home Analyzes Nise method of application and dose. Instructions for use and composition of Nise tablets

Nise method of application and dose. Instructions for use and composition of Nise tablets

Wide choice pharmacological drugs allows you not to endure bad feeling, and fight it with the help of various medical supplies. There are times when the body itself finds it difficult to cope with viruses, fever, and diseases. In such cases, remedies are very effective that help not only relieve pain and mask the problem, but also solve it. One of these drugs is Nise tablets. According to the annotation, the drug belongs to the group of non-steroidal anti-inflammatory drugs; it is a good non-narcotic analgesic and antipyretic agent.

Indications for use of Nise tablets

There are many reasons for prescribing the drug. The most common:

joint damage from rheumatism;
(as well as psoriatic and other types);
exacerbation of gout;
muscle and joint pain;
radiculitis;
sharp pains lower back;
bursitis (inflammation of the mucous bursae, often in the joint area);
inflammatory processes different origins;
Bekhterev's disease;
elevated temperature;
pain: headache, dental, menstrual.

When using the drug, it is necessary to take into account that Nise tablets can alleviate the symptoms of the disease: eliminate pain, reduce temperature and inflammation. The drug does not fight pathology. To eliminate the main cause of symptoms, tablets are used in combination with other drugs aimed at treating pathology.

Composition of Nise in tablets

Wide range The use of these tablets is determined by the composition. Active substance Nysa is nimesulide. This component is capable of providing antiplatelet, antipyretic, analgesic, analgesic and anti-inflammatory effects. The content in 1 tablet is 50 or 100 mg (depending on the dosage). In addition to it, there are other substances that help eliminate the symptoms of the disease (calculation of content was made for Nise 100 mg tablets):

Instructions for use and dosage

Proper Use drugs medical purposes reduces the risk of side effects or any other unwanted effects. It is recommended to take Nise tablets immediately after meals. Use before meals can cause unpleasant symptoms. Swallow the tablet whole without crushing it first. You need to drink Nise big amount water, approximately 100-200 ml.

It is allowed to give tablets to children over 12 years of age and adults in the same dosage. Persons over 65 years of age are prescribed the same dose. If renal failure is detected with creatine clearance determined using the Rehberg test of at least 30 ml/min, the dose of Nise is not reduced; if this figure is lower, the use of tablets is strictly prohibited.

Nise 100 mg is not prescribed for children under 12 years of age. At the age of 3 to 12 years, dispersible (dissolving in the mouth) tablets are allowed. Up to 3 years of age (children under 2 months of age are not given the drug) use Nise suspension. It is not recommended to use the tablets during pregnancy and breastfeeding. If there is a high need to use Nise during lactation, you should stop feeding while using the drug.

To eliminate pain, relieve fever, reduce inflammatory processes Nise is recommended to take 1 tablet 2 times a day. It is advisable to maintain the same period of time between doses (every 12 hours). If necessary, it is allowed to increase the dose to 400 mg/day. The drug should not be used more than 6 hours and more than 4 tablets in 24 hours. Failure to comply with these standards causes an overdose.

The use of Nise sometimes causes adverse reactions:

Digestive system – nausea, stomach pain, vomiting, diarrhea, toxic hepatitis, erosions, ulcers.
Nervous system– dizziness, pain.
Circulatory system– anemia, leukopenia.
Allergic reactions– skin rash, bronchospasm, anaphylactic shock.

Contraindications

In addition to the fact that Nise is contraindicated for children in early age and women during pregnancy and lactation, tablets should not be used for:

exacerbation of erosions and ulcers in gastrointestinal tract;
bleeding from organs digestive system;
aspirin triad syndrome - intolerance to aspirin together with nasal polyps and bronchial asthma;
damage and infection skin, dermatoses (in cases of gel use);
intolerance to any substance from the composition.

The drug should be prescribed with extreme caution to patients with:

heart failure;
arterial hypertension.

Where to buy and how much the drug costs

You can buy Nise in pharmacies of the Farmavita, Omega, Neo-Pharm, Max-Pharm, Medfarm and many others. It is possible to buy tablets on online store sites such as piluli.ru, amt.allergist.ru, wer.ru. The cost of Nise 100 mg tablets No. 20 ranges from 185 to 279 rubles. per package. Prices for the medicine are indicated at the time of writing this article; they may change in the future. Check the exact cost of Nise in pharmacies or on websites.

Analogs of Nise in tablets

The drug also has its own analogues, i.e. funds with the same international generic name or ATC code. Most are painkillers. They may differ slightly in composition and pricing policy. If you are looking for a substitute for Nise tablets, check out the most common drugs:

When choosing cheaper substitutes for Nise, you should not be guided only by the price of the drug. First of all, consult with your doctor, who can determine whether the analogue will fully replace the prescribed tablets. Making such decisions on your own or in consultation with a pharmacy pharmacist sometimes results in unpleasant consequences, in which losses exceed the money saved on medicines.

The page contains instructions for use Nise. It is available in various dosage forms drug (50 mg and 100 mg tablets, 1% gel, suspension or syrup), and also has a number of analogues. This abstract has been verified by experts. Leave your feedback on using Nise, which will help other site visitors. The drug is used for various diseases(pain and inflammation due to arthrosis, arthritis, injuries). The product has a number side effects and features of interaction with other substances. Doses of the drug differ for adults and children. There are restrictions on the use of the medicine during pregnancy and breastfeeding. Treatment for Nise can only be prescribed by a qualified doctor. The duration of therapy may vary and depends on the specific disease.

Instructions for use and dosage

Pills

Adults are prescribed 100 mg orally 2 times a day. Maximum daily dose- 400 mg.

It is preferable to take the drug in the form of a suspension before meals, but if you feel discomfort in the stomach, you can take it at the end or after a meal.

The drug in the form of dispersible tablets should be taken at the end or after meals. Before taking, 1 tablet is dissolved in 5 ml (1 teaspoon) of water.

For children over 2 years of age, the drug is prescribed in the form of a suspension, for children over 3 years of age - in the form of dispersible tablets or suspensions, for children over 12 years of age, the drug can be prescribed in the form of tablets (100 mg 2 times a day). The recommended dose is 3-5 mg/kg body weight 2-3 times a day. Maximum dose- 5 mg/kg per day in 2-3 doses. For adolescents weighing more than 40 kg, the drug is prescribed 100 mg 2 times a day.

The maximum dose is 5 mg/kg body weight per day. The duration of use of the drug is 10 days.

Gel

Before using the gel, wash and dry the skin surface. Apply a strip of gel approximately 3 cm long in an even thin layer, without rubbing, to the area of maximum pain 3-4 times a day.

The amount of gel and the frequency of its use (no more than 4 times a day) varies depending on the size of the skin area being treated and the patient’s reaction.

The maximum dose is 5 mg/kg per day (30 g per day). The duration of use of the drug is no more than 10 days without consulting a doctor.

Release forms

Tablets 100 mg.

Dispersible tablets 50 mg (can be used to prepare a suspension or syrup by dissolving in water, this form is convenient for use in children).

Gel for external use 1%.

Nise- non-steroidal anti-inflammatory drug. Selective inhibitor COX-2 is an enzyme involved in the synthesis of prostaglandins - mediators of edema, inflammation and pain. The drug has anti-inflammatory, analgesic and antipyretic effects.

Reversibly inhibits the formation of prostaglandin E2, both at the site of inflammation and in upward paths nociceptive system, including the pathways for pain impulses in the spinal cord.

Reduces the concentration of short-lived prostaglandin H2, from which prostaglandin E2 is formed under the action of prostaglandin isomerase. A decrease in the concentration of prostaglandin E2 leads to a decrease in the degree of activation of EP-type prostanoid receptors, which is expressed in analgesic and anti-inflammatory effects.

It has a slight effect on COX-1 and practically does not interfere with the formation of prostaglandin E2 from arachidonic acid under physiological conditions, thereby reducing the number of side effects of the drug.

Nise suppresses platelet aggregation by inhibiting the synthesis of endoperoxides and thromboxane A2, and inhibits the synthesis of platelet aggregation factor. Suppresses the release of histamine and also reduces the degree of bronchospasm caused by exposure to histamine and acetaldehyde.

It has been shown that nimesulide ( active substance drug Nise) is able to suppress the synthesis of interleukin-6 and urokinase, thereby preventing the destruction cartilage tissue. Inhibits the synthesis of metalloproteases (elastase, collagenase), preventing the destruction of proteoglycans and collagen of cartilage tissue.

It has antioxidant properties and inhibits the formation of toxic oxygen breakdown products by reducing the activity of myeloperoxidase. Interacts with glucocorticoid receptors, activating them through phosphorylation, which also enhances the anti-inflammatory effect of the drug.

At local application causes a weakening or disappearance of pain at the site of application of the gel, incl. joint pain at rest and during movement, reduces morning stiffness and swelling of the joints. Helps increase range of motion.

Pharmacokinetics

After oral administration, Nise is well absorbed from the gastrointestinal tract. Eating reduces the rate of absorption without affecting its extent. Penetrates into the tissues of the female genital organs, where after a single dose the concentration of nimesulide is about 40% of the concentration in plasma. Penetrates well into the acidic environment of the inflammation site (40%) and synovial fluid (43%). Easily penetrates histo-hematological barriers. The metabolite is excreted by the kidneys (65%) and bile (35%).

Indications

rheumatoid arthritis;
articular syndrome with rheumatism and exacerbation of gout;
psoriatic arthritis;
ankylosing spondylitis;
osteochondrosis with radicular syndrome;
radiculitis;
sciatica;
lumbago;
osteoarthritis;
arthritis of various etiologies;
arthralgia;
myalgia of rheumatic and non-rheumatic origin;
inflammation of ligaments, tendons, bursitis;
post-traumatic inflammation of soft tissues and the musculoskeletal system (damage and rupture of ligaments, bruises);
pain syndrome of various origins(including in postoperative period, for injuries, algodismenorrhea, toothache, headache);
fever of various origins (including infectious and inflammatory diseases).

Contraindications

erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
bleeding from the gastrointestinal tract;
"aspirin triad";
liver dysfunction;
pronounced renal failure(QC<30 мл/мин);
pregnancy;
lactation (breastfeeding);
dermatoses, damage to the epidermis, skin infections in the area of application (for gel);
children under 2 years of age;
hypersensitivity to nimesulide and other components of the drug, acetylsalicylic acid and other non-steroidal anti-inflammatory drugs (NSAIDs).

special instructions

Nise should be prescribed with caution to patients with impaired renal function and visual impairment.

With long-term use, it is necessary to monitor liver and kidney functions.

When using the drug in elderly patients, no dosage adjustment is required.

Impact on the ability to drive vehicles and operate machinery

Due to the fact that Nise, when taken orally, can cause dizziness and drowsiness, the drug should be prescribed with caution to patients engaged in potentially hazardous activities that require increased concentration and rapid psychomotor reactions.

Side effect

heartburn;
nausea, vomiting;
pain in the stomach;
diarrhea;
erosive and ulcerative lesions of the gastrointestinal tract;
headache;
dizziness;
thrombocytopenia, leukopenia, anemia, agranulocytosis;
skin rash;
anaphylactic shock;
bronchospasm;
fluid retention;
prolongation of bleeding time;
hematuria (blood in the urine);
when applying the gel - itching, urticaria, peeling, transient change in skin color (does not require discontinuation of the drug).

Drug interactions

Manifestations of drug interactions are possible (due to competition between drugs for binding to proteins) when taking Nise orally with digoxin, phenytoin, lithium drugs, diuretics, antihypertensive drugs, other NSAIDs, anticoagulants, cyclosporine, methotrexate, and oral hypoglycemic agents.

Analogues of the drug Nise

Structural analogues of the active substance:

Use in children

Contraindicated in children under 2 years of age.

Use during pregnancy and breastfeeding

Nise is contraindicated for use during pregnancy.

If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.

Nise

Compound

The chemical composition of Nise in tablets and dispersible tablets is the same.
The main active substance is nimesulide. Auxiliary elements: calcium phosphate, microcrystalline cellulose, corn starch, magnesium stearate, sodium glycolate, colloidal silicon dioxide, talc, aspartame, flavoring.

The chemical composition of Nise in the form of an oral suspension differs from the drug in tablet form. Nimesulide is the main active substance. Excipients: sorbitol, sucrose, propylparaben, methylparaben, citric acid monohydrate, xanthan gum, polysorbate 80, choline yellow WS, pineapple flavor #1 and purified water.

The chemical composition of the gel is as follows. Nimesulide is the main active element. Excipients: propylene glycol, N-methyl-2-pyrrolidone, PEG-400, isopropanol, butylated hydroxyanisole, carbomer-940, thimserosal, potassium phosphate, flavoring, water.

pharmachologic effect

The drug has antipyretic, anti-inflammatory, analgesic and antiplatelet effects. Suppresses the formation of prostaglandin at the site of inflammation, selectively inhibits COX2. Rarely may cause side effects due to inhibition of prostaglandin synthesis in healthy tissues. Slows down lipid peroxidation and has no effect on phagocytosis and hemostasis. When taken orally, it is absorbed quite well from the gastrointestinal tract. The maximum concentration of the drug is achieved 1.5–2.5 hours after administration. Its half-life is 3 hours. The main metabolite in its composition is the active hydroxynimesulide. This drug is biotransformed in the liver. Excretion is carried out mainly by the kidneys. Does not accumulate with prolonged use.

The drug in the form of a gel has a local anti-inflammatory analgesic effect. With its help, pain in the joints weakens or disappears during movement and rest. Swelling and morning stiffness of joints are neutralized.

Indications for use

This drug is prescribed for the following diseases: osteoarthritis, osteoarthritis, bursitis, tendovaginitis, tendonitis, rheumatism, ankylosing spondylitis, muscle pain, post-traumatic pain, spinal pain, infectious diseases, all kinds of inflammatory processes, febrile syndrome, myalgia and neuralgia.

Nise in the form of a gel is used for degenerative and inflammatory diseases of the musculoskeletal system, such as rheumatoid and psoriatic arthritis, articular syndrome with exacerbation of gout and rheumatism, radiculitis, osteochondrosis with radicular syndrome, osteoarthritis, lumbago, bursitis, sciatica, inflammatory damage to tendons and ligaments .

Mode of application

The drug is taken orally. For adults, two doses per day of 100 mg are prescribed. If necessary, the daily dose can be increased to a maximum of 400 mg.
Experts recommend taking the suspension or tablets before meals, but if you experience discomfort in the stomach, you can take the drug after meals.

Nise, available in the form of dispersible tablets, should be dissolved in water (one tablet per teaspoon) and taken after meals.
For children over two years of age, the medicine is prescribed in the form of a suspension, for children over three years of age - in the form of a suspension or dispersible tablets. Older children (12 years and older) can take the tablets. The optimal dose for them should be calculated based on body weight: 3-5 mg per kg. Adolescents who have reached a weight of 40 kg can take the medicine at an adult dose - 100 mg twice a day.

Nise in the form of a gel is applied to the skin. Before this, the desired area of skin should be thoroughly washed and dried. A column of gel, 3 cm long, is applied to the most painful area and rubbed to a thin, uniform layer. This procedure should be carried out 3-4 times a day.

The drug can be used for 10 days.

Side effects

When using this medication, the following side effects have been noted: headache, drowsiness, dizziness, nausea, diarrhea, vomiting, heartburn, gastralgia, stomach pain, tarry stools, toxic hepatitis, ulceration of the mucous membrane of the gastrointestinal tract, petechiae, melena; purpura, oliguria, fluid retention, anemia, leukopenia, thrombocytopenia, agranulocytosis, hematuria, high activity of “liver” transaminases. Various allergic reactions such as anaphylactic shock or skin rash also occur.

When using the gel, local adverse reactions may occur: urticaria, itching, peeling of the skin. If there is a transient change in skin color, then discontinuation of the medication is not required. When applying the gel to large areas of the skin, one cannot exclude systemic side effects that are typical when taking tablets and are listed above.

If any side effects are noticed, you should stop taking the medication and consult a doctor for advice.

Contraindications

The drug is contraindicated in case of peptic ulcer of the gastrointestinal tract in the acute stage, hypersensitivity to the components of the drug, liver failure, “aspirin” asthma, renal failure. Also, the drug should not be used for congestive heart failure, type 2 diabetes mellitus, arterial hypertension, pregnancy, or lactation. The drug in tablet form is contraindicated for children under 12 years of age; children under two years of age should not take this medicine in any form.

There are additional contraindications for the use of Nise gel: damage to the epidermis, dermatoses and various skin infections in the area of application.

Pregnancy

During pregnancy and lactation, the use of this drug is prohibited. If there is an urgent need to use Nise, then breastfeeding should be stopped.

Drug interactions

The drug may increase the effectiveness and toxicity of some drugs due to competition between drugs for binding to plasma proteins. Nise interacts with phenytoin, digoxin, antihypertensive drugs, lithium drugs, diuretics, other NSAIDs, cyclosporine, methotrexate, anticoagulants, and oral hypoglycemic agents.

Overdose

Symptoms of overdose are an increase in the severity of adverse reactions. As a rule, this is impaired renal function, liver failure, irritation of the gastrointestinal tract, convulsions, respiratory depression, and increased blood pressure.

If any of these symptoms appear, you should immediately stop taking the drug and provide treatment: first of all, rinse the stomach, take activated charcoal and carry out symptomatic therapy. There is no clearly defined antidote. Hemodialysis and forced diuresis do not bring the desired results.

Release form

The drug is distributed in the form of 100 mg tablets, 50 mg dispersible tablets, 50 mg/5 ml oral suspension, and also as a 1% gel.

Storage conditions

Nise, presented in the form of regular and dispersible tablets, should be stored in a dry place, protected from light. Storage temperature should not exceed 25°C. The maximum shelf life is 3 years.

Nise gel is stored at a temperature not exceeding 25°C; freezing is prohibited. The shelf life of the drug is 2 years.

Nise in the form of a suspension or tablets of the regular and dispersible type is dispensed from pharmacies with a doctor’s prescription. Nise gel is an over-the-counter medicine.

Additionally

Long-term use of this drug requires constant monitoring of kidney function. Elderly people with cardiovascular and other diseases should take Nise with caution.

Avoid getting the gel on damaged skin, open wounds, eyes and other mucous membranes of the body. After using the gel, hands should be washed thoroughly.

Since the drug can cause drowsiness and dizziness, it should be prescribed with caution to patients whose activities require reaction time and increased attention, such as drivers.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

Name:

Nise

Pharmacological
action:

The drug has antipyretic, anti-inflammatory, analgesic and antiplatelet effect. Suppresses the formation of prostaglandin at the site of inflammation, selectively inhibits COX2. Rarely may cause side effects due to inhibition of prostaglandin synthesis in healthy tissues. Slows down lipid peroxidation and has no effect on phagocytosis and hemostasis. When taken orally, it is absorbed quite well from the gastrointestinal tract. The maximum concentration of the drug is achieved 1.5–2.5 hours after administration. Its half-life is 3 hours. The main metabolite in its composition is the active hydroxynimesulide. This drug is biotransformed in the liver. Excretion is carried out mainly by the kidneys. Does not accumulate with prolonged use.

The drug is in the form of a gel has a local anti-inflammatory analgesic effect. With its help, pain in the joints weakens or disappears during movement and rest. Swelling and morning stiffness of joints are neutralized.

Indications for
application:

This drug prescribed for the following diseases: osteoarthrosis, osteoarthritis, bursitis, tendovaginitis, tendinitis, rheumatism, ankylosing spondylitis, muscle pain, post-traumatic pain, spinal pain, infectious diseases, all kinds of inflammatory processes, febrile syndrome, myalgia and neuralgia.

Nise in gel form used for degenerative and inflammatory diseases of the musculoskeletal system, such as rheumatoid and psoriatic arthritis, articular syndrome with exacerbation of gout and rheumatism, radiculitis, osteochondrosis with radicular syndrome, osteoarthritis, lumbago, bursitis, sciatica, inflammatory damage to tendons and ligaments.

Mode of application:

The drug is taken orally. For adults, two doses per day of 100 mg are prescribed. If necessary, the daily dose can be increased to a maximum of 400 mg.
Experts recommend taking the suspension or tablets before meals, but if you experience discomfort in the stomach, you can take the drug after meals.

Nise, presented in the form of dispersible tablets, should be dissolved in water (one tablet per teaspoon) and taken after meals.
Children over two years old the medicine is prescribed in the form of a suspension; for children over three years of age - in the form of a suspension or dispersible tablets. Older children (12 years and older) can take the tablets. The optimal dose for them should be calculated based on body weight: 3-5 mg per kg. Adolescents who have reached a weight of 40 kg can take the medicine at an adult dose - 100 mg twice a day.

Nise in gel form applied to the skin. Before this, the desired area of skin should be thoroughly washed and dried. A column of gel, 3 cm long, is applied to the most painful area and rubbed to a thin, uniform layer. This procedure should be carried out 3-4 times a day.

The drug can be used for 10 days.

Side effects:

While using this medicine The following side effects have been noted: headache, drowsiness, dizziness, nausea, diarrhea, vomiting, heartburn, gastralgia, stomach pain, tarry stools, toxic hepatitis, ulceration of the gastrointestinal mucosa, petechiae, melena; purpura, oliguria, fluid retention, anemia, leukopenia, thrombocytopenia, agranulocytosis, hematuria, high activity of “liver” transaminases. Various allergic reactions such as anaphylactic shock or skin rash also occur.

When using gel Local adverse reactions may occur: urticaria, itching, peeling of the skin. If there is a transient change in skin color, then discontinuation of the medication is not required. When applying the gel to large areas of the skin, one cannot exclude systemic side effects that are typical when taking tablets and are listed above.

If any side effects are noticed, you should stop taking the medication and consult a doctor for advice.

Contraindications:

Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
- bleeding from the gastrointestinal tract;
- “aspirin triad”;
- liver dysfunction;
- severe renal failure (CR<30 мл/мин);
- pregnancy;
- lactation (breastfeeding);
- dermatoses, damage to the epidermis, skin infections in the area of application (for gel);
- children under 2 years of age;
- hypersensitivity to nimesulide and other components of the drug, acetylsalicylic acid and other NSAIDs.
Prescribe with caution drug for arterial hypertension, heart failure, diabetes mellitus type 2 (non-insulin dependent).

Interaction
other medicinal
by other means:

Potential drug interactions(due to competition between drugs for binding to proteins) while taking Nise orally with digoxin, phenytoin, lithium drugs, diuretics, antihypertensive drugs, other NSAIDs, anticoagulants, cyclosporine, methotrexate, oral hypoglycemic agents.

Pregnancy:

Nise contraindicated for use during pregnancy.
If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.

Overdose:

Symptoms overdose is an increase in the severity of adverse reactions. As a rule, this is impaired renal function, liver failure, irritation of the gastrointestinal tract, convulsions, respiratory depression, and increased blood pressure.

Treatment: If any of these symptoms appear, you should immediately stop taking the drug and provide treatment: first of all, rinse the stomach, take activated charcoal and carry out symptomatic therapy. There is no clearly defined antidote. Hemodialysis and forced diuresis do not bring the desired results.

Suspension for oral administration yellow in color, with a pleasant odor and characteristic taste, redisperses when shaken.
Nimesulide - 50 mg
Excipients: sucrose, sorbitol, methylparaben, propylparaben, xanthan gum, citric acid, quinoline yellow WS, pineapple flavor, polysorbate 80, glycerol, purified water.

Gel 20 g tube contains:
Nimesulide 10 mg/g, Methyl salicylate 100 mg/g, Menthol 50 mg/g, Capsaicin 0.25 mg/g
Other Ingredients: diethyl phthalate, diethylene glycol monoethyl ether, polyethoxylated hydrogenated castor oil, propylene glycol, sodium benzoate (E211), disodium edetate, butylated hydroxytoluene (E 321), carbomer, trometamol, purified water.

Nise tablets are a drug from the group of non-steroidal anti-inflammatory drugs. Its active substance is nimesulide, and therefore it has an anti-inflammatory and analgesic effect.

Unfortunately, many people believe that Nise is a pill for headaches and other pain, and take them as a regular painkiller, without following the dosage. As a result, the reviews about it are not very good: there are many side effects, the effectiveness is low. In fact, the medicine should be taken for diseases in the joints to reduce pain.

Available in both gel and tablets.

Components of the drug

The main component of the drug Nise is nimesulide (100 mg).

Also includes:

microcrystalline cellulose and sodium starch glycolate;
calcium hydrogen phosphate and corn starch.

In smaller quantities:

anhydrous colloidal silicon and purified talc;
Magnesium stearate.

The tablets are white, have a slight yellowish tint. They are smooth, round in shape and biconvex.

Nice is an excellent anti-inflammatory, antipyretic, antiplatelet and analgesic agent. Its main actions: suppression of prostaglandin synthesis directly at the site of inflammation, slowing down oxidative processes. If we take the description of the effect on the body, or rather, whether it causes addiction to itself, then we can say that the body does not get used to any of the components that are included in the composition.

The maximum amount of Nise in the blood can be determined 1.5 - 2.5 hours after administration.

The tablets must be stored in a dry place, out of direct sunlight and out of the reach of children. They are stored for a maximum of 3 years at an air temperature of less than 25 degrees.

For what diseases is it effective?

This medication is prescribed to drink for the following diseases of the stomach: ankylosing spondylitis, bursitis, tendinitis and tendovaginitis, osteoarthrosis and osteoarthritis, neuralgia, rheumatism and febrile syndrome. Due to nimesulide, which is included in the main composition, it is effective in inflammatory processes, post-traumatic pain and muscle pain, infectious diseases, myalgia.

Indications for use are: ankylosing spondylitis, arthritis (both rheumatoid and psoriatic).

Also prescribed for:

Widely used in dentistry, gynecology, and otolaryngology.

In gynecology, Nise tablets are prescribed for pain in the pelvic organs. They replace diclofenac, since it has lower hepatotoxicity, but at the same time has a better indicator of efficiency and speed of action. It is especially preferable after operations, when there is severe pain. Along with it, it is necessary to drink antibacterial drugs in order to provoke the body to develop various kinds of toxic reactions.

In what cases is it not prescribed?

Like many medications, Nise also has contraindications for use. So, tablets should not be taken in the following cases:

if hypersensitivity to any component, including nimesulide, has been detected;
a patient with bronchial asthma currently has a relapse of polyposis, an allergy to acetylsalicylic acid;
if there is erosion or ulcer of the gastrointestinal tract, cerebrovascular or other gastrointestinal bleeding;
any inflammatory diseases have worsened in the intestines;
blood clotting is impaired;
liver diseases;
heart or liver failure;
alcoholism, drug addiction;
hepatotoxic reactions to nimesulide;
hyperkalemia;
renal failure and other serious kidney diseases;
if coronary artery bypass surgery has recently been performed, that is, heart surgery;
there are contraindications for pregnant women, since the medication causes serious side effects, which can lead to miscarriage or fetal death;
if the child is under 12 years old.

Considering the listed contraindications for use, the doctor, however, can make an exception and prescribe Nice if there is:

coronary heart disease and congestive heart failure;
dyslipidemia/hyperlydemia; diabetes; peripheral arterial disease; suspicion of a gastrointestinal ulcer;
somatic diseases;
elderly age;
long-term use of NSAIDs;
taking antiplatelet agents, anticoagulants, oral corticosteroids, SSRIs.

The number of cigarettes smoked and alcohol intake are also taken into account.

Possible consequences of taking

Side effects from taking the pills are not very serious and are rare.

Self-medication, ignoring the instructions for use, allergies to the components that make up Nise (including nimesulide) - all this has consequences such as:

severe sensitivity to the drug, anaphylactoid reaction;
fear, headaches and dizziness, nervousness, drowsiness, Reye's syndrome;
increased sweating, rash and itching. Erythema and dermatitis, urticaria and angioedema, Stevens-Johnson syndrome and other exudative erythema, Lyell's syndrome are rare;
edema, dysuria and hematuria, hyperkalemia and urinary retention. Sometimes tablets can cause deficiency, oliguria, interstitial nephritis;
nausea and vomiting, diarrhea. Constipation, flatulence, gastritis, tarry stools and stomatitis, stomach ulcers, gastrointestinal bleeding are also possible;
the level of liver transaminases increases, as well as hepatitis, jaundice and cholestasis;
anemia and eosinophilia, thrombocytopenia and pancytopenia, purpura;
shortness of breath, exacerbation of bronchial asthma and bronchospasm;
blurred vision.

Very rarely, as a result of taking Nice tablets, there were reviews that general weakness or hypothermia appeared.

How to take it and in what doses

Nice adults need to take 1 tablet twice a day before meals, that is, the daily dose is 200 mg. If necessary, the doctor may prescribe 2 tablets of the medicine.

Directions for use: in 1 tsp. dissolve 1 tablet. Take before meals.

Children under 12 years old take Nise suspension, and from 12 years old - 1 tablet. 2 times a day. True, if a teenager weighs less than 40 kg, he should drink at a rate of 3-5 mg per 1 kg of body weight - this is to prevent an overdose and side effects.

Treatment lasts approximately 15 days.

Drug poisoning due to overdose

If the patient does not follow the instructions for using the medication Nice, he may experience an overdose. Then adverse reactions are clearly expressed. For example, gastrointestinal irritation, kidney dysfunction or liver failure, seizures or increased blood pressure. A person may suffer from severe headaches for several days.

If you suspect poisoning, you must stop taking these tablets, otherwise the condition will only worsen.

Reception by pregnant women

Taking nimesulide is contraindicated for pregnant women. It can seriously harm the health of both mother and child.

During breastfeeding, in extreme cases, the doctor may prescribe Nice, but in this case the baby is weaned.

Indications for the use of tablets with other medications are ambiguous. The effect of some of them is only enhanced due to the fact that Nice contains nimesulide, and in other cases, health only worsens.

Nimesulide enhances the effect on the body of drugs that reduce blood clotting.

Plasma lithium increases faster if lithium and nimesulide are taken simultaneously.

For example, nimesulide reduces the effect of furosemide on the body. In other cases, it can cause gastrointestinal bleeding.

The use of Nise and tablets with hydantoin and sulfanilamide is possible only under the supervision of a doctor, since it can give a negative result at any time.

Only in extreme cases can it be combined with:

So if you suffer from headaches and other pain that can be relieved with other tablets, then it is better not to take nimesulide.

If the medicine is prescribed for the treatment of gynecological diseases, then it is imperative to take antibacterial drugs along with Nice. However, over the past 10 years, no serious consequences have been observed in the practice of gynecologists.

Some more useful information

Sometimes not very positive reviews are left about the drug because the instructions for use were not carefully read, as well as side effects.

Tablets can sometimes cause drowsiness, and therefore their use by drivers while driving as a drug for headaches or any other pain is unacceptable. Even if Nice was prescribed by a doctor.

Also, Nise is not the best way to get rid of pain for people who need good reaction and speed of movement at work.

Elderly people should take the tablets with extreme caution.

The instructions indicate the exact composition of the medication, and therefore, if you are allergic to any of them, use is possible under the supervision of a doctor and only with his prescription.

If the joint pain or headaches are very severe, you should not take another additional pill - you can get poisoned and end up in the hospital.

People who have fully followed the instructions for using the drug are satisfied with the results of the treatment and leave positive reviews.