home Audience 6 Real experience of using Phenazepam: reviews, clinical studies, instructions. Phenazepam: instructions for use, analogues and reviews, prices in Russian pharmacies

Real experience of using Phenazepam: reviews, clinical studies, instructions. Phenazepam: instructions for use, analogues and reviews, prices in Russian pharmacies

The drug can relieve unreasonable fear and tension emotional nature. It is also used during epilepsy, with tics and hyperkinesis, during the development of rigidity of muscle structures, and autonomic lability.

The medicine is used internally. It greatly affects the activity of various brain structures. Some patients, due to the action of the drug, experience headaches, migraines, a depressed state, or, conversely, causeless agitation.

Can symptoms occur in patients who take an excessive dose?

In case of an overdose of Phenazepam, the instructions for use describe the following symptoms:

If the dose was relatively moderate, then the patient’s side effects increase or the therapeutic effect of Phenazepam increases.
With a large dose of overdose, cardiac activity is depressed, breathing problems arise, and the person is in a depressed state.

When should this medication not be used?

Contraindications to the use of this medicine are as follows:

Comatose or shock state.
Myasthenia.
An acute attack of angle-closure glaucoma or a predisposition to this disease.
Severe diseases of the respiratory system and lungs, which can cause respiratory failure.
Pregnancy and lactation period. It is especially prohibited to use the drug during the first trimester of pregnancy.
If the patient is not older than 18 years.
High human sensitivity to benzodiazepines.
If the patient complains of a decrease in the ability to remember any information.

Some people treated with this medicine have a tendency to make erratic movements. In many patients, as side effects myasthenia, dysarthria, and asthenia were noted.

The drug should not be taken while driving a vehicle or performing work that requires concentration and concentration. fast response. In children, the medicine causes depression of the central nervous system. Use of this medication with caution is recommended under the following circumstances:

The patient has renal or liver failure.
Ataxia of cerebral or spinal type.
Predisposition to abuse of psychotropic drugs.
Hyperkinesis and various organic diseases of brain structures.
During hypoproteinemia.
Depression.
If the patient is an elderly person.

A side effect while taking the medication may be a deterioration in the normal functioning of the liver. The main symptom in this case is yellowing of the sclera and skin of the patient. Kidney function may be impaired. Some patients complained of decreased libido. This drug may cause allergic reactions. Long-term treatment with Phenazepam leads to addiction.

What negative effects can this drug cause in patients?

Side effects of Phenazepam are as follows:

Constant craving for sleep.
Impaired coordination of movements.
The person becomes lethargic.
Brain function noticeably slows down.
Falls physical activity sick.

Some patients stated that they were visited by various visions. But most of the people whom doctors treated with Phenazepam experienced sleep disturbances. This medicine may have Negative influence for blood production. In this case, there is a shortage of red blood cells, which leads to an increase in the number of platelets and white blood cells. The patient's body reacts to this with fever. A person experiences sharp increase body temperature, he becomes lethargic. Treatment of diseases with Phenazepam often has a negative impact on work gastrointestinal tract patient. In this case, he begins to salivate profusely, vomiting and heartburn develop.

In many patients, this leads to an aversion to the food offered, causing constipation or diarrhea.

In patients, the pressure in the blood vessels sharply decreases, body weight drops, and the rhythm of the heart muscle may be disrupted. This drug has a negative effect on the development of the central nervous system of the fetus if the expectant mother takes the drug.

The nature of the side effect and its frequency largely depend on the dose taken, the duration of treatment and the individual sensitivity of the person. If undesirable effects occur, you should stop taking this drug. Before you start using Phenazepam, you should consult your doctor.

Phenazepam instructions for use, contraindications, side effects, reviews

Anxiolytic (tranquilizer), benzodiazepine derivative.

Active substance of the drug: non appropriated

ATX encoding: N05BX

KFG: Tranquilizer (anxiolytic)

Registration number: P No. 003747/01

Registration date: 02.11.04

Owner reg. holder: DALKHIMFARM OJSC

Phenazepam release form, drug packaging and composition.

The solution for intravenous and intramuscular administration is colorless or slightly colored.

Excipients: medical low molecular weight polyvinylpyrrolidone, distilled glycerol, sodium pyrosulfite, Tween-80, sodium hydroxide solution 0.1 M, water for injection.

1 ml - glass ampoules (5) - contour cell packaging (2) - cardboard packs.

1 ml - glass ampoules (10) - cardboard boxes.

The description of the drug is based on the officially approved instructions for use.

Pharmacological action Phenazepam

Anxiolytic (tranquilizer), benzodiazepine derivative. It has a pronounced anxiolytic, hypnotic, sedative, as well as anticonvulsant and central muscle relaxant effect.

It has a depressant effect on the central nervous system, occurring primarily in the thalamus, hypothalamus and limbic system. Enhances the inhibitory effect of gamma-aminobutyric acid (GABA), which is one of the main mediators of pre- and postsynaptic inhibition of the transmission of nerve impulses in the central nervous system.

The mechanism of action of phenazepam is determined by stimulation of benzodiazepine receptors of the supramolecular GABA-benzodiazepine-chlorionophore-receptor complex, leading to activation of GABA receptors, which, in turn, causes a decrease in the excitability of subcortical structures of the brain and inhibition of polysynaptic spinal reflexes.

Pharmacokinetics of the drug.

Distribution and metabolism

Widely distributed in the body.

Metabolized in the liver.

T1/2 is from 6 daughters. The drug is excreted mainly in the urine in the form of metabolites.

Indications for use:

Neurotic, neurosis-like, psychopathic, psychopath-like and other conditions accompanied by anxiety, fear, increased irritability, tension, emotional lability;

Hypochondriacal-senestopathic syndrome (including resistant to the action of other tranquilizers);

Prevention of states of fear and emotional stress;

Temporal and myoclonic epilepsy;

Hyperkinesis and tics;

Dosage and method of administration of the drug.

The drug should be administered intramuscularly or intravenously (stream or drip). A single dose of Phenazepam is usually 0.5-1 mg, the average daily dose is 1.5-5 mg, the maximum daily dose is 10 mg.

To relieve fear, anxiety, psychomotor agitation, as well as for vegetative paroxysms and psychotic states, the drug is prescribed in an initial dose of 0.5-1 mg (0.5-1 ml of 0.1% solution), the average daily dose is 3-5 mg (3-5 ml of 0.1 % solution), in severe cases the dose can be increased to 7-9 mg.

For epilepsy, the drug is administered intramuscularly or intravenously, starting with a dose of 0.5 mg.

For alcohol withdrawal, Phenazepam is prescribed IM or IV at a dose of 2.5-5 mg/day.

IN neurological practice for diseases with increased muscle tone, the drug is prescribed intramuscularly at 0.5 mg 1 or 2 times a day.

For preoperative preparation, the drug is administered intravenously slowly at a dose of 3-4 mg (3-4 ml of 0.1% solution).

After achieving sustainable therapeutic effect It is advisable to switch to oral dosage forms of the drug.

To avoid the development of drug dependence during a course of treatment, the duration of use of Phenazepam is 2 weeks. In some cases, the duration of treatment can be increased to 3-4 weeks. When discontinuing npenapata, the dose is reduced gradually.

Side effects of Phenazepam:

From the side of the central nervous system and peripheral nervous system: at the beginning of treatment (especially in elderly patients) - drowsiness, fatigue, dizziness, impaired concentration, ataxia, disorientation, slowed mental and motor reactions, confusion; rarely - headache, euphoria, depression, tremor, memory loss, impaired coordination of movements (especially when used in high doses), decreased mood, dystonic extrapyramidal reactions, asthenia, myasthenia, dysarthria; very rarely - paradoxical reactions (aggressive outbursts, psychomotor agitation, fear, suicidal tendencies, muscle spasms, hallucinations, anxiety, sleep disturbance).

From the hematopoietic system: leukopenia, neutropenia, agranulocytosis, anemia, thrombocytopenia.

From the outside digestive system: dry mouth or drooling, heartburn, nausea, vomiting, loss of appetite, constipation or diarrhea, impaired liver function, increased activity of liver transaminases and alkaline phosphatase, jaundice.

From the urinary system: urinary incontinence, urinary retention, renal dysfunction.

From the reproductive system: decreased or increased libido, dysmenorrhea; effect on the fetus - teratogenicity (especially the first trimester), central nervous system depression, respiratory failure, suppression of the sucking reflex in newborns whose mothers used the drug during pregnancy.

Allergic reactions: skin rash, itching.

Other: addiction, drug dependence, decreased blood pressure; rarely - visual impairment (diplopia), weight loss, tachycardia; with a sharp reduction in dose or cessation of use - withdrawal syndrome.

Local reactions: phlebitis or venous thrombosis(hyperemia, swelling or pain at the injection site).

Contraindications to the drug:

Angle-closure glaucoma ( acute attack or predisposition);

Severe COPD (possibly worsening respiratory failure);

Acute respiratory failure;

Pregnancy (especially the first trimester);

Breastfeeding period;

Children's and adolescence up to 18 years of age (safety and effectiveness have not been determined);

Hypersensitivity to benzodiazepines.

The drug should be used with caution in case of liver and/or renal failure, cerebral and spinal ataxia, hyperkinesis, tendency to abuse psychotropic drugs, organic diseases of the brain (paradoxical reactions are possible), hypoproteinemia, depression, and in elderly patients.

Use during pregnancy and lactation.

During pregnancy, Phenazepam is used only for health reasons. The drug has toxic effect on the fetus and increases the risk of developing birth defects when used in the first trimester of pregnancy. Application therapeutic doses in more late dates pregnancy can cause depression of the central nervous system of the newborn. Chronic use of Phenazepam during pregnancy may cause withdrawal syndrome in the newborn.

Use of the drug immediately before or during childbirth can cause respiratory depression in the newborn, decreased muscle tone, hypotension, hypothermia, and weakened sucking ("flaccid baby" syndrome).

Special instructions for the use of Phenazepam.

Particular caution is required when prescribing Phenazepam for severe depression, since the drug can be used to realize suicidal intentions.

The drug should be used with caution in elderly and debilitated patients.

For renal/liver failure and long-term treatment monitoring of the peripheral blood picture and liver enzyme levels is necessary.

The frequency and nature of side effects depend on individual sensitivity, dose and duration of treatment. When reducing doses or stopping use of Phenazepam, side effects disappear.

Like other benzodiazepines, Phenazepam has the potential to cause drug dependence in long-term use V large doses(> 4 mg/day).

At sudden cessation When using the drug, withdrawal symptoms may occur, especially when using the drug for more than 8-12 weeks.

Phenazepam enhances the effect of alcohol, so drinking alcohol during treatment with the drug is not recommended.

Use in pediatrics

Children, especially young children, are very sensitive to the CNS depressant effects of benzodiazepines.

Impact on the ability to drive vehicles and operate machinery

Phenazepam is contraindicated during work for transport drivers and other persons performing work that requires quick and accurate reactions.

Drug overdose:

Symptoms: with moderate overdose - increased therapeutic effect and side effects; with a significant overdose - pronounced depression of consciousness, cardiac and respiratory activity.

Treatment: monitoring the vital functions of the body, maintaining respiratory and cardiovascular activity, symptomatic therapy. Strychnine nitrate is recommended as an antagonist of the muscle relaxant effect of Phenazepam (injections of 1 ml of 0.1% solution 2-3 times a day). Flumazenil (Anexat) can be used as a specific antagonist: 0.2 mg IV (if necessary, the dose can be increased to 1 mg) in a 5% glucose solution (dextrose) or 0.9% sodium chloride solution.

Interaction of Phenazepam with other drugs.

When simultaneous use of Phenazepam with other drugs that cause depression of the central nervous system (including hypnotics, anticonvulsants, antipsychotics), the mutual enhancement of their action should be taken into account.

When phenazepam is used simultaneously with levodopa in patients with parkinsonism, the effectiveness of the latter is reduced.

With simultaneous use of Phenazepam with zidovudine, the toxicity of the latter may increase.

When phenazepam is used simultaneously with inhibitors of microsomal oxidation, the risk of developing the toxic effects of phenazepam increases.

When Phenazepam is used simultaneously with inducers of microsomal liver enzymes, the effectiveness of Phenazepam is reduced.

With simultaneous use of Phenazepam with imipramine, the concentration of the latter in the blood serum increases.

When using phenazepam simultaneously with antihypertensive drugs the severity of the antihypertensive effect may be enhanced.

With simultaneous use of Phenazepam with clozapine, increased respiratory depression may occur.

Terms of sale in pharmacies.

The drug is available with a prescription.

Terms of storage conditions for the drug Phenazepam.

List B. The drug should be stored out of the reach of children, protected from light. Shelf life - 2 years.

note

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The material is published for informational purposes only and under no circumstances can it be considered a substitute for medical consultation with a specialist in a medical institution. The site administration is not responsible for the results of using the posted information. For questions of diagnosis and treatment, as well as prescribing medications and determining their dosage regimen, we recommend that you consult a doctor.

Phenazepam - a medicine against negative emotions

Phenazepam is the first tranquilizer that was developed by Soviet pharmacists. Its task is to influence the central nervous system to help it cope with various critical situations. Phenazepam relieves any emotional stress, be it fear, panic or anxiety, depression or depression. It is able to put a person to sleep or reduce the degree of irritability, relax the body muscles and neutralize cramps.

However, this medicine can negatively affect a person’s memory, as well as cause a number of other side effects, so before taking it, you need to understand how Phenazepam works.

Effect of the drug

The action of Phenazepam is due to the work of the main substance of the same name, which depresses the nervous system, suppresses nerve impulses, and inhibits physical and emotional reactions to stimuli external environment. As a result, the person regains emotional balance and deep sleep.

The drug is taken orally in the form of tablets, and is also administered intramuscularly - by injection, and intravenously - through droppers. Phenazepam begins to act approximately 30 minutes after administration, but it will take quite a long time to be eliminated from the body - within several days.

Indications for use of Phenazepam

Phenazepam is believed to be very popular among drug addicts due to its relaxing properties. Doctors confirm that the drug really belongs to the group of narcotic substances and can cause harm if taken for other than medical reasons and in violation of dosage standards. Meanwhile, there are clear instructions on what Phenazepam helps with.

This medicine is indicated for the following psycho- and physiological problems:

epilepsy;
problems falling asleep, as well as restless, interrupted sleep;
suspiciousness, including in relation to the state of one’s health, expressed to an extreme degree;
unstable mood for no obvious reason, irritability, anxiety, unreasonable fear, phobias, psychosis and other neurotic conditions;
nervous tics and impaired coordination of movements;
vegetative-vascular dystonia;
various types of disorders associated with alcohol withdrawal.

Doctors also traditionally prescribe Phenazepam for depression and other mental disorders Oh.

Consequences of using Phenazepam

Phenazepam is a potent drug. Its dosage, as well as the duration of use, must be strictly controlled, otherwise the consequences of using Phenazepam will affect both physical and mental health. psychological state patient. However, even with strict adherence to medical recommendations, people taking Phenazepam may experience unhealthy manifestations in the form of:

drowsiness;
hallucinations;
inhibition of reactions;
substitution of emotions - from positive at the initial stage of taking the drug to negative in the future;
thoughts about suicide;
memory impairment;
addiction, developing into addiction, against the background of which nervous disorders can occur.

It turns out that the incorrect use of Phenazepam will lead to consequences that the patient wanted to get rid of at one time. That is, what Phenazepam affects, it can both cure and destroy new strength. The task of doctors and the patient is not to fall into this vicious circle.

Attention! We must not forget about serious consequences taking the medicine in the form of death, which is possible if you combine it with alcohol.

If the patient nevertheless violates the regimen, and the body becomes accustomed to Phenazepam, then it is recommended to discontinue the drug in inpatient conditions under medical supervision.

Side effects from taking Phenazepam

The side effects of Phenazepam are quite unpredictable. The likelihood and degree of their manifestation are individual and depend on the neuropsychological state of each patient. The list of negative reactions of the body includes:

decreased concentration of attention coupled with drowsiness;
headache;
dysarthria;
muscle weakness;
confused consciousness and disorientation in space;
low blood clotting;
dry mouth;
nausea and loss of appetite;
diarrhea or constipation;
skin rashes;
problems with the liver and kidneys;
increase in body temperature.

Important! An overdose of the drug leads to disturbances in speech, motor, respiratory and muscle functions.

Contraindications for the use of Phenazepam

Due to the fact that the drug is classified as a potent drug, it is not suitable for all patients. Phenazepam contraindications:

It is recommended to prescribe the drug very carefully to older people. Reviews about the use of the medicine are contradictory. Among the advantages is its affordable price, among the disadvantages are the risk of addiction and an inhibited state during treatment. Your doctor will tell you how to take Phenazepam correctly and whether it’s worth it. Self-medication is unacceptable, as it can lead to negative health consequences.

Real experience of using Phenazepam: reviews, clinical studies, instructions

Phenazepam is one of the strongest tranquilizers that has the ability to weaken anxiety, fear and depressive episode. Causes drowsiness, reduces muscle tone, and its effect is directed against cramps.

When exposed to it, the activity of impulses of the nervous system increases, the relief of symptoms of mental and neurological disorders, the excitability of subcortical brain processes decreases, reflex processes in the spinal cord are inhibited.

Phenazepam is prescribed to patients with the following diagnoses: increased nervous excitement, irritability, tension, sleep disturbance, autonomic dysfunctions, V for preventive purposes in states of fear, for the treatment of nervous tics, muscle rigidity and other similar neurological diagnoses.

The drug is also prescribed for certain types of epilepsy - temporal and myoclonic to reduce the manifestation of seizures.

Case study and instructions

From a clinical medical point of view, Phenazepam is a safe, fast-acting and sedative. With its help, many tasks are solved, for example, liquefaction painful sensations in the postoperative period.

Phenazepam is the development of Soviet scientists, the first practical experience its application was in the seventies of the last century in military medicine.

At that time, this drug was a powerful tranquilizer, sleeping pill, and anticonvulsant. Prescribed to patients with epilepsy, for anxiety and rehabilitation after long-term use alcohol.

If the medicine enters the body in pure form, then your mood can change dramatically in both positive and negative directions. In other words, a surge of strength may be caused or anger may arise.

Overdose affects normal functioning internal organs - causes tachycardia, low blood pressure, constipation, diarrhea, vomiting, dry mouth, heartburn.

The hematopoietic system can also malfunction: blood clots form, leukopenia, anemia and other diseases occur. The function of the genitourinary tract is impaired: acute renal failure, urinary incontinence or retention, decreased libido.

Duration and continuity of use leads to addiction, and in cases of abrupt withdrawal from Phenazepam, nervous system disorders, sleep disturbances, hallucinations appear, and sometimes thoughts of suicide occur.

In the UK and EU countries, this drug is used quite rarely for the purpose of treating drug addicts, so that withdrawal symptoms stop for a while or simply to normalize sleep.

This drug has a greater effect on a drug addict than on a person who is simply being treated with this medication. When interacting with alcohol, incredible energy and a desire to communicate with people for a long time appear, then this turns into aggression.

To stop taking the drug, it is best to consult a doctor, take a necessary tests and perhaps spend some time in the clinic.

Experimental research at the Moscow Research Institute

With the advent of Phenozepam treatment mental illness has become more efficient. Research from the Moscow Research Institute has shown that taking the drug for three or five days can relieve symptoms of anxiety, autonomic disorders and sleep disorders.

The problems associated with relieving the symptoms of neurological abnormalities seemed to have been resolved. However, after ten years, cases of abuse and addiction were identified due to exceeding the dose of the drug and taking it for a long time.

Therefore, since the 90s of the last century, a decision was made at the international and domestic level to limit the use of this medicine. However, in the field of minor psychotherapy, Phenazepam remains indispensable. To control the dosage taken, they began to use the form of injections.

The effect of the drug is aimed at the brain, including its cortex and cerebellum. The drug is well absorbed into the blood, and maximum concentration in the body is achieved within 1-2 hours. Discharged after 10 hours.

Studies have shown that anxiety is eliminated already in the first days of use and is fixed for about a month. In affective disorders, the effect of the drug was most significant, and in cases of vital depression it was less effective.

The product also remains indispensable and superior to analogues for sleep disorders, including sudden awakenings and insomnia.

A benzodiazepine tranquilizer is prescribed for epilepsy in combination with other drugs. The practice of doctors and patient reviews have proven that the number of seizures when taking Phenozepam is reduced by half or they disappear completely.

In the treatment of cardiovascular, pulmonary and digestive organs, the drug is small doses has a muscle relaxant, anxiolytic and anticonvulsant effect.

Phenozepam is widely used in cardiological practice for the treatment of tachycardia, cardialgia associated with panic and fear of death. With the help of the drug in the complex, the condition is maintained in case of ischemia, headache, arrhythmia. It is used in gynecology to eliminate postmenstrual tension.

All studies and experiments conducted prove that the use of the product is widespread in somatic practice. Before prescribing, it is important to study interactions with other medications. Improper use of other medications after stopping Phenazepam leads to unpleasant consequences, including depression, feelings of fear, dizziness, tremors, muscle twitching and others.

A word for patients and their relatives

Reviews from people who took Phenazepam and in which they describe their feelings after taking the drug will help clarify the situation.

With age, sleep disturbances appeared, it became impossible to just lie down and fall asleep, I tossed and turned, and in the morning I felt depressed and overwhelmed.

I felt changes in my body. I turned to a specialist and was prescribed Phenazepam. At first I didn’t even want to buy it, knowing that it was addictive to the drug, but I still had to do the first test. Now my sleep has returned to normal, I think it can still be used in small doses.

Because of family problems, I started to get nervous, I can’t do anything normally, the feeling of anxiety is annoying, and I can’t sleep at all.

A friend convinced me to go to the clinic. They prescribed a drug - Phenazepam. I didn’t believe in its miracle work, but after the first dose I felt that I began to take everything calmly. After 14 days everything returned to normal, and now I don’t take pills at all and feel great. There are, of course, exceptions, but they are rare.

Two years ago I began to suffer from anxiety, and this condition does not allow me to concentrate on the main thing. I turned to a specialist - they prescribed Phenazepam, after the first dose I fell asleep well, and the next morning I began to experience “cottonness” in my head and body. After a few days everything got better.

For two years I was tormented by feelings of fear for my life, for my work, etc. I bought Phenazepam and everything went away on the first day. This is an excellent option for depression, although harmful. What other way out is there?

The attacks of insomnia lasted about six months, everything caused irritation, so I went to see a doctor. He prescribed this medicine for me. Now I'm fine, thanks to the doctor.

The feeling of fear of contraction caused sleep disturbance and a state of depression. I took herbal decoctions, but nothing helped. I had to go to the clinic, where a specialist prescribed me Phenazepam, now I take the drug as prescribed and feel great.

While actively playing sports, I noticed that my muscles were very tense and could not relax. I consulted with a doctor, he recommended that I take this tranquilizer. After the first days of taking it I didn’t understand anything at all, then I doubled the dose. I began to fall asleep better, and my muscles relaxed.

Reviews from specialists

Phenazepam suppresses anxiety and normalizes sleep, but I do not recommend using it as a sleeping pill, because it takes a long time to be eliminated from the body.

Negative phenomena such as lethargy, lack of coordination of movements long time observed in all patients. If the respiratory system stops during sleep, the medicine should not be used.

Vitaly Z, neurologist, 21 years of experience

Excellent and most important affordable medicine out of line domestic drugs. Copes excellently with panic attacks when stopping psychomotor agitation in combination with butiferons and aliphatic drugs.

Representatives of drug control are not interested in the drug, since there is no effect on the psyche. For pensioners with sleep disorders, this is one of the best remedies.

Sergey I, general practitioner

A unique benzodiazepine drug in the domestic industry. Copes with vegetative crises, sleep disorders, stress and depressive states. Does not pose a risk of addiction.

It is released strictly according to prescription, and dosages should only be prescribed by a specialist. Cannot be used when working on machine tools, at heights, or when driving vehicles.

Summing up

The product has undeniable effectiveness in treating epilepsy, stress conditions, sleep disorders, migraines, and feelings of fear. But with an overdose, all the positive qualities change to the exact opposite, so a sharp change in mood can occur. With long-term use, dependence on the drug develops.

Before using Phenazepam, you should carefully study the instructions, which indicate side effects and contraindications, as well as study reviews from doctors and ordinary people.

Experience practical application shows that this remedy should be treated with extreme caution and should never be used without a doctor’s prescription. Therefore, experiments are inappropriate here.

This section was created to take care of those who need a qualified specialist, without disturbing the usual rhythm of their own lives.

After the divorce, I was in such a psycho-emotional state that I thought I would go crazy. Fear, anxiety, terrible tension, insomnia. I started taking phenozepam and have been like a person for a month now. I take 1 tablet 0.5 at night.

Drug addiction in last years has acquired impressive development. Using the drug Phenazepam as a drug leads to severe addiction. Symptoms of using Phenazepam appear within a few days after using the medicine. Addiction treatment becomes a lengthy process.

What is Phenazepam

Phenazepam – medicinal product- the first tranquilizer that was created in the seventies in the USSR. Initially, the drug was used as an anesthetic for surgical operations. Later, the drug began to be prescribed for the treatment of depression, epilepsy, insomnia, neuroses, and anxiety disorders.

Phenazepam has also been used in the treatment of alcoholism. This is a drug that relieves the symptoms of withdrawal syndrome - withdrawal symptoms when abruptly quitting alcohol. We are talking about tremors, convulsions, and autonomic dysfunctions.

The creation of Phenazepam became an important discovery in domestic medicine. Thanks to the advent of the drug, people with unstable mental health have the opportunity to receive prompt assistance in stabilizing complex forms of the disease.

Instructions for use of Phenazepam as a medicine

Phenazepam has a muscle relaxant effect.

Indications for use of the medicine are:

constant depression;
manifestation of uncontrollable feelings of anxiety, fear;
frequent insomnia;
the appearance of psychosis, excessive irritability;
post-traumatic syndrome.

In recent years, doctors rarely prescribe Phenazepam, giving preference to safer drugs of the new generation.

Why do drug addicts use Phenazepam?

Causing addiction and a feeling of euphoria in humans, Phenazepam has increasingly become used as a narcotic drug. Drug addicts take the drug with sleeping pills, alcohol and other drugs to enhance the effect. The availability of the drug causes the massive development of phenazepane addiction.

The effect of phenazepam on the body

The chemical compound found in Phenazepam, with the complex namezepine, is not itself a narcotic drug. The substance belongs to the group of benzodiazepines. Once in the human body, it reduces the excitability of parts of the brain. At the same time, taking Phenazepam causes severe chemical and physical dependence, like any drug.

Immediately after consumption, Phenazepam has the following effects on the human body:

reaction inhibition occurs;
visual and auditory activity decreases;
mood improves;
an unfounded positive perception of the surrounding reality appears.

The “decline” effect occurs 4-5 hours after consumption. After this, the feeling of anxiety increases, signs of depression, aggression, and anger intensify. To feel euphoria again and relieve negative feelings, drug addicts take pills again, increasing the dose of the drug each time.

The effect of taking Phenazepam

It will not be possible to hide the use of Phenazepam, any specialist will confirm this. The use of the drug will be shown with 100% accuracy by analyzing a person’s urine.

The effect of taking Phenazepam as a drug, with increasing doses, is similar to drinking alcohol.

You can determine that a person has taken an increased dose by the following signs:

Impaired coordination of movements, tremor. When walking, a person staggers and cannot control the functioning of his limbs.
Confusion. The drug addict's speech becomes incomprehensible.
Discoloration skin. The skin of an addicted drug addict becomes pale, the corners of his lips turn blue.
Lack of appetite.
Pupil dilation. There is no reaction of the pupils to light.
Drowsiness.
Arrhythmias.
Shortness of breath.
Dehydration. A whitish coating appears on the tongue, and the addicted drug addict is tormented by thirst.
Hallucinations. Uncontrollable hallucinations lead to suicidal tendencies.

Development of dependence on Phenazepam

When using Phenazepam as a drug, addiction develops rapidly - in just 10-14 days of daily use.

There are three types of addiction that the drug causes:

Chemical addiction. The human body quickly gets used to the dose of Phenazepam, and to increase the effect it is necessary to constantly increase the dose of the drug taken.
Physiological dependence. When the chemical components of the drug are removed from the body, a person experiences attacks of pain and nausea. Insomnia, convulsions, and constant tremors of the limbs appear.
Psychological withdrawal. Drug addicts who use Phenazepam perceive the drug as the only way to improve their mood, get away from problems and discomfort which the body experiences.

Prolonged and uncontrolled use of a tranquilizer causes severe addiction, and a constant increase in pill intake can lead to coma or death.

Consequences of use, overdose

Causing severe dependence when used, Phenazepam is dangerous because already 4 tranquilizer tablets are a lethal dose.

Overdose is the main and most dangerous consequence after taking Phenazepam. The state of a drug addict in case of an overdose is accompanied by acute intoxication of the body. Malaise, vomiting, dizziness, severe headaches to the point of loss of consciousness occur. With such symptoms, urgent first aid is necessary - cleansing the stomach, using any sorbent.

The consequences of an overdose can also be:

Irregularities at work of cardio-vascular system. There is difficulty breathing, asphyxia.
Operational disruptions circulatory system. Bradycardia, tachycardia, decreased blood pressure appear, and the pulse is weakly palpable.
Disorders of the central nervous system. Along with hallucinations, coordination is impaired, convulsions appear, and it is impossible to understand speech.
Renal dysfunction and genitourinary system. Often there is incontinence or urinary retention, kidney dysfunction, and lack of sexual desire.
Disturbances in the gastrointestinal tract. Heartburn, diarrhea, constipation, nausea, vomiting, and increased salivation occur.

How to cure addiction

Unfortunately, it is not possible to stop taking Phenazepam in high doses on your own. Painful withdrawal symptoms and psychological withdrawal after quitting the drug force the drug addict to return to using this tranquilizer again and again. To cure addiction, you need to contact an experienced psychologist and narcologist and receive adequate treatment.

There are several ways to treat phenazepane addiction:

Immediate, complete cessation of drug use. Such treatment is possible only in an inpatient drug treatment clinic under the supervision of qualified specialists. The danger of complete withdrawal is the risk of anaphylactic shock. Therefore, self-medication at home is unacceptable.
Gradual withdrawal. Treatment is also carried out in specialized clinics. In this case, the patient gradually reduces the dose of the drug taken, removing the chemical compounds that make up its composition from the body.
Replacement - taking analogues of drugs of a different type. By replacing the medication with a lighter type of tranquilizer that is not addictive, dependence on phenazepam is reduced and body functions are restored. Gradually, the use of tranquilizers is reduced to nothing.

Phenazepam is a medication intended for the treatment of mental disorders and a number of neuropathological diseases. The drug is a strong tranquilizer and sometimes it is simply necessary. However, using Phenazepam as a drug, with multiple increases in dose, in combination with alcohol and other drugs, you can become seriously dependent. Treatment for phenazepane addiction must necessarily take place in specialized clinics under the supervision of narcologists. The use of Phenazepam as a drug often provokes an overdose, which can be fatal.

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About 20 years ago, the drug Phenazepam was very popular. It was used to eliminate problems with falling asleep, combat convulsions, and muscle tension. The abundance of side effects in the product and the emergence of a new generation of sedatives have led to the fact that the drug is used less frequently. It is usually prescribed to inpatients, and therapy is carried out under the supervision of medical staff. If you strictly follow the instructions for use and the doctor’s recommendations, the medicine can give a good therapeutic effect at home.

Compound

The international name of the product - bromod- comes from its active component. It is a white or creamy powder consisting of small crystals that is poorly soluble in most liquids. Phenazepam tablets contain from 0.0005 to 0.0025 g of the substance. The auxiliary components are lactose, potato starch, povidone, calcium stearate and talc. 1 ml of “Phenazepam” in the form of a solution contains 0.001 g of the active substance, povidone, glycerol, sodium disulfite, polysorbate 80, sodium hydroxide and water for injection.

Release form

The sedative drug is presented in only two dosage forms. Other composition options are fake. Their use may result in unexpected results, complications, and serious adverse reactions.

The medication has the following release forms:

tablets are white flat-cylindrical elements with a chamfer. Phenazepam tablets with a concentration of 1 mg are additionally equipped with a score;
solution - liquid for intravenous or intramuscular injection. Packaged in glass ampoules of 1 ml. Available in cardboard boxes for 10 ampoules or blister packs of 5 and 10 pieces.

For hospitals, an additional packaging option for ampoules with solution is provided. This carton boxes with grids containing 50 or 100 ampoules of the drug.

pharmachologic effect

The therapeutic effect of Phenazepam classifies it as a tranquilizer. This is a powerful psychotropic drug with sedative, hypnotic, and anticonvulsant effects.

It is also able to relieve muscle tension and cause memory loss. In medicine, it is used to suppress fear, anxiety, eliminate excessive emotionality, and anxiety.

Pharmacodynamics and pharmacokinetics

The complex mechanism of action of a highly active tranquilizer gives it a number of features. All of them must be taken into account during therapy, otherwise the risks of developing side effects or a negative reaction to treatment will increase significantly. Increased caution must be exercised not only during the use of the product in the composition complex therapy, but also when used separately.

"Phenazepam" - what is it?

The creation of the tranquilizer "Phenazepam" took place in the 70s of the last century. Today, as then, it is obtained through complex chemical reactions. The product belongs to the group of benzodiazepines. According to their own therapeutic properties the medication is superior to other products in its range, as well as abenzodiazepine analogues. Initially, the drug was used in medicine to combat insomnia against the background of increased anxiety. Today it is prescribed for the treatment of depression, epileptic seizures. With its help, they improve the quality of sleep and ease the course of alcohol withdrawal.

Despite its effectiveness, the medicine is used less and less. The reason is that additional actions of Phenazepam can affect the patient’s quality of life. A one-time or course use of the drug can lead to the appearance of opposite effects - increased aggression, euphoria, tide positive emotions, severe drowsiness, irritability.

Is Phenazepam addictive?

The development of dependence on a medication is another reason for refusing its active use in medicine. Even correct or short-term use of Phenazepam can cause addiction, similar to a narcotic drug. For this reason, taking the drug for medicinal purposes should be under the strict supervision of the attending physician, subject to dosages and schedules. Systematic use of a tranquilizer threatens serious disturbances in the functioning of the body associated with disorders of the nervous system.

Why is Phenazepam dangerous?

The use of Phenazepam without a doctor’s prescription threatens the development of side effects, the emergence of drug dependence, and the exacerbation of existing problems.

With regular use of the product without mandatory breaks, the type of its effect on the body changes. At first, the medicine provokes the appearance of positive emotions, but after some time the most obvious consequence of the therapy is drowsiness. If you continue to use the medication against this background, the complacent mood is replaced by aggression, which is spurred on by negative experiences and changes the psyche.

Failure to comply with the dosage of Phenazepam risks the development of manifestations opposite to the desired effects. The patient begins to suffer from decreased sleep quality or sleep disturbances, unreasonable fear, anxiety. Possible hallucinations various forms, delusional or obsessive ideas, even suicidal thoughts.

"Phenazepam" as a narcotic drug

In its pure form, the main substance of the drug is rarely used to obtain a narcotic effect. Its chemical activity can lead to unpredictable, dangerous consequences for the body. For this reason, people with addiction prefer to use Phenazepam. After more powerful formulations, it rarely gives a feeling of euphoria, but it can relieve signs of drug withdrawal and facilitate the process of falling asleep. The ability to purchase medication according to a prescription prescribed by a doctor and the low price make this potent drug accessible to many.

After using the medicine as a narcotic, just stopping it will not be enough to return to normal life. It is best to carry out the withdrawal process under the supervision of medical professionals in a hospital setting. An outpatient therapy option developed by a narcologist is also allowed. There are several types of approach, but each of them is accompanied by a lot of unpleasant sensations and psycho-emotional pressure. Even after successful treatment, the risk of relapse remains high forever.

Pharmacodynamics of "Phenazepam"

The therapeutic properties of the drug are due to the ability of the main substance (chemical name -zepine) to have a direct effect on the parts of the central nervous system. This allows you to count on individual effects or complex effects depending on the specifics of the situation.

Types of drug action:

psychotropic – stimulation of the amygdala complex of the limbic system leads to the relief of tension, elimination of anxiety, relief of fear and anxiety. In this parameter, the medicine is superior to most analogues;
sedative - the effect on sections in the central zones of the brain stem calms the nervous system. This manifests itself in a decrease in the brightness of the reaction to stimuli. At the same time, psychomotor excitability decreases, which leads to a slower reaction speed, decreased activity, and deterioration of attention:
regulatory – influencing the functioning of the nervous system, the medicine reduces the dependence of falling asleep on psycho-emotional, external, internal stimuli;
sleeping pills – the process of falling asleep is simplified, sleep becomes deeper, longer, more productive;
muscle relaxation - inhibition of spinal-table reflexes leads to the elimination of spasm of skeletal muscles.

Separately, experts highlight the potentiating abilities of the product. Having a depressing effect on the nervous system, it enhances the effect of anesthesia, painkillers and sedatives. For this reason, the medicine is not combined with medications from these groups or therapy is carried out under the strict supervision of medical staff.

What does Phenazepam help with, acting as a muscle relaxant?

The product's ability to relieve muscle tension is actively used in the treatment of convulsive activity. Taking the drug has a complex effect on the cortex, thalamus and visceral part of the brain. At the same time, a series of chemical reactions are launched that enhance the basic effects of the product.

The listed medicinal properties, along with a decrease in psychomotor agitation, can cause inhibition of actions. Because of this, the drug is not prescribed to people whose safety and quality of work depend on the speed of reaction, attentiveness, and clarity of orientation. Sometimes taking medication leads to muscle weakness or lethargy, which also needs to be taken into account when drawing up a treatment regimen.

Pharmacokinetics of "Phenazepam"

The manufacturer has not provided data on the chemical and biological processes occurring in the body during the use of the drug solution. After the tablet form enters the digestive tract, the medication is actively absorbed by the mucous membrane. It is destroyed in the liver and excreted primarily by the kidneys. Its half-life ranges from 6 to 18 hours, which depends on the speed of metabolic processes in the body of a particular person. It takes about a week for the metabolites to be completely eliminated. This indicator may increase if kidney or liver function decreases.

How long does it take for Phenazepam to start working?

The rate at which the drug works depends on the type of dosage form used and the method of delivering the active substance to the brain. When the solution is administered intravenously, the effect appears within 3-5 minutes due to the instantaneous transport of the main component through the bloodstream. Intramuscular use the drug leads to a reaction within 10-15 minutes. Taking tablets gives the slowest development of the therapeutic effect - the first manifestations occur after 20-30 minutes, they reach their peak between one and two hours.

The latest data are especially important when using Phenazepam as a sleeping pill. For many people with insomnia, taking one tablet of the drug with a volume of active substance of 0.5 mg half an hour before bedtime can improve the quality of rest. If this approach does not work, then repeating the use of the product or increasing the dosage yourself next time is strictly prohibited.

How long does Phenazepam last?

Regardless of the type of dosage form and method of administration, the therapeutic effect of the drug lasts from 6-8 to 12 hours. It doesn't last more than a day. Despite the fact that the breakdown products of the chemical compound remain in the body for several more days, they cannot cause any clinical reactions or side effects.

How long can you take Phenazepam?

Only the attending physician can decide how long you can drink or inject Phenazepam. The duration of therapy directly depends on the type of problem, its severity, number of additional factors. Experts recommend limiting yourself to one-time use of the medication. If it is necessary to conduct a course based on tranquilizers, preference is given to less dangerous and aggressive products.

In situations where prolonged use of the drug cannot be avoided, they try to limit the treatment period to 1-2 weeks. This allows you to achieve a lasting therapeutic effect, but not lead to the development of addiction. IN in rare cases on the recommendation of a doctor and under his supervision, patients are given a tranquilizer for 1-2 months. After this, the drug should not be stopped abruptly. Withdrawal from therapy is carried out gradually by gradually reducing the dose and using special medications.

Indications for use of "Phenazepam"

The main indication for taking the medicine is the need to relieve excessive stimulation of the nervous system. These may be pathological conditions, the result of the influence of external factors, physiological characteristics or functional failures. Depending on the type of diagnosis, the dosage and schedule for taking the drug may vary significantly, so a doctor should prescribe the drug.

Indications for use of the drug:

panic attack, which is accompanied by a feeling of inexplicable fear;
anxiety disorders of various etiologies;
convulsive syndrome due to epilepsy, traumatic brain injury, infectious disease, elevated temperature bodies;
neuroses, as a result of disruption of the activity of certain parts of the brain. These conditions can manifest themselves as aggressiveness, irritability, and a feeling of anxiety. The drug is used in combination with other medications as part of complex therapy;

psychoses and other manifestations of pathological changes in the psycho-emotional background. Taking the medicine helps to cope with excessive excitability, aggression, reduces the potential risks of injury to yourself and others, and prevents new attacks;
some forms of schizophrenia, which are accompanied by psycho-emotional agitation;
VSD is a clinical picture that includes increased blood pressure, tachycardia, extreme nervous excitability, allows the use of Phenazepam to stabilize the patient’s general condition;

withdrawal syndrome due to alcohol withdrawal, which is manifested by sleep disturbances, tremors of the limbs, irritability;
phobias of various etiologies, for example, fear of flying on an airplane;
sleep problems caused by external reasons, emotional disturbances, mental disorders;
manifestations of hypochondria, which are accompanied by painful sensations, lead to the appearance of inappropriate thoughts;
nervous tic – with a low degree of effectiveness of less aggressive drugs;
preparation for surgery. In this case, the drug performs two functions at once. Firstly, it relieves a person’s emotional stress, allowing him to relax. Secondly, it enhances the effect of general anesthesia, eliminating problems during the procedure. Self-administration of medication for such purposes is strictly prohibited - all manipulations must be supervised by an anesthesiologist.

It is important to understand that Phenazepam is not an antidepressant. Taking it is not able to lift your mood. The inhibitory effect of the main component can even aggravate the clinical picture of the pathology, provoking the development of a depressed state against the background of lethargy, drowsiness, and apathy.

Contraindications for Phenazepam

The medication is included in the group potent drugs, therefore it has many prohibitions and application features. Its use leads to a change in the operating principle of certain areas of the brain. This can cause complications or even cause death.

Contraindications to taking the medication:

coma – depression of the central nervous system threatens to worsen the underlying disease and complicates the diagnosis;
shock state - accompanied by a drop in blood pressure, which under the influence of the drug can decrease even more;
myasthenia gravis - pathological muscle weakness with such therapy noticeably increases;
acute intoxication with drugs or alcohol - a combination of aggressive substances increases the risk of depression of the part of the brain responsible for breathing;
some lung diseases - conditions that are accompanied by respiratory failure, may worsen under the influence of medication;
depression, suicidal tendencies - taking Phenazepam will aggravate the manifestations of the clinical picture, increasing the risk of inappropriate actions;
acute attack of angle-closure glaucoma;
pregnancy, especially its first trimester;
breast-feeding;
age under 18 years;
allergic status, increased susceptibility to benzodiazepines.

Taking Phenazepam, even in the absence of the listed contraindications, can be dangerous if you do not follow special instructions. In old age, the basic therapeutic dose of the drug is reduced by 20-30%. During treatment, a ban on driving vehicles is introduced. Its duration ranges from a day with a single dose of the medicine to 3-4 days with its course use. It is not recommended to combine the product with drinking coffee or other tonic drinks. If the liver or kidneys are impaired, after a stroke, or against the background of hepatitis, increased caution must be exercised.

Side effects of Phenazepam

The negative consequences of taking a medication can be associated not only with its effect on the nervous system, but also with malfunctions of other internal organs. Most often the situation is limited to a decrease physical activity, drowsiness, lethargy, feeling of constant fatigue.

The summary of the drug indicates the possibility of developing the following adverse reactions:

decreased functionality of the central nervous system in the form of problems with concentration, dizziness, headaches, speech depression, coordination disorders;

You will learn about other reasons that can cause headaches from

dementia and senile dementia in people over 65 years of age;
increased manifestation of the symptoms that the treatment was aimed at combating. Very rarely this takes the form of insomnia, hallucinations, aggression, muscle spasms;
decreased libido in both sexes, erection problems in men;
a decrease in blood pressure to pathological levels with initially low numbers;
deterioration of the liver and kidneys due to the toxic effects of the main component on these organs;
changes in blood composition;
dyspeptic disorders in the form of dry mouth, loss of appetite, constipation, diarrhea, nausea;
allergic reactions of various types and severity;
drug addiction type;
weight loss;
heart rhythm disturbances.

Some consequences develop immediately after taking the product, others become the result of course therapy. The decision on the advisability of further use of the drug is made by the doctor based on signs of positive dynamics of the main treatment and the severity of adverse reactions.

"Phenazepam" - instructions for use, dosage

The inhibitory effect of the active substance of the drug on the nervous system can lead to the development of serious complications. Only if you follow the dosage schedule and select therapeutic doses of Phenazepam that are suitable for a particular case, can you count on a pronounced therapeutic effect in minimal risks negative consequences. Despite the presence of detailed instructions for the product, therapy is recommended to be carried out according to an individual plan.

Phenazepam tablets - instructions for use

Items are intended for oral use. They are swallowed with a small amount clean water. Depending on the diagnosis, 1.5-5 mg of the active substance is recommended per day, divided into 2-3 approaches. A single dose of the drug taken at night should be greater than the standard daily dose. Regardless of the type of disease and goals of therapy, the maximum daily dose of the drug is 10 mg of the main component. To avoid a negative response from the digestive system, the medication should be taken 30-60 minutes after meals.

problems sleeping - 0.25-0.5 mg 30 minutes before going to bed;
neuroses, psychopathy, and similar conditions - at the initial stage, the daily dose is 1.5-3 mg. Over 2-3 days it is gradually increased to 4-6 mg;
increased anxiety, fears, pathological motor activity - the initial daily dose is 3 mg of the active substance. It is increased depending on the severity of the therapeutic effect;
epilepsy – from 2 to 10 mg per day;
withdrawal syndrome due to alcohol dependence – from 2.5 to 5 g per day;
increased muscle tone – from 2 to 6 g per day;
VSD - the first 4-5 days, 0.5-1 mg per day. If there are no side effects, the daily volume is doubled.

Solution for intravenous and intramuscular administration - instructions for use

The drug in the form of a solution is intended for intramuscular, as well as intravenous drip or jet administration. The method of administration is selected by the doctor and depends on the patient’s condition and the required speed of action of the medication. One-time, average daily and maximum dose similar to those recommended for tablet form.

Universal dosages of medication to combat various conditions:

panic attacks, attacks of excitement, anxiety - 3-5 mg per initial stages pathology, 7-9 mg for severe clinical picture;
convulsive seizures - the starting dose is 0.5 g, it increases depending on the severity of the positive dynamics;
muscle hypertonicity due to diseases of a neurological nature - 0.5 mg up to 2 times a day;
alcohol withdrawal - the daily volume is selected individually and ranges from 2.5 to 5 mg of the active substance;
preparing the patient for surgery general anesthesia– 3-4 mg of the component are administered intravenously very slowly.

The course of drip or injection therapy should be no more than 2 weeks. IN extreme cases it is doubled, but only under the constant supervision of doctors. After achieving stable positive dynamics, patients are usually transferred to tablets.

Consequences of an overdose of Phenazepam

Exceeding therapeutic doses of the drug is dangerous to human health and life. For this reason, it can only be taken under the supervision of a doctor. The medicine is stored in places inaccessible to children. Even a slight overdose of Phenazepam and its analogues can lead to the development of significant side effects, which usually affect the activity of the nervous system. To the list of possible symptoms include drowsiness, speech problems, inhibited reaction, tremors of the limbs, dizziness due to a drop in blood pressure, bradycardia.

Significantly exceeding the permissible dose of the product can lead to death. Usually it becomes a consequence of respiratory or cardiac arrest due to inhibition of the centers in the brain responsible for these functions. The volume of a lethal dose of medication varies from person to person. The indicator also depends on the method of taking the medicine - intravenous administration is characterized by increased risks. The likelihood of human death increases when mixing the product with alcoholic beverages.

Attempts to cope with the consequences of an overdose of Phenazepam on your own threaten to worsen the situation. If alarming signs appear, you must immediately call ambulance. The specialist will inject the victim with one of the original antidotes of the medication to neutralize its effect. The drugs Anexat or Flumanesil are capable of blocking receptors, due to irritation of which the pharmacological effect of the tranquilizer is ensured. Additionally, symptomatic therapy is carried out aimed at restoring the functioning of the heart and lungs and preventing coma.

Interaction

The increased chemical and biological activity of Phenazepam should be taken into account when carrying out complex therapy. The simultaneous use of a medicine with products that affect brain activity can lead to unexpected consequences. In some cases, this increases the likelihood of side effects and overdose.

The results of combining a medication with others medicines:

nootropics (“Phenibut”) – mutual enhancement of properties and effects, requiring a reduction in therapeutic doses;
antidepressants (“Fluoxetine”, “Amitriptyline”) - the hypnotic and sedative effects of the tranquilizer are enhanced;
tranquilizers (“Afobazol”) – mutual enhancement of properties;

You can find detailed instructions for Afobazole in this

anticonvulsants (“Finlepsin”) – the anticonvulsant activity of both products increases;
sedatives (“Corvalol”) – the hypnotic and sedative effects are mutually enhanced;
narcotic analgesics (“Tramadol”) – the analgesic effect becomes more pronounced;
sleeping pills (“Sonapax”, “Donormil”) – a multiple increase in pharmacological effects;
hypotensive (“Capoten”) – blood pressure decreases even more actively;
antiviral (“Zidovudine”) – the toxicity of the product intended to combat pathogens increases;
stimulants (drugs with caffeine) – the strength of the tranquilizer is reduced.

In the case of some drugs, the interaction of the chemical components does not manifest itself in any way. In particular, Phenazepam does not affect the effectiveness of most antibiotics; its properties are also not affected.

Terms of sale

The drug is included in List B. It cannot be purchased at a pharmacy without a prescription written in Latin by the attending physician.

Storage conditions

The product should be kept out of the reach of children and protected from sun rays place. The air temperature should not exceed 25°C.

Best before date

The medicine must be used within 3 years from the date of manufacture. After that he therapeutic effect decreases and toxicity increases.

How to replace Phenazepam

Pharmacies offer a lot of benzodiazepine derivatives that act as analogues of Phenazepam. At the same time, a significant part of these products pose less danger to the patient, despite the similarity of action, the presence of contraindications and adverse reactions. The most common are: Nozepam, Diazepam, Lorafen, Grandaxin. The doctor may also offer the patient Phenobarbital or Atarax.

It is necessary to be able to distinguish an analogue of “Phenazepam” from its synonym. The latter include Fenzitat, Fezanef, Phenorelaxan, Elzepam and a number of other drugs. They all have similar active component, but are sold under different trade names.

Phenazepam and alcohol

The simultaneous use of medicine with alcohol is dangerous for human health and life, regardless of the volume of the components. Their combination increases each other's toxicity, increases the risk of adverse reactions, and leads to inhibition of the activity of vital centers of the central nervous system. Even in minimal doses, such a complex of substances causes dizziness, increased fear, sweating, and confusion. In some cases, people experience hallucinations and become suicidal.

It is strictly forbidden to use the drug to fall asleep against the background of alcohol intoxication. Drug-induced sleep can lead to complications such as choking on vomit, retrograde amnesia, and involuntary bowel movements. Bladder and intestines. Against this background, there is a high risk of respiratory arrest or an attack of suffocation. Even if the victim receives timely medical care, there is a possibility of irreversible changes in his brain.

"Phenazepam" during pregnancy and lactation

The use of the product for the treatment of pregnant or lactating women is possible only for medical reasons with the permission of a doctor and if it is impossible to select less dangerous analogue. The effect of the active substance of the drug on the fetus’s body threatens the child with developmental defects if it is used in the first trimester. IN last weeks Over time, the aggressive component can provoke depression of important parts of the central nervous system in the child’s brain. In a newborn, this will manifest itself in the form of muscle weakness, weakened reflexes, hypothermia, and breathing problems. Long-term use of a tranquilizer by a pregnant woman threatens the development of physical dependence from the drug in a child.

The active component of the drug can pass into breast milk, so it is not compatible with lactation. Getting into children's body, the substance partially disintegrates, accumulating in tissues. This leads to the development of a pronounced sedative effect, which provokes weight loss in the infant due to lack of appetite.

Phenazepam is a highly active tranquilizer, has anxiolytic, anticonvulsant, central muscle relaxant and sedative effects.

The tranquilizing and anti-anxiety effect is superior in strength to the analogues of Phenazepam. The drug also has an anticonvulsant and hypnotic effect. The anxiolytic effect of the drug is expressed in reducing emotional stress, easing fear, anxiety and restlessness.

In this article we will look at why doctors prescribe the drug Phenazepam, including instructions for use, analogues and prices for this drug in pharmacies. If you have already used Phenazepam, leave your feedback in the comments.

Composition and release form

Clinical and pharmacological group: tranquilizer (anxiolytic). "Phenazepam" is produced in the form of tablets and solution for injection.

One tablet contains 2.5 mg, 1 mg or 0.5 mg of phenazepam (active ingredient).

One package contains fifty tablets. The drug solution is available in glass ampoules, each with a volume of 1 ml. A pack may contain 100, 50 or 10 glass ampoules of different concentrations: with a three percent or 0.1% solution.

What is Phenazepam used for?

Most often, the medication is used as a tranquilizer - it eliminates convulsive activity, tremors, hyperkinesis, etc. The drug interacts with benzodiazepine receptors of the GABAergic complex, as a result of which the inhibitory effect of GABA is enhanced, neuronal activity and descending effects on the spinal cord are reduced.

Most often, the remedy helps with the following conditions:

Various neurosis-like conditions combined with anxiety or fears;
As a sleeping pill;
Conditions requiring immediate relief from feelings of obsessive fear;
A sedative for persistent depression of mood;
Phobias of various origins and different gravity;
An aid in preparing patients for surgery;
Suppressing withdrawal syndrome in patients suffering from alcohol dependence;
Convulsions varying degrees heaviness;
Treatment of epileptic seizures;
Panic reactions associated with nervous excitement.

pharmachologic effect

Anxiolytic (tranquilizer), benzodiazepine derivative. It has a pronounced anxiolytic, hypnotic, sedative, as well as anticonvulsant and central muscle relaxant effect.

The mechanism of action of phenazepam is determined by stimulation of benzodiazepine receptors of the supramolecular GABA-benzodiazepine-chlorionophore-receptor complex, leading to activation of GABA receptors, which, in turn, causes a decrease in the excitability of subcortical structures of the brain and inhibition of polysynaptic spinal reflexes.

Instructions for use

The drug should be taken orally. A single dose of Phenazepam is usually 0.5-1 mg. The average daily dose of Phenazepam is 1.5 – 5 mg, it is divided into 2-3 doses: usually 0.5-1 mg in the morning and afternoon, at night – up to 2.5 mg. The maximum daily dose of Phenazepam is 10 mg.

For alcohol withdrawal, Phenazepam is prescribed at a dose of 2.5-5 mg/day.
In case of severe agitation, fear, anxiety, treatment begins with a dose of 3 mg/day, quickly increasing the dose until a therapeutic effect is obtained.
For sleep disorders, the drug should be used in a dose of 0.25-0.5 mg 20-30 minutes before bedtime.
For epilepsy, the dose is 2-10 mg/day.
For diseases with increased muscle tone, the drug is prescribed 2-3 mg 1-2 times a day.
For neurotic, psychopathic, neurosis-like and psychopath-like conditions, the initial dose of the drug is 0.5-1 mg 2-3 times a day. After 2-4 days, taking into account the effectiveness and tolerability of the drug, the dose can be increased to 4-6 mg/day.

To avoid the development of drug dependence during a course of treatment, the duration of use of Phenazepam is 2 weeks. In some cases, the duration of treatment can be increased to 2 months. When discontinuing npenapata, the dose is reduced gradually.

Contraindications

Like any medicine, Phenazepam has a number of contraindications. You should strictly follow them and not take pills or injections, otherwise there is a high probability of causing great harm to the body.

The drug should not be used in the following cases:

Severe poisoning with alcoholic beverages, in which there is an immediate danger to life.
Poisoning with sleeping pills, sedatives, drugs.
Chronic obstructive pulmonary disease.
Severe depression accompanied by suicidal tendencies.
Acute respiratory failure.
Hypersensitivity to the components of the drug.
Minority (the safety of the drug for children has not been tested).
Pregnancy (especially the first trimester);
Breastfeeding period;
In case of liver and kidney failure, phenazepam should be taken with extreme caution.

Side effects

A large list of contraindications indicates the presence of an even larger list of side effects:

Severe fatigue and lethargy, constant drowsiness;
Clouding of consciousness and reason;
Frequent tachycardia;
Irritation of the skin, possible severe itching and rash;
Drug dependence;
Inhibition of human reaction;
A sharp decrease in blood pressure;
Significant weight loss;
Lack of concentration;
Loss of a person in space;
Double vision is recorded;
Causeless euphoria;
Tremor of the limbs;
Functional impairment digestive tract, constipation and diarrhea are most often observed;
In addition, the following may occur:
Impaired pronunciation caused by damage to the central nervous system;
Forgetfulness, memory lapses;
Strong and frequent pain in the head;
The person is in a bad mood;
Frequent dizziness;
Gagging, nausea, painful vomiting;
Anemia;
Dry mucous membranes;
Decreased libido;
Appetite decreases;
Heartburn appears.

Overdose

Using the drug, the patient may receive an overdose of Phenazepam. Symptoms of an overdose of Phenazepam are as follows: decreased reflexes, severe drowsiness, tremor, nystagmus, prolonged dysarthria. Shortness of breath or difficulty breathing, bradycardia may occur. Sometimes an overdose of Phenazepam can cause a coma and a decrease in blood pressure in the patient.

In case of overdose of Phenazepam it is necessary to use Activated carbon, perform gastric lavage, administer flumazenil (this is done in a hospital). In any case, in case of an overdose of the drug, you should urgently call a doctor.

Pregnancy and lactation

During pregnancy, Phenazepam is used only for health reasons. The drug has a toxic effect on the fetus and increases the risk of birth defects when used in the first trimester of pregnancy.

The use of therapeutic doses in later stages of pregnancy may cause depression of the central nervous system of the newborn. Chronic use of Phenazepam during pregnancy may cause withdrawal syndrome in the newborn.

Interaction with other drugs and alcohol

The drug Phenazepam ІС enhances the effect of narcotic, sleeping pills, anticonvulsants, as well as ethyl alcohol. Phenazepam should not be taken together with monoamine oxidase inhibitors, barbiturates and phenothiazine derivatives, due to mutually enhancing effects.

It is forbidden to take alcoholic beverages during treatment with Phenazepam ІС, as the drug enhances the effect of alcohol

Withdrawal syndrome. addictive

Like other benzodiazepines, it has the ability to cause drug dependence when taken long-term in large doses (more than 4 mg/day). If you suddenly stop taking it, you may experience a “withdrawal” syndrome (depression, irritability, insomnia, increased sweating, etc.), especially with long-term use (more than 8-12 weeks).

If patients experience such unusual reactions as increased aggressiveness, acute states of agitation, feelings of fear, thoughts of suicide, hallucinations, increased muscle cramps, difficulty falling asleep, shallow sleep, treatment should be discontinued.

Phenazepam analogs

Analogs of Phenazepam based on the active substance are Fezanef, Fesipam, Elzepam, Phenorelaxan, Tranquesipam. When replacing Phenazepam it medicinal analogues consultation with a doctor is required.

Prices

The average price of Phenazepam in pharmacies (Moscow) is 90 rubles.

Storage conditions

Phenazepam is included in List B. It is recommended to store it in a dry place, protected from sunlight and out of reach of children, at a temperature of no more than 25°C.

Shelf life: the drug can be used within 36 months from the date of manufacture.

Phenazepam is a drug from the benzodiazepine group. Suppresses the activity of the central nervous system, specifically affecting brain structures such as the thalamus and hypothalamus, as well as the limbic system.

Together with gamma-aminobutyric acid (GABA), it enhances pre- and postsynaptic inhibition of the transmission of nerve impulses. Activation of GABA receptors consists of stimulation by phenazepam of the GABA-benzodiazepine-chlorionophore prescription complex of benzodiazepine receptors.

As a result, the sensitivity of GABA receptors to this mediator increases, thereby enhancing the inhibitory effect of GABA on the central nervous system. At the psychological level, the patient experiences a decrease in emotional stress, restlessness, anxiety, glimpses of a positive attitude, depression and obsessive fears go away.

The central muscle relaxant effect is due to inhibition of polysynaptic spinal afferent inhibitory pathways (to a lesser extent, monosynaptic ones). Direct inhibition of motor nerves and muscle function is also possible.

Phenazepam is a highly active tranquilizer, has anxiolytic, anticonvulsant, central muscle relaxant and sedative effects. The tranquilizing and anti-anxiety effect is superior in strength to the analogues of Phenazepam. The drug also has an anticonvulsant and hypnotic effect. It has virtually no effect on affective, hallucinatory and acute delusional disorders.

When taken orally, the drug is well absorbed from the gastrointestinal tract. Cmax of phenazepam in the blood is from 1 to 2 hours. Metabolized in the liver. T1/2 is from 6 to 18 hours. The drug is excreted mainly in the urine.

Indications for use

What does Phenazepam help with? The drug is prescribed for the following diseases or conditions:

Psychopathic-like, psychopathic, neurosis-like, neurotic and other conditions that are accompanied by emotional lability, tension, increased irritability, fear, anxiety;
Vegetative lability;
Reactive psychoses;
Muscle stiffness;
Hypochondriacal-senestopathic syndrome;
Tics and hyperkinesis;
Autonomic dysfunctions;
Myoclinic and temporal lobe epilepsy;
Sleep disorders;
Prevention of emotional stress and fear.

Recommended as a means to overcome fear and emotional stress in extreme situations. In schizophrenia, with high sensitivity to antipsychotic medications. Used for resistance to various tranquilizers.

Instructions for use of Phenazepam and dosage

Phenazepam injections intramuscularly or intravenously (stream or drip): for rapid relief of fear, anxiety, psychomotor agitation, as well as for vegetative paroxysms and psychotic states, initial dose – 0.5-1 mg (0.5-1 ml of 0.1% solution) , the average daily dose is 3-5 mg, in severe cases - up to 7-9 mg.

Orally: for sleep disorders – 0.25-0.5 mg 20-30 minutes before bedtime.

For the treatment of psychopathic, neurosis-like and psychopath-like conditions, the initial dose is 0.5-1 mg 2-3 times a day. After 2-4 days, taking into account the effectiveness and tolerability, the dose of Phenazepam can be increased to 4-6 mg/day.

In neurological practice, for diseases with increased muscle tone, the drug is prescribed intramuscularly at 0.5 mg 1 or 2 times a day.

In case of severe agitation, fear, anxiety, treatment begins with a dose of 3 mg/day, quickly increasing the dose until a therapeutic effect is obtained.

For epilepsy, Phenazepam is administered by injection IM or IV, starting with a dose of 0.5 mg.

For the treatment of alcohol withdrawal - orally, 2-5 mg/day or intramuscularly, 0.5 mg 1-2 times a day, for vegetative paroxysms - intramuscularly, 0.5-1 mg.

The average daily dose is 1.5-5 mg, divided into 2-3 doses, usually 0.5-1 mg in the morning and afternoon and up to 2.5 mg at night. In neurological practice, for diseases with muscle hypertonicity, 2-3 mg is prescribed 1 or 2 times a day.

The maximum daily dose is 10 mg. To avoid the development of drug dependence during a course of treatment, the duration of use of Phenazepam is 2 weeks (in some cases, the duration of treatment can be increased to 2 months).

Phenazepam in tablet form is prescribed for oral administration in hospital settings daily dosage the drug is up to 4 mg, for therapy convulsive conditions for epilepsy, the dose is increased to 9 mg. At outpatient treatment up to 0.5 mg of the drug is prescribed once a day.

In order to relieve alcohol withdrawal, the patient is prescribed 5 mg of medication per day. For the treatment of sleep disorders - 1 mg half an hour before rest. The maximum daily dose should not exceed 10 mg.

In case of severe agitation, fear, anxiety, treatment begins with a dose of 3 mg/day, quickly increasing the dose until a therapeutic effect is obtained.

When discontinued, the dose is reduced gradually. During the course of treatment, alcohol consumption is prohibited!

Contraindications

The use of Phenazepam is contraindicated in the following cases:

Coma;
Myasthenia;
COPD (possible increased respiratory failure);
Severe form of depression;
Angle-closure glaucoma;
Analgesic poisoning or acute alcohol poisoning;
Acute respiratory failure;
I trimester of pregnancy;
Children under 18 years of age;
During lactation;
Intolerance to benzodiazepines.

Prescribe with caution when:

Liver and/or renal failure, cerebral and spinal ataxia, history of drug dependence;
Tendency to abuse psychoactive drugs;
Organic brain diseases, psychosis (paradoxical reactions are possible), hypoproteinemia;
Sleep apnea (known or suspected);
Elderly patients.

Side effects

At the beginning of treatment, especially in elderly patients, the following may develop:

drowsiness, feeling tired, dizziness, impaired concentration, ataxia, disorientation, slowed mental and motor reactions, confusion;
rarely - headache, euphoria, depression, tremor, memory loss, impaired coordination of movements (especially when used in high doses), decreased mood, dystonic extrapyramidal reactions, asthenia, myasthenia, dysarthria;
very rarely - paradoxical reactions (aggressive outbursts, psychomotor agitation, fear, suicidal tendencies, muscle spasms, hallucinations, anxiety, sleep disturbance).

Other side effects:

leukopenia, neutropenia, agranulocytosis;
anemia, thrombocytopenia;
dry mouth or drooling, heartburn, nausea, vomiting, decreased appetite, constipation or diarrhea;
impaired liver function, increased activity of liver transaminases and alkaline phosphatase, jaundice;
urinary incontinence, urinary retention, renal dysfunction;
decreased or increased libido, dysmenorrhea;
effect on the fetus - teratogenicity (especially the first trimester), central nervous system depression, respiratory failure, suppression of the sucking reflex in newborns whose mothers used the drug during pregnancy;
skin rash, itching;
addiction, drug dependence, decreased blood pressure;
phlebitis or venous thrombosis (hyperemia, swelling or pain at the injection site).

Overdose

In case of an overdose of Phenazepam, all side effects may increase, as well as disruption of breathing and heart rhythm.

The antidote is strychnine nitrate or flumazenil. Treatment is symptomatic.

Pregnancy and lactation

Phenazepam is contraindicated for use at any stage of pregnancy and during breastfeeding.

Drug interactions

Simultaneous use with Levodopa drugs leads to a decrease in the therapeutic effect of the latter;
Concomitant use with Imipramine leads to an increase in the plasma concentration of the latter;
Concomitant use with Zidovudine leads to increased toxicity of the latter;
Simultaneous use with antiepileptic drugs, hypnotic drugs, narcotic substances, drugs containing ethanol or alcoholic beverages, leads to a sharp increase in the therapeutic effect of the latter;
When used simultaneously with Clozapine, there is an increase in side effects associated with respiratory depression.

Phenazepam analogues, list of drugs

If necessary, you can replace Phenazepam with similar drugs, list:

Tranquesipam
Fesipam
Phenazepam-Ros
Phenorelaxan
Elzepam

When choosing analogs, it is important to understand that the instructions for use of Phenazepam, price and reviews do not apply to drugs with similar effects. It is important to consult a doctor and not change the drug yourself.

The average price in pharmacies is 497-520 rubles.

Store in a place protected from light and out of reach of children at a temperature not exceeding +25°C. Shelf life – 3 years.