Ascorbic acid with sugar instructions. Ascorbic acid (Vitamin C) with sugar

active substance: ascorbic acid;

1 tablet contains ascorbic acid (vitamin C) 25 mg;

Excipients: sugar, stearic acid, potato starch, glucose monohydrate, orange flavor.

Dosage form. Pills.

Basic physical and chemical properties: flat-cylindrical tablets with beveled edges, white.

Pharmacotherapeutic group. Simple drugs ascorbic acid (vitamin C). Ascorbic acid(vitamin C). ATX code A11G A01.

Pharmacological properties

Pharmacodynamics.

Ascorbic acid (vitamin C) has pronounced restorative properties. Belongs to the group of water-soluble vitamins. Takes part in redox reactions, regulation carbohydrate metabolism, affects the metabolism of aromatic amino acids, thyroxine metabolism, catecholamine biosynthesis, steroid hormones and insulin, is necessary for blood clotting, collagen and procollagen synthesis, connective and bone tissue. Improves capillary permeability. Promotes the absorption of iron in the intestines and takes part in the synthesis of hemoglobin. Increases nonspecific resistance body, has antidote properties. A deficiency of vitamin C in food leads to the development of hypo- and avitaminosis C, since this vitamin is not synthesized in the body.

Pharmacokinetics.

Absorption of ascorbic acid occurs predominantly in small intestine. The absorption process may be disrupted by intestinal dyskinesias, enteritis, achylia, helminthic infestation, giardiasis, as well as when consuming alkaline drinks, fresh fruit and vegetable juices. Maximum concentration medicine in blood plasma after oral administration is achieved within 4 hours. Easily penetrates into leukocytes, platelets, and then into all tissues; deposited in the posterior part of the pituitary gland, adrenal cortex, ocular epithelium, intermediate cells of the seminal glands, ovaries, liver, brain, spleen, pancreas, lungs, kidneys, intestinal wall, heart, muscles, thyroid gland. Metabolized mainly in the liver, into deoxyascorbic acid and subsequently into oxaloacetic and diketogulonic acids. Unchanged ascorbate and metabolites are excreted in urine, feces, and also pass into breast milk. When using high doses When plasma concentrations reach above 1.4 mg/dL, excretion increases sharply, and increased excretion may persist after discontinuation of use.

Clinical characteristics.

Indications

Prevention and treatment of vitamin C deficiency.

Ensuring the body's increased need for vitamin C during growth, pregnancy or lactation, during increased physical and mental stress, during infectious diseases and intoxications, hemorrhagic diathesis, V complex therapy bleeding (nasal, pulmonary, uterine), with radiation sickness, Addison's disease, overdose of anticoagulants, with damage to soft tissues and slow healing infected wounds, bone fractures.

Contraindications

Hypersensitivity to ascorbic acid or any of the excipients medicine. Thrombosis, tendency to thrombosis, thrombophlebitis, diabetes mellitus, serious illnesses kidney Urolithiasis - when using doses above 1 g per day. Fructose intolerance, glucose-galactose malabsorption syndrome.

Interaction with other drugs and other types of interactions.

Ascorbic acid at oral administration increases the absorption of penicillin, tetracycline, iron; promotes the absorption of aluminum in the intestine, which should be taken into account when simultaneous treatment antacids containing aluminum.

The simultaneous use of vitamin C and deferoxamine increases tissue toxicity of iron, especially in the heart muscle, which can lead to decompensation of the circulatory system. Vitamin C can only be used 2 hours after the deferoxamine injection.

Long-term use large doses in persons treated with disulfiramine, the disulfiram-alcohol reaction is inhibited.

High doses of the drug reduce the effectiveness of tricyclic antidepressants, neuroleptics - phenothiazine derivatives, tubular reabsorption of amphetamine, interfere with the excretion of mexiletine by the kidneys, and affect the resorption of vitamin B12.

Ascorbic acid increases total clearance ethyl alcohol.

The drug reduces the toxicity of sulfonamide drugs, reduces the effectiveness of heparin and indirect anticoagulants.

Vitamin C increases the excretion of oxalates in the urine, thus increasing the risk of formation of oxalate stones in the urine, and increases the risk of developing crystalluria during treatment with salicylates.

Quinoline drugs, calcium chloride, salicylates, corticosteroids for long-term use reduce ascorbic acid reserves in the body.

Absorption of ascorbic acid is reduced with simultaneous use of oral contraceptives, consumption of fruit or vegetable juices, and alkaline drinking.

Features of application

When using high doses or long-term use of the drug, it is necessary to monitor kidney function and levels blood pressure, as well as the functions of the pancreas. The drug should be used with caution in patients with a history of kidney disease.

For urolithiasis daily dose ascorbic acid should not exceed 1 g.

Large doses of the drug should not be prescribed to patients with increased blood clotting.

Because ascorbic acid increases iron absorption, its use in high doses may be harmful to patients with hemochromatosis, thalassemia, polycythemia, leukemia and sideroblastic anemia. Patients with high iron content in the body should use the drug in minimal doses.

Concomitant use of the drug with alkaline drinking reduces the absorption of ascorbic acid, so you should not drink it with alkaline mineral water. Also, the absorption of ascorbic acid may be impaired by intestinal dyskinesia, enteritis and achylia.

Use with caution to treat patients with glucose-6-phosphate dehydrogenase deficiency.

Ascorbic acid as a reducing agent can affect the results laboratory research, for example, when determining blood glucose, bilirubin, transaminase activity, lactate dehydrogenase.

Since ascorbic acid has a mild stimulating effect, it is not recommended to use the drug at the end of the day. Due to the stimulating effect of ascorbic acid on the formation of corticosteroid hormones, when using the drug in large doses, monitoring of kidney function and blood pressure is necessary.

Use during pregnancy or breastfeeding.

The drug can be used during pregnancy or breastfeeding in accordance with dosage recommendations and doctor's prescription. The recommended doses should be carefully observed and not exceeded.

The ability to influence the reaction rate when driving vehicles or other mechanisms.

Does not affect.

Directions for use and doses

Take the medicine orally, after meals.

Adults and children over 14 years old for the purpose of prevention should take 2-4 tablets (50-100 mg) per day, children from 3 to 14 years old - 2 tablets (50 mg) per day.

Treatment doses for children from 14 years of age and adults - 2-4 tablets (50-100 mg) 3-5 times a day, for children from 3 to 7 years - 2-4 tablets (50-100 mg) 2-3 times a day day, for children from 7 to 10 years old - 4 tablets (100 mg) 2-3 times a day, for children from 10 to 14 years old - 4-6 tablets (100-150 mg) 2-3 times a day.

Pregnant and postpartum women and those with low vitamin C levels breast milk You should take 12 tablets (300 mg) per day for 10-15 days, then for prevention - 4 tablets (100 mg) per day during the entire period of breastfeeding.

The duration of treatment depends on the nature and course of the disease and is determined by the doctor individually.

Children.

The drug is prescribed to children from 3 years of age.

Overdose

Ascorbic acid is well tolerated. It is a water-soluble vitamin and excess amounts are excreted in the urine.

Symptoms With long-term use of vitamin C in large doses, the function of the insular apparatus of the pancreas may be inhibited, which requires monitoring the condition of the latter. Overdose may lead to changes in the renal excretion of ascorbic acid and uric acid during acetylation of urine with the risk of precipitation of oxalate stones.

The use of large doses of the drug may lead to vomiting, nausea or diarrhea, which disappear after its discontinuation.

Treatment. Symptomatic therapy.

Adverse reactions

From the outside gastrointestinal tract: when used in a dosage of more than 1 g per day - irritation of the mucous membrane digestive tract, heartburn, nausea, vomiting, diarrhea.

From the kidneys and urinary system: damage to the glomerular apparatus of the kidneys, crystalluria, formation of urate, cystine and/or oxalate stones in the kidneys and urinary tract, kidney failure.

From the immune system: Quincke's edema, sometimes - anaphylactic shock in the presence of sensitization.

From the skin and subcutaneous tissue: skin rash, itching, urticaria, eczema.

From the endocrine system: damage to the insular apparatus of the pancreas (hyperglycemia, glycosuria) and disruption of glycogen synthesis up to the onset of diabetes mellitus.

From the outside of cardio-vascular system: arterial hypertension, myocardial dystrophy.

From the blood system and lymphatic system: thrombocytosis, hyperprothrombinemia, thrombus formation, erythrocytopenia, neutrophilic leukocytosis; in patients with blood cell glucose-6-phosphate dehydrogenase deficiency, it can cause hemolysis of red blood cells, hemolytic anemia(in patients with glucose-6-phosphate dehydrogenase deficiency).

From the outside nervous system: increased excitability, sleep disturbance, headache, feeling of heat, fatigue.

From the side of metabolism: disturbance of zinc and copper metabolism.

Best before date

Storage conditions

Store in original packaging at a temperature not higher than 25 ºС.

Keep out of the reach of children.

Package

10 tablets per label.

Manufacturer

JSC "KYIV VITAMIN PLANT".

Manufacturer location and the address of the place of its activities.

04073, Ukraine, Kiev, st. Kopylovskaya, 38.

Website: www.vitamin.com.ua.

Ascorbic acid with glucose tablets is medicinal product, which belongs to the vitamin group. It is intended to correct conditions caused by a significant lack of vitamin C.

A certain dosage can be used as a prophylactic against certain ailments during pregnancy. At diabetes mellitus the use of this remedy has clear restrictions.

Composition and release form

The product contains two active components:

• ascorbic acid (100 mg per tablet);
• glucose (870 mg per tablet).

Ascorbic acid is produced in tablet format. Even during pregnancy, sale in pharmacy chains possible without presenting a prescription from the attending physician.

Pharmacological effects on the body

Ascorbic acid (vitamin C), if the dosage is correct, immediately provides a whole range of health benefits. This is not only high-quality stimulation defensive reactions the body, but also normalizing metabolic processes.

Under the influence of this acid, the speed and productivity of some biological processes increases, for example, the quality of interferon production increases ( special substances that protect healthy cells from virus attack). This fact is especially relevant for diabetics during viral epidemics.

Without vitamin C, it is impossible to produce testosterone and estrogen.

The benefit of ascorbic acid is its ability to stimulate the formation of protein complexes - elastin and collagen. These substances are components connective tissue, which is necessarily present in almost all human organs. With age, the total number of such cells constantly decreases, which provokes the development of certain ailments.

Vitamin C is a catalyst for all biochemical reactions that are responsible for the absorption and excretion of iron in the diabetic body. Only if there is a sufficient amount of acid will benefit during pregnancy be obtained. Ascorbic acid and glucose help the processes of hematopoiesis and oxygen delivery to tissues and organs to proceed adequately.

In case of diabetes, vitamin C should be consumed with extreme caution!

The drug stimulates the formation of some important hormones. The instructions state that endocrine activity thyroid gland and adrenal glands will be determined precisely by the presence of ascorbic acid in the amount necessary for the body.

When should you use vitamin C?

The drug Ascorbic acid with glucose will be indicated for use in the following cases:

1. during pregnancy;
2. during lactation;
3. excessive need for vitamin C (during active growth);
4. under high physical and mental stress;
5. after suffering serious illnesses;
6. in the treatment of illnesses caused by stress.

Contraindications for use

The instructions provide information that there are absolute contraindications to use the drug:

• predisposition to thrombophlebitis;
• children under 6 years of age;
• excessive sensitivity to the drug.

There are also relative contraindications:

1. deficiency of the enzyme glucose-6-phosphate dehydrogenase;
2. sideroblastic anemia;
3. hemochromatosis;
4. thalassemia;
5. urolithiasis disease.

Description of the features of use of the drug

It is necessary to consume ascorbic acid strictly after meals.

The benefit from the drug will be obtained only in this case. The dosage depends entirely on the age of each individual patient, as well as on individual indications.

To prevent vitamin C deficiency, it should be consumed:

• adult patients – from 50 to 100 mg of the drug 1 time per day;
• during pregnancy – 100 mg once;
• adolescents from 14 to 18 years old - 75 mg 1 time per day;
• children from 6 to 14 years old - 50 mg 1 time per day.

The duration of the course is 14 days. During pregnancy, this period should be agreed upon with the attending physician, which should be adhered to.

For therapeutic purposes, the dosage will be as follows:

1. adult patients - from 50 to 100 mg of the drug 3-5 times a day;
2. during pregnancy – 100 mg 3-5 times a day;
3. adolescents from 14 to 18 years old – 50 – 100 mg 3-5 times a day;
4. children from 6 to 14 years old – 50 – 100 mg 3 times a day.

IN medicinal purposes the vitamin must be used based on the doctor’s recommendation. The doctor will prescribe a dosage depending on the course of the disease and the results of laboratory tests. This is especially true during pregnancy.

Special instructions for diabetics

For those who suffer from diabetes, there are special recommendations by application. The instructions state that the drug must be used under strict medical supervision. Please note that 1 tablet of the drug contains 0.08 grain units(HE).

When taking vitamin C, a diabetic must adjust the amount of carbohydrates consumed. Otherwise, the benefit of the drug will be questionable.

Cases of overdose

If an unintentional overdose occurs, the following symptoms may occur:

• headache;
• excessive nervous excitability;
• gagging;
• attacks of nausea;
• manifestations of gastritis;
• damage to the pancreas.

If these symptoms occur, you should stop using the drug and perform symptomatic therapy. There is no specific antidote.

Negative consequences

Adverse reactions when consuming the vitamin are extremely rare. As a rule, acid is well tolerated by patients. Sometimes the following negative consequences may occur:

1. allergic reactions;
2. damage to the mucous membrane of the stomach and duodenum;
3. hemogram changes;
4. damage to the insular apparatus.

In pharmacology, there is an analogue of the drug Ascorbic acid and glucose - this is a combination of vitamin C and dextrose.

Vitamins and vitamin-like products

Indications

Hypovitaminosis C, hemorrhagic diathesis, capillary toxicosis, hemorrhagic stroke, bleeding (including nasal, pulmonary, uterine), infectious diseases, idiopathic methemoglobinemia, intoxication, incl. chronic intoxication with iron drugs, alcoholic and infectious delirium, acute radiation sickness, post-transfusion complications, liver diseases (Botkin's disease, chronic hepatitis and cirrhosis), gastrointestinal diseases (achilia, peptic ulcer, especially after bleeding, enteritis, colitis), helminthiasis, cholecystitis, adrenal insufficiency (Addison's disease), sluggishly healing wounds, ulcers, burns, bone fractures, dystrophy, physical and mental overload, the period of convalescence after past diseases, pregnancy (especially multiple pregnancy, against the background of nicotine or drug addiction), lactation, hemosiderosis, melasma, erythroderma, psoriasis, chronic common dermatoses. In laboratory practice - for marking red blood cells (together with sodium chromate 51Cr).

Vaginal tablets - chronic or recurrent vaginitis caused by anaerobic flora (due to altered vaginal pH); normalization of disturbed vaginal microflora.

Contraindications

Hypersensitivity, thrombophlebitis, tendency to thrombosis, vulvovaginal candidiasis (for vaginal tablets).

Use during pregnancy and breastfeeding

Minimum daily need in ascorbic acid in the II-III trimesters of pregnancy - about 60 mg. It should be borne in mind that the fetus can adapt to high doses of ascorbic acid taken by a pregnant woman, and then the newborn is likely to develop a withdrawal syndrome. It has been reported that treatment with high doses of vitamin C taken during pregnancy is associated with a risk of developing scurvy in newborns, and with intravenous administration in high doses, there is a risk of miscarriage due to estrogenemia ( non-teratogenic effects).

The minimum daily requirement during lactation is 80 mg. A maternal diet containing adequate amounts of ascorbic acid is sufficient to prevent deficiency in infant. Theoretically, there is a danger to the baby when the mother uses high doses of ascorbic acid (a nursing mother is advised not to exceed daily requirement in ascorbic acid). For injection forms. Animal reproduction studies using ascorbic acid injections have not been conducted. It is not known whether vitamin C, when administered by injection to pregnant women, can cause embryotoxic effects or impair reproductive potential. Injectable forms can be prescribed during pregnancy only if absolutely necessary. FDA category of effect on the fetus - C(for injection forms).

Side effects

From the cardiovascular system and blood (hematopoiesis, hemostasis): thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis.

From the nervous system and sensory organs: with too rapid intravenous administration - dizziness, weakness. From the gastrointestinal tract: when taken orally - irritation of the gastrointestinal mucosa (nausea, vomiting, diarrhea), diarrhea (when taking doses of more than 1 g / day), damage to tooth enamel (with intensive use of chewable tablets or resorption of oral forms). From the side of metabolism: metabolic disorders, inhibition of glycogen synthesis, excessive formation of corticosteroids, sodium and water retention, hypokalemia. From the outside genitourinary system: increased diuresis, damage to the glomerular apparatus of the kidneys, formation of oxalate urinary stones(especially when long-term use in doses of more than 1 g/day). Allergic reactions: skin rash, skin hyperemia. Others: pain at the injection site (with intramuscular injection). For vaginal tablets: local reactions- burning or itching in the vagina, increased mucous discharge, hyperemia, swelling of the vulva.

Precautionary measures

When prescribing IV solutions, you should avoid administering them too quickly. During long-term treatment Monitoring of renal function, blood pressure and glucose levels is necessary (especially when prescribing high doses). Prescribe with extreme caution high dosages patients with urolithiasis, diabetes mellitus, a tendency to thrombosis, receiving anticoagulant therapy, and being on a salt-free diet.

Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood glucose, bilirubin, transaminase activity, LDH, glucose in urine, including causing false-negative results of stool tests for occult blood). When used in the form vaginal tablets ascorbic acid does not inhibit the growth of fungal flora of the vagina. Manifestations such as burning and itching may be due to the presence of a concomitant asymptomatic fungal infection, so if these symptoms occur, an analysis should be performed to exclude a fungal infection. Breaks in the use of vaginal tablets due to intercyclic or menstrual bleeding are not necessary.

Storage conditions of the drug

In a dry place, protected from light.

Keep out of the reach of children.

Kyiv VITAMIN PLANT

Active substance

Ascorbic acid+Sugar

Release form

oral lozenges 25 mg with blueberry, currant, lemon flavors, 10 rolled tablets

Who is Ascorbic Acid with Sugar Indicated for?

Ascorbic acid preparations are used for preventive and therapeutic purposes:
prevention colds, flu; for infectious diseases with elevated temperature and intoxication; infectious diseases and convalescence period; increased need for vitamin C during pregnancy and lactation; in older people with insufficient and monotonous diet; for slowly healing wounds, bone fractures, ulcers; with enhanced physical activity and mental stress, overwork, overexertion, fatigue, weakness, asthenia, muscle fatigue; prevention and treatment of scurvy, vitamin C hypovitaminosis; if an additional source of vitamin C is needed during periods of insufficient intake from food or the body’s increased need for vitamin C; tendency to bleeding, especially gums, with hemorrhagic diathesis, nasal, pulmonary, hepatic bleeding; supplement for iron therapy; diseases of the gastrointestinal tract (achilia, peptic ulcer, especially after bleeding, enteritis, colitis, helminthiasis, cholecystitis); liver diseases (Botkin's disease, chronic hepatitis and cirrhosis); adrenal insufficiency (Addison's disease); to increase acidity in urine (lower pH); hemosiderosis; melasma, erythroderma, psoriasis, chronic common dermatoses; as an antioxidant - atherosclerosis, bronchial asthma, diffuse diseases connective tissue ( rheumatoid arthritis, systemic lupus erythematosus, scleroderma), etc.; alcoholic and infectious delirium; acute radiation sickness; post-transfusion complications; overdose of anticoagulants, poisoning with aconite, anesthesin, aniline, antabuse, barbiturates, benzene, dichloroethane, potassium permanganate, methyl alcohol, arsenic, carbon monoxide, hydrocyanic acid, sulfonamides, thallium, phenols, quinine.

How to use Ascorbic acid with sugar

Inside, after eating.
For medicinal purposes, unless otherwise prescribed by a doctor, ascorbic acid is prescribed 500 - 1000 mg/day in two doses (for children over a year old- 250 - 500 mg/day). The maximum recommended dose is 3000 mg per day in three divided doses. The drug is taken for 3 - 5 days. If you take the drug for a longer period of time, you should consult your doctor.
IN for preventive purposes(in the winter-spring period and with malnutrition) - 50 - 100 mg/day (for children - 25 mg/day).
During pregnancy and breastfeeding - 300 mg/day for 10 - 15 days, then 100 mg/day.
Chewable tablets It is necessary to chew or keep in the mouth until completely absorbed, preferably immediately after eating with liquid.

Side effects of Ascorbic acid with sugar

Very rare.
After long-term use of large doses (4 - 2 g per day), diarrhea (irritation of the gastrointestinal mucosa, nausea, vomiting, diarrhea), urate oxalate kidney stones, hyperoxalaturia, chemical cystitis, and a temporary decrease in urine pH may occur.
With long-term use in large doses, depression of the function of the insular apparatus of the pancreas, as well as depression of kidney function, is possible.

For whom is Ascorbic acid with sugar contraindicated?

The drug is contraindicated in diabetes mellitus, patients with increased blood clotting, thrombophlebitis and a tendency to thrombosis, hypersensitivity.
Can be used during pregnancy, taking into account general contraindications.

Interaction of ascorbic acid with sugar

Drug interactions are more likely to occur with long-term, high-dose use.
Increases blood concentrations of salicylates (increases the risk of crystalluria), ethinyl estradiol, benzylpenicillin and tetracyclines.
With estrogens - the level of the hormone in the blood serum increases.
With oral cotraceptives containing estrogens, the contraceptive effect is reduced.
Reduces the anticoagulant effect of coumarin derivatives.
Improves the absorption of iron preparations in the intestines.
Increases the total Cl of ethyl alcohol.
Quinoline drugs, calcium chloride, salicylates, and corticosteroids deplete vitamin C reserves when used for a long time.

Overdose of Ascorbic acid with sugar

An overdose can lead to the development of vitamin C hypervitaminosis.