Fluconazole for thrush: principle of action of the drug, undesirable effects, contraindications. Instructions for use of fluconazole tablets - composition, indications, side effects, analogues and price

Fluconazole capsules 150 mg is a drug for the treatment of fungal diseases with the active ingredient fluconazole. Available in cylindrical hard gelatin capsules.

Due to its high fungicidal activity, reviews of Fluconazole 150 from doctors and patients who took it are positive. The effectiveness of the active substance of the drug capsule has been proven in a number of clinical trials.

During pregnancy, the use of fluconazole capsules should be avoided, except in severe cases of infection that threaten the woman's life, when the expected benefit of treatment for the mother outweighs the potential risk to the child.

Indications for use

1. Candidiasis of the mucous membranes, including thrush, oral cavity and pharynx, esophagus, non-invasive bronchopulmonary candidiasis, preventive measures to prevent relapses of oropharyngeal candidiasis in patients with HIV;
2. Generalized candidiasis, including candidemia, disseminated candidiasis and other forms of invasive candidal infections (infections of the peritoneum, endocardium, eyes, respiratory and urinary tract).
3. Cryptococcosis, including cryptococcal meningitis and other forms of this infection (including lungs, skin), both in patients with a normal immune response and in patients with various forms immunosuppression.
4. Mycoses (fungus) of the skin, including mycoses of the feet, body and groin area; pityriasis versicolor; onychomycosis; skin candidiasis; deep endemic mycoses, including coccidioidomycosis, paracoccidioidomycosis, sporotrichosis and histoplamosis in patients with normal immunity;
5. Prevention of fungal infections in patients malignant tumors against the background of radiation or chemotherapy, in patients with AIDS
6. Treatment and prevention of candidal balanitis, pityriasis versicolor and onychomycosis;
7. Fungal infection of feet, body, skin intimate areas And nail plates arms\legs.

Fluconazole 150 - use for thrush

How many days should I take fluconazole for thrush? For vaginal candidiasis and balanitis, adults are prescribed fluconazole capsules 150 mg once - that is, the norm is to drink once (one day). To prevent relapses of genital candidomycosis, use a dose of 150 mg once a month.

How long does it take for thrush to go away after fluconazole? Depends on severity fungal infection and timeliness of treatment started. In the “usual” case, the symptoms of thrush can go away within a week; according to patients, this period is from 5 to 15 days.

To prevent recurrence of fungal infection, the drug can be prescribed once a month at a dose of 150 mg. The duration of preventive therapy with fluconazole for thrush in women is determined individually and can range from 4 to 12 months.

How to take Fluconazole 150 for fungus?

Mycoses of the feet, groin, smooth skin, and skin candidiasis in adults are treated with fluconazole according to the following regimen: 1 capsule 150 mg per week for 2-4 weeks.
An alternative regimen for taking fluconazole for foot and skin fungus is possible according to the regimen: 1 capsule 50 mg daily.

For nail fungus, fluconazole is used according to the instructions - 150 mg once a week and therapy continues until the infected nail is completely replaced. It normally takes 3-6 months and 6-12 months for fingernails and toenails to re-grow, respectively.

Deep running forms Mycoses in children and adults are treated with a dosage of fluconazole not exceeding 400 mg per day. In this case, the period for how many days to take fluconazole is set strictly individually, depending on the course of the disease and the characteristics of the lesion.

When does fluconazole start working? The drug begins to act immediately, but you need to complete the entire course of treatment and wait for the nail to renew. Only in this case the risk of relapse will be minimized.

According to the instructions for use, fluconazole is allowed to be used to prevent fungal infection in patients with AIDS from the first day.

The dosage of fluconazole for children over 4 years of age should be calculated by a doctor and depends on the child’s weight. For candidiasis of the mucous membranes, the norm is 1–3 mg per kilogram of weight, and for systemic lesions it increases to 12 mg/kg.

Elderly patients, in the absence of renal impairment, should adhere to the usual (adult) dosage regimen of the drug. In patients with renal failure (creatinine clearance less than 50 ml/min), the dosage regimen should be adjusted.

Instructions for use Fluconazole 150, dosage

For adults with cryptococcal infections, the average dose of fluconazole is 400 mg 1 time / day on the first day of treatment, then 200 - 400 mg 1 time / day. The duration of treatment for cryptococcal infections is determined by clinical effectiveness, confirmed by mycological research, and averages 6-8 weeks.

For atrophic candidiasis of the oral mucosa, the use of 50 mg once a day is indicated. Treatment must be combined with treatment of dentures antiseptics. When treating other candidal infections of the oral mucosa, 50–100 mg per day is prescribed for a period of 14 to 30 days.

For coccidioidosis, the drug is used in a dosage of 200-400 mg/day. For the treatment of some forms of infections and the treatment of meningitis, the daily dose can be increased to 800 mg. Duration of treatment is 11-24 months.

For severe candidiasis of the mucous membranes - 100-200 mg per day. For the prevention of relapses of oropharyngeal candidiasis in patients with immunodeficiency, after completion of the full course primary therapy, the drug can be prescribed 150 mg once a week.

For balanitis caused by Candida fungi, fluconazole is prescribed orally as a single dose of 150 mg/day.

For pityriasis versicolor (varicolored) lichen, 2 capsules of 150 mg of fluconazole are prescribed once a week for a course of 2 weeks. In some cases, patients require the use of a 150 mg tablet in a double dose (2x150).

For children with candidiasis of the mucous membranes - 3 mg/kg/day once for at least 3 weeks; in the treatment of generalized candidiasis and cryptococcal infection (including meningitis) - 6-12 mg/kg/day for 10-12 weeks (up to laboratory confirmation absence of pathogens in the liquor).

Contraindications

• simultaneous administration terfenadine (against the background of constant use of fluconazole at a dose of 400 mg/day or more);
• simultaneous use of cisapride, astemizole;
• lactation period;
• children up to 6 years of age.

Should be taken with caution in case of renal and liver failure, consultation with a doctor is required!

Repeated use of fluconazole during pregnancy and exceeding the dose of the drug cause developmental abnormalities in newborns.

If rash occurs in patients with invasive/systemic fungal infections, they should be monitored closely and fluconazole should be discontinued if bullous lesions or erythema multiforme develop.

Concomitant use of fluconazole and hydrochlorothiazide can lead to an increase in fluconazole concentrations by 40%.

Side effects

Fluconazole is usually well tolerated, but side effects:

• nausea;
• internal discomfort;
• constipation or diarrhea;
• disruption of enzymatic formation in liver cells;
• headache;
• cramps and spasms of the calf muscles;
• may be noted in blood tests sharp drop platelet and leukocyte levels;
• arrhythmia;
• hives.

IN in rare cases possible manifestation of anaphylactic shock.

Overdose

Symptoms: hallucinations, paranoid behavior, nausea, vomiting, diarrhea, severe cases– convulsions.
Appointed symptomatic treatment with gastric and intestinal lavage.

Analogues of Fluconazole 150, price and list of drugs

Similar drugs: Diflucan, Medoflucon, Fluzon.
The selection of analogues and dosages should be made by a doctor!

Be careful, the instructions for use of Fluconazole and reviews of analogues are not suitable and cannot be used as a guide for their use. When replacing the drug, consult a doctor and read the instructions.

Price in Russian pharmacies: Fluconazole 150 mg N1 capsule - from 8 to 19 rubles.

Conditions and shelf life
Store in a dry place, protected from light and out of reach of children, at a temperature not exceeding 25 °C.

Part drug in capsule form active ingredient included fluconazole . The capsules also contain additional components: low molecular weight potato starch, calcium stearate or magnesium stearate.

Fluconazole tablets contains a similar active ingredient, as well as sodium lauryl sulfate as an additional component.

Release form

This medicine is available in Fluconazole capsules 150 mg, 50 mg, 100 mg. These are capsules blue color, contains white or yellowish granular powder inside. Contained in blister packs, which are placed in cardboard boxes. Fluconazole tablets, syrup, gel, suppositories, and solution for intravenous administration of Fluconazole are also produced.

pharmachologic effect

The abstract contains information that the drug acts as an antifungal agent, inhibiting specifically the synthesis fungal sterols . Belongs to class triazole compounds .

There is a specific effect on fungal enzymes, which depend on cytochrome P450 . The active substance demonstrates activity against a variety of strains Candida spp.(including effective against visceral candidiasis), Cryptococcus neoformans(including effective against intracranial infections), Trichophytum spp., Microsporum spp.. The drug is also active against microorganisms that are causative agents of endemic mycoses: Coccidioides immitis, Hystoplasma capsulatum, Blastomyces dermatitidis.

The remedy stops the transformation into ergosterol lanosterol fungal cells. Under its influence, the permeability of the cell membrane increases, the process of its growth and replication is inhibited. It is highly selective for cytochrome P450 of fungi, but in the human body it almost does not inhibit these enzymes. Does not demonstrate antiandrogenic activity.

Pharmacokinetics and pharmacodynamics

Wikipedia indicates that after oral administration the drug is actively absorbed into the human gastrointestinal tract. In plasma, the concentration of the active substance is more than 90% of the level that is observed if intravenous administration is practiced. The absorption of the substance is not affected by food intake, so it does not matter how you take it, before or after meals. After taking the medicine orally, the highest concentration in the blood occurs after 0.5–1.5 hours. The half-life from the blood is 30 hours. That is, you can take the product once a day. At vaginal candidiasis A single dose of the drug is sufficient, for which one tablet or another form of the drug is used.

11–12% of the active substance binds to blood plasma proteins. When the drug begins to work depends on the treatment regimen. If you take the medicine once daily, then a stable concentration of the active component in the human blood is observed on the fourth or fifth day (in 90% of people). If on the first day of treatment the patient is administered a double dose daily dose, then this effect is observed already on the second day of treatment.

Penetrates into all fluids in the body. It is excreted from the body through the kidneys, approximately 80% is excreted unchanged.

Indications for use

The following indications for use of the drug are determined:

• infectious diseases caused by candida (disseminated candidiasis, generalized candidiasis, other forms of invasive candidiasis;
• mucous membranes (including pharynx, oral cavity, esophagus);
• candiduria ;
• chronic atrophic and mucocutaneous candidiasis of the oral cavity (develops in people with dentures);
• non-invasive bronchopulmonary infections ;
• genital candidiasis (vaginal candidiasis in acute form and with relapses);
• prevention of recurrent manifestations of vaginal candidiasis (if the disease develops three times a year), candidal balanitis ;
• cryptococcal infection, cryptococcal meningitis ;
• ringworm (including mycoses of the body, feet, groin area);
• endemic mycoses deep ;
• development prevention fungal infections in people who have undergone cytostatic or radiation therapy.

Contraindications

There are the following contraindications for the use of this medicine:

• manifestation of high sensitivity to fluconazole or azole compounds, which chemical structure close to fluconazole;
• parallel use if the patient receives a dose of Fluconazole 400 mg per day or more;
• parallel reception astemizole any other medications that increase the QT interval;
• age up to 4 years.

Should be taken with caution in case of liver failure, also renal failure, when a rash appears in people suffering from a superficial fungal infection, in potentially proarrhythmogenic conditions in people with risk factors (organic heart disease, taking medications that provoke the development , electrolyte imbalance). How to take Fluconazole in this case, you should definitely ask a specialist.

Side effects

When treated with the drug, the patient may develop the following side effects:

• abdominal pain, diarrhea ;
• headache;
• nausea , ;
• skin rash;
• hepatotoxic effects;
• anaphylactic reactions.

How to take the medicine when such effects occur, and whether it is worth continuing treatment, should be individually consulted with a doctor.

Instructions for use of Fluconazole (Method and dosage)

The drug is prescribed for oral administration (capsules Fluconazole Stada, Fluconazole Teva, tablets) or for use by intravenous administration. There are also other forms of medication, the active ingredient of which is fluconazole - suppositories, ointment.

The solution is infused at a rate not exceeding 10 ml per minute.

Fluconazole tablets, instructions for use

The dosage of the drug depends on the disease and its severity.

Patients with disseminated candidiasis, candidemia on the first day, 400 mg is prescribed, then the dose should be reduced to 200 mg. Children for treatment purposes generalized candidiasis A dose of 6–12 mg per 1 kg of weight per day is indicated.

Patients with oropharyngeal candidiasis 50 mg to 100 mg of Fluconazole is indicated once a day, the treatment period is 1-2 weeks.

To people suffering atrophic candidiasis of the oral mucosa , indicated at 50 mg once a day. Treatment is combined with the use local funds for processing dentures. When treating other candidiasis infections of the mucous membranes, 50–100 mg per day is prescribed, the period of therapy is from 14 to 30 days.

In order to prevent the development of relapses oropharyngeal candidiasis in people with 150 mg once a week is indicated. If mucosal candidiasis develops in children, the dose should be taken at the rate of 3 mg of drugs per 1 kg of weight per day. On the first day, you can give your child a double dose.

Patients with cryptococcal infections and cryptococcal meningitis , as a rule, 200–400 mg of drugs are prescribed once a day. On the first day, 400 mg of the drug is indicated. The duration of treatment can be from 6 to 8 weeks. Children are prescribed a dose of 6–12 mg per 1 kg of weight per day.

To people suffering infectious skin diseases , it is recommended to prescribe 150 mg once a week or drink 50 mg of the drug once a day. Treatment should be continued for 2-4 weeks. For men and women, sick mycosis of the feet , sometimes longer therapy is required - up to 6 weeks.

Patients with pityriasis versicolor It is recommended to take 300 mg once a week, the treatment period is 2 weeks. Depending on the intensity of your symptoms, your doctor may prescribe another dose of Fluconazole in the third week. It is possible to use another treatment regimen - 50 mg 1 time per day, the treatment period is two to four weeks.

Sick onychomycosis Prescribe 150 mg once a week. Therapy should continue until a healthy nail grows in place of the diseased nail.

People suffering deep endemic mycosis , sometimes undergo a long course of treatment with the drug, which can last up to two years. The dose per day is 200–400 mg.

The instructions for the use of fluconazole provide that for vaginal candidiasis, a single dose of the drug is taken, its dose is 150 mg.

As a rule, Fluconazole for thrush is effective after a single dose. But your doctor will tell you more about how to take Fluconazole for thrush after an individual consultation. Before determining how to take any medicine for thrush if you have thrush, the specialist takes into account the causes of the disease and individual characteristics its flow. For chronic thrush, Fluconazole Teva or other types of the drug are prescribed to prevent relapses at a dose of 150 mg once a month. The product should be used for 4-12 months. For the purpose of prevention, capsules are prescribed in a dose of 50–400 mg once a day, depending on how high the risk of the disease is. For children with thrush, Fluconazole tablets are prescribed at a dose of 3–12 mg of medication per 1 kg of weight per day. How much to drink depends on the severity of the infection.

If Fluconazole and Zidovudine , the patient should be monitored by a doctor, as the side effects of Zidovudine may increase.

If treatment is prescribed at the same time Astemizole , Cisapride , Tacrolimus , or any other drug that is metabolized by the cytochrome P450 system, an increase in the concentration of these drugs in the blood is possible.

The absorption of Fluconazole is not affected by simultaneous administration or antacids.

Terms of sale

They are sold in pharmacies by prescription; a specialist gives the prescription in Latin.

Storage conditions

Fluconazole suppositories, Fluconazole ointment, cream, tablets and capsules should be stored in a dark place, drugs should be protected from direct sunlight.

Best before date

special instructions

If liver dysfunction is observed during treatment, constant monitoring by a physician is important. If signs of liver damage are observed, the medication should be discontinued.

When using the medicine topically for men and women, it should be taken into account that people with AIDS are more likely to develop a variety of skin reactions.

It is necessary to take into account not only how long it takes for Fluconazole to act, but also the fact that if treatment is stopped prematurely, relapses may develop. Therefore, it is important to completely complete the prescribed treatment regimen. It is important to take this into account when using Fluconazole for nail fungus, since reviews for nail fungus indicate that if treatment is stopped prematurely, a relapse of the disease may occur.

Many patients have a question about whether Fluconazole is an antibiotic or not? Please note that this is an antifungal agent, not an antibiotic.

Whether men can take this drug depends on the diagnosis. Fluconazole for men is prescribed for fungal infections; it must be taken exactly as prescribed.

Fluconazole analogs

Level 4 ATX code matches:

Fluconazole analogues are products with a similar active ingredient. The price of analogues depends on the manufacturer and the form of release of the drug. There are a number of analogues of this drug: Diflucan , Vero-Fluconazole , Flucostat , Fluconazole Tiva ,Fluconazole Stada and etc.

Which is better: Fluconazole or Diflucan?

Often patients compare two drugs with antifungal effect— Fluconazole and . What is the difference between these medicines? Both drugs are based on the active substance fluconazole. Diflucan is available in tablets of 50 mg, 100 mg, 150 mg, and other forms. But the price of Diflucan is much higher.

Flucostat or Fluconazole - which is better?

Talking about what's different Flucostat from Fluconazole, it should be noted that both drugs contain the same active substance. Flucostat is a more expensive medicine. What is the difference between these medications, and which one is best prescribed in a particular case, is determined by a specialist. As a rule, Fluconazole is more often prescribed when prophylaxis is necessary for cancer patients after radiation and chemotherapy.

Fluconazole or Nystatin - which is better?

- This antifungal drug, an antibiotic active against Candida bacteria. Under the influence of Nystatin, the permeability of the membrane of fungal cells is disrupted, which contributes to disruption of their growth and reproduction. Which drug is preferred in a particular case depends on the diagnosis and the doctor’s prescription.

For children

The instructions indicate that the drug is prescribed to children after they reach 5 years of age. Dosage for children is determined depending on the disease. As a rule, it is determined at the rate of 6-12 mg per 1 kg of child weight. For children under 5 years of age, the medicine is prescribed strictly according to indications and under the supervision of a specialist.

Fluconazole and alcohol

When discussing Fluconazole's compatibility with alcohol, doctors do not recommend drinking alcohol during treatment. This combination is very dangerous for the liver. In addition, alcohol during treatment can provoke the development of unpleasant side effects from the gastrointestinal tract, blood vessels, and heart.

Fluconazole during pregnancy and lactation

Fluconazole is rarely prescribed during pregnancy, especially in the 1st trimester and 2nd trimester. The only exceptions are those cases when a woman is diagnosed with severe fungal infection. During lactation, the drug is not prescribed, as the substance passes into breast milk.

Reviews about Fluconazole

Due to the high fungicidal activity of this drug, patient reviews and doctors' reviews of Fluconazole are mostly positive. Patients leaving reviews about Fluconazole Teva, as well as reviews about Fluconazole Stada on the forums, they write that the drug helps to quickly and effectively eliminate the symptoms of fungal diseases. Users mention that the tablets are relatively inexpensive, but at the same time they allow you to completely get rid of nail fungus and other unpleasant diseases. In some cases, it is enough to take Fluconazole 150 mg once to completely overcome the symptoms of the disease.

Very often women write positive reviews about Fluconazole for thrush . It is noted that the medicine not only relieves thrush, but also helps prevent relapses of the disease.

Fluconazole price, where to buy

The price of Fluconazole tablets depends on the packaging and manufacturer. You can buy Fluconazole in Moscow at prices ranging from 20 to 170 rubles. Capsules 150 mg (1 piece in a package) can be bought for an average of 30 rubles. Capsules 50 mg can be purchased at a price of 30 rubles (7 pcs in a package). The cost of the drug Fluconazole Teva 150 mg is 150-170 rubles per pack. (1 PC.).

The price of Fluconazole in Ukraine (Odessa, Kyiv, etc.) is 17-20 hryvnia (100 mg capsules, 7 pcs.). The price of Fluconazole 150 mg in Kharkov, Zaporozhye, Dnepropetrovsk, etc. is an average of 10 hryvnia (1 piece per package). 150 mg tablets can be bought in Ukraine for an average of 20 hryvnia.

How much tablets for thrush cost in Kazakhstan and Belarus depends on the packaging and manufacturer. In Minsk, you can buy 150 mg capsules for 10,000 – 103,000 rubles, depending on the number of tablets in the package.

How much other forms of release of the drug with fluconazole (suppositories, ointment, cream) cost also depends on the manufacturer.

• Online pharmacies in Russia Russia
• Online pharmacies in Ukraine Ukraine
• Online pharmacies in Kazakhstan Kazakhstan

WER.RU

Fluconazole-Teva capsules 150 mg Teva [Teva]

Ozone LLC

Fluconazole capsules 150 mg 2 pcs.Health - pharmaceutical company

Fluconazole STADA capsules 150 mgSalutas Pharma [Salutas Pharma]

Fluconazole capsules 150 mg Vertex

Europharm * 4% discount using promo code medside11

Fluconazole-Vertex 150 mg 2 capsPharmaceutical company "Zdoro"

Fluconazole-teva 150 mg 1 capsTeva Private Co. Ltd Pharmaceutical

Genital candidiasis is inflammatory process caused by reproduction yeast fungus genus Candida. A number of factors contribute to the proliferation of this type of fungus and the appearance unpleasant disease, from which women, men and children suffer is thrush (candidiasis). One of the most effective drugs against thrush is Fluconazole. This drug shows top scores in the fight against genital candidiasis. Fluconazole is an antifungal drug with powerful therapeutic effect in relation not only to thrush pathogens, but also to some types of lichen and dandruff.

The use of Fluconazole for thrush and its types of disease

Dosage form of Fluconazole:

• Syrup, suspension for oral administration.
• Intravenous solution, capsules, powders.
• Pills

Fluconazole is used for:

• Mycoses of the skin.
• For genital candidiasis (forms: acute, generalized, chronic, recurrent).
• Candidiasis of the mucous walls.
• Deep endemic mycosis, cryptococcosis.
• Prevention goals.

Treatment of thrush with Fluconazole

The pharmaceutical industry produces a sufficient number of drugs against thrush. Active ingredient Most of these drugs are Fluconazole. This drug is effective both for thrush and for systemic candidiasis, skin mycoses, candidiasis of the mucous membranes, sporotrichosis and coccidioidomycosis. Fluconazole – domestic drug affordable.

The first thing you need to do at the first signs of thrush is to visit a doctor, undergo comprehensive examination and confirm the diagnosis.

Taking Fluconazole:

• If thrush is diagnosed for the first time (fresh episode), then a single dose of the drug at a dosage of 150 mg is sufficient. After a few days, you need to take another Fluconazole capsule. Sometimes the doctor supplements the therapy vaginal suppositories, creams or ointments for local application.
• Taking the drug does not depend on food intake.
• Fluconazole can be taken with any amount of water.
• Treatment is carried out on both regular sexual partners. The dosage for men is the same as for women.
• During treatment, it is advisable to abstain from sexual intercourse.

Reception for chronic thrush:

• Take 150 mg twice. The interval between doses is 3 days. After this, the drug is prescribed on the first day menstrual cycle 150 mg for six months or a year. The prescription is regulated by the doctor based on the course of the disease.
• It is prohibited to drink alcohol during treatment with Fluconazole.
• Most effective treatment Fluconazole includes complex therapy(douching, antifungal suppositories, taking anti-inflammatory drugs).

Useful information about the drug

Check with your doctor before taking Fluconazole

Need to know:

• The fluconazole treatment regimen is determined by the doctor according to the severity and severity of the disease, as well as taking into account the presence of sexually transmitted infections.
• Fluconazole is generally well tolerated, but in 15% of cases there are complaints of violation gastrointestinal tract And allergic reactions.
• Fluconazole should not be taken during pregnancy and lactation.
• The drug is contraindicated in children under 4 years of age.
• Do not take if you are hypersensitive to the components of the drug.
• Do not take simultaneously with Astemizole and Terfinadine.
• Take the drug with caution in case of liver and kidney failure, electrolyte imbalance and organic heart disease.

Analogs of Fluconazole include: Diflunol, Flunol, Flucostat.

Fluconazole is a drug that is distributed to pharmaceutical market. Its therapeutic effect allows it to be used for various fungal infections.

What does the drug consist of?

The main active ingredient is the substance of the same name. From excipients highlight the presence of starch, polyvinylpyrrolidone, and magnesium stearate in the composition.

Fluconazole is available in several dosage forms. Dosage from 50 to 150 mg.

Impact on the body

The drug, like everything else, belongs to the group of antifungal agents. This highly specific effect is due to inhibition of enzyme production. By blocking the conversion of lenosterol to another component of its membrane, the permeability of the cell wall increases. As a result, the growth and replication processes of the fungus are disrupted.

The high specificity is explained by the fact that when used, cytochrome p450 is not inhibited in the human body; in the fungus it is blocked. Antiandrogenic activity does not develop.

It shows its activity against a large number of groups of fungi, in particular the genus Candida.

It is applied orally, after use for a short time, complete absorption is recorded. The level of bioavailability reaches 90%. Food does not affect the level of absorption of the substance.

After 30 minutes or an hour from the moment of use, it is revealed maximum concentration in blood serum. The concentration will depend on the volume of the product. The percentage of protein binding is low.

The drug penetrates the histo-hematological barriers. Concentration in breast milk cerebrospinal fluid or saliva is equal to that in the blood. The product has no metabolites.

Excretion is carried out through the kidneys, to a lesser extent occurs unchanged. The average period during which up to half of the total concentration is released is 30 hours. Hemodialysis can remove up to half the concentration. Pharmacokinetic data determines the time it takes for the disease to pass.

Why and when to take Fluconazole

The use of Fluconazole for thrush is quite common. It is prescribed when the pathogen is localized in certain parts, including during a generalized process.

Most often, the use of fluconazole for thrush in women is indicated in cases of damage to the genital tract, including those with a chronic type of course. The drug fights the symptoms of the disease: itching, painful sensations, curdled discharge.

Dosage instructions

Instructions for use for thrush do not cause difficulties; it describes in detail information on how to take the drug. Inflammation localized in the female reproductive system requires the use of 150 mg of the substance.

For achievement therapeutic effect A single dose of the capsule is sufficient. This dosage It is also prescribed for thrush in the urogenital tract in men.

Fluconazole 150 mg is prescribed for thrush once a week for persons suffering from an immunodeficiency state associated with HIV infection.

Recurrent involves the use of 150 mg monthly. The duration of treatment is one year.

For persons childhood the dosage varies depending on body weight. For 1 kg use 6-12 mg. The instructions apply to thrush that has an acute course.

When the product is prohibited from use

The product should not be used by patients with:

• availability hypersensitivity to any component included in the composition;
• combination of the drug with terfenadine, when consumed daily more than 400 mg;
• the use of drugs that cause prolongation of the QT interval during heart contractions. These include a large number of drugs, for example, Astemizole;
• The patient is less than 4 years old.

Particular caution should be exercised when used by patients diagnosed with renal or liver failure, as well as rashes on the surface skin, which have an unclear etiology.

Side effects

Use of the product against the background of hypersensitivity to components or excess permissible dosage leads to the development of side effects.

These include:

• abdominal pain, diarrhea;
• headache;
• nausea and flatulence clinic;
• the appearance of rashes on the surface of the skin that are polymorphic in nature;
• development of hepatotoxic effect;
• anaphylactic shock.

In order to avoid the development of such conditions, it is necessary to consult a specialist. It will help eliminate complications and also determine how much of the drug is safe for the patient to drink.

The development of an overdose can occur even if the average daily therapeutic volume is slightly exceeded. The most typical manifestations include nausea, diarrhea or vomiting. Rarely occur severe symptoms in the form of a convulsive syndrome.

For elimination similar condition procedures of forced diuresis, gastric lavage, and hemodialysis are carried out.

Rules for combination with other means

If you combine the drug with hydrochlorothiazide, the concentration of Fluconazole increases several times.

Concomitant use with hypoglycemic agents by oral means The half-life of Fluconazole increases, and the risk of developing a hypoglycemic state increases. Antacids in combination with the drug do not change absorption.

It is prohibited to use the product simultaneously with alcoholic products. This is due to increased toxic effects on the liver. When combined, the development of disturbances in the functioning of the cardiovascular and hepatobiliary systems is possible.

Features of use during pregnancy and breastfeeding

The use of Fluconazole for thrush during pregnancy is not contraindicated. Caution is exercised during the first and second trimester. During breastfeeding use prohibited.

Treatment involves limiting the baby's feeding breast milk until the substance is eliminated from the body.

Purchase and storage rules

Fluconazole is purchased from pharmacy chain with a prescription from a specialist. Acceptable deadlines Storage: shelf life is 3 years from the date of issue.

Candidiasis (popularly known as thrush) is a disease of the genital organs, which is provoked by yeast-like fungi of the genus Candida, which develop in excessive quantities. The disease got its name because it is accompanied by plaque white on the genitals and discharge that has a cheesy consistency. Doctors often prescribe Fluconazole for thrush; read about this in detail later in the article.

Fluconazole for thrush is considered one of the most effective medicines that help overcome this disease. This is why doctors prescribe this drug more often. The drug has a wide antifungal spectrum of action and gives good result, suppressing vital activity pathogenic microorganisms. The drug has proven itself well as a treatment infectious diseases which are caused by yeast fungi.

Fluconazole for thrush for men and women is available in the following forms:

• capsules;
• pills;
• solution for injection, infusion.

The price of Fluconazole produced in Russia ranges from 18 to 49 rubles (depending on the form of release). For example, capsules with a dosage of 150 mg will cost more, and a solution for infusion will be cheaper.

Directions for use for thrush

How to take the drug correctly is described in detail in the instructions that come with it. In addition, when prescribing treatment, the doctor must tell you how to use this or that form of medication. Let's take a closer look at this.

Pills

If the disease is detected for the first time, then sufficient treatment is a single dose of tablets, the dosage of which is 150 mg. To consolidate the result, after a week or two you need to take another tablet in the same dosage.

Fluconazole tablets for thrush will help get rid of chronic form diseases. In this case, the dosage is prescribed by the doctor. Basically, the following dosage regimen is recommended for the patient: 150 mg every 3 days for 14 days. After which therapy lasts another 6 months, and one tablet of Fluconazole should be taken every 30 days to prevent relapses.

If candidiasis develops due to taking antibiotics, the drug in tablet form is taken once.

In any case, the tablets should be taken after meals and washed down with 1/2 glass of water. It should be noted that the drug does not negatively affect the intestinal microflora after short-term use. If therapy is long-term, then Fluconazole is recommended to be combined with the intake of natural probiotics.

If a girl or woman is undergoing treatment for candidiasis, then it is better to take the pill on the first day of menstruation. Men can start treatment at any time.

Capsules

Capsules are prescribed for all types of thrush, as well as prophylactic drug, preventing development of this disease in people suffering from AIDS.

The dosage of Fluconazole in capsules is the same as for tablets. If the patient has developed a relapse, then it is necessary to immediately consult a doctor. In this case, the course of therapy is mainly extended, and the specialist may also decide to supplement systemic treatment local in the form of ointments or suppositories with active substance fluconazole. Acute form candidiasis is treated from 5 to 10 days, chronic - 14 days.

Fluconazole and pregnancy

If a woman who is carrying a child suffers from thrush, then the use of Fluconazole is unacceptable. Therapy with this drug is possible only if the benefit to the mother is several times greater than the harm that can be caused to the fetus. Statistics show that pregnant women who treated candidiasis with Fluconazole for 3 months gave birth to children with birth defects in development.

Contraindications

Before using Fluconazole, it is imperative to familiarize yourself with the prohibitions regarding its use. This will help avoid unwanted consequences. The main prohibitions for use are the following conditions and diseases:

• individual immunity to any component of the drug;
• drug therapy Terfenadine and Cisapride. The combination of the above medicines with Fluconazole is strictly prohibited;
• breast-feeding.

Relative contraindications for use are as follows:

• liver and kidney failure;
• age under 18 and over 65;
• heart rhythm disturbances;
• long QT syndrome.

Side effects

Treatment of thrush with Fluconazole may cause the development of unwanted reactions in the body. Patients should be aware of these manifestations. Let's take a look at the possible side effects when treating candidiasis with Fluconazole:

• from the gastrointestinal tract: constipation or diarrhea, bloating, sometimes painful sensations in the epigastrium, aversion to food occurs frequent urge to vomiting;
• from the outside nervous system: weakness, lack of coordination of movement, migraine-like conditions, rarely - spontaneous muscle contractions;
• from the outside hematopoietic system- thrombocytopenia, leukopenia, neutropenia, agranulocytosis;
• allergic manifestations - urticaria, erythema, Lyell's syndrome;
• the drug Fluconazole can provoke a deterioration in kidney function, reduce the amount of potassium in the body, indicator bad cholesterol- increase.

Analogs

If necessary, the drug Fluconazole can be replaced with analogue drugs. Only the attending doctor does this. To medicines, active component which fluconazole is, include the following:

• Diflucan;
• Flucostat;
• Mycomax;
• Funzol;
• Futsis;
• Mikosist.

Final advice: Do not under any circumstances diagnose yourself, much less self-medicate. Only a specialist can determine whether there is candidiasis. For this purpose, a special analysis of a smear of the vaginal microflora is carried out, which prevents many errors in therapy. Only a doctor, taking into account the health status of each patient and test results, will be able to prescribe the correct effective treatment that will not provoke undesirable consequences for the body.

What is thrush

Many people think that thrush is transmitted exclusively through sexual contact. However, this is not quite true. Let's take a look at the most common causes of the disease:

• violation normal microflora vagina (dysbiosis, or dysbacteriosis);
• uncontrolled treatment with antibiotic drugs;
• changes of any nature concerning hormonal levels body (use contraception, menstrual irregularities);
• condition that occurs after surgical interventions;
• wearing underwear that fits tightly to the body (for example, thongs);
• failure to comply with personal hygiene rules;
• decreased immunity;
• diseases that are transmitted through sexual contact.

The danger of thrush is that quite often it disguises other dangerous and difficult-to-treat infections that develop against the background of candidiasis. The disease can occur in both women and men.

Symptoms

Symptoms of the disease manifest themselves differently in each woman. It all depends on the state of immunity and the presence concomitant diseases. The main symptoms of the disease include the following:

• severe itching and burning in the genital area;
• discharge that has a cheesy consistency, exuberant character and sour smell;
• pain during urination, as well as during sexual intercourse.