home Auditorium 8 Which is better, Ferrum Lek tablets or injections? "Ferrum Lek" during pregnancy. The drug "Ferrum Lek": instructions, indications, side effects

Which is better, Ferrum Lek tablets or injections? "Ferrum Lek" during pregnancy. The drug "Ferrum Lek": instructions, indications, side effects

Pregnancy is often accompanied by anemia. In this condition, there are not enough healthy red cells in the blood to deliver oxygen to the tissues of the mother and baby.

During pregnancy, more blood cells are produced to support the baby's development. If the mother's body does not receive enough iron or some other nutrients, hematopoietic organs unable to produce enough red cells. The result is anemia. One of the drugs for its treatment is Ferrum Lek. During pregnancy, even a short course of injections of this drug is enough.

Classification

Anemia has three degrees of severity, which depend on the number of red blood cells and hemoglobin in the blood. This condition develops due to a lack of microelements or vitamins. Anemia can be of the following types:

folate deficiency;
iron deficiency;
caused by vitamin B12 deficiency.

The most common anemia during pregnancy is iron deficiency. With this type, the amount of hemoglobin, which transports oxygen from the lungs to all cells of the body, is reduced.

Consequences

Flaw folic acid and vitamin B12 can lead to congenital defects development, premature birth and to fetal growth restriction syndrome. During childbirth, due to anemia, there is a high chance of developing weakness during labor. In addition, the following complications may occur:

birth of a premature or low birth weight baby;
loss of a significant amount of blood during childbirth, which requires transfusion of blood components;
postpartum depression;
birth of a child with anemia.

Predisposing factors

The risk of anemia during pregnancy increases if:

All this is taken into account by the doctor when monitoring a pregnant woman. In this case, correctly prescribed treatment allows you to avoid various consequences.

Symptoms

The most common during pregnancy are:

pallor of mucous membranes, skin, lips and nails;
feeling tired or weak;
dizziness;
dyspnea;
heartbeat;
problems with concentration.

On early stages Anemia may not have obvious symptoms. And many of them are characteristic of a normal pregnancy. To get it right and adequate treatment, required to pass clinical analysis blood, and, if necessary, hematocrit and blood test for iron ions.

When is Ferrum Lek prescribed?

Used to treat anemia. Today there is big choice these medicines. Many doctors prefer to prescribe Ferrum Lek during pregnancy. This is explained by many of his positive properties. In addition, convenient forms of release of Ferrum Lek have been developed: injections (solution for intravenous and intramuscular injections), chewable tablets and syrup.

A child who is born from a mother with anemia also lacks iron ions. This component is not added during breastfeeding. Anemic mothers most often have a small amount of milk, and the iron content in it is insufficient.

It may not appear in children, but during adolescence adolescents exhibit symptoms of anemia. Quite often these children meet with frequent colds, and some developmental delay. Because of this, it is necessary to carry out complex treatment anemia for expectant mothers. In addition to a diet rich in iron and protein, it is necessary to add vitamins and iron-containing products, which include the drug Ferrum Lek.

Action of the medicine

The peculiarity of the composition of the drug - the combination of iron ions with polymaltose - determines its effect. This complex is similar to iron-storing protein. Therefore, the main component of the drug “Ferrum Lek” during pregnancy does not lead to darkening of tooth enamel and is well absorbed by the body.

Many people believe that it is only possible through food. The diet should indeed be rich in iron-containing foods and proteins. But you need to know that food products differ different levels absorption of an element such as Fe. For example, in meat its amount is 40-50%, and for products plant origin this figure generally does not exceed 3-5%.

Iron absorption is reduced due to the use of tannin (coffee, tea), phytins (salt), phosphates (seafood, River fish). For the same reason, it is not recommended to take medications with tea. The use of Ferrum Lek with various medications - antacids, tetracyclines, magnesium and calcium salts - during pregnancy will not raise hemoglobin to the required level.

Upon appointment medicines For pregnant women, the obstetrician takes into account many factors. The main requirements are: good tolerability, high percentage of absorption in the body and safety of use. The drug "Ferrum Lek" (injections, tablets and syrup) has established itself as a medicine that meets all the necessary indicators.

Efficiency

In terms of its effectiveness, it is similar to ferrous iron products, but it is safer and does not allow complications after an overdose. "Ferum Lek" syrup, as well as other forms of the drug, are characterized by fairly high tolerability. This drug is not inactivated by various food components. For this reason, taking it with meals does not reduce the absorption of iron.

Cases of irritant effects gastrointestinal tract rare. The use of Ferrum Lek during pregnancy makes it possible to achieve a gradual improvement in laboratory and clinical signs iron deficiency. These include weakness, tachycardia, dry skin, dizziness and increased fatigue.

Forms of medicine

The drug is presented in different forms: chewable tablets, injections and syrup. The duration of treatment and dosage are determined general condition pregnant woman, hemoglobin level, red blood cell count and hematocrit. Most often, 3 tablets or syrup in an amount of 20-30 ml are prescribed daily. The course continues until the hemoglobin level rises to 110 g/l. This is monitored by blood tests. In most cases, 10-14 days are sufficient. Subsequently, the dosage is reduced to 1 tablet or 10 ml of syrup once. The drug is most often prescribed after meals. “Ferrum Lek” (syrup) is recommended to be added to water or drinks, and the tablets need to be dissolved or chewed.

At adequate therapy effective antenatal prevention of iron deficiency for mother and fetus and prevention of various complications is guaranteed.

Studies confirm the safety of the drug, but it can only be prescribed by a doctor after test results. Self-medication with Ferrum Lek (syrup or tablets) is excluded. This can affect the mother's body and the condition of the fetus.

Pharmacokinetics

Iron enters the blood plasma quite quickly: 10% of the dose - after 10 minutes, 45% - after 30 minutes. Biological time half-life is 3-4 days. Iron with transferrin is used to produce enzymes, hemoglobin, myoglobin. The complex with dextran is not excreted through the kidneys, as it has a large molecular weight.

Contraindications

The drug is contraindicated in the first 12-13 weeks of pregnancy. Obstetricians, based on their experience, prescribe the drug in the second and third trimesters and during breastfeeding, but under the control of the condition of the fetus or newborn.

The use of the drug is contraindicated for:

Prescribe the drug with caution when bronchial asthma, chronic polyarthritis, insufficient iron-binding capacity of hemoglobin, lack of folic acid, children under 4 months.

Side effects

From negative effects The following should be noted:

Rarely possible allergic reactions. Incorrect injection technique can lead to pain, swelling and inflammation at the injection site.

Method of use and dosage

Before the first injection, each woman must be given a test dose, which is 25-50 mg of iron for adults and half the dose for children. Absence local reactions for 15 minutes indicates good tolerability.

"Ferrum Lek": price

Tablets of this drug in Russia can be purchased at a price from 200 to 400 rubles. The cost of syrup is 150 rubles. As for the Ferrum Lek ampoule solution, its price is quite high - from 800 to 1300 rubles. But it should be remembered that the effect of taking the drug justifies high cost"Ferrum Lek". The price (tablets, syrup or ampoules) is quite reasonable. And most importantly, all this will undoubtedly benefit all pregnant women suffering from anemia.

INSTRUCTIONS
By medical use medicinal product

Read these instructions carefully before you start using this medicine.
Save the instructions, you may need them again. If you have any questions, consult your doctor. This medicine is prescribed for you personally and should not be given to others because it may harm them even if they have the same symptoms as you.

Registration number:

Trade name of the drug:

Ferrum Lek ®.

International nonproprietary name or generic name:

iron (III) hydroxide polymaltosate.

Dosage form

Chewable tablets.

Compound

1 chewable tablet contains:
Active substance: iron (III) hydroxide polymaltosate 400 mg, in terms of iron – 100 mg.
Excipients: macrogol 6000 – 37.0 mg; aspartame – 1.5 mg; chocolate flavoring – 0.6 mg; talc – 21.0 mg; dextrates – until 730.0 mg is obtained.

Description

Round flat tablets dark brown interspersed with light brown color, with a chamfer.

Pharmacotherapeutic group

Antianemic agent. Iron supplement.

ATX code: В03АВ05.

Pharmacological properties

Pharmacodynamics
The molecular mass of the complex is so large - about 50 kDa - that its diffusion through the mucous membrane of the gastrointestinal tract is 40 times slower than the diffusion of ferrous iron. The complex is stable and does not release iron ions under physiological conditions. The iron of the multinuclear active zones of the complex is bound into a structure similar to the structure of the natural iron compound - ferritin. Due to this similarity, the iron (III) of this complex is absorbed only by active absorption. Iron-binding proteins found on the surface intestinal epithelium and in gastrointestinal fluid, absorb iron (III) from the complex through competitive ligand exchange. Absorbed iron is mainly deposited in the liver, where it binds to ferritin. Later in bone marrow it is included in hemoglobin.
The polymaltose complex of iron (III) hydroxide, unlike iron (II) salts, does not have pro-oxidant properties. The sensitivity of lipoproteins (eg, very low-density lipoproteins and low-density lipoproteins) to oxidation is reduced.
Pharmacokinetics
Studies using the dual isotope method (55 Fe and 59 Fe) have shown that iron absorption, measured by red blood cell hemoglobin levels, is inversely related to dose taken(the higher the dose, the lower the absorption). There is a statistically negative correlation between the degree of iron deficiency and the amount of iron absorbed (the higher the iron deficiency, the better the absorption).
Maximum absorption of iron occurs in the duodenum and jejunum. Unabsorbed iron is excreted in the feces. Its excretion in exfoliated epithelial cells of the gastrointestinal tract and skin, as well as in sweat, bile and urine is approximately 1 mg of iron per day.
Women experience additional iron loss during menstruation, which must be taken into account.

Indications for use

Treatment of latent iron deficiency;
treatment iron deficiency anemia;
prevention of iron deficiency during pregnancy.

Contraindications for use

Hypersensitivity to the components of the drug,
iron overload in the body (for example, in cases of hemochromatosis, hemosiderosis);
impaired iron utilization (for example, anemia caused by lead intoxication, sideroachrestic anemia, thalassemia);
anemia not associated with iron deficiency (for example, hemolytic anemia, megaloblastic anemia due to vitamin B12 deficiency);
childhood up to 12 years (for this dosage form).

Carefully

No data.

Use during pregnancy and breastfeeding

Before starting to use the drug during pregnancy or breastfeeding, you should consult your doctor.
During controlled studies in pregnant women (2nd and 3rd trimesters of pregnancy), no negative impact on the organisms of mother and fetus. Not found harmful effects on the fetus when taking drugs in the first trimester of pregnancy.
Breast milk A nursing mother normally contains iron bound to lactoferrin. Data on the amount of iron entering mother's milk from a complex with polymaltose are absent. However, the emergence unwanted effects those on breastfeeding children are unlikely.

Directions for use and doses

Orally, the tablets can be chewed or swallowed whole. It is recommended to take the drug during or immediately after meals.
Daily dose can be divided into several steps.
Doses and duration of treatment depend on the degree of iron deficiency.
Latent iron deficiency
The duration of treatment is about 1-2 months.

Iron-deficiency anemia
The duration of treatment is about 3-5 months. After normalization of hemoglobin concentration, you should continue taking the drug for several more weeks to replenish iron reserves in the body.
Children over 12 years of age, adults and mothers breastfeeding
1-3 chewable tablets (100-300 mg) Ferrum Lek ® per day.
Pregnant women
Latent iron deficiency and prevention of iron deficiency
1 chewable tablet (100 mg) Ferrum Lek ® per day.
Iron-deficiency anemia
2-3 chewable tablets (200-300 mg) Ferrum Lek ® per day until the hemoglobin concentration normalizes.
After this, you should continue to take 1 chewable tablet per day, by at least, until the end of pregnancy to replenish iron reserves in the body.

Daily doses of the drug Ferrum Lek ® tablets for the prevention and treatment of iron deficiency in the body

Side effect

Ferrum Lek ® is generally well tolerated. Side effects are predominantly mild and transient in nature.
According to the World Health Organization (WHO), adverse reactions are classified according to their frequency of development as follows: very often (≥1/10), often (≥1/100,<1/10), нечасто (≥1/1000, <1/100), редко (≥1/10000, <1/1000) и очень редко (<1/10000); частота неизвестна – по имеющимся данным установить частоту возникновения не представлялось возможным.
Nervous system disorders
infrequently: headache.
Gastrointestinal disorders
Often: change in the color of feces (due to the excretion of unabsorbed iron, has no clinical significance);
often: diarrhea, nausea, dyspepsia;
very rarely: abdominal pain, constipation, vomiting, discoloration of tooth enamel.
Skin and subcutaneous tissue disorders
very rarely: urticaria, rash, itching of the skin.
If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction with other drugs

The composition of the drug Ferrum Lek ® includes complex-bound iron, which causes a low probability of ionic interactions with food components (oxalates, tannins, etc.), as well as with other drugs (for example, tetracyclines, antacids).
No interactions with other drugs or food products have been identified.
Concomitant use of polymaltosate hydroxide with parenteral iron preparations and other oral iron (III) preparations is not recommended due to the pronounced inhibition of the absorption of orally administered iron.

special instructions

In cases of anemia caused by an infectious or malignant disease, iron accumulates in the reticuloendothelial system, from which it is mobilized and utilized only after the underlying disease has been cured.
When using the drug Ferrum Lek ®, the stool may turn dark, which does not have any clinical significance. The drug Ferrum Lek ® does not affect the results of the occult blood test (selective for hemoglobin); therefore, it is not necessary to interrupt iron therapy.
Note for patients with diabetes: 1 chewable tablet of Ferrum Lek ® contains 0.04 bread units (BA).
Note for patients with phenylketonuria: Ferrum Lek ® contains aspartame (E951), a source of phenylalanine, in an amount equivalent to 1.5 mg per tablet.

Impact on the ability to drive vehicles and machinery

Ferrum Lek ® does not affect the ability to drive a car or operate machinery that requires increased concentration.

Special precautions when disposing of unused drugs

Not applicable.

Release form

Chewable tablets 100 mg.
Primary packaging
10 tablets are placed in an Al/Al strip or Al/Al blister.
Secondary packaging
3, 5 or 9 strips or blisters are placed in a cardboard box along with instructions for medical use.

Storage conditions

At a temperature not higher than 25°C.
Keep out of the reach of children.

Best before date

5 years.
Do not use the drug after the expiration date.

Vacation conditions

On prescription.

Manufacturer

Lek d.d., Verovshkova 57, Ljubljana, Slovenia.
Direct consumer complaints
ZAO Sandoz 125315, Moscow, Leningradsky Prospekt, 72, bldg. 3.

The drug Ferrum Lek belongs to the group of antianemic drugs and is prescribed to patients for the treatment and prevention of iron deficiency anemia.

Release form and composition of the drug

The drug Ferrum Lek is available in the form of chewable brown tablets with a pleasant chocolate smell. Tablets are available in foil strips of 10 pieces (1-3) in a cardboard box. The box with the drug contains instructions with detailed annotations.

Each tablet of the drug contains 100 mg of iron; the excipients are: aspartame, chocolate flavoring, macrogol, talc.

Indications for use

Ferrum Lek tablets are prescribed to adults and children over 13 years of age for the treatment and prevention of iron deficiency anemia during periods of increased body need for iron, namely:

period of intensive growth;
increased physical activity;
malnutrition, poor diet;
vegetarianism;
pregnancy and breastfeeding;
rehabilitation period after serious blood loss.

Contraindications

Before starting to take the drug, you should consult your doctor and be sure to take a blood test to determine your hemoglobin level. Please read the instructions carefully before starting treatment, as Ferrum Lek has a number of contraindications:

hemochromatosis – increased iron content in the body;
diseases of the small intestine that prevent the absorption of iron in the body;
anemia not associated with iron deficiency in the body (hemolytic anemia, anemia due to vitamin B12 deficiency, megaloblastic anemia);
individual intolerance to the components of the drug;
intoxication of the body with lead - in this case, the excretion of iron is impaired;
age of children under 12 years (for this dosage form of the drug).

Directions for use and dosage regimen

Ferrum Lek tablets are intended for oral administration. The tablet is chewed or dissolved in the mouth until completely dissolved. It is recommended to take the drug 1 hour after a meal; it is better not to chew the tablet on an empty stomach, as this may provoke an attack of nausea. The daily dose and duration of treatment is determined by the doctor, depending on the indications and individual characteristics of the patient’s body. For therapeutic purposes, according to the instructions, patients are prescribed 300 mg of iron per day, that is, 3 tablets. This dose can be taken at one time or divided into 2-3 doses. After stabilizing the level of hemoglobin in the body, take 1 tablet of Ferrum Leka for another month so that a depot (iron reserve) is formed in the body.

For the purpose of prevention during breastfeeding or other periods of life that require increased intake of iron into the body, 1 tablet of Ferrum Leka is prescribed once a day.

Use during pregnancy and lactation

The drug Ferrum Lek can be taken during pregnancy, starting from the first weeks. The dose of the drug is determined by the doctor and only after taking a blood test to determine hemoglobin and color index. A woman can take the drug until childbirth and continue taking tablets in a prophylactic dose during breastfeeding.

During breastfeeding, a woman is prescribed 1 to 3 tablets per day to prevent iron deficiency anemia in the mother and newborn. If the child experiences the slightest adverse reaction, you should stop taking the drug and consult a doctor.

Adverse reactions

The drug is usually well tolerated by patients, but if the dosage regimen is violated, the tablets are taken on an empty stomach, or in persons with increased individual sensitivity, side effects may develop:

nausea, vomiting;
stomach pain;
the appearance of a metallic taste in the mouth;
bloating;
constipation;
heartburn.

In some cases, it is possible to develop allergic reactions in the form of a rash on the skin and redness of certain areas of the body. As a rule, these effects are mild and quickly disappear on their own.

Overdose

Cases of overdose with Ferrum Lek have not been described with the correct dosage regimen. When taking large doses of the drug and developing excess hemoglobin in the body, the adverse reactions described above may increase.

If a large number of tablets are accidentally ingested, the patient must induce vomiting and be given one of the enterosorbent preparations, for example Activated Charcoal.

Interaction with other drugs

Iron preparations are not recommended to be prescribed to patients simultaneously with antacid substances, enveloping substances, or sorbents, since this drug interaction leads to impaired absorption of iron and a decrease in the therapeutic effect of Ferrum Leka.

special instructions

During drug therapy, the patient's stool may turn black, which is normal and occurs due to incomplete absorption of iron in the small intestine.

During the period of therapy, the patient is recommended to undergo periodic blood tests from a finger prick in order to be able to assess the effectiveness of the prescribed treatment. If, after 14 days from the start of treatment, the hemoglobin level has not increased or has become lower, it is necessary to undergo examination for internal bleeding or diseases of the small intestine.

In this dosage form, Ferrum Lek is not prescribed to children under 12 years of age, since there is no experience in using tablets. If therapy is necessary, patients aged 1 to 12 years are prescribed the drug in the form of syrup or drops, or an analogue is selected.

Ferrum Lek tablets do not cause dark staining of the enamel and do not affect the results of the fecal occult blood test.

The drug does not affect the functioning of the central nervous system and the speed of psychomotor reactions.

Analogs of chewable tablets Ferrum Lek

Analogues of the drug Ferrum Lek are:

Before replacing the prescribed drug with one of the recommended analogues, it is advisable for the patient to carefully read the attached leaflet, since the dosage of iron may be different.

Conditions of release and storage

The drug Ferrum Lek can be purchased in pharmacies without a doctor's prescription. Tablets should be stored in a dry, dark place out of reach of children. Avoid direct sunlight on the packaging. The optimal storage temperature for tablets should not exceed 25 degrees, the shelf life is 3 years from the date of manufacture indicated on the packaging.

Ferrum Lek price

The average cost of Ferrum Lek tablets in Moscow pharmacies is 310 rubles.

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FERRUM LEK chewable tablets instructions for use

Ferrum Lek in the form of chewable tablets and syrup is taken orally in one or more doses. The tablets are taken during or immediately after meals, chewed or swallowed whole. The syrup is given to children during or immediately after meals; you can mix it with fruit or vegetable juice in a feeding bottle. 1 dosage spoon (d.l.) contains 5 ml of the drug.

Severe iron deficiency

For children under 1 year of age, the initial dose is 2.5 ml (1/2 dl) syrup. Then it is gradually increased to 5 ml (1 dl) syrup/day.

Children aged 1 to 12 years - 5-10 ml (1-2 dl) syrup/day.

Children over 12 years of age, adults, nursing mothers - 1-3 tablets. or 10-30 ml (2-6 d.l.) syrup/day.

The drug is used for 3-5 months until hemoglobin levels normalize, and then for several more weeks to replenish iron reserves in the body.

Iron deficiency anemia during pregnancy

Prescribe 2-3 tablets. or 20-30 ml (4-6 d.l.) syrup/day until hemoglobin levels normalize. Then the dose is reduced to 1 tablet. or 10 ml (2 d.l.) syrup/day and continue therapy at least until the end of pregnancy to replenish iron reserves in the body.

Latent iron deficiency

Due to the low recommended dose, Ferrum Lek is not prescribed to children under 1 year of age.

Children aged 1 to 12 years are prescribed 2.5-5 ml (1/2-1 d.l.) of syrup per day.

Children over 12 years of age and adults (including women during breastfeeding) - 1 tablet. or 5-10 ml (1-2 dl) syrup/day. Treatment continues for 1-2 months.

During pregnancy, the drug is prescribed 1 tablet. or 5-10 ml (1-2 d.l.) syrup/day.

Daily doses of Ferrum Lek for the prevention and treatment of iron deficiency are presented in the table.

(-) the required dose is very low; tablets and syrup are not prescribed for this indication.

To correctly measure the dose of syrup, you should use a dosage spoon. The appearance of slight coloring does not affect the taste and effectiveness of the drug.

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FERRUM LEK

Doses and duration of treatment depend on the degree of iron deficiency.

The syrup can be mixed with fruit or vegetable juices or added to baby food. The measuring spoon included in the package is used for precise dosing of syrup.

For iron deficiency anemia, the duration of treatment is about 3-5 months. After normalization of hemoglobin levels, you should continue taking the drug for several more weeks to replenish iron reserves in the body.

Children under 1 year of age are prescribed 2.5-5 ml (1/2-1 scoop) of syrup/day.

Children aged 1 to 12 years - 5-10 ml (1-2 scoops) of syrup/day.

Children over 12 years old, adults and mothers breastfeeding - 1-3 tablets. chewing or 10-30 ml (2-6 scoops) syrup/day.

Pregnant women are prescribed 2-3 tablets. chewing or 20-30 ml (4-6 scoops) of syrup until hemoglobin levels normalize. After this, you should continue to take 1 tablet. chewable or 10 ml (2 scoops) syrup/day, at least until the end of pregnancy to replenish iron reserves in the body.

For latent iron deficiency, the duration of treatment is about 1-2 months.

Children aged 1 to 12 years - 2.5-5 ml (1/2-1 scoop) of syrup/day.

Children over 12 years old, adults and mothers breastfeeding - 1 tablet. chewing or 5-10 ml (1-2 scoops) syrup/day.

Pregnant women are prescribed 1 tablet. chewable or 5-10 ml (1-2 scoops) syrup/day.

Daily doses of Ferrum Lek® for the prevention and treatment of iron deficiency in the body.

* - due to the fact that this group of patients requires low doses of iron, it is not recommended in these cases to prescribe the drug in the form of tablets or syrup.

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Ferrum Lek syrup - official instructions for use

catad_pgroup Antianemic drugs (iron preparations) Analogues, articles Comments

INSTRUCTIONS for medical use of the drug

Read these instructions carefully before you start using this medicine. Save the instructions, you may need them again. If you have any questions, consult your doctor. This medicine is for you personally and should not be given to others because it may harm them even if they have the same symptoms as you.

Registration number:

Trade name of the drug:

Ferrum Lek®.

International nonproprietary name or generic name:

iron (III) hydroxide polymaltosate.

5 ml of syrup (1 measuring spoon) contains: Active substance: iron 50.0 mg (which corresponds to 200.00 mg of iron (III) hydroxide polymaltose). Excipients: sucrose – 1,000 g; sorbitol (solution) – 2,000 g; methyl parahydroxybenzoate – 2.915 mg; propyl parahydroxybenzoate – 0.830 mg; ethanol – 16.250 mg; cream flavoring – 15,000 mg; sodium hydroxide – up to pH 5.0-7.0; water – up to 5 ml.

Description

Transparent brown solution.

Pharmacotherapeutic group

Antianemic agent. Iron supplement.

ATX code: В03АВ05.

Pharmacological properties

Pharmacodynamics The molecular mass of the complex is so large - about 50 kDa - that its diffusion through the mucous membrane of the gastrointestinal tract is 40 times slower than the diffusion of divalent iron. The complex is stable and does not release iron ions under physiological conditions. The iron of the multinuclear active zones of the complex is bound into a structure similar to the structure of the natural iron compound - ferritin. Due to this similarity, the iron (III) of this complex is absorbed only by active absorption. Iron-binding proteins, located on the surface of the intestinal epithelium and in gastrointestinal fluid, absorb iron (III) from the complex through competitive ligand exchange. Absorbed iron is mainly deposited in the liver, where it binds to ferritin. Later in the bone marrow it is incorporated into hemoglobin. The polymaltose complex of iron (III) hydroxide, unlike iron (II) salts, does not have pro-oxidant properties. The sensitivity of lipoproteins (eg, very low-density lipoproteins and low-density lipoproteins) to oxidation is reduced.

Pharmacokinetics

Studies using the dual isotope method (55Fe and 59Fe) have shown that iron absorption, as measured by red blood cell hemoglobin levels, is inversely proportional to the dose administered (the higher the dose, the lower the absorption). There is a statistically negative correlation between the degree of iron deficiency and the amount of iron absorbed (the higher the iron deficiency, the better the absorption). Maximum absorption of iron occurs in the duodenum and jejunum. Unabsorbed iron is excreted in the feces. Its excretion in exfoliated epithelial cells of the gastrointestinal tract and skin, as well as in sweat, bile and urine is approximately 1 mg of iron per day. Women experience additional iron loss during menstruation, which must be taken into account.

Indications for use

Treatment of latent iron deficiency; treatment of iron deficiency anemia;

Prevention of iron deficiency during pregnancy.

Hypersensitivity to the components of the drug, iron overload in the body (for example, in cases of hemochromatosis, hemosiderosis); impaired iron utilization (for example, anemia caused by lead intoxication, sideroachrestic anemia, thalassemia); anemia not associated with iron deficiency (for example, hemolytic anemia, megaloblastic anemia due to vitamin B12 deficiency);

Rare hereditary forms of fructose intolerance, glucose-galactose malabsorption and sucrase-isomaltase deficiency (since the drug contains sucrose and sorbitol).

Carefully

Patients with diabetes.

Use during pregnancy and lactation

In controlled studies in pregnant women (2nd and 3rd trimesters of pregnancy), no negative effects on the mother and fetus were noted. No harmful effects on the fetus were detected when taking the drugs in the first trimester of pregnancy. When a nursing mother uses the drug, only a small part of the iron from its complex with polymaltose enters breast milk; therefore, adverse effects are unlikely to occur in breastfed infants.

Inside. It is recommended to take the drug during or immediately after meals. Ferrum Lek® syrup can be mixed with fruit or vegetable juices or added to baby food. The daily dose can be divided into several doses. The measuring spoon included in the package is used for precise dosing of Ferrum Lek® syrup. Doses and duration of treatment depend on the degree of iron deficiency.

Latent iron deficiency

The duration of treatment is about 1-2 months.

Children under 1 year of age:

Due to the low dosage, the use of syrup for this indication is impossible.

Children from 1 to 12 years old

2.5-5 ml (1/2-1 scoop) Ferrum Lek® syrup per day. Children over 12 years of age, adults and mothers breastfeeding 5-10 ml (1-2 scoops) of Ferrum Lek® syrup per day. Iron deficiency anemia Duration of treatment is about 3-5 months. After normalization of hemoglobin concentration, you should continue taking the drug for several more weeks to replenish iron reserves in the body.

Children under 1 year of age

The initial dose of Ferrum Lek® syrup is 2.5 ml (1/2 measuring spoon) per day. The dose is gradually increased to 5 ml (1 scoop) of Ferrum Lek® syrup per day. Children from 1 to 12 years old: 5-10 ml (1-2 scoops) of Ferrum Lek® syrup per day. Children over 12 years of age, adults and mothers breastfeeding 10-30 ml (2-6 scoops) of Ferrum Lek® syrup per day. Pregnant women Latent iron deficiency 10 ml (2 scoops) of Ferrum Lek® syrup per day. Prevention of iron deficiency 5-10 ml (1-2 measuring spoons) of Ferrum Lek® syrup per day. Iron deficiency anemia 20-30 ml (4-6 measuring spoons) of Ferrum Lek® syrup per day until the hemoglobin concentration is normalized. After this, you should continue to take 10 ml (2 scoops) of Ferrum Lek® syrup per day, at least until the end of pregnancy to replenish iron reserves in the body.

Daily doses of Ferrum Lek® syrup for the prevention and treatment of iron deficiency in the body

Side effect

Ferrum Lek® is generally well tolerated. Side effects are predominantly mild and transient. According to the World Health Organization (WHO), adverse reactions are classified according to their frequency of development as follows: very often (≥1/10), often (≥1/100,

Active substance

Iron hydroxide polymaltose (iron polymaltose)

Release form, composition and packaging

Chewable tablets dark brown, interspersed with light brown, round, flat, chamfered.

Excipients: macrogol 6000, aspartame, chocolate flavor, talc, dextrates.

10 pieces. - strips (3) - cardboard packs.

Syrup transparent, brown.

Excipients: sucrose, sorbitol (solution), methyl parahydroxybenzoate, propyl parahydroxybenzoate, ethanol, cream flavor, sodium hydroxide, water.

100 ml - dark glass bottles (1) complete with a measuring spoon - cardboard packs.

pharmachologic effect

Antianemic drug. The preparation contains iron in the form of a complex compound of iron (III) hydroxide polymaltosate.

The molecular mass of the complex is so large (about 50 kDa) that its diffusion through the gastrointestinal mucosa is 40 times slower than the diffusion of ferrous iron. The complex is stable and does not release iron ions under physiological conditions. The iron of the multinuclear active zones of the complex is bound into a structure similar to the structure of the natural iron compound - ferritin. Due to this similarity, the iron in this complex is absorbed only through active absorption. Iron-binding proteins located on the surface of the intestinal epithelium absorb iron (III) from the complex through competitive ligand exchange. Absorbed iron is mainly deposited in the liver, where it binds to ferritin. Later in the bone marrow it is incorporated into hemoglobin. Iron (III) complex hydroxide polymaltosate does not have the pro-oxidant properties inherent in iron (II) salts.

Pharmacokinetics

Studies using the dual isotope method (55 Fe and 59 Fe) have shown that iron absorption, measured by red blood cell hemoglobin levels, is inversely proportional to the dose administered (the higher the dose, the lower the absorption). There is a statistically negative correlation between the degree of iron deficiency and the amount of iron absorbed (the greater the iron deficiency, the better the absorption). Iron is absorbed to the greatest extent in the duodenum and jejunum. The remaining (unabsorbed) iron is excreted in the feces. Its excretion with exfoliating epithelial cells of the gastrointestinal tract and skin, as well as with sweat, bile and urine is approximately 1 mg of iron/day. Women experience additional iron loss during menstruation, which must be taken into account.

Indications

- treatment of latent iron deficiency;

- treatment of iron deficiency;

- prevention of iron deficiency during pregnancy.

Contraindications

- excess iron content in the body (for example, hemochromatosis);

- disorders of iron utilization (for example, anemia caused by lead intoxication, sideroachrestic anemia);

- anemia not associated with iron deficiency (for example, hemolytic anemia, megaloblastic anemia caused by iron deficiency);

- hypersensitivity to the components of the drug.

Dosage

Doses and duration of treatment depend on the degree of iron deficiency.

The syrup can be mixed with fruit or vegetable juices or added to baby food. The measuring spoon included in the package is used for precise dosing of syrup.

At iron deficiency anemia The duration of treatment is about 3-5 months. After normalization of hemoglobin levels, you should continue taking the drug for several more weeks to replenish iron reserves in the body.

Children under 1 year of age Prescribe 2.5-5 ml (1/2-1 measuring spoon) of syrup/day.

5-10 ml (1-2 scoops) syrup/day.

1-3 tab. chewing or 10-30 ml (2-6 scoops) syrup/day.

Pregnant women Prescribe 2-3 tablets. chewing or 20-30 ml (4-6 scoops) of syrup until hemoglobin levels normalize. After this, you should continue to take 1 tablet. chewing or 10 ml (2 scoops) syrup/day, at least until the end to replenish iron reserves in the body.

At latent iron deficiency The duration of treatment is about 1-2 months.

Children aged 1 to 12 years- 2.5-5 ml (1/2-1 measuring spoon) syrup/day.

Children over 12 years of age, adults and mothers breastfeeding,- 1 tab. chewing or 5-10 ml (1-2 scoops) syrup/day.

Pregnant women prescribed 1 tablet. chewable or 5-10 ml (1-2 scoops) syrup/day.

Daily doses of Ferrum Lek for the prevention and treatment of iron deficiency in the body.

* - due to the fact that this group of patients requires low doses of iron, it is not recommended in these cases to prescribe the drug in the form of tablets or syrup.

Side effects

From the digestive system: very rarely - a feeling of heaviness, a feeling of fullness and pressure in the epigastric region, nausea, diarrhea. When taking the drug, stool becomes dark in color, which is due to the excretion of unabsorbed iron and has no clinical significance.

The side effects reported were mostly mild and transient.

Overdose

In cases of overdose of Ferrum Lek for oral administration, no signs of intoxication or signs of excess iron intake into the body have been described to date, since iron from the active substance is not present in the gastrointestinal tract in free form and is not absorbed by passive diffusion.

Drug interactions

No interactions with other drugs or foods were noted.

special instructions

Chewable tablets and syrup do not stain tooth enamel.

When prescribing Ferrum Lek to patients with diabetes mellitus, it should be taken into account that 1 tablet. chewable and 1 ml of syrup contains 0.04 XE.

Taking the drug does not affect the results of stool tests for occult blood (selectively for hemoglobin).

Use in pediatrics

Children under 12 years of age Due to the need to prescribe the drug in low doses, it is preferable to use it in the form of syrup.

Impact on the ability to drive vehicles and operate machinery

Does not affect the ability to concentrate.

Storage conditions and periods

The drug should be stored out of the reach of children at a temperature not exceeding 25°C. The shelf life of chewable tablets is 5 years, syrup - 3 years. Do not use after expiration date.