Reviews of the drug nystatin for thrush. Correct intake of Nystatin tablets: treating thrush

Nystatin - "old" antifungal antibiotic, representing a group of polyenes (so-called natural antibiotics) on pharmacy shelves. The drug has a very narrow specialization, showing its antimycotic activity against only yeast-like fungi of the genus Candida. This happens as follows: nystatin interacts with sterols that are part of the cell membranes of fungi. As a result, the permeability cell membranes, which entails the release of "freedom" of the main components of the fungal cell. The action of nystatin is characterized as fungistatic, i.e. inhibiting the growth and reproduction of fungi. After removing the fungistatic agent, their growth has every chance of resuming.

Nystatin is available in four forms at once dosage forms: These are tablets, ointment, rectal and vaginal suppositories. When taking the drug orally, it is poorly absorbed from gastrointestinal tract. Local application of nystatin avoids its absorption into the systemic circulation. The drug does not accumulate in the body and is excreted in feces. Indications for the use of the drug will vary depending on the form of release. So, vaginal and rectal suppositories are used according to the injection site, that is, in the first case it will be vaginal candidiasis, and in the second - candidiasis lower sections intestines. Tablets are used for candidiasis of the skin and mucous membranes, as well as internal organs, ointment - only skin and mucous membranes. IN for preventive purposes You can use nystatin in all forms of release. It should be noted that at present, this drug, in the language of Internet memes, is “no longer a cake” and is gradually losing ground in relation to a number of diseases.

So, for decades, nystatin was practically the only drug for the treatment of oral candidiasis. However, previously collected information about 90% effectiveness this drug V modern realities do not find their confirmation, and in clinical practice fluconazole has proven to be much more successful in the treatment of this disease.

When internal organs are affected by candida, nystatin is prescribed orally, regardless of diet. Adults should take 500,000 units 4-8 times a day. For generalized candidiasis (when the fungal infection acquires impressive proportions) daily dose nystatin can reach up to 6,000,000 units. The doses of the drug used in pediatric practice depend on the age of the child: 250,000 units 3-4 times a day (from 1 to 3 years), 250,000-500,000 units 4 times a day (over 3 years). The duration of treatment is on average 10-14 days with the possibility of repeating the drug course after a week's "rest" from antimycotic therapy. The ointment should be applied to the areas of skin and mucous membranes affected by candida in a thin layer 2 times a day for 7-10 days. A combination of ointment and nystatin tablets is allowed. Before insertion into the vagina vaginal suppositories, the necessary hygiene procedures. Dosage regimen: 1 suppository twice a day, morning and evening. The course of treatment is 10-14 days. Frequency and dosing regimen rectal suppositories It is similar, only the route of administration into the body is different.

Pharmacology

Antifungal agent, antibiotic of the polyene group. By binding to sterols in the cell membrane of fungi, it disrupts its permeability, which leads to the release of the main components of the cell. Active against Candida albicans.

Pharmacokinetics

After oral administration, it is poorly absorbed from the gastrointestinal tract. It is excreted almost completely in the feces unchanged. Does not accumulate.

When external and local application not absorbed through the skin or mucous membranes.

Release form

10 pieces. - contour cell packaging (2) - cardboard packs.

Dosage

Inside adults - 500,000-1,000,000 IU 3-4 times / day, children - 100,000 4 times / day. The duration of treatment averages 14 days.

Outwardly, intravaginally and rectally apply 2 times / day in the morning and evening.

Interaction

With simultaneous use of nystatin with clotrimazole, the activity of the latter decreases.

Side effects

From the outside digestive system: nausea, vomiting, diarrhea.

Allergic reactions: skin rash, urticaria.

Local reactions: irritation.

There may be a risk of the spread of resistant forms of fungi, which requires discontinuation of nystatin.

Indications

Candidiasis of the skin, mucous membranes, oral cavity and pharynx, vagina and internal organs (gastrointestinal tract, lungs, kidneys). Prevention of fungal complications of antimicrobial therapy.

Contraindications

Liver failure, pancreatitis, gastric ulcer and duodenum, increased sensitivity to nystatin.

Features of application

Use during pregnancy and breastfeeding

Although nystatin is absorbed in small amounts, it is not known whether it is excreted from breast milk Therefore, if it is necessary to use it during lactation, the issue of stopping breastfeeding should be decided.

Use for liver dysfunction

Contraindicated in liver failure.

special instructions

If local irritation or an allergic reaction develops, nystatin should be discontinued.

During menstruation, treatment should not be interrupted.

Nystatin is a medicinal antifungal drug that has a fungistatic effect. Available in the form of tablets (250,000 and 500,000 units), vaginal and rectal suppositories, ointments.

Pharmacological action of Nystatin

According to the instructions, the active ingredient of the drug is nystatin.

Excipients of the tablets are emulsion KE-10, pigment titanium dioxide, vanillin, Tween 80, methylcellulose, stearin, medical talc, stearic acid, milk sugar, potato starch.

An auxiliary component of Nystatin suppositories is a fat base. The ointment contains the following Excipients, such as medical petroleum jelly and anhydrous lanolin.

According to the instructions, Nystatin is a polyene group antibiotic produced by the actinomycete Streptomyces noursei.

The components of the drug bind to stearins in the cell membranes of fungi, which leads to their inability to function as a selective barrier, and this causes the loss of their main cellular components.

The action of Nystatin is aimed at defeating pathogens of mold mycoses, sporotrichosis, chromomycosis, blastomycosis (deep and visceral), and dermatomycosis. The drug is effective against some pathogenic protozoa.

When used, Nystatin affects the yeast-like fungi Candida and Aspergillus. The medicine blunts the development of vegetative forms of dysenteric amoebae in the intestines.

Marked high efficiency Nystatin for thrush.

In accordance with the instructions, Nystatin in all forms of release is not active against viruses, actinomycetes and bacteria.

With local and external use, the drug is not absorbed through the mucous membranes and skin. When administered internally, Nystatin is poorly absorbed from the gastrointestinal tract. It is excreted unchanged from the body along with feces.

Indications for use of Nystatin

Nystatin is prescribed for the prevention and treatment of fungal diseases of internal organs, mucous membranes, skin, gastrointestinal tract, which are caused by yeast-like fungi of the genus Candida. These include candidiasis of the skin, mucous membranes and internal organs, candidiasis oral cavity and vagina.

Nystatin is prescribed for thrush, as well as to prevent the development of candidiasis while taking high doses antibiotics (especially tetracyclines) to young children, debilitated patients and the elderly.

Methods of using Nystatin and dosage

For adults, Nystatin tablets should be taken 500,000 IU 3-4 times a day or 250,000 6-8 times a day, for the treatment of severe candidiasis of internal organs and candidiasis - 500,000 IU 6-8 times a day. For children, the dosage of Nystatin in tablets depends on the age of the child: up to 1 year, ¼ tablets of 250,000 IU are prescribed, 1-3 years - 1 tab. 250,000 units, from 3 years – 250,000-400,000 units. The frequency of taking tablets for children is 3 times a day.

Nystatin ointment for mycoses of the mucous membranes, skin dermatitis and fungal complications that have arisen when taking antibiotics, is applied to the affected surfaces 2 times a day until the symptoms of the disease disappear completely.

For thrush, Nystatin is prescribed in the form of suppositories. Candles Nystatin is also recommended for the treatment of lower intestinal candidiasis, vulvovaginitis and colpitis. Rectally, 1 suppository is injected deep into the rectum 1-2 times a day. Use 1 Nystatin suppository intravaginally 2 times a day.

The duration of the course of use of Nystatin is 10-14 days.

Effective combination local treatment with Nystatin taken orally.

Side effects of Nystatin

Nystatin in all forms of release can cause the development adverse reactions in the form of an allergy accompanied by rashes, skin itching, skin hyperemia, urticaria.

When using Nystatin suppositories, vaginal irritation is possible; when taking Nystatin tablets, a bitter taste in the mouth, nausea, abdominal pain, vomiting, and diarrhea may occur.

Contraindications to the use of Nystatin

The medicine is not prescribed to patients with hypersensitivity to its components, liver dysfunction, peptic ulcers of the stomach and duodenum, or pancreatitis.

According to the instructions for Nystatin, the drug can be used during pregnancy and lactation.

Overdose

According to reviews, overdose may increase side effects.

Additional Information

During Nystatin therapy for thrush, you should abstain from sexual intercourse. Also recommended joint treatment both sexual partners.

In accordance with the instructions, Nystatin should be stored in a cool, dark place out of reach of children.

Nystatin is available from pharmacies with a doctor's prescription.

Shelf life – 24 months.

Thrush is very unpleasant disease. Treatment of thrush with nystatin is very effective at any stage of the disease. Nystatin is available in three types, these are tablets, suppositories, and nystatin ointment. As a group, these drugs are very effective in treating thrush in both women and men.

Thrush - description and symptoms of the disease

Thrush is a disease caused by fungi of the genus Candida.

In women, thrush manifests itself in the form of yeast-like vaginal discharge, an unpleasant odor and itching in the outer part of the vagina. Also, quite often, thrush in women can affect the mucous membrane of the nose, pharynx and oral cavity.

Men do not have thrush obvious signs diseases. There is no discharge in men, but bad smell On the head of the penis, thrush in men is quite capable of triggering.

Also, Candida fungi, or in other words thrush, affect the mucous membrane of the nasopharynx and so on in children and young children, even infants may have oral thrush.

Treatment of thrush with nystatin in women

Treatment of thrush should generally be carried out under the supervision of a doctor, this is the very first and important rule. Practice shows very good results in the treatment of thrush in women with nystatin. A lot of positive feedback You can hear about curing thrush in women with the inexpensive and effective antifungal drug nystatin. Treatment of thrush in women with nystatin can be: indoor application nystatin in the form of tablets (oral treatment of thrush with nystatin), suppositories or tampons of nystatin ointment vaginally. You can treat thrush in girls and women externally - this is the use of nystatin ointment.

Treatment of thrush in women - nystatin tablets

Nystatin tablets are very helpful in treating thrush in the weaker half of humanity. Before starting treatment with nystatin tablets, you must consult a doctor!!! You need to pay attention to this!!! Nystatin tablets are used mainly in the treatment of advanced or chronic form thrush in women. Nystatin tablets are an antibiotic antifungal action. It is very poorly absorbed into the blood and almost all of it is excreted in feces and urine.

Nystatin tablets for the treatment of thrush should be recommended by a specialist based on the results of tests and smears. He must also prescribe the dosage of the drug. If we take information from official instructions nystatin in tablets, then the treatment of thrush is carried out as follows: take the tablets orally without chewing, washing down with a sufficient amount of water 3-4 times a day.

Treatment of thrush in women vaginally it is also possible with the drug nystatin tablets in vaginal use- insert the tablet deeply into the vagina 2 times a day for 7-10 days.

Vaginal and orally usually combined with the use of nystatin ointment, applying it externally, applying the required amount of nystatin ointment to the affected areas of the skin or genitals, twice a day for 7-10 days.

Treatment of thrush with nystatin in men

Treatment of thrush in men with nystatin is carried out mainly with nystatin ointment. The ointment must be applied to the head of the penis twice a day for seven to ten days.

Treatment is very common combined method- This is treatment with nystatin ointment and nystatin in tablet form. Take tablets 2-4 times a day. This is the most effective method treatment of thrush in men.

Treatment with nystatin for thrush - general rules

• You should not take alcohol or drinks containing alcohol together with nystatin.
• Treatment with nystatin suppositories is contraindicated during menstruation
• During treatment, it is necessary to refrain from excessive intake of very salty and spicy foods.

Treatment is usually repeated after the first course of treatment. This occurs no earlier than 2 weeks after completing the first course. We recommend that you persistently carry out treatment under the supervision of a specialist doctor.

Fungal diseases must be treated at the first appearance of symptoms, otherwise damage to all organs and tissues of the body may occur.. One of the most popular and effective means against fungi - Nystatin. You should consider what kind of drug it is and for what diseases it is prescribed.

Description of the medicine

Despite the fact that Nystatin is intended for the treatment of fungal diseases, it is not considered an antimycotic agent, but its pharmacological group– polyene antibiotics. This highly targeted medicine natural origin, with high sensitivity to yeast-like and mold fungi.

Release forms:

When Nystatin molecules come into contact with fungi, they quickly penetrate the cell membrane. Having reached the required concentration, the drug forms pores in the membrane of the fungi, which leads to suppression of growth and slowdown of their activity. Fungal cells lose electrolytes, an excess supply of salts and liquid occurs, and ultimately the death of microorganisms occurs. Even a small amount of Nystatin in the body reduces the intensity of fungal proliferation, and when high concentration completely destroys them.

Nystatin almost does not react with other drugs, this is explained by its low absorption. When taken orally, the medicine is practically not absorbed into the gastrointestinal tract. But, if Nystatin is used simultaneously with other drugs, you should know how the drugs can affect each other (Table 1)

Table 1 - Use of Nystatin in combination with other drugs

Important! It is necessary to warn your doctor about taking any medications if you are prescribed to take Nystatin.

This is especially true for internal reception. External remedies with this active substance are practically not absorbed into the blood and cannot affect the action of other drugs.

Indications and contraindications

The main indication for Nystatin is the treatment of diseases that develop as a result of active proliferation of fungi. Depending on the location of the infection, the doctor prescribes the most suitable form drug.

It is important to know when choosing Nystatin why this drug is used in tablets:

Vaginal Nystatin suppositories are used for:

1. Therapy of candidiasis, vulvovaginitis and colpitis of fungal origin.
2. Prevention of infections caused by fungi with local antibacterial therapy.
3. Preventing candidiasis after surgery.

Dosage form for rectal use:

1. At fungal infection anus and colon.
2. Before and after proctological operations.
3. To prevent the proliferation of fungus in the presence of hemorrhoids, fissures, anal fistulas.

For Nystatin ointment, the indications are as follows:

1. In case of defeat skin fungi.
2. Fungal infections of the genital organs.
3. Stomatitis and thrush in the oral cavity.
4. For extensive diaper rash to prevent fungal infection.
5. Treatment of fungus on the nail plates.

Many people believe that the drug Nystatin is used only in gynecology, but this is not so. It is widely used in urology: for the treatment of fungal prostatitis, cystitis and urethritis. In this case, both tablets are prescribed for oral administration and an ointment for application to the mucous membrane of the genital organs. For kidney inflammation of fungal origin, a course of Nystatin tablets is required. In addition, when long-term treatment diseases urinary system Antibiotics must be taken to prevent the development of fungal inflammation.

In surgery, this remedy is used to avoid fungal infections in postoperative period. Nystatin is prescribed for elevated roseola and severe infections to prevent infection of weakened patients with fungi.

Important! Nystatin is strictly contraindicated when carrying a child at any stage and during lactation.

If it is not possible to replace the drug with another, then stop breastfeeding for the duration of treatment. Another 4 months before the planned conception of a child, it is necessary to stop taking Nystatin, especially for men, as it can affect the quality of sperm.

The drug is contraindicated in case of liver dysfunction, peptic ulcers stomach and intestines, pancreatitis. It is not prescribed if cases have been recorded allergic reactions on the constituent components of the drug.

Treatment regimens

Treatment with Nystatin cannot take place without a doctor's prescription. Only a specialist will be able to assess the patient’s condition, take tests to identify the causative agent of the infection and select the correct dose of the drug.

If treatment of diseases of the genital organs is carried out, then both partners should use the drug, even if signs of inflammation are present in only one of them.

Treatment of genital candidiasis:

At skin diseases that occur without damage to internal organs, it is enough to lubricate the affected areas twice a day. The course of therapy is at least 10 days.

The use of tablets is indicated for internal lesions. How to take Nystatin:

1. Adults one tablet (250 thousand units) up to eight times a day.
2. Adults one tablet (500 thousand units) three times a day.
3. Children from 12 months to 3 years of age are prescribed one tablet (250 thousand units) three times a day.
4. From 3 years of age the dosage increases: one tablet (250 thousand units) four times a day.

For severe lesions, the dose can be doubled, but only as directed by a doctor. The duration of therapy is 7-10 days, the course is repeated if necessary. For children under one year old, only a doctor can select the dosage based on the child’s condition, his weight and the presence of concomitant diseases.

For cystitis, prostatitis and urethritis, nystatin is taken not only orally, but also ointment is applied to the mucous membranes of the genital organs and the opening of the urethra to improve the effect of treatment and prevent re-infection.

For diseases of the oral mucosa, use ointment or wipe the affected areas with a solution of water and Nystatin tablets. Adults can hold the tablet in their mouth until it dissolves.

Nystatin is a low-toxic drug, therefore side effects do not occur often. What the patient may feel:

If side effects occur while taking Nystatin, you should consult your doctor to find another one. antifungal agent with another active ingredient in the composition. However, if you follow the doctor’s recommendations, the drug in most cases is able to completely neutralize the effect of pathological microorganisms.

Thrush is an unpleasant disease that is quite common. Even an infant can get candidiasis. The disease caused by the Candida fungus is quite easy to treat if it is started in a timely manner. Often, for candidiasis, doctors prescribe the drug Nystatin.

Principle of action and release form of Nystatin

Nystatin – medicinal product, belonging to the group of polyenes. This tool is a great assistant in the fight against yeast fungi, including bacteria of the genus Candida. The principle of action of the drug is to create a kind of film trap for the fungus. Without the opportunity to receive food and reproduce, the thrush pathogen quickly dies. And then leaves the body along with fecal matter.

On this moment There are several forms of release of Nystatin:

• Suppositories for the treatment of vaginal candidiasis;
• Suppositories used rectally;
• Pills;
• Cream (ointment).

Each form of the drug is intended for the treatment of candidiasis in different affected areas. What form of medication to use is prescribed by the doctor. There is another form of the drug that is used if a baby gets candidiasis - drops.

How effective is Nystatin?

The effectiveness of Nystatin can be judged by how it affects thrush. After starting treatment with it, symptoms of the disease such as itching, burning, discharge from vaginal and rectal candidiasis, disappear after 2 - 3 days. This suggests that the product actively affects the fungus and quickly removes it from the body. Another important quality of the drug is its release form. Thanks to in various ways Using Nystatin, you can cure thrush in any area of ​​the body. Often, a drug is prescribed not only to treat existing thrush, but also to prevent its occurrence, for example, during long-term treatment with antibiotics. It is also prescribed for the treatment of thrush in newborns.

How is thrush treated with Nystatin?

Treatment of thrush with Nystatin can occur in two ways:

1. Systemic;
2. Local.

This largely depends on the type of candidiasis, as well as on the gender of the patient. It is not recommended to use the drug without a doctor's prescription. Usually, if one partner is affected by candidiasis of the genital organs, the second is also prescribed a course preventive treatment. IN this period It is recommended to refrain from unprotected sex.

Nystatin tablets for thrush

The tablets can be taken by both men and women. They are prescribed for the treatment of all types of candidiasis. The protective layer of the tablet is yellowish in color. The full course of treatment is prescribed by the attending physician. It is usually necessary to drink Nystatin tablets for 7-10 days to completely destroy the active fungus.

It is important to note that you cannot stop taking the drug on your own. Even if the symptoms of thrush are absent 2 days after the start of treatment, you need to drink the entire course. may be prescribed by a doctor as preventative measure. If fungal infection in the mouth or larynx, then it is worth putting the tablet on the cheek or under the tongue and wait for it to dissolve completely.

Nystatin suppositories for thrush

For rectal and vaginal candidiasis, the drug is prescribed in the form of suppositories. Candles with nystatin are mainly prescribed for women from genital thrush. Before starting a course of treatment, a girl should consult a doctor and undergo a complete examination.

The full course of drug administration is usually two weeks. But the symptoms of thrush can disappear within a few days after the start of using suppositories.

It should also be remembered that it is best to perform the procedure in the evening, before that you need to take a shower. If you don't follow the rules intimate hygiene, then the colon and vagina are at risk of infection. The candle is inserted in a lying position. After this, it is not recommended to get up for 3 - 4 hours.

Ointment (cream) Nystatin for thrush

Nystatin ointment for thrush is prescribed quite often. It helps to cope with local foci of infection. In this case, it is recommended to use the ointment in conjunction with other forms of release of the drug. This way the treatment effect is enhanced by the medicine. It is prescribed most often, but can also be used by women.

How to use Nystatin ointment

Instructions for using the ointment are quite simple. It should be applied 2 times a day to the areas affected by the fungus in a thin, even layer. The attending doctor decides how many days to carry out the course. On average, for recovery it is necessary to apply the product for 7-10 days. It is also recommended to use complex treatment with ointment and tablets or suppositories at the same time. The ointment should be kept in a cool place to maintain its properties.

Nystatin for thrush during pregnancy

Can the drug be used during pregnancy? Since Nystatin is not absorbed into the blood, there is no point in talking about its harm to the unborn fetus. Therefore, it can be used during pregnancy.

How to take and what form of the product to use? Many doctors recommend choosing treatment with ointment if it appears. It is safer than suppositories and tablets. But does treatment with nystatin ointment help with thrush in pregnant women? The drug in this form of release is without complex treatment may have little effect on Candida fungus.

Despite all positive properties Nystatin, it should absolutely not be used during pregnancy. early stages. This is due to the effect of the drug on the mucous membrane, especially with vaginal candidiasis.

Nystatin for the prevention of thrush

The use of the drug for prophylaxis is quite common in the treatment of other diseases with antibiotics. The dosage is prescribed in individual cases.

Interactions with other drugs

Nystatin for thrush, together with taking Tetracycline, enhances its effectiveness. This has a stronger effect on microbes and fungi.

But there are medicines, not recommended for use with Nystatin for thrush

• Anticoagulants;
• Bactericidal antibiotics;
• Contraceptives.

Contraindications and side effects

The use of the drug has its contraindications. It cannot be used for treatment of the genitals and other areas if the patient has diseases of the gastrointestinal tract, as well as disorders of the liver. Contraindication is also intolerance to the components.

Side effects may include the following symptoms, which will disappear immediately after stopping Nystatin:

• loss of appetite;
• nausea, vomiting;
• allergic reaction;
• diarrhea.

Frequently asked questions and answers

Can I buy Nystatin without a prescription?

You can buy the product at the pharmacy without a prescription. But self-medication without consulting a doctor is not recommended.

Can you drink alcohol while taking Nystatin?

The drug does not interact with alcohol. But this does not mean that they can be combined. This is due to the fact that to treat candidiasis it is necessary to follow a diet in which alcohol is completely excluded.

Don't you get better from Nystatin?

Since the drug is not hormonal agent, then from its reception excess weight doesn't appear.

Delay 8 days. Can Nystatin suppositories have this effect?

The use of Nystatin for thrush in women is extremely in rare cases affects disruption of the menstrual cycle. In this case, the delay may be caused inflammatory processes which can occur due to thrush in women.

Is it possible to use Nystatin suppositories during menstrual cycle Or is it better to switch to tablets?

During menstruation, the use of suppositories will be ineffective, since their components will quickly be removed from the vagina along with blood clots. But you should not interrupt the course. If the doctor prescribed suppositories, then it is necessary to continue to administer the drug.