Ersefuril: instructions, use, reviews. Instructions for the use of ersefuril for acute bacterial diarrhea

Most people are familiar with the condition of diarrhea. This disease is provoked by various reasons: it can be trivial reasons, such as low-quality food, alcohol and the like, but sometimes more dangerous - intestinal infections. Many products have been developed to help treat this painful condition. The drug Ersefuril is one of the best antiseptics, although patients often mistakenly think that it is an antibiotic. It has a second name, international - “Nifuroxazide” (the same name as its active ingredient included in the composition). When using Ersefuril, the instructions for use must be studied and all recommendations specified in it must be followed.

Description of the drug Ersefuril

Externally, these are yellow capsules with powder of the same color. This medicine has an antidiarrheal effect. It is achieved by the fact that the drug blocks the redox processes of hostile microorganisms and prevents their further reproduction. If you know how to take Ersefuril, then it does not disturb the natural intestinal microflora and does not damage beneficial biotics. Its composition is quite gentle, so there is no effect on other organs. Memory and attention do not deteriorate, which makes it possible to use it in almost any situation.

This medicine remains 99% in the intestines, which allows it to demonstrate all its antimicrobial capabilities.

One tablet has the following composition:

Powder:

• 200 mg main active substance- nifuroxazide;
• 88 mg starch (corn);
• 72 mg sucrose;
• 8 mg magnesium stearate.

Capsule:

• 2% titanium dioxide;
• 0.6% yellow dye (iron oxide);
• The rest of the shell is gelatin.

Release form

Ersefuril 200 mg sold in the following form: in a pack there are two blisters of 14 capsules.

Important! Ersefuril suspension does not exist. In this dosage form its analogue is produced - “Enterofuril” (which is produced in the form of a suspension) and has identical pharmacological properties and composition.

The infection may present with the following symptoms:

• Increased body temperature;
• Rumbling and pain in the abdomen;
• Flatulence (passing gas);
• Frequent loose stools (sometimes the number of visits to the toilet reaches 15 times a day);
• Fever;
• Vomit;
• Nausea;
• General intoxication.

Indications

Ersefuril has the following readings for use:

• Acute infectious diarrhea;
• Chronic colitis and enterocolitis of infectious etiology;
• Included complex therapy intestinal dysbiosis syndrome;
• Prevention of infectious complications from gastrointestinal tract during surgery.

Contraindications to the use of Ersefuril

Compound this drug excludes bad influence on the body, however, Ersefuril has a number of contraindications when it should be abandoned in favor of analogues:

• Individual intolerance to any components of the medication;
• This dosage form is prohibited for use in children under 6 years of age.

Important! During treatment with Ersefuril, alcohol consumption is strictly prohibited due to the risk of developing a disulfiram-like reaction (the person experiences extremely negative sensations).

Ersefuril contains sucrose, which should be taken into account when using the drug in patients with diabetes.

Use during pregnancy or breastfeeding

Ersefuril during pregnancy is used only as prescribed by a doctor because not enough research has been done in this area. If it is used, it is only for a short period. It is also prescribed when the use of safer analogues is not possible, and the disease is progressive in nature and there is any risk to the mother or fetus.

Lactation period

You need to know that Ersefuril is not absorbed from the gastrointestinal tract and, accordingly, cannot penetrate into breast milk, therefore, for women during breastfeeding there are no restrictions on use of this medication No. The main thing is to follow the dosage and take into account all the recommendations of your doctor.

Side effects

Each body is unique and may respond differently to medications.

Possible adverse reactions:

• Temporary abdominal pain;
• Increased diarrhea;
• Nausea;
• Allergies in the form of itching, skin rashes;
• Quincke's edema rarely occurs;
• Dyspnea.

Instructions for use

It is important to know how to take Ersefuril and how many days treatment lasts in adults and children.

• Adults need to take 4 capsules, divided into 2-4 doses per day. It is important not to exceed a single dose of 400 mg (2 tablets) and a daily dose of 800 mg.
• Children over 14 years of age are prescribed in the following doses: 1 capsule 3-4 times a day (with a 6-hour interval);
• Children from 6 to 14 years old in even smaller quantities - 1 tablet three times a day (8-hour intervals).

The duration of therapy for patients of any age is no longer than 7 days. The therapeutic effect is achieved after the first hours of taking the medication.

Instructions for use are in the box; in the annotation you can study in more detail the composition, dosage, depending on age, features of use and other details.

With diarrhea, fluid levels in the body drop significantly and require speedy recovery. Concomitant rehydration therapy (oral or intravenous) is necessary depending on the intensity of diarrhea, additional symptoms and the patient's well-being.

After 2-3 days of treatment, the main signs of the disease will go away and the general condition will improve. If relief is not observed, then it is necessary to reconsider the treatment. In addition, Ersefuril can be combined with other drugs to achieve stronger therapeutic effect. However, it should not be used simultaneously with sorbents and medications containing alcohol.

• It is necessary to take the medicine big amount clean water;
• You can take the drug during meals, before eating, or after, it doesn’t matter;
• Treatment should begin only with a doctor's prescription;
• During the course of therapy, a diet is recommended, at least minimal (excluding foods with a laxative effect). However for maximum results It is worth observing a stricter diet.

Analogs

Ersefuril has the following analogues:

• Enterofuril (this is not a syrup, but a suspension, despite possible flavoring additives);
• Nifuroxazil-Richter (you can purchase it for more affordable price, and the composition and properties are identical to Ersefuril).
• Furazolidone (much cheaper, but has more restrictions).

Self-medicating can only make the situation worse. Visit a specialist if you have prolonged loose stools, since it is important to identify the root cause of the disease.

3D images

Compound

Description of the dosage form

Hard gelatin capsules No. 1, consisting of a body and a cap yellow color.

Capsule contents- yellow powder.

pharmachologic effect

pharmachologic effect- antimicrobial.

Pharmacodynamics

Nifuroxazide - antimicrobial agent, a derivative of nitrofuran. Blocks the activity of dehydrogenases and inhibits the respiratory chain, the tricarboxylic acid cycle and a number of other biochemical processes in the microbial cell. Destroys the microbial cell membrane, reduces the production of toxins by microorganisms. Highly active against Campylobacter jejuni, Escherichia coli, Salmonella spp., Shigella spp., Clostridium perfringens, Vibrio cholerae, pathogenic Vibrions And Vibrio parahaemolytique, Staphylococcus spp.

Poorly sensitive to nifuroxazide: Citrobacter spp., Enterobacter cloacae And Proteus indologenes.

Resistant to nifuroxazide: Klebsiella spp., Proteus mirabilis, Providencia spp., Pseudomonas spp.

Doesn't upset the balance intestinal microflora. In acute bacterial diarrhea, it restores intestinal eubiosis. When infected with enterotropic viruses, it prevents the development of bacterial superinfection.

Pharmacokinetics

After oral administration Nifuroxazide is practically not absorbed from the digestive tract and exerts its antibacterial effect exclusively in the intestinal lumen. Nifuroxazide is excreted by the intestines: 20% is unchanged, and the remaining amount of nifuroxazide is chemically modified.

Indications of the drug Ersefuril ®

Acute bacterial diarrhea without worsening general condition, increased body temperature, intoxication.

Contraindications

increased sensitivity to nifuroxazide, nitrofuran derivatives or other components of the drug;

fructose intolerance, glucose-galactose malabsorption syndrome or sucrase and isomaltase deficiency (due to the presence of sucrose in the drug);

pregnancy;

children under 3 years of age.

Use during pregnancy and breastfeeding

In animal studies, nifuroxazide did not show a teratogenic effect. However, as a precautionary measure, it is not recommended to take nifuroxazide during pregnancy (insufficient clinical experience use during pregnancy).

During the lactation period it is possible to continue breastfeeding when short course drug treatment. You should consult your doctor.

Side effects

Allergic reactions ( skin rashes, urticaria, Quincke's edema, anaphylactic shock).

If any of the side effects listed in the description worsen, or the patient notices any other side effects, not listed in the description, you should inform your doctor.

Interaction

If the patient is taking other medications(including over-the-counter medications), before using the drug Ersefuril ® you should consult your doctor.

Directions for use and doses

Inside.

Children from 3 to 6 years old- 200 mg (1 capsule) 3 times a day (interval between doses - 8 hours).

Children from 6 to 18 years old- 200 mg (1 capsule) 3-4 times a day (interval between doses - 6-8 hours).

For adults- 200 mg (1 capsule) 4 times a day (interval between doses - 6 hours).

Duration of treatment: 5-7 days, but not more than 7 days.

If there is no improvement within the first 3 days of taking it, you should consult a doctor.

The drug should be used only according to the method of application and in the doses indicated in the description. If necessary, consult a doctor before using the drug.

Overdose

Symptoms: unknown.

Treatment: symptomatic.

special instructions

When treating diarrhea, rehydration therapy must be carried out simultaneously with nifuroxazide therapy.

In case of bacterial diarrhea with signs of systemic damage (deterioration of general condition, increased body temperature, symptoms of intoxication or infection), you should consult a doctor to decide on the use of systemic antibacterial drugs. If symptoms of hypersensitivity occur (shortness of breath, skin rash, itchy skin) you should stop taking the drug. Drinking alcohol during therapy with nifuroxazide is prohibited.

Ersefuril instructions

The essence of treatment with this drug is to block the enzyme dehydrogenase. That is, substances responsible for carbohydrate and fat metabolism and oxidation in the microbial cell are inhibited. Nuforoxazide disrupts respiration, membranes, and metabolism in cells that cause intestinal infections.

Under the influence of the drug, the immune system is activated, namely, the titer of complement and phagocytosis increases. As a result, the engulfment of unwanted cells by phagocytes increases.

The effect of Ersefuril depends on the dosage. At lower dosages the effect is bacteriostatic, and at higher doses high doses– bactericidal. No overdose was observed.

The drug is successfully used against gram-positive and gram-negative microorganisms.

Addiction and the emergence of drug-resistant strains of bacteria do not occur. Also not developing.

Possible appearances allergic reactions, as side effects.

Contraindications for use: hypersensitivity to the drug and its components. Persons with fructose intolerance, acute insufficiency sucrase-isomaltase is not recommended medicine, due to the presence of glucose in the composition.

During pregnancy, capsules are prescribed with caution. Use is permitted during breastfeeding.

Ersefuril indications

Ersefuril analogues

Nifuroxazide, Enterofuril, Ecofuril are analogues of Ersefuril.

Ersefuril price

The price range is between 150 – 288 hryvnia.

Ersefuril reviews

Claudia

I've tried a lot various means from diarrhea for a lifetime. One of the most effective and safe, in my opinion, is Ersefuril. There are other good ones too. But today I keep this particular drug in my medicine cabinet. When I travel, I also don’t forget to take it with me, it can always come in handy. And we recently bought a suspension for the child, positive point- absence bad taste. There are no problems with the supply of medicine and dysbiosis does not need to be treated later.

The drug ersefuril, produced by the world-famous transnational pharmaceutical company"Sanofi Aventis, belongs to the group antibacterial agents and is used to treat acute diarrhea. Diarrhea is defined as an increase in bowel movements up to 3 or more times a day due to a thinning of the stool consistency. If similar condition lasts more than 2 weeks, then it is considered to be a chronic form of diarrhea, if less, it is acute. Diarrhea can be non-infectious and infectious. In developed countries, infectious diarrhea is most often caused by viruses transmitted by the fecal-oral route through food, water, or contact-household method. Separate form This disease is represented by traveler's diarrhea, which can sometimes develop when a person changes his geographic location. Treatment of diarrhea is carried out in several areas: rehydration therapy, taking zinc preparations, vitamins, macro- and microelements, using special diets, symptomatic treatment And antibacterial therapy. The need to include antibacterial agents in the treatment regimen depends on clinical picture diseases. If the diarrhea is non-inflammatory, the degree of dehydration is low and the disease is not at risk of developing chronic form, then you can do without antibacterial agents. If diarrhea occurs in an inflammatory manner against the background of severe dehydration and tends to become chronic, then antibacterial therapy is mandatory. Moreover, in the vast majority of cases, drug selection is carried out empirically, because the cost of stool culture is too high to use this diagnostic method on an ongoing basis. Ersefuril is the drug of choice for acute infectious diarrhea, which occurs without significant deterioration in the patient’s general condition, fever, or symptoms of poisoning (exo- or endogenous). Along with other nitrofurans, ersefuril prevents the occurrence of certain oxido-reductase reactions in bacterial cells.

When used in recommended doses, it has a bacteriostatic effect, i.e. does not destroy bacteria, but prevents their growth and reproduction. In high doses, the drug exhibits bactericidal activity, i.e. cause the death of microorganisms. Ersefuril is effective against infectious diarrhea caused by Escherichia coli, Campylobacter jejuni, Salmonella spp, Shigella spp, Vibrio cholerae, Vibrio parahaemolytique, Staphylococcus spp., Clostridium perfringens. Enterobacter cloacae, Citrobacter spp., Proteus indologenes are slightly sensitive to ersefuril. Completely resistant to the drug Proteus mirabilis, Providencia spp., Klebsiella spp., Pseudomonas spp. Ersefuril has virtually no effect on the normal saprophytic intestinal microflora (does not cause dysbiosis). Resistance to the drug does not develop in microorganisms sensitive to it.

Ersefuril is available in capsule form. The drug is used in adults and children over 6 years of age. Adults take 4 capsules per day (total 800 mg) in 2-4 doses, children - 3-4 capsules per day in the same 2-4 doses. The duration of the medication course is no more than 1 week. Active substance ersefuril - nifuroxazide - is practically not absorbed from the gastrointestinal tract: 99% of the taken amount remains in the intestines and fully fulfills its antibacterial purpose there. Elimination of ersefuril from the body is carried out by the intestines. If diarrhea is prolonged, accompanied by severe vomiting or complete loss of appetite, parenteral administration of water and electrolytes for rehydration should be considered. In the absence of any improvement due to more than two days of taking ersefuril, adjustments should be made to the treatment and, possibly, prescribing antimicrobials with good systemic diffusion.

Pharmacology

Like other nitrofurans, nifuroxazide blocks some redox enzyme reactions in microbial cells. When used in therapeutic doses It has a bacteriostatic effect, and in high doses it has a bactericidal effect. Highly active against Campylobacter jejuni, Escherichia coli, Salmonella spp., Shigella spp.; Clostridium perfringens, Vibrio cholerae, pathogenic Vibrions and Vibrio parahaemolytique, Staphylococcus spp.

Weakly sensitive to nifuroxazide: Citrobacter spp., Enterobacter cloacae and Proteus indologenes.

Resistant to nifuroxazide: Klebsiella spp., Proteus mirabilis, Providencia spp., Pseudomonas spp.

Does not affect saprophytic flora (does not cause dysbacteriosis). Resistance of microorganisms to the drug does not develop.

Pharmacokinetics

Nifuroxazide is practically not absorbed from the gastrointestinal tract, 99% dose taken remains in the intestines and exerts its influence there antimicrobial effect. Nifuroxazide is excreted through the intestines: 20% unchanged, and the remaining amount of nifuroxazide is chemically modified.

Release form

Hard gelatin capsules, size No. 1; yellow body, yellow cap; The contents of the capsules are yellow powder.

	1 caps.
nifuroxazide	200 mg

Excipients: corn starch - 88 mg, sucrose - 72 mg, magnesium stearate - 1.8 mg.

Composition of the capsule body: gelatin - up to 100%, titanium dioxide (E171) - 2%, yellow iron oxide dye (E172) - 0.6286%.
Composition of the capsule cap: gelatin - up to 100%, titanium dioxide (E171) - 2%, yellow iron oxide dye (E172) - 0.6286%.

14 pcs. - blisters (1) - cardboard packs.
14 pcs. - blisters (2) - cardboard packs.

Dosage

The drug is intended for oral administration only for adults or children over 6 years of age.

Adults: 4 capsules (800 mg) per day, divided into 2-4 doses.

Children over 6 years of age: 3-4 capsules (600-800 mg) per day, divided into 2-4 doses.

Duration of treatment: no more than 7 days.

Overdose

There is no data on overdose of the drug Ersefuril ®.

Interaction

Data on drug interactions Ersefuril ® is not available.

Side effects

Allergic reactions: possible - skin rashes, urticaria, Quincke's edema, anaphylactic shock.

Indications

• acute bacterial diarrhea, occurring without deterioration in general condition, increase in body temperature, intoxication (in addition to adequate severity of diarrhea, rehydration by taking fluids and electrolytes orally or, if necessary, their intravenous administration).

Contraindications

• hypersensitivity to nitrofuran derivatives or any excipients drug;
• children under 6 years of age;
• pregnancy;
• fructose intolerance, glucose-galactose malabsorption syndrome or sucrase and isomaltase deficiency (due to the presence of sucrose in the drug).

Features of application

Use during pregnancy and breastfeeding

In animal studies, nifuroxazide did not show a teratogenic effect. However, as a precautionary measure, taking nifuroxazide during pregnancy is not recommended (insufficient clinical experience with use during pregnancy).

During the lactation period, it is possible to continue breastfeeding in case of a short course of treatment with the drug.

Use in children

Contraindicated for children under 6 years of age.

special instructions

In case of bacterial diarrhea with signs of systemic damage (deterioration of general condition, increased body temperature, symptoms of intoxication or infection), it should be used antibacterial drugs with good systemic diffusion.

In the case of pronounced prolonged diarrhea, severe vomiting or refusal to eat, consider intravenous administration fluids and electrolytes for rehydration.

If diarrhea persists for more than 2 days during treatment, treatment should be reconsidered and the need for oral or intravenous fluids and electrolytes should be considered. The volume of fluid administered and the method of its administration (orally, intravenously) should correspond to the severity of diarrhea, age and clinical condition patient.

Impact on the ability to drive vehicles and operate machinery

The drug does not affect the ability to control vehicles or occupations with others potentially dangerous species activities.

5 ml (1 scoop) 4% suspension (with banana flavor) for oral administration - 220 mg; in glass bottles of 90 ml.

Pharmacodynamics of the drug Ersefuril

Antimicrobial agent wide range actions, nitrofuran derivative. Blocks the activity of dehydrogenases and inhibits the respiratory chain, the tricarboxylic acid cycle and a number of other biochemical processes in the microbial cell. Destroys the microbial cell membrane, reduces the production of toxins by microorganisms. Activates the immune system: increases phagocytosis and complement titer. Effective against gram-positive (Staphylococcus spp., Streptococcus spp., Haemophilus influenzae) and gram-negative (Salmonella spp., Klebsiella spp., Enterobacter spp., Escherichia coli, Shigella spp., Proteus spp.) microorganisms. Does not disturb the balance of intestinal microflora. In acute bacterial diarrhea, it restores intestinal eubiosis. When infected with enterotropic viruses, it prevents the development of bacterial superinfection.

Pharmacokinetics of the drug Ersefuril

It is practically not absorbed and acts in the intestinal lumen.

Contraindications to the use of the drug Ersefuril

Hypersensitivity (including to other nitrofuran derivatives); newborns (up to 1 month).

Side effects of the drug Ersefuril

Allergic reactions are extremely rare.

Method of administration and dosage of the drug Ersefuril

Inside, adults - 1 capsule. (200 mg) 4 times a day; children from 1 to 30 months - 1-3 measuring spoons (220-660 mg) of the suspension in 2-3 doses, over 30 months - 1 measuring spoon 3 times a day (shake the suspension before use). The course of treatment is no more than 7 days.

Precautions when taking Ersefuril

Rehydration should be carried out if necessary. The volume of fluid administered and the method of its administration (per os, IV) should correspond to the severity of diarrhea, age and clinical condition of the patient. In case of infectious diarrhea, systematic antibacterial therapy is necessary. The drug should not be prescribed for congenital deficiency of the enzyme that breaks down sucrose (when using the suspension in newborns).

Special instructions when taking Ersefuril

Before prescribing the suspension infants it is necessary to exclude congenital deficiency of enzymes that break down sucrose. Can be prescribed to pregnant and lactating women. Ethanol intake may cause hypersensitivity symptoms.

Storage conditions for the drug Ersefuril

In a cool place, protected from light.

Shelf life of the drug Ersefuril

The drug Ersefuril belongs to the ATX classification:

A Digestive tract and metabolism

A07 Antidiarrheal, intestinal anti-inflammatory and antimicrobial drugs

A07A Intestinal antimicrobials

A07AX Other intestinal antimicrobials