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Unidox solutab for angina dosage for adults. Medicinal reference book geotar

Unidox Solutab (Unidox Solutab).

International Nonproprietary Name (INN)

Doxycycline.

Pharmacological group

Unidox Solutab belongs to the group antibiotics tetracycline series.

Compound

One Unidox tablet contains doxycycline monohydrate in an amount equal to 100 mg of pure doxycycline - this is the active substance of Unidox Solutab tablets. Excipients:

The tablets are packaged in plastic blisters of 10 pieces, one in a cardboard box.

Release form

The drug Unidox Solutab is available in the form of dispersible (soluble) biconvex round tablets. The color can be different shades of yellow. A notch is visible on one side of the tablet, and “173” is engraved on the other.

pharmachologic effect

Doxycycline, which is part of Unidox, is a substance that stops the proliferation of bacterial cells, which is associated with a violation of protein formation in the cells of microorganisms.

This drug belongs to the group of antibiotics wide range action, but it should be noted that many microorganisms have now become insensitive to this antibiotic.

In our time, the most sensitive to Unidox among gram-positive cocci are pneumococcus, most enterococci and some groups of staphylococci, and among gram-negative cocci - moraxella and meningococcus. Most gonococci are insensitive.

Doxycycline is active against leptospira, rickettsia, spirochetes, chlamydia, borrelia, mycoplasma, some protozoa and actinomycetes.

The destructive effect of doxycycline has been established against certain types of gram-positive and gram-negative bacilli: yersinia, listeria, brucella, vibrios (including cholera), pathogens of plague, granuloma inguinale, tularemia, anthrax.

Salmonella, Enterobacter, Escherichia coli, Klebsiella, Shigella are resistant to doxycycline.

From anaerobic microorganisms Fusobacteria, clostridia, and propionibacteria (P. acnes) are susceptible to the action of doxycycline.

Pharmacokinetics

When taken orally, it is perfectly absorbed, and its absorption and effect in the body does not depend on food intake. In the period from an hour to 3 hours after taking the drug, the maximum concentration of doxycycline is recorded in the blood. This drug also creates a fairly high concentration of doxycycline in the tissues. IN cerebrospinal fluid the level of the drug is 25% higher than in the blood, in bile – 20%. The drug is able to cross the placenta to the fetus and enter breast milk. Excreted from the body through gastrointestinal tract. The period during which exactly half the dose is eliminated from the body taken drug, is equal to 20 hours.

Application

Found the drug Unidox Solutab wide application in the treatment of diseases such as:

STIs (sexually transmitted infections) – gonorrhea, syphilis, lymphogranuloma venereum, granuloma inguinale;
chlamydial infections - trachoma, urethritis, cervicitis, psittacosis, prostatitis;
mycoplasma infections;
rosacea (rosacea);
acne;
borreliosis – relapsing fever, Lyme disease;
bacterial zoonotic infections – tularemia, plague, brucellosis, anthrax, leptospirosis;
rickettsiosis;
infections of the lower respiratory tract– community-acquired atypical pneumonia, chronic bronchitis in the acute stage;
gynecological infectious diseases– salpingoophoritis, adnexitis, endometritis;
actinomycosis;
acute dacryocystitis;
intestinal infectious diseases – yersiniosis, cholera;
animal bites complicated by wound infection;
cat scratch disease;
prevention of tropical malaria.

Contraindications

childhood up to 8 years;
severe liver pathology;
pregnancy;
lactation period.

Instructions for use

Pimples (acne, acne vulgaris, rosacea)

In case of intolerance and ineffectiveness local treatment acne, in severe and moderate cases of the disease (including scarring), systemic antibiotic therapy is prescribed. In this case, the antibiotic Unidox is the drug of choice. Take 100-200 mg of the drug, dividing the dose into 2 doses. The duration of treatment is 12 days.
Ureaplasmosis
Treatment of ureaplasmosis is carried out by taking 100 mg of the drug Unidox twice a day with a 12-hour break, for 7 days.

Chlamydia
For the treatment of urogenital chlamydia, Unidox is taken 100 mg twice a day for a week.

Prostatitis
The duration of treatment of bacterial prostatitis with Unidox at a daily dose of 200 mg is at least 4 weeks. The drug is taken in two doses, 12 hours apart.

Syphilis
If you are intolerant to antibiotics penicillin series In the treatment of syphilis, reserve antibiotics are used, one of which is Unidox Solutab. For preventive treatment, the drug is prescribed 3 times a day, 100 mg, for 2 weeks. For the treatment of fresh forms, the period of use of the drug at the same dose is increased to 20-25 days.

Gonorrhea
Uncomplicated subacute and sharp forms Gonorrhea can be treated with Unidox Solutab. Tablets are taken orally at 100 mg (the first dose is 200 mg) every 12 hours, the total dose of treatment is 1000 mg. For other forms of gonorrhea, treatment is carried out according to the same scheme, but the total dose per course is 1500 mg.

Granuloma
For the treatment of lymphogranuloma venereum and inguinal granuloma (donovanosis), Unidox tablets are taken for 3 weeks, 100 mg every 12 hours.

Actinomycosis
Actinomycosis can be treated with Unidox in a daily dose of 0.2 g, taken for six months to a year.

Eye diseases
Eye diseases, such as trachoma and acute dacryocystitis, are treated with Unidox for 21-28 days at a daily dose of 200 mg, in two doses.
Cholera
For cholera, 300 mg of Unidox is prescribed once.

Rickettsial disease
The treatment regimen for rickettsiosis includes prescribing Unidox 100 mg twice a day for a week (or for 2 days after normalization of body temperature).

Zoonosis
The treatment regimen for bacterial zoonoses is similar, the only differences are in the duration of drug administration. Unidox is prescribed 100 mg every 12 hours, for plague - 10 days, for tularemia - 2 weeks, for anthrax - 2 months.

Brucellosis
The treatment regimen for brucellosis also includes the administration of Unidox 100 mg twice a day, in combination with other antimicrobial drugs (streptomycin, rifampicin).

Leptospirosis
To prevent leptospirosis, take 100 mg of Unidox once a week.
For tick-borne borreliosis, take 0.1 g of the drug every 12 hours for a month. For prevention purposes, 200 mg of Unidox is prescribed once.

Malaria
When traveling to areas where malaria is endemic, you must take Unidox the day before departure, and take the drug during the entire period of your stay in this country. The total interval for taking Unidox should not exceed 6 months. The daily dose is 100 mg.
Respiratory system infections
For lower respiratory tract infections, the duration of Unidox therapy is from 7 to 10 days, for mycoplasma pneumonia - up to 3 weeks. Unidox is taken 200 mg orally once a day.

Other Applications
To prevent the development of postoperative infectious complications, after an abortion in the first trimester of pregnancy, in the presence of PID (pelvic inflammatory disease), multiple sexual partners, or a history of gonorrhea, take 100 mg of Unidox 1 hour before surgery, and 200 mg of the drug after 1.5 hours after an abortion.

For children
For children over 8 years of age, Unidox is prescribed in a daily dose of 5 mg per 1 kg of weight, but not more than 200 mg. The daily dose is divided into 2 doses.

Side effect

To unwanted reactions from the outside various organs and body systems when using the drug Unidox Solutab the following symptoms include:

The risk of developing pseudotumor cerebri increases when taking vitamin A supplements while using Unidox.

The reduced therapeutic effect of oral estrogen-containing contraceptives should also be taken into account.

special instructions

Unidox Solutab should be taken orally, preferably in a standing position, with plenty of water. This will prevent possible damage to the esophagus and irritation of the gastric and intestinal mucosa.

The drug is taken regardless of meals, but at regular intervals, without skipping or doubling the dose.

During treatment, it is necessary to refrain from exposure to the sun (under direct exposure).

Unidox can be used to treat patients with renal failure, as it is eliminated through the gastrointestinal tract.

Unidox Solutab during pregnancy

The drug penetrates the uteroplacental barrier and can contribute to severe disorders of bone tissue development in the fetus. Therefore, the use of Unidox Solutab is CONTRAINDICATED during pregnancy.

Combination with alcohol

At simultaneous administration the drug Unidox Solutab and alcohol increases their toxic effect on the liver, which can lead to the development of toxic hepatitis. Also decreasing healing effect drug. Drinking alcohol is possible only a week after completing the course of treatment with Unidox.

Analogs

Preparations with a similar active ingredient (doxycycline):

Storage conditions and periods

The drug is stored in a dry place at a temperature of 15 to 25 o C, out of reach of children.
The drug is considered fit for use within 5 years from the date of production.

Dispensing conditions in pharmacies

Buy Unidox Solutab in pharmacy chain It is possible upon presentation of a doctor's prescription for this drug.

Price

Price in Ukraine
Unidox Solutab soluble tablets can be bought in Ukraine at an average price of 68 hryvnia per pack.

Price in Russia
Dispersible antibiotic tablets Unidox Solutab 100 mg can be bought in Russia at an average price of 300 rubles per pack.

Composition and release form of the drug

Dispersible tablets round, biconvex, from light yellow or gray-yellow to brown with inclusions, with an engraving “173” (tablet code) on one side and a line on the other.

Excipients: microcrystalline cellulose - 45 mg, saccharin - 10 mg, hyprolose (low-substituted) - 18.75 mg, hypromellose - 3.75 mg, colloidal silicon dioxide (anhydrous) - 0.625 mg, magnesium stearate - 2 mg, lactose monohydrate - up to 250 mg.

10 pieces. - blisters made of PVC/aluminum foil (1) - cardboard packs.

pharmachologic effect

Semi-synthetic broad-spectrum antibiotic. It has a bacteriostatic effect by suppressing the protein synthesis of pathogens.

Active against aerobic gram-positive bacteria: Staphylococcus spp. (including strains producing penicillinase), Streptococcus spp. (including Streptococcus pneumoniae), Bacillus anthracis, Listeria monocytogenes; anaerobic bacteria: Clostridium spp.

Doxycycline is also active against aerobic gram-negative bacteria: Neisseria gonorrhoeae, Escherichia coli, Shigella spp., Salmonella spp., Enterobacter spp., Klebsiella spp., Bordetella pertussis, as well as against Rickettsia spp., Treponema spp., Mycoplasma spp. and Chlamydia spp.

Pseudomonas aeruginosa, Proteus spp., Serratia spp., and most strains of Bacteroides fragilis are resistant to doxycycline.

Pharmacokinetics

After oral administration, it is quickly and almost completely absorbed from the gastrointestinal tract. Food intake has little effect on the absorption of doxycycline. Widely distributed in tissues and body fluids. Protein binding is 80-95%. T1/2 is 12-22 hours. It is excreted unchanged in the urine (40%), but the main part of the dose is excreted unchanged in the feces due to the secretion of bile.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to doxycycline, incl. infections of the respiratory and ENT organs; gastrointestinal infections; purulent infections skin and soft tissues (including acne); organ infections genitourinary system(including gonorrhea, primary and secondary syphilis); typhus, brucellosis, rickettsiosis, osteomyelitis, trachoma, chlamydia.

Contraindications

Pregnancy, children under 8 years of age (possibility of formation of insoluble complexes with calcium in the bone skeleton, enamel and dentin of teeth), hypersensitivity to tetracyclines, porphyria, severe liver failure, leukopenia, lactation period, myasthenia gravis (for intravenous administration).

Dosage

Adults are prescribed 200 mg/day orally or intravenously (drip) on the first day of treatment, and 100-200 mg/day on subsequent days. Frequency of administration (or intravenous infusion) is 1-2 times/day. For children over 8 years of age and weighing more than 50 kg, the daily dose for oral administration or intravenous administration (drip) is 4 mg/kg on the first day of treatment. In subsequent days - 2-4 mg/kg/day, depending on severity clinical course diseases. Frequency of administration (or intravenous infusion) is 1-2 times/day. Recommended minimum time for IV infusion of 100 mg doxycycline (at concentration infusion solution 0.5 mg/ml) is 1 hour.

Maximum doses: for adults for oral administration - 300 mg/day or 600 mg/day (depending on the etiology of the pathogen); for intravenous administration - 300 mg/day.

Side effects

From the outside digestive system: nausea, vomiting, anorexia, diarrhea, constipation, dysphagia, glossitis, esophagitis, transient increase in blood levels of liver transaminases, alkaline phosphatase, bilirubin.

From the hematopoietic system: neutropenia, thrombocytopenia, hemolytic anemia.

Allergic reactions: skin rash, itching, eosinophilia; rarely - Quincke's edema, photosensitivity.

Others: increase in residual nitrogen, candidiasis, intestinal dysbiosis, discoloration of teeth in children.

Drug interactions

Drugs containing metal ions (drugs containing iron, magnesium, calcium) form inactive chelates with doxycycline, and therefore their simultaneous administration should be avoided.

When used simultaneously with barbiturates and phenytoin, the concentration of doxycycline in the blood plasma decreases due to the induction of microsomal liver enzymes, which may cause a decrease in its antibacterial effect.

It is necessary to avoid combination with penicillins, cephalosporins, which have a bactericidal effect and are antagonists of bacteriostatic antibiotics (including doxycycline).

The absorption of doxycycline is reduced by cholestyramine and colestipol (keep an interval of at least 3 hours between doses).

Due to the suppression intestinal microflora doxycycline reduces prothrombin index, which requires indirect dose adjustment.

Taking doxycycline reduces the reliability of contraception and increases the incidence of breakthrough bleeding while taking estrogen-containing oral contraceptives.

Simultaneous use of retinol helps to increase intracranial pressure.

special instructions

Use doxycycline with caution in cases of liver dysfunction. In case of impaired renal function, no dose adjustment is required.

To prevent local irritation (esophagitis, gastritis, ulceration of the gastrointestinal tract), it is recommended to take it in daytime hours with plenty of liquid, food or milk. Due to possible development photosensitivity requires limiting insolation during treatment and for 4-5 days after it.

Doxycycline solution for intravenous administration should be used no later than 72 hours after its preparation.

Pregnancy and lactation

Doxycycline is contraindicated for use during pregnancy and lactation. Doxycycline crosses the placental barrier. May cause long-term discoloration of teeth, enamel hypoplasia, suppression of fetal skeletal bone growth, and the development of fatty liver.

If necessary, use during lactation should stop breastfeeding.

Use in childhood

Doxycycline is not used in children under 8 years of age, because tetracyclines (including doxycycline) cause long-term discoloration of teeth, enamel hypoplasia and slower longitudinal growth of skeletal bones in this category of patients.

For impaired renal function

In case of impaired renal function, no dose adjustment is required.

For liver dysfunction

Contraindicated in severe liver failure. Use doxycycline with caution in cases of liver dysfunction.

Unidox Solutab instructions

Instructions for use of Unidox Solutab contain a complete description of the drug and its action: composition, indications, use in treatment, contraindications, side effects, cost, analogues and reviews.

Form, composition, packaging

The drug is produced in the form of tablets that dissolve in oral cavity and do not require swallowing. The shape is biconvex, round. The color is light yellow with a hint of grey. On one side there is a dividing line and a code inscription 173 on the other side.

The active substance Unidox Solutaba doxycycline monohydrate is supplemented with microcrystalline cellulose, lactose monohydrate, saccharin, anhydrous colloidal silicon dioxide, low-substituted hyprolose, magnesium stearate and hypromellose in the required quantity.

The packaging of the drug is a pack of cardboard, which contains a blister with ten tablets.

Storage period and conditions

The drug can be stored at temperatures ranging from 15 to 25 degrees for no more than five years. Children to storage areas medicine should not be allowed.

Pharmacology

Unidox Solutab belongs to the tetracycline group of antibiotics with a broad spectrum of action. Capable of bacteriostatic effects and inhibition of the process of cellular protein synthesis in the pathogen cell, which is due to its interaction with ribosomal subunits (30S).

The activity of the drug extends to a number of gram-negative and gram-positive anaerobes, including some protozoa.

However, when resistance occurs, which is acquired by some pathogens to active component drug, the resistance of the pathogen to any drug from this group should be taken into account.

Pharmacokinetics

Absorption of the drug, which is not affected by food intake, is rapid and occurs almost completely. Maximum concentration doxycycline reaches blood plasma within two hours after taking the tablet.

The active substance of the drug binds to plasma proteins by 90 percent, which is reversible and has good ability to penetrate tissue. The level of penetration into the cerebrospinal fluid is low and amounts to no more than 20 percent of the total concentration in the blood plasma. When liver function is maintained normal level, the drug is ten times more concentrated in bile than in plasma. Up to 25 percent of the total concentration of doxycycline is found in salivary fluid.

Penetration of doxycycline through the placental barrier and a small amount into breast milk is noted.

Dentin and bone tissue can accumulate the active substance Unidox Solutaba.

The metabolic process affects only a small part of doxycycline.

The half-life after the drug is taken orally lasts up to eighteen hours, repeated doses are eliminated over more than a day.

Slightly less than half of the dose can be excreted by the kidneys through the biologically active form, the rest is excreted through the intestines in the form of inactive chelates.

Unidox Solutab indications for use

The drug Unidox Solutab is prescribed for treatment for those patients who suffer from infectious-inflammatory diseases caused by microorganisms that are sensitive to the effects of the drug.

Infectious diseases of the respiratory tract

treatment of pharyngitis;
pleural empyema;
acute bronchitis;
lung abscess;
obstructive pulmonary disease in the acute stage;
tracheitis;
community-acquired pneumonia;
lobar pneumonia;
bronchopneumonia.

Infectious diseases of the ENT organs

treatment of otitis;
tonsillitis;
sinusitis.

Diseases of the genitourinary system of an infectious nature

treatment of cystitis;
endometritis, salpingoophoritis and endocercevitis in combination with other medications;
pyelonephritis;
bacterial prostatitis;
orchiepididymitis in acute form;
urethritis;
urogenital mycoplasmosis;
urethrocystitis.

Infectious diseases that are sexually transmitted

treatment of urogenital chlamydia;
lymphogranuloma venereum;
syphilis in those patients who cannot tolerate penicillin;
inguinal granulomas;
uncomplicated gonorrhea.

Infectious diseases of the biliary tract and digestive tract

Skin infections

treatment of wound infections as a consequence of an animal bite;
acne disease in severe form as a component of combination therapy.

Eye infections

treatment of trachoma in combination with other medications.

Other infectious and inflammatory diseases

Contraindications

Therefore, there are also contraindications to the prescription when considering the treatment option for a particular disease involving of this medicine you should pay attention to them. Unidox Solutab should not be prescribed:

if the patient has severe renal or liver dysfunction;
at high level hypersensitivity to antibiotics of this group;
porphyria;
pregnancy and lactation;
children under eight years old.

Unidox Solutab instructions for use

You can take the drug different ways: dissolve in a small amount of water to obtain a suspension, swallow, divide or chew, accompanied by a drink. It is advisable to take the medicine with food at least two hours before bedtime.

The duration of therapy is no more than ten days.

For adult patients and children after reaching eight years of age whose body weight exceeds fifty kilograms, on the first day of treatment, 200 milligrams per day in one or two doses is prescribed, then 100 milligrams per day once. When the infection has severe form You can use 200 milligrams per day daily.

When the body weight of a child over eight years of age does not reach 50 kilograms, the drug is prescribed in an average daily dose of 4 milligrams per kilogram of weight on the first day of treatment and then 2 milligrams per kilogram of weight per day. For severe infections, the first day dosage can be used daily.

Streptococcal infection

Treatment lasts up to ten days.

Gonorrhea, uncomplicated

Adults: 100 milligrams twice a day for a week or for one day of treatment 300 milligrams twice a day. The second dose should be taken an hour after the first.

Primary syphilis

100 milligrams twice a day for two weeks.

Syphilis secondary

100 milligrams twice a day for four weeks.

Uncomplicated urogenital infections

100 milligrams 2 times a day for a week of use.

Acne

100 milligrams per day. Duration of treatment is from 6 to 12 weeks.

Leptospirosis (treatment)

100 milligrams 2 times a day for a week.

Prevention

malaria: 100 mg. per day a day or two before the start of the trip, directly during the trip every day and for a month after its completion. Children over 8 years old: 2 mg/kg body weight per day. Taking the drug prophylactically should not exceed four months.
Travelers' diarrhea: 200 mg. on the first day of travel and then 100 mg. all other days. Reception should be carried out for no more than three weeks.
leptospirosis: 200 mg. once a week for the entire period of stay in an area with an unfavorable situation regarding this infection and then at the end of the stay another 200 mg.
infection during medical abortion: 100 mg. one hour before the procedure and 200 mg. upon its completion.

The maximum permissible daily dose of the drug

For an adult patient: 300 milligrams;

For a child over 8 years old (body weight more than 50 kg): 200 milligrams;

For a child after 8-12 years (body weight less than 50 kg): 4 mg/kg.

For patients suffering renal failure it is necessary to reduce the dose of the drug.

Unidox Solutab during pregnancy

During pregnancy, Unidox Solutab is contraindicated. However, if there is an urgent need to treat a woman, it is prescribed. It should be taken into account that doxycycline, as the active substance of the drug, can have very adverse effects on the development of the fetus. Therefore, it is advisable to exclude pregnancy at the time of treatment. Breastfeeding is prohibited due to the penetration of doxycycline into a woman's milk.

Unidox Solutab for children

Side effects

The effects that qualify as side effects from taking Unidox Solutab affect various systems body.

Digestive system

Patients complain of the development of dysphagia, vomiting and nausea, diarrhea, anorexia, pseudomembranous colitis, enterocolitis, esophageal ulcers, esophagitis, cholestasis and tongue staining dark color. When long-term treatment takes place, it is possible that the liver may become damaged. This is especially dangerous for patients with liver or kidney failure.

Dermatology

In the form of photosensitivity, as well as the development of exfoliative dermatitis and erythematous or maculopapular rash.

Allergy

Possible reactions such as urticaria, erythema multiforme, angioedema, anaphylactic reactions, pericarditis, serum sickness-like syndrome and red systemic lupus in the form of an exacerbation.

Hematopoiesis

Possible development of hemolytic anemia, eosinophilia, neutropenia, thrombocytopenia and decreased prothrombin activity.

Endocrine system

In those patients who have taken the drug for a long time, the thyroid gland tissue may become stained. dark brown. This phenomenon reversible.

Nervous system

There were complaints of double vision and blurred vision. There were also dizzinesses, and vestibular disorders and increased HF pressure.

Urinary system

In the form of increases in residual nitrogen in urea.

Muscle and bone system

Osteogenesis slows down, normal dental development in children is disrupted in the form of enamel hypoplasia and changes in their color.

Others

In the form of manifestations of superinfection: candidiasis, vaginitis, glossitis, proctitis, stomatitis.

Overdose

Symptoms of a drug overdose are those side effects that will intensify with harmful effects to the liver. They will manifest themselves in the form of fever, vomiting, azotemia, jaundice, increased transaminase levels and prothrombin time.

The patient should be treated with immediate gastric lavage and induction of vomiting after drinking heavily. Activated carbon and osmotic laxatives are prescribed. Hemodialysis and peritoneal dialysis are not effective.

Drug interactions

When taking doxycycline simultaneously with various medications, the following effects may occur:

combination with antacids containing magnesium, calcium, aluminum, as well as with iron preparations, sodium bicarbonate and magnesium-containing laxatives can reduce the absorption of doxycycline. Therefore, they are taken with a break of at least three hours.
The dosage of indirect anticoagulants will require adjustment, since doxycycline suppresses the intestinal microflora, which in turn leads to a decrease in the prothrombin index.
The effectiveness of bactericidal antibiotics decreases.
Reliability contraception, which contain estrogen hormones, is noticeably reduced and the risk of acyclic bleeding increases.
The plasma concentration of doxycycline will be reduced when combined with ethanol, barbiturates, carbamazepine, phenytoin, and rifampicin.
Retinol together with doxycycline affects the increase in intracranial pressure.

Additional instructions

Due to the possibility of affecting prothrombin time, the administration of the drug to those patients who suffer from coagulopathies should be carefully monitored.

The drug should be monitored in patients with impaired renal function to avoid an increase in azotemia.

Long-term treatment with the drug leads to the need to monitor laboratory blood parameters and renal and hepatic functionality.

To avoid negative consequences, it is necessary to warn the patient about limiting sun exposure in the initial period of treatment.

If diarrhea develops during treatment with the drug Unidox Solutab, the medication should be discontinued and then prescribed ion exchange resins. In particularly severe situations, it is necessary to replace the loss of fluid, proteins and electrolytes by the body and prescribe the drugs vancomycin and metronidazole.

Treatment should not be combined with medications that have an inhibitory effect on intestinal motility.

Long-term treatment is fraught with dysbacteriosis.

To reduce the likelihood of dyspeptic symptoms occurring, it is necessary to take the medication during meals.

If side effects develop in the form of dizziness, double vision and blurred vision, the patient should not drive a vehicle or engage in other activities related to technical means.

Unidox Solutab analogues

Xedocin tablets are considered an analogue of the drug Unidox Solutab.

Unidox Solutab price

The average cost of the drug in pharmacies is approximately from 300 to 330 rubles.

If there is an infection of the skin, soft tissue or organs, it is important to deal with it quickly. pathogens. Broad-spectrum antibiotics, active against many bacteria, can prevent further spread of infection. To treat inflammation of the lungs, esophagus and other organs, doctors prescribe Unidox Solutab - the instructions for use of the drug contain recommended dosages and a list of contraindications.

Unidox Solutab tablets

The drug has a bactericidal effect and is effective against streptococcus pyogenes and other microorganisms. According to the instructions, Unidox Solutab tablets can be taken orally and used for intravenous infusion, after being crushed to a powder state. The medicine is suitable for the treatment of diseases caused by microorganisms sensitive to doxycycline.

Compound

The main active ingredient of the bacteriostatic antibiotic is doxycycline. The substance inhibits protein synthesis in microbial cells. The drug is available in the form of dispersible tablets. This means that the capsule dissolves in the mouth and does not require mandatory use liquids. Composition of one Unidox Solutab tablet:

Components	Concentration in mg
Doxycycline monohydrate
Microcrystalline cellulose

Lactose monohydrate
Low-substituted hyprolose
Hypromellose
Anhydrous colloidal silica
Magnesium stearate

Pharmacodynamics and pharmacokinetics

The instructions for use indicate that the drug belongs to the group of bactericidal antibiotics. Doxycycline, which is part of it, interferes with the synthesis of microbial proteins. It interacts with the small unit of the ribosome. The bactericidal effect of Unidox Solutab appears on the 2-3rd day of administration, when the concentration active substance reaches the required level. You can take the medicine if you are infected the following types microorganisms:

A number of pathogens (Acinetobacter, Proteus mirabilis, enterococci) have acquired resistance to doxycycline, so it is useless to treat infections caused by them with tetracycline antibiotics. Food has little effect on the rate of absorption of the drug. Absorption of doxycycline reaches 100% after 2 hours of administration. The drug penetrates into the bone tissue of the teeth, kidneys, liver, spleen, prostate gland, and mucous membrane of the eye. The antibiotic is excreted through the intestines.

Unidox Solutab - is it an antibiotic or not?

The drug belongs to the group of tetracyclines. The instructions for use say that it is a synthetic broad-spectrum antibiotic. At hypersensitivity The medicine cannot be used with tetracyclines and doxycyclines. At long-term use Unidox Solutab causes the death of azobacteria, streptomycetes and bifidobacteria, so after completion of treatment the patient must take a course of enterosorbents, probiotics or prebiotics.

Indications for use

The antibiotic Unidox Solutab is prescribed to patients suffering from infectious and inflammatory diseases caused by microorganisms sensitive to tetracycline antibiotics. Often the medicine is taken for urogenital infections, lesions of the stomach and biliary tract. According to the instructions, the tablets are used to treat the following diseases:

pharyngitis, bronchitis, acute laryngitis and other respiratory tract infections;
traveler's diarrhea;
lesions of the skin and soft tissues;
anthrax, ornithosis, whooping cough;
chlamydia, syphilis;
granuloma and lymphogranuloma.

Directions for use and dosage

Unidox Solutab is often prescribed for severe infections - the instructions for use say that the dosage should be calculated by the attending physician. Typically, in such situations, patients are given 200 mg every day throughout the entire treatment period. For mild infections, the dose of antibiotic on the first day is 200 mg, and then 100 mg. The instructions give the following recommendations on the use of a bactericidal agent for the treatment of infectious diseases:

for cystitis and simple urogenital infections, take 100 mg 2 times a day for 7 days.
For the treatment of gonorrhea, 100 mg 2 times a day is prescribed for 7 days or 600 mg 2 times a day for 1-2 days.
When preventing infections after abortion and other gynecological procedures, 100 mg 1 hour before the intervention and 200 mg after surgery.

The instructions for use state that maximum dose for adults cannot exceed 300 mg/day if the duration of treatment is 5 days. Children are allowed to consume no more than 200 mg per day. If the child's weight is less than 50 kg, then the dose is calculated based on 4 mg/kg. At long-term use According to the instructions, the dosage must be gradually reduced.

special instructions

The drug has an anti-anabolic effect on the entire body, so when it is used, the level of residual nitrogen increases. In patients with renal failure, this leads to an increase in azotemia. Long-term use of the medicine can cause dysbiosis. To prevent dyspeptic symptoms, the tablets are recommended to be taken with food. Uncontrolled use of the drug can cause hypovitaminosis. Patients especially suffer from a deficiency of B vitamins.

During pregnancy

While pregnant, any antibiotics are contraindicated. Tablets can be prescribed during pregnancy if the expected benefit to the mother from their use outweighs the risks to the fetus. During lactation, breastfeeding should be stopped when taking bactericidal capsules. After completion of treatment, the drug will be eliminated from the body after 7-8 days. According to the instructions, breastfeeding can be resumed on days 9-10.

Drug interactions

When taken simultaneously with hormonal contraceptives, the drug reduces the effect of the latter by activating liver metabolism. The instructions say that the drug suppresses intestinal microflora, so it is necessary to adjust the dose of anticoagulants indirect action. Antacids based on calcium, sodium bicarbonate, aluminum, and magnesium reduce the degree of absorption of the drug. The interval between their use should be at least 3 hours.

When combined with penicillin and other bactericidal antibiotics that interfere with cell wall synthesis, doxycycline reduces their effectiveness. The frequency of acyclic bleeding while taking bactericidal capsules and hormonal contraceptives grows based on estrogen. When using a drug with retinol, intracranial pressure increases.

Side effects of tablets

In reviews, patients often complain that dysbiosis develops after taking the medicine. This effect observed when long-term treatment infections with any bactericidal agents. Dysbacteriosis is accompanied by nausea, vomiting, diarrhea, and pseudomembranous colitis. Often patients experience allergic reactions with long-term use of Unidox Solutab. According to the instructions, taking the tablets can cause the following side effects:

dizziness;
hemolytic anemia;
tissue change thyroid gland;
pain in the gastrointestinal tract;
increased intestinal motility;
disruption of normal dental development in children.

Overdose

According to the instructions, when taking large doses of the drug, all side effects increase. It is recommended to immediately rinse the stomach and take sorbents. The doctor may prescribe osmotic laxatives to normalize the patient’s condition. Many patients who leave reviews about treatment do not understand that they have experienced an overdose due to exceeding the recommended concentration of the drug. Continued use of the tablets in such situations leads to widespread liver damage.

Contraindications

The drug is not prescribed for hypersensitivity to tetracycline antibiotics. According to the instructions, people with porphyrin disease should not take the medicine. The use of a bactericidal agent for the treatment of infectious and inflammatory diseases in pregnant women and patients under 8 years of age is prohibited. In case of severe metabolic disorders of the liver and kidneys, Unidox Solutab is not prescribed.

Instructions
(information for specialists)
According to the medical use of the drug
UNIDOX SOLUTAB ®
(UNIDOX SOLUTAB ®)

Registration number: P N013102/01

Tradename: Unidox Solutab ®

INN: Doxycycline

Dosage form: Dispersible tablets

Compound:
Active substance: doxycycline monohydrate 100.0 mg equivalent to doxycycline
Excipients: microcrystalline cellulose, saccharin, hyprolose (low-substituted), hypromellose, colloidal silicon dioxide (anhydrous), magnesium stearate, lactose monohydrate

Description:
Round, biconvex tablets from light yellow to gray-yellow in color with “173” (tablet code) engraved on one side and a scored line on the other.

Pharmacotherapeutic group: Antibiotic - tetracycline

ATX code:

pharmachologic effect:
Pharmacodynamics
Broad-spectrum antibiotic from the tetracycline group. It acts bacteriostatically, suppresses protein synthesis in the microbial cell by interacting with the 30S ribosomal subunit. Active against many gram-positive and gram-negative microorganisms: Streptococcus spp., Treponema spp., Staphylococcus spp., Klebsiella spp., Enterobacter spp. (including E. aerugenes), Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Chlamydia spp., Mycoplasma spp., Ureaplasma urealyticum, Listeria monocytogenes, Rickettsia spp., Typhus exanthematicus, Escherichia coli, Shigella spp., Campylobacter fetus, Vibrio cholerae, Yersinia spp. (including Yersinia pestis), Brucella spp., Francisella tularensis, Bacillus anthracis, Bartonella bacilliformis, Pasteurella multocida, Borrelia recurrentis, Clostridium spp. (except Clostridium difficile), Actinomyces spp., Fusobacterium fusiforme, Calymmatobacterium granulomatosis, Propionibacterium acnes, some protozoa (Entamoeba spp., Plasmodium falciparum).
Typically does not affect Acinetobacter spp., Proteus spp., Pseudomonas spp., Serratia spp., Providencia spp., Enterococcus spp.
The possibility of acquired resistance to doxycycline in a number of pathogens should be taken into account, which is often cross-resistance within the group (i.e., strains resistant to doxycycline will simultaneously be resistant to the entire group of tetracyclines).

Pharmacokinetics
Suction
Absorption is fast and high (about 100%). Food intake has little effect on the absorption of the drug.
The maximum level of doxycycline in the blood plasma (2.6-3 mcg/ml) is achieved 2 hours after taking 200 mg; after 24 hours, the concentration of the active substance in the blood plasma decreases to 1.5 mcg/ml.
After taking 200 mg on the first day of treatment and 100 mg per day on subsequent days, the plasma concentration of doxycycline is 1.5-3 mcg/ml.

Distribution
Doxycycline binds reversibly to plasma proteins (80-90%), penetrates well into organs and tissues, poorly into the cerebrospinal fluid (10-20% of the level in the blood plasma), however, the concentration of doxycycline in the cerebrospinal fluid increases with inflammation of the spinal membrane.
Volume of distribution - 1.58 l/kg. 30–45 minutes after oral administration, doxycycline is found in therapeutic concentrations in the liver, kidneys, lungs, spleen, bones, teeth, prostate gland, eye tissue, pleural and ascitic fluids, bile, synovial exudate, exudate of the maxillary and frontal sinuses, in the fluid of the gingival sulci.
With normal liver function, the level of the drug in bile is 5-10 times higher than in plasma.
In saliva, 5-27% of the concentration of doxycycline in blood plasma is determined.
Doxycycline crosses the placental barrier and is secreted in small quantities into breast milk.
Accumulates in dentin and bone tissue.

Metabolism
A small portion of doxycycline is metabolized.

Removal
The half-life after a single oral dose is 16-18 hours, after repeated doses it is 22-23 hours.
Approximately 40% of the drug taken is excreted by the kidneys and 20 - 40% is excreted through the intestines in the form of inactive forms (chelates).

Pharmacokinetics in special clinical situations
The half-life of the drug in patients with impaired renal function does not change, because its excretion through the intestines increases.
Hemodialysis and peritoneal dialysis do not affect the concentration of doxycycline in blood plasma.

Indications for use
Infectious and inflammatory diseases caused by sensitive
to the drug with microorganisms:

respiratory tract infections, including pharyngitis, acute bronchitis, exacerbation of chronic obstructive pulmonary disease, tracheitis, bronchopneumonia, lobar pneumonia, community-acquired pneumonia, lung abscess, pleural empyema;
infections of the ENT organs, including otitis media, sinusitis, tonsillitis;
infections of the genitourinary system: cystitis, pyelonephritis, bacterial prostatitis, urethritis, urethrocystitis, urogenital mycoplasmosis, acute orchiepididymitis; endometritis, endocervicitis and salpingoophioritis as part of a combined therapy; including sexually transmitted infections: urogenital chlamydia, syphilis in patients with penicillin intolerance, uncomplicated gonorrhea (as an alternative therapy), granuloma inguinale, lymphogranuloma venereum;
infections of the gastrointestinal tract and biliary tract (cholera, yersiniosis, cholecystitis, cholangitis, gastroenterocolitis, bacillary and amoebic dysentery, traveler's diarrhea);
skin and soft tissue infections (including wound infections after an animal bite), severe acne (in the composition combination therapy);
other diseases: yaws, legionellosis, chlamydia various localizations(including prostatitis and proctitis), rickettsiosis, Q fever, Rocky Mountain spotted fever, typhus (including typhus, tick-borne relapsing), Lyme disease (stage I - erythema migrans), tularemia, plague, actinomycosis , malaria; infectious eye diseases, as part of combination therapy - trachoma; leptospirosis, psittacosis, psittacosis, anthrax (incl. pulmonary form), bartonellosis, granulocytic ehrlichiosis; whooping cough, brucellosis, osteomyelitis; sepsis, subacute septic endocarditis, peritonitis;
prevention of postoperative purulent complications; malaria caused Plasmodium falciparum, during short-term travel (less than 4 months) to territories where strains resistant to chloroquine and/or pyrimethamine-sulfadoxine are common.

Contraindications

Directions for use and doses
Usually the duration of treatment is 5-10 days. The tablets are dissolved in a small amount of water (about 20 ml) to obtain a suspension; they can also be swallowed whole, divided into pieces or chewed with water. Preferably taken with food.

Adults and children over 8 years old weighing more than 50 kg Prescribe 200 mg in 1-2 doses on the first day of treatment, then 100 mg daily. In cases of severe infections, Unidox is prescribed at a dose of 200 mg daily throughout treatment.
Children 8-12 years old weighing less than 50 kg the average daily dose is 4 mg/kg on the first day, then 2 mg/kg per day (in 1-2 doses). In cases of severe infections, Unidox is prescribed at a dose of 4 mg/kg daily throughout treatment.

Features of dosing for certain diseases
For infection caused by S.pyogenes, Unidox is taken for at least 10 days.
For uncomplicated gonorrhea (excluding anorectal infections in men):
Adults are prescribed 100 mg twice a day until complete cure (on average within 7 days), or 600 mg is prescribed for one day - 300 mg in 2 doses (the second dose 1 hour after the first).

For primary syphilis, 100 mg is prescribed twice a day for 14 days, for secondary syphilis - 100 mg twice a day for 28 days.

For uncomplicated urogenital infections caused by Chlamydia trachomatis, cervicitis, non-gonococcal urethritis caused by Ureaplasma urealiticum, 100 mg is prescribed 2 times a day for 7 days.

For acne, 100 mg/day is prescribed, the course of treatment is 6-12 weeks.

Malaria (prevention): 100 mg 1 time per day 1-2 days before the trip, then daily during the trip and for 4 weeks after return; for children over 8 years old, 2 mg/kg 1 time per day.

Traveler's diarrhea (prevention) - 200 mg on the first day of the trip (in 1 dose or 100 mg 2 times a day), then 100 mg 1 time per day throughout your stay in the region (no more than 3 weeks).

Treatment of leptospirosis - 100 mg orally 2 times a day for 7 days; prevention of leptospirosis - 200 mg once a week during stay in a disadvantaged area and 200 mg at the end of the trip.

To prevent infections during medical abortion, 100 mg is prescribed 1 hour before and 200 mg after the intervention.

Maximum daily doses for adults are up to 300 mg/day or up to 600 mg/day for 5 days for severe gonococcal infections. For children over 8 years old weighing more than 50 kg - up to 200 mg, for children 8-12 years old weighing less than 50 kg - 4 mg/kg daily throughout treatment.

In the presence of renal (creatinine clearance less than 60 ml/min) and/or liver failure, a decrease in daily dose doxycycline, since it gradually accumulates in the body (risk of hepatotoxicity).

Side effects
From the gastrointestinal tract:
anorexia, nausea, vomiting, dysphagia, diarrhea, enterocolitis, pseudomembranous colitis.

Dermatological and allergic reactions:
urticaria, photosensitivity, angioedema, anaphylactic reactions, exacerbation of systemic lupus erythematosus, maculopapular and erythematous rash, pericarditis, exfoliative dermatitis.

From the liver:
liver damage (with long-term use of the drug or in patients with renal or liver failure).

From the kidneys: an increase in residual urea nitrogen due to the antianabolic effect of the drug.

From the hematopoietic system:
hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia, decreased prothrombin activity.

From the nervous system:
benign increase in intracranial pressure (anorexia, vomiting, headache, swelling optic nerve), vestibular disorders(dizziness or unsteadiness).

From the thyroid gland:
In patients receiving long-term doxycycline, reversible dark brown discoloration of the thyroid tissue is possible.

For teeth and bones:
doxycycline slows down osteogenesis, disrupts the normal development of teeth in children (the color of teeth irreversibly changes, enamel hypoplasia develops).

Other:
candidiasis (stomatitis, glossitis, proctitis, vaginitis) as a manifestation of superinfection.

Overdose
Symptoms:
Gain adverse reactions caused by liver damage - vomiting, fever, jaundice, azotemia, increased transaminase levels, increased prothrombin time.
Treatment:
Immediately after taking large doses, gastric lavage is recommended, drinking plenty of fluids, if necessary, induce vomiting. Accept Activated carbon and osmotic laxatives. Hemodialysis and peritoneal dialysis are not recommended due to low efficiency.

Drug interactions
Antacids containing aluminum, magnesium, calcium, iron preparations, sodium bicarbonate, magnesium-containing laxatives reduce the absorption of doxycycline, so their use should be separated by an interval of 3 hours.
Due to the suppression of intestinal microflora by doxycycline, the prothrombin index decreases, which requires dose adjustment of indirect anticoagulants.
When doxycycline is combined with bactericidal antibiotics that interfere with cell wall synthesis (penicillins, cephalosporins), the effectiveness of the latter is reduced.
Doxycycline reduces the reliability of contraception and increases the frequency of acyclic bleeding when taking estrogen-containing hormonal contraceptives.
Ethanol, barbiturates, rifampicin, carbamazepine, phenytoin and other stimulants of microsomal oxidation, accelerating the metabolism of doxycycline, reduce its concentration in the blood plasma.
The simultaneous use of doxycycline and retinol increases intracranial pressure.

special instructions
There is a possibility of cross-resistance and hypersensitivity with other tetracycline drugs.
Tetracyclines may increase prothrombin time; the use of tetracyclines in patients with coagulopathies should be carefully monitored.
The anti-anabolic effect of tetracyclines can lead to an increase in the level of residual urea nitrogen in the blood. Typically this does not have significant for patients with normal function kidney However, in patients with renal failure, an increase in azotemia may occur. The use of tetracyclines in patients with impaired renal function requires medical supervision.
With long-term use of the drug, periodic monitoring of laboratory blood parameters, liver and kidney function is required.
Due to the possible development of photodermatitis, it is necessary to limit insolation during treatment and for 4-5 days after it.
Long-term use of the drug can cause dysbacteriosis and, as a result, the development of hypovitaminosis (especially B vitamins).
To prevent dyspeptic symptoms, it is recommended to take the drug with meals.

Features of the influence on the ability to drive a car and operate machinery have not been studied.

Release form
Dispersible tablets 100 mg; 10 tablets in a PVC/aluminum foil blister. 1 blister along with instructions for use in a cardboard box.

Storage conditions
At temperatures from 15 to 25 ºС.
Keep out of the reach of children!

Best before date
5 years.
Do not use after the expiration date stated on the package.

Conditions for dispensing from pharmacies
On prescription.

Produced:

Elisabethof 19, Leiderdorp

Packaged and/or packaged:
Astellas Pharma Europe B.V., Netherlands
or ZAO ORTAT, Russia

Consumer complaints should be sent to:
Moscow representative office of Astellas Pharma Europe B.V., the Netherlands:
109147 Moscow, Marksistskaya st. 16
"Mosalarco Plaza-1" business center, floor 3