Magne b6 side effects in children. Why do children need magnesium and when should they take medications with it? The benefits of magnesium B6 for the body

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Magnesium B6 instructions

Instructions Magnesium B6 is included in each package of the drug in any of its varieties. It contains information about the composition of the drug and its pharmacological action, as well as about indications for use and when the drug Magnesium B6 is contraindicated. In addition, the instructions provide the consumer with a clear description of the method of its use and dosage regimen. Thus, when purchasing the vitamin preparation Magne B6 at the pharmacy, before you start taking it, you need to study the instructions for it.

Release form and composition of Magne B6

The active ingredients of the drug are pyridoxine and magnesium lactate.

Magne B6 tablets

The tablets are oval in shape, shiny and smooth. White color.

Each of them contains the required amount of active substance, which corresponds to 48 milligrams of magnesium. The required proportions of sucrose, heavy kaolin, acacia gum, carboxypolymethylene, talc, magnesium stearate, powdered Carnauba wax, and titanium dioxide are used as excipients.

The drug is sold in tablet form in 50 pieces in individual packaging.

Magne B6 ampoules

The drug Magne B6 in ampoules goes on sale in the form of a clear solution that is taken orally. The color of the solution is brown, the smell is caramel. Each package contains ten ampoules with a volume of 10 milliliters, the glass of which is dark.

Each ampoule contains the required amount of active ingredient and magnesium pidolate, which corresponds to 100 milligrams of magnesium. As auxiliary required proportions added substances: sodium disulfite, sodium disaccharinate, caramel with cherry flavoring additives, purified water.

Magne B6 forte

The tablets have an oval shape and a shell white. They are characterized by biconvexity.

They go on sale in packages of 30 or 60 pieces, each of which contains magnesium citrate and pyridoxine hydrochloride. As auxiliary substances, the drug is supplemented with the following substances: lactose, macrogol-6000, magnesium stearate, hypromellose 5 mPa and titanium dioxide (E171), as well as the required amount of talc.

Storage conditions

The drug should be stored in dry, shaded areas out of reach of children. The air temperature in them should not exceed 25 degrees.

Best before date

Magne B6 in tablet form can be stored for two years.

The drug in ampoules can be stored for a period of three years.

Vitamin Magnesium B6: pharmacology

Magne B6 is a magnesium preparation.

Representing a vital element found in each of the tissues of the body, the presence of which is necessary for normal functioning cells. In addition, its participation in most metabolic processes in the body and the regulation of such functions as the transmission of nerve impulses and the ability to muscle contraction is considered quite important.

It is known that the intake of magnesium into the body occurs primarily through nutrition, and if it is disrupted, a deficiency may occur. essential microelement. This is typical for those who are keen on reduction diets. Also, situations may arise for the body that the need for magnesium becomes increased. The reason for this may be stress, pregnancy, the use of diuretic drugs, as well as increased mental and exercise stress.

Vitamin B6 (pyridoxine) is also a participant in many metabolic processes in the body, and also regulates the metabolism of the nervous system. Being part of the drug, the vitamin helps improve the absorption of magnesium and increases its ability to penetrate cells.

Why is Magnesium B6 needed (indications)

The drug is indicated for use in cases where magnesium deficiency is established in the body.

Contraindications

Despite the fact that Magne B6 is a vitamin preparation, there are contraindications to its use. You should be aware that the use of Magnesium B6 is undesirable in the presence of the following conditions:

• In case of hypersensitivity to the components of the drug;
• With pronounced renal failure;
• For phenylketonuria;
• Taking tablets is contraindicated for children under six years of age;
• Taking the solution is contraindicated for children under one year of age;
• For fructose intolerance;
• In a syndrome where the adsorption of glucose-containing substances is impaired;
• With severe deficiency of sucrose-isomaltase.

Magnesium B6 instructions for use

The duration of taking the vitamin preparation Magne B6 is approximately one month. When the concentration level of magnesium in the blood returns to normal, the drug should be discontinued.

Magne B6 tablets: application

Take the tablet during meals with at least a glass of water.

For adults and children over the age of twelve, 6-8 pieces of Magne B6 or 3-4 pieces of Magne B6 forte per day in two or three doses.

For children over six years of age, whose body weight exceeds 20 kilograms, 4-6 pieces of Magne B6 or 2-3 pieces of Magne B6 forte.

Magne B6 ampoules: application

Before use, the contents of the ampoule should be dissolved in half a glass of water and taken with food.

For adults, 3-4 pieces per day in two or three doses.

For children over one year of age, body weight exceeding 10 kilograms, 1-4 pieces per day in two or three doses.

Use of Magnesium B6 during pregnancy

Although negative influence The drug has not been identified on fetal development when taken by pregnant women; however, its use during pregnancy is allowed only as prescribed by a doctor, as well as under his supervision.

But when breastfeeding, the use of the drug is not advisable, since magnesium passes into mother’s milk.

Special instructions for use Magnesium B6

If the patient has moderate renal failure, the drug is prescribed with caution.

For patients suffering diabetes mellitus When prescribing the drug, you should take into account the sucrose content in its shell.

If a deficiency of magnesium in the body is also accompanied by a deficiency of calcium, then before starting to take calcium supplements, the deficiency of magnesium should be eliminated.

If it is necessary to combine tetracycline and Magnesium B6 drugs, an interval of three hours must be maintained between them.

At frequent use laxatives, alcohol abuse, as well as excessive mental and physical stress, the need for magnesium in the body increases, which leads to the development of its deficiency.

Side effects

A side effect of taking the drug may include allergic reactions.

Sometimes the gastrointestinal tract may cause attacks of nausea and vomiting, constipation and symptoms of flatulence, as well as abdominal pain.

Overdose

If the patient suffers from renal failure, then he may experience magnesium poisoning, while with normal functioning there is no toxic reaction.

Symptoms of poisoning: a sharp decrease in blood pressure; attacks of nausea accompanied by vomiting; inhibition of reflexes, respiratory depression, onset of coma; paralysis and cardiac arrest, anuria.

Possible treatment: by dehydration and forced diuresis. If kidney function is insufficient, hemodialysis is required.

Drug interactions

The simultaneous use of magnesium and calcium preparations leads to a decrease in the absorption of magnesium from the gastrointestinal tract. intestinal tract.

Magnesium preparations can reduce the absorption of tetracycline drugs.

Magnesium preparations, when taken simultaneously with oral thrombolytic drugs, weaken their effect and can also reduce the absorption of iron by the body.

Magnesium B6 analogues

The vitamin preparation Magne B6 has analogs that are similar in pharmacological action. For example, the drugs Magnerot and Magnelis B6 are produced in tablet form.

Magnesium B6 prices

The cost of the vitamin preparation is quite high. So on average, it roughly ranges from 395 rubles per pack of ampoules with Magne B6 solution to 594 rubles per pack of Mangne ​​B6 tablets (50 pieces). The drug Magne B6 forte is even more expensive. Its cost per package is from 649 rubles to 686 rubles, depending on the number of tablets.

Magnesium B6 reviews

Reviews about the drug are only positive – there are no negative opinions. There are, of course, those who write that there is no tangible effect, but there are few of them. Mostly people are grateful to the drug for feeling good and feeling again born person. It is also noted that the drug effectively eliminates the consequences of magnesium deficiency, which is accompanied by irritability, apathy and sleep disturbances. There are a lot of reviews and it’s impossible to count them all, so in order not to offend anyone, we will cite the most recent one:

Marina: Of all vitamin preparations, that I happened to take, Magne B6 turned out to be the best. You can take vitamins even during pregnancy. After taking them, I noticed a surge of energy and a feeling of peace. It's a shame they cost so much.

Similar instructions:

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Motherwort forte and magnesium B6

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Calcium Active – detailed instructions

Sibazon application (tablets and solution)

MAGNE B6 is a magnesium preparation intended to cover the deficiency of this element in the human body and eliminate symptoms caused by its deficiency. MAGNE B6 is available in the form of film-coated tablets (blister with 10 tablets, a total of 5 blisters per package) and an oral solution (10 ampoules of 10 ml).

Composition of MAGNE B6 tablets

The active ingredients are:

• Magnesium lactate dihydrate – 470 mg (equivalent to 48 mg magnesium);
• Magnesium lactate dihydrate – 186 mg;
• Magnesium pidolate – 936 mg;
• Pyridoxine hydrochloride – 5 mg.

Composition of MAGNE B6 solution for oral administration

pharmachologic effect MAGNE B6

Magnesium is found in all tissues of the body and is vital for normal life cells. Magnesium takes part in most metabolic processes, for example in the regulation of muscle contraction and the transmission of nerve impulses. The main route of entry into the body of magnesium is food.

Magnesium deficiency occurs when gross violations diet, with an unbalanced diet. Relative magnesium deficiency is formed with increasing physiological need in this element, for example, during high physical and mental stress, pregnancy, stress.

The cause of magnesium deficiency may be the use of diuretics.

Vitamin B6 (pyridoxine) is involved in the metabolic processes of the central and peripheral nervous system and improves the absorption of magnesium digestive system and facilitates its entry into cells.

Moderate magnesium deficiency is indicated by its content in the blood serum of 12-17 mg/l (0.5 - 0.7 mmol/l). If magnesium becomes less than 12 mg/l, then severe deficiency of this element develops.

IN gastrointestinal tract Half of the magnesium taken is absorbed. Almost all mania (99%) enters the cells, with 1/3 distributed in the cells of smooth and striated muscles, and 2/3 in the cells bone tissue.

Magnesium is excreted by the kidneys. At least a third is excreted in urine dose taken magnesium

Indications for use of MANE B6

The drug is prescribed when actual magnesium deficiency is confirmed and symptoms such as increased irritability, sleep disturbances, stomach and intestinal cramps, tachycardia, fatigue, muscle pain and muscle cramps, tingling sensations in the limbs.

Contraindications

MAGNE B6 should not be used in cases of severe renal failure, phenylketonuria, or individual intolerance to the drug. Tablets are contraindicated in children under 6 years of age, solution - up to 1 year. Contraindications are also: fructose intolerance, glucose and galactose malabsorption syndrome, deficiency of the enzyme sucrase - isomaltase.

MAGNE B6 should be used with caution in cases of moderate renal failure, due to the likelihood of increased magnesium levels in the blood serum.

You should stop taking the drug while breastfeeding, due to the fact that magnesium enters the breast milk.

For pregnant women, MANE B6 is prescribed by a doctor.

MAGNE B6 instructions for use

According to the instructions for the drug, tablets should be taken in 6-8 tablets. per day, children over 6 years old (body weight more than 20 kg) – 4-6 tablets. per day.

The solution is taken 3-4 ampoules per day by adults, and children over a year old(with a body weight of more than 10 kg) take 10-30 mg/kg, which corresponds to 1-4 ampoules.

The daily dose is divided into two to three doses. Take MAGNE B6 with meals and a glass of water.

An ampoule of MAGNE B6 solution is dissolved in half a glass of water. Take with meals 2-3 times a day.

The course of treatment is 1 month.

During treatment, the magnesium content in the blood serum should be monitored, and when its level normalizes, the drug should be discontinued.

Adverse reactions and interactions with other medications

Digestive disorders, constipation, nausea, vomiting, flatulence, and abdominal pain are possible.

Phosphorus or calcium preparations, when taken simultaneously with MAGNE B6, impair the absorption of magnesium in the intestine.

MAGNE B6 will reduce the absorption of tetracycline, so a pause of 3 hours should be taken between doses of these medications.

Magnesium reduces the effectiveness of blood clot medications taken orally, as well as iron supplements.

Pyridoxine reduces the activity of levodopa.

Overdose of MAGNE B6

There is no toxic effect of magnesium in normal renal function. In case of renal failure, an increase in magnesium content in the blood serum and the manifestation of toxic effects are possible: nausea, vomiting, decreased blood pressure, slowed reflexes, depression, ECG changes, respiratory depression, cardiac arrest and paralysis, coma, anuria.

Treatment for overdose: forced diuresis with rehydration, in case of renal failure - hemodialysis, peritoneal dialysis.

additional information

The tablets contain sucrose, which must be taken into account when taking MAGNE B6 by patients with diabetes mellitus.

If there is a simultaneous deficiency of magnesium and calcium, treatment begins with replenishing the deficiency of magnesium, after which calcium supplements can be administered.

An increase in the need for magnesium above the physiological norm is possible with the use of laxatives, alcohol, and physical and mental stress.

MAGNE B6 ampoules contain sulfite, which can cause allergic reactions in people with individual intolerance to this component.

The drug does not affect the ability to drive vehicles.

MAGNE B6 is available without a prescription.

Shelf life and storage of MAGNE B6

Store tablets in a dark, dry place at an air temperature no higher than 25°C.

Store the solution in a dark place at the same temperature.

The shelf life of the tablets is 2 years, the solution is 3 years.

During pregnancy, a woman needs more than ever to receive a complete set of vitamins and microelements into her body. Not always enough of them are supplied with food.

Therefore, the observing gynecologist can prescribe medications that provide the expectant mother’s body with all the elements essential for the normal development of the fetus.

One of these drugs could be Magne B6. Magnesium deficiency can cause different problems , both for the expectant mother and for the child she is carrying.

Indications for use during pregnancy

The drug "Magnesium B6" in the instructions for use for pregnant women contains the following readings to the reception:

• excessive nervousness, sleep disturbances;
• hypertonicity of the uterus, threat of miscarriage;
• excessive manifestations of toxicosis, especially in the early stages;
• spasms, pain in the intestines;
• lack of energy, rapid loss of strength, lethargy, general malaise;
• paresis of the limbs, convulsive muscle contractions, twitching;
• a sharp increase in hair loss;
• malnutrition;
• cardiopalmus.

Contraindications for use

Pregnant women with diabetes are not recommended to take Magne B6, since the drug contains polysaccharides, in particular sucrose.

Particular attention should be paid to the fact that Magna B6 contains fructose.

Individual intolerance to this monosaccharide also serves as a contraindication to the use of the drug. If there is a lack of magnesium, it is better for such women to prefer magnesium preparations that do not contain sweeteners.

If this pathology is present in mild form, then the drug can be used with caution.

Attention! One of the contraindications to the use of Magnesium B6, according to the instructions, is individual intolerance to the components of the drug, which contributes to the development of various allergic reactions.

Allergies can include rash or redness of the skin, runny nose and swelling.

Pregnancy radically changes all physiological processes in a woman’s body, therefore Even in the absence of a history of allergies, caution should be exercised when using new products! This should only happen under the supervision of the attending physician.

Instructions for use and dosage

The drug "Magne B6" is available in forms such as tablets and solution in ampoules. Pregnant women can only be prescribed it by their attending physician. Any form of the drug is taken with food.

According to the instructions for pregnant women “MagnesiumB6″contains instructions that the tablets do not need to be chewed or cracked. They must be swallowed with plenty of water.

The usual dosage is 6-8 tablets per day. The solution is taken in the amount of 3-4 ampoules per day.

Taking the drug requires a mandatory breakdown of the drug entering the body. As a rule, these are 2-3 doses per day with approximately equal intervals between uses.

When planning a pregnancy

Magnesium is one of the most important elements for the female body. It takes part in many vital processes and has a significant impact on reproductive system women.

This drug has a beneficial effect on the tone of the smooth muscles of the uterus and blood vessels supplying it.

When planning pregnancy, you should pay attention to the level of magnesium in the blood and prepare the body for the fact that the consumption of this microelement during pregnancy will increase sharply.

Therefore, care should be taken in advance to ensure that the female body is sufficiently supplied with this microelement.

During pregnancy

"Magne B6" did not show any results during clinical trials negative impact on a pregnant woman and the fetus she is carrying, therefore its use is permitted during pregnancy.

Gynecologists often recommend their patients to use this drug, as it has a positive effect on the state of the woman’s central nervous system, relieves irritability and nervousness, which is especially evident in the first trimester of pregnancy.

When taking the drug "Magnesium B6", the instructions for pregnant women during pregnancy should be studied. You must absolutely adhere to it.

In addition, magnesium has a good effect on the tone of the smooth muscles of the uterus, which helps prevent such a common problem as hypertonicity. Magnesium preparations help relieve spasms and eliminate nagging pain in the lower abdomen.

Today, most gynecologists prescribe this drug to their patients as a preventative measure, in the absence of the threat of abortion and other pregnancy problems.

Magnesium consumption during pregnancy increases by 100%, and a woman is not always able to get enough micronutrients from food. In addition, according to research, a product with magnesium and vitamin B6 is absolutely harmless.

Something to remember! The prescription of any medications, even the easiest and most useful ones, remains under the supervision of the observing gynecologist.

Duration of admission

The instructions for the drug "Magnesium B6" warn pregnant women that they should take the drug for 2-3 months.

The duration of medication for a pregnant woman is determined by the attending physician., based on observations of the patient’s condition and laboratory blood tests confirming the normalization of magnesium content.

In some cases, if the patient is prescribed a course of taking the drug in high dosage over a long period of time, various unpleasant symptoms. These include, for example, axonal neuropathy.

This neurological pathology side symptom characterize:

• constantly increasing tremor;
• numbness;
• tingling in the muscles of the limbs;
• decreased pain threshold;
• movement coordination disorder.

These manifestations, as a rule, disappear with drug withdrawal.

Interaction with other drugs

In cases where the use of tetracycline antibiotics is indicated for a pregnant woman, their intake and Magne B6 intake should be separated in time.

This is because Magnesium preparations significantly reduce the absorption capacity of the intestine in relation to tetracycline. The time difference between taking these drugs should be at least two hours.

Very often, pregnant women experience calcium deficiency.

If a woman expecting a child has a combined deficiency of magnesium and calcium, then Magne B6 is prescribed before taking medications to restore calcium levels. This is due to the fact that Calcium is well absorbed only when sufficient level magnesium

Possible side effects

According to the instructions for Magnesium B6, taking the drug can provoke the following reactions in the body:

• allergy;
• gagging;
• increased gas formation in the intestines;
• inability to empty the bowels;
• diarrhea;
• sharp or nagging pain in the lower abdomen.

Price of the drug, how to store

The price of the product varies depending on the region, the specific manufacturer of the drug and pricing policy pharmacy or pharmacy chain.

The drug should be stored out of the reach of children. It does not require special wound conditions.

Avoid contact with direct sun rays, that is, it is better to store it in a dark place. Storage temperature should not exceed 25 degrees.

Important know! The shelf life of Magne B6 is 3 years. Do not use medications after their expiration dates.

Analogs

Magnesium preparations are available under various names. Russian manufacturers produce Magnelis B6.

Also, such drugs as Magnicum, Magnefar, Magnit B6, as well as the Hungarian drug Beres Plus have a similar active ingredient with a slightly varying composition.

The above drugs are synonyms for Magne B6.

Substitutes for the drug are products with a similar composition, but produced by different pharmaceutical companies.

Analogues can be drugs that have the same effect, but have different active ingredients.

From this video you will learn about the drug “Magnesium B6”, as well as instructions for its use for pregnant women and pregnant women:

This video will tell you in detail about why magnesium is needed in the female body during pregnancy:

Medicines from any group should be used only on the recommendation of a doctor. Complaints about the ineffectiveness or harmful effects of drugs often arise due to their improper use. For example, magnesium B6: instructions for use of these tablets prescribe taking an average of 4 per day. But the doctor may suspect a patient has a magnesium deficiency or take into account the fact of pregnancy. In this case, for effectiveness, the dose must be doubled. The doctor will recommend stopping taking the pills if there are contraindications and advise adequate replacement.

What is magnesium B6, why do you need to take it?

The drug, intended to replenish the lack of magnesium in the body, consists of two active ingredients - magnesium and pyridoxine (vitamin B6), supplemented with stabilizing components. Available in the form of tablets and solution for oral use.

Why does the body need magnesium?

Mg is an important substance for the body; more than a third of metabolic processes cannot occur without its participation. The reserve of magnesium in the body is 20-30 g, the main depot is bones and teeth, one percent is in the blood, the rest is distributed in muscles and other tissues.

Greatest influence magnesium levels have an impact on the heart muscle. Without it, the immune system suffers:

• antibody production is disrupted;
• heart rhythm and blood pressure are disturbed;
• stress vulnerability increases and disruption of the nervous system begins;
• the risk of developing diabetes mellitus and its complications increases;
• calcium is not absorbed, so the condition suffers skeletal system, dental health deteriorates;
• protein synthesis and many metabolic processes are disrupted.

What are the benefits of vitamin B6

It takes part in many vital processes:

• normalizes blood lipid balance, cholesterol levels, reducing the risk of stroke, heart attack, atherosclerosis;
• regulates blood pressure;
• improves the contractility of the heart muscle;
• necessary for the processes of protein metabolism and the creation of red blood cells;
• improves memory and brain function;
• contributes to the prevention of cancer pathology;
• stimulates the immune system, increases the production of antibodies;
• improves hair health.

Indications for use of the drug

The inclusion of these two components in the composition of the drug is due not only to their beneficial effects on the heart, blood vessels and nervous system, but also by a mutually reinforcing effect.

Magnesium B6 intake is indicated for the following conditions:

• cardiovascular disorders;
• hypertension;
• heart failure;
• arrhythmias;
• atherosclerosis;
• coronary disease;
• cholesterolemia;
• increased blood clotting.
• pathologies of the nervous system;
• sleep disorders;
• irritability;
• depressive states;
• nervous tics;
• vegetative vascular dystonia.

Magnesium B6: what is it needed for during pregnancy

During pregnancy, the need for magnesium increases threefold. If a woman usually needs 300 mg of magnesium per day, then the pregnancy period requires 925 mg, and the lactation period requires 1250 mg.

Doctors recommend saturating the expectant mother’s body with magnesium even before pregnancy, at the planning stage. Women are explained which magnesium-rich foods they should eat more of. And the drug magnesium B6 is prescribed to strengthen the mother’s nervous and vascular systems, preparing them for a period of increased stress.

Taking magnesium B6 during pregnancy provides:

• reduction of excitation in the nervous system;
• prevention of muscle convulsions, tics, painful spasms;
• prevention of spontaneous abortions, as it helps reduce uterine tone;
• reducing the risk of developmental defects of the nervous and vascular system in a child, due to the properties of pyridoxine.

The use of any medications during pregnancy, including magnesium B6, must be agreed with your doctor.

Magnesium B6: instructions for use (tablets and ampoules)

The drug is indicated for use in adults and children. The dosage and duration of use is determined by the attending doctor. The drug is usually well tolerated, but taking magnesium B6 can cause side effects such as

• nausea, vomiting;
• increased gas formation in the intestines;
• diarrhea or constipation;
• allergic reactions;
• stomach ache;
• paresthesia, numbness, neuropathic phenomena.

Similar effects may accompany long-term use of the drug in high dosages.

The dose and duration of administration are determined by the degree of magnesium deficiency, according to laboratory research. Since magnesium is slowly accumulated by the body, the course of treatment is usually at least a month or two.

How to take magnesium B6 tablets

Daily dose tablets, which averages 6-10 for adults and 4-6 for children, are divided into several doses per day.

Take with food.

The tablets are swallowed whole without chewing.

Take with a glass of water; other liquid is not recommended.

How to take magnesium B6 in ampoules

It is worth remembering that the ampoules contain 100 mg of magnesium, and take this into account when dosing. This form of the drug is convenient for use in children and weakened bedridden patients, in people with impaired intake of solid food.

For children from one to six years old, the dose is individually calculated - 10-30 mg of magnesium per 1 kg of body weight. This usually amounts to 1-4 ampoules per day. The drug is not prescribed for children weighing less than 10 kg.

Children 6-12 years old take magnesium B6 ampoules 1-3 per day.

After the age of twelve, the daily dose can be 2-4 ampoules.

Having broken the tip of the ampoule, its contents are poured into a glass and mixed with 100 ml of water. Use immediately; the solution cannot be stored.

When not to take magnesium B6 - contraindications

The main contraindications include:

• renal failure;
• simultaneous administration with Levodopa;
• phenylketonuria;
• intolerance to components;
• less than a year old.
• the drug in tablet form is not given to children under six years of age;
• patients with glucose-galactose malabsorption syndrome;
• with fructose intolerance;
• with a lack of enzymes that break down sugars.

Magnesium B6 - analogues

Medicines with similar composition and action:

• Magnelis B6 (Russia);
• Magnefar and Magwit B6 (Poland);
• Beres plus (Hungary);
• Magnikum (Ukraine);
• Magnesium B6 Evalar;
• Magnesium plus B6.

Substitution can only take place after approval by the attending physician.

(pyridoxine hydrochloride) - 5 mg.

Heavy kaolin, carboxypolymethylene, sucrose, magnesium in the form of hydrosilicate (talc) and stearate, and acacia gum are used as auxiliary components.

Shell composition pills: acacia gum, sucrose, titanium dioxide, trace amounts of hydrous magnesium silicate and carnauba wax in powder form.

Part solution for oral administration includes 186 mg of magnesium lactate dihydrate and 936 mg of magnesium pidolate (which corresponds to a total Mg++ content of 100 mg), 10 mg of pyridoxine hydrochloride.

Auxiliary components: sodium disulfite and saccharinate, cherry and caramel flavoring, purified water.

Compound Magnesium B6 Forte tablets (Antistress): 618.43 mg magnesium citrate, 10 mg pyridoxine hydrochloride, anhydrous lactose, magnesium stearate and hydrosilicate, macrogol 6000, hypromellose, titanium dioxide.

Release form

Pharmacological forms of the drug:

• biconvex oval pills in a white film shell with a shiny smooth surface (10 pieces in blisters made of aluminum foil and PVC, 5 blisters per package);
• transparent, Brown solution for oral administration with a pronounced caramel smell (in ampoules of 10 ml, 10 ampoules in a cardboard packaging insert);
• white oval biconvex pills in a film shell (15 pieces in blisters made of aluminum foil and PVC-PE-PVDC, 2 or 4 blisters per package).

pharmachologic effect

Pharmacotherapeutic group: B vitamins in combination with minerals. The action of the drug is aimed at replenishing magnesium deficiency.

Pharmacodynamics and pharmacokinetics

Magnesium (Mg) - this is an important biogenic element, which is present in significant quantities in all tissues of the body, is a cofactor of most metabolic processes and ensures normal cell functioning.

In particular, this element is necessary for biotransformation creatine phosphate in ATP - nucleoside triphosphate, which plays the role of a universal energy supplier in living cells of the body.

Without magnesium it cannot be synthesized normally protein . The element takes part in muscle contraction (including maintaining normal function heart muscle ), regulates the transmission of impulses in nerve fibers , promotes expansion vessels , stimulates bile separation , increases motor activity intestinal tract , which in turn promotes excretion from the body.

Magnesium enters the body with food. Its deficiency may be primary (due to hereditary pathologies) or secondary. Secondary magnesium deficiency is usually associated with:

• with eating disorders (poor vitamins and minerals diet, exclusively parenteral nutrition, chronic alcoholism);
• with an increase in a person’s need for a microelement during intense physical or mental activity, during periods of intensive growth, during pregnancy, during stress, excessive losses of Mg through the kidneys (for example, with chronic , abuse diuretics , treatment);
• with impaired absorption of Mg in the gastrointestinal tract due to Gipoparathyroidism , chronic diarrhea etc..

Vitamin B6 (pyridoxine) improves the course of metabolic processes, including in brain tissue. As a result, brain performance increases, mood and memory improve.

Moreover, the presence pyridoxine as part of the drug Magne B 6 improves the absorption of Mg from digestive tract and its distribution in the cells of the body.

If the serum concentration of Mg is in the range from 12 to 17 mg/l, they speak of moderate Mg deficiency. An indicator not exceeding 12 mg/l is evidence of severe microelement deficiency.

IN digestive tract no more than half of the Mg dose taken orally is absorbed. 99% of the trace element is located in the intracellular space, while about 66% of intracellular Mg is distributed in bone tissue , the remaining amount is in striated and smooth muscles .

Mg is excreted mainly in the urine (about a third of the dose taken).

Indications for use

Indications for use of the drug Magne B6 are: confirmed Mg deficiency (both isolated and associated with others deficiency states).

Symptoms of the fact that Mg enters the body in insufficient quantities are increased fatigue and irritability, sleep disturbances, rapid heartbeat, stomach and intestinal cramps, tingling sensation in the muscles, as well as spasticity and soreness.

Contraindications

Contraindications to the use of Magne b6 are:

• severe renal failure (conditions in which clearance does not exceed 30 ml per minute);
• impaired absorption of glucose and galactose , fructose intolerance, sucrose-isomaltase deficiency (only for the tablet form of the drug);
• simultaneous administration antiparkinsonian drug ;
• hypersensitivity to the substances contained in the tablets/solution.

In pediatrics, tablet forms of the drug are prescribed from the age of six; the solution in ampoules is allowed from the age of one.

Due to the risk of developing hypermagnesemia the drug should be prescribed with caution to persons with moderate degrees of renal failure .

Side effects

The drug very rarely causes side effects. Allergic (including skin) reactions are possible in no more than 0.01% of cases.

Sometimes taking Magne B 6 is accompanied by side effects from digestive tract (flatulence, abdominal pain, diarrhea, nausea, vomiting), however, it is impossible to determine the frequency of their occurrence based on currently available data.

Instructions for Magna B6

Before taking Magne B6, you should consult your doctor. Average duration course - one month. Treatment is stopped immediately after the Mg concentration in the blood is normalized.

The medicine is taken with meals 2 or 3 times a day.

If the drug is prescribed during pregnancy, the dose is selected individually by the attending physician.

Magne B6 tablets: instructions for use

Magne b6 tablets are taken 6-8 pieces per day.

According to the instructions for use for children, the daily dose for patients over 6 years of age (provided that their body weight exceeds 20 kg) is 4 to 6 tablets.

Instructions for Magne B6 in ampoules

Adults are prescribed the solution to take 3-4 ampoules of 10 ml per day. Before administration, the drug is dissolved in 0.5 glasses of drinking water.

For children over 12 months (if their body weight exceeds 10 kg), Magne B6 in ampoules is prescribed to take 10-30 mg of Mg per kilogram of weight (the indicated dose is contained in 1-4 ampoules of the drug).

Instructions for Magne B6 Premium

The tablets are taken with meals. Swallow them whole with a glass of drinking water.

For an adult, the daily dose of Magne B 6 is 3-4 tablets. Children over six years of age (if their weight exceeds 20 kg) should be given 10 to 30 mg/kg/day. (or 2-4 tablets).

Overdose

In patients with normally functioning kidneys, an overdose of magnesium taken orally does not usually cause toxic reactions. At renal failure Excess magnesium can cause poisoning, the symptoms of which are:

• nausea;
• vomit;
• ECG changes;
• decrease in blood pressure;
• hyporeflexia ;
• CNS depression;
• cardiorespiratory dysfunction (up to coma, respiratory paralysis and cardiac arrest);
• anuric syndrome .

The severity of overdose symptoms depends on the concentration of the trace element in the blood.

Treatment involves forced diuresis and purpose rehydration therapy . At renal failure shown peritoneal dialysis And .

Interaction

Due to pyridoxine (in any quantity) inhibits activity levodopa , it is contraindicated to prescribe this drug in combination with Magne B6. This applies to situations where the reception levodopa is not combined with taking drugs that suppress the activity of peripheral decarboxylase of aromatic amino acids existing in the L-form.

Since Mg preparations reduce absorption tetracyclines , between taking them you should maintain at least a three-hour interval.

Terms of sale

Over the counter.

Storage conditions

Magne B6 No. 50: in a place protected from moisture and light, out of reach of children, where the temperature is maintained at up to 25 degrees Celsius.

Solution: in a place protected from light at temperatures up to 25 degrees Celsius.

Magne B6 Forte: at temperatures up to 30 degrees Celsius. Keep away from children.

Best before date

The tablets are usable for 24 months and the solution for 36 months after the date of manufacture.

special instructions

Ampoules with Magne B6 solution are self-breaking (each has 2 marking rings and a break line) and does not require the use of a nail file.

To open the ampoule, take it by the tip, having previously covered it with a piece of fabric, and with a sharp movement break it off first from the pointed end, then from the opposite. The end opened first is directed at an angle into a cup of water so that the tip of the ampoule, which is broken off second, is not above the cup.

After the second tip of the ampoule is broken off, the solution will flow freely into the glass.

Patients with need to remember that film-coated tablets contain sucrose as an excipient. Therefore, the dosage form that is more preferable for them is a solution that does not contain sugar.

At malabsorption syndrome (poor absorption) and severe magnesium deficiency treatment should begin with intravenous administration of Mg preparations.

If the patient has a concomitant calcium deficiency, Mg deficiency is corrected before starting treatment food additives or drugs containing Ca.

The solution contains sulfite, a substance that can cause or intensify hypersensitivity reactions, including anaphylactic type reactions (especially in patients at risk).

Taking high (exceeding 200 mg/day) doses pyridoxine within a few months/years may cause the development sensory axonal polyneuropathy , which is manifested by symptoms such as tremor, numbness and disorders of proprioceptive sensitivity of the distal parts of the arms and legs, gradually manifesting sensory ataxia (impaired balance).

Disorders of this kind are usually reversible and disappear after stopping taking vitamins.

Analogues of Magne B6

Level 4 ATX code matches:

Analogues of Magne B6 are drugs Magnesium B6 Evalar , Magnelis B6 , , Magnistad , AT 6 , Beresh Magnesium plus B6 .

The price of analogue tablets is from 150 Russian rubles.

Which is better: Magnelis or Magne B6?

A drug Magnelis B6 is produced by Pharmstandard and, like its analog Magne B6, is intended to replenish Mg deficiency in organism. The products have a similar composition (Magnelis contains 470 mg of Mg lactate and 5 mg pyridoxine , in Magna B6 - 470 mg Mg lactate dihydrate and 5 mg pyridoxine ), same readings for use and contraindications, cause similar side effects.

The main differences are the manufacturer and price.

Magne B6 for children

Magnesium is very important for children because it participates in various biochemical reactions of the body, improves the absorption of calcium and the tone of the walls of blood vessels, and normalizes the conduction of nerve impulses in the brain.

Magnesium deficiency is very closely related to stress. Experts consider Mg deficiency and stress to be interdependent processes that can aggravate each other.

AND spicy , And chronic stress lead to depletion of the intracellular Mg pool and its loss in the urine. This is due to the fact that in stressful situation the body secretes large quantity and, which promote the elimination of Mg from cells.

Magnesium deficiency often leads to decreased ability to concentrate, memory impairment, seizures , disturbance of consciousness and coordination sphere (usually this manifests itself in the form nystagmus, ataxia, tremor ). Some children develop paresthesia and rise tendon reflexes .

In children of all ages, Mg deficiency (as well as stress) provokes an increase in - one of the significant components of stress and changes the cerebroreactive reactivity of blood vessels towards a constrictor response.

Biochemical and clinical-neuropsychological studies, as well as reviews of Magne B6 for children, confirm that taking Mg drugs can curb the rise in blood pressure, increase stress resistance, improve behavior, memory and attention, normalize sleep, reduce anxiety, synkinesis and aggression.

In accordance with the instructions, in pediatric practice the solution is prescribed from the age of one year, tablets - after 6 years, however, if there is neurological disorders Magne B6 can be used from the first days of life. The dosage for an infant is calculated depending on his body weight.

It is very important that the composition of the drug (both in the form of a solution and in the form of tablets) includes organic Mg salts - lactate, citrate and pidolate - which are characterized by high bioavailability and practically do not cause side effects.

Magne B6 Forte, which is based on Mg citrate, is recommended for use in children with oxalaturia and acidosis , as well as in children with a lateral shift: the drug is used to compensate for rapid nervous and mental exhaustion in patients with neuroarthritic type of constitution and for prevention urolithiasis .

Magne B6 during pregnancy

Why Magne B6 during pregnancy?

Magne b6 is prescribed quite often during pregnancy. It is advisable to use the drug in pregnant women when:

• threatening spontaneous miscarriage hypertonicity of the uterine muscles ;
• confirmed by test results Mg deficiency in organism.

Clinical experience the use of Mg preparations and doctors’ reviews of Magne B6 indicate that the prescription of the drug for hypertonicity of the uterus allows you to quickly and effectively calm the nervous system, as well as relieve spasms and tension in the muscles.

The main reason for the increased tone of the uterine muscles is the calcium contained in the muscle fibers. Mg has the ability to reduce its amount and thereby promote muscle relaxation.

During the period of bearing a child female body more magnesium is required than usual. If the microelement is not supplied to it from the outside in the required doses, the fetus begins to draw Mg from the mother’s body, which significantly affects the health and well-being of the pregnant woman. Once the mother's Mg reserves are depleted, the condition of the fetus will also begin to deteriorate.

Magnesium deficiency causes poor development of blood vessels in the placenta, which leads to malnutrition of the fetus and the threat of miscarriage.

Contraindications

The instructions for the drug indicate that contraindications for its use are fructose intolerance , severe renal failure , allergic reactions to the substances contained in the tablets/solution.

How to take MagneB6 during pregnancy?

The dosage of Magne B6 during pregnancy is usually as follows: 2 tablets with each of the main meals (morning, lunch and evening). Thus, the dose of Magne B 6 for a pregnant woman is 6 tablets per day, and the dosage regimen does not change depending on the stage of pregnancy.

In the 1st and 2nd trimesters, the use of the drug is advisable if there is a threat of miscarriage. In the third trimester, a woman usually experiences an increased feeling of discomfort, night cramps and swelling.

Magnesium deficiency can lead to increased secretion aldosterone and the development of edema. Delayed excretion of fluid from the body, in turn, provokes increased blood pressure , which is very dangerous both during pregnancy and during childbirth.

The duration of treatment can range from 2 weeks to 9 months. After childbirth, the drug is stopped, since it tends to penetrate into the milk of a nursing woman.

Magne B6 for children- a magnesium preparation, which includes Magnesium lactate dehydrate and Pyridoxine hydrochloride. Magnesium in a child’s body is found in all tissues and takes part in many metabolic reactions (including the transmission of nerve impulses and muscle function); without this microelement, cells cannot function normally.

Magnesium enters the child's body with food. With poor nutrition, increased mental or physical stress, or a stressful situation, there is a lack of magnesium in the body. Pyridoxine hydrochloride is necessary for the absorption of magnesium in the digestive tract, in addition, vitamin B6 is also needed for the normal functioning of the nervous system.

Magne B6 dosage: how to take magne B6 for children

Magne B6 is prescribed when a deficiency of magnesium is detected in the child’s body. Magnesium deficiency is manifested by insomnia, irritability, increased fatigue, tachycardia, pain, tingling and cramps in muscle tissue.

Magne B6 is not used:

• with increased sensitivity to it;
• phenylketonuria;
• acute renal failure;
• in conditions accompanied by fructose intolerance, impaired absorption of galactose and/or glucose, maltose deficiency;
• in children under 1 year of age.

Magne v6 for children under one year old cannot be given.

Magne B6 requires medical prescription, the dose is selected individually and depends on the level of magnesium deficiency and the age of the child:

Children over 1 year old, weighing more than 10 kg, are given 10 - 30 mg per 1 kg of body weight (that is, 1 - 3 ampoules) per day, divided into 2 - 4 doses.
. Children over 6 years old and weighing more than 20 kg are given 1 - 2 tablets of the drug 3 times a day.

The medicine is taken during meals, the tablets are washed down with plenty of water (200 ml), and the solution is diluted in 100 ml of water before use. The duration of treatment usually lasts 30 days or until the level of magnesium in the body returns to normal.

Contraindications for Magne B6 for children

When taking Magne B6, allergies may develop, as well as dyspeptic disorders (nausea, vomiting, epigastric pain), bloating and constipation, therefore Magne B6 for infant It is not recommended to give.

Cases of drug overdose when taken orally in healthy children have not been described. Toxic effect the drug may occur in case of renal failure, which is manifested by nausea, vomiting; hypotension, lethargy, impairment heart rate and breathing; anuria; in particular severe cases Possible cardiac arrest, coma. Urgently consult a doctor for hydration therapy, forced diuresis, hemodialysis.

Calcium preparations, as well as those containing phosphates, reduce the absorption of magnesium in the digestive tract, so such preparations are taken with an interval between doses sufficient for the excretion of magnesium. Magne B6 reduces the absorption of iron and thrombolytics.

The tablet shell contains sucrose, so for the treatment of children with diabetes mellitus it is necessary to give preference to a solution.

Medicines from any group should be used only on the recommendation of a doctor. Complaints about the ineffectiveness or harmful effects of drugs often arise due to their improper use. For example, magnesium B6: instructions for use of these tablets prescribe taking an average of 4 per day. But the doctor may suspect a patient has a magnesium deficiency or take into account the fact of pregnancy. In this case, for effectiveness, the dose must be doubled. The doctor will recommend stopping taking the pills if there are contraindications and will recommend an adequate replacement.

What is magnesium B6, why do you need to take it?

The drug, intended to replenish the lack of magnesium in the body, consists of two active ingredients - magnesium and pyridoxine (vitamin B6), supplemented with stabilizing components. Available in the form of tablets and solution for oral use.

The tablets contain about 50 mg of magnesium, and the solution in glass ampoules contains 100 mg. Accordingly, pyridoxine is 5 mg in tablets and 10 mg in ampoules.

Why does the body need magnesium?

Mg is an important substance for the body; more than a third of metabolic processes cannot occur without its participation. The reserve of magnesium in the body is 20-30 g, the main depot is bones and teeth, one percent is in the blood, the rest is distributed in muscles and other tissues.

Magnesium levels have the greatest impact on the heart muscle. Without it, the immune system suffers:

• antibody production is disrupted;
• heart rhythm and blood pressure are disturbed;
• stress vulnerability increases and disruption of the nervous system begins;
• the risk of developing diabetes mellitus and its complications increases;
• Calcium is not absorbed, so the condition of the skeletal system suffers, and dental health deteriorates;
• protein synthesis and many metabolic processes are disrupted.

What are the benefits of vitamin B6

It takes part in many vital processes:

• normalizes blood lipid balance, cholesterol levels, reducing the risk of stroke, heart attack, atherosclerosis;
• regulates blood pressure;
• improves the contractility of the heart muscle;
• necessary for the processes of protein metabolism and the creation of red blood cells;
• improves memory and brain function;
• contributes to the prevention of cancer pathology;
• stimulates the immune system, increases the production of antibodies;
• improves hair health.

Indications for use of the drug

The inclusion of these two components in the composition of the drug is due not only to their beneficial effects on the heart, blood vessels and nervous system, but also to their mutual reinforcing effect.

Magnesium B6 intake is indicated for the following conditions:

• cardiovascular disorders;
• hypertension;
• heart failure;
• arrhythmias;
• atherosclerosis;
• ischemic disease;
• cholesterolemia;
• increased blood clotting.
• pathologies of the nervous system;
• sleep disorders;
• irritability;
• depressive states;
• nervous tics;
• vegetative-vascular dystonia.

Magnesium B6: what is it needed for during pregnancy

During pregnancy, the need for magnesium increases threefold. If a woman usually needs 300 mg of magnesium per day, then the pregnancy period requires 925 mg, and the lactation period requires 1250 mg.

Doctors recommend saturating the expectant mother’s body with magnesium even before pregnancy, at the planning stage. Women are explained which magnesium-rich foods they should eat more of. And the drug magnesium B6 is prescribed to strengthen the mother’s nervous and vascular systems, preparing them for a period of increased stress.

Taking magnesium B6 during pregnancy provides:

• reduction of excitation in the nervous system;
• prevention of muscle convulsions, tics, painful spasms;
• prevention of spontaneous abortions, as it helps reduce uterine tone;
• reducing the risk of malformations of the nervous and vascular system in a child, thanks to the properties of pyridoxine.

The use of any medications during pregnancy, including magnesium B6, must be agreed with your doctor.

The drug is indicated for use in adults and children. The dosage and duration of use is determined by the attending doctor. The drug is usually well tolerated, but taking magnesium B6 can cause side effects such as

• nausea, vomiting;
• increased gas formation in the intestines;
• diarrhea or constipation;
• allergic reactions;
• stomach ache;
• paresthesia, numbness, neuropathic phenomena.

Similar effects may accompany long-term use of the drug in high dosages.

The dose and duration of administration are determined by the degree of magnesium deficiency, according to laboratory tests. Since magnesium is slowly accumulated by the body, the course of treatment is usually at least a month or two.

How to take magnesium B6 tablets

The daily dose of tablets, which averages 6-10 for adults and 4-6 for children, is divided into several doses per day.

Take with food.

The tablets are swallowed whole without chewing.

Take with a glass of water; other liquid is not recommended.

How to take magnesium B6 in ampoules

It is worth remembering that the ampoules contain 100 mg of magnesium, and take this into account when dosing. This form of the drug is convenient for use in children and weakened bedridden patients, in people with impaired intake of solid food.

For children from one to six years old, the dose is individually calculated - 10-30 mg of magnesium per 1 kg of body weight. This usually amounts to 1-4 ampoules per day. The drug is not prescribed for children weighing less than 10 kg.

Children 6-12 years old take magnesium B6 ampoules 1-3 per day.

After the age of twelve, the daily dose can be 2-4 ampoules.

Having broken the tip of the ampoule, its contents are poured into a glass and mixed with 100 ml of water. Use immediately; the solution cannot be stored.

When not to take magnesium B6 - contraindications

The main contraindications include:

• renal failure;
• simultaneous use with Levodopa;
• phenylketonuria;
• intolerance to components;
• less than a year old.
• the drug in tablet form is not given to children under six years of age;
• patients with glucose-galactose malabsorption syndrome;
• with fructose intolerance;
• with a lack of enzymes that break down sugars.

Magnesium B6 - analogues

Medicines with similar composition and action:

• Magnelis B6 (Russia);
• Magnefar and Magwit B6 (Poland);
• Beres plus (Hungary);
• Magnikum (Ukraine);
• Magnesium B6 Evalar;
• Magnesium plus B6.

Substitution can only take place after approval by the attending physician.

pro-varikoz.com

Magne-B6 for nervous system health

Magnesium B6 vitamins are used to treat disorders of the nervous system associated with a lack of compounds in the body. The drug is prescribed for anxiety attacks, muscle pain, sleep disturbances, and excessive fatigue. It is accompanied by detailed instructions that describe the pharmaceutical properties, indications, contraindications and other features.

What does Magne-B6 consist of?

The drug is available in tablets and ampoules for oral administration. Pharmacological action is due to chemical composition.

Magnesium is found in every cell of the body. It regulates metabolic processes. Another main function is the regulation of the transmission of nerve impulses. Magnesium enters the body with food. Certain factors, such as low-calorie or poor nutrition, contribute to the development of deficiency.

Deficiency may also be due to poor absorption in the intestine or excessive excretion. Additional amounts of magnesium are necessary during pregnancy, physical and mental labor.

Depending on the degree of deficiency, a certain dose of Magne-B6 is prescribed. Pyridoxine acts as a coenzyme. It takes part in metabolism, including the regulation of metabolism occurring in the tissues of the nervous system. Pyridoxine is able to improve the absorption of magnesium in the intestine, retain it in cells, thereby preventing increased excretion.

After taking the tablet orally in small intestine About 50% of magnesium is absorbed. The third part is distributed in bone tissue. The other two lobes are inside the cells and muscles. After filtration in the kidneys, the element is reabsorbed in the renal tubules. 30% is excreted in the urine.

During biochemical reactions, pyridoxine is converted into pyridoxal phosphate. In this form the compound exhibits maximum activity.

When is Magne-B6 prescribed?

Instructions for use include information about indications:

• inadequate sleep;
• increased irritability and others nervous disorders;
• a state of asthenia, increased mental or physical stress, accompanied by excessive fatigue;
• muscle spasm and soreness;
• gastrointestinal cramps;
• tingling feeling in the body;
• heartbeat disturbance;
• anxiety attacks.

Taking the drug helps compensate for the deficiency of magnesium and pyridoxine.

Mode of application

The tablets are taken with food. They must be washed down with enough water. The recommended daily dose is divided into several doses. The solution in ampoules is diluted in 100 ml of water.

Vitamins are intended for adults. Children can take the drug from 6 years of age. In younger children, it is recommended to take Magne-B6 in the form of a solution.

The instructions describe the dosage in detail:

1. Adults and children over 12 years old. The daily dose for obvious magnesium deficiency is 6-8 tablets or 3-4 ampoules, for spasmophilia - 4-6 tablets, which can be replaced with 2-3 ampoules.
2. Children over 1 year old. If body weight is more than 10 kg, Magne-B6 is prescribed at the rate of 10-30 30 mg/kg/day. At the age of 6-12 years – 2-6 tablets or 1-3 ampoules, depending on age and health condition.

The use of the drug should be stopped immediately after normalization of magnesium levels in the blood. The recommended course of treatment is 1 month. To open ampoules of the drug, you do not need to use special files. The tip, covered with a piece of cloth, breaks off with a sharp movement.

About contraindications, overdose, side effects

If the instructions are followed, the occurrence of an overdose is reduced to zero.

It is better to refrain from taking Magne-B6 in following cases:

• intolerance or hypersensitivity to the components included in the drug;
• severe renal failure;
• phenylketonuria;
• for tablets: childhood up to 6 years;
• for solution: age up to 1 year;
• fructose intolerance or impaired glucose absorption.

Magne-B6 is used with caution in moderate renal failure. During pregnancy, the drug is used strictly as prescribed by the doctor. During breastfeeding, taking pills is not advisable, since magnesium is released with mother's milk.

With normal kidney function, taking Magne-B6 orally does not cause toxic effects.

But if the instructions are violated and the tablets are taken for renal failure, toxic reactions are possible, manifested by symptoms:

• slow reflexes;
• nausea and vomiting;
• decreased blood pressure, depression;
• oppression respiratory function, cardiac arrest, coma, cardiac paralysis.

Depending on the symptoms, treatment is prescribed.

Side effects:

• indigestion: nausea, vomiting, increased gas formation, constipation, rarely - diarrhea;
• peripheral neuropathy in in rare cases with long-term use of the drug;
• allergic reactions.

What should you pay attention to?

Before use, it is advisable to consult a doctor!

1. Magne-B6 is prescribed with caution in case of impaired renal function due to the high risk of developing hypermagnesemia. With simultaneous calcium deficiency, magnesium deficiency must be eliminated before treatment with drugs containing calcium is started. Therapy begins with parenteral administration of magnesium sulfate.

2. If you have diabetes, it should be taken into account that Magne-B6 contains sucrose as an excipient.

3. When using laxatives, alcohol abuse, increased physical and mental stress, the need for the element increases. As a result, the risk of failure increases.

4. If the drug does not help eliminate symptoms such as constant feeling fatigue, irritability, insomnia, you should consult a doctor. In patients prone to allergies, the likelihood of reactions when taking the solution orally increases, including anaphylactic shock.

5. Magne-B6 does not affect control ability complex mechanisms and road transport.

How do the components of the drug interact with other substances?

A slight decrease in magnesium absorption is possible with simultaneous use of drugs that contain calcium salts and phosphates. Magne-B6 helps reduce the effectiveness of tetracycline antibiotics. The interval when using them together should be at least 3 hours.

Magnesium reduces the effects oral anticoagulants. The absorption of iron is impaired.

Pyridoxine neutralizes healing effect antiparkinsonian effect of levodopa.

It is recommended to store the drug in a dry place, protected from sunlight. The optimal temperature is less than 25°C. Do not use after the expiration date of 2 years. Magne-B6 does not require a prescription when dispensed from a pharmacy. Instructions are included with each package.

The drug Magne-B6 is very often prescribed to adults, children, and pregnant women. It is able to neutralize threats of abortion. To do this, a woman must take other vitamins.

The element magnesium takes part in all vital biochemical transformations. This explains its importance for the body.

Magne-B6 – reliable means against cramps. Any nervous disorders are eliminated by exposure to the components of the drug.

Vitamin B 6Vitamin B12 instructions for use

vitaminodin.ru

Magne B6 - official instructions for use

Analogs, articles Comments

Registration number:

P N013203/01, P N013203/02.

Trade name of the drug:

Magne B6®.

Dosage form:

film-coated tablets, oral solution.

Compound

Film-coated tablets Tablet core: active ingredients: magnesium lactate dihydrate* - 470 mg; pyridoxine hydrochloride - 5 mg;

excipients: sucrose - 115.6 mg, heavy kaolin - 40.0 mg, acacia gum - 20.0 mg, carboxypolymethylene 934 - 10.0 mg, talc (magnesium hydrosilicate) - 42.7 mg, magnesium stearate - 6, 7 mg.

Tablet shell: acacia gum - 3.615 mg, sucrose - 214.969 mg, titanium dioxide - 1.416 mg, talc (magnesium hydrosilicate) - traces, carnauba wax (powder) - traces. * - equivalent to magnesium content (Mg++) 48 mg

Oral solution Active ingredients: magnesium lactate dihydrate** - 186 mg; magnesium pidolate** - 936 mg; pyridoxine hydrochloride - 10 mg;

excipients: sodium disulfite - 15 mg, sodium saccharinate - 15 mg, cherry-caramel flavoring - 0.3 ml, purified water up to 10 ml.

** - equivalent to total magnesium content (Mg++) 100 mg

Description Film-coated tablets: oval, biconvex, white film-coated tablets with a smooth, shiny surface. Oral solution: clear, brown liquid with a caramel odor.

Pharmacotherapeutic group

Magnesium preparation.

ATX code: A11JB.

Pharmacological properties

Pharmacodynamics Magnesium is vital important element, which is found in all tissues of the body and is necessary for the normal functioning of cells, is involved in most metabolic reactions. In particular, it is involved in the regulation of the transmission of nerve impulses and muscle contraction. The body receives magnesium through food. A lack of magnesium in the body can occur when the diet is disrupted or when the need for magnesium increases (with increased physical and mental stress, stress, pregnancy, use of diuretics). Pyridoxine (vitamin B6) is involved in many metabolic processes and in the regulation of nervous system metabolism. Vitamin B6 improves the absorption of magnesium from the gastrointestinal tract and its penetration into cells. Serum magnesium content:

from 12 to 17 mg/l (0.5 – 0.7 mmol/l) indicates moderate magnesium deficiency;

below 12 mg/l (0.5 mmol/l) indicates severe magnesium deficiency. Pharmacokinetics Absorption of magnesium in the gastrointestinal tract is no more than 50% of the dose taken orally. 99% of magnesium in the body is found inside cells. Approximately 2/3 of intracellular magnesium is distributed in bone tissue, and the other 1/3 is in smooth and striated muscle tissue. Magnesium is excreted primarily in the urine. At least 1/3 of the dose of magnesium taken is excreted in the urine. Established magnesium deficiency, isolated or associated with other deficiency conditions, accompanied by symptoms such as: increased irritability, minor sleep disturbances; gastrointestinal cramps or rapid heartbeat; increased fatigue, pain and muscle spasms, tingling sensation.

Hypersensitivity to the components of the drug.

Severe renal failure (creatinine clearance less than 30 ml/minute).

Phenylketonuria.

Children's age up to 6 years (for the drug in tablet form) and up to 1 year (for solution).

Fructose intolerance, glucose-galactose malabsorption syndrome, sucrase-isomaltase deficiency (only for the drug in tablet form due to the presence of sucrose in the composition).

Concomitant use of levodopa (see section "Interaction with other medicines»).

With caution moderate degree renal failure, as there is a risk of developing hypermagnesemia.

Use during pregnancy and lactation

Pregnancy Clinical experience with the use of the drug in a sufficient number of pregnant women has not revealed any adverse effects on the occurrence of fetal malformations or fetotoxic effects.

Magne B6® can be used during pregnancy only if necessary, on the recommendation of a doctor.

Breastfeeding Period Magnesium passes into breast milk. The use of the drug should be avoided during lactation and breastfeeding. Before taking the drug, you should consult your doctor. Film-coated tablets Adults are recommended to take 6-8 tablets per day. Children over 6 years old (body weight more than 20 kg) 4-6 tablets per day.

Oral solution

Adults are recommended to take 3-4 ampoules per day. For children over 1 year old (body weight more than 10 kg), the daily dose is 10-30 mg magnesium/kg body weight (0.4 - 1.2 mmol magnesium/kg) or 1-4 ampoules. The daily dose should be divided into 2-3 doses, taken with meals. The tablets should be taken with a glass of water. The solution from the ampoules is dissolved in? glasses of water.

Treatment should be stopped immediately after normalization of magnesium concentration in the blood.

Attention Self-breaking ampoules with Magne B6® do not require the use of a nail file. To open the ampoule, take it by the tip, having previously covered it with a piece of cloth, and break it off with a sharp movement, first from one pointed end, and then from the other, having previously directed open first the end of the ampoule at an angle into a glass of water, so that the tip of the ampoule that is broken off by the second is not above the glass. After breaking off the second tip of the ampoule, its contents will flow freely into the glass.

Side effect

Immune system disorders Very rare (Gastrointestinal disorders Unknown frequency (it is not possible to estimate the frequency of occurrence based on available data): diarrhea, abdominal pain, nausea, vomiting, flatulence.

Overdose

Symptoms With normal kidney function, an overdose of magnesium when taken orally usually does not lead to toxic reactions. However, in case of renal failure, magnesium poisoning may develop. Symptoms of overdose, the severity of which depends on the concentration of magnesium in the blood: decreased blood pressure; nausea, vomiting; depression of the central nervous system, decreased reflexes; changes in the electrocardiogram; respiratory depression, coma, cardiac arrest and respiratory paralysis; anuric syndrome.

Rehydration, forced diuresis. In case of renal failure, hemodialysis or peritoneal dialysis is necessary.

Interaction with other drugs

Contraindicated combinations

With levodopa: the activity of levodopa is inhibited by pyridoxine (unless this drug is combined with the use of peripheral aromatic L-amino acid decarboxylase inhibitors). Any amount of pyridoxine should be avoided unless levodopa is taken in combination with peripheral aromatic L-amino acid decarboxylase inhibitors. Combinations not recommended

The simultaneous use of drugs containing phosphates or calcium salts may impair the absorption of magnesium in the intestine. Combinations to Consider

When prescribing tetracyclines orally, it is necessary to maintain an interval of at least three hours between ingestion of tetracycline and Magne B6®, since magnesium preparations reduce the absorption of tetracyclines. Information for patients with diabetes mellitus: film-coated tablets contain sucrose as an excipient. In case of severe magnesium deficiency or malabsorption syndrome, treatment begins with intravenous administration of magnesium preparations. In case of concomitant calcium deficiency, it is recommended to correct the magnesium deficiency before taking calcium supplements or dietary supplements containing calcium. At frequent use laxatives, alcohol, intense physical and mental stress, the need for magnesium increases, which can lead to the development of magnesium deficiency in the body. Ampoules contain sulfite, which may cause or intensify reactions. allergic type, including anaphylactic reactions, especially in patients at risk.

When using pyridoxine in high doses(more than 200 mg per day) over a long period of time (over several months or in some cases years), sensory axonal neuropathy may develop, which is accompanied by symptoms such as numbness, impaired proprioceptive sensitivity, tremor of the distal limbs and gradually developing sensory ataxia (impaired coordination of movements). These disorders are usually reversible and disappear after stopping vitamin B6.

The drug in tablet form is intended only for adults and children over 6 years of age. For children younger age(over 1 year) the drug is recommended in the form of an oral solution. Impact on ability to drive and potentially engage in other activities dangerous species activities No effect. Special recommendations No. Film-coated tablets 10 tablets in a blister made of PVC/aluminum foil. 5 blisters along with instructions for use are placed in a cardboard box.

Oral solution

10 ml of the drug in dark glass ampoules (hydrolytic class III EF), sealed on both sides, with a break line and two marking rings on each side. 10 ampoules in a cardboard packaging insert along with instructions for use are placed in a cardboard box. Film-coated tablets: 2 years. Oral solution: 3 years. The drug should not be used after the expiration date. Film-coated tablets: in a dry place, protected from light, at a temperature not exceeding 25? C. Solution for oral administration: in a place protected from light at a temperature not exceeding 25? C. Keep out of the reach of children. Available without a prescription. Film-coated tablets Sanofi Winthrop Industry. 82, Avenue Raspail, 94250 Gentilly - France.

Oral solution Sanofi Winthrop Industry. 82, Avenue Raspail, 94250 Gentilly, France. Cooperation Pharmaceutical Française. Place Lucien Auvers 77020 Melan, France. Consumer complaints should be sent to:

125009, Moscow, st. Tverskaya, 22.

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Instructions for use Magnesium B6: what is it for, analogues

Magnesium B6 is a medicine intended to replenish the deficiency of magnesium and vitamin B6 in the body and eliminate disorders caused by a lack of these substances. Everyone knows that our health directly depends on sufficient provision of the body with vitamins and microelements. But not always everything necessary substances can be obtained with food. They come to the rescue vitamin complexes and biologically active additives, replenishing the deficiency of essential minerals. One of these drugs is Magnesium B6.

Benefits of Magnesium B6 for the body

The role of magnesium in the body cannot be overestimated; it is this microelement that helps maintain the normal functioning of vital important organs- heart, liver, kidneys, musculoskeletal apparatus. Its deficiency immediately affects general health and provokes sleep disorders, attacks of weakness, muscle pain, increased nervous excitability and anxiety, and leads to mental and physical fatigue.

The daily requirement for magnesium is as follows:

• for women - 300 mcg;
• for men - 350 mg;
• for children - from 150 to 200 mg.

Separately, it is necessary to highlight the category of pregnant and lactating women. During the period of bearing a child daily requirement in magnesium it increases to 925 mg, and during lactation it reaches its maximum of -1250 mg.

What is Magnesium B6 needed for and what role do the elements on which this drug is based play in the body?

We list the main functions of magnesium in the body:

1. this substance is involved in protein synthesis;
2. activates the processes of regeneration and cell renewal;
3. helps eliminate toxins, allergens and other harmful substances;
4. has a beneficial effect on the functioning of the nervous system;
5. normalizes blood cholesterol levels;
6. participates in phosphorus metabolism;
7. supports the functioning of the heart muscle;
8. serves as a prevention of urolithiasis.

It is magnesium that controls the transmission of nerve impulses, prevents the development of atherosclerosis, normalizes metabolism, and relieves nervous tension. This is the main microelement necessary for the smooth and stable functioning of the heart, therefore drugs containing it are prescribed for heart failure. vascular diseases, and also when arterial hypertension.

Vitamin B6 included in the preparation is a successful addition. It strengthens therapeutic effect magnesium, improves its absorption from the digestive system and accelerates penetration into tissues and cells. In addition, vitamin B6 also normalizes the functions of the nervous system, strengthens blood vessels and supports heart function.

Magnesium B6: release forms

Today the drug is available in three dosage forms:

• Magne B6 tablets. Exist different variants packaging - 30 and 50 tablets. Each of them contains 470 mg of magnesium lactate + excipients. Biconvex tablets, white film coated, oval shape.
• Additionally, Magnesium B6 Forte tablets are produced, the composition of which is slightly different. They are based on magnesium citrate, pyridoxine + excipients. The drug is packaged in 15 pieces in aluminum blisters. The pack may contain 2 or 4 blisters of tablets.
• Oral solution in ampoules of 10 ml - a clear brown liquid with a caramel odor. The contents of one ampoule are equivalent to 10 mg of magnesium. Ampoules of 10 pieces are packaged in cardboard inserts and placed in packs.

When is Magnesium B6 prescribed?

The main indication for use of the drug is laboratory-confirmed magnesium deficiency. The reason for contacting a doctor should be anxiety states, indicating a deficiency of this element - increased nervousness, high fatigue, insomnia, painful sensations and tingling in the heart area, heart rhythm disturbances, muscle pain or gastrointestinal cramps.

This drug is necessarily prescribed as part of complex therapy for heart failure, arrhythmia, high blood pressure, elevated cholesterol levels or a tendency to thrombosis. In the treatment of neurological pathologies, Magnesium B6 also becomes the drug of choice - a neurologist can prescribe it for the treatment of neuroses, depressive states, with sleep disorders or manifestations of vegetative-vascular dystonia.

Magnesium and pregnancy

Magnesium B6 during pregnancy protects the nervous system of the expectant mother and helps her bear the baby without problems. This element is necessary for the proper intrauterine development of the fetus; its deficiency increases the risk of developing hypoxia. A pregnant woman can obtain this element from food. For example, buckwheat and oatmeal, legumes, dried fruits. But if the amount of magnesium supplied from food is not enough, you will have to additionally take medications based on it. Magnesium B6 during pregnancy is prescribed for the following complaints:

• mood swings, irritability, insomnia, influence of stress factors;
• weakness, severe fatigue;
• severe toxicosis, threat of termination of pregnancy early;
• intestinal colic;
• convulsions calf muscles;
• numbness of the limbs, hair loss.

Magnesium is also prescribed in the last months of pregnancy if the fetus moves too intensely. This indicates oxygen starvation, and taking the most important microelement allows you to eliminate this problem and cope with hypoxia.

Magnesium B6 for children

For children, magnesium preparations are prescribed for elevated nervous excitability, propensity to neurotic reactions, sleep problems, unreasonable fears and anxiety. Such symptoms indicate a lack of an element in the body. In this case, parents are advised to bring the child for examination and, if the diagnosis is confirmed, start taking Magnesium B6 or its analogues.

Magnesium B6 Forte, which is based on magnesium citrate, is recommended for use in children with rapid mental and nervous exhaustion, as well as in children suffering from acidosis.

Contraindications

Like anyone else medicine, the drug with magnesium has a number of contraindications for use. Magnesium B6 should not be prescribed for the following conditions:

• severe renal failure;
• individual intolerance to the components of the drug;
• children's age (up to 6 years);
• fructose intolerance;
• glucose-galactose deficiency syndrome;
• phenylketonuria.

The drug is prescribed with extreme caution for moderate renal failure. Another limitation is the prohibition on the simultaneous use of Levopoda with magnesium preparations. An important clarification concerns the use of the drug in children. For children under 6 years of age, Magnesium B6 can be prescribed in the form of an oral solution, while taking the tablet form of the medication is prohibited.

Instructions for use

The doctor's consultation

Instructions for use Magnesium B6 prescribes taking the medicine during meals with a sufficient amount of liquid (at least 200 ml). Standard daily dosage for an adult - from 6 to 8 tablets, for a child (from 6 years old) - from 4 to 6 tablets. This dose is divided into two or three doses. If there is a lack of magnesium during pregnancy, up to 6 tablets per day are prescribed, for prevention purposes - 2 tablets per day.

Magnesium B6 solution is intended for oral administration. Before using it, break the tip of the ampoule, pour the solution into a cup and drink it during meals with a glass of water. The standard dose for adults per day is 3-4 ampoules, for children - 1-3 ampoules.

The optimal dose should be recommended by your doctor. individually, based on the results of laboratory tests confirming a lack of magnesium in the body. The duration of the course of therapy is also determined by the doctor; on average, the drug should be taken for a month.

Side effects

Taking Magnesium B6 may cause immune system side effects. They appear allergic reactions, skin rashes. Possible negative manifestations from the digestive system, which are accompanied by nausea, flatulence, stool upset, and abdominal pain. But they occur quite rarely and quickly disappear after discontinuation of the drug.

If while taking Magnesium B6 you experience alarming symptoms and your health worsens, you should immediately inform your doctor about this in order to decide on the possibility of its further use.

At normal operation an accidental overdose of magnesium is not dangerous for the kidneys. But with renal pathologies, toxic reactions develop, accompanied by vomiting, a drop in blood pressure, and respiratory depression. In severe cases, even cardiac arrest is possible. Therefore, before prescribing the drug, it is necessary to clarify whether the patient has contraindications for use and identify concomitant diseases.

Analogs and price

Among the analogues of Magnesium B6 are the following popular drugs:

• Magnelis B6;
• Magnicum;
• Magnefar B6;
• Magnesium B6 Evalar.

Analogues usually cost an order of magnitude cheaper and have some differences in composition.

The price of Magnesium B6 in pharmacies depends on the manufacturer, release form, and region of sale. On average, the cost of Magnesium B6 tablets (50 pcs) is 280 rubles, ampoules (10 pcs) - from 360 rubles. Despite the fact that this drug is available from pharmacies without a prescription, you should consult a doctor before purchasing and using it, since the use of the drug for some pathologies can lead to unpredictable consequences.

Magnesium preparation

Active ingredients

Release form, composition and packaging

◊ Oral solution as clear liquid brown color with a caramel smell.

Excipients: sodium disulfite - 15 mg, sodium saccharinate - 15 mg, cherry-caramel flavor - 0.3 ml, purified water - up to 10 ml.

10 ml - dark glass ampoules, sealed on both sides (10) - cardboard packaging inserts (1) - cardboard packs.

pharmachologic effect

Magnesium is a vital element that is found in all tissues of the body and is necessary for the normal functioning of cells and is involved in most metabolic reactions. In particular, it is involved in the regulation of the transmission of nerve impulses and muscle contraction.

The body receives magnesium through food. A lack of magnesium in the body can be observed when the diet is disrupted, when the need for magnesium increases, or when there is an imbalance in the intake, metabolism and excretion of magnesium (for example, with increased physical and mental stress, stress, during pregnancy, when using diuretics).

Overdose

With normal kidney function, an overdose of magnesium when taken orally usually does not lead to toxic reactions. However, in case of renal failure, magnesium poisoning may develop. The severity of symptoms depends on the concentration of magnesium in the blood.

Symptoms: decreased blood pressure, nausea, vomiting, central nervous system depression, decreased reflexes, ECG changes, respiratory depression, coma, cardiac arrest and respiratory paralysis, anuric syndrome.

Treatment: rehydration, forced diuresis. In case of renal failure, hemodialysis or peritoneal dialysis is necessary.

Drug interactions

Contraindicated combinations

With levodopa: the activity of levodopa (unless this drug is combined with peripheral aromatic L-amino acid decarboxylase inhibitors) is inhibited by pyridoxine. Any amount of pyridoxine should be avoided unless levodopa is taken in combination with peripheral aromatic L-amino acid decarboxylase inhibitors.

The simultaneous use of drugs containing phosphates or calcium salts may impair the absorption of magnesium in the intestine.

Combinations to Consider

When prescribing oral antibiotics, it is necessary to maintain an interval of at least 3 hours between oral administration of tetracycline and Magne B6, because Magnesium preparations reduce the absorption of tetracyclines.

special instructions

In case of severe magnesium deficiency or malabsorption syndrome, treatment begins with intravenous administration of magnesium preparations.

With frequent use of laxatives, alcohol, intense physical and mental stress, the need for magnesium increases, which can lead to the development of magnesium deficiency in the body.

The oral solution contains sulfite, which may cause or intensify allergic reactions, including anaphylactic reactions, especially in high-risk patients.

When using pyridoxine in high doses (more than 200 mg/day) for a long time (over several months or in some cases years), sensory axonal neuropathy may develop, which is accompanied by symptoms such as numbness, impaired proprioceptive sensitivity, distal tremor limbs and gradually developing sensory ataxia (impaired coordination of movements). These disorders are usually reversible and disappear after stopping vitamin B 6 intake.

Impact on the ability to drive vehicles and machinery

Pregnancy and lactation

Pregnancy

Clinical experience with the use of the drug in a sufficient number of pregnant women has not revealed any adverse effects on the occurrence of fetal malformations or fetotoxic effects.

Conditions for dispensing from pharmacies

The drug is available without a prescription.

Storage conditions and periods

The drug should be stored out of the reach of children, protected from light at a temperature not exceeding 25°C. Shelf life - 3 years.