What pills do you take after unprotected intercourse? HCG-type drugs that help you get pregnant. The disadvantages of the intrauterine device include

In the recent past, when effective protection there were few, women often used the calendar method of calculating the safe period menstrual cycle, and also used the interrupted act method. Now that medicine has made great progress, it makes no sense to use the methods of protection described above, so everything larger number couples tend to use officially recognized methods of contraception. But if they were not used in time, then birth control pills after sexual intercourse will save the situation. Which remedy is the most effective?

When and who might need them?

The correct answer to the question of when contraceptives may be needed is after unprotected sexual intercourse, when there is a risk of pregnancy. This is possible in the following cases:

1. No protection was used.
2. The rape occurred and the woman was not taking effective contraception at the time.
3. The usual method of contraception did not work.

The last point needs to be deciphered in order to clarify when this is possible. Most common cause there is a missed dose OK ( oral contraceptive), as well as untimely injection of a hormone used for parenteral contraception. Sometimes after sex a woman notices that the contraceptive ring has moved or was installed incorrectly cervical cap, along with leucorrhoea and ejaculate, suppositories or tablets with a spermicidal effect and used for contraception came out of the vagina.

Any suspicion of incorrect operation using the usual contraceptive is a reason to contact a gynecologist for advice on further contraceptive options.

Today in every way medicinal drug For emergency contraception After unprotected sex, hormonal components are used.

What drugs for postcoital pregnancy prevention are known? Now official medicine There are two recognized methods of emergency contraception after unprotected sex. They are the use of copper-containing intrauterine devices (spirals) during the first 5 days and the use of tableted postcoital medications. To use the first method, you must visit an obstetrician-gynecologist first for a consultation, and then to fix the spiral. The second method is convenient because the doctor immediately recommends the necessary contraceptive pills, which you will take according to the plan at home.

Currently, any drug for emergency contraception after unprotected sex uses a hormonal component, which can be progesterone or levonorgestrel. Available everywhere contraception under the following trade names:

• Escapelle.
• Postinor.

Both use levonorgestrel as an active component, only Postinor contains 0.75 mg, and Escapel contains 1.5 mg, which determines the peculiarities of their use. The mechanism of action is the same.

Levonorgestrel prevents the development of ovulation and the release of the egg from the ovary, which is the main contraceptive effect. A sperm that enters the uterus after unprotected sex will die after some time without fertilizing the egg. In addition, the data emergency contraceptives will contribute to an increase in the viscosity of intracervical mucus, which will create a mechanical obstacle to the movement of sperm into the uterine cavity.

Levonorgestrel prevents the development of ovulation and the release of an egg from the ovary.

How to take and what is the effectiveness

It should be noted that these concepts overlap. The relationship between the increase in the contraceptive effectiveness of pills and the time of taking them has long been noted: the earlier the drug was taken after unprotected sexual intercourse, the less chance development of pregnancy.

According to the annotations of manufacturers of tablet postcoital contraceptives, the maximum interval between unprotected sexual intercourse and taking the drug is 72 hours. Further use of this method of protection is inappropriate.

Emergency tablet contraceptives (features of administration)

The instructions for use indicate that if vomiting occurs in the first 3 hours after taking birth control pills, take medicinal product needs to be repeated.

When not to use

First of all, these will include an already confirmed pregnancy. These contraceptive pills do not have an abortifacient effect, so they cannot be used to get rid of an unwanted pregnancy. Medical contraindications in the annotations for both contraceptive drugs are indicated as follows:

• An allergic reaction, which has already occurred or is potentially possible, to active substance levonorgestrel or any other component of the tablet.
• Gastrointestinal pathology ( gastrointestinal tract). In some diseases, absorption function is impaired small intestine, which leads to the fact that the required concentration of the hormone in the blood is not achieved. The contraceptive effect of contraceptives in this case is difficult to predict. Example similar diseases is Crohn's disease.
• Serious liver pathology with signs of liver failure, in which there is a decrease in liver function.
• Emergency contraceptives in the form of tablets cannot be taken together with medications for the treatment of HIV, tuberculosis, fungal diseases (meaning oral capsule or tablet forms), epilepsy, barbiturates and St. John's wort preparations.

If you doubt that emergency remedy contraception is compatible with your medical condition, discuss this issue with your doctor.

Adverse reactions

In the case when postcoital contraceptive pills are taken no more often than once every six months, no undesirable consequences are generally observed. However, a small number of women complained of headache or dizziness. Vomiting, nausea or diarrhea may also occur. Reactions from the reproductive system are somewhat more common:

1. Bleeding.
2. Pain in lower sections abdomen caused by myometrial spasm.
3. Dysmenorrhea.
4. Absence of regulation for 7 or more days, which is a reason to contact an obstetrician-gynecologist to exclude pregnancy. For the same purpose, a woman is recommended to undergo an ultrasound examination.

Adverse reactions have every chance of causing abdominal pain, this happens due to myometrial spasms.

Menstruation that is very different from usual will also be a reason to consult a doctor. This is manifested by the occurrence of slight bleeding during regulation.

Less commonly used tablet forms

To prevent pregnancy after unprotected intercourse, mifepristone drugs are also used ( trade name Genale products). It increases the contractility of the myometrium (the muscular layer of the uterus), changes the structure of the endometrium, into which the egg is normally implanted, and prevents ovulation. It is recommended to use Mifepristone in the first 72 hours after unprotected sexual intercourse.

The annotation for Zhenale lists the following adverse reactions:

1. Allergic reactions of varying intensity.
2. Pain in the lower abdomen due to spastic contractions of the myometrium, bleeding.
3. Exacerbation of chronic inflammatory diseases woman's genitals.
4. From the gastrointestinal tract: diarrhea, vomiting or nausea.

Mifepristone is used somewhat less frequently than levonorgestrel drugs and due to its more wide range contraindications. They cannot be recommended for women with anemia, renal or liver failure, porphyria, other serious pathologies internal organs and systems.

Breastfeeding is a categorical contraindication to the prescription of mifepristone, but levonorgestrel can be used for emergency contraception in lactating women. A necessary condition for this is to take it after feeding the child.

Depending on the markup category of pharmacies, the price of Postinor ranges from 320 to 350 rubles, and Escapela 310–365 rubles. The cost of mifepristone drugs is 300–340 rubles.

It is up to you to decide which method of emergency contraception to choose. Whatever method you choose, emergency contraception is a much easier way to prevent unwanted motherhood than having an abortion or a vacuum after. Take good care of your health.

Situations often occur when, during sexual intercourse, the condom is damaged, which entails the entry of sperm into the woman’s body. Even more often, there are times when during sexual pleasure one simply forgets to use contraception. And besides, having sex without a condom is much more enjoyable. But such careless moments have one consequence - an unwanted pregnancy. What to do next?

The consequences of unprotected sexual intercourse can be corrected with the help of medical supplies, which are called emergency pills. They are created specifically to correct unprotected sexual intercourse, which entails the occurrence of unwanted pregnancy.

Such remedies are used only when absolutely necessary, when a woman is sure that conception can occur. Just drinking them “just in case” is very dangerous for health and can cause irreparable harm woman's life.

Such pills are also called day-after pills, providing contraception for 72 hours. It is during this time after sexual intercourse that the effect of the medication is determined.

Important! The high effectiveness of not getting pregnant after taking the emergency pill is due to the first day. On the second and third days, performance indicators decrease by 15-20%, respectively.

If you are really afraid of getting pregnant, and in no way want to let this happen, then you need to take the pills on the first day. If the medication was taken on the third day, then its effectiveness is no more than 50%. If pregnancy still occurs after unprotected sexual intercourse, then there is no point in using pills.

Important! The pills are called emergency because they provide a fast-acting effect that helps prevent the fertilization of an egg by sperm that has entered a woman’s body.

Types of emergency contraception medications

1. 24-hour drugs. The need to take such tablets immediately after intercourse, as well as after the event for the above-mentioned time.
2. 72-hour effect of medications. If more than 24 hours have passed since the act of carnal pleasure, then a 72-hour remedy will help.
3. There are also means to prevent pregnancy even after three days. These include a copper-containing spiral. The main advantage of such a spiral is its functionality even after 5 days after intercourse.

In case of rape, the installation of a spiral is not allowed, as it can lead to infection of the body.

Let’s take a closer look at the pills that are classified as 24- and 72-hour emergency medications for pregnancy.

Effect of emergency drugs

The effect of contraceptive medications after intercourse is determined by the following important responses:

1. A fence is carried out, which is characterized by the inadmissibility of the ovaries leaving the egg.
2. Limit the meeting of sperm and egg.
3. If the egg has already been fertilized, then the drugs prevent it from entering the uterus.

Thus, when a woman takes the medication, the following effect occurs in her body: thickening of the mucous secretion in the cervix. These clots that form are a barrier to sperm. It is in this way that emergency contraceptives function.

For your information! There are two types of emergency medications for conception: estrogen-containing and non-hormonal.

Drugs that contain estrogen are hormonal. When they are used, some types of side effects (headache, nausea, diarrhea, groin pain).

If after using the medication there is a deterioration in health, you should immediately consult a doctor. Why should you see a doctor? First of all, this is necessary to find out the cause of the disease, because side effect may indicate an ectopic pregnancy. Often, after taking the drug, a woman may feel pain in the chest, arms, shoulders, legs or arms. Such symptoms indicate an incorrect dosage of the drug.

Let's take a closer look at the 72-hour and 24-hour tablets, as well as their names.

72 hour tablet

If sexual intercourse occurred more than 24 hours ago, then the 72-hour pregnancy medication is suitable in this situation. By taking the pill within this period of time, you can stop the phenomenon of conception.

They are characterized by high hormonal activity, so they can be taken no more than four times a month. The most common of this series of tablets are the following drugs: PostinorDuo and Escapelle, Genale.

Taking the drug often causes the following complications:

1. Strong painful sensations in the abdominal area. Appear 3-5 weeks after using the product. Most often it indicates ectopic pregnancy. Requires immediate hospitalization.
2. Difficulty breathing and blurred vision.
3. Allergic rash and chest pain.

To avoid or reduce actions side effects, you should take the drug under medical supervision.

It is used in cases where protective measures were ineffective and allowed sperm to enter the woman’s body. Active component The drug is lovonorgestrel. The drug does not allow fertilization of the egg, and if a phenomenon occurs, it is capable of rejecting the embryo from the body. The effectiveness of the drug is determined by the time it is taken after sexual intercourse; the earlier, the greater the likelihood of not getting pregnant. It has virtually no negative side effects.

A drug based on histamines, which is determined by its effectiveness for 72 hours, but no later. It is a potent component because it contains synthetic substances. Helps inhibit the ovulation process, as well as the rejection of a fertilized egg. The drug is characterized by these types of contraindications, manifested in the form of discharge blood clots from the vagina, unbearable pain in the groin area, as well as pathological abnormalities.

PostinorDuo

The postinor tablet consists of the hormone levonorgestrel. This is a synthetic analogue of the hormone that does not allow fertilization of the egg after sexual intercourse for 72 hours. Levonorgestrel is still used in the main means of contraception, which are taken before sexual pleasure, only the dose of its content is much lower than in the drug Postinor.

The postinor package contains two tablets that are recommended for use:

The first - after intercourse (and the earlier, the better).
The second - after 12 hours.

Important! It is necessary to repeat the drug intake if at least one of the tablets was removed from the body through vomiting. Vomiting may occur if the tablet is not absorbed.

Postinor refers to drugs that are not able to save a woman from an already established pregnancy. It is worth noting this situation: if you took Postinor after sexual intercourse, and a couple of days later you had sex again without using protection, then in this case the drug will not save you from a second fertilization.

If, after taking Postinor, an unwanted pregnancy is detected, you should immediately consult a doctor. This drug may increase the risk of ectopic pregnancy. The doctor will conduct an examination and determine the location of the fetus.

Tablet 24 hours

24 hours is a tablet that is characterized by its effectiveness within 24 hours after sexual intercourse. Most often used:

1. When carnal pleasures occurred without means of protection.
2. When protective equipment has been damaged.
3. In case of rape of a woman.

Before the embryo develops, the pill is 95% effective, and after that it is zero. When taking medication, you should be 100% aware that the embryo has not yet formed.

It has a number of side effects:

• Vomiting, groin pain, diarrhea, cramps
• Dizziness and fatigue
• Vaginal pain and menstrual irregularities

Vaginal tablets

You can get rid of unwanted pregnancy using vaginal tablets. They are characterized by a not so large percentage of legal capacity, which is 80-85%, but are absolutely safe for women. The active substance of the drug, after its use, helps to block sperm, thereby reducing the risk of fertilization of the egg.

Also the main features include the absence negative effects, which allows you to take the drug at any time of the menstrual cycle. TO vaginal tablets relate:

• Pharmatex
• Benatex
• Ginakotex

These tablets are non-hormonal substances, which makes them safe, but the effectiveness of such drugs lies to a greater extent in joint reception with other contraceptives.

Most representatives of the fair sex do not rely on “maybe”, but take all available measures to prevent the occurrence of an unplanned pregnancy. And yet no one is immune from the circumstances in which unprotected sex can happen. What actions should be taken in this situation? Which contraceptives Can I use it after unprotected intercourse? This article is devoted to these issues.

Today it is hardly possible to meet a family in which the birth of a child was not planned in order to avoid an unwanted pregnancy. After all, the consequence is a barbaric method of artificially interrupting it. For this purpose, a lot of contraceptive methods have been developed and continue to be developed.

If you follow the instructions for their use and listen to the advice of doctors, you can avoid pregnancy in almost one hundred percent of cases. But no one is immune from force majeure circumstances. Life is full of surprises, and sometimes it is not possible to avoid unprotected sex.

It is precisely for such unforeseen cases that they exist. emergency types contraception - contraceptives, the use of which is intended after unprotected sexual intercourse. There are three ways to avoid pregnancy in this situation:

• accept hormonal pills,
• insert an intrauterine device,
• apply douching.

There is also a fourth way - immediately after unprotected intercourse, insert contraceptive suppositories into the vagina. However, this is more of a fantasy, since in order to get the expected effect, this must be done within a maximum of one hundred seconds after the sperm enters the cervix. The same can be said about the effectiveness (or rather the lack thereof) of douching.

The expected result can be obtained if, after sexual intercourse, intrauterine devices are used as contraceptives. But here two questions arise:

• Is it possible to do this as soon as possible,
• whether the lady intends to use this contraceptive in the future on an ongoing basis.

Whatever one may say, but the best remedy To prevent pregnancy immediately after unprotected intercourse, gestagenic and antigestagenic hormonal contraceptive pills are used.

Non-hormonal birth control pills are used before, not after, sexual intercourse.

Is it possible to take birth control pills after intercourse?

To the question whether it is possible to take hormonal contraceptive pills after sexual intercourse, you can give a clear answer: not only is it possible, but it is also necessary if you want to prevent pregnancy. They are not dangerous even for ladies who have health problems. But several side effects may still occur. This:

• weakness,
• dizziness,
• pain in the lower abdomen,
• irregular bleeding
• increased breast sensitivity,
• nausea.

FECs are intended for one-time use. Their frequent use leads to very disastrous consequences.

Any specialist, when asked by a patient whether it is possible to take hormonal contraceptive pills after sexual intercourse, will answer: it is possible, but wisely and only in extreme cases. in case of emergency. Studies have not confirmed the possibility of them causing harm to the fetus if pregnancy does occur. Emergency contraceptive pills taken after unprotected intercourse cannot interrupt it either.

When should you take birth control pills after intercourse?

Depending on what kind of post-coital contraceptive pills we are talking about, they are used various schemes, which describe when and how much to drink after an unprotected act. But there is one thing that unites them all: you need to take the pills as soon as possible after sex. Only then can we hope that they will have the desired effect. The dosage regimen for the most popular medications is as follows:

1. Postinor is taken as follows: the first tablet - within 72 hours after sex, the second - twelve hours after the first.
2. Eskinor F and Escapelle - one dose within seventy-two hours.
3. Medicines containing mifepristone (Zhenale, Ginepristone, Mifolian, etc.) are taken once in one dose for a maximum of three days after sex. In this case, you should refrain from eating for two hours before and after consuming it.
4. COC tablets with gestagen and estrogen are taken according to the so-called Yuzpe method: the first 72 hours - 2 or 4 tablets (depending on the amount of hormones they contain); after 12 hours - two or four more tablets.

Preparations containing Mifepristone (ATC code G03XB01) at a dose of 10 mg
Name, manufacturer	Release form	Pack, pcs.	Price, r
Gynepriston, Russia, Mir-pharm	tablets 10mg	1	330-690
Zhenale, Russia, Izvarino Pharma	tablets 10mg	1	260-570
Agesta, Russia, Biochemist	tablets 10mg	2	No
Preparations containing Levonorgestrel (Levonorgestrel, ATC code G03AC03)
Name, manufacturer	Release form	Pack, pcs.	Price, r
Common release forms
Postinor, Hungary, Gedeon Richter	tablets 0.75 mg	2	305-610
Escapelle, Hungary, Gedeon Richter	tablets 1.5 mg	1	360-670
Rare and discontinued release forms
Escinor-F, India, Fami Ker	tablets 0.75 mg	2	No

Commercial names abroad (abroad): Mifepristone drugs - Korlym, Mifeprex; Levonorgestrel drugs - Plan B, Next Choice, Postinor.

Answers from the site author to typical visitor queries:

If sex occurs for three days, how many Postinor tablets should you take?

If by three days we mean three days (72 hours), then the manufacturers of Postinor do not guarantee anything in such a situation; the period of admission stated in the annotation is up to 72 hours. You can try taking a pill, then the next one 12 hours later, but the result is very doubtful.

When can you have sex after using Postinor?

You can take it right away, but the manufacturer recommends sex first, then Postinor.

Which is better: Postinor or Gynepriston?

Genale or Postinor?

Ginepristone and Zhenale are not hormonal drugs, so in general they cause significantly less harm hormonal system women than Postinor.

Can I take emergency contraceptives while breastfeeding?

How long after taking Postinor tablets can I breastfeed?

Emergency contraception and breastfeeding are incompatible things. That is, of course, you can accept it, but breast-feeding will have to stop for a while. In the case of Prem Postinor, this period is 24 hours, but for Zhenale and Gynepriston it is much longer - a break of 2 weeks is needed.

Gynepristone: how long does it take for side effects to appear?

Gynepristone: is bleeding possible after use?

Side effects may appear almost immediately (nausea, pain in the lower abdomen) or within a day to a week (bleeding).

How long after intercourse should you take birth control pills?

The earlier the better. As the period increases, the effectiveness decreases. Manufacturers of all drugs state a maximum period of 72 hours (three days), after which the likelihood of pregnancy increases significantly.

Which is better: Postinor or Escapelle against pregnancy?

In terms of effect, they are approximately equivalent, since they contain the same active substance. Postinor contains half as much of it, so it must be taken in the amount of TWO tablets with an interval of 12 hours. Escapelle is taken ONE tablet at a time, which makes it more convenient.

Will Postinor be effective after three unprotected sexual intercourses?

If you take it on time, it will most likely happen.

Is it possible to leave the baby after taking emergency contraceptive pills?

Postinor and Escapelle have virtually no effect on a completed pregnancy, but in the case of Ginepriston and Zhenale the situation is worse. These drugs are antagonists of the pregnancy hormone progesterone, with their help in more high doses pregnancies are terminated, so if the pregnancy continues, unpleasant surprises are possible (it is unknown how an “uninterrupted” pregnancy will develop).

Is it possible to shift critical days after Postinor?

Possible up to a week in a rare case up to 10 days. From the first day of the delay, you can use a pregnancy test to clarify the situation.

Postinor - doctor's review

The drug is very old, back in the mid-eighties of the last century it was actively sold in pharmacies Soviet Union and was widely used by the population.

The drug fulfills its task, especially with early (first - maximum second day after the act) use.

Among the unpleasant aspects of his action, I would like to note the following. Taking Postinor deals a rather heavy blow to the “heart” of a woman. reproductive system- ovaries. This most often manifests itself in the following:

When taken once, and even more so repeatedly, it delays the onset of the next menstrual bleeding, and the woman simply does not understand what phase of the cycle she is in at the current moment. Hence the impossibility of understanding whether madam is pregnant or not, and whether unprotected sex Today. And bleeding can be expected at any time.

In general, taking the drug twice a year is possible, more often it is extremely undesirable, and in general it is better to replace it with products containing an antagonist of the pregnancy hormone progesterone - Mifepristone (Gynepristone, Zhenale, Agesta - the second tablet on the page), they cause less impact on hormonal woman's system.

Although Ginepriston is also not honey, in some patients it gives side effects and shifts menstruation.

When taking Ginepristone, do not forget about 2 hours of fasting before and after.

And if you plan enough frequent use postcoital drugs - it is better to think about other means of contraception.

Postinor - instructions for use. The drug is a prescription, the information is intended only for healthcare professionals!

Postcoital contraceptive for oral administration

pharmachologic effect

A synthetic drug with a contraceptive effect, pronounced gestagenic and antiestrogenic properties. With the recommended dosing regimen, levonorgestrel suppresses ovulation and fertilization if sexual intercourse occurs in the preovulatory phase, when the possibility of fertilization is greatest. It may also cause changes in the endometrium that prevent implantation. The drug is not effective if implantation has already occurred.

Efficacy: with the help of Postinor tablets, pregnancy can be prevented in approximately 85% of cases. The more time passes between sexual intercourse and taking the drug, the lower its effectiveness (95% during the first 24 hours, 85% from 24 to 48 hours and 58% from 48 to 72 hours). Thus, it is recommended to start taking Postinor tablets as soon as possible (but no later than 72 hours) after sexual intercourse, if no protective measures have been taken. At the recommended dose, levonorgestrel does not have a significant effect on blood clotting factors, fat and carbohydrate metabolism.

Pharmacokinetics

At orally Postinora drug is quickly and almost completely absorbed. Absolute bioavailability is almost 100% of the dose taken. After taking 0.75 mg of levonorgestrel, Cmax in serum equal to 14.1 ng/ml is achieved after 1.6 hours. After reaching Cmax, the content of levonorgestrel decreases. T1/2 is about 26 hours.

Levonorgestrel is excreted approximately equally by the kidneys and through the intestines exclusively in the form of metabolites. The biotransformation of levonorgestrel corresponds to the metabolism of steroids. Levonorgestrel is hydroxylated in the liver, metabolites are excreted in the form of conjugated glucuronides. Pharmacologically active metabolites of levonorgestrel are unknown. Levonorgestrel binds to serum albumin and sex hormone binding globulin (SHBG). Only 1.5% of the total dose is in free form, and 65% is associated with SHBG.

Indications for use of the drug POSTINOR

• Emergency (postcoital) contraception (after unprotected sexual intercourse or unreliability of the contraceptive method used).

Directions for use and dosage

The drug is taken orally. You must take 2 tablets in the first 72 hours after unprotected intercourse. The second tablet should be taken 12 hours (but not later than 16 hours) after taking the first tablet.

To achieve a more reliable effect, both tablets should be taken as soon as possible after unprotected intercourse (no later than 72 hours).

If vomiting occurs within 3 hours after the 1st or 2nd dose of Postinor tablet, then you should take another Postinor tablet.

Postinor can be used at any time of the menstrual cycle. In case of irregular menstrual cycle, pregnancy must first be excluded.

After taking emergency contraception, a topical barrier should be used until the next menstrual period. contraceptive methods(for example, a condom, cervical cap). The use of the drug during repeated unprotected sexual intercourse during one menstrual cycle is not recommended due to an increase in the frequency of acyclic spotting/bleeding.

Side effect

Allergic reactions: possible - urticaria, rash, itching, swelling of the face.

Transient side effects that occur with different frequencies and not requiring drug therapy: sometimes (1-10%) - vomiting, diarrhea, dizziness, headache, breast tenderness, delayed menstruation (no more than 5-7 days; if menstruation is delayed for a longer period, pregnancy must be excluded); often (more than 10%) - nausea, fatigue, pain in the lower abdomen, acyclic bloody issues(bleeding).

Contraindications to the use of the drug POSTINOR

• adolescence up to 16 years;
• pregnancy;
• rare hereditary diseases, such as lactose intolerance, lactase deficiency or glucose-galactose malabsorption;

With caution: diseases of the liver and biliary tract, jaundice (including a history), Crohn's disease, lactation.

Use of the drug POSTINOR during pregnancy and breastfeeding

Postinor is contraindicated for use during pregnancy. If pregnancy occurs while using emergency method contraception, then based on the available data, no adverse effect of the drug on the fetus has been identified.

Levonorgestrel is released with breast milk. After taking the drug, breastfeeding should be stopped for 24 hours.

The drug is prescribed with caution to patients with diseases of the liver and biliary tract; it is contraindicated in severe liver failure.

Data on the use of the drug in patients with impaired renal function are not provided.

special instructions

Postinor should be used exclusively for emergency contraception. Reuse Postinor is not recommended for use during one menstrual cycle.

The effectiveness of Postinor tablets after unprotected sexual intercourse, during which contraception was not used, decreases over time:

The drug does not replace the use permanent methods contraception. In most cases, Postinor does not affect the nature of the menstrual cycle. However, acyclic bleeding and a delay of menstruation for several days are possible. If menstruation is delayed by more than 5-7 days and its character changes (scanty or copious discharge) pregnancy must be excluded. The appearance of pain in the lower abdomen and fainting may indicate an ectopic (ectopic) pregnancy.

Adolescents under 16 years of age, in exceptional cases (including rape), need to consult a gynecologist to confirm pregnancy.

After emergency contraception, a consultation with a gynecologist is recommended to select the most appropriate method of permanent contraception.

Emergency contraception does not protect against sexually transmitted diseases.

In case of gastrointestinal dysfunction (for example, Crohn's disease), the effectiveness of the drug may be reduced.

Impact on the ability to drive vehicles and operate machinery

The effect of Postinor on the ability to drive vehicles and operate machinery has not been studied.

Overdose

Increased severity of side effects. There is no specific antidote. Symptomatic therapy is carried out.

Drug interactions

When taking drugs that induce liver enzymes simultaneously, the metabolism of levonorgestrel is accelerated.

The following drugs may reduce the effectiveness of levonorgestrel: amprecavil, lansoprazole, nevirapine, oxcarbazepine, tacrolimus, topiramate, tretinoin, barbiturates including primidone, phenytoin and carbamazepine, drugs containing St. John's wort (Hypericum perforatum), and rifampicin, ritonavir, ampicillin, tetracycline, rifabutin, griseofulvin. Levonorgestrel reduces the effectiveness of hypoglycemic and anticoagulant drugs (coumarin derivatives, phenindione) medicines. Increases plasma concentrations of GCS. Women taking these drugs should consult a doctor.

Drugs containing levonorgestrel may increase the risk of cyclosporine toxicity due to inhibition of its metabolism.

Conditions for dispensing from pharmacies

Storage conditions and periods

List B. The drug should be stored out of the reach of children at a temperature of 15° to 25°C. Shelf life - 5 years.

Ginepristone (Zhenale) - instructions for use. The drug is a prescription, the information is intended only for healthcare professionals!

Clinical and pharmacological group:

Antigestagenic drug. Postcoital contraceptive for oral administration

pharmachologic effect

A synthetic steroid antigestagenic drug (blocks the action of progesterone at the receptor level) and does not have gestagenic activity. Antagonism with glucocorticoids is noted (due to competition at the level of communication with receptors).

Increases myometrial contractility by stimulating the release of interleukin-8 in choriodecidual cells and increasing the sensitivity of the myometrium to prostaglandins. Depending on the phase of the menstrual cycle, it inhibits ovulation, changes the endometrium and prevents the implantation of a fertilized egg.

Pharmacokinetics

Suction

After a single oral dose of 600 mg, Cmax is reached after 1.3 hours and is 1.98 mg/l. Absolute bioavailability is 69%.

Distribution

Binding to plasma proteins (albumin and acidic α1-glycoprotein) is 98%.

Removal

T1/2 - 18 hours. Elimination is carried out in two phases: first, slow elimination of the drug (the concentration of mifepristone in the blood plasma decreases by 2 times between 12-72 hours), then a rapid elimination phase.

Indications for use of the drug GINEPRISTONE®

• Emergency postcoital contraception (after unprotected intercourse or if the method of contraception used cannot be considered reliable), as well as in case of unsuccessful use of other methods of contraception (including an error when using the calendar method, unsuccessful interruption of sexual intercourse, rupture or slipping of the condom).

Dosage regimen

The drug is prescribed orally in a single dose of 10 mg (1 tablet) within 72 hours after unprotected sexual intercourse.

To maintain the contraceptive effect, you should refrain from eating 2 hours before using the drug and for 2 hours after taking it.

Ginepristone® can be used in any phase of the menstrual cycle.

Side effect

From the digestive system: nausea, vomiting.

From the side of the central nervous system: dizziness, headache.

From the reproductive system: bloody discharge from the genital tract, menstrual irregularities.

Allergic reactions: urticaria.

Other: discomfort in the lower abdomen, weakness, hyperthermia.

Contraindications to the use of the drug GINEPRISTONE®

• adrenal insufficiency;
• long-term use of GlucoCorticoSteroids;
• acute or chronic renal failure;
• acute or chronic liver failure;
• the presence of severe extragenital pathology;
• hypersensitivity to mifepristone (history).
• severe liver failure;
• use in adolescents under 16 years of age;
• pregnancy;
• lactose intolerance, lactase deficiency or glucose/galactose malabsorption;
• hypersensitivity to the components of the drug.

The drug should be prescribed with caution in cases of impaired hemostasis (including previous treatment with anticoagulants), chronic obstructive pulmonary diseases (including bronchial asthma), heavy arterial hypertension, heart rhythm disturbances, chronic heart failure.

Use of the drug GINEPRISTONE® during pregnancy and lactation

Ginepristone® is contraindicated for use during pregnancy.

Breastfeeding should be stopped for 14 days after taking the drug.

Use for liver dysfunction

Contraindication: acute or chronic liver failure

Use for renal impairment

Contraindication: acute or chronic renal failure

special instructions

The use of Ginepristone® does not protect against sexually transmitted diseases and AIDS.

Should be avoided simultaneous administration Gynepristone with Nonsteroidal Anti-Inflammatory Drugs.

Overdose

Taking Ginepristone in doses up to 2 g does not cause adverse reactions.

Symptoms: Possible adrenal insufficiency.

Treatment: symptomatic therapy.

Drug interactions

Drug interactions with Ginepristone® have not been described.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

List A. The drug should be stored out of the reach of children, in a dry place, protected from light at a temperature not exceeding 30°C. Shelf life - 3 years