home Analyzes Is it possible to drink lozap in the evening? "Lozap" - blood pressure pills: reviews. Combination with traditional treatment

Is it possible to drink lozap in the evening? "Lozap" - blood pressure pills: reviews. Combination with traditional treatment

Lozap - blood pressure tablets based on losartan potassium and:

microcrystalline cellulose (0.052 g);
crospovidone (0.005 g);
magnesium stearate (0.002 g);
silicon dioxide (0.001 g);
talc (0.002 g).

The tablets are film-coated, consisting of white sepifilm 752 in an amount of 4.95 mg and macrogol 6000 in an amount of 0.5 mg.

Available in cardboard packages, they can contain 2, 4, 3, 6 and 9 blisters of 10 or 15 tablets. Dosages of 12.5, 50 and 100 mg.

Lozap plus blood pressure tablets have a biconvex shape and White color.

Lozap tablets for the treatment of high blood pressure

pharmachologic effect

The medicine is an excellent receptor antagonist.

People who have arterial hypertension, but do not have diabetes mellitus and proteinuria at the same time, can use this drug in order to reduce proteinuria, immunoglobulin G and albumin excretion.

After one-time use of the drug, blood pressure decreases noticeably. Maximum effectiveness is observed within 6 hours; within 24 hours, blood pressure normalizes.

To achieve a permanent effect, the drug must be taken for 21-42 days.

Pharmacodynamics and pharmacokinetics

The drug does not negatively affect the enzyme kininase, which catalyzes angiotensin 1 into angiotensin 2. The drug helps reduce peripheral resistance in blood vessels, and well normalizes aldosterone and adrenaline in the body.

By using Lozap you can reduce the risk of developing diseases such as myocardial hypertrophy and increase the perception of physical activity those people who have heart failure. These tablets do not reduce speed in any way. chemical reactions angiotensin-converting enzyme - kininase 2, and therefore cannot prevent the breakdown of bradykinin. Thus, negative impact drug that may be related to bradykinin is unlikely.

The drug is prescribed by the attending physician

The drug is absorbed quite well from the gastrointestinal tract. It initially enters the liver and is then carboxylated by complex protein molecules, enzyme-catalyzed atoms or oxygen molecules into an oxidizing substrate.

The maximum concentration of losartan is one hour, the active metabolite occurs three to four hours after taking the medicine.

35% of it is utilized during urination and 58% of the drug is excreted through the intestines.

Cases of prescribing tablets

They should be used by people with arterial hypertension, as well as people with heart failure.

The drug is often prescribed to reduce possible development diseases associated with heart and vascular diseases. It can also be taken by people with hypertension or significant enlargement of the ventricle (left). When using these tablets, the number of deaths is significantly reduced.

People who have type 2 diabetes and true hypertension often take this medication to reduce the development diabetic nephropathy. Also used by patients with nephropathy in diabetes, having 0.3 g/g or more in the urine of substances such as creatinine and albumin.

Application Guide

Many patients do not know how to take Lozap for blood pressure, and therefore do not achieve the required positive result.

You can take the drug at any time of the day

Medicines can be taken at any time of the day, even during meals or after. But only once every twenty-four hours.

Patients with arterial hypertension should take 0.05 g of Lozapa. With the progression of this disease daily norm doubled.

Initially, doctors prescribe 0.013 g, but can double it. If a patient who is already taking diuretics consults a doctor, then Lozap is prescribed 25 mg. daily. Elderly patients do not require dosage adjustment.

If the drug is prescribed to reduce the possibility of diseases associated with the heart and blood vessels (for example, stroke or heart attack), then it is necessary to start with 0.05 g. If there is no improvement, then add additional medications or the dose of Lozap is doubled.

The same dose of 0.05 g once every 24 hours is prescribed to people who have stage 2 diabetes and proteinuria. The dosage can be increased in the same way.

A lower dosage level is prescribed to patients who have different liver diseases, dehydration or extrarenal blood purification due to the presence of chronic and acute disorder kidney function, in addition, this group includes patients aged 74 years and older. They are prescribed a dose of 0.025 g daily.

Lozap instructions for use, at what pressure should the drug be used? It is prescribed for excessively high blood pressure, the norm of which is individual for each person.

The average pressure, according to the World Health Organization, should be about 120/80 millimeters of mercury.

For excessively high blood pressure, Lozap is prescribed

Use of the drug in the elderly and children

For young patients and underage teenagers It is not recommended to take the drug for hypertension.

Use of the product during pregnancy and lactation

Lozap is not used during lactation or pregnancy. It can cause serious problems in fetal development and lead to negative consequences while breastfeeding.

Consequences of non-compliance with dosage

At excessive consumption Lozap will cause bradycardia, tachycardia and too much reduction in pressure in the arteries.

If the dosage is too low, the hypertension will not be treated.

Dizziness is considered the most common symptom with excessive use of Lozap

Undesirable manifestations

The most common medical symptom is dizziness.

Patients sometimes experience fatigue, pain in chest, increased heart rate, unpleasant sensations in the abdominal area, nausea, diarrhea, cramps, insomnia, constipation, allergic reactions, anemia, anxiety, cough and nasal congestion. Other symptoms also occur, but they are extremely rare.

Cases in which this drug is strictly contraindicated

The drug should not be used:

pregnant women;
nursing mothers;
minors;
people with intolerance to one of the constituent components.

special instructions

Before prescribing the drug, dehydration correction is usually carried out. If not available, the medicine is prescribed in a minimum dosage.

Those who have renal stenosis and only one kidney with a similar disease should be more careful.

If a sick patient has liver problems (cirrhosis is the most common), the medicine should be taken in small doses.

The drug should not be used during pregnancy

Interaction with other drugs and alcohol

The medicinal product can be used in combination with similar drugs. Then the patient will receive an enhanced effect.

Components such as:

may be included in medications that are used simultaneously with Lozap.

When prescribing the drug Lozap, the instructions for use are necessary for mandatory study in order to determine at what pressure to use the medicine specifically for your body, and whether it increases or decreases blood pressure.

Angiotensin II is one of the stress hormones that are produced by the body in times of danger. Stress hormones are also released when we are under constant pressure at work or at home. The secretion of hormones such as adrenaline, cortisol and angiotensin 2 prepares the body to deal with these situations by increasing blood pressure, speeding up the blood and increasing heartbeat.

According to patients who took Lozap for high blood pressure, there are very often counterfeits that do not reduce blood pressure. This phenomenon is normal; to avoid counterfeit drugs, choose pharmacies carefully. Do not try to stop taking the drug yourself; withdrawal syndrome may occur.

What better than Lozap or , and what's the difference? Lorista has a diuretic effect, but Lozap does not. Compatibility and Lozapa improves the functioning of both drugs in patients.

Lozap is used to reduce the effect of adrenaline and norepinephrine on the heart, makes it beat slowly and less actively, this reduces blood pressure, Lozap can be used to reduce high blood pressure. Lozap can affect potency.

Indications for use

Lozap is an antihypertensive honey. remedy, acts and is prescribed for the treatment of increased blood pressure. Which group does it belong to - the group of angiotensin II receptor antagonists. The drug is used on the recommendation of cardiologists if the patient:

High blood pressure increases a person's risk of developing these diseases. Usage drug treatment reduces the risk of these complications.

Video

Composition of the drug Lozap

Active ingredient: losartan. And other components that affect the structure of the drug, appearance tablets, consistency (hypromelose, talc, etc.). You can find out on Wikipedia how to drink the latest generation Lozap.

Lozap, Losartan or which is better, and the differences? Losartan is the active ingredient of Lozap, in combination with a diuretic, Lozap has best action on high pressure for hypertensive patients.

What doctors say about hypertension

Doctor medical sciences, Professor Emelyanov G.V.:

I have been treating hypertension for many years. According to statistics, in 89% of cases, hypertension results in a heart attack or stroke and death. Currently, approximately two thirds of patients die within the first 5 years of disease progression.

The next fact is that it is possible and necessary to reduce blood pressure, but this does not cure the disease itself. The only medicine that is officially recommended by the Ministry of Health for the treatment of hypertension and is also used by cardiologists in their work is. The drug acts on the cause of the disease, making it possible to completely get rid of hypertension. Moreover, within federal program every resident of the Russian Federation can receive it FOR FREE.

Release form, dosage and price of the drug

The annotation for Lozap provides a description of the drug, how to take it correctly, the system of application, and side effects. Number of tablets per package: 30/60/90 pieces.

Dose	Average price/RUB
50 mg	280-704 rub.
100 mg	RUB 312-756
12.5 mg	203-508 rub.

Important! According to Decree No. 56742, until June 17, every diabetic can receive a unique medicine! Blood sugar is permanently reduced to 4.7 mmol/l. Save yourself and your loved ones from diabetes!

Dosage Lozap

Adults:

Initial dose is once daily (25 mg in patients with dehydration or other drugs with diuretic effects).
The medication can be taken up to twice a day (halved), with gradual increase doses. Does not mix with alcohol.

Take before/after meals, morning/evening - your choice.

In the treatment of high blood pressure, the drug is absorbed from the gastrointestinal tract and begins to act in two hours, blood pressure reaches the desired limit after 4-6 hours, and the effect of the drug continues in the body throughout the day. Effect of use medicinal product appears after a week, sometimes its effect reaches its maximum within 3-6 weeks.

Children (age 6 years and older) for the treatment of hypertension:

The initial dose is 0.7 mg/kg body weight and can reach 50 mg/day.
Maximum daily dose does not exceed 1.4 mg per kg of weight or 100 mg/day.
Can be used in the form of tablets or syrup.
Prohibited for use by children under 6 years of age.

Dosage adjustment in patients with kidney problems:

No correction is required in case of kidney problems in adults.
In case of minor kidney problems, the drug is not suitable for use.

Dosage adjustment in patients with liver problems:

In adults with liver problems, the dose is reduced to 25 mg once daily.
In children with liver problems, use caution and adjust the dose according to the liver's response.

Contraindications

You should not take the drug if you have the following symptoms:

Side effect

All possible side effects The drug is indicated in the annotation and is purely individual.

Call your doctor immediately if you notice any of the following: side effects:

A sore throat.
Inflammation of the stomach.
Inflammation of blood vessels.
Chest pain (angina).
Muscle pain.
Cough.
Convulsions.
Nightmares.
Backache.
Hair loss.
Rash.
Hallucinations.
Headache.
General weakness of the body.
Dyspnea.
Yellowing of eyes and skin.
Dizziness.
Heartburn.
Urinary tract infection.
Anemia (anemia).
Sleep disturbance.
Lack of blood sugar.
Low blood pressure.
Diarrhea.
Renal dysfunction.
Trouble swallowing.
Negatively affects potency.
Cool hands and feet.
Psoriasis.
Confusion.
Vascular edema.
Nausea.
Tremor.
An increase in the proportion of potassium in the blood.
Fatigue.
Deterioration in the health of patients with renal failure.

Video

Lozap compatibility

To avoid problems with the compatibility of medications taken, Tell your doctor the full list of medications in your diet:

The drug Lozap has an additional effect with other drugs that lower blood pressure.
Exists increased risk slow heart rate and heart block.
When combined with lithium, the drug increases lithium levels in the body and can cause lithium poisoning.
There are no problems with the use of: cimetidine, warfarin, digoxin, hydrochlorothiazide.
Diabetes (this drug may mask symptoms of hypoglycemia such as increased heart rate and tremor, and the dose of your diabetes medication may need to be modified).
Hyperthyroidism (this drug may mask symptoms of thyroid problems).

Overdose

Lozap can cause symptoms such as: low blood pressure, increased heart rate, decreased heart rate, loss of consciousness.

At large doses The possibility of using active carbon, intestinal or ventilatory purification, as well as correction of blood electrolytes, should be considered if it is necessary to control the amount of urine.

Warnings when taking Lozap

You should not stop taking this medicine suddenly, especially if you have ischemic disease heart (insufficient blood flow to the heart, angina). When drug treatment is stopped, it should be withdrawn gradually, usually over 1-2 weeks.

While taking this medicine, you should have regular blood tests to monitor your kidney function and the levels of salts such as potassium and sodium in your blood. You should immediately consult a doctor if you have: thirst, lethargy, confusion, weakness and drowsiness, muscle cramps, low urine output, abnormal heart rhythm, nausea and vomiting.

Should not be taken with alcohol.

Use of the drug Lozap during pregnancy and lactation

This medicine should not be used during pregnancy. May increase the likelihood premature birth or death. It may also slow the baby's heartbeat, cause low blood sugar, or limit his growth in the uterus.

This drug gets into breast milk. Because this may slow the fetal heart rate or low level blood sugar, it is recommended that this drug not be used by nursing mothers. May also reduce breast milk production.

Precautions for Lozap:

Use with caution if renal artery narrowed and avoids use of Lozap with bilateral renal artery stenosis.
Caution must be exercised when performing potential dangerous species activities such as driving a car or operating equipment.
This drug should not be taken to treat angina attacks, and it does not work quickly enough. Lozap should be used regularly to prevent angina attacks.
If you go to the hospital or dentist for procedures, you should tell the doctor that you are taking Lozap.

Analogues of the drug Lozap

What are the analogues:

Lisinopril.
Losarel.
Amlodipine.
Alzap.
Enalapril.

Be careful! Beware of fakes.

Every year the number of people suffering from low or high blood pressure and heart failure is growing. And this is not surprising: poor environment, hard work, weather conditions, bad habits, negative emotional states(depression, stress, tension, etc.) - all this leads to the fact that the body cannot stand it and manifests itself with negative side. As a result, a person’s blood pressure begins to fluctuate and the heart functions poorly. What miracle pill here can have a beneficial effect on the body? The drug “Lozap” will come to the rescue, international name main active substance which contains losartan. It is this medication that can cope with such health problems. Therefore, today we will consider the main aspects regarding the drug “Lozap”: analogues, price, indications, side effects of the drug.

Pharmacokinetics

After taking this medication orally, it is quickly absorbed gastrointestinal tract. 33% of the drug reaches the site of its action. Maximum time achieving the desired effect from taking the medicine is 1 hour, the period of active metabolism is 3-4 hours. Approximately 35% of the dose is excreted in urine and 60% in feces.

For what diagnoses is it prescribed?

The drug "Lozap", reviews of which can be read in this article, is prescribed to patients in the following cases:

for the treatment of arterial hypertension;
with heart failure;
to reduce the risk of cardiovascular complications.

Effect of the drug

Lozap tablets have the following effects on the body:

Reduce proteinuria, albumin and immunoglobulin G excretion.
Inhibits the development of myocardial hypertrophy.
Increases resistance to various loads in people with heart failure.
Reduces blood pressure.

Lozap tablets, the action of which is aimed at treating patients with various ailments hearts, should be prescribed strictly by a doctor, since they have pronounced side effects. And the drug should be taken under the supervision of a specialist.

Special instructions

While using the medicine, you should periodically check the level of potassium in the blood, especially in cases of impaired renal function and in elderly patients. The drug does not in any way affect the ability to concentrate attention or the speed of psychomotor reactions.

Pills "Lozap": application drug

This medicine It is prescribed once a day at any time: before, during or after meals. When treating hypertension, the daily dose of the drug is 50 mg. However, if necessary, the doctor can increase the amount of medication to 100 mg. If a patient has chronic heart failure, doctors recommend taking up to 12.5 mg of the drug per day. Patients with kidney and liver diseases, as well as the elderly, are prescribed a lower initial dose of the drug - 25 mg per day.

If this drug is prescribed to people to reduce their risk of heart disease and vascular diseases, including stroke, then standard reception is 50 mg per day.

If the patient has type 2 diabetes mellitus, then the initial dose of the drug should be 50 mg once a day, if necessary it can be increased to 100 mg per day.

Release form

Lozap blood pressure tablets are sold in blister packs of 10 pieces, of which there can be 3, 6 or 9 pieces in a pack. These pills are round, with a core of the same color at the break. The drug is produced in the form of specially coated capsules containing 12.5 mg, 50 mg and 100 mg of potassium losartan.

Who should not take the medicine?

Not all people can take Lozap tablets. What these pills treat is already known, but about which categories of people should not use them, read below:

Women during pregnancy.
Breastfeeding mothers.
Persons who have increased sensitivity to the active component of the drug - losartan potassium or to any other excipient.
Children under 18 years old.

People who have kidney or liver failure, you should use this medication very carefully.

Use during pregnancy

As stated above, the drug "Lozap" is prohibited for pregnant women. But why? It turns out that this remedy, when used from the 4th month of pregnancy, can cause developmental defects and even fetal death. Therefore, if a woman knows that she will soon become a mother, she should immediately stop taking these pills.

If a representative of the fair sex who is breastfeeding a baby has problems with her heart or blood pressure and the doctor prescribes the drug “Lozap” to her (or she purchased it herself), then she should make a decision for herself: either stop breastfeeding, or stop swallowing tablets and replace them with another medicine.

Pills "Lozap": side effects actions

This medicine has a complex effect, therefore unwanted effects possible from outside various systems body. And now we’ll find out what problems a person taking these pills might have.

1. From the side nervous system, as well as sensory organs:

fatigue;
insomnia;
dizziness;
memory problems;
migraine;
loss of strength, blues;
tinnitus;
toothache;
deterioration of vision, the occurrence of conjunctivitis;
taste disorder.

2. Problems with the respiratory system:

nasal congestion;
cough;
sore throat;
the occurrence of sinusitis, pharyngitis;
the appearance of bronchitis, rhinitis.

3. From the gastrointestinal tract:

heartburn, belching, feeling of pressure in the abdomen, rumbling, flatulence;
nausea and even vomiting;
diarrhea or, conversely, constipation;
dry mouth;
the appearance of gastritis.

4. Problems of the musculoskeletal system:

convulsions;
pain in the back, chest;
aches in knees, shoulders;
arthritis.

5. From the cardiovascular system:

tachycardia;
arrhythmia;
angina pectoris;
anemia.

6. Problems of the genitourinary system:

frequent urge to urinate;
renal dysfunction;
dulling of the desire to have sex;
sexual impotence.

7. For the skin:

increased sweating;
dry skin;
rush of blood;
urticaria, rash, itching;
swelling of the face, lips, tongue.

What Lozap tablets are and what they are prescribed for is clear; now we should consider analogues of this remedy. So, drugs with the same active ingredient have the following names: tablets “Bloktran”, “Vasotens”, “Zisakar”, “Lakea”, “Lorista”, “Lotor”, “Presartan”, “Renicard”.

According to the mechanism of action, the following drugs are similar: “Aprovel”, “Valz”, “Valsakor”, “Diovan”, “Ibertan”, “Kandekor”, “Kardosten”, “Naviten”, “Praytor”, “Tareg”, “Firmasta” .

Before changing Lozap blood pressure tablets to others that are similar in effect, you should first visit a doctor. Despite the fact that similar drugs have the same effect, you should not personally replace one medication with another.

People's responses

As the great Roman playwright Terence wrote, there are so many people, so many opinions. This clever idea also applies to the drug described in this article - Lozap tablets. Reviews from patients who have used this remedy are varied. There are patients for whom this medicine did not suit: they developed a cough, tachycardia, increased sweating etc. In this case, you can’t continue taking the pills; they should be urgently replaced with some other remedy.

But there are a considerable number of positive responses from people regarding treatment with Lozap pills. Reviews of an approving nature boil down to one thing: patients’ blood pressure decreases, the heart begins to work properly, sleep normalizes, and dizziness disappears. True, despite the fact that people speak well of these pills, they still write that they would like to not take them so often. After all, if you forget and don’t take pills for 1 day, your condition may worsen. In general, patients who have taken the drug note its excellent effect and quite reasonable price.

Price

Lozap tablets, the price of which is quite reasonable for many patients, are sold in any pharmacy and are available without a prescription. Cost of medicine in various institutions, selling medical supplies, is not the same, it depends on the region of sale, the markup of the establishment itself. However, on average, the price of Lozap tablets ranges from 230 Russian rubles for 30 pieces of 12.5 mg each. For 90 pieces of 100 mg pills you will need to pay up to 800 Russian rubles. The price for Lozap tablets in the amount of 90 pieces of 50 mg each will be approximately 700 Russian rubles.

Some pharmacies offer various promotions and discounts on their products to attract customers. Therefore, sometimes it is possible to buy this medicine at a lower price.

Overdose

If Lozap tablets, reviews of which have both positive and negative, are accidentally taken in large doses, then the patient may experience a pronounced decrease in blood pressure and tachycardia. In this case, treatment consists of prescribing symptomatic therapy, using diuresis (introducing a large volume of fluid into the body and using diuretics). Hemodialysis (a blood purification method) is ineffective here, so it is not used.

Duration and storage conditions

The shelf life of the medicine is 24 months if stored in a dry place protected from the sun at temperatures up to 30 degrees.

Today you have learned a lot about such a drug as “Lozap”: analogues, price, purpose, restrictions, reviews about it. We found out that Losartan tablets (this is the international name of the medication described in this article) cannot be used by pregnant women so as not to cause fetal death. We determined that people’s opinions about this drug are twofold: some praise the drug, while others speak negatively about it, since the drug causes a number of side effects. Therefore, to prevent this from happening, it is necessary to consult a doctor about the possibility of using Lozap pills.

There are many drugs available to treat cardiovascular diseases. Lozap stands out among them. This medicine is often used in cardiological practice to eliminate various cardiac pathologies and lower blood pressure. In this article we will talk about the composition, form of release, features of the product, its indications for use, possible contraindications and restrictions. We will also consider similar drugs, reviews from real patients.

Lozap – drug, which belongs to the group of antagonists of specific angiotensin receptors. Such drugs have an antihypertensive effect. These are tablets widely used in cardiology for blood pressure.

International generic name is the name of the active substance that determines the effect of the drug on the body. It often does not coincide with trade name. So, INN Lozapa - .

Form and approximate price

Produced in tablet form. One tablet may contain 12.5, 50 or 100 mg of the active ingredient. They are packaged in plastic blisters of 10 pieces. IN cardboard box may be 30, 60 or 90 tablets.

Additionally, products are produced that have a special prefix in their name. Let's look at how a medicine from this group differs from the standard Lozap:

Cost in retail sales depends on the content of the active ingredient in one tablet, as well as on their quantity in the package. Here are the average prices in Moscow and St. Petersburg:

Also, the price will be slightly different for medications containing additional substances. So, Lozap AM or Plus will cost a little more.

Composition and mechanism of action

The drug contains an active component - losartan. This is an antagonist of the receptors of a special hormone angiotensin, which contributes to the pathological development of arterial hypertension.

Losartan selectively binds only to angiotensin receptors and does not affect the activity of other hormones and ion channels. In this case, a decrease in the concentration of aldosterone is observed, which has a positive effect on the activity of the heart muscle.

The active substance is not able to inhibit ACE, an enzyme that reduces the activity of bradykinin. That is, a reverse increase in blood pressure does not occur.

The drug also contains additional components - talc, magnesium stearate, silicon dioxide, crospovidone, cellulose, hypromellose, macrogol and others. They perform an auxiliary function.

Pharmaceutical properties

The effect of the drug is as follows:

decreased blood pressure (systolic and diastolic);
beneficial effects on the cardiovascular system;
decrease in heart rate.

Enhanced hypotensive effect observed when Lozap is combined with drugs with a diuretic effect (for example, Hydrochlorothiazide).

Indications and restrictions

The drug should be used if there are appropriate indications. Most often it is prescribed for:

In some cases, medicine is used to reduce the progression of diabetic nephropathy that occurs against the background of high blood pressure, when the patient develops proteinuria and hypercreatininemia.

individual intolerance to components;
the presence of severe liver pathologies;
taking Aliskiren by patients with diabetes mellitus or renal failure;
period of bearing a child;
GW period;
childhood and adolescence.

Use the medicine with extreme caution in the following conditions:

Also limitations are advanced age, belonging to the Negroid race, and the condition after a kidney transplant.

How to calculate the dosage?

Proper use of the drug can reduce the risk of developing negative reactions to a minimum. So, the instructions for use recommend:

Patients who have restrictions due to age or health status (kidney disease, liver disease) require dose adjustment. As a rule, at first it is 25 or 50 mg.

It should be borne in mind that some drugs can enhance the hypotensive effect of Lozap, so when taking them you need to reduce the dosage. The same goes for diuretics.

Side effects and overdose

The drug may have some side effects. In this case, patients experience:

When examining a person's blood, an increase in urea, creatinine and potassium is detected. In this case, hyperkalemia, hyponatremia, and hypoglycemia develop.

In some cases, symptoms of overdose may occur. Among them:

If such signs occur, the patient should be urgently taken to medical institution. There he is prescribed symptomatic therapy.

Interaction with alcohol and medications

Before using the drug, you should be aware of its interactions with other medications. Here are some examples:

Analogs

There are drugs that can replace Lozap. These are its analogues - products that have a similar effect. Among them:

Losartan-Teva.
Vasotens.
Brozaar.
Zisakar.
Carzartan.

Often many patients are looking for Russian drugs with a hypotensive effect. The cheapest of them is Losartan. Its cost is about 80 rubles/pack.

Reviews

As a rule, doctors' reviews of the drug are positive. They highlight it high efficiency and safety. see also

Thank you

Lozap represents antihypertensive drug, intended to reduce, maintain and control blood pressure levels within normal or acceptable limits. The drug reduces both blood pressure and pressure in the pulmonary circulation, reduces the load on the heart and causes a moderate diuretic effect. In addition, Lozap prevents myocardial hypertrophy and increases tolerance to physical or emotional stress. The drug is used in the treatment of arterial hypertension and heart failure.

Composition, varieties and release form

On pharmaceutical market There are two types of the drug - Lozap and Lozap plus. These varieties differ in that Lozap contains only one active component, and Lozap Plus contains two. Moreover, the main active component in Lozap and Lozap plus is the same, and the second substance in Lozap plus is additional, enhancing the effect of the first. In this article we will consider both types of the drug, since they have almost the same effect, are indicated for use for the same conditions, etc.

Both Lozap and Lozap plus are available in a single dosage form- This tablets for oral administration. Lozap contains as an active ingredient losartan, and Lozap plus – losartan and hydrochlorothiazide. The substance losartan is an angiotensin-converting enzyme (ACE) inhibitor, and hydrochlorothiazide is a diuretic. Accordingly, losartan lowers blood pressure and reduces the load on the heart, and hydrochlorothiazide removes excess fluid from the body, enhancing the hypotensive effect of the first substance. Therefore, Lozap plus has a stronger hypotensive effect compared to Lozap, since it contains a combination active ingredients, and not just one substance.

In principle, Lozap plus was created for ease of use, since diuretics are often used to enhance the effect of ACE inhibitors. Manufacturers simply combined these components in one drug, which is very convenient for a person who needs to take only one tablet, and not two, three, etc.

Lozap is available in three dosages - 12.5 mg, 50 mg and 100 mg of losartan per tablet. Lozap plus is available in a single dosage – 50 mg losartan + 12.5 mg hydrochlorothiazide. Lozap 12.5 mg tablets have an oblong, biconvex shape, are colored white or almost white and are available in packs of 30, 60 and 90 pieces. Lozap tablets 50 mg and 100 mg have an oblong biconvex shape, are colored white or almost white, are scored on both sides and are available in packs of 30, 60 and 90 pieces. Lozap plus tablets are oblong in shape, light yellow in color, scored on both sides and are available in packs of 10, 20, 30 and 90 pieces.

Action of Lozap

The therapeutic effect of Lozap is to lower blood pressure and reduce the load on the heart. This effect The drug is provided due to its ability to suppress the activity of angiotensin-converting enzyme (ACE), which ensures the conversion of angiotensin I to angiotensin II. It is precisely because Lozap suppresses the enzyme that it is classified as an ACE inhibitor.

Due to the action of Lozap, the human body does not produce angiotensin II, a substance that constricts blood vessels and, accordingly, helps to increase blood pressure. If the formation of angiotensin II is blocked, then the vessels do not narrow, and blood pressure decreases or remains within normal limits. With regular use of Lozap, blood pressure decreases and is kept within the limits normal values. Moreover, the first hypotensive effect is observed within 1 - 1.5 hours after taking the drug and persists for 24 hours, but for a persistent decrease in blood pressure you need to take the medicine for at least 4 - 5 weeks. Lozap for lowering blood pressure is very effective in elderly and young patients suffering from malignant arterial hypertension.

By dilating blood vessels, Lozap reduces the load on the heart, which makes it easier to push blood through them. By facilitating the work of the heart, the drug increases the tolerance of physical and emotional stress in people suffering from chronic heart disease.

Lozap also improves blood supply to the heart and the intensity of renal blood flow, therefore it is successfully used in the treatment of chronic heart failure and diabetic nephropathy.

Lozap combines well with other antihypertensive drugs and has a moderate diuretic effect, due to which fluid is not retained in the body and edema does not form.

Lozap plus has a more pronounced hypotensive effect compared to Lozap, since the diuretic hydrochlorothiazide included in its composition enhances the effect of the ACE inhibitor.

Separately, it should be noted that Lozap increases the excretion of uric acid and, accordingly, reduces its concentration in the blood.

When you stop taking Lozap and Lozap plus, withdrawal syndrome does not develop.

Indications for use

Lozap - indications for use.

Arterial hypertension ;
Included combination therapy chronic heart failure;
In order to reduce the risk of cardiovascular diseases (stroke, etc.) and reduce mortality in people suffering from hypertension and left ventricular hypertrophy of the heart;
Diabetic nephropathy with hypercreatininemia and proteinuria (ratio of albumin and creatinine concentrations in urine more than 300 mg/g) in patients with type 2 diabetes mellitus, combined with arterial hypertension (to protect the kidneys and prevent renal failure).

Lozap plus - indications for use. The drug is indicated for use in the treatment of the following diseases:

Arterial hypertension;
In order to reduce the risk of cardiovascular diseases (stroke, etc.) and reduce mortality in people suffering from hypertension and left ventricular hypertrophy.

Instructions for use

Instructions for use Lozap

A Lozap tablet of any dosage can be taken regardless of food, swallowing it whole, without chewing or crushing in any other way, but with a small amount of still water (half a glass is enough). Since the drug has long-term action, then everything you need daily dosage They are taken once, that is, the tablets are taken once a day. It is optimal to take the drug every day at the same time, preferably in the evening.

Lozap dosages are determined by the disease for which the drug is taken. The course of therapy is usually long - from several months to several years. The duration of use of the drug is determined individually, based on the effectiveness/side effects ratio.

If a person has hypertrophic obstructive cardiomyopathy or aortic or aortic stenosis mitral valve, or heart failure is combined with arrhythmias or severe renal failure, then he should take Lozap or Lozap plus with caution and only under the supervision of doctors.

It is not recommended to take Lozap in combination with other ACE inhibitors (for example, Captopril, Enalapril, etc.) as this increases the risk of side effects, renal problems and hyperkalemia ( increased level potassium in the blood).

If a person is on hemodialysis, then the dosage of Lozap should be reduced by half from that recommended for the condition for which the drug is being taken.

Lozap plus can provoke an exacerbation of systemic lupus erythematosus and visual impairment due to the development of an attack of myopia or angle-closure glaucoma. If such complications develop, you should stop taking the drug and consult a doctor.

Impact on the ability to operate machinery

Lozap and Lozap plus can cause dizziness, drowsiness and fainting, which negatively affects the ability to control mechanisms, therefore, while using these drugs, it is recommended to avoid any activities that require high concentration attention and reaction speed.

Overdose

An overdose of Lozap and Lozap plus is possible and is manifested by the following symptoms:

Tachycardia (heart rate more than 70 beats per minute);
Hypotension (severe decrease in blood pressure);
Fainting;
Collapse;
Disturbances in water and electrolyte balance (decreased levels of chlorine, sodium in the blood, etc.);
Dehydration (only for Lozap plus).

If an overdose develops, it is necessary to carry out symptomatic treatment aimed at maintaining normal functioning vital important organs, as well as to restore water and electrolyte balance. So, with severe hypotension, you should lay the person on his back and raise his legs. If necessary, saline or sympathomimetics are administered intravenously to increase blood pressure. To speed up the removal of the drug from the body, diuretics are taken.

Interaction with other drugs

First, we will present interactions with drugs that are typical for both Lozap and Lozap plus. And below we separately present interactions that are characteristic only of Lozap Plus.

Simultaneous use of Lozap plus with the following drugs can provoke arrhythmia, including death dangerous type"pirouette":

Class IA antiarrhythmic drugs (Quinidine, Hydroquinidine, Disopyramide, etc.);
Antiarrhythmic drugs class III(Amiodarone, Sotalol, Dofetilide, etc.);
Some antipsychotics (Thioridazine, Chlorpromazine, Levomepromazine, Trifluoperazine, Cyamemazine, Sulpiride, Sultopride, Amisulpride, Tiapride, Pimozide, Haloperidol, Droperidol);
Bepridil;
Cisapride;
Diphemanil;
Halofantine;
Mizolastine;
Pentamidine;
Terfenadine;
Vincamycin.

Lozap plus increases the concentration of calcium in the blood, so when used simultaneously with calcium supplements, the dosage of the latter should be adjusted.

Lozap plus in combination with Carbamazepine can provoke hyponatremia (decreased sodium concentration in the blood).

Iodine-containing contrast agents, used in combination with Lozap plus, against the background of dehydration, increase the risk of developing acute renal failure. Therefore, before using such contrast agents, the water-electrolyte balance and the amount of fluid in the tissues should be normalized.

Side effects

Lozap and Lozap plus may provoke the development of the following side effects: various organs and systems:

1. Blood system:

Anemia;
Thrombocytopenia (the level of platelets in the blood is below normal);
Eosinophilia (the number of eosinophils in the blood is higher than normal);
Henoch-Schönlein purpura.

2. The immune system:

Quincke's edema;
Photosensitivity.

3. Nervous system:

Anxiety;
Dizziness;
Drowsiness;
Sleep disturbance;
Migraine;
Paresthesia (feeling of goose bumps, numbness of the limbs);
Memory impairment;
Ataxia (disorder of movement coordination);
Peripheral neuropathy;
Hypesthesia (increased sensitivity to various irritants, for example, cold, touch, etc.);
Confusion;
Unusual dreams;
Sciatica (pain along the sciatic nerve).

4. Sense organs:

Taste disturbance (dysgeusia);
Visual impairment (decreased visual acuity or double vision);
Vertigo;
Blurred vision;
Burning sensation in the eyes.

5. The cardiovascular system:

Feeling of heartbeat;
Angina;
Fainting;
Arrhythmia;
Acute disorder cerebral circulation;
Hypotension (blood pressure drop below 90/60);
Orthostatic hypotension (a drop in blood pressure when moving to a standing position from sitting or lying down);
Nose bleed ;
Bradycardia (heart rate below 50 beats per minute);
Myocardial infarction;
Second degree atrioventricular block.

6. Respiratory system:

Nasal congestion;
Pharyngitis;
Laryngitis;
Dyspnea.

7. Digestive tract:

Diarrhea or constipation;
Vomit;
Dyspeptic symptoms (belching, bloating, flatulence, etc.);
Liver dysfunction;

8. Soft fabrics:

Myalgia (muscle pain);
Arthralgia (joint pain);
Rhabdomyolysis (muscle breakdown);
Muscle spasms;
Fibromylagia.

9. Genitourinary organs:

Impaired kidney function;
Kidney failure;
Decreased libido;
Urinary urgency;
Urinary tract infections;
Nocturia (more frequent urination at night than during the day).

10. Laboratory indicators:

Hyponatremia (low sodium levels in the blood);
Hypoglycemia (blood glucose levels below normal);
Increased activity of AST and ALT;
Increased concentrations of urea, creatinine and bilirubin in the blood plasma.

11. Other:

Lozap plus, in addition to the above, can provoke the following side effects:

Exacerbation of systemic lupus erythematosus;
Agranulocytosis (absence of neutrophils, basophils, eosinophils in the blood);
Leukopenia (the number of white blood cells in the blood is below normal);
Purpura;
Xanthopsia (visual impairment in which a person sees everything in yellow);
Respiratory distress syndrome;
Sialadenitis (inflammation of the salivary gland);
Cholestatic jaundice;
Toxic epidermal necrolysis;
Muscle cramps;
Glucosuria (glucose in the urine);
Interstitial nephritis;
Fever.

Contraindications for use

Lozap and Lozap plus are contraindicated for use

Individual hypersensitivity or allergic reactions on drug components;
Simultaneous administration with Aliskiren in the background diabetes mellitus, combined with renal failure with creatinine clearance less than 60 ml/min;
Renal failure with creatinine clearance below 30 ml/min;
Anuria (lack of urine);
Severe liver dysfunction;
Pregnancy and breastfeeding period;
Age under 18 years;
Uncorrectable hypokalemia, hyponatremia or hypercalcemia (only for Lozap plus);
Obstructive diseases of the biliary tract (only for Lozap plus);
Cholestasis (only for Lozap plus);
Gout or hyperuricemia (increased levels uric acid in the blood) with clinical symptoms (only for Lozap plus).

Lozap and Lozap plus should be used with caution if a person has the following conditions or diseases:

Arterial hypotension (low blood pressure);
Heart failure in combination with severe renal failure;
Severe chronic heart failure IV functional class according to NYHA classification;
Heart failure with arrhythmias;
Cerebrovascular diseases (cerebrovascular accidents, increased intracranial pressure, cerebral atherosclerosis, etc.);
Hyperkalemia (blood potassium levels higher than normal);
Age over 75 years;
Low circulating blood volume;
Violations of water and electrolyte balance;
Bilateral narrowing of both renal arteries;
Kidney or liver failure;
Previous kidney transplant;
Stenosis of the aortic and mitral valve;
Angioedema in the past;
Primary hyperaldosteronism;
Hypertrophic obstructive cardiomyopathy;
Diabetes mellitus (only for Lozap plus);
Hypochloremic alkalosis (for Lozap plus);
Hypomagnesemia (for Lozap plus);
Diseases connective tissue, for example systemic lupus erythematosus (for Lozap plus);
Bronchial asthma in the present or past (for Lozap plus);
Simultaneous use with NSAIDs, for example, Ibuprofen, Nimesulide, Nurofen, etc. (for Lozap plus);
Acute attack of myopia or angle-closure glaucoma (for Lozap plus).

Analogues of Lozap

Lozap and Lozap plus have two types of analogues on the pharmaceutical market of the CIS countries - these are synonyms and, in fact, analogues. Synonyms include drugs that contain exactly the same active substances, like Lozap and Lozap plus. Analogs include drugs that contain other active substances, but are as similar as possible. therapeutic effect with Lozap and Lozap plus. In principle, analogues of Lozapa are drugs belonging to the group of ACE inhibitors, and Lozapa plus - ACE inhibitors in combination with diuretics.

Synonyms Lozap and Lozap plus are reflected in the table.

*Synonyms Lozap*	*Synonyms Lozap plus*
Blocktran tablets	Blocktran GT tablets
Brozaar tablets	Vasotens N tablets
Vasotens tablets	Gizaar and Gizaar forte tablets
Zisacar tablets	Gisortan tablets
Cardomin-Sanovel tablets	Hydrochlorothiazide+Losartan-TAD tablets
Carzartan tablets	Cardomin plus-Sanovel tablets
Cozaar tablets	Losartan-N Richter tablets
Lakea tablets
Losarel tablets	Lakea N tablets
Losartan tablets	Losartan/Hydrochlorothiazide-Teva tablets
Losartan-Richter, Losartan-Teva, Losartan-TAD and Losartan McLeods tablets	Losarel Plus tablets
Lorista tablets	Presartan N tablets
Losakor tablets	Simartan-N tablets
Lotor tablets
Presartan tablets
Renicard tablets

Analogues of Lozap and Lozap plus are also reflected in the table.

*Analogues of Lozap*	*Analogues of Lozap plus*
Aprovel tablets	Atacand Plus tablets
Atacand tablets	Valz N tablets
Angiacand tablets	Valsacor N80, Valsacor N160, Valsacor N320 tablets
Artinova tablets	Valsacor ND160 tablets
Valz tablets	Vanatex Combi tablets
Valsafors tablets	Ibertan Plus tablets
Valsacor tablets	Cardosal Plus tablets
Valsartan capsules and tablets	Co-Diovan tablets
Valaar tablets	Coaprovel tablets
Hyposart tablets
Diovan tablets	Candecor ND 32 tablets
Ibertan tablets	Micardis Plus tablets
Irbesartan tablets	Ordiss N tablets
Irsar tablets	Teveten plus tablets
Candecor tablets	Edarbi Clo tablets
Cardosal 10, Cardosal 20 and Cardosal 40 tablets
Cardosten tablets
Kandesar tablets
Micardis tablets
Naviten tablets
Nortivan tablets
Ordiss tablets
Olimestra tablets
Prytor tablets
Tantordio tablets
Tareg tablets
Teveten tablets
Telmisartan Richter tablets
Firmasta tablets
Edarbi tablets

Russian analogs of Lozap

Synonyms and analogues Lozap and Lozap plus Russian production are reflected in the table.

	*For Lozap*	*For Lozap plus*
Synonyms	Blocktran tablets	Blocktran GT tablets
	Brozaar tablets	Lorista N, Lorista N 100 and Lorista ND tablets
	Losartan tablets
	Lorista tablets
	Valsafors tablets	Candecor N 8, Candecor N 16 and Candecor N 32 tablets
	Valaar tablets	Candecor ND 32 tablets
	Irsar tablets
	Candecor tablets
	Cardosten tablets
	Kandesar tablets
	Tareg tablets