*registered by the Ministry of Health of the Russian Federation (according to grls.rosminzdrav.ru)

Registration number

LSR-001808/08

Tradename

Octolipen ®

International nonproprietary or generic name:

Thioctic acid

Dosage form:

concentrate for the preparation of solution for infusion

Composition per ampoule:

Active substance: thioctic acid (a-lipoic acid) - 300 mg
Excipients: ethylenediamine -87.4 mg; disodium edetate (disodium salt of ethylenediaminetetraacetic acid) – 1 mg; water for injections up to 10ml

Description: transparent greenish-yellow liquid

Pharmacotherapeutic group:

metabolic agent

ATX code: A16AX01

Pharmacological properties

Thioctic acid ( alpha lipoic acid) is an endogenous antioxidant (binds free radicals), formed in the body during the oxidative decarboxylation of alpha-keto acids. As a coenzyme of mitochondrial multienzyme complexes, it participates in oxidative decarboxylation pyruvic acid and alpha-keto acids. Helps reduce blood glucose concentrations and increase glycogen content in the liver, as well as overcome insulin resistance. By the nature of its biochemical action it is close to B vitamins. Participates in the regulation of lipid and carbohydrate metabolism, stimulates cholesterol metabolism, and improves liver function.
It has hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic effects. Improves neuronal trophism and axonal conduction, reduces the manifestations of diabetic and alcoholic polyneuropathy.

Pharmacokinetics

At intravenous administration the maximum concentration is 25-38 μg/ml, the area under the concentration-time curve is about 5 μg h/ml. Volume of distribution is about 450 ml/kg.
Metabolized in the liver by side chain oxidation and conjugation. Thioctic acid and its metabolites are excreted by the kidneys (80-90%). The half-life is 20-50 minutes. Total plasma clearance is 10-15 ml/min.

Indications for use

• diabetic polyneuropathy;
• alcoholic polyneuropathy.

Contraindications

• hypersensitivity to the components of the drug;
• childhood up to 18 years of age (efficacy and safety of use have not been established);
• pregnancy and breastfeeding period.

Directions for use and doses

For cooking infusion solution 1-2 ampoules (300-600 mg) of the drug are diluted in 50-250 ml of 0.9% sodium chloride solution. The prepared solution is administered intravenously. Apply 300-600 mg 1 time per day for 2-4 weeks. Subsequently, they switch to oral therapy.
The drug is photosensitivity, so the ampoules should be removed from the packaging only immediately before use. It is advisable to protect the bottle with the solution from light during the infusion (light-protective bags or aluminum foil can be used). The prepared solution must be stored in a place protected from light and used within a maximum of 6 hours after preparation.

Side effects

Possible allergic reactions: urticaria, systemic allergic reactions (up to the development of anaphylactic shock).
Symptoms of hypoglycemia may develop (due to improved glucose absorption).
With intravenous administration, convulsions and diplopia are very rarely possible; pinpoint hemorrhages in the mucous membranes, skin; thrombocytopathy; hemorrhagic rash (purpura), thrombophlebitis.
At rapid introduction possible increase in intracranial pressure (a feeling of heaviness in the head); difficulty breathing.
The listed side effects go away on their own.

Overdose

Symptoms: headache, nausea, vomiting.
Treatment: symptomatic. There is no specific antidote.

Interaction with other drugs

Thioctic acid (in the form of a solution for infusion) leads to a decrease in the effect of cisplatin.
When used simultaneously with insulin and/or oral hypoglycemic agents, an increase in the hypoglycemic effect is observed.
Thioctic acid forms poorly soluble complex compounds with sugar molecules. The prepared solution is incompatible with glucose solution, levulose, Ringer's solution, as well as with compounds (including their solutions) that react with disulfide and SH groups.

special instructions

In patients diabetes mellitus, especially at the beginning of treatment, frequent monitoring of blood glucose concentrations is necessary. In some cases, a reduction in the dose of hypoglycemic agents is required.
During treatment, it is necessary to strictly abstain from drinking alcohol, since exposure to alcohol weakens the therapeutic effect of thioctic acid.
Ethanol reduces the therapeutic effectiveness of thioctic acid.

Release form

Concentrate for the preparation of solution for infusion 30 mg/ml.
10 ml in ampoules made of light-protective glass.
5 ampoules per blister pack without foil.
1 or 2 contour packages with instructions for use in a cardboard pack.

Storage conditions

In a place protected from light at a temperature not exceeding 25°C.
Keep out of the reach of children.

Best before date

2 years. Do not use after expiration date.

Conditions for dispensing from pharmacies

On prescription.

Manufacturer and organization accepting consumer complaints

PJSC "Pharmstandard-UfaVITA", 450077,
Russia, Ufa, st. Khudaiberdi-na, 28,
www.pharmstd.ru

The domestic drug octolipene (active ingredient - thioctic acid) is a vitamin-like drug that has an antioxidant effect and controls the metabolism of carbohydrates and fats. It occupies a rather narrow pharmacological “niche”: according to the instructions for use, it has only two indications for use - diabetic and alcoholic polyneuropathy, in other words, lesions peripheral nerves due to alcohol abuse or a history of diabetes. The word “antioxidant” is on everyone’s lips, but not everyone has a well-formed understanding of it. To eliminate this relative information vacuum, it makes sense to briefly explain what these substances are. So, antioxidants are oxidation inhibitors that prevent the effects on the body free radicals, thereby slowing down the process of cellular aging. So, thioctic acid (read: octolipene) is an endogenous (formed in the body itself) antioxidant, the progenitor of which is the process of oxidative decarboxylation of alpha-keto acids. As a coenzyme of multienzyme complexes of mitochondria (“energy stations” of the cell), it takes part in the oxidative decarboxylation of a-ketopropionic (pyruvic) acid and alpha-keto acids. Reduces plasma glucose levels and increases the concentration of glycogen in the liver. Creates conditions for overcoming insulin resistance. In its biochemical “habits,” octolipene is very close to B vitamins.

The drug is one of the regulators of carbohydrate and lipid metabolism, stimulates cholesterol metabolism, and improves the functional characteristics of the liver. It has hepatoprotective, hypocholesterolemic, hypolipidemic and hypoglycemic effects. Activates the processes of cellular nutrition of neurons, improves conductivity in axons.

Octolipen is available in three dosage forms ah: capsules, tablets and concentrate for the preparation of solution for infusion. Latest form release of the drug is used mainly in hospital settings, while the first two can easily settle in home medicine cabinet. Oral forms of octolipene should be taken on an empty stomach, half an hour before meals, with a sufficient amount of liquid. In this case, the tablets should not be chewed (capsules, of course, are out of the question in this context). The recommended dose of the drug is 600 mg, which is equivalent to one tablet or two capsules. The frequency of administration is 1 time per day. The duration of the medication course is determined by the doctor. It is possible to combine different dosage forms of octolipene: first, the drug is administered parenterally for 2-4 weeks, after which it is switched to one of the oral forms. The maximum duration of the course is 3 months, but in some cases, according to indications, it is allowed to go beyond this time period. You should be aware that taking octolipene is incompatible with drinking alcohol. It is also not recommended to consume dairy products.

Pharmacology

Thioctic acid (α-lipoic acid) is an endogenous antioxidant (binds free radicals), formed in the body during the oxidative decarboxylation of α-keto acids. As a coenzyme of mitochondrial multienzyme complexes, it participates in the oxidative decarboxylation of pyruvic acid and α-keto acids. Helps reduce blood glucose and increase glycogen content in the liver, as well as overcome insulin resistance. By the nature of its biochemical action, thioctic acid is close to B vitamins. It participates in the regulation of lipid and carbohydrate metabolism, stimulates cholesterol metabolism, and improves liver function.

It has hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic effects. Improves neuronal trophism and axonal conduction, reduces the manifestations of diabetic and alcoholic polyneuropathy.

Pharmacokinetics

Suction and distribution

When taken orally, it is quickly and completely absorbed; taking it with food reduces absorption. Bioavailability - 30-60% due to the “first pass” effect through the liver. Time to reach Cmax - 25-60 minutes.

Metabolism and excretion

Metabolized in the liver by side chain oxidation and conjugation. Thioctic acid and its metabolites are excreted by the kidneys (80-90%). T 1/2 - 20-50 min. Total plasma clearance is 10-15 ml/min.

Release form

Hard gelatin capsules, size No. 0, opaque, yellow; the contents of the capsules are light yellow or yellow powder; White inclusions are allowed.

Excipients: calcium hydrophosphate (dibasic calcium phosphate) - 23.7 mg, pregelatinized starch - 21 mg, colloidal silicon dioxide (Aerosil) - 1.8 mg, magnesium stearate - 3.5 mg, hard gelatin capsules - 97 mg (titanium dioxide (E171) - 2.667 %, quinoline yellow (E104) - 1.839%, sunset yellow dye (E110) - 0.0088%, medical gelatin - up to 100%).

10 pieces. - contour cellular packaging (3) - cardboard packs.
10 pieces. - contour cellular packaging (6) - cardboard packs.

Dosage

The drug is taken orally, on an empty stomach, 30 minutes before the first meal, without chewing and with a sufficient amount of water.

The duration of the course of treatment is determined by the doctor.

Overdose

Symptoms: headache, nausea, vomiting.

Treatment: carrying out symptomatic therapy. There is no specific antidote.

Interaction

When used simultaneously with insulin and oral hypoglycemic drugs, an increase in the hypoglycemic effect is observed.

After taking thioctic acid in the morning, taking iron and magnesium supplements, as well as consuming dairy products (due to the calcium they contain), is not recommended; you should reschedule their intake to a later time (after lunch or in the evening).

Ethanol reduces the therapeutic effectiveness of thioctic acid.

Side effects

Allergic reactions: possible - urticaria, systemic allergic reactions (up to the development of anaphylactic shock).

Metabolism: symptoms of hypoglycemia may develop (due to improved glucose absorption).

Octolipen - drug, found in tablets and capsules, as well as ampoules.

Octolipen, instructions for use of which are contained in the package, contains thioctic acid, another name - lipoic acid - belongs to the group of endogenous antioxidants, neutralizes free radicals by interacting with them chemical reaction. Thus, it reduces oxidative stress and improves metabolic processes, speeds up the metabolism of fats and carbohydrates.

Octolipen has a hypoglycemic effect and accelerates the formation of glycogen in the liver, correcting the metabolic response to insulin. Due to this property, Octolipen is recommended for type 2 diabetes mellitus, and can also be prescribed for other forms of diabetes among medications complex therapy.

For type 2 diabetes mellitus, the medication not only regulates metabolic processes, but also promotes weight loss. The drug reduces the severity dystrophic symptoms from the outside nervous system, has a pronounced anti-sclerotic, hepatotropic, hypoglycemic and hypolipidemic effect.

One of serious complications Diabetes mellitus is a disorder of the autonomic nervous system. Due to its property of having a positive effect on trophism nerve cells, Octolipen helps reduce the risk of this complication and reduce visible manifestations. The drug belongs to the class of coenzymes and is similar in nature to B vitamins.

Compound

Octolipene contains thioctic acid as an active ingredient ( chemical name- α-lipoic acid). In addition to this, there are a number excipients. You need to understand that there are two groups of auxiliary components: some are part of the tablet (capsule) itself, and others are part of the dosage form shell.

The auxiliary components in Octolipen are most often used (the composition and shells of oral agents are indicated):

• All capsule and tablet forms contain fillers - gelatin for medical purposes (for capsules) and calcium hydrogen phosphate dihydrate, magnesium stearate (tablets). The dyes are quinoline yellow and sunset yellow. Colloidal silicon dioxide is necessary to “glue” the entire mass, and titanium dioxide is necessary to give “whiteness” to the tablet mass, hyprolase, croscarmellose.
• The solution for infusion also contains ethylenediamine (buffer solution), disodium edetate (preservative), and water for injection.

Release form of the drug

Octolipen, the instructions for use of which describe the main properties of the medicine, can be found in the form of tablets and capsules for oral administration, for preparation injection solution ampoules are produced. Octolipen tablets have a regular round shape, coated, color from light yellow to yellow. Available in 10 pieces in blister packs, in a box of 3, 6 or 10 blisters.

Octolipen capsules are light yellow; the contents may contain minor white inclusions. Available in 10 pieces per blister, 3, 6 or 10 blisters per cardboard box. Octolipen ampoules are a concentrate for diluting an injection solution. Represents clear liquid, yellow-green color. Sold in tinted glass ampoules of 10 ml. There are 5 of them in a blister, packed in a box of 1 or 2 blisters.

Indications and contraindications

Together with others medications Octolipen is prescribed for:

• Diabetic polyneuropathy.
• Neuralgia of various types.
• Alcoholic polyneuropathy.
• Liver lesions of infectious and non-infectious etiology.
• Obesity caused by errors in lipid metabolism.
• Poisoning.
• In order to reduce blood cholesterol levels.

Contraindications include children under 18 years of age, pregnancy, breast-feeding and individual intolerance to individual components of the drug.

It should be noted that Octolipen cannot be taken simultaneously with glucose, and when taken along with the minerals Fe, Mg and Ca, they must be diluted over time.

Side effects

It is important to know that Octolipen does not have a specific antidote, therefore, for symptoms of poisoning, only symptomatic treatment is carried out.

TO side effects should include:

• allergic reactions (urticaria, swelling, maybe anaphylactic shock);
• petechiae, thrombophlebitis;
• rapid heartbeat, can rise intracranial pressure;
• dizziness, weakness, sweating - associated with low blood sugar levels.

If the daily dose is exceeded, the following symptoms may be observed: signs of hypoglycemia, dyspeptic symptoms, weakness, confusion. A specific antidote is unknown, so they are used general measures, as with any poisoning - drinking plenty of fluids, provoking vomiting, taking adsorbents and symptomatic treatment.

Patients suffering from diabetes mellitus should remember that taking lipolic acid leads to better absorption glucose, and this, in turn, can lead to a significant decrease in its level in the lymph and peripheral blood. To prevent hypoglycemic coma, it is necessary to monitor your sugar levels and discuss the dosage of insulin and other antidiabetic drugs with your doctor. Although active substance The drug is a vitamin-like component; it is not recommended to take it without a doctor’s prescription.

If you experience unusual sensations or develop complications while taking the drug, be sure to consult a specialist.

Octolipen: instructions for use, ampoules and tablets

Each drug is unique in that it contains an ingredient that acts to improve some processes in the body, or, conversely, slow down the reaction rate. Octolipen tablets, instructions for use of which are described below, are no exception.

Each tablet contains 0.6 grams active component(lipoic acid) and additional substances- dyes, stabilizers. The capsule contains 0.3 grams of active ingredient.

For diabetic polyneuropathy, it is recommended to take oral tablet and capsule forms of the drug once a day, 20-40 minutes before meals. It is better to do this in the first half of the day, on an empty stomach. A single dose is 0.6 grams - respectively, 1 tablet or 2 capsules per dose.

Do not open the capsules; take the medicine with plenty of water. The duration of the appointment is determined by the doctor.

Usually they take Octolipen tablets, the instructions for use included in the package are for 3 months, but if necessary, the use of the drug can be continued. To prepare an injection solution, another type of medicine, Octolipen, is used. Instructions for use: ampoules from concentrates in the amount of 1-2 pieces are diluted, respectively, in 50-250 milliliters of physiological solution.

It is recommended to protect the finished mixture from light and store for up to 6 hours. Octolipen solution is administered intravenously, slowly, once a day, 300-600 milliliters. Treatment time is 2-4 weeks. For best result After completing the parenteral course of taking the drug, the doctor prescribes an oral course for 2-3 months. To better understand how thioctic acid works, you need to know whether it is found in the body initially or comes from water/food. Scientists have found that during the decarboxylation of α-keto acids, this acid is formed in the body.

Thioctic acid acts as a free radical scavenging agent, so it is most often used as an endogenous antioxidant. One of its important actions is the ability to reduce glucose concentrations and at the same time increase tissue resistance to insulin. B vitamins act similarly to thioctic acid. These substances are coenzymes in the cascade of reactions for the oxidation of pyruvic acid.

Medicine Octolipen and its analogues

The drug Octolipen is exactly the same as others medical supplies must be taken strictly according to instructions. In case of an overdose, processes may begin in the body that will cause discomfort and pain.

So, if the dose is violated, the following may begin:

• headache;
• nausea;
• vomit;
• mental disorders;
• coma;
• malfunctions bone marrow;
• acute necrosis of skeletal muscles;
• convulsions general;
• destruction of red blood cells and bleeding;
• disruption of the activity of many vital organs.

If a patient experiences these symptoms, it is necessary to immediately consult a doctor. During the examination, the doctor will establish the most accurate picture of the result of the overdose and prescribe treatment. In general cases, the measures are practically the same as in the case of drug poisoning.

First, you need to get rid of the drug in the body, so they take measures such as:

• gastric lavage;
• reception activated carbon;
• inducing vomiting.

When severe poisoning, which led to spasms and convulsions, the specialist prescribes intensive therapy. It is important to know that there is no medicine in medicine that could fight intoxication. If there are filtration methods that are aimed at removing poison from the body, then these methods are ineffective.

Whenever primary signs poisoning requires urgent hospitalization, since the effect of the drug is very strong. If you ignore these symptoms, the consequences can be unpredictable.

Interaction

The drug Octolipen has a very strong effect on the body's production of insulin, so it is necessary to carefully monitor the dosage. Using this drug with antidiabetic drugs may cause your blood glucose levels to increase. In this case, it is necessary to strictly monitor the dosage and consult a specialist who will reduce the dose. It should be noted that the dosage cannot be changed independently, as this may lead to the ineffectiveness of the drug.

When taking this medication, you need to know that after Octolipen you should not consume milk products or take products that contain calcium, magnesium and iron. If the patient is prescribed Octolipen and other drugs with these minerals, then it is better to take one drug in the morning, the other in the evening. If you take the medicine along with cisplatin, the effectiveness will decrease.

A drug containing thioctic acid together with glucose becomes a sparingly soluble compound. So, it is worth refraining from using this acid with Ringer's solution, as well as solutions that lead to a reaction with disulfide groups. Taking into account these details and nuances, you can achieve good results during treatment. The patient should not forget that during the course of treatment with this drug it is prohibited to take alcoholic beverages. This is due to the fact that ethanol suppresses the effect of the drug.

Analogues

The medicine Octolipen has analogues that are offered in pharmacies and such analogues include:

• Thiogamma.
• Neurolipon.
• Espa lipon.
• Alpha lipoic acid.
• Lipothioxone.
• Thioctic acid.
• Thiolepta.
• Lipamide.
• Thiolipon.
• Thioctacid.

A drug with an antioxidant effect that regulates carbohydrate and lipid metabolism

Active substance

Thioctic acid (α-lipoic acid)

Release form, composition and packaging

Film-coated tablets from light yellow to yellow, oval, biconvex, with a notch on one side; on the fracture from light yellow to yellow.

Excipients: low-substituted hyprolose (low-substituted hydroxypropylcellulose) - 108.88 mg, hyprolose (hydroxypropylcellulose) - 28.04 mg, croscarmellose (croscarmellose sodium) - 24.03 mg, colloidal silicon dioxide - 20.025 mg, magnesium stearate - 20.025 mg.

Shell composition: Opadry yellow (OPADRY 03F220017 Yellow) - 28 mg (hypromellose (hydroxypropyl methylcellulose) - 15.8 mg, macrogol 6000 (polyethylene glycol 6000) - 4.701 mg, titanium dioxide - 5.27 mg, talc - 2.019 mg, quinoline yellow aluminum varnish (E104) - 0.1 62 mg , iron oxide yellow dye (E172) - 0.048 mg).

10 pieces. - contour cell packaging (3) - cardboard packs.
10 pieces. - contour cell packaging (6) - cardboard packs.
10 pieces. - contour cell packaging (10) - cardboard packs.

pharmachologic effect

Enhances the effect of insulin and oral hypoglycemic drugs medicines(dosage adjustment is necessary, as well as regular monitoring of blood glucose levels to avoid hypoglycemia).

Simultaneous use of the drug Octolipen and preparations of iron, magnesium and calcium is not recommended (due to the formation of a complex with metals). The interval between doses should be at least 2 hours.

Ethanol and its metabolites weaken the therapeutic activity of thioctic acid.

special instructions

During treatment (especially during initial stage) regular monitoring of blood glucose levels is necessary in patients with diabetes mellitus. In some cases, it may be necessary to reduce the dose of insulin or oral hypoglycemic drug to avoid the development of hypoglycemia.

Patients taking Octolipen should avoid drinking alcohol.

Concomitant food intake may interfere with the absorption of the drug.

When taking Octolipen, consumption of dairy products is not recommended (due to their calcium content). The interval between doses should be at least 2 hours.

Impact on the ability to drive vehicles and operate machinery

Impact on ability to manage vehicles and the mechanisms have not been specifically studied. Necessary
use caution when driving or engaging in potentially dangerous activities dangerous species activities that require increased concentration and speed of psychomotor reactions.

Pregnancy and lactation

The use of the drug during pregnancy is contraindicated due to the lack of sufficient clinical experience use of thioctic acid in pregnant women. Reproductive toxicity studies did not reveal any risks to fertility, effects on fetal development or any embryotoxic properties of the drug.

The use of Octolipen during lactation is contraindicated due to the lack of data on the penetration of thioctic acid into breast milk.

Use in childhood

The use of the drug in children and adolescents under 18 years of age is contraindicated (efficacy and safety have not been established).

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life - 2 years.

"Octolipen" is a drug with an antioxidant effect that regulates lipid and carbohydrate metabolism.

The drug is available in three forms: tablets, capsules and ampoules with concentrate.

Main active substance"Octolipene" is thioctic acid. Let's consider the composition of each dosage form.

Capsules

Capsules contain 300 mg of active ingredient.

The following auxiliary components were used:

• Gelatin.
• Silicon dioxide colloidal.
• Quinoline yellow.
• Sunset dye.
• Starch.
• Calcium hydrophosphate.
• Magnesium stearate.

The dosage form is hard capsules yellow color. "Octolipen" in this form is produced in blister packs of 10 pieces on one blister. Secondary packaging can contain 30 and 60 capsules.

Pills

One tablet contains 600 mg of active ingredient.

• Hyprolose.
• Hyprolose is low-substituted.
• Colloidal silicon dioxide.
• Croscarmellose sodium.
• Macrogol 6000.
• Talc.
• Titanium dioxide
• Iron oxide is yellow.
• Aluminum varnish based on quinoline yellow.

The dosage form is pale yellow, biconvex tablets. There is a mark on one side of the tablet. The drug is available in blister packs of 30, 60 and 100 tablets.

Concentrate for droppers

One ampoule contains 30 mg of active ingredient (calculation is per 1 ml).

The following additional components were used:

• Disodium edetate.
• Ethylenediamine.
• Water for injections.

The concentrate for preparing a solution for infusion has a greenish-yellow color and is available in 10 ml dark glass ampoules. Secondary packaging contains 10 and 20 ampoules.

Pharmacological properties of the drug "Octolipen", pharmacokinetics

Thioctic acid is formed during the oxidative decarboxylation of keto acids and, by its structure, is an endogenous antioxidant. Its main functions include binding free radicals and restoring intracellular glutathione levels. In addition, it improves the trophism of neurons and the conductivity of nerve cells. Thioctic acid, being a coenzyme, is involved in the oxidative decarboxylation of pyruvic acid.

As a result of the influence of the drug, the level of glycogen in the liver increases and glucose in the blood decreases, and insulin resistance is overcome. The nature of the biochemical action of thioctic acid is similar to that of B vitamins. The substance normalizes lipid and carbohydrate metabolism, activates cholesterol metabolism; exhibiting a lipotropic effect, improves liver activity; demonstrates a detoxification effect in cases of intoxication, including poisoning with salts of heavy metals.

At orally"Octolipen" is quickly absorbed into gastrointestinal tract. Simultaneous use Taking the drug with food slows down its absorption, so it must be taken separately. The bioavailability of the drug is 30-60%. The maximum concentration in blood plasma is achieved 25-40 minutes after a single dose.
Thioctic acid is metabolized in the liver. It is excreted primarily by the kidneys in an amount of 80-90% of the initial dose.

Main indications for taking Octolipen

The main indications of the drug "Octolipen" include:

• Polyneuropathy of various origins(diabetic, alcoholic).
• Liver dystrophy (including fatty degeneration).
• Hepatitis in chronic form.
• Alcohol poisoning.
• High cholesterol.
• Liver cirrhosis with metastases.
• Hepatitis A at any stage.
• Poisoning by poisonous species of mushrooms.

Method of taking the drug "Octolipen", dosage regimen

Thioctic acid in oral forms (tablets, capsules) should be taken orally on an empty stomach, before meals. Neither tablets nor capsules should be chewed, divided, or opened. "Octolipen" is taken orally whole and washed down big amount water.
The recommended dose for an adult is 600 mg per day. This amount is equivalent to one tablet or two capsules.
Oral forms of release are not recommended for more than 3 months, but if necessary, the course of treatment can be extended.
As for the concentrate for infusion, before use it must be diluted with isotonic sodium chloride solution (from 50 to 250 ml). The prepared solution is administered intravenously once a day. The average daily dose should not exceed 600 mg. The course of treatment is from 2 to 4 weeks.
It is worth noting that “Octolipen” in ampoules is very sensitive to light, so it is necessary to protect the drug from direct contact sun rays. For these purposes, it is better to use foil or dark bags. The prepared solution is stored for no more than 6 hours from the moment of preparation.

Contraindications for the drug "Octolipen"

The drug "Octolipen" is quite often prescribed by doctors and has a relatively small list of contraindications. These include:

• Children under 18 years of age (due to lack of clinical data).
• Individual intolerance to the components of the drug.
• Pregnancy.
• Breastfeeding period.

Side effects of the drug "Octolipen"

Despite the popularity of the drug among doctors, it is necessary to take into account side effects, which are not so rare. These include:

• Dyspeptic disorders (diarrhea, nausea, vomiting, abdominal pain). Characteristic for oral forms of release.
• Decreased blood glucose levels, hypoglycemia.
• Increased sweating.
• Dizziness.
• Frequent headaches.
• Visual impairment.
• Allergic reactions: urticaria, itching, skin rash, anaphylactic shock.
• Pinpoint hemorrhages in the mucous membranes.
• Hemorrhagic rash, convulsions. Characteristic for intravenous administration.
• Thrombophlebitis.
• Thrombocytopenia.
• Violation taste sensations.
• Labored breathing
• Increased intracranial pressure.

Cases of drug overdose have been recorded. In this case, vomiting, nausea, headache, and decreased sugar levels are observed. If a severe overdose of the drug is suspected, emergency hospitalization and standard measures are required, including gastric lavage and the use of enterosorbents.

special instructions

1. Patients with diabetes mellitus during treatment with Octolipen should monitor their blood glucose levels. In some cases, reducing the dose of insulin or oral antidiabetic agent may be necessary to prevent hypoglycemia.
2. During therapy it is necessary to stop taking alcoholic drinks to avoid weakening therapeutic effect thioctic acid.
3. When using oral forms of Octolipen, it is recommended to refrain from consuming dairy products due to the calcium they contain.
4. An interval of at least 2 hours should be maintained between doses.

Drug interactions

1. The simultaneous use of thioctic acid and cisplatin reduces the effectiveness of the latter.
2. Insulin in complex therapy enhances the effect of thioctic acid. Dose adjustment is necessary in insulin-dependent patients.
3. Solution for infusion "Octolipen" is incompatible with solutions of levulose, glucose, and Ringer's solution.
4. Simultaneous intake of thioctic acid with ethanol weakens the effect of the former.
5. "Octolipen" interacts with drugs containing calcium, magnesium and iron salts, forming complex compounds.

Analogues of the drug "Octolipen"

"Octolipen" has several structural analogues, which completely coincide in composition and pharmacological group. These include:

• "Berlition".
• "Tiogamma".

It is worth remembering that Octolipen and its analogues are prescription drugs and should be prescribed only by the attending physician, to avoid complications and side effects.

Sources:

• https://www.vidal.ru/drugs/octolipen__18164

Tip 2: Octolipen: instructions for use, indications, price

Polyneuropathy is a disease that affects the peripheral parts of the nervous system. The onset of the disease can be caused by diabetes, excessive consumption alcohol. It is very life-threatening, so it is very important to identify it promptly and begin treatment. The disease can be stopped by intensive care. Often, for polyneuropathy, doctors prescribe the metabolic drug Octolipen to patients.

Compound

The main component of Octolipen is thioctic acid, the dosage of which depends on the form of release. Russian pharmaceutical company offers customers the drug in the form of tablets, capsules and concentrate for preparing a solution.

Pharmacokinetics

When taking the medicine, the active substance is quickly and almost completely absorbed into the blood. Maximum concentration reaches within 25-60 minutes. It is broken down by the liver and excreted by the kidneys.

Since food slows down the absorption of the drug, it is better to take it half an hour before a meal.

Indications

Thioctic acid is prescribed by neurologists for polyneuropathy caused by diabetes and alcoholism.

Contraindications

The drug should be completely discontinued during pregnancy. When breastfeeding, Octolipen is also contraindicated. In pediatrics this acid not applicable since the safety of its use has not been established. The drug is incompatible with alcohol.

Mode of application

Tablets and capsules should be taken before meals with a clean water. Daily dose an adult should not exceed 600 mg. The drug is taken once a day for 1-3 months. Possibly more long-term treatment, but only under the supervision of a doctor.

For cooking intravenous solution the contents of 1-2 ampoules are combined with 50-250 ml of sodium chloride. The medicine is administered slowly. The dosage is determined by the doctor, but cannot be more than 600 mg. Injection therapy lasts 2-4 weeks, then the patient can be transferred to oral administration thioctic acid. The prepared solution must be used within 6 hours.

Side effects

Unpleasant consequences while taking the drug occur quite rarely. Some patients complain of nausea, heartburn, diarrhea and abdominal pain. On the part of the nervous system, a change in taste sensations may be noted. Changes in blood glucose levels are extremely rare, so it is important for diabetics to monitor their blood data during treatment. Symptoms of hypoglycemia may occur. If you are intolerant to thioctic acid, it is possible skin rashes and itching. When unpleasant effects You should contact your doctor to decide whether to continue taking the medicine.

Price and analogues

The cost of "Octolipen" with the active ingredient with a dosage of 300 mg is 350 rubles for 30 capsules. The same number of tablets, but with 600 mg of thioctic acid, cost 700 rubles. 10 ampoules of concentrate will cost the buyer 450 rubles.

You can buy cheaper analogues at the pharmacy, for example, tablets " Lipoic acid", solution "Tiogamma". When replacing a drug, carefully read the instructions from others medicines, as they may have other contraindications.