Magic pills to improve memory. Nootropil for active brain function
Everyone who has ever thought about accelerating their own brain has heard of nootropil. Students, tired mothers and just busy people who are often exhausted at work are those among whom this drug especially popular. I, as a person who takes not only nootropil, but also other drugs, will tell you about all the pros and cons of nootropil. In addition to the points described in the instructions for use of nootropil, we will consider some nuances, knowledge about which was obtained experimentally.
Let's start with the fact that nootropil is only tradename. In real life active substance, accounting for almost 100% of the weight of the tablet - piracetam. Piracetam was discovered back in the 70s and was actively used by astronauts. With long-term use, the drug increased general tone body and helped to be more resistant to external pressure. Because side effects This nootropic drug is very weak, it was decided not to hide such a convenient thing from the people. Since then, piracetam has been sold in several forms: cheap small tablets and capsules of 200-400 mg; more expensive large tablets with a brand name. The cost of the first is about 30 rubles per 21 grams of the drug. But the second, produced in tablets of 800, 1200 and 2400 mg, costs a little more - up to 300 rubles per pack. However, this is more than enough for one cycle of administration.
Action of nootropil
Nootropil is one of the most harmless drugs that stimulate nervous system. Its action is based on increasing the maximum throughput of the body. So, the brain begins to consume more glucose, blood circulation accelerates. Thus, we increase the limit of the body in general and the brain in particular. By the way, the drug is allowed to be used by athletes. What is most likely important for students is that the brain does not lack energy when working hard. And this is good.
Since nootropil is the first of its group of drugs, the action of the others is also based on the processes described above. It is worth noting that the product does not begin to act instantly: you begin to feel the first effect at least a week after continuous use, and by the end of the second week the effect reaches its peak. As you might have guessed, all thanks to the “cumulative effect”. He, in turn, disappears soon after stopping taking the pills.
Let's talk about how long you should take this drug, as well as dosages. The instructions for use of nootropil warn that average dose should not exceed 2.6 grams per day. This is quite a lot for children, but for an adult who just wants to make his life a little easier - just right. Children are advised to limit themselves to 1-2 tablets of 800 mg in the morning and at lunch. But this is only for prevention. If you need a certain acceleration or treatment is prescribed, then the dosages will be slightly higher. Here's a table for you.
Do not forget that in this table the number of tablets is indicated with the expectation that you will use the smallest ones (800 mg each). Naturally, if you take a bunch of piracetam in 400-milligram capsules, you will have to drink more and, accordingly, if you buy large tablets, their quantity will be completely different. The instructions for using nootropil take into account the fact that some will want to use the tablets longer. This cannot be done. The maximum duration of use should be limited to two, maximum three weeks, after which a month (or more) break should be taken.
Side effects of nootropil
Nootropil in capsules is much less common. It’s easier to buy piracetam - it’s three times cheaper, and the capsules are also 400 mg. Despite the fact that in all publications the remedy is described as sedative, in fact this is not entirely true. When taking nootropics, irritability and general anxiety can significantly increase. In terms of physiology, you can observe nausea, headaches, and convulsions. Upon acceptance large doses Personally, I noticed mild angina, which is stated directly in the instructions. If you have heart problems, be careful.
But don't be alarmed. Everything is not as scary as it might seem. After all, we must also take into account the fact that some people are simply not inclined to accept similar drugs, so even harmless 1.6 grams per day can make you feel bad. These cases are also included in the general statistics, which significantly increases “ average temperature around the hospital." However, even if you find yourself in that small percentage of special people, there is no cause for concern: with a small dosage, the maximum that can be is bad feeling. If you notice that something is going wrong, just stop taking the pills and that's it. Increased side effects are not observed immediately, so by stopping taking nootropil in time, you will protect yourself with small losses.
A separate conversation with those who suffer from kidney disease. The instructions for use of Nootropil prohibit such people from drinking, since it is excreted exclusively through the kidneys, and similar doses are given to them heavy load. In this regard, it is strongly recommended to consult a doctor, or better yet, to abandon the idea of taking nootropics altogether. In general, do not forget to check the list of contraindications with your doctor. Pregnant women, for example, are also prohibited from using it. But it is sometimes used in the treatment of infants. So there are times when you can’t figure it out on your own.
“Instructions” from a nootropil lover
As I promised, I will tell you about this nootropic from my own lips. Since this is not the only drug from this series, I have something to compare with. In general, nootropil can be useful if you drink it correctly, get enough sleep and don’t sit at the computer all day. The fact that such products should be used exclusively before 3 pm is widely known fact, and I advise you to follow this rule. If you decide to take 1.6 grams per day, take one tablet in the morning and one at lunch. If you drink them closer to the night, insomnia may begin. On the one hand, this is good, since there is no such thing as too much time, but you won’t be able to do anything useful during this time. The efficiency will be low. Therefore, I advise you to take doses in the evening only at extreme cases and only when you have taken the drug for at least a week.
Another point that the instructions for using nootropil do not mention is changing the dosage. If you take 5 grams of piracetam a day for 3 weeks or more, your kidneys will give up before your brain. I recommend starting with 1.6 grams per day and increasing the dose to 3 grams by the tenth day. And then start taking five at a time, if you want. On initial stage It seemed to me that it doesn’t matter whether you took 3 grams of tablets or more - you won’t notice the effect. But after some time, the dependence of your activity on the dosage of the tablets will be more noticeable.
For people who want to stay awake at night, I advise you to stretch out the intake of nootropil. The first appointment is at lunch, the second is at 4-5 pm, and the third is closer to 9 am. Complementing this regular coffee you can easily stay productive until 4 pm. In this case, you will need to sleep no more than 6 hours, since all nootropics, without exception, reduce the need for sleep. By at least, with repeated doses. Naturally this complete violation instructions for use, so I do not take any responsibility if you start doing this.
Finally, I’ll give you a few numbers and logically fit them into our material. The fact is that the instructions for using nootropil indicate 4-6 weeks as a treatment time. In this case, the dosage of the drug taken can reach 10 grams. You must understand that such actions and quantities of the drug are due to the fact that everything happens under the supervision of a doctor. And you won’t compare yourself with people who received severe injury brain Do not try to take the drug in such large quantities. 5 grams per day is the maximum that you can afford without worrying about the disastrous consequences.
In this article you can find instructions for use medicinal product Nootropil.
Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Nootropil in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogs of Nootropil if available structural analogues. Used to treat the consequences of stroke and brain disorders in adults, children, as well as during pregnancy and breastfeeding.
Nootropil - nootropic drug, cyclic derivative gamma-aminobutyric acid(GABA).
Directly affects the central nervous system, improving cognitive (cognitive) processes, such as learning ability, memory, attention, as well as mental performance. Nootropil has an effect on the central nervous system in various ways: changes the speed of spread of excitation in the brain, improves metabolic processes in nerve cells, improves microcirculation, affecting the rheological characteristics of the blood and without causing a vasodilator effect.
Improves connections between the cerebral hemispheres and synaptic conduction in neocortical structures, increases mental performance, and improves cerebral blood flow.
Piracetam ( active substance drug Nootropil) inhibits platelet aggregation and restores the elasticity of the erythrocyte membrane, reduces the adhesion of erythrocytes. At a dose of 9.6 g, it reduces the level of fibrinogen and von Willebrand factors by 30-40% and prolongs bleeding time. Piracetam has a protective and restorative effect in cases of impaired brain function due to hypoxia and intoxication.
Nootropil reduces the severity and duration of vestibular nystagmus.
Piracetam + excipients.
After taking the drug orally, Nootropil is quickly and almost completely absorbed from the gastrointestinal tract. The bioavailability of the drug is approximately 100%. Does not bind to blood plasma proteins. In animal studies, piracetam selectively accumulates in the tissues of the cerebral cortex, mainly in the frontal, parietal and occipital lobes, in the cerebellum and basal ganglia. Not metabolized in the body. Penetrates the blood-brain and placental barrier.% of piracetam is excreted unchanged by the kidneys by renal filtration.
- symptomatic treatment of psychoorganic syndrome, in particular in elderly patients with memory loss, dizziness, decreased concentration and general activity, mood changes, behavioral disorders, gait disturbance, as well as in patients with Alzheimer's disease and senile dementia of the Alzheimer's type;
- treatment of consequences ischemic stroke such as speech disorders, disorders emotional sphere, to increase motor and mental activity;
- chronic alcoholism - for the treatment of psychoorganic and withdrawal syndromes;
- comatose states (and during the recovery period), incl. after brain injuries and intoxications;
- treatment of dizziness of vascular origin;
- as part of complex therapy low learning ability in children with psychoorganic syndrome;
- for the treatment of cortical myoclonus as mono- or complex therapy;
- sickle cell anemia (as part of complex therapy).
Film-coated tablets 800 mg and 1200 mg.
Oral solution 200 mg/ml.
Solution for intravenous and intramuscular injection(injections in injection ampoules).
Instructions for use and dosage
Prescribed orally and parenterally. Daily dose mg/kg.
Parenterally prescribed in case of impossibility of oral administration, in the same daily dose.
Inside taken during a meal or on an empty stomach; tablets and capsules should be taken with liquid (water, juice). Multiplicity of reception times per day.
At symptomatic treatment chronic psychoorganic syndrome, depending on the severity of symptoms, 1.2-2.4 g per day is prescribed, and during the first week - 4.8 g per day.
In the treatment of the consequences of a stroke ( chronic stage) is prescribed 4.8 g per day.
During treatment comatose states, as well as difficulties in perception in persons with brain injuries, the initial dose is 9-12 g per day, maintenance - 2.4 g per day. Treatment continues for at least 3 weeks.
With alcoholic withdrawal syndrome- 12 g per day. Maintenance dose 2.4 g per day.
Treatment of dizziness and related balance disorders - 2.4-4.8 g per day.
To correct learning disabilities, children are prescribed 3.3 g per day - 8 ml of a 20% solution for oral administration 2 times a day. Treatment continues throughout the school year.
For cortical myoclonus, treatment begins with 7.2 g per day, every 3-4 days the dose is increased by 4.8 g per day until maximum dose 24 g per day. Treatment continues throughout the entire period of the disease. Every 6 months, attempts are made to reduce the dose or discontinue the drug, gradually reducing the dose by 1.2 g every 2 days. With no effect or little therapeutic effect treatment is stopped.
For sickle cell anemia, the daily prophylactic dose is 160 mg / kg of body weight, divided into 4 equal doses.
- nervousness;
- drowsiness;
- depression;
- dizziness;
- headache;
- imbalance;
- insomnia;
- excitation;
- anxiety;
- hallucinations;
- increased sexuality;
- weight gain (more often occurs in elderly patients receiving the drug in doses of more than 2.4 g per day);
- nausea, vomiting;
- diarrhea;
- stomach ache;
- dermatitis;
- rashes;
- edema;
- asthenia.
- acute disorder cerebral circulation(hemorrhagic stroke);
- terminal stage renal failure(with CC<20 мл/мин);
- children's age up to 1 year (for oral solution);
- children's age up to 3 years (for tablets and capsules);
- hypersensitivity to the components of the drug.
Use during pregnancy and breastfeeding
Adequate and strictly controlled studies of the safety of Nootropil during pregnancy have not been conducted. The drug should not be prescribed during pregnancy unless absolutely necessary.
Piracetam penetrates the placental barrier and is excreted in breast milk. The concentration of piracetam in newborns reaches 70-90% of its concentration in the mother’s blood. If it is necessary to use the drug during lactation, you should refrain from breastfeeding.
Experimental studies on animals did not reveal any damaging effects on the embryo and its development, incl. in the postnatal period, as well as changes in the course of pregnancy and childbirth.
Contraindicated in children under 1 year of age in the form of an oral solution and in children under 3 years of age in the form of tablets and capsules.
Due to the effect of piracetam on platelet aggregation, it is recommended to prescribe the drug with caution to patients with impaired hemostasis, during major surgical operations or to patients with symptoms of severe bleeding. When treating patients with cortical myoclonus, abrupt interruption of treatment should be avoided, which may cause resumption of attacks.
During long-term therapy in elderly patients, regular monitoring of renal function parameters is recommended; if necessary, dose adjustment is carried out depending on the results of a creatinine clearance study.
Impact on the ability to drive vehicles and operate machinery
Taking into account possible side effects, caution should be exercised when operating machinery or driving a vehicle.
There was no interaction of Nootropil with clonazepam, phenytoin, phenobarbital, or sodium valproate.
Piracetam in high doses (9.6 g per day) increased the effectiveness of acenocoumarol in patients with venous thrombosis: there was a greater decrease in platelet aggregation, fibrinogen levels, von Willebrand factors, blood and plasma viscosity than when acenocoumarol was prescribed alone.
The possibility of changing the pharmacodynamics of piracetam under the influence of other drugs is low, because 90% of its dose is excreted unchanged in the urine.
When taking piracetam at a dose of 20 mg per day, Cmax in the blood plasma and the nature of the pharmacokinetic curve of anticonvulsants (carbamazepine, phenytoin, phenobarbital, valproic acid) in patients with epilepsy receiving constant doses of these drugs do not change.
When taking Nootropil at a dose of 1.6 g with alcohol, the serum concentrations of piracetam and ethanol (alcohol) did not change. Used to treat alcohol withdrawal syndrome.
Analogues of the drug Nootropil
Structural analogues of the active substance:
News edited by: admin017, 18:28
How long to take nootropil
Nootropil. I decided to drink before the exams. how to take it right? I have 800 and 1200 mg tablets
If you are in a hurry to evenly divide half the tablet into three more parts, then good. But in general, this is a bit complicated - even parts are unlikely to be obtained from this half.
Nootropil is taken as follows (standard regimen for improving memory and the condition of brain vessels): 1 tablet. 3 times a day for a month. Then a break and a month later another course.
The most common side effects are: increased appetite, drowsiness.
But! The effect after 3-4 weeks is excellent - memory really improves and mood too.
The only thing is that for young people, such as students, this may not be particularly noticeable. But for pensioners (in fact, the drug was originally designed for older people whose blood vessels are already bad and need to be brought into working condition) it works extremely well.
Therefore, students should start taking things like nootropil a month before the session.
Throw away the 1200 tablets immediately! This is a very high dose!
The standard dosage is 800.
For weakened people and children (and this happens.) - 400.
In what cases is the drug “Nootropil” taken: reviews and instructions for use
If there is a need to improve cognitive mental processes, which include the state of memory, the ability to assimilate new information and analysis, attention and the ability to concentrate, then in such cases the drug Nootropil is prescribed. Reviews about it and instructions for use will be provided to readers in this article.
How does Nootropil work?
This well-proven remedy has a beneficial effect on the state of the central nervous system in different ways. Piracetam, which is the main active ingredient of the drug, stabilizes metabolic processes in cells, increases the rate of transmission of excitation in nerve tissues, improves microcirculation (without causing vasodilation), and in the case of brain damage, provoked, in particular, by hypoxia or intoxication, has protective action. In addition, the drug has a beneficial effect on the connection between the hemispheres and, by improving cerebral blood flow, enhances mental performance.
Features of the drug
It is important that, judging by numerous reviews, this drug does not have a sedative or psychostimulating effect on the patient’s nervous system. It is also important to know that the effect of the drug “Nootropil”, reviews of which you can read in this article, does not occur instantly. The first results can be noticed only seven days after starting regular use of the medicine, and after fourteen days they will reach their maximum. As you probably understand, this feature is associated with the cumulative effect that the drug has. True, it disappears after the end of the reception.
In what cases is the drug "Nootropil" used?
Nootropil tablets and injections are a very popular remedy used by doctors for many pathologies. And, judging by the reviews of specialists and patients, this treatment has good results.
- The drug is used in cases of psychoorganic syndrome, which is characteristic mainly of older people and manifests itself in the form of memory loss, dizziness, problems concentrating, decreased general activity, behavioral disorders, coordination and gait disorders;
- it is also prescribed as part of complex treatment for Alzheimer's disease;
- with its help, the consequences of ischemic stroke are eliminated, expressed in speech and emotional disorders, it is also used to increase the mental and motor activity of the patient;
- this remedy is used in the treatment of chronic alcoholism and coma caused by intoxication or brain injury (during the recovery period);
- as part of complex therapy, the drug "Nootropil" is administered for cortical myoclonus, low learning ability of children (including oligophrenia and cerebral palsy), as well as in cases of sickle cell anemia.
The drug "Nootropil": instructions
Reviews about the drug prove that in order to achieve the maximum effect from its use, it is necessary to follow the dosage prescribed by the doctor and take it systematically, and not from case to case. The described remedy is prescribed in the form of injections or tablets. The daily dose should not exceed 160 mg per kilogram of human weight. The minimum amount is 30 mg/kg. Inside, the remedy is taken two to four times a day with food or on an empty stomach and washed down with water or juice.
Dosage for different types of diseases
- In the treatment of symptoms of a chronic psychoorganic syndrome, it is prescribed (depending on the patient's condition) from 1.2 to 2.4 g of the drug per day. In the first week of administration, the dose is 4.8 g.
- Consequences of stroke - 4.8 g per day.
- Coma - 9-12 g per day (initial dose) and 2.4 g per day (maintenance).
- Withdrawal syndrome in alcoholism – 12 g per day. Maintenance therapy – 2.4 g.
The drug "Nootropil" for children
Reviews of experts claim that the "Nootropil" remedy is very effective in cases where the child does not do well at school, cannot concentrate and poorly remembers the material read. It is also prescribed for children suffering from cerebral palsy, children with the consequences of birth trauma or developmental disorders in the prenatal period. This drug is also useful for patients with oligophrenia, and for patients with speech problems (alalia, anarthria, stuttering, delayed speech development, etc.). The drug is not prescribed to babies under one year of age.
Dosage of the drug for children of different ages
On average, a child is prescribed the described drug at the rate of 30 to 50 mg per kilogram of body weight per day. This takes into account that:
- up to five years, the dose is from 0.6 to 0.8 g per day;
- from five to sixteen - from 1.2 to 1.8 g;
- with poor performance, no more than 3.3 g per day is prescribed (this corresponds to eight milliliters of a 20% solution of the drug);
- cortical myoclonus requires a dose of 7.2 g per day (the amount of the drug is increased every other day by 4.5 g).
Are there any side effects from using the drug?
Judging by the statement of experts, the Nootropil remedy, which you can read about here, is well tolerated and basically does not cause side effects. But in some cases, most often associated with an incorrect dosage of the drug (more than 5 g per day), the following manifestations may be observed: nervousness, motor disinhibition, depression, drowsiness, dizziness and headache. Possible imbalances, insomnia, anxiety, increased libido, tremors and weight gain are also possible.
Contraindications
Do not prescribe the drug for psychomotor agitation and acute cerebrovascular accident. It can also be dangerous in case of kidney failure. This drug is contraindicated during pregnancy, and breastfeeding should be discontinued during lactation. Extreme caution should also be observed in patients with severe bleeding and major surgical interventions. Patients with epilepsy should take the medicine with caution, as it may cause an exacerbation of the disease. Remember that intolerance to the components of this drug leads to the development of allergic reactions.
special instructions
When taking the drug "Nootropil", reviews of which are provided to your attention, do not forget that elderly patients require regular monitoring of the condition of their kidneys, and patients with liver problems need monitoring of the functioning of this organ. Treatment of cortical myoclonus with this drug cannot be abruptly interrupted, as this may provoke a resumption of attacks. If the patient has sleep disturbances, the last dose of medication should be no later than three o'clock in the afternoon. It is also important for patients who drive a car or engage in activities that require concentration to exercise caution.
Signs of overdose
You are probably already convinced that Nootropil tablets and syrups require medical supervision over the course of the treatment process and, like other dosage forms, do not tolerate “amateur activity”. An overdose of these drugs is manifested by abdominal pain, nausea and vomiting, as well as diarrhea mixed with blood. If such signs are present, it is necessary to induce vomiting and rinse the stomach, followed by symptomatic therapy. Be healthy!
Nootropil - instructions for use
Everyone who has ever thought about accelerating their own brain has heard of nootropil. Students, tired mothers and simply busy people who are often exhausted at work are those among whom this drug is especially popular. I, as a person who takes not only nootropil, but also other drugs, will tell you about all the pros and cons of nootropil. In addition to the points described in the instructions for use of nootropil, we will consider some nuances, knowledge about which was obtained experimentally.
Let's start with the fact that nootropil is just a trade name. In real life, the active substance, which makes up almost 100% of the weight of the tablet, is piracetam. Piracetam was discovered back in the 70s and was actively used by astronauts. With prolonged use, the drug increased the overall tone of the body and helped to be more resistant to external pressure. Since the side effects of this nootropic drug are very weak, it was decided not to hide such a convenient thing from the people. Since then, piracetam has been sold in several forms: cheap small pills and pomg capsules; more expensive large tablets with a brand name. The cost of the first is about 30 rubles per 21 grams of the drug. But the second, produced in tablets of 800, 1200 and 2400 mg, costs a little more - up to 300 rubles per pack. However, this is more than enough for one cycle of administration.
Action of nootropil
Nootropil is one of the most harmless drugs that stimulate the nervous system. Its action is based on increasing the maximum throughput of the body. So, the brain begins to consume more glucose, blood circulation accelerates. Thus, we increase the limit of the body in general and the brain in particular. By the way, the drug is allowed to be used by athletes. What is most likely important for students is that the brain does not lack energy when working hard. And this is good.
Since nootropil is the first of its group of drugs, the action of the others is also based on the processes described above. It is worth noting that the product does not begin to act instantly: you begin to feel the first effect at least a week after continuous use, and by the end of the second week the effect reaches its peak. As you might have guessed, all thanks to the “cumulative effect”. He, in turn, disappears soon after stopping taking the pills.
Let's talk about how long you should take this drug, as well as dosages. Instructions for use nootropil warns that the average dose should not exceed 2.6 grams per day. This is quite a lot for children, but for an adult who just wants to make his life a little easier - just right. Children are advised to limit themselves to 1-2 tablets of 800 mg in the morning and at lunch. But this is only for prevention. If you need a certain acceleration or treatment is prescribed, then the dosages will be slightly higher. Here's a table for you.
Do not forget that in this table the number of tablets is indicated with the expectation that you will use the smallest ones (800 mg each). Naturally, if you collect a bunch of piracetam in 400-milligram capsules, you will have to drink more and, accordingly, if you buy large tablets, their number will be completely different. The instructions for using nootropil take into account the fact that some will want to use the tablets longer. This cannot be done. The maximum duration of admission should be limited to two, maximum - three weeks, after which a month (or more) break should be taken.
Side effects of nootropil
Nootropil in capsules is much less common. It’s easier to buy piracetam already - it’s three times cheaper, and capsules are also 400 mg each.
But don't be alarmed. Everything is not as scary as it might seem. After all, we must also take into account the fact that some people are simply not inclined to take such drugs, so even a harmless 1.6 grams per day can make you feel bad. These cases are also included in the general statistics, which significantly increases the “average temperature in the hospital.” However, even if you find yourself in that small percentage of special people, there is no reason to worry: with a small dosage, the maximum that can happen is poor health. If you notice that something is going wrong, just stop taking the pills and that's it. Increased side effects are not observed immediately, so by stopping taking nootropil in time, you will protect yourself with small losses.
A separate conversation with those who suffer from kidney disease. The instructions for use of Nootropil prohibit such people from drinking, since it is excreted exclusively through the kidneys, and such doses create a large burden on them. In this regard, it is strongly recommended to consult a doctor, or better yet, abandon the idea of taking nootropics altogether. In general, do not forget to check the list of contraindications with your doctor. Pregnant women, for example, are also prohibited from using it. But it is sometimes used in the treatment of infants. So there are times when you can’t figure it out on your own.
“Instructions” from a nootropil lover
As I promised, I will tell you about this nootropic from my own lips. Since this is not the only drug from this series, I have something to compare with. In general, nootropil can be useful if you drink it correctly, get enough sleep and don’t sit at the computer all day. The fact that such products should be used exclusively before 3 o'clock in the afternoon is a widely known fact, and I advise you to follow this rule. If you decide to take 1.6 grams per day, take one tablet in the morning and one at lunch. If you drink them closer to the night, insomnia may begin. On the one hand, this is good, since there is no such thing as too much time, but you won’t be able to do anything useful during this time. The efficiency will be low. Therefore, I advise you to take doses in the evening only in extreme cases and only when you have taken the drug for at least a week.
Another point that the instructions for using nootropil do not mention is changing the dosage. If you take 5 grams of piracetam a day for 3 weeks or more, your kidneys will give up before your brain. I recommend starting with 1.6 grams per day and increasing the dose to 3 grams by the tenth day. And then start taking five at a time, if you want. At the initial stage, it seemed to me, it doesn’t matter whether you took 3 grams of tablets or more - you won’t notice the effect. But after some time, the dependence of your activity on the dosage of the tablets will be more noticeable.
For people who want to stay awake at night, I advise you to stretch out the intake of nootropil. The first appointment - at lunchtime, the second - at 4-5 pm, and the third - closer to 9 o'clock. By supplementing this with regular coffee, you can easily stay productive until 4 pm. In this case, you will need to sleep no more than 6 hours, since all nootropics, without exception, reduce the need for sleep. At least with repeated use. Naturally, this is a complete violation of the instructions for use, so I do not bear any responsibility if you start doing this.
Finally, I’ll give you a few numbers and logically fit them into our material. The fact is that the instructions for using nootropil indicate 4-6 weeks as a treatment time. In this case, the dosage of the drug taken can reach 10 grams. You must understand that such actions and quantities of the drug are due to the fact that everything happens under the supervision of a doctor. And you won’t compare yourself to people who have suffered severe brain injury. Do not try to take the drug in such large quantities. 5 grams per day is the maximum that you can afford without worrying about the disastrous consequences.
Good day everyone! In my experience, the article lists some horse doses. My experience of taking Nootropil is about 15 years. Effects: speed of thinking and speech increases, sociability increases, eyes sparkle attractively... (And I’m a phlegmatic person, slow and shy). At first, for several years, she took 400 mg per day in the morning 1 time. Now for more than a year I have been taking Nootropil syrup (which is 200 mg/1 ml) 1.5 ml (i.e. 300 mg) once in the morning, it’s enough (I’m 41 years old, weight 55 kg). While taking Nootropil, you need to consume a large amount of liquid (I read it on some medical website), and this is true. If I forget to drink, by the evening I feel exhausted and tired... I looked here in search of an answer: is it possible to take Nootropil constantly, without interruption?
Within a couple of months, a feeling of mega-brain arises.
I am taking the drug for the second time. Last year, spring and autumn, 2 packs per course. And now it’s the same. My head is clearer, my memory is excellent. I sleep without problems all night. I'm learning a foreign language. Helps a lot. For this reason, in fact, I take the drug.
I'm on my third pack and my memory hasn't improved at all.
Mom took betaserc before, the dizziness temporarily stopped, after which dizziness was noted again, the doctor prescribed nootropil 1200 mg twice a day, is the doctor’s prescription correct?
nootronic, I know that it is necessary to take a course through one, but I don’t know about others
What are the dosages when taking nootropil in solution? In ml? (instruction attached in d)
Oh, why did you put 2 tablets each, half a tablet from a 1200g pack is enough for me to stay awake all night and walk around in the morning irritated, but quite active. And this is if I drink half before one in the afternoon. And if it is a whole, then you can immediately say goodbye to sleep
Tell us more about the drug, did it help you
Thank you very much for the information! The question is, what are the maximum effects? Are there any effects on intelligence?
NOOTROPIL how often can I take these capsules - and what is the best dosage? 800 or more ml!! ? and in general what does it give us
symptomatic treatment of psychoorganic syndrome, in particular in elderly patients, accompanied by memory loss, dizziness, decreased concentration and decreased general activity, mood changes, behavioral disorders, gait disturbance, as well as in patients with Alzheimer's disease and senile dementia of the Alzheimer's type;
treatment of the consequences of ischemic stroke, such as speech impairment, emotional disturbance, decreased motor and mental activity;
and diseases. You need to drink 1 capsule in the morning and after lunch. In the evening
You can’t drink it - it disturbs sleep and excites the brain.
By itself, blood circulation does not improve.
Dosage from 200 mg to 1200 mg per day. May cause insomnia if taken in the evening.
Until what time can you take nootropil?
Nootropil was prescribed to be taken 3 times a day, but the instructions do not say anything about use in the evening, after six. Can it be taken with dinner? Or until what time do you have time: before 16-00, before 18-00?
In general, it is undesirable to take it in the evening. The last dose should be an hour in three to four days. Otherwise, it will be difficult to fall asleep at night. Since it has a stimulating effect on the psyche. In general, its action can be individual. That is, observe how you feel and how you can fall asleep after it. You can cut the third dose in half. For example, take two capsules in the morning and afternoon, and one capsule the third time. Or switch to two doses a day.
Well, in general, I saw in one annotation such a phrase that the last single dose should be taken no later than five in the evening to prevent sleep disturbances (this is about piracetam, but if you are not lazy and look at the active ingredient of the medicine called nootropil, then this is exactly name and behold! ;). But in different cases the drug is prescribed to be taken two or four times a day. I attributed the last appointments to eight or nine in the evening and... nothing, I slept like the dead, there were no problems, it’s not coffee. So if you are very concerned about this topic, read the instructions for piracetam too, if not, take it as it is, nothing extraordinary will happen to you.
Nootropil is used to improve memory and the condition of blood vessels in the brain: 1 tablet. 3 times a day for a month. Take the drug up to 18 hours. A month break, and then the course again.
An excellent effect occurs after 3-4 months - memory and mood improve too.
For pensioners (in fact, the drug was originally designed for older people whose blood vessels are already bad and need to be brought into working condition) it works extremely well.
Students should start taking things like nootropil a month before the session.
This drug, like its domestic analogue Piracetam, is not recommended to be taken after 18 pm due to its tonic effect on the body and possible sleep disturbance due to this property of the drug.
Nootropil for active brain function
Nootropil belongs to the group of nootropics. The main active ingredient is Piracetam. Recommendations on how to take Nootropil are individual in each specific case. The effect of the drug is to accelerate and enhance mental activity by optimizing the functioning of neurons. In addition, the drug affects the speed of impulse transmission.
The drug promotes the activation of life-support metabolic reactions in neurons by improving blood flow in them, and, consequently, improving the delivery of oxygen, glucose and many necessary substances. Microcirculation is normalized by reducing blood viscosity, thinning it, improving the functioning of red blood cells, and their ability to change their shape due to the elasticity of the membranes.
- Severe degrees of impairment of consciousness (coma).
- Psychoorganic disorders. Including pathological changes in memory in the elderly, impaired ability to concentrate, pathological changes in behavior.
- Therapy after strokes.
- Therapy for emotional disorders.
- Alzheimer's disease.
- To alleviate the symptoms of withdrawal syndrome in the treatment of alcohol dependence.
- With a decrease in learning ability in children with psychoorganic disorders.
Release form and method of application
The drug is available in the form of tablets (800 mg), capsules (400 mg), solution for intravenous administration 20% (125 ml), injections 20% (5 ml). How to take Nootropil? Capsules and tablets are taken before or during meals. Drink with water. For adults: 30 - 160 mg/kg body weight per day. The dose is divided into 2-4 doses.
If the doctor has not given other recommendations on how to take Nootropil to improve memory, then for psychoorganic causes of such disorders it is recommended to take 4.8 g / day. The average course of this dosage is a week. Maintenance 1.2-2.4 g/day.
Treatment of post-ischemic cerebral changes: 4.8 g/day.
Severe disturbances of consciousness (coma): start with 9-12 g/day, then move to the maintained figures - 2.4 g/day. The course is about 21 days.
Dizziness, loss of coordination and balance: 2.4-4.8 g/day.
With a decrease in learning ability: 3.3 g/day. Admission may continue throughout the academic year.
In the treatment of alcohol dependence: in the acute period of abstinence when stopping alcohol, 12 g/day, then 2.4 g/day. If the patient cannot take Nootropil orally, the method of administration can be changed to intravenous.
It can also be prescribed for liver and kidney failure. How much Nootropil to take for kidney pathologies depends on creatinine clearance and is selected individually by the attending physician. For liver pathologies, no dose adjustment is required. In case of liver failure, dosages are adjusted taking into account creatine clearance indicators.
Side effects and contraindications
Side effects of Nootropil are extremely rare. Possible: nervousness, deterioration of the emotional background, slight drowsiness. Complications occur with prolonged use of the drug. Side effects of Nootropil also include headaches, dizziness, sleep disturbances, increased libido, hallucinations, anxiety, nausea, stool problems, and allergic reactions due to intolerance to Piracetam.
- The use of the drug is contraindicated in case of insufficiency of renal function with creatinine clearance below 20 ml/min, in children under one year of age, in case of hemorrhagic stroke, intolerance to Piracetam, Pyrrolidone.
- Pregnancy and lactation. There is no reliable data proving the safety of using the drug in pregnant women; no studies have been conducted. The main active ingredient has the ability to penetrate both the placenta and the milk of a nursing mother. When taking Nootropil, 70-90% of its volume determined in the mother’s blood is determined in the baby. Therefore, it is practically not prescribed to pregnant women. Only in cases of vital importance. Breastfeeding women are advised to stop breastfeeding while using the drug.
The use of the drug in parallel with alcohol consumption does not change the concentration in the blood of either one or the other. The drug is used with caution in case of changes in the blood coagulation system, significant bleeding, or during planned operations. With long-term use of the drug, it is recommended to monitor laboratory renal parameters. It is not recommended to use Piracetam for activities that require quick reactions, such as driving a car.
No specific symptoms of overdose have been identified. Possible intoxication symptoms: nausea, vomiting, abdominal pain, upset stool, possible diarrhea with blood. In such cases, gastric lavage, stimulation of vomiting, and hemodialysis are performed.
Nootropil is a drug prescribed by doctors to stimulate mental abilities. It is prescribed for patients with various cognitive impairments: memory loss, brain dysfunction and other disorders. It goes on sale in the form of tablets, capsules and dosage forms intended for injections.
Composition and principle of action
The active component of Nootropil is piracetam. This is a nootropic substance that directly affects the brain functions responsible for assimilation and processing of new information. Strengthens mental abilities, stimulates memory and concentration on any object or subject, increases a person’s ability to learn.
Reaching the lesion, the drug has a number of therapeutic effects:
- has a beneficial effect on the central nervous system (CNS). Accelerates and spreads excitation in the brain, stimulates blood microcirculation, increases metabolism in nerve cells. Changes blood viscosity without affecting blood vessels;
- improves blood flow and communication between the hemispheres, thereby effectively increasing the patient’s mental abilities;
- has a positive effect on the most important components: platelets and red blood cells. Prevents excessive blood clotting and makes bleeding time longer.
The drug prevents involuntary trembling of the pupils (vestibular nystagmus). Nootropil is often prescribed to people who have suffered severe intoxication and hypoxia (lack of oxygen). The drug protects the brain from unpleasant consequences and helps it recover.
Indications for use
The drug is prescribed by doctors for various disorders in which the brain cannot work at full capacity and properly process the information it receives. Such diseases include:
- psychoorganic syndrome. This includes symptoms that are the result of organic brain damage. Most often, it affects elderly patients whose memory is impaired, their concentration suffers, and their gait and speech are changed for the worse;
- withdrawal and psychoorganic syndrome, which is observed in patients suffering from chronic alcoholism;
- dementia and Alzheimer's disease;
- consequences of ischemic stroke: decrease in motor activity and psychomotor reactions, speech impairment and emotional background;
- frequent dizziness and difficulty maintaining balance;
- conditions characterized by the least degree of vigor and the patient’s inability to respond to external stimuli;
- sickle cell anemia (in combination with other drugs);
- myoclonus (involuntary contractions of one muscle or several groups at once that are uncontrollable). Can be used as a single drug or in combination with other drugs with similar effects.
Nootropil is often prescribed for children who have difficulty learning and lag behind other students. When used correctly, the drug gives a noticeable effect and helps to cope with organic brain disorders in such children.
Contraindications for use
Nootropil is a drug that has a powerful nootropic effect. When administered intravenously or intramuscularly, contraindications are minimized, but some restrictions are still present. These include: individual intolerance to the main or active components, severe renal impairment, hemorrhagic stroke and age under 1 year.
Nootropil injections: instructions for use
The drug is administered into the patient's body intramuscularly or intravenously. This method of administration is prescribed only if the use of other forms is impossible: if the patient is unconscious or has difficulty swallowing. Most often, doctors prescribe intravenous administration of Nootropil.
Before parenteral administration, the drug is diluted with a solution of dextrose (5-20%), Ringer or Mannitol (20%), fructose (5-20%), sodium chloride (0.9%), dextran 40 (10%). After this, the drug is introduced into the patient’s body using a special catheter at a constant speed. This is done 24 hours a day. The dose is determined individually depending on the patient’s condition and the clinical course of the disease.
Bolus (quick, almost instantaneous administration of the drug) is done within 2 minutes. The daily dose is divided into 2-4 procedures, the intervals between injections should be uniform, and the dosage per injection should not exceed 3 grams of Nootropil.
If the patient is overexcited, a bolus injection and Nootropil administration is carried out through the muscles. In children, elderly patients and patients with low body weight, the dosage is adjusted (taking into account age and weight). An additional disadvantage of intramuscular administration is pain. One should also take into account the fact that the dose should not exceed 5 ml. As soon as the possibility of oral administration appears, it is recommended to immediately switch to this method of treatment.
Use during pregnancy and breastfeeding
Piracetam is able to cross the barrier separating the lymph of the fetus and the expectant mother. Also, the drug can get into the milk, which is produced by the mammary gland during lactation. During pregnancy, it is better to replace Nootropil with another drug, and during the period of feeding a child, interrupt lactation for the duration of treatment.
Side effects
Uncontrolled use of Nootropil can lead to various side effects. Elderly patients who have received more than 2.5 grams of the drug per day may experience the following disorders: hyperkinesia (a state of increased agitation), nervousness, depression and apathy, drowsiness, general weakness and fatigue. Patients of different ages experience:
- imbalance, dizziness and headache;
- impaired motor skills and muscle weakness, in which muscles work involuntarily and chaotically;
- exacerbation of epilepsy;
- increased sexuality and psycho-emotional arousal;
- confusion and increased anxiety.
- insomnia, confusion, agitation, increased anxiety and frequent hallucinations;
- Gastrointestinal disorders: nausea, pain in the stomach, loose and frequent stools, vomiting.
Some patients experience sudden weight gain. If the components are intolerant, patients experience allergic reactions: skin rashes that look like nettle burns, swelling, redness of the skin and severe itching.
Signs of overdose
Gastrointestinal disorders were detected once. Doctors observed loose stool streaked with blood and painful sensations in the patient’s stomach area. Experts attribute this to the fact that the daily dose of the drug was 75 g, and the total dose of sorbitol included in the product was too high. No other cases of overdose have been reported.
If you or your loved ones experience side effects that were not described in the instructions, consult a doctor and undergo hemodialysis.
special instructions
When prescribing Nootropil, the doctor must take into account special instructions and precautions:
- the drug is prescribed with caution to patients with malfunctions of hemostasis - a biological function that maintains the fluid state of the blood and is responsible for stopping bleeding. This point applies to patients who have undergone major surgery or are suffering from severe bleeding;
- if Nootropil is used to treat patients with cortical myoclonus, the drug should be discontinued gradually, gradually making the dose smaller. If you do the opposite and abruptly cancel the course of treatment, the attacks will resume.
- Nootropil therapy over a long period of time negatively affects kidney function. When treating elderly patients, it is important to constantly monitor creatinine clearance and change the dose of the drug if necessary.
Drug interactions
Regular use of Nootropil enhances the effect of acenocoumarol (used for the treatment of varicose veins with blood clots). If a combination of Nootropil and acenocoumarol enters the body, blood clotting, fibrinogen levels, and blood and plasma viscosity decrease. The Von Willebrand Factor, which affects pathological blood clotting and the formation of blood clots, also decreases.
The drug does not interact in any way with sodium valproate, phenytoin, clonazenap and phenobarbital. The elimination of the drug from the body also does not change - 90% of the drug leaves the body unchanged in the urine.
If the main active ingredient (piracetam) enters the body in an amount of no more than 20 mg per day, the effect of anticonvulsants does not change. As the dose increases, the anticonvulsant effect may decrease.
The drug practically does not interact with alcoholic beverages. If the product is taken in a volume of 1.6 g, the concentration of active ingredients and ethanol remains unchanged.
Cost, analogues and storage conditions
The cost of Nootropil in ampoules is from 313 rubles. The product should be stored in a place protected from moisture and direct sunlight, at a temperature not exceeding 25 degrees. Storage duration is up to 4 years. Analogs of Nootropil include: Piracetam, Memotropil, Piracetam-Belmed.
INSTRUCTIONS
on medical use of the drug
Registration number:
P N 014242/01Tradename: Nootropil ®
International nonproprietary name:
PiracetamChemical rational name: 2-(2-oxopyrrolidin-1-yl)acetamide
Dosage form:
solution for intravenous and intramuscular administration.Compound
One ampoule contains:
active substance: piracetam - 1 g/5 ml or 3 g/15 ml;
Excipients: sodium acetate trihydrate, glacial acetic acid, water for injection.
Description
Transparent colorless solution.
Pharmacotherapeutic group:
nootropic agent.ATX code: N06BX03.
Pharmacological properties
Pharmacodynamics. The active component is piracetam, a cyclic derivative of gamma-aminobutyric acid (GABA).
Piracetam is a nootropic that directly affects the brain, improving cognitive processes such as learning, memory, attention, and mental performance. Piracetam affects the central nervous system in various ways: by changing the speed of propagation of excitation in the brain, improving metabolic processes in nerve cells, improving microcirculation, affecting the rheological characteristics of the blood and without causing a vasodilator effect.
Improves connections between the cerebral hemispheres and synaptic conduction in neocortical structures, increases mental performance, and improves cerebral blood flow.
Piracetam inhibits platelet aggregation and restores the elasticity of the erythrocyte membrane, reduces the adhesion of erythrocytes. At a dose of 9.6 g, it reduces the level of fibrinogen and von Willebrand factors by 30-40% and prolongs bleeding time.
Piracetam has a protective and restorative effect in cases of impaired brain function due to hypoxia and intoxication.
Piracetam reduces the severity and duration of vestibular nystagmus.
Pharmacokinetics. The half-life of the drug from blood plasma is 4-5 hours and 8.5 hours from cerebrospinal fluid, which is prolonged in case of renal failure.
The pharmacokinetics of piracetam does not change in patients with liver failure.
Penetrates the blood-brain and placental barriers and membranes used in hemodialysis. In animal studies, piracetam selectively accumulates in the tissues of the cerebral cortex, mainly in the frontal, parietal and occipital lobes, in the cerebellum and basal ganglia. It does not bind to plasma proteins, is not metabolized in the body and is excreted unchanged by the kidneys through renal filtration. The renal clearance of piracetam in healthy volunteers is 86 ml/min.
Indications
Symptomatic treatment of psychoorganic syndrome, in particular in elderly patients, accompanied by memory loss, decreased concentration and decreased general activity, mood changes, behavior disorder, gait disturbance, as well as in patients with Alzheimer's disease and dementia of the Alzheimer's type.
Treatment of the consequences of acute cerebrovascular accident (ischemic stroke), such as speech disorders, emotional disturbances, decreased motor and mental activity.
Chronic alcoholism - for the treatment of psychoorganic and withdrawal syndromes.
Comatose states (and during the recovery period), including after injuries and intoxications of the brain.
Treatment of dizziness and related balance disorders, with the exception of dizziness of vascular origin and psychogenic dizziness.
For the treatment of cortical myoclonus as mono- or complex therapy.
As part of complex therapy for sickle cell anemia.
Treatment of dyslexia in children, in combination with other methods, including speech therapy.
Contraindications
Individual intolerance to piracetam or pyrrolidone derivatives, as well as other components of the drug.
Psychomotor agitation at the time of drug administration.
Huntington's chorea.
Acute cerebrovascular accident (hemorrhagic stroke).
End-stage renal failure (with creatinine clearance less than 20 ml/min).
Children under 3 years of age.
Carefully:
Use during pregnancy and lactation
There have been no controlled studies in pregnant women. Piracetam penetrates the placental barrier and into breast milk. The concentration of the drug in newborns reaches 70-90% of its concentration in the mother’s blood. Except in special circumstances, should not be prescribed during pregnancy. You should refrain from breastfeeding when a woman is prescribed piracetam.
Dosage and administration
Parenteral administration of piracetam is prescribed when it is impossible to use oral forms of the drug (tablets, capsules, oral solution), for example, when there is difficulty swallowing or when the patient is in a coma, intravenous administration is preferable.
Bolus intravenous administration (for example, when relieving withdrawal syndrome in alcoholism, emergency treatment of sickle cell anemia, etc.) is performed for at least 2 minutes, the daily dose is distributed over several injections (2-4) at regular intervals so so that the dose per administration does not exceed 3 g.
The drug is administered intramuscularly if administration through a vein is difficult or the patient is overexcited. However, the amount of the drug that can be administered intramuscularly is limited, especially in children and patients with low body weight. In addition, intramuscular administration of the drug can be painful due to the large volume of fluid. The volume of solution administered intramuscularly cannot exceed 5 ml. The frequency of administration of the drug is similar to that for intravenous or oral administration.
When the opportunity arises, switch to oral administration of the drug (see instructions for medical use of the corresponding forms of release of the drug).
The duration of treatment is determined by the doctor depending on the disease and taking into account the dynamics of symptoms.
Symptomatic treatment of chronic psychoorganic syndrome. 2.4-4.8 g / day.
Treatment of cerebrovascular disorders (stroke). 4.8-12 g / day.
Treatment of comatose states, as well as difficulties of perception in people with brain injuries. The initial dose is 9-12 g/day, maintenance dose is 2 g/day. Treatment is continued for at least 3 weeks.
Alcohol withdrawal syndrome. 12 g/day Maintenance dose 2.4 g/day.
Treatment of dizziness and related balance disorders- 2.4-4.8 g / day.
Cortical myoclonus. Treatment begins with a dose of 7.2 g/day, every 3-4 days the dose is increased by 4.8 g/day until a maximum dose of 24 g/day is reached. Treatment is continued throughout the entire period of the disease. Every 6 months, attempts should be made to reduce the dose or discontinue the drug, gradually reducing the dose by 1.2 g/day every 2 days. If there is no effect or insignificant therapeutic effect, treatment is stopped.
Sickle cell anemia. The daily prophylactic dose is 160 mg/kg body weight, divided into 4 equal doses. During a crisis - 300 mg/kg intravenously, divided into 4 equal doses.
Dosing in patients with impaired renal function.
Since Nootropil ® is excreted from the body by the kidneys, caution should be exercised when treating patients with renal failure and the dose should be selected in accordance with this dosage regimen:
In elderly patients, the dose is adjusted in the presence of renal failure, and with long-term therapy, monitoring of the functional state of the kidneys is necessary.
Treatment of dyslexia in children (in combination with speech therapy). The recommended daily dose for children over 8 years of age and adolescents is 3.2 g, divided into 2 administrations.
Dosing in patients with impaired liver function.
Patients with impaired liver function do not need dose adjustment. For patients with impaired renal and liver function, dosing is carried out according to the scheme (see section "Dosing for patients with impaired renal function").
Side effect
From the cardiovascular system: rarely - a decrease or increase in blood pressure.
From the digestive system: in isolated cases - nausea, vomiting, diarrhea, abdominal pain (including gastralgia).
From the side of metabolism: weight gain (1.29%) - occurs more often in elderly patients receiving the drug at a dose of more than 2.4 g/day.
From the skin: dermatitis, itching, rashes.
Allergic reactions: angioedema.
Overdose
Symptoms: A single case of the development of dyspeptic symptoms in the form of diarrhea with blood and pain in the abdominal area was registered when taking the drug orally at a daily dose of 75 g. Apparently, this was associated with the use of a large total dose of sorbitol, which is part of the drug. No other cases of drug overdose have been identified.
Treatment: In case of overdose, symptomatic therapy is recommended, which may include hemodialysis. There is no specific antidote. The effectiveness of hemodialysis for piracetam is 50-60%.
Interaction with other drugs
Piracetam increases the effectiveness of thyroid hormones and antipsychotic drugs (neuroleptics). When administered simultaneously with antipsychotics, piracetam reduces the risk of extrapyramidal disorders. When used simultaneously with drugs that have a stimulating effect on the central nervous system, the stimulating effect on the central nervous system may be enhanced.
There was no interaction with clonazepam, phenytoin, phenobarbital, or valproic acid.
High doses (9.6 g/day) of piracetam increase the effectiveness of indirect anticoagulants in patients with venous thrombosis (there was a greater decrease in platelet aggregation, fibrinogen levels, von Willebrand factors, blood and plasma viscosity compared with the use of indirect anticoagulants only).
The possibility of changing the pharmacodynamics of piracetam under the influence of other drugs is low, since 90% of the drug is excreted unchanged in the urine.
In vitro piracetam does not inhibit cytochrome P450 isoenzymes, such as CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1 and 4A9/11 at concentrations of 142, 426 and 1422 μg/ml. At a concentration of 1422 mcg/ml, a slight inhibition of CYP2A6 (21%) and 3A4/5 (11%) was noted, however, the Ki level of these two isoenzymes is sufficient when exceeding 1422 mcg/ml, and therefore metabolic interaction with other drugs is unlikely.
Taking piracetam at a dose of 20 mg/day did not change the peak and curve of the concentration of antiepileptic drugs in the blood serum (carbamazepine, phenytoin, phenobarbital, valproic acid) in patients with epilepsy receiving a constant dosage.
Co-administration with alcohol did not affect the serum concentration of piracetam, and the serum alcohol concentration did not change with 1.6 g of piracetam.
special instructions
Due to the effect of piracetam on platelet aggregation, caution is recommended when prescribing the drug to patients with impaired hemostasis, during major surgical operations, or to patients with symptoms of severe bleeding. When treating patients with cortical myoclonus, abrupt interruption of treatment should be avoided, which may cause resumption of attacks.
During long-term therapy in elderly patients, regular monitoring of renal function indicators is recommended; if necessary, dose adjustment is carried out depending on the results of a creatinine clearance study.
Taking into account possible side effects, caution should be exercised when operating machinery or driving a vehicle. Penetrates through the filter membranes of hemodialysis machines.
Release form
Solution for intravenous and intramuscular administration 200 mg/ml. 5 or 15 ml of solution in colorless glass ampoules (type I, Ev. F.). 4 (15 ml each) or 6 (5 ml each) ampoules on cardboard or plastic pallets. 1 (4 ampoules each) or 2 (6 ampoules each) pallets along with instructions for use in a cardboard box.
Storage conditions
At a temperature not higher than 30°C.
Keep the medicine out of the reach of children!
Best before date
5 years in original packaging.
Do not use after the expiration date stated on the package.
Conditions for dispensing from pharmacies
On prescription.
Manufacturer
USB Pharma S.p.A., Via Praglia 15, I-10044 Pianezza (Turin) - ITALY
Representative office in Russia / Organization accepting claims
119049 Moscow, st. Shabolovka, 10, building 2 (BC "CONCORD")
A drug Nootropil- nootropic drug. The active ingredient of Nootropil is piracetam, a cyclic derivative of GABA (γ-aminobutyric acid). Piracetam improves cognitive or cognitive processes of the brain, such as memory, learning, attention. Increases mental performance. The drug has an effect on the central nervous system through several mechanisms of action: improves neuronal metabolic processes, changes in the rate of propagation of the excitation process, improves microcirculation due to the stabilization of the rheological properties of blood.
Improvement of the rheological properties of blood occurs due to the suppression of the aggregation properties of platelets, reducing the adhesiveness of erythrocytes and improving the elastic properties of erythrocyte membranes.
Does not have a vasodilating effect. The drug also improves cerebral circulation parameters, improves synaptic conduction of neocortical structures and the interaction of the cerebral hemispheres.
In case of brain dysfunction due to intoxication and hypoxia, nootropil has a restorative and protective effect. There is also a decrease in the duration and severity of vestibular nystagmus.
Indications for use
Indications for use of the drug Nootropil are:- Coma (including comatose state of post-traumatic and toxic origin), recovery period after coma;
- For symptomatic treatment of psychoorganic syndrome, including elderly patients with memory loss, mood changes, decreased ability to concentrate, gait disturbance, dizziness, behavioral disorder;
- Improving mental and motor activity, therapy for emotional and speech disorders in patients who have suffered an ischemic stroke;
- Alzheimer's disease (including senile dementia of the Alzheimer's variant);
- Chronic alcoholism - for the treatment of psychoorganic syndrome and abstinence;
- Psychoorganic syndrome in children with learning disabilities (as a component of complex therapy);
- Balance disorders, dizziness (except for diseases caused by psychogenic and vasomotor disorders);
- As part of complex treatment of sickle cell anemia;
- Cortical myoclonus (as a component of complex therapy or monotherapy).
Mode of application
Nootropil prescribed for adults in doses from 30 to 160 mg/kg of patient body weight. The daily dose of the drug is divided into 2-4 times. Nootropil in capsules, tablets and solution for internal use is taken orally before meals or during meals. The liquid for washing down capsules or tablets can be water or juice. If it is impossible to take the drug orally, a parenteral route of administration is prescribed.Psychoorganic syndrome: 4.8 g/day for the first 7 days, maintenance dosage - 1.2-2.4 g/day.
Consequences of stroke (ischemic): 4.8 g/day.
Comatose states: starting dosage - 9-12 g/day, maintenance dosage - 2.4 g/day. The course of treatment is 3 weeks.
Balance disorders and dizziness: 2.4-4.8 g/day.
Sickle cell anemia: prophylactic dose - 160 mg/kg/day (divided into 4 injections). During a disease crisis, it is necessary to increase the dose to 300 mg/kg (intravenously). This dose can also be prescribed in pediatrics - for children from 1 year of age.
To correct learning disability: 3.3 g/day throughout the entire academic year.
Chronic alcoholism: during the manifestation of withdrawal syndrome after alcohol withdrawal - 12 g / day, then switch to a maintenance dosage - 2.4 g / day.
Cortical myoclonus: starting dosage - 7.2 g/day. Every 3-4 days, the dose is increased by 4.8 g/day until the maximum effective dose of 24 g/day is reached. The course of treatment depends on how long the symptoms of the disease continue. However, every 6 months attempts are made to cancel Nootropil or reduce its dose (1.2 g/day every 2 days). Piracetam therapy is discontinued if the drug is insufficiently effective or if there is no therapeutic effect.
Dose adjustments are made to patients with changes in renal function or the elderly (the latter may experience an age-related decrease in creatinine clearance). Persons with a creatinine clearance of 80 ml/min or more are prescribed the usual dosage. With a clearance of 79-50 ml/min - 2/3 of the recommended dose (in 2-3 doses); 49-30 ml/min - 1/3 dose in 2 doses; 29-20 ml/min - 1/6 of the recommended dose in 1 dose. Nootropil is contraindicated for persons with creatinine clearance less than 20 ml/min.
No dosage change is required for patients with impaired liver function.
Side effects
Nootropil may cause side effects when used:From the central nervous system: nervousness (1.13%), hyperkinetic disorders (1.72%), depression (0.83%), drowsiness (0.96%), asthenia (0.23%). They are more common in the elderly when using dosages above 2.4 g/day. The following may also occur: headache, dizziness, ataxia, imbalance, insomnia, exacerbation of epilepsy, agitation, confusion, anxiety, increased libido, hallucinations.
From the gastrointestinal tract: abdominal pain, vomiting, nausea, diarrhea.
Allergic reactions: itching, dermatitis, swelling, rash.
Others: increased body weight (1.29%).
Contraindications
:Contraindications to the use of the drug Nootropil are: renal failure with creatinine clearance of 20 or less ml/min; hemorrhagic stroke; age up to 1 year; individual hypersensitivity to pyrrolidone, piracetam and other components of Nootropil.
Pregnancy
:Adequate clinical studies on the safety of use Nootropil Not performed in pregnant women. The active substance of the drug can penetrate into breast milk and through the hematoplacental barrier. In newborns, the concentration of piracetam in the blood is determined to be 70-90% of the concentration in the mother’s blood.
The drug is not prescribed to pregnant women, except in cases of vital importance of using the drug. If Nootropil is prescribed to nursing mothers, breastfeeding is temporarily abandoned. Experiments conducted on animals have not proven any teratogenic or other effects of piracetam on the developing fetus, pregnancy, childbirth and the newborn.
Interaction with other drugs
In combination Nootropil with triiodothyronine, tetraiodothyronine and thyroid extracts, confusion, irritability and sleep disturbances may occur.No interaction of the drug with sodium valproate, phenytoin, clonazepam, or phenobarbital has been identified.
Significant doses of the drug (approximately 9.6 g/day) caused an increase in the effectiveness of acenocoumarol in venous thrombosis, which was manifested by a pronounced decrease in platelet aggregation properties, a decrease in the level of von Willebrand factor, fibrinogen and the viscosity of plasma and blood.
The likelihood of changes in pharmacodynamic parameters when combined with other drugs is quite low, since 90% of piracetam is eliminated from the body unchanged.
In vitro studies did not reveal inhibition of the isoenzymes CYP1A2, 2C8, 2B6, 2C9, 4A9/11, 2D6, 2C19, and 2E1 of the cytochrome P450 system under the influence of piracetam at concentrations of 426, 142 and 1422 μg/ml.
However, the Ki level of both isoenzymes when the dose of 1422 μg/ml is exceeded is quite sufficient. Therefore, metabolic interaction of piracetam with other drugs is unlikely.
The concentration curve and peak in the blood serum of antiepileptic drugs (carbamazepine, phenobarbital, phenytoin, valproate) did not change when taking piracetam at a dosage of 20 mg/day, provided that the same doses of drugs for the treatment of epilepsy were received.
The combination of alcohol (ethanol) and piracetam does not change the content of piracetam in the blood serum and the concentration of ethanol (if used simultaneously with 1.6 g of piracetam).
Overdose
:When the dose of 75 g (oral solution) was exceeded, the symptoms were: abdominal pain, bloody diarrhea (this is probably due to the high concentration of sorbitol in this dosage form of the drug). No specific symptoms of overdose have been identified. In case of overdose Nootropil, taken orally, gastric lavage, initiation of vomiting, symptomatic therapy, hemodialysis are recommended (the effectiveness of the latter is 50-60%). A specific antidote is unknown.
Storage conditions
In a dry place, at a temperature not exceeding 25 °C.Keep out of the reach of children.
Release form
Capsules Nootropil - 400 mg. There are 60 pieces in a blister, 4 blisters in a cardboard package.Nootropil tablets - 800 mg. 15 pieces in a blister pack, 2 packs in a cardboard box. 10 pieces in a blister pack, 2 packs in a cardboard box.
Solution for internal use Nootropil 20%. The bottle contains 125 ml of solution. The cardboard pack contains a bottle with a dosage glass.
Solution for injection Nootropil 20%, 1 ampoule - 5 ml. There are 5 ampoules in a cardboard box.
Solution for intravenous administration Nootropil 20%. 1 bottle contains 15 ml. There are 3 bottles in a cardboard box.
Compound
:1 capsule Nootropil contains: active substance: piracetam - 400 mg.
Additional components: macrogol 6000, colloidal silicon anhydride (Aerosil R972), magnesium stearate, lactose.
Capsule shell components: gelatin, titanium dioxide (E171), purified water.
1 tablet Nootropil contains active substance: piracetam - 800 mg.
Additional components: colloidal silicon anhydride (Aerosil R972), macrogol 6000, magnesium stearate, croscarmellose sodium, titanium dioxide (E171), hydroxypropyl methylcellulose, macrogol 400.
Solution for internal use Nootropil
Additional components: glycerol, sodium saccharin, sodium acetate, propyl hydroxybenzoate, methyl parahydroxybenzoate, apricot flavor, caramel flavor, glacial acetic acid, purified water.
Solution for injection Nootropil contains the active substance: piracetam.
Solution for intravenous administration Nootropil contains the active substance: piracetam.
Additional components: sodium acetate, sodium chloride, glacial acetic acid, water for injection.
Additionally
:Nootropil appoint with caution to patients with a violation of the blood coagulation system, during major surgical interventions, with severe bleeding.
Abrupt withdrawal of Nootropil in patients with myoclonus may provoke the resumption of seizures.
In the elderly with long-term treatment with the drug, regular monitoring of renal function indicators is necessary. The dose of piracetam is adjusted with changes in the level of creatinine clearance.
Piracetam penetrates through the filter membranes of hemodialysis machines.
When driving vehicles and engaging in production related to the operation of complex mechanisms, caution is required, given the possible side effects.
