home Audience 5 Detralex - official* instructions for use. Auxiliary substance for polishing tablets. Directions for use and doses

Detralex - official* instructions for use. Auxiliary substance for polishing tablets. Directions for use and doses

Instructions:

Clinical and pharmacological group

01.074 (Venotonic drug)

Release form, composition and packaging

Orange-pink, oval, film-coated tablets; at the break - from pale yellow to yellow color, heterogeneous structure.

Excipients: gelatin, magnesium stearate, microcrystalline cellulose, sodium carboxymethyl starch, talc, purified water.

Film shell composition: macrogol 6000, sodium lauryl sulfate, orange-pink premix for film shell (glycerol, magnesium stearate, hypromellose, yellow iron oxide, red iron oxide, titanium dioxide).

15 pcs. - blisters (2) - cardboard packs. 15 pcs. - blisters (4) - cardboard packs.

pharmachologic effect

A drug used for venous circulation disorders. Detralex® has venotonic and angioprotective properties. The drug reduces the distensibility of veins and venous stasis, reduces capillary permeability and increases their resistance. results clinical trials confirm the pharmacological activity of the drug in relation to indicators of venous hemodynamics.

A statistically significant dose-dependent effect was demonstrated for the following venous plethysmographic parameters: venous capacity, venous distensibility, venous emptying time.

The optimal dose-effect ratio is observed when taking 2 tablets.

Increases venous tone: using venous occlusion plethysmography, a decrease in venous emptying time has been shown. In patients with signs of severe microcirculation disorders, there is a (statistically significant) increase in capillary resistance, assessed by angiostereometry, after treatment with Detralex, compared with placebo.

Proven therapeutic effectiveness in the treatment of functional and organic chronic venous insufficiency lower limbs, as well as in proctology in the treatment of hemorrhoids.

Pharmacokinetics

Metabolism

The drug undergoes active metabolism, which is confirmed by the presence of phenolic acids in the urine.

Removal

T1/2 of diosmin is 11 hours.

Diosmin is excreted from the body mainly in feces. 14% is excreted by the kidneys dose taken.

Dosage

Overdose

No cases of overdose of Detralex® have been reported.

Drug interactions

Drug interactions The drug Detralex® has not been described.

Use during pregnancy and lactation

To date there have been no reports of any side effects when using the drug in pregnant women.

It is unknown whether diosmin is released from breast milk in humans, therefore it is not recommended to prescribe the drug during lactation.

In experimental studies, no teratogenic effects of Detralex were observed.

Side effects

Frequency adverse reactions presented in accordance with the following gradation: very often (>1/10), often (>1/100,<1/10), умеренно (>1/1000, <1/100), редко (>1/10 000, <1/1000), очень редко (<10 000), включая отдельные сообщения.

From the digestive system: often - diarrhea, nausea, vomiting, dyspepsia.

From the side of the central nervous system: rarely - dizziness, headache, general malaise.

Dermatological reactions: rarely - rash, itching, urticaria.

Storage conditions and periods

List B. The drug should be stored out of the reach of children. Shelf life - 4 years. Do not use after the expiration date indicated on the package.

Indications

Symptomatic treatment of venous-lymphatic insufficiency:

- feeling of heaviness in the legs;

- "morning fatigue" of the legs.

Symptomatic treatment of acute hemorrhoids.

Contraindications

- hypersensitivity to the components of the drug.

special instructions

In case of exacerbation of hemorrhoids, the prescription of this drug does not replace the specific treatment of other anal disorders. The duration of treatment should not exceed the recommended periods. If symptoms do not disappear after short therapy, a proctological examination should be performed and the therapy reviewed.

In the presence of venous circulation disorders, the maximum effect of treatment is ensured by a combination with a healthy, well-balanced lifestyle, in which it is advisable to avoid long exposure to the sun, long periods of standing, and also reduce excess body weight, take walks and, in some cases, wear special stockings , improving blood circulation.

Impact on the ability to drive vehicles and operate machinery

The drug does not affect the ability to drive vehicles or perform work that requires a high speed of psychomotor reactions.

Conditions for dispensing from pharmacies

The drug is available with a doctor's prescription.

Registration numbers

. tab., cover film coating, 450 mg+50 mg: 30 or 60 pcs. P N011469/01 (2026-06-09 - 0000-00-00)

Tradename

Detralex®

Dosage form

Compound

Active substance:

Excipients:

Film shell:

Sodium lauryl sulfate 0.130 mg, premix for film shell of orange-pink color OY-S-8761, consisting of: glycerol 1.628 mg, hypromellose 27.039 mg, macrogol 6000 0.651 mg, magnesium stearate 1.628 mg, red iron oxide dye 0.211 mg, titanium dioxide 5.205 mg, iron dye yellow oxide 0.633 mg.

macrogol 6000 1,300 mg. The mass of the film-coated tablet is 1378.425 mg. 1) Taking into account the average moisture content of the purified, micronized flavonoid fraction - 4%, (or 40 mg per tablet), the amount of substance per tablet is 1040.00 mg.

Description

PHARMACOLOGICAL PROPERTIES

Pharmacodynamics

venous capacity,
venous distensibility,

Pharmacokinetics

Pharmacotherapeutic group

ATX code: C05CA53

INDICATIONS AND CONTRAINDICATIONS

Indications

pain;
spasms of the lower extremities;
"tired" legs.

swelling of the lower extremities;
venous trophic ulcers.

Contraindications

Pregnancy:

Lactation:

METHOD OF APPLICATION AND DOSES

1 tablet per day.

SIDE EFFECT

Side effects of the drug

<1/10); нечасто (≥1/1 000, <1/100); редко (≥1/10 000, <1/1 000); крайне редко (<1/10 000), неуточненной частоты (частота не может быть подсчитана по доступным данным).

Uncommon: colitis. Unspecified frequency: abdominal pain.

From the skin: Rarely: rash, itching, urticaria.

Overdose

Not noted.

SPECIAL INSTRUCTIONS

Release form

Storage

Best before date

Vacation conditions

Available without a prescription.

Detralex(Detralex).

Pharmacological group

Angioprotector, venotonic agent.

Release form and composition

Detralex is produced in the form of coated tablets.

1 tablet contains 500 mg of micronized flavonoid fraction, which includes diosmin - 450 mg, and hesperedin - 50 mg.

Excipients: microcrystalline cellulose, sodium carboxymethyl starch, gelatin, magnesium stearate, purified water, talc.

The film shell consists of macrogol 6000, sodium lauryl sulfate, an orange-pink premix for the film shell (magnesium stearate, glycerol, hypromellose, yellow iron oxide (E172), titanium dioxide (E171), red iron oxide.

The tablets are packaged in blisters of 15 pieces, 2 or 4 blisters in a cardboard box. Instructions included.

Description of the drug Detralex

The tablets are oval in shape and pink-orange in color; on the fracture, the contents are heterogeneous, pale yellow in color (coloring to yellow is allowed).

pharmachologic effect

Pharmacodynamics
Detralex has angioprotective and venotonic properties. It maintains the tone (tension) of the vascular wall, preventing it from stretching, which reduces the release of plasma and proteins from the bloodstream into the surrounding tissues and reduces the fragility of capillaries. This leads to a reduction in congestion. This drug has a dose-dependent effect: the optimal therapeutic effect is observed when taking 2 tablets.

Pharmacokinetics
The half-life of Detralex from the body is 11 hours.

The drug is excreted mainly through the intestines. Only 14% of the administered dose of Detralex is excreted in the urine.

Indications for use of the drug Detralex

1. Symptomatic treatment and prevention of chronic venous insufficiency

Venous insufficiency includes such manifestations as a feeling of fatigue and heaviness in the legs, swelling of the lower extremities, pain in the legs, impaired sensitivity in the form of paresthesia, convulsions, and trophic disorders.

Chronic venous insufficiency is a group of symptoms resulting from impaired blood flow through the veins of the lower extremities and changes in the permeability of the vascular wall. It develops more often in women. The disease occurs when the valves that close the lumen of the veins cannot prevent the reverse flow of blood due to increased pressure on them for various reasons. As a result, blood pressure on the wall of the venous vessels increases, which leads to its stretching. In this case, the permeability of the vascular wall for blood and plasma proteins increases, swelling and compaction of adjacent tissues appear. Foci of ischemia (insufficient blood supply with oxygen) occur in places where small vessels are compressed, which contributes to the formation of trophic ulcers.

The main risk factors for the development of chronic venous insufficiency include:

weakness of the muscular wall of the veins (hereditary);
overweight and obesity;
pregnancy and childbirth;
long-term constant work in a standing or sitting position, with limited movement (cooks, office workers, surgeons, etc.);
chronic constipation;
fluctuations in hormonal levels in women (contraception with hormonal drugs, hormonal treatment during menopause, etc.);
wearing tight underwear and clothing, corsets.

The following stages of development of varicose veins are distinguished:

Stage 0 – no major symptoms upon examination.

Stage I- “morning fatigue” of the legs, complaints of intermittent swelling in the evenings (disappear in the morning).

Stage II– persistent swelling, skin pigmentation disorders; some areas of the skin become thicker, the skin above them cannot be folded (lipodermatosclerosis), redness appears on the skin, accompanied by itching and weeping (eczema).

Stage III– the formation of trophic ulcers (active or healed), difficult to treat with medication.

All stages of the disease are accompanied by pain of varying intensity and the presence of evening cramps. Patients note a feeling of tingling, crawling, and slight numbness.

In the treatment of the disease in the early stages, compression with elastic bandages and compression hosiery is used, and the prescription of medications that increase venous tone (for example, Detralex), physiotherapeutic treatment and rehabilitation in sanatoriums.

2. Preoperative preparation and postoperative treatment of chronic venous insufficiency

3. Symptomatic treatment of hemorrhoids
Hemorrhoids are dilation of the veins of the anus and lower rectum. Dilated veins filled with blood become visible as separate nodes. Based on the location of the nodes, external and internal hemorrhoids are distinguished. It can be acute (accompanied by the development of complications) and chronic, occurring without complications.
Hemorrhoids are caused by:

sedentary lifestyle, work in a sitting and standing position (programmers, miners, teachers);
prolonged constipation;
pregnancy, childbirth, uterine bends;
abuse of alcohol, spicy, salty, smoked foods;
inflammatory diseases of the pelvic organs.

One of the first symptoms is a feeling of itching in the anus. The development of the disease is accompanied by the appearance of pain, bleeding from the rectum during bowel movements, streaks of blood in the stool, the appearance and further loss of nodes (they can become pinched during bowel movements and become inflamed).

If symptoms occur, you should consult a doctor. In the absence of complications, treatment is carried out using conservative methods. Positive results are achieved with complex treatment: adequate regimen (physical activity), dietary nutrition rich in fiber, drug therapy. To reduce the intensity of itching and pain, rectal suppositories are used - topically into the rectum. To reduce the stretching of the venous wall, various venotonics are used - orally through the mouth, including the drug Detralex.

Contraindications to the use of Detralex

Increased individual sensitivity to the constituent components of the drug in the form of allergic reactions.

Detralex dosage regimen

For treatment venous circulation insufficiency Detralex tablets must be taken orally, 2 pieces each. 2 times a day, during meals. After 7 days of taking the drug, it is necessary to reduce the dose to 2 tablets per day (1 tablet in the afternoon and in the evening). The duration of treatment is determined by the attending physician.

Acute attack of hemorrhoids: for 4 days you need to take 3 tablets in the morning and evening with meals (6 tablets in total per day), then over the next 3 days the dose is reduced to 2 tablets in the morning and evening (4 tablets in total per day).

Chronic course of hemorrhoids: for 1 week, Detralex is taken 2 tablets 2 times a day with meals, then the dose is reduced to 2 tablets per day, in one dose with meals.

The average course of treatment is 2-3 months, depending on the severity of the disease and determined by the attending physician.

Side effects of the drug Detralex

From the gastrointestinal tract, nausea and stomach discomfort, vomiting and diarrhea may be observed.
From the central nervous system, headache and dizziness may occur.
Very rarely, allergic manifestations such as rash, itching, and urticaria may occur on the skin.

Urticaria is an acute allergic reaction characterized by the rapid appearance of blisters. Accompanied by itching.

If any side effects occur, you should consult your doctor about the need to adjust treatment.

Symptoms of an overdose of Detralex

During clinical trials of the drug Detralex, cases of its toxic effects on the body and overdose were not registered.

Interaction of the drug Detralex with other drugs
means

The effect of Detralex on the medicinal effect of other pharmaceuticals was not detected.

Special instructions for the use of the drug Detralex

If, after a short course of treatment for acute hemorrhoids, symptoms of the disease persist, you should consult a doctor for additional examination and change of medication.

Pregnancy and breastfeeding
In animal experiments, no negative effects on the embryo were observed when taking the drug Detralex. There were no data on the occurrence of side effects in pregnant women, as well as in children during breastfeeding. However, taking the drug during pregnancy and breastfeeding is not recommended due to insufficient research and data.

Children
Detralex has not been used in the treatment of children. There are no data on its effects, possible side effects and overdose.

Driving vehicles and operating machinery
The drug Detralex does not affect the speed of mental and physical reactions.

Analogues of the drug Detralex

Full analogues (generics):

Venarus(Venarus) is a generic drug with the same active ingredients (diosmin and hesperidin). The principle of action is the same as that of Detralex. Release form: coated tablets. Use during lactation is contraindicated. Shelf life - 2 years. Manufacturer: FP Obolenskoye CJSC.
Venozol(Venozolum) - a drug with the main active ingredients - diosmin and hesperedin. pharmachologic effect similar to Detralex. Release form: tablets, gel and cream. Manufacturer: VIS LLC.

Partial analogues:

Phlebodia 600 (Phlebodia 600) - available in tablet form. The active ingredient, diosmin, has a medicinal effect similar to Detralex (increases the tone of the venous wall, improves blood flow, normalizes the permeability of vascular walls). Manufacturer: Innotera Shuzi FRA.
Vasocket(Vasocet) comes in the form of oblong yellow tablets. The active substance (diosmin) reduces the distensibility and increases the tone of the veins, thereby preventing the appearance of edema. Manufacturer: Stragen/Weimer Pharma, Germany.

Other venotonics:

Antistax is a bioflavonoid (active ingredients are biologically active substances) drug that belongs to the group of venotonic drugs. Available in tablet form. Manufacturer: Boehringer Ingelheim, Germany.

Troxevasin is produced under the trade names Venoruton, Troxerutin. It is a semi-synthetic derivative of rutin. Improves the condition of the walls of blood vessels and has an anti-edematous effect. Main forms of release: capsules, gel for topical use, solution for injection in ampoules. Manufacturer: Farmakhim BOL.

Anavenol is a combined venoprotective drug. Available in the form of film-coated tablets. Some antibiotics can enhance the therapeutic effect of anavenol (dopamine, etc.). The side effects of anavenol manifest themselves in the form of bleeding, dizziness, and nausea. The use of anavenol is contraindicated in children under 15 years of age. Manufacturer: Zentiva CZECH.

Venoruton(Venoruton) is an angioprotective drug, the active ingredient is hydroxyethylrutoside. Release form: tablets and gel for external use. Prescription in the second and third trimester of pregnancy is possible. Manufacturer: Novartis, Switzerland.

Ginkor fort(Ginkor Fort) has a venotonic and venoprotective effect. It contains standardized extract of ginkgo biloba, heptaminol hydrochloride and troxerutin. Available in the form of capsules and gel for external use. In case of overdose, blood pressure may increase. According to indications, the drug can be prescribed in the second and third trimesters of pregnancy. Contraindicated in hyperthyroidism and concomitant use of MAO inhibitors. Manufacturer: Bofur Ipsen, France.

Reviews about the drug Detralex

There are different reviews about the drug Detralex. For some it helps 100%, for others it turns out to be useless. But still, the majority of patients who took Detralex respond positively to this drug. Patients note that within a short period from the start of treatment, symptoms of venous insufficiency, such as pain, swelling, heaviness in the legs, become less pronounced or practically disappear. When treating hemorrhoids, discomfort is also relieved. This significantly improves the level of emotional and physical comfort of patients. Side effects from the drug Deralex occurred only in a small number of patients.

Doctors note that this effect from the use of the drug Detralex is achieved thanks to its unique medicinal formula and production technology. Very small particles of active ingredients are easily absorbed by the body. But the best result, according to doctors, is achieved as a result of treatment with several repeated courses as part of complex therapy for venous insufficiency of the lower extremities and hemorrhoids. Do not forget about the regime, adequate physical activity, diet and other medications that help in the fight against the disease.

Storage conditions and periods

The drug Detralex belongs to list B of pharmacological drugs (potent drugs, the use and storage of which is carried out with caution). Detralex must be stored out of the reach of children!

Storage of the drug Detralex is carried out in a dry place, at a temperature not exceeding 30 o C.
The shelf life is 4 years (subject to storage conditions).
It is not recommended to use a drug that has expired.

Conditions for dispensing the drug Detralex in pharmacies

The drug is sold in pharmacies with a doctor's prescription.

Price for the drug Detralex

The drug Detralex film-coated tablets, 500 mg, can be bought in pharmacies (Moscow) at an average price of 270 rubles for a package of 30 pieces, 1270 rubles for a package of 60 pieces.

Manufacturer

"Servier Industry Laboratories", France. Before use, you should consult a specialist.

Detralex contains 500 mg of micronized flavonoid fraction (Purified micronized flavonoid fraction), in which diosmin is 90% (450 mg), - 10% (50 mg).

Auxiliary components: gelatin, magnesium stearate, MCC, sodium carboxymethyl starch, talc, purified water. Composition of pos.: macrogol 6000, sodium lauryl sulfate, orange-pink premix for pos. (magnesium stearate, , hypromellose, iron dyes - yellow and red oxides, titanium dioxide).

Release form

Tablets p/pl. shell. In blisters of 15 pcs., package No. 30; No. 60.

In other countries, the manufacturing company may use the trade names Variton, Daflon 500, Venitol, Capiven, Ardium, Arvenum 500 for its product.

pharmachologic effect

Venoprotective and venous stabilizing. Pharmacological group: microcirculation correctors and angioprotectors in combinations .

Pharmacodynamics and pharmacokinetics

Possesses angioprotective And venotonic action, reduces venostasis , stretchability of veins and capillary permeability, increases the tone of the venous walls, improves microcirculation and lymphatic drainage. Increases the ability of capillaries to maintain the integrity of the walls under mechanical stress.

The use of the drug Detralex helps reduce interaction And endothelium , as well as adhesion leukocytes in postcapillary venules, which reduces the severity of the damaging effects of inflammatory mediators on the valves vein valves and venous walls .

T½ - 11 o'clock. Excretion of active components is carried out mainly through the intestines. About 14% of the dose taken is excreted by the kidneys.

Indications for use of Detralex

When are vein pills prescribed?

Indications for use of Detralex are organic and functional venolymphatic insufficiency of the lower extremities , which is manifested by swelling and pain, a feeling of heaviness in the legs, trophic disorders, and cramps.

When is the drug used as a pill for hemorrhoids?

The use of the drug Detralex is indicated for the symptomatic treatment of acute hemorrhoidal attack.

Additionally

Detralex tablets: instructions for use

Instructions for use of Detralex for varicose veins

At venolymphatic insufficiency recommended dose - 2 tablets. 500 g per day. The tablets are taken with meals, one in the daytime, the second in the evening.

The medicine is prescribed only to adult patients. To enhance the effect, the doctor may also recommend using external therapy - ointment or gel.

Duration of treatment with Detralex for varicose veins , as well as the need for repeated courses, is determined by the doctor.

Detralex for hemorrhoids. How long to take pills for hemorrhoids?

In the description included with the drug on how to take it when hemorrhoids Detralex, it is indicated that in the acute stage of the disease (with ) must be taken 6 tablets/day. during the first 4 days of treatment and 4 tablets/day. in the next 3 days. Take the medicine with meals, dividing the daily dose into 2-3 doses.

Treatment chronic hemorrhoids involves taking 4 tablets daily. They are taken with meals, 2 at each dose. After 7 days, you can reduce the dose by half and reduce the frequency of applications to 1 r./day.

How long to take the medicine depends on the degree of advanced disease and the effectiveness of therapy. On average, doctors chronic hemorrhoids It is recommended to take the tablets in courses lasting 2-3 months. In case of an acute attack, treatment is carried out in short courses lasting 7 days.

If symptoms persist longer than this time, the patient should be examined by a proctologist.

Reviews of Detralex with hemorrhoids mostly good. The main disadvantage of the drug, according to consumers, is its high price. However, given that Detralex is a drug with proven effectiveness (patients often notice an improvement in the situation after 2-3 days of taking the tablets), many people still prefer it over cheaper analogues.

Overdose

There are no reports of cases of overdose.

Interaction

Special studies regarding drug and other forms of drug interaction have not been conducted. However, given the extensive experience of post-registration use of Detralex, to date there are no statements about its adverse interaction with other drugs.

Terms of sale

Over the counter.

Storage conditions

The drug does not require special storage conditions. The tablets belong to the category of potent drugs (list B), so they should be kept out of the reach of children.

Best before date

special instructions

The use of tablets for acute hemorrhoidal attack cannot replace specific therapy and creates barriers to treatment for others proctological diseases .

If after a short time there is no rapid decrease in the severity of symptoms, the patient should be examined by a proctologist, and the doctor should reconsider the therapy.

For people with impaired venous circulation, to increase the effectiveness of the drug, it is recommended:

avoid standing for long periods of time and prolonged exposure to the sun;
adjust body weight and diet;
wear compression stockings to improve blood circulation;
hike.

Detralex analogues: what can replace the drug?

Level 4 ATX code matches:

Drugs similar to Detralex with a similar mechanism of action, but a different composition: , , , Venolek , , Rutin , , , Yuglanex , Phlebofa .

Substitutes based on Hesperidine + Diosmin: Venozol , .

The medicine and its analogues are used to treat functional and organic venous insufficiency , and also when hemorrhoids (both acute and chronic).

The price of Detralex analogues is from 60 rubles. The cheapest analogues of Detralex are the drugs Rutin and Ascorutin.

In Ukraine, if Detralex is not available in the pharmacy, they may offer to replace it with drugs Venorin , Venosmin , Juantal , Dioflan , , Nostalex .

What is better - Detralex or Phlebodia 600?

On forums, the drug is often compared with its analogues. And most often with the drug Phlebodia 600 . The basis of both products is diosmin. Its concentration in Phlebodia 600 - 600 mg/tab., in Detralex - 450 mg/tab., however, in the latter its effect is enhanced due to the presence of hesperidin (50 mg/tab.).

At varicose veins Phlebodia 600 drink 1 tablet/day, Detralex - 2 tablets/day, that is, the daily dose of diosmin in the first case is 600 mg, in the second - 900 mg.

If we compare the pharmaceutical effect of the drugs and the specifics of their use, there are practically no differences.

However, thanks to the use of a unique technology for processing the active substance in its production, Detralex is absorbed into the body faster and more completely than its analogue, while its concentration in the blood plasma reaches a maximum after three to four hours.

Which is better - Detralex or Antistax?

Antistax is a herbal medicine that is used for venous circulation disorders. The capsules are based on dried extract of red grape leaves with a high content isoquercetin And quercetin glucuronide — flavonoids, which help stabilize cell membranes, normalize vascular permeability, and reduce edema.

However, if the effectiveness of Detralex has been confirmed during clinical experiments, scientific confirmation of the effectiveness Antistaxa as of today no.

Another difference between the drugs is that Detralex is allowed to be used during pregnancy, but information regarding safety and effectiveness Antistaxa no for pregnant women.

According to experts, Antistax for vascular diseases it may be recommended more as a preventive measure and as an addition to the main treatment.

Thrombovazim or Detralex - which is better?

is an enzyme preparation with thrombolytic , cardioprotective And anti-inflammatory activity . Its active ingredient is a complex of proteinases produced by Bacillus subtilis.

The medicine is prescribed as part of complex therapy for chronic venous insufficiency . It is strictly contraindicated in , pregnancy and breastfeeding.

Considering that the drugs Detralex and Thrombovazim have different pharmacological effects, it is not correct to compare them. Especially if you take into account that doctors often recommend taking them in combination.

Which is better - Detralex or Venarus?

Venarus is a Russian analogue of the drug. If we compare which is better - Detralex or Venarus , then we can come to the conclusion that there is no fundamental difference between them.

The basis of both drugs are substances And hesperidin , the products differ only slightly in the composition of the auxiliary components. Operating principle Venarus the same as its analogue, and the drug is prescribed for the same thing that Detralex tablets are used for.

Annotations for drugs are distinguished by the fact that an additional contraindication for use Venarus the lactation period is indicated. In addition, the cheaper analogue of Detralex is characterized by lower bioavailability and is somewhat more likely to cause side effects than the drug produced by Les Laboratoires Servier.

For children

There are no data regarding the use of the drug in pediatric practice.

Alcohol compatibility

There is no categorical ban on drinking alcohol during treatment with Detralex. The active ingredients of the drug are flavonoids hesperidin And diosmin , which, according to Wikipedia, are plant pigments and powerful natural antioxidants, do not interact with other substances and have no significant side effects.

However, it should be taken into account that, by affecting the cardiovascular system, alcoholic drinks provoke an increase in blood pressure and dilation of blood vessels, and a sharp influx of blood causes an increase in its stagnation in places of accumulation.

Thus, alcohol reduces the effectiveness of therapy and contributes to the progression of the disease.

Detralex during pregnancy

Despite the fact that studies have not revealed the teratogenic properties of Detralex, it is used with caution during pregnancy.

Due to lack of information about the ability diosmina And hesperidin penetrate into breast milk during breastfeeding, the use of the product should be avoided.

Studies on rats have shown that the drug does not have reproductive toxicity.

Reviews of Detralex during pregnancy allow us to conclude that the drug really helps with problems with veins and hemorrhoids . With the use of tablets, pain in the legs disappears, the legs become less tired and do not swell (and if they swell, then not so much), development is inhibited varicose veins , disappear (or significantly reduce) hemorrhoids .

Detralex - official* instructions for use. Auxiliary substance for polishing tablets. Directions for use and doses

Instructions:

Clinical and pharmacological group

Release form, composition and packaging

pharmachologic effect

Pharmacokinetics

Dosage

Overdose

Drug interactions

Use during pregnancy and lactation

Side effects

Storage conditions and periods

Indications

Contraindications

special instructions

Conditions for dispensing from pharmacies

Registration numbers

Tradename

Dosage form

Compound

Description

PHARMACOLOGICAL PROPERTIES

Pharmacodynamics

Pharmacokinetics

Pharmacotherapeutic group

ATX code: C05CA53

INDICATIONS AND CONTRAINDICATIONS

Indications

Contraindications

METHOD OF APPLICATION AND DOSES

SIDE EFFECT

Side effects of the drug

Overdose

SPECIAL INSTRUCTIONS

Release form

Storage

Best before date

Vacation conditions

GENERAL INFORMATION

Tradename

Dosage form

Compound

Description

PHARMACOLOGICAL PROPERTIES

Pharmacodynamics

Pharmacokinetics

Pharmacotherapeutic group

ATX code: C05CA53

INDICATIONS AND CONTRAINDICATIONS

Indications

Contraindications

Pregnancy and lactation period

METHOD OF APPLICATION AND DOSES

SIDE EFFECT

Side effects of the drug

Overdose

Interaction with other drugs

SPECIAL INSTRUCTIONS

RELEASE FORM AND STORAGE CONDITIONS

Release form

Storage

Best before date

Vacation conditions

ADDITIONAL INFORMATION

Detralex®: effect

What does the drug treat and what does the drug help with?

How does it work and what does the drug do?

Pharmacotherapeutic group of the drug

GENERAL INFORMATION

Tradename

Dosage form

Compound

Description

PHARMACOLOGICAL PROPERTIES

Pharmacodynamics

Pharmacokinetics

Pharmacotherapeutic group

ATX code: C05CA53

INDICATIONS AND CONTRAINDICATIONS

Indications

Interaction of the drug Detralex with other drugs
means