Home Analyzes Concor: instructions for use. Concor is a leading β-blocker of the second generation

Concor: instructions for use. Concor is a leading β-blocker of the second generation

Published on this page detailed instructions by application Concora. The available dosage forms of the drug (tablets 5 mg and 10 mg), as well as its analogues, are listed. Information is provided on the side effects that Concor may cause and on interactions with other medications. In addition to information about diseases for the treatment and prevention of which they are prescribed medicine(coronary artery disease, heart failure, decreased blood pressure), the administration algorithms, possible dosages for adults and children are described in detail, the possibility of use during pregnancy and breastfeeding is clarified. The abstract for Concor is supplemented with reviews from patients and doctors.

Instructions for use and dosage

The drug is taken orally 1 time per day. The tablets should be taken with a small amount of liquid in the morning before, during or after breakfast. The tablets should not be chewed or crushed into powder.

Arterial hypertension and angina pectoris

The dose is selected individually, primarily taking into account the heart rate and the patient’s condition.

As a rule, the initial dose is 5 mg 1 time per day. If necessary, the dose can be increased to 10 mg 1 time per day. During treatment arterial hypertension and angina pectoris, the maximum recommended dose is 20 mg once a day.

Chronic heart failure

The standard treatment regimen for chronic heart failure includes the use of ACE inhibitors or angiotensin 2 receptor antagonists (in case of intolerance to ACE inhibitors), beta-blockers, diuretics and, optionally, cardiac glycosides. At the beginning of treatment of chronic heart failure with Concor, a special titration phase is required under regular medical supervision.

The precondition for treatment with Concor is stable chronic heart failure without signs of exacerbation.

Treatment with Concor begins in accordance with the following titration scheme. Individual adaptation may be required depending on how well the patient tolerates the prescribed dose, i.e. the dose can only be increased if the previous dose was well tolerated.

To ensure an appropriate titration process, it is recommended to use bisoprolol in the initial stages of treatment. dosage form tablets 2.5 mg.

The recommended initial dose is 1.25 mg 1 time per day. Depending on individual tolerance, the dose should be gradually increased to 2.5 mg, 3.75 mg, 5 mg, 7.5 mg and 10 mg 1 time per day. Each subsequent dose increase should be carried out at least 2 weeks later. If increasing the dose of the drug is poorly tolerated by the patient, then a dose reduction is possible.

During titration, regular monitoring of blood pressure, heart rate and the severity of symptoms of chronic heart failure is recommended. Worsening of the symptoms of chronic heart failure is possible from the first day of using the drug.

If the patient does not tolerate the maximum recommended dose of the drug, then a gradual dose reduction should be considered.

During the titration phase or after it, a temporary worsening of chronic heart failure, arterial hypotension or bradycardia is possible. In this case, it is recommended, first of all, to adjust the doses of concomitant therapy drugs. It may also be necessary to temporarily reduce the dose of Concor or discontinue it. After stabilization of the patient's condition, the dose should be re-titrated or treatment should be continued.

Duration of treatment for all indications

Treatment with Concor is usually long-term.

Elderly patients do not require dose adjustment.

Because There is not enough data on the use of the drug Concor in children; it is not recommended to prescribe the drug to children under 18 years of age.

To date, there is insufficient data regarding the use of the drug Concor in patients with chronic heart failure in combination with diabetes mellitus type 1, severe renal and/or liver dysfunction, restrictive cardiomyopathy, birth defects heart or heart valve disease with severe hemodynamic disturbances. Also, sufficient data have not yet been obtained regarding patients with chronic heart failure with myocardial infarction within the last 3 months.

Release forms

Film-coated tablets 5 mg and 10 mg.

Concor- a selective beta1-blocker, without its own sympathomimetic activity, does not have a membrane-stabilizing effect.

It has only slight affinity for beta2-adrenergic receptors of the smooth muscles of the bronchi and blood vessels, as well as for beta2-adrenergic receptors involved in the regulation of metabolism. Therefore, bisoprolol (the active ingredient of the drug Concor) generally does not affect resistance respiratory tract and metabolic processes in which beta2-adrenergic receptors are involved.

The selective effect of the drug on beta1-adrenergic receptors persists beyond the therapeutic range.

Bisoprolol does not have a pronounced negative inotropic effect.

Bisoprolol reduces the activity of the sympathoadrenal system by blocking beta1-adrenergic receptors of the heart.

When administered once orally in patients with coronary artery disease without signs of chronic heart failure, bisoprolol reduces heart rate, reduces the stroke volume of the heart and, as a result, reduces the ejection fraction and myocardial oxygen demand. With long-term therapy, the initially elevated TPR decreases. A decrease in renin activity in blood plasma is considered as one of the components of the hypotensive effect of beta-blockers.

The maximum effect of the drug is achieved 3-4 hours after oral administration. Even when bisoprolol is prescribed once a day, it therapeutic effect persists for 24 hours due to the fact that its T1/2 from blood plasma is 10-12 hours. As a rule, the maximum reduction in blood pressure is achieved 2 weeks after the start of treatment.

Pharmacokinetics

After oral administration, Concor is almost completely (>90%) absorbed from the gastrointestinal tract. Food intake does not affect bioavailability. The clearance of bisoprolol is determined by the balance between excretion by the kidneys unchanged (about 50%) and metabolism in the liver (about 50%) to metabolites, which are also excreted by the kidneys.

Indications

arterial hypertension;
IHD: stable angina;
chronic heart failure.

Contraindications

acute heart failure;
chronic heart failure in the stage of decompensation, requiring therapy with drugs with a positive inotropic effect;
cardiogenic shock;
2nd and 3rd degree AV block, without pacemaker;
SSSU;
sinoatrial block;
severe bradycardia (heart rate less than 60 beats/min.);
pronounced decrease in blood pressure (systolic blood pressure less than 100 mmHg);
history of severe forms of bronchial asthma and COPD;
severe peripheral disturbances arterial circulation, Raynaud's disease;
pheochromocytoma (without simultaneous use of alpha-blockers);
metabolic acidosis;
age under 18 years (insufficient data on effectiveness and safety);
hypersensitivity to the components of the drug.

Special instructions

The patient should not abruptly interrupt treatment or change the recommended dose without first consulting a doctor, as this may lead to a temporary deterioration in heart function. Treatment should not be interrupted suddenly, especially in patients with coronary artery disease. If discontinuation of treatment is necessary, the dose should be reduced gradually.

Tri- and tetracyclic antidepressants, antipsychotics(neuroleptics), ethanol (alcohol), sedatives and hypnotics increase the depression of the central nervous system.

On initial stage Patients treated with Concor require constant medical supervision.

The drug should be used with caution in diabetes mellitus with significant fluctuations in blood glucose concentrations (symptoms of severe hypoglycemia, such as tachycardia, palpitations or increased sweating may be masked), in patients on a strict diet, during desensitizing therapy, 1st degree AV block, Prinzmetal's angina, disorders of the peripheral arterial circulation of the lungs and moderate degree(at the beginning of therapy, an increase in symptoms may occur), with psoriasis (including a history).

Respiratory system: for bronchial asthma or COPD, simultaneous use of bronchodilators is indicated. In patients with bronchial asthma possible increase in respiratory tract resistance, which requires more high dose beta2-adrenergic agonists.

Allergic reactions: beta blockers, including Concor, may increase sensitivity to allergens and severity anaphylactic reactions due to weakening of adrenergic compensatory regulation under the influence of beta-blockers. Therapy with epinephrine (adrenaline) does not always give the expected therapeutic effect.

When conducting general anesthesia the risk of beta-adrenergic receptor blockade should be taken into account. If it is necessary to discontinue therapy with Concor before surgery, this should be done gradually and completed 48 hours before general anesthesia. The anesthesiologist should be warned that the patient is taking the drug Concor.

In patients with pheochromocytoma, Concor can be prescribed only while using alpha-blockers.

When treated with Concor, the symptoms of hyperthyroidism may be masked.

Impact on the ability to drive vehicles and operate machinery

Concor does not affect the ability to drive vehicles, according to the results of a study in patients with coronary artery disease. However, due to individual reactions, the ability to drive a car or work with technical equipment complex mechanisms may be broken. This should be noted special attention at the beginning of treatment, after changing the dose, and also with simultaneous use of alcohol.

Side effect

bradycardia (in patients with chronic heart failure);
worsening symptoms of chronic heart failure (in patients with chronic heart failure);
feeling of coldness or numbness in the limbs;
pronounced decrease in blood pressure (especially in patients with chronic heart failure);
orthostatic hypotension;
dizziness;
headache;
loss of consciousness;
depression;
insomnia;
hallucinations;
decreased tear production (should be taken into account when wearing contact lenses);
hearing impairment;
conjunctivitis;
bronchospasm in patients with a history of bronchial asthma or obstructive airway diseases;
nausea, vomiting;
diarrhea, constipation;
muscle weakness;
muscle cramps;
potency disorders;
skin itching;
rash;
hyperemia of the skin;
allergic rhinitis;
asthenia (in patients with chronic heart failure);
increased fatigue.

Drug interactions

The effectiveness and tolerability of bisoprolol may be affected by the simultaneous use of other drugs. This interaction can also occur when two drugs are taken within a short period of time. The doctor must be informed about the use of other medications, even if used without a prescription.

Treatment of chronic heart failure

Class 1 antiarrhythmic drugs (for example, quinidine, disopyramide, lidocaine, phenytoin, flecainide, propafenone), when used simultaneously with bisoprolol, can reduce AV conduction and cardiac contractility.

Blockers of slow calcium channels such as verapamil and, to a lesser extent, diltiazem, when used simultaneously with bisoprolol, can lead to a decrease in myocardial contractility and impaired AV conduction. In particular, intravenous administration of verapamil to patients taking beta-blockers can lead to severe arterial hypotension and AV blockade. Antihypertensive drugs central action(such as clonidine, methyldopa, moxonidine, rilmenidine) can lead to a decrease in heart rate and decreased cardiac output, as well as to vasodilation due to a decrease in central sympathetic tone. Abrupt withdrawal, especially before discontinuation of beta-blockers, may increase the risk of developing “rebound” arterial hypertension.

Combinations requiring special caution

Treatment of arterial hypertension and angina pectoris

All indications for use of the drug Concor

Slow calcium channel blockers, dihydropyridine derivatives (for example, nifedipine, felodipine, amlodipine), when used simultaneously with bisoprolol, may increase the risk of arterial hypotension. In patients with chronic heart failure, the risk of subsequent deterioration of cardiac contractile function cannot be excluded.

Class 3 antiarrhythmic drugs (for example, amiodarone), when used simultaneously with Concor, may increase AV conduction disturbances.

The effect of beta blockers on local application(For example, eye drops for the treatment of glaucoma) may increase systemic effects bisoprolol (lower blood pressure, lower heart rate).

Parasympathomimetics, when used simultaneously with bisoprolol, may increase AV conduction disturbances and increase the risk of bradycardia.

When used simultaneously with Concor, the hypoglycemic effect of insulin or oral hypoglycemic agents may be enhanced. Symptoms of hypoglycemia, in particular tachycardia, may be masked or suppressed. Such an interaction is more likely when using non-selective beta-blockers.

General anesthesia agents can increase the risk of cardiodepressive effects, leading to arterial hypotension.

Cardiac glycosides, when used simultaneously with bisoprolol, can lead to an increase in impulse conduction time, and thus to the development of bradycardia.

Nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce the hypotensive effect of Concor.

The simultaneous use of Concor with beta-agonists (for example, isoprenaline, dobutamine) may lead to a decrease in the effect of both drugs.

The combination of bisoprolol with adrenergic agonists that affect alpha and beta adrenergic receptors (for example, norepinephrine, epinephrine) may enhance the vasoconstrictor effects of these drugs due to their action on alpha adrenergic receptors, leading to an increase in blood pressure. Such an interaction is more likely when using non-selective beta-blockers.

Antihypertensive drugs, as well as other drugs with a possible antihypertensive effect (for example, tricyclic antidepressants, barbiturates, phenothiazines) can enhance the hypotensive effect of bisoprolol.

Mefloquine, when used simultaneously with bisoprolol, can increase the risk of bradycardia.

MAO inhibitors (except MAO B inhibitors) may enhance the hypotensive effect of beta-blockers. Concomitant use may also lead to the development of a hypertensive crisis.

Analogs medicinal product Concor

Structural analogues of the active substance:

Use in children

Contraindicated in children and adolescents under 18 years of age (there is insufficient data on the effectiveness and safety of the drug).

Use during pregnancy and breastfeeding

The use of Concor during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

Beta blockers reduce blood flow to the placenta and may affect fetal development. Blood flow in the placenta and uterus should be carefully monitored, as well as the growth and development of the unborn child should be monitored, and in the event of undesirable manifestations in relation to pregnancy or the fetus, alternative therapeutic measures should be taken. The newborn should be carefully examined after birth. In the first 3 days of life, symptoms of bradycardia and hypoglycemia may occur.

There is no data on the excretion of bisoprolol in breast milk. Taking Concor is not recommended for women during lactation. If necessary, use the drug during lactation breast-feeding should be stopped.

Currently, diseases associated with the cardiovascular system are extremely common.

Just a few decades ago they were mainly elderly people, but today age does not matter.

Patients are forced to undergo treatment and take special drugs prescribed by the doctor.

Quite often, doctors prescribe Concor, which has a hypotensive effect. This medication significantly improves the patient's condition. However, like all drugs, Concor also has side effects. Before using this medicine, the patient should read the list of contraindications.

Letters from our readers

Subject: Grandma's blood pressure has returned to normal!

To: Site Administration

Christina
Moscow

My grandmother's hypertension is hereditary - most likely, I will have the same problems as I grow older.

Concor is a medicine used for various disorders of the heart muscle. Designed to reduce blood pressure and normalize heart function.

The active ingredient is bisoprolol. Key Features:

type: beige or lemon-colored tablets;
dosage: 5 or 10 mg active substance in a tablet;
group: the medicine is intended to reduce blood pressure in hypertension, angina, ischemia and other diseases;
compound: active substance(bisoprolol fumarate), additional ingredients – crospovidone, calcium hydrogen phosphate, cellulose, titanium dioxide.
reception: once a day.

The action of Concor is to reduce the heart rate and normalize its rhythm. Gently lowers blood pressure and increases the supply of oxygen to the heart muscle.

Even if the drug is taken correctly, it can cause the following negative consequences:

Gastrointestinal tract: dryness, nausea leading to vomiting, diarrhea, liver dysfunction, change in taste, constipation;
nervous system: nightmares, anxiety, lethargy, migraine, dizziness, convulsions, asthenia, drowsiness or insomnia, panic, fainting, depression;
vascular and cardiac system: sharp decrease in blood pressure, numbness of fingers and limbs, bradycardia, vasospasm;
breathing: shortness of breath, rhinitis, bronchospasm;
organs of vision: feeling of dryness in the eyes, decreased vision, inflammation;
musculoskeletal system: pseudorheumatic back pain, muscle weakness, arthralgia, calf muscle cramps;
skin: hyperhidrosis, hair loss, psoriasis, rash, redness of the dermis;
sense organs: hearing impairment or partial loss;
genitourinary system: decreased potency, decreased libido;
blood parameters: decrease in the number of platelets and leukocytes, increase in triglyceride levels.

In patients suffering hypertension and angina pectoris adverse reactions appear quite often on initial stage therapy. Usually they are not pronounced and disappear approximately 14 days after the start of treatment.

Many patients are interested in whether Concor has side effects for women during pregnancy. After all, the period of bearing a child is a difficult process, and you have to take care not only of your own health, but also of the safety of the unborn baby. Most experts do not recommend combining use of this medicine during this period. The only exceptions are critical situations when there is simply no other choice.

The drug does not have negative impact on a woman’s health, but can have a detrimental effect on the development of the fetus. The instructions indicate that the use of the product is allowed only in cases where the benefit for the pregnant woman is several orders of magnitude higher than the risk negative influence per child. It is strictly forbidden to prescribe medicine to yourself; it should be used only as prescribed by a specialist.

Before you prescribe Concor to the expectant mother, the doctor must consider everything possible risks for the baby. The difficulty is that the effect of the drug on the fetus has not yet been sufficiently studied. However, it is well established that the use of Concor in some cases causes a decrease in blood flow to the placenta, as a result of which the child may develop certain pathologies. Therefore, during therapy, constant monitoring of the state of blood flow and fetal development is necessary.

If a woman took Concor during pregnancy, the newborn must be diagnosed after birth, as he may show signs of hypoglycemia or bradycardia. Usually these pathologies are detected in the first 2 days of life.

Thus, we can conclude that in exceptional cases, pregnant women can also take the drug as prescribed by the doctor, but it is important to strictly follow the dosage and undergo the necessary studies.

Practitioners have developed some recommendations that will help minimize the side effects of taking it.

You should not stop taking Concor at once. It is necessary to gradually reduce the dose so as not to harm the heart and blood vessels.
Patients undergoing therapy should regularly visit their doctor, who will check their blood pressure. Appointment possible additional examinations: electrocardiogram, checking the frequency of contractions of the heart muscle and others.
In the case of an upcoming operation, the patient should gradually reduce the dose of the drug several days before it and 2 days before surgical intervention completely stop using the medication. It is also necessary to notify the surgeon and anesthesiologist about the use of Concor.
Man using contact lenses You will most likely feel that the mucous membrane of the eye has become dry and more sensitive to the lenses. If possible, it is recommended not to wear them during therapy.
You should strictly follow the dosage regimen, without increasing or decreasing the dosage yourself. The occurrence of adverse reactions should be reported to your doctor immediately.

The effect of the drug on the ability to drive a car or operate any machinery has not been identified, but individual human reactions can be unpredictable. Therefore, the patient needs to be attentive to his feelings, especially in the first stages of therapy or when changing the dosage.

The following diseases are contraindications for use:

Caution is observed when using the product by people with a history of liver dysfunction (severe), heart attacks, diabetes, psoriasis, kidney failure, congenital heart disease.

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The drug Concor is a selective β1-blocker. It is used as part of therapy various pathologies, including hypertension and cardiac ischemia. Because of high efficiency It is enough to take the drug once a day: the effect occurs after a few hours and lasts the whole day. The price at which you can buy Concor is about 280-350 rubles per package, including 50 tablets.

Indications

Concor tablets are prescribed to patients if they have any of the following diseases:

Arterial hypertension;
Cardiac ischemia;
Stable angina;
Heart failure.

Composition and release form

Concor is presented in tablets of 5 mg and 10 mg, and Concor Cor is available in tablets of 2.5 mg (and there are no other differences between the drugs, except dosages). The tablets are convex on both sides and have a coating. Their hue varies from yellow to orange.

The composition of the drug is as follows:

Useful properties

Being a selective β1-blocker, Concor has 3 useful actions on the body:

Antihypertensive (normalization of high blood pressure).
Antiarrhythmic (normalization of heart rate).
Antianginal (elimination of manifestations of ischemia).

During the first days of treatment, vascular resistance to peripheral blood flow increases slightly. This is a consequence of the activation of alpha adrenergic receptors. After 1-3 days, the indicators return to their original values. Subsequently, vascular resistance begins to decrease.

The antihypertensive effect of Concor is due to the fact that under the influence of the drug:

The minute volume of blood decreases;
The activity of the renin-angiotensin system is suppressed;
Stimulated by the central nervous system;
Response sensitivity is restored when pressure decreases.

The drug also relieves arrhythmia, eliminating negative factors- tachycardia, arterial hypertension, and slowing down the spontaneous excitability of pacemakers. Signs of ischemia disappear due to a decrease in the volume of oxygen required by the myocardium for nutrition. This occurs due to a slowdown in heart contractions, an increase in diastole length, and stimulation of cardiac muscle perfusion.

Subject to acceptance therapeutic doses the drug has a less noticeable effect on β1-adrenergic receptors than non-selective analogues. They are located in the skeletal muscles, smooth muscles of peripheral arteries, and pancreas. Also, no violations occur during treatment with Concor carbohydrate metabolism, sodium is not retained in the body.

Analogs

Concor has large number analogues that have a similar effect on the body. These are the following drugs:

Niperten.
Bisoprolol-Verte.

According to reviews, many patients resort to Concor analogues because of their lower price. The most economical is Bisoprolol-Verte. It costs about 60 rubles per package, or 5-6 times cheaper than Concor.

Concor drug, action, description, side effects

Concor and bisoprolol for hypertension and heart disease

A quick word about medications. Bisoprolol

Instructions

Before taking Concor, you should carefully study the instructions, especially regarding maximum dosages. Self-prescription of the drug is unacceptable. It is released from pharmacies only with a doctor's prescription.

Ingestion

The drug is drunk once every 24 hours with water. Concor can be taken when convenient, regardless of food. However, the drug cannot be chewed or crushed into powder - only swallowed whole.

Arterial hypertension and stable angina

The standard dose for starting treatment with Concor is 5 mg. 1 time per day. In the absence desired effect the dose can be increased, but to a maximum of 20 mg.

CHF

Use Concor for docking CHF symptoms It is possible only under the supervision of doctors. First, you need to go through a titration phase, during which you should drink 1.25 mg. medications per day. If it is well tolerated, the dose can be gradually increased by 1.25 mg. at intervals of 2 weeks. Limit daily dosage reaches 10 mg.

During the titration phase and subsequently, a temporary aggravation of the course of CHF, as well as the occurrence of bradycardia and hypotension, is possible. Then you should temporarily reduce the dosage of the drug or stop it completely.

The course of treatment can be repeated after the patient’s condition normalizes.

Duration of treatment

The treatment process with Concor takes a long time. Only a doctor can be more precise about the timing of taking the pills based on tests and interviews with a specific patient.

Impaired kidney or liver function

In most cases, minor abnormalities in the functioning of the kidneys and liver do not require changing the dosage of Concor. However, in case of severe pathologies of these organs, no more than 10 mg of the drug can be taken per day.

Increasing the dosage should be done carefully and always under the supervision of a doctor.

Elderly patients

Children and teenagers

The medicine is not recommended for people under 18 years of age. Research on how Concor works on developing organism, were not carried out. There is insufficient data to support the safety of treatment with this drug in minors.

Contraindications

Concor should not be taken by people who have the following contraindications:

Hypersensitivity to bisoprolol or other components;
Decompensated heart failure;
Sinoatrial block;
Cardiogenic shock;
Metabolic acidosis;
Sick sinus syndrome;
Severe hypotension;
AV block 2nd and 3rd degree;
Pheochromocytoma;
Severe bradycardia;
Severe asthma or chronic pathology lungs with obstruction;
Severe arterial blood flow disorders or Raynaud's syndrome;
Minor age.

Use during pregnancy and breastfeeding

The fact is that under the influence of a beta-blocker, the blood supply to the placenta decreases. Lack of oxygen can negatively affect fetal development.

If a pregnant woman takes Concor, she should be observed by a doctor. If abnormalities are detected in the fetus, the drug should be immediately discontinued, and the woman should be prescribed appropriate medical procedures.

Also, a woman who took Concor during pregnancy may give birth to a child with hypoglycemia and bradycardia. It is important to monitor the signs of these diseases in the first days of life.

Studies on the penetration of bisoprolol into breast milk was not carried out. To prevent risks, a woman should stop taking the drug during lactation. Otherwise, she should switch the newborn to formula milk.

Side effects

The instructions for the drug list a large number of side effects. In most cases, they appear only on early stage treatment, more often in patients with hypertension or angina pectoris. Then everything goes away on its own in a couple of weeks or less.

The most common adverse reactions to Concor are:

Dizziness and headaches;
Severe fatigue;
Asthenia, bradycardia (with CNS);
Nausea with vomiting;
Constipation and diarrhea.

Interaction with other drugs

The instructions for use also contain an extensive list of medications that are not recommended to be taken simultaneously with Concor. Such combinations may affect the effectiveness and tolerability of bisoprolol. Therefore, you should tell your doctor if you are taking other medications, including those sold without a prescription.

Prohibited combinations

When they are combined, a decrease in heart rate, a decrease in cardiac output and vasodilation is possible. It is also impossible to abruptly cancel other antihypertensive drugs - otherwise the risk of “rebound” hypertension will increase.

Combinations that require caution

The antihypertensive effect of Concor can be enhanced by any other drugs with similar effects, as well as local beta-blockers (including eye drops from glaucoma) and MAO inhibitors (except MAO B). Such combinations create a risk of overdose.

Nonsteroidal anti-inflammatory drugs and β-adrenergic agonists, on the contrary, often suppress the antihypertensive effect of Concor. As a result, treatment is significantly delayed or becomes meaningless.

Every year in the world the number of people suffering from cardiovascular diseases is steadily growing. Various medications are used to treat these ailments; for example, Concor, the indications for the use of this drug specifically relate to this profile of diseases. The medicine belongs to the group of cardioselective beta-blockers. Concor has been successfully used in cardiology since the early 60s of the twentieth century. It occupies one of the leading places by purpose among medications used for therapy cardiovascular diseases.

Composition and mechanism of action of the drug

The basic component of Concor is bisoprolol, a beta-adrenergic blocking substance. The effect of the drug begins 1-3 hours after administration and lasts about 24 hours. Concor has a hypothetical effect by reducing cardiac output. By reducing the diastolic pressure of oxygen supply to the myocardium, Concor has an antianginal effect. At systematic reception the drug, the patients’ well-being improves significantly.

Indications for use of Concor tablets

A drug with this name is prescribed for major cardiac syndromes: arterial hypertension, coronary and heart failure, disorders heart rate. The use of a coronary is advisable in the treatment of patients with left ventricular hypertrophy, symptoms coronary disease, primarily angina pectoris, in persons who have suffered a myocardial infarction.

The results of clinical and pharmacological studies have proven the effectiveness of Concor in the treatment of arterial hypertension, coronary insufficiency, prevention of heart rhythm disturbances, circulatory failure. Medicine has a sufficient amount of data indicating the drug’s ability to improve the prognosis of patients’ lives arterial hypertension.

Instructions for use and dosage

The medicine is available in the form of film-coated tablets. The package contains an annotation that describes in detail how to take the drug. Chewing the medicine is not recommended. Concor is taken orally in the morning, on an empty stomach. The dose of the drug is prescribed individually in each individual case, based on the patient’s condition andconcomitant diseases. General recommendations for use:

For the treatment of angina pectoris, a single daily dose 5 mg - 1 tablet of Concor 5 mg. If necessary, the rate is increased to 10 mg.
When treating chronic heart failure, the medication is prescribed according to the following scheme: 1 week - 1.25 mg Concor, 2 - 2.5 mg, 3 - 3.75 mg, from 4 to 7 - 5 mg, from 8 to 11 - 7.5 mg, starting from 12 - 10 mg.
Patients with arterial hypertension, heart rhythm disturbances, and circulatory failure are prescribed 2.5 mg per day. Maximum dose– 20 mg.

Side effects and contraindications

Undesirable effects, developing as a result of taking Concor, is an extremely rare phenomenon, observed in 1% of patients. For other people, if the recommended dosage is observed, the treatment is positive, without side effects. If during therapy with Concor you find yourself alarming symptoms or feel discomfort, immediately seek advice from your doctor. He will appreciate the feasibility further treatment with this drug. Side effects:

fatigue, dizziness, headaches, sleep disturbances, depression, nightmares, in rare cases– hallucinations;
impaired lacrimation, non-infectious conjunctivitis;
bradycardia, orthostatic hypotension;
shortness of breath, apnea, difficulty breathing;
diarrhea, constipation, nausea, vomiting, colic;
impotence;
feeling of cold, numbness of the limbs;
hearing impairment;
allergic rhinitis;
skin redness, itching, peeling;
muscle weakness cramps;
hepatitis.

Systematic and long-term therapy with Concor significantly improves the course of diseases, reduces the likelihood of complications, and prolongs people’s lives. The medicine is contraindicated for pregnant, nursing mothers, patients with in a state of shock, under anesthesia, during a strict diet. The medication is prescribed with caution to patients suffering from:

Analogues of the drug Concor

In the treatment of cardiac diseases, medications containing bisoprolol or belonging to the group of selective agents are substitutes for tablets. Such drugs have similar action, but differ in dosage, contraindications, side effects. Selective action drugs that replace Concor are:

Where to buy and how much do the tablets cost?

Concor is sold in free access in pharmacies, available without a doctor's prescription. The cost of the drug varies from 179 to 200 rubles. per pack of 2.5 mg tablets 30 pcs., from 230 to 426 rubles. – 5 mg 30 pcs., from 342 to 456 rubles. – 5 mg 50 pcs., from 490 to 465 rubles. – 10 mg 30 pcs. The price of the medicine depends on the manufacturer (Norway, Hungary or Germany). Before taking Concor, consult your doctor and carefully read the leaflet.