life is excellent.”

Mildronate injections

Mildronate is a drug with metabolic activity, which improves the energy supply of cells and tissues. The positive effect of this drug on metabolism and the elimination of energy deficiency has made it possible to use Mildronate for many chronic diseases of the cardiovascular, respiratory, and nervous systems. It is also prescribed for the treatment of certain ophthalmological pathologies, increasing endurance, both physical and intellectual.

There are several forms of release of Mildronate, each of which can be prescribed based on the severity of symptoms, the patient's condition or his personal preferences. Doctors usually prescribe Mildronate injections in cases where it is necessary to quickly achieve a therapeutic effect or if the patient cannot take pills. Usually, the course of treatment can be continued in the future, switching from the injection to the oral form of the drug.

Description of the active substance

According to the instructions for use of Mildronate, the active ingredient in its composition is meldonium or trimethylhydrazinium propionate dihydrate. In structure, it is an analogue of gamma-butyrobetaine, which is present in all human cells. The mechanism of action of meldonium is to block the production of carnitine, as a result of which the synthesis of gamma-butyrobetaine increases. It promotes vasodilation and more efficient blood supply to tissues, especially those under hypoxic conditions.

The drug protects cells from the aggressive effects of catabolic products and toxins, accelerating the elimination of these agents from the body. With ischemia of tissues and organs (for example, myocardium, brain, retina), meldonium changes the blood flow ratio in favor of areas with hypoxia. Thus, its anti-ischemic and antihypoxic effect is manifested.

In conditions of acute lack of myocardial blood circulation, Mildronate helps slow down the formation of necrotic damage and shortens the rehabilitation period. For angina pectoris, the drug reduces the number of attacks of anginal pain and increases cardiac output. Thanks to it, the stimulation of neurons increases, the motor sphere and physical endurance are activated. It also has an anti-stress effect.

Meldonium improves the course of the rehabilitation period in patients who have suffered vascular, inflammatory diseases of the brain or had injuries to the central nervous system. It reduces movement disorders (paresis), improves coordination, and reduces the severity of vegetative manifestations. The use of the drug helps improve the condition of patients with alcohol dependence and reduces the manifestations of withdrawal syndrome.

Pharmacokinetics

The maximum plasma concentration of Mildronate for injection is achieved almost immediately after its parenteral administration. It is quickly distributed in tissues and binds to blood plasma proteins. The bioavailability of the drug is 100%.

Attention! The drug partially penetrates the hematoplacental barrier, and has also been found to pass into breast milk.

The drug and its metabolites are excreted primarily by the kidneys. The half-life is 3-6 hours.

Indications

What is Mildronate used for, and when can it be useful? Indications for the use of the drug are the following pathological conditions:

• cardiovascular pathology: chronic ischemic heart disease, angina pectoris, myocardial infarction, chronic heart failure;
• dishormonal cardiomyopathy;
• vegetative-vascular dystonia;
• chronic circulatory disorders in the brain;
• cerebral stroke;
• pathology of peripheral arterial vessels;
• postoperative recovery period;
• bronchial asthma and chronic obstructive pulmonary disease as a component of complex treatment;
• eye diseases of various origins: hemorrhage in the retina and vitreous body of the eye, retinopathy (hypertensive and diabetic), thrombosis of the central retinal vein, impaired blood supply to the retina.
• chronic alcoholism and withdrawal syndrome in alcohol addicts in combination with other types of treatment;
• high physical fatigue and overstrain;
• low productivity of physical and intellectual labor.

Attention! For diseases of the organ of vision, the use of Mildronate injections only parabulbarly is indicated.

Among the indications for the use of Mildronate, sports training has also found its niche in order to increase endurance, for quick recovery after hard and long-term sports.

How to take the drug?

Mildronate solution has a meldonium concentration of 10%. It is produced in ampoules of 5 ml. Accordingly, 1 ml of solution contains 100 mg of meldonium, and one ampoule contains 500 mg. The box contains 10 ampoules. The drug is prescribed 1 or 2 times a day. The drug solution can be administered in several ways:

• intramuscularly;
• intravenously;
• parabulbar (near the eyeball).

Mildronate is usually administered intravenously in a jet manner, this way the desired effect can be achieved faster. If there is no urgent need for immediate action of the drug, then it can be injected into a vein using a dropper.

Mildronate solution is available in a sufficient concentration of the active substance and does not require additional dilution. This applies to all methods of injection delivery of the drug. However, doctors may prescribe its administration, for example, with saline solution. If Mildronate is nevertheless diluted, then the absolute amount of the active substance will not change, only its concentration will decrease, which may affect the speed of onset of the drug’s action.

In cases where rapid action is not required, Mildronate can be diluted. For this purpose only, it is better to use a 0.9% sodium chloride solution (saline). Mixing with other solvents may affect the properties of the drug, which is extremely undesirable.

Mildronate activates nervous activity, so it should be taken at least 4-6 hours before bedtime. Otherwise, sleep disturbance in the form of insomnia may occur. The daily dose can be taken in one injection or divided into two doses.

Dosage for various pathologies

The dose of the drug depends on the specific disease and is selected by the doctor individually:

• Unstable angina and myocardial infarction. In such cases, intravenous administration of the drug is indicated, since these conditions are acute and require immediate intervention. 5-10 ml of Mildronate are administered intravenously. If injections are poorly tolerated, the entire dose is administered once; in other cases, dividing it into two injections is indicated. The duration of parenteral administration of drugs ranges from 1 to 10 days. In the future, you can switch to oral forms of Mildronate and take it in a general course lasting up to 4-6 weeks.
• Chronic circulatory failure. Use 5-10 ml IV once a day or 5 ml twice a day IM. The course lasts up to 2 weeks with a transition to syrup or tablets.
• Ophthalmological pathology. In this case, Mildronate is used parabulbarly at 0.5 ml per day (50 mg meldonium) for 10 days.
• Brain stroke in the acute phase. To achieve a quick effect from the use of the drug, it is administered intravenously at a dose of 5 ml per day for 10 days. You can also inject it intramuscularly at a dose of 500 mg once a day for 2-3 weeks.
• Chronic cerebrovascular insufficiency. For this pathology, the drug is administered either intramuscularly or in tablet form. Inject 5 ml of solution intramuscularly 1 time for 14 days. Reception is extended if necessary up to 4 weeks.
• Dyshormonal cardiomyopathy. Apply 5-10 ml intravenously in one injection per day or 5 ml intramuscularly 2 times a day. The course is 14 days, and if oral administration is continued, it is recommended to take Mildronate for another 2 weeks.
• Chronic alcoholism. Patients receive Mildronate intravenously, 5 ml 2 times a day to relieve neurological symptoms. Continue therapy for up to one week.
• Increased fatigue during periods of high physical and intellectual stress. There is no urgent need for parenteral administration of Mildronate for such indications, but it all depends on which method is more acceptable to the patient and how quickly the effect is expected. The drug is taken intramuscularly, 1 ampoule 1 or 2 times a day. It is also possible to take Mildronate intravenously in a similar dosage regimen. The course of treatment is up to 2 weeks. If there is a need, it can be repeated after another 2-3 weeks.

Interaction

Mildronate, interacting with other drugs, can cause both desirable and dangerous reactions in the body. Many patients are interested in whether it is possible to combine meldonium with other drugs. Only a doctor can give a definite answer to this question.

Meldonium increases efficiency:

• antiplatelet agents;
• anticoagulants;
• bronchodilators;
• antiarrhythmics;
• antianginal drugs;
• diuretics.

The drug potentiates the effect of beta blockers and cardiac glycosides. Particular caution should be taken when taking Mildronate with the following drugs:

• alpha blockers;
• nitrates;
• calcium channel antagonists;
• peripheral vasodilators.

Taking these drugs together can lead to a sharp decrease in blood pressure and tachycardia.

Contraindications

According to the instructions for use of the drug, it is not prescribed in the following cases:

• pregnancy;
• lactation period;
• children under 12 years of age;
• increased intracranial pressure;
• allergy or the presence of individual hypersensitivity to meldonium.

Side effects and drug overdose

Typically, patients experience a high degree of tolerability of the drug, but sometimes there are cases of adverse reactions to Mildronate:

• skin allergic manifestations in the form of rash, urticaria, rarely - angioedema;
• dyspepsia;
• fluctuations in blood pressure;
• increased heart rate;
• insomnia and psychomotor agitation;
• weakness;
• change in blood count (increased level of eosinophils).

special instructions

In patients who have serious kidney and liver diseases with insufficiency of the functions of these organs, biochemical blood parameters should be monitored. If long-term use of meldonium is necessary, consultation with the attending physician is required to adjust the dose of the drug.

A person taking Mildronate may be allowed to drive vehicles and operate machinery, since the drug does not cause a slowdown in reactions. Elderly patients should reduce the therapeutically effective daily dose.

Application in sports

Due to Mildronate's ability to increase the absorption of oxygen by tissues, it can be recommended for increasing tolerance to physical activity. It improves nutrition of the myocardium and peripheral muscles. This helps reduce fatigue and speed up recovery after training.

Storage conditions

After opening the ampoule, the solution cannot be stored under any circumstances. A refrigerator is also not suitable for this purpose. After 20 minutes or more have passed after the seal has been broken, the ampoule should be discarded.

Medicines help maintain and maintain health. An active substance that helps solve a specific problem can be produced in various dosage forms by a huge number of pharmaceutical companies, and therefore similar and even identical products often have many different names. For example, pharmacists in pharmacies very often hear the question from customers: “Cardionate” or “Mildronate” - which is better?” We will try to answer it in this article.

Medicine for life?

One of the medicinal substances actively used to maintain health is meldonium. It is part of a group of metabolic elements that actively work in energy metabolism processes at the cellular level. The pharmaceutical industry of different countries has developed and produced a huge number of drugs using this substance as the main active component. Frequently asked questions about two of them: Cardionate or Mildronate - which is better? Feedback from doctors and patients, as well as a comparative analysis, will allow you to answer it as accurately as possible.

History of discovery

The substance meldonium has a very interesting path into the pharmaceutical industry and is in demand on the drug market. It was originally obtained synthetically as a result of searching for the problem of rocket fuel disposal. This happened in the 1970s at the Institute of Organic Synthesis at the Academy of Sciences. First, meldonium began to be used in plant growing to stimulate growth, then its ability to act as a cardioprotector in animals was discovered. It was then that the decision was made to conduct the necessary research and testing so that meldonium would be among the medicinal substances. Today it is widely used both in clinical medicine and in sports. Meldonium is included in the List of vital and essential drugs, which is approved by the Russian Government. This substance is included in many medications, for example, Mildronate and Cardionate. Comparing these drugs will ensure that they are similar.

In what form are medications containing meldonium available?

For many patients who are prescribed a drug with meldonium, the question arises: “Mildronate”, “Cardionate” - is there a difference between them? Let's consider these drugs from the point of view of release form. The drug "Mildronat" has three dosage forms:

• gelatin capsules containing 250 or 500 mg of meldonium;
• tablets 500 mg of active substance;
• injection solution, 1 ml of which contains 100 mg of the active ingredient.

Two forms of release are registered for the drug "Cardionat":

• gelatin capsules containing either 250 mg or 500 mg of meldonium;
• solution for injection in 5 ml ampoules containing 500 mg of active substance.

Answer the question by considering the release forms of the drugs, “Cardionat” or “Mildronat” - which is better? - it is impossible, since they are produced in the same form with the same amount of active ingredient.

About Cardionate

The drug "Cardionat" is produced in Russia by Makiz-Pharma LLC, located in Moscow. The company is engaged in the development and production of finished dosage forms. The product line includes 43 items, including the drug with meldonium "Cardionate". It is available in two medicinal forms - in capsules and as an injection solution, and in both forms it is the only active component. The remaining substances present in drugs play a formative role. For capsules it is:

• colloidal silicon dioxide;
• calcium stearate;
• potato starch.

In addition to meldonium, the ampoules contain water for injection in the amount necessary to concentrate the solution.

About "Mildronat"

The medicinal substance with meldonium under the brand name "Mildronat" is produced by the pharmaceutical company JSC Grindeks (AS Grindeks), which unites five enterprises from Latvia, Slovakia, Russia, and Estonia. It was in Latvia that the substance meldonium was patented in 1992. The Grindeks association is engaged in the development, production and sale of both dosage forms and individual substances used in pharmaceuticals, in the production of cosmetics, and sports nutrition. One of these substances is meldonium. The drug "Mildronat", which is produced in three dosage forms, contains the only working substance - meldonium. All other components included in the structure of drugs are formative substances:

• the capsule shell consists of titanium dioxide (white coloring matter), gelatin, potato starch, colloidal silicon dioxide;
• tablet form consists of silicon dioxide, potato starch, mannitol, povidone, magnesium stearate, microcrystalline cellulose;
• the injection solution is based on special water, taken in the amount necessary to obtain the percentage of the medicinal substance in 1 ml of solution.

Considering the dosage forms and composition of the active component and excipients, we can conclude that Cardionat and Mildronate are the same medicine from different manufacturers.

How does the active substance work?

Meldonium is responsible and actively involved in energy metabolic processes occurring in the cells of living organisms. Balance is the basis of life, and balance is at the cellular level - In some conditions, the active work of carnitine, which serves as a conductor of long-chain fats into the mitochondria of cells for their breakdown and energy production, must be reduced, since fats do not have time to be broken down and accumulate in the form of non-oxidized active fatty acids forms

The process of proper healthy oxidation takes place with the participation of oxygen, but during certain diseases and pathological conditions there is a lack of oxygen and a slowdown in the oxidation of fats to biologically digestible structures. Meldonium blocks carnitine, preventing fats from entering the mitochondria without sufficient oxygen.

This substance has the following functional abilities based on improving metabolic processes by activating the supply of oxygen to cells:

• antianginal;
• antihypoxic;
• angioprotective;
• cardioprotective.

The bioavailability of meldonium in various pharmaceutical forms is about 80%. It is quickly absorbed from the gastrointestinal tract, and reaches peak concentration in the patient’s blood within 1.5-2 hours. This substance is then metabolized in the liver to non-toxic components, which are excreted in the urine.

In what cases is the use of drugs with meldonium indicated?

Since the active substance meldonium is included in the preparations Cardionat or Mildronate, their indications for use will be the same. They are used in the treatment of such diseases and conditions:

• alcohol withdrawal;
• peripheral arterial disease;
• bronchial asthma;
• encephalopathy;
• stroke;
• cardiac ischemia;
• cardialgia with myocardiopathy;
• retinal hemorrhages;
  
• occlusion of the central retinal vein or its branches;
  
• acute disturbance of the blood supply to the retina;
  
• postoperative period;
• retinopathy of various etiologies;
• chronic heart failure;
• reduced performance;
• thrombosis of the central and peripheral retinal veins;
  
• physical overload (including sports);
• chronic obstructive pulmonary disease;
• cerebrovascular insufficiency.

When prescribing this drug, all basic methods of treating diseases are preserved. The drug can be used both as the main and as an auxiliary component.

Are there any contraindications?

If necessary, the doctor prescribes the drugs Cardionat or Mildronate. They contain the same active substance - meldonium. Contraindications to the use of these drugs will be the same:

• individual high sensitivity to meldonium or to the auxiliary components of the drug;
• intracranial hypertension resulting from intracranial tumors or impaired venous outflow.

The use of drugs with meldonium is not recommended for children under 18 years of age, as well as for pregnant and breastfeeding women. This ban is due to the lack of knowledge of the effect of the active substance on the body of a child or fetus. Extreme caution and constant monitoring of health requires taking meldonium preparations for pathologies of the liver and/or kidneys.

What about the side effects?

When deciding whether Cardionate or Mildronate is better, for many patients one of the factors is the potential for side effects. But since both drugs are medicinal products containing meldonium and do not contain other active components, their manifestation will be the same. Side effects when using these medications may include:

• rashes on the skin;
• hyperemia;
• hypotension;
• heartburn;
• edema;
• belching;
• increased arousal;
• tachycardia;
• nausea.

Side effects of drugs containing meldonium are extremely rare.

Meldonium and sporting achievements

Until recently, one could hear a debate about “Cardionate” or “Mildronate” - which is better for sports? Meldonium increases the endurance of athletes, allowing them to recover faster after active training and performances in competitions. The World Anti-Doping Agency (WADA) has included this substance in the list of prohibited substances for use by athletes. The Meldonium scandal with Russian athletes has caused significant damage to the prestige of our sport. Today, the question of whether Cardionate or Mildronate is better is debated only in clinical medicine and behind the scenes of sports.

Features of the use of drugs with meldonium

Only a doctor can prescribe the use of drugs with meldonium according to the available indications. He will choose the form of the medicine and the mode of application. Patients should take into account some features of the use of both Cardionate and Mildronate:

• It is best to take the medicine in the first half of the day, so that as a result of the development of increased arousal, as a side effect, it does not spoil the night’s sleep;
• when administering the drug intramuscularly, quite severe pain may be felt at the injection site, so administering the drug intravenously is preferable;
• in the treatment of retinopathy, drugs with meldonium are administered only parabulbarly (in the area of ​​the lower eyelid under the skin or to a depth of 1 centimeter), this is a very painful injection;
• It is not recommended to take alcohol during treatment with drugs containing meldonium due to a possible decrease in the quality of treatment and the development of adverse reactions in the body.

The doctor must take into account the interaction of drugs, as well as the patient’s condition and the course of the disease. Meldonium potentiates the activity of drugs with coronary action, antihypertensive drugs, as well as drugs that promote dilation of peripheral blood vessels. The combined use of such drugs may cause tachycardia and low blood pressure.

Mildronate is a synthetic drug that improves energy supply and tissue metabolism.

pharmachologic effect

The active ingredient Mildronate improves metabolism, promotes the removal of accumulated toxins from cells, has a tonic effect and protects cells from damage.

As a result of the use of Mildronate, the ability to withstand stress and quickly recover from it increases. Thanks to these properties, the drug is used to improve blood supply to the brain and treat various disorders of the cardiovascular system, as well as improve performance.

In case of heart failure, Mildronate, according to the instructions, increases myocardial contractility, reduces the frequency of angina attacks, while increasing tolerance to physical activity.

For ischemic cerebrovascular accidents, Mildronate is used to improve blood circulation in the ischemic area, which promotes blood redistribution.

Also, according to reviews, Mildronate is effective for disorders of the nervous system with withdrawal syndrome and pathology of the fundus.

Release form

Mildronate is available in the form:

• A colorless transparent solution, 1 ml of the drug contains 100 mg of the active substance - meldonium. In ampoules of 5 ml;
• White gelatin capsules containing the active substance in the form of crystalline powder with a slight odor. 250 or 500 mg of active ingredient per capsule, 10 pieces per blister.

Indications for use of Mildronate

Mildronate is indicated for use in complex therapy:

• For coronary heart disease, including myocardial infarction and angina, as well as for heart failure and dyshormonal cardiomyopathy;
• For strokes and cerebrovascular insufficiency.

Mildronate is also used for:

• Reduced performance;
• Retinopathy of various etiologies, including diabetic and hypertensive;
• Hemophthalmia and retinal hemorrhages of various etiologies;
• Physical overstrain;
• Thrombosis of the central retinal vein and its branches;
• Withdrawal syndrome in chronic alcoholism, in combination with specific therapy.

Contraindications

According to the instructions, Mildronate is contraindicated for use in children under 18 years of age, with hypersensitivity to the drug, as well as with increased intracranial pressure, including intracranial tumors and disorders of venous outflow.

Reliable studies on the use of Mildronate during pregnancy and lactation have not been conducted, as a result of which the drug is not recommended for use during these periods.

Mildronate is used with caution, especially for a long time, in case of liver or kidney diseases.

Instructions for use of Mildronate

The dose and route of administration of Mildronate depend on the disease:

For disorders caused by chronic alcoholism, usually take 1 tablet of Mildronate (500 mg) 4 times a day for 10 days.

Mildronate is indicated for use in the first half of the day due to the possibility of developing an stimulating effect.

Side effects

According to reviews, Mildronate is a low-toxic drug and does not cause side effects hazardous to health. Extremely rarely:

• Changes in blood pressure;
• Tachycardia;
• Dyspeptic symptoms;
• Psychomotor agitation.

Also, according to reviews, Mildronate can cause allergic reactions in the form of swelling, rash, redness or itching of the skin.

Caution should be exercised when used simultaneously with certain antianginal and antihypertensive drugs, as well as cardiac glycosides, since Mildronate enhances their effect.

When used simultaneously with Mildronate, antihypertensive drugs, nifedipine, nitroglycerin, peripheral vasodilators and alpha-blockers may develop moderate tachycardia and arterial hypotension.

Mildronate can be taken with anticoagulants and antiplatelet agents, as well as diuretics and antiarrhythmics.

Storage conditions

Mildronate is available with a prescription. The shelf life of injection solution and tablets is 4 years.

Sincerely,

You can use Mildronate intramuscularly or take it in tablets.

Action of the drug

Mildronate is an artificial analogue of gamma-butyrobetaine. This substance is found in every tissue cell of the human body. The mechanism of action of this drug is based on its beneficial effect on energy metabolism processes, as well as the tonic effect it has on the central nervous system. Under conditions of high stress on the body, the medication ensures balance in the processes of delivery and use of oxygen in cells. It optimizes metabolic processes in such a way that the level of oxygen demand is reduced to produce energy. As a rule, prolonged heavy loads lead to increased fatigue. When using the drug Mildronate intramuscularly or in tablets, the body tolerates stress more easily, uses oxygen sparingly and quickly restores energy reserves to withstand new challenges. This product performs the function of gamma-butyrobetaine, which is able to increase the speed of transmission of nerve impulses. As a result, all reactions are accelerated, and the quality of general metabolism improves. Therefore, when using the drug "Mildronat" intramuscularly or in tablets, the body's capabilities increase.

Dosages

For significant mental and physical stress (including in sports), the following doses of the drug are recommended: for adults, the optimal regimen is 1 tablet of 250 mg four times a day. The course is two weeks. If necessary, therapy can be repeated after three weeks. The drug "Mildronat" is injected intramuscularly at a dose of 500 mg once a day. This is the optimal regimen and dosage. Where to give injections? Mildronate can be injected into the gluteal muscles. For athletes, the dosages are slightly different. It is recommended to take the medication in tablets before training twice a day. When preparing for competitions, the duration of the course is 2-3 weeks. Their period is no more than 14 days. Caution should be exercised during co-administration with nifedipine, antihypertensive drugs, nitroglycerin, alpha-blockers and peripheral vasodilators.

The drug "Mildronat": analogues

The drug "Carnitine" (L-carnitine) is similar in its action to the drug "Mildronat". Both of them, during ischemia, reduce the level of fatty acids in the mitochondria that remain under-oxidized. Both drugs are stimulants of alternative energy synthesis. In fact, the drug Mildronate does not allow harmful fatty acids into the mitochondria, and the drug Carnitine removes them from there by increasing the concentration of the substance of the same name. The mechanisms of action of these drugs are somewhat different, but their tasks are similar. The drug "Carnitine" stimulates metabolic processes, affects different stages of energy metabolism, takes part in lipid metabolism, restores alkaline blood reserves, and helps reduce the formation of keto acids.

This product does not affect the blood coagulation system in any way, increases tissue protection from toxic compounds, has an antihypoxic effect, inhibits anaerobic glycolysis, stimulates aerobic processes, and accelerates wound healing. The drug can be used intravenously and orally. It is not advisable to use this remedy together with glucocorticoid medications. They contribute to the accumulation of the active substance in the body. The drug "Carnitine" enhances the effect of anabolic agents.

Mildronate - solution for injection

Mildronate is a medicine of synthetic origin. Instructions for use indicate that regular and correct use of the product helps improve energy supply and metabolism within tissues. The dominant component is meldonium. Most often, injections are prescribed to patients diagnosed with coronary heart disease, dyshormonal cardiomyopathy, heart failure and stroke.

Compound

The drug in the form of an injection solution is available in the form of a clear, colorless liquid. Each cardboard branded box contains 10 ampoules with a volume of 5 milliliters, located in a honeycomb blister.

The main active component is propionate dihydrate. In each ampoule it is 100 milligrams. Among the additional ingredients there is only sterile injection water.

In addition to administering the drug intramuscularly, Mildronate is also produced in tablet and capsule form. The drug in the form of capsules is produced in concentrations of 250 and 500 milligrams of the active ingredient. The capsule body is made of special gelatin, which quickly dissolves under the influence of gastric juice.

Additional substances in the capsule form of the drug are: calcium stearate; the capsule body is made of gelatin and titanium dioxide. Capsules are packaged in blisters of 10 units, also sealed in a branded box (each contains 4 blisters), which contains instructions for use.

Tablets are produced in a single dosage, which is 500 milligrams of the active ingredient. Among the excipients present here are: mannitol, povidone, potato starch, silicon dioxide, cellulose microcrystals, magnesium stearate.

Indications

Manufacturers of the drug identify the following series of indications for which Mildronate is prescribed intramuscularly or orally:

1. Heart failure;
2. Dyshormonal cardiomyopathy;
3. Cardiac ischemia;
4. Angina;
5. Myocardial infarction;
6. Stroke;
7. Cerebrovascular insufficiency.

It is no less effective to take the medicine in case of frequent and severe physical stress, if a decrease in performance is noticed, there is thrombosis of the retinal vein or hemorrhage of various origins, with hemophthalmitis, withdrawal syndrome, retinopathy of various forms, including diabetic and hypertensive.

Contraindications

Instructions for the use of Mildronate injections describe the following series of contraindications, in the presence of which the use of the drug in therapy is unacceptable:

1. Increased individual sensitivity to the main component of the drug or additional components;
2. The likelihood of allergic or adverse reactions occurring during treatment;
3. High intracranial pressure;
4. Dysfunction of venous blood outflow;
5. Tumors localized inside the skull;
6. The patient's age is less than 18 years;
7. Any trimester of pregnancy;
8. Breastfeeding period.

Mildronate should be especially carefully prescribed and taken by people who have dysfunction or pathologies of the kidneys and liver.

Mode of application

Doctors administer the medicinal solution for injection in three different ways: intramuscularly, intravenously or percutaneously into the lower eyelid area. So, intravenous administration means the injection of a substance into a vein, where it is immediately mixed with blood serum.

If the drug is administered intramuscularly, it initially enters the muscle fibers, and from there it is gradually distributed throughout the tissues and penetrates the blood. What frightens patients most is the injection into the skin of the eye. But do not worry if the injection is performed by an experienced specialist. This method of injection is necessary exclusively to combat eye diseases.

There are no different injection solutions of the drug Mildronate for different types of injections. All use the same solution, which is presented at a concentration of 100 milligrams per 1 milliliter of liquid. It is strictly forbidden to open the ampoule in advance. This procedure must be performed before the injection. The solution is not intended for storage in the open air or at low temperatures; if the ampoule is opened, Mildronate is placed in a syringe.

The maximum time after opening the ampoule is only 20 minutes. When the allotted time period ends, it is necessary to get rid of the medicine, and the injection is performed with the medicine from the newly opened ampoule.

Also, before drawing the solution into the syringe, it must be carefully inspected. The medicine should not change color, it should be checked for the presence of flakes and other impurities. If atypical components are detected, Mildronate should not be used.

The instructions indicate that injection procedures should be carried out in the morning or before lunch, due to the stimulating effect of Mildronate. In situations where the patient is prescribed more than one injection per day, the last injection should be done no later than five hours before going to bed at night. If there are no concerns and the patient is confident that he can give himself an injection on his own, then the procedure can be carried out at home. It is important to follow all antiseptic rules, which will prevent infection from entering the injection area.

When prescribing intravenous and parabulbar administration, the procedure should be performed only in a clinic setting. In exceptional cases, a medical professional can be called to your home to perform intravenous injections.

Dosages

Standard doses and the interval between intravenous and intramuscular injections of the drug are always the same. Depending on how quickly the therapeutic effect should occur, the injection technique is selected.

In situations where the patient is in a critical condition, that is, to quickly relieve unpleasant symptoms and prevent the progression of the pathological condition, intravenous administration is chosen, which is due to the rapid penetration of the active component into the blood; accordingly, the therapeutic effect will occur much faster.

If it is necessary to achieve a prolonged action, so that the substance is distributed and enters the blood slowly, preference is given to intramuscular injections. This technique is best suited for the treatment of pathologies that occur in a chronic form.

From this we can briefly conclude that intravenous administration is justified in the acute condition of the patient, and intramuscular administration in chronic pathologies. Administration by the parabulbar method is indicated exclusively for the treatment of ophthalmological diseases.

Considering the standard dose, which is usually indicated in the instructions for use of the drug, in relation to Mildronate the volume corresponding to 500 milliliters per day is indicated, which is equal to five ampoules. This applies to intravenous or intramuscular injections.

To perform an injection in the eye area, no more than 50 milligrams of the drug is administered per day, which corresponds to 0.5 milliliters. It is also worth noting that the dosage can be changed up or down by your doctor. This may be required in acute, or, conversely, not very pronounced pathological conditions, which means it depends directly on the severity and degree of development, as well as the type of disease.

Myocardial infarction or unstable angina. Mildronate is administered intravenously. The recommended daily dosage is from 500 to 1000 milliliters. The specified volume can enter the patient’s body during one or two procedures.

Accordingly, if the patient tolerates the injections quite hard, then it is better for him to administer the entire dose in one procedure. In situations where a person has a normal attitude to intravenous injections, it is better to administer the medicine twice a day, dividing the dose into equal parts, that is, per milligram.

It is very important that the entire prescribed dose of the drug enters the body within one day. Subsequent treatment can be carried out by taking oral forms of Mildronate.

But at the same time, if the patient, for individual or other reasons, for example, has dysfunction, gastrointestinal pathology, cannot take the tablet form of the drug, as well as with low therapeutic effectiveness after taking it, then further treatment is carried out by performing intramuscular injections .

With this treatment regimen, patients are prescribed procedures for one to one and a half months. The dosage ranges from 500 to 1000 milligrams of Mildronate, and the interval between injections is three days. The indicated volume can be administered twice, dividing the dose into 2 injections or at one time.

Chronic heart failure. Initially, intravenous administration of the drug is performed in a dosage of 500 to 1000 milligrams per day, which is equal to 5 or 10 milliliters of solution, respectively. Daily twice-daily intramuscular administration of Mildronate is allowed. In this case, the dose per injection should be 500 milligrams of the drug. The duration of therapy is from 10 days to two weeks.

After the main course of drug treatment by intravenous or intramuscular administration has been completed, the patient is taken to take the drug Mildronate orally. The duration of such therapy is about a month, but not less than 21 days.

If the patient was admitted to a medical institution during a period of acute circulatory disorders in the brain, then he is indicated for daily intravenous administration of 500 milligrams of the drug for 10 days. Upon completion of the course of intensive therapy, the patient may be offered to switch to treatment with oral forms of Mildronate, or they will continue injection procedures, but intramuscularly.

When treating by injecting medication into muscle fibers, it is recommended to carry out the procedure once a day, at which time the patient will be injected with 500 milligrams of the drug. The duration of treatment is two to three weeks. If a patient is diagnosed with a chronic type of cerebral circulatory disorder, he may be offered ongoing maintenance therapy by oral administration or intramuscular administration of Mildronate.

It is important to note that in this condition, the patient can independently choose the preferred method of obtaining the medicine. Also, do not forget about how the body reacts to oral administration of the drug, whether there are pathologies or dysfunctions of the gastrointestinal tract.

Perhaps in some situations, for example, when the patient is unable to swallow a tablet or it is not absorbed in the stomach, it would be preferable to opt for intramuscular treatment. If it is possible to take the medicine in tablets, then it is better to give preference to this type of therapy.

Chronic cerebrovascular accident. If a patient has such a condition, he is recommended to administer Mildronate daily by intramuscular injection at a dosage of 500 milligrams, which corresponds to 5 milliliters of solution. The duration of such therapy ranges from 14 to 21 days. The treatment course can be repeated twice or thrice a year, if indicated.

Dyshormonal myocardial dystrophy. A similar pathological condition, accompanied by obvious pain in the heart area, can be treated with Mildronate by intravenous administration of the drug. A dosage of 500 to 1000 milligrams of the product is indicated, which corresponds to 5 or 10 milliliters of solution, once within 24 hours.

If treatment is performed by intramuscular injections, then 500 milligrams (65 milliliters of solution) should be administered twice a day for days. If the course of injection therapy has already been completed, and the unpleasant, painful sensations in the heart area have not left the patient, he will be advised to take Mildronate tablets for 12 days.

Mental and physical stress, postoperative rehabilitation. The drug can be taken orally in tablet form, or preference can be given to intravenous or intramuscular administration.

The patient must decide how to take the drug; if he is unable to do this on his own, he should seek medical help. Taking the medicine in tablet form is not possible in situations where the medicine is not absorbed or rejected by the gastrointestinal tract, or there is a low therapeutic effect from it.

When Mildronate is administered intravenously or intramuscularly, a dosage corresponding to 500 milligrams of the drug per day, administered at a time, or 250 milligrams twice a day is indicated. The duration of therapy is from 10 to 14 days.

If there are medical indications, then a second course of treatment with Mildronate should be carried out, but not earlier than one day after the last injection.

Chronic alcoholism. The drug is administered intravenously only if there is obvious damage to the patient’s nervous system. For this condition, a dose of 500 milligrams (5 milliliters of solution) twice daily for one week (maximum 10 days) is recommended.

Fundus vascular diseases and retinal dystrophy. The drug is administered parabulbarly in a volume corresponding to 500 milligrams (5 milliliters of solution) once a day. The duration of treatment is one and a half weeks.

If it is necessary to stop the inflammatory process localized in the eyes, a combination of Mildronate with intravenous or intraocular administration of hormonal corticosteroid drugs, for example, Prednisolone, Dexamethasone or Betamethasone, is recommended.

If retinal dystrophy is diagnosed, then it is best to combine the drug with drugs whose action is aimed at improving internal blood circulation.

Pregnancy

There is no sufficient medical data regarding the use of Mildronate in any trimester of pregnancy. In order to avoid any possibility of negative effects on the fetus, the possibility of the formation of malformations and other complications, doctors do not prescribe Mildronate during pregnancy.

Also, doctors and scientists to this day have not determined whether the drug is excreted in breast milk. Therefore, if a child is breastfed naturally, and also needs to undergo treatment with Mildronate, the baby should be transferred to feeding with special artificial formulas.

special instructions

It is impossible to unequivocally answer the question of how long it is safe to undergo treatment with Mildronate. Everything here is purely individual and directly depends on the diagnosed pathology, the patient’s condition and his age. As the instructions for use indicate, the average duration of therapy does not exceed 60 days.

If a drug is prescribed for the prevention and prevention of relapse of any pathology, the duration of its use is about 45 days. Some time after treatment, as well as having previously undergone consultation with a leading specialist, the doctor will indicate the time when a second course of treatment should be carried out.

Every patient who has dysfunction or pathology of the liver or kidneys should be under special supervision from a medical specialist. In situations where the patient requires long-term treatment, more than 30 days, it is important to regularly come for medical examinations.

Depending on the status of the pharmacy and the region of purchase, the cost of the drug Mildronate will differ. So, on average, the price for 40 tablets in a dosage of 250 milligrams is about 300 rubles. For 10 ampoules of a solution for injection at a 10% concentration you will have to pay around 420 rubles, and 60 capsules of Mildronate at a dosage of 500 milligrams will cost approximately 650 rubles.

Analogues

The most acceptable substitutes for Mildronate are: Meldonium (about 170 rubles for 10 ampoules), Cardionat (within 260 rubles for 5 ampoules), Idrinol (the most expensive analogue, the cost of which is within 700 rubles for 5 ampoules).

It is important to understand that any drug, treatment regimen, duration, dose and analogue should be selected only by a qualified medical specialist who carefully studies the patient’s outpatient record, his tests and condition.

The instructions presented on the website are for informational purposes only; you should not self-medicate, diagnose yourself or prescribe medications. This can only worsen your condition.

Is it possible to inject Mildronate intramuscularly and intravenously?

Mildronate is a metabolic medicine designed to restore the balance of oxygen inside cells and quickly restore energy reserves. To the question - can Mildronate be injected intramuscularly, the instructions supplied with the drug give the answer. In it, the manufacturer claims that the medication solution is intended for intravenous, intramuscular and parabulbar administration.

Indications

Mildronate is administered intravenously for:

• chronic heart failure;
• cardiomyopathy;
• retinal thrombosis;
• cerebrovascular insufficiency;
• retinopathy.

The drug is indicated to increase performance and maintain the body during severe physical and mental stress. The active components of this medication may be of interest to all heart patients and post-stroke patients. The medicine contains meldonium, which supports the functioning of the heart and brain in the body. Thanks to its effects, the patient’s performance improves and the neurological functions of the body improve.

How does the medicine work?

After entering the blood and tissues, the components of the drug reach their maximum concentration in the blood plasma. The medication increases heart contractions, supports myocardial function, and improves cerebral circulation. Mildronate can be injected intramuscularly to redistribute blood masses during ischemia. As a result of treatment, the concentration of carnitine stabilizes and the formation of necrotic areas slows down.

From the bloodstream, the active substances of the product are distributed throughout the cellular structures of the tissue.

• improve the functionality of the central nervous system;
• relieve paresis;
• improve the body's reflexes.

Mildronate, when administered intramuscularly, has a beneficial effect on the entire nervous system.

Mildronate injections intramuscularly reduce the body's rehabilitation for various heart diseases several times. The active substances of the drug enhance the synthesis of butyrobetaine, which has a vasodilating effect. The drug improves the functioning of brain structures, blood supply to the brain, and increases physical performance.

The drug eliminates functional disorders in chronic alcoholism and eliminates angina attacks. As a result of treatment, heart function stabilizes. The medication is advisable to use in the treatment of stroke and heart disease.

Methods of drug administration

Intravenously

Injection of Mildronate solution when administered intravenously does not cause adverse reactions. The medicine is well tolerated by the body. However, when administered intramuscularly, the active substances of the drug are absorbed more slowly. This feature should definitely be taken into account if Mildronate is injected intramuscularly.

Parabulbar method of administration

The parabulbar method of administering the solution is that the injection is made into the lower eyelid. This method of drug administration is used in ophthalmic practice. The needle is directed into the eyeball located near the fiber. The injection is quite painful. The medicinal solution must be administered very carefully.

Intramuscularly

Intramuscular administration of the drug can be replaced by taking capsules and tablets. One tablet of the product contains 250 mg of meldonium dihydrate. The active substance has a metabolic effect. You need to take the drug per day at a dose of 500 mg - that’s two capsules per day. The daily dose is divided into two doses or taken once if necessary.

The drug Mildronate is administered intramuscularly to many patients suffering from heart failure. The price of medication, on average, varies between 665 rubles.

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Polina and the world

It has not been determined whether the drug is excreted into breast milk. Many people are interested in whether Mildronate can be injected intramuscularly rather than intravenously. For chronic cerebral circulatory failure (dyscirculatory encephalopathy), 0.5 g (5 ml of Mildronate®) IM or IV once a day for 10 days, then 0.5 g orally.

What is the difference between the capsule and liquid form of the drug? Can Mildronate® be used during breastfeeding? Mildronate can be called a kind of universal fighter: this drug is prescribed for a variety of ailments. You can inject it without fear for the purity of your name in big sport and professional honor: mildronate is not a dope. But for cardiovascular diseases, you will need to administer mildronate intravenously - 1 gram of the active substance twice a day. You will have to be patient: the course of treatment lasts 4–6 weeks.

Despite its tempting properties, injections of mildronate must be done with great caution: it is known to cause side effects. It is thanks to this effect that mildronate is so popular in bodybuilding: the faster the body recovers, the more striking results can be obtained during the next workout.

The difference lies in the bioavailability of meldonium and the method of administration of the drug: enteral or parenteral route of administration, which, in turn, affects the speed of achieving the effect.

What is the clinical effect of the drug based on? Can Mildronate® improve an athlete's athletic performance? Can Mildronate® be taken with other medications? Can Mildronate® be used during pregnancy? No clinical studies have been conducted on the safety of the drug during pregnancy.

If treatment with Mildronate® is necessary for the mother, stop breastfeeding. Of particular note is the safety of using the drug Mildronate®; this is one of the important factors explaining its wide acceptance among doctors and patients.

Does Mildronate® affect the ability to drive? Has the drug been standardized according to international quality standards? Where is the drug produced? The drug is produced in production facilities in the countries of the European Union - in Latvia and Slovakia.

Mildronate and alcohol

As a result of its use, the body acquires the ability to withstand stress and quickly restore energy reserves. Pharmacokinetics: Bioavailability of the drug after intravenous administration is 100%. The maximum concentration in blood plasma is achieved immediately after its administration. The excretion of the drug Mildronate® in milk and its effect on the health of the newborn have not been studied, therefore, if use is necessary, breastfeeding should be stopped.

5 ml in a clear glass ampoule with a line or break point. Two cell packaging (pallets) along with instructions for use in a cardboard pack. The instructions for use say: the drug can be taken orally - in the form of capsules, or, if injections are not scary, it can be injected intravenously - then ask pharmacists for it in ampoules. This drug is very popular among athletes and bodybuilders. Moreover, the instructions for use recommend its administration both during preparation for competitions and on days of maximum physical activity.

It is also interesting that thanks to the drug, you can restore the body in a much shorter time, make it stronger, and therefore get much better results. During mental and physical stress, you can administer 250 mg of the medicine as much as 4 times a day! Injecting veins so often, especially since the course of treatment lasts 12 days, you must admit, it’s still a test.

And doctors themselves are wary of this idea. Firstly, the effectiveness of the drug is significantly reduced. Its properties are such that it can be used in dozens of cases. This is a universal drug that accelerates metabolism at the cellular level, which allows you to quickly recover from any damage or disease. By the way, the drug is not a doping, so its use in any sport is completely legal.

Mildronate is a drug that is prescribed to patients for a variety of ailments. Like any other medicine, Mildronate should not be taken with alcoholic beverages.

Mildronate intramuscularly

Mildronate is a drug that is prescribed to patients for a variety of ailments. Its properties are such that it can be used in dozens of cases. This is a universal drug that accelerates metabolism at the cellular level, which allows you to quickly recover from any damage or disease. It is thanks to this effect that mildronate is so popular in bodybuilding: the faster the body recovers, the more striking results can be obtained during the next workout.

The drug Mildronate: indications for use

As mentioned above, Mildronate can be used in a variety of cases. As a rule, it is prescribed to those who suffer from heart or vascular diseases, as well as in cases of cerebrovascular accidents.

Mildronate has gained particular popularity in the sports field - both weightlifters and other athletes enjoy using it. By the way, the drug is not a doping, so its use in any sport is completely legal. Thanks to Mildronate, your body will have time to recover after heavy loads, so your athletic results will be higher and higher. The main thing is to follow the recommended dosages and courses of administration, since with prolonged use addiction develops and the drug loses its effectiveness.

How to take Mildronate?

Today in pharmacies you can find Mildronate, produced in one of two possible forms: either in capsules for oral administration or in ampoules for intravenous administration. It has been proven that the drug administered intravenously is much more effective than taking capsules orally (the effectiveness increases approximately 2 times). The instructions for the drug indicate that it can also be administered parabulbarly - that is, through an injection under the eyeball.

Many people are interested in whether Mildronate can be injected intramuscularly rather than intravenously. Based on the fact that the instructions for this drug do not indicate otherwise, this method of administration is possible. However, since it was not provided by the manufacturer, there is a possibility that its effectiveness will be reduced and approximately equal to that which can be obtained by taking capsules orally. Moreover, the official website of the drug contains information that it is dangerous to use it intramuscularly, since it is irritating and can lead to local pain and allergic reactions.

Thus, when considering the possibility of intramuscular administration of Mildronate, you should, first of all, rely on the advice of your doctor and common sense. Uncontrolled actions in this case can be very dangerous for your health! It is not recommended to deviate from the instructions given by the manufacturer of the drug.

Mildronate: dosage

For athletes, Mildronate is usually prescribed to be taken immediately before training, 0.5-1 g orally 2 times a day. The course during the competition period can last a day, and during the preparation period – 2-3 weeks.

Mildronate and alcohol

Like any other medicine, Mildronate should not be taken with alcoholic beverages. Its instructions contain information that it is recommended to be used for the complex treatment of people with alcoholism, but this should not be done directly on the day of drinking alcohol.

Can mildronate be administered intramuscularly?

Mildronate can be called a kind of universal fighter: this drug is prescribed for a variety of ailments. Its active substance, meldonium, accelerates intercellular metabolism, helping the body cope with many ailments and recover from serious stress.

The instructions for use say: the drug can be taken orally - in the form of capsules, or, if injections are not scary, it can be injected intravenously - then ask pharmacists for it in ampoules. But is it permissible to administer mildronate intramuscularly?

Mildronate: one answer to a thousand troubles

The scope of action of this medicine is indeed wide.

The instructions for use of mildronate state that it is necessary for:

• speedy recovery after heavy physical and mental stress;
• oxygen saturation of cells;
• creating a barrier to toxins that accumulate in cells;
• toning the whole body;
• increasing the frequency of myocardial contractions;
• improving blood circulation;
• elimination of nervous system disorders, especially with long-term alcoholism;
• strengthening muscles.

That is why there are a lot of diagnoses for which doctors prescribe mildronate:

• chronic heart failure;
• acute ischemia;
• angina pectoris, myocardial infarction;
• circulatory disorders.

It is also often offered for reduced performance, rapid fatigue, and constant mental and physical stress.

It is noteworthy that the active ingredient of the drug, meldonium, has the same structure as a substance with the complex name gamma-butyrobetain, which can be found in every cell of our body. If there is a shortage of it, it is recommended to administer mildronate. According to the instructions for use, any analogue of mildronate has similar properties, of which, by the way, there are many in pharmacies: melfor, vasomag, medatern, idrinol...

Why do bodybuilders need mildronate?

What is metabolism?

The properties of the drug, which play into the hands of athletes, are really useful. Mildronate:

• ensures oxygen delivery to all cells;
• prevents the accumulation of saturated fatty acids in cells;
• helps to better nourish muscles;
• relieves tension, accumulated fatigue, increases performance;
• serves as a guarantee of training effectiveness;
• protects the heart from increased stress.

It is also interesting that thanks to the drug, you can restore the body in a much shorter time, make it stronger, and therefore get much better results.

Dosage of the drug

Mildronate is produced in capsules or ampoules. Swallowing or injecting is a personal choice, and yet, according to some studies, if the drug is injected intravenously, its effectiveness increases by about 2 times. That is why the instructions for use devote a lot of space to indicating the dosage of the medicine: it varies not only for different diseases, but also when using different dosage forms.

For example, athletes take 0.5–1 gram of medication orally twice a day. The course of admission is 3 weeks during preparation for competitions and 10–14 days during the active period of sports achievements and achievements.

During mental and physical stress, you can administer 250 mg of the medicine as much as 4 times a day! Injecting veins so often, especially since the course of treatment lasts 12 days, you must admit, it’s still a test. Therefore, it is better to take it in capsule form.

But for cardiovascular diseases, you will need to administer mildronate intravenously - 1 gram of the active substance twice a day. You will have to be patient: the course of treatment lasts 4–6 weeks.

Can the drug be administered intramuscularly? The instructions for use compiled by the manufacturer do not provide for this method of use. And doctors themselves are wary of this idea. Firstly, the effectiveness of the drug is significantly reduced. In addition, many manufacturers warn that medicine administered intramuscularly can cause allergies, and such an injection itself can be called very painful. Therefore, it is better to abandon the idea of ​​​​doing an intramuscular injection: the game is not worth the candle.

Contraindications and side effects

Despite its tempting properties, injections of mildronate must be done with great caution: it is known to cause side effects. Among them are muscle agitation, rapid heartbeat, itching, rash and redness on the skin, swelling at the injection site. If at least one of the side effects manifests itself, this is a serious reason to stop taking the drug and consult a doctor.

In addition, it has many contraindications.

• chronic kidney and liver diseases;
• age under 18 years;
• period of pregnancy and breastfeeding.

In a separate line, manufacturers warn against taking the medicine while drinking alcohol. Remember: mildronate and alcohol are completely incompatible!

Mildronate injections

Mildronate is a drug with metabolic activity, which improves the energy supply of cells and tissues. The positive effect of this drug on metabolism and the elimination of energy deficiency has made it possible to use Mildronate for many chronic diseases of the cardiovascular, respiratory, and nervous systems. It is also prescribed for the treatment of certain ophthalmological pathologies, increasing endurance, both physical and intellectual.

There are several forms of release of Mildronate, each of which can be prescribed based on the severity of symptoms, the patient's condition or his personal preferences. Doctors usually prescribe Mildronate injections in cases where it is necessary to quickly achieve a therapeutic effect or if the patient cannot take pills. Usually, the course of treatment can be continued in the future, switching from the injection to the oral form of the drug.

Description of the active substance

According to the instructions for use of Mildronate, the active ingredient in its composition is meldonium or trimethylhydrazinium propionate dihydrate. In structure, it is an analogue of gamma-butyrobetaine, which is present in all human cells. The mechanism of action of meldonium is to block the production of carnitine, as a result of which the synthesis of gamma-butyrobetaine increases. It promotes vasodilation and more efficient blood supply to tissues, especially those under hypoxic conditions.

The drug protects cells from the aggressive effects of catabolic products and toxins, accelerating the elimination of these agents from the body. With ischemia of tissues and organs (for example, myocardium, brain, retina), meldonium changes the blood flow ratio in favor of areas with hypoxia. Thus, its anti-ischemic and antihypoxic effect is manifested.

In conditions of acute lack of myocardial blood circulation, Mildronate helps slow down the formation of necrotic damage and shortens the rehabilitation period. For angina pectoris, the drug reduces the number of attacks of anginal pain and increases cardiac output. Thanks to it, the stimulation of neurons increases, the motor sphere and physical endurance are activated. It also has an anti-stress effect.

Meldonium improves the course of the rehabilitation period in patients who have suffered vascular, inflammatory diseases of the brain or had injuries to the central nervous system. It reduces movement disorders (paresis), improves coordination, and reduces the severity of vegetative manifestations. The use of the drug helps improve the condition of patients with alcohol dependence and reduces the manifestations of withdrawal syndrome.

Pharmacokinetics

The maximum plasma concentration of Mildronate for injection is achieved almost immediately after its parenteral administration. It is quickly distributed in tissues and binds to blood plasma proteins. The bioavailability of the drug is 100%.

Attention! The drug partially penetrates the hematoplacental barrier, and has also been found to pass into breast milk.

Metabolism of Mildronate occurs in the liver

The drug and its metabolites are excreted primarily by the kidneys. The half-life is 3-6 hours.

Indications

What is Mildronate used for, and when can it be useful? Indications for the use of the drug are the following pathological conditions:

• cardiovascular pathology: chronic ischemic heart disease, angina pectoris, myocardial infarction, chronic heart failure;
• dishormonal cardiomyopathy;
• vegetative-vascular dystonia;
• chronic circulatory disorders in the brain;
• cerebral stroke;
• pathology of peripheral arterial vessels;
• postoperative recovery period;
• bronchial asthma and chronic obstructive pulmonary disease as a component of complex treatment;
• eye diseases of various origins: hemorrhage in the retina and vitreous body of the eye, retinopathy (hypertensive and diabetic), thrombosis of the central retinal vein, impaired blood supply to the retina.
• chronic alcoholism and withdrawal syndrome in alcohol addicts in combination with other types of treatment;
• high physical fatigue and overstrain;
• low productivity of physical and intellectual labor.

Attention! For diseases of the organ of vision, the use of Mildronate injections only parabulbarly is indicated.

In case of cardiovascular pathology, Mildronate injections are part of the complex therapy of these diseases and cannot replace constant treatment with basic drugs

Among the indications for the use of Mildronate, sports training has also found its niche in order to increase endurance, for quick recovery after hard and long-term sports.

How to take the drug?

Mildronate solution has a meldonium concentration of 10%. It is produced in ampoules of 5 ml. Accordingly, 1 ml of solution contains 100 mg of meldonium, and one ampoule contains 500 mg. The box contains 10 ampoules. The drug is prescribed 1 or 2 times a day. The drug solution can be administered in several ways:

• intramuscularly;
• intravenously;
• parabulbar (near the eyeball).

Mildronate is usually administered intravenously in a jet manner, this way the desired effect can be achieved faster. If there is no urgent need for immediate action of the drug, then it can be injected into a vein using a dropper.

The drug in the form of a solution does not need to be diluted before administration.

Mildronate solution is available in a sufficient concentration of the active substance and does not require additional dilution. This applies to all methods of injection delivery of the drug. However, doctors may prescribe its administration, for example, with saline solution. If Mildronate is nevertheless diluted, then the absolute amount of the active substance will not change, only its concentration will decrease, which may affect the speed of onset of the drug’s action.

In cases where rapid action is not required, Mildronate can be diluted. For this purpose only, it is better to use a 0.9% sodium chloride solution (saline). Mixing with other solvents may affect the properties of the drug, which is extremely undesirable.

Mildronate activates nervous activity, so it should be taken at least 4-6 hours before bedtime. Otherwise, sleep disturbance in the form of insomnia may occur. The daily dose can be taken in one injection or divided into two doses.

Dosage for various pathologies

The dose of the drug depends on the specific disease and is selected by the doctor individually:

• Unstable angina and myocardial infarction. In such cases, intravenous administration of the drug is indicated, since these conditions are acute and require immediate intervention. 5-10 ml of Mildronate are administered intravenously. If injections are poorly tolerated, the entire dose is administered once; in other cases, dividing it into two injections is indicated. The duration of parenteral administration of drugs ranges from 1 to 10 days. In the future, you can switch to oral forms of Mildronate and take it in a general course lasting up to 4-6 weeks.
• Chronic circulatory failure. Use 5-10 ml IV once a day or 5 ml twice a day IM. The course lasts up to 2 weeks with a transition to syrup or tablets.
• Ophthalmological pathology. In this case, Mildronate is used parabulbarly at 0.5 ml per day (50 mg meldonium) for 10 days.
• Brain stroke in the acute phase. To achieve a quick effect from the use of the drug, it is administered intravenously at a dose of 5 ml per day for 10 days. You can also inject it intramuscularly at a dose of 500 mg once a day for 2-3 weeks.
• Chronic cerebrovascular insufficiency. For this pathology, the drug is administered either intramuscularly or in tablet form. Inject 5 ml of solution intramuscularly 1 time for 14 days. Reception is extended if necessary up to 4 weeks.
• Dyshormonal cardiomyopathy. Apply 5-10 ml intravenously in one injection per day or 5 ml intramuscularly 2 times a day. The course is 14 days, and if oral administration is continued, it is recommended to take Mildronate for another 2 weeks.
• Chronic alcoholism. Patients receive Mildronate intravenously, 5 ml 2 times a day to relieve neurological symptoms. Continue therapy for up to one week.
• Increased fatigue during periods of high physical and intellectual stress. There is no urgent need for parenteral administration of Mildronate for such indications, but it all depends on which method is more acceptable to the patient and how quickly the effect is expected. The drug is taken intramuscularly, 1 ampoule 1 or 2 times a day. It is also possible to take Mildronate intravenously in a similar dosage regimen. The course of treatment is up to 2 weeks. If there is a need, it can be repeated after another 2-3 weeks.

If, in chronic cerebrovascular accidents, there are swallowing disorders or digestive problems, you should choose the parenteral route of administration of Mildronate

Interaction

Mildronate, interacting with other drugs, can cause both desirable and dangerous reactions in the body. Many patients are interested in whether it is possible to combine meldonium with other drugs. Only a doctor can give a definite answer to this question.

Meldonium increases efficiency:

• antiplatelet agents;
• anticoagulants;
• bronchodilators;
• antiarrhythmics;
• antianginal drugs;
• diuretics.

When prescribing Mildronate, always warn your doctor about taking any medications and about concomitant diseases.

The drug potentiates the effect of beta blockers and cardiac glycosides. Particular caution should be taken when taking Mildronate with the following drugs:

• alpha blockers;
• nitrates;
• calcium channel antagonists;
• peripheral vasodilators.

Taking these drugs together can lead to a sharp decrease in blood pressure and tachycardia.

Contraindications

According to the instructions for use of the drug, it is not prescribed in the following cases:

• pregnancy;
• lactation period;
• children under 12 years of age;
• increased intracranial pressure;
• allergy or the presence of individual hypersensitivity to meldonium.

Side effects and drug overdose

Typically, patients experience a high degree of tolerability of the drug, but sometimes there are cases of adverse reactions to Mildronate:

• skin allergic manifestations in the form of rash, urticaria, rarely - angioedema;
• dyspepsia;
• fluctuations in blood pressure;
• increased heart rate;
• insomnia and psychomotor agitation;
• weakness;
• change in blood count (increased level of eosinophils).

special instructions

In patients who have serious kidney and liver diseases with insufficiency of the functions of these organs, biochemical blood parameters should be monitored. If long-term use of meldonium is necessary, consultation with the attending physician is required to adjust the dose of the drug.

A person taking Mildronate may be allowed to drive vehicles and operate machinery, since the drug does not cause a slowdown in reactions. Elderly patients should reduce the therapeutically effective daily dose.

Application in sports

Due to Mildronate's ability to increase the absorption of oxygen by tissues, it can be recommended for increasing tolerance to physical activity. It improves nutrition of the myocardium and peripheral muscles. This helps reduce fatigue and speed up recovery after training.

Until recently, meldonium was not considered doping, but since 2016 it has been included in the list of drugs that are considered doping in sports

Storage conditions

After opening the ampoule, the solution cannot be stored under any circumstances. A refrigerator is also not suitable for this purpose. After 20 minutes or more have passed after the seal has been broken, the ampoule should be discarded.