What is Nimesil prescribed for? Nimesil drug: instructions for use, how to dilute the powder and how to take a suspension to suppress destructive processes in diseases of the musculoskeletal system
Pain may accompany inflammatory process, bring significant discomfort and cause complications. Helps determine treatment experienced specialist, among the prescribed drugs, Nimesil powder is often prescribed. We will describe in detail how to drink Nimesil in powder, but we note that it is not recommended to take medicines without a doctor's prescription.
About the drug
Nimesil is a non-steroidal sulfamid with anti-inflammatory, analgesic, antipyretic effects. The main active ingredient is nimesulide. He slows down chemical reaction prostaglandin E2 in the focus of inflammation and in ascending paths nociceptive system. A decrease in the concentration of prostaglandins in the body creates an analgesic and anti-inflammatory effect.
The drug is produced by the leader of the pharmacological market, the Berlin-Chemie company. Thanks to modern technologies, German manufacturers base their products on new generation components. The nimesulide group belongs to those, it has maximum effect with minimal side effects. Wide spectrum indications allows the use of Nimesil in various branches of medicine.
The preparation contains Excipients: ketomacrogol 1000, sucrose, maltodextrin, citric acid and orange flavor for flavor.
Indications for use
The drug is prescribed for children over 12 years old, available in several forms:
- Powder.
- Suspension.
- Lozenges.
- Dissolvable tablets.
The liver is mainly responsible for the absorption of the drug, the remains of the drug are excreted by the kidneys by 50%. In the blood, the maximum concentration is observed 2-3 hours after ingestion. The spectrum of action of the drug is extensive, indications for its use include:
- Pain in muscles and joints.
- Pain in lumbar and back.
- Inflammation of the tendons (tenderitis), periarticular tissues (bursitis).
- Sports injuries, sprains, bruises.
- Toothache.
- Pain syndrome in osteochondrosis and osteoarthritis.
- Pain during the menstrual cycle.
- Recovery after surgical intervention(removal of inflammation and pain).
- Colds, feverish conditions.
The drug is taken orally, the powder is first dissolved in warm water to a suspension state. Before use, it is important to read the contraindications.
Contraindications
Each body is unique, so before using the medicine, you should consult a doctor, he will help identify possible complications taking into account individual characteristics and compatibility with other drugs. It is not recommended to drink Nimesil in cases of:
- Pregnancy and the period of breastfeeding.
- Diseases of the gastrointestinal intestinal tract in the acute stage.
- Liver and kidney failure.
- Bronchial asthma in acute course.
- Hemophilia and other causes of poor blood clotting.
- Thrombophilia.
- Children under 12 years of age.
- Propensity to abuse alcohol.
- Individual intolerance to the components of the drug.
With caution it is necessary to use the drug for violations of the work of the heart - vascular system visual impairment, high blood pressure. In old age, the use of the drug is possible only under the supervision of a doctor. Babies under 12 years old can be given forms intended for children; when prescribing Nimesil to a child under 6 years old, strict supervision of a pediatrician is required.
If the use of Nimesil is shown to you, then it is important to correctly consider the dosage.
Application and dosage
A common version of the sale of the drug is a powder packaged in a sachet of 2 grams. This amount of the drug is a single dose, it should be diluted with 100 ml warm water. Standard use is 2 sachets per day for adults. For children, the dosage is calculated based on weight, 1.5 mg per 1 kg up to 3 times a day.
In cases where the patient is taking other medications, has liver problems or kidney failure, the doctor may reduce the dosage. At acute pain the dose may be increased. For children maximum dose is 5 mg per 1 kg 3 times a day.
According to the doctor's prescription, the drug can be used as a course of treatment, the daily dosage is minimal, the duration of the course is 15 days.
The tool can cause dizziness and drowsiness, so you should carefully monitor your condition, if it becomes necessary to drive, then it is better to abandon the idea. It is better to avoid driving a car until the drug has been eliminated from the body.
Proper dosage is essential for effective application and avoid side effects.
Adverse symptoms
Unpleasant symptoms appear only when there is a violation allowable rate, it includes:
- Nausea, heartburn and vomiting.
- Drowsiness, feeling of weariness and apathy.
- Raise blood pressure, dizziness.
- Allergic reaction: dermatitis, urticaria.
- IN rare cases exacerbation chronic diseases: ulcer bleeding, asthma attacks, exacerbation of renal failure.
- Possible in case of severe overdose anaphylactic shock and coma.
Nimesil for toothache
The drug belongs to broad action and can be prescribed for toothache. To relieve pain symptoms, dilute the powder according to the instructions. It is better to drink the suspension after a meal. The action can be felt 20 minutes after ingestion, the duration of the drug is 12 hours.
Due to the anti-inflammatory action, Nimesil can be used for gum disease, enter into therapy for fluxes or other soft tissue inflammations. Remember that the drug only alleviates the symptoms, but cannot cure diseases of the oral cavity, so a visit to the dentist is mandatory.
This medicine is effective way get rid of pain and inflammation. Thanks to broad list indications and the minimum number of contraindications, Nimesil is often used in medical practice. The cost of the drug is also its advantage. One sachet costs from 25 rubles, for a package of 30 pcs. will have to pay about 730 rubles.
In pharmacology, based on the basic active substance nimesulide created other drugs. Analogues include:
- Nimesulide tablets, their advantage is the price, average cost packs of 20 tablets - 40 rubles.
- Tablets Nise, price 170 rubles for 20 tab.
- Gel Nise for local application, cost from 150 rubles per 20 mg.
- Nimika tablets, price from 120 rubles for 20 pcs.
The advantage of Nimesil powder is its form, the suspension is absorbed faster into the intestinal wall, gives quick effect. By following all the recommendations of specialists, you can safely get rid of pain for little money.
Nimesil instruction - video
Nimesil is a medical drug that belongs to the group of anti-inflammatory non-hormonal drugs. active ingredient is nimesulide - a substance that removes pain, reduces the temperature, fights the inflammatory process.
In terms of its effect, Nimesil can be compared with drugs such as, for example, Ibuprofen, Diclofenac. All medical preparations of this group have a powerful systemic effect, but these tablets have much less effect on the state of the gastrointestinal tract. Nimesil is treated, both adults and children, for pain caused by trauma, rheumatic and infectious lesions, feverish conditions.
pharmachologic effect
Pharmacodynamics. Nimesulide is an anti-inflammatory nonsteroidal drug(NSAIDs) from the group of sulfonamides. Creates an antipyretic analgesic and anti-inflammatory effect. The tablets act as an inhibitor of cyclooxygenase extracts, which is responsible for the formation of prostaglandins and inhibits mainly cyclooxygenase-2.
Pharmacokinetics:
- After ingestion, the drug is well absorbed in the gastrointestinal tract, reaching the highest concentration in circulatory system In a few hours.
- Interaction with plasma proteins - 97.6%.
- The half-life is 3.3-5.5 hours.
Easily passes through histohematic protection. It is metabolized in the liver due to the cytochrome isoenzyme. The main metabolite is hydroxynimesulide, which is excreted in bile in a metabolized form (found only in the form of glucuronate).
Nimesulide is excreted from the body, as a rule, only by the kidneys (approximately 52% of the dosage used). Pharmacokinetic profile of tablets in elderly people does not change during the reception of any doses.
Indications for use
Nimesil tablets are indicated for the following diseases:
Dosage and method of use
Nimesil is indicated for oral administration, 1 tablet twice a day. The medicine is recommended to be taken after a meal. A drug mixed with water, approximately 100 ml. Nimesil is used only to treat people over the age of 12 years.
Features of use
The drug should be used with caution in people with gastrointestinal diseases (Crohn's disease, ulcerative colitis) as it is possible exacerbation of these diseases. The risk of bleeding in the stomach, ulcers increases with an increase in the dosage of NSAIDs in people with a history of an ulcer, especially complicated by perforation or bleeding, as well as in the elderly, therefore treatment should be started with the minimum effective dose.
In people taking drugs that inhibit platelet aggregation or reduce blood clotting, and also increase risk of bleeding in the stomach. If an ulcer or bleeding occurs, treatment with Nimesil should be discontinued. Since the tablets are partially excreted by the kidneys, doses for people with impaired kidney function should be reduced, taking into account the degree of urination.
There is evidence of a negative liver reaction to the drug. If symptoms of liver dysfunction appear (yellowing of the skin, pruritus, vomiting, nausea, dark urine, stomach pain) you need to stop taking the pills and consult a doctor.
Despite the rarity of visual disturbances in people who use Nimesulide along with other drugs, treatment should be stopped immediately. Tablets can retain fluids in tissues, so people with high blood pressure and with disorders of the heart, Nimesil must be used very carefully.
epidemiological data and clinical researches showed that NSAIDs, at higher doses and prolonged use, lead to insignificant the risk of having a stroke or a heart attack.
Nimesil contains sucrose, this must be taken into account for people who suffer from diabetes and patients on a low-calorie diet. A drug it is undesirable to appoint people with rare diseases such as sucrose-isomaltose deficiency, galactose-glucose malabsorption or fructose intolerance.
The drug can change the properties of platelets, because need to be careful patients with hemorrhagic diathesis, while the drug does not replace the preventive effect of acetylsalicylic acid in cardiovascular diseases.
Like all drugs of the NSAID group that inhibit the formation of prostaglandins, Nimesulide can adversely affect the course of pregnancy and lead to the following consequences:
- hypertension of the arteries of the lungs;
- closure of the arterial duct;
- increased risk of bleeding;
- disruption of the kidneys;
- the appearance of peripheral edema;
- decrease in uterine contractility.
Therefore Nimesulide prohibited during pregnancy and during breastfeeding. The use of Nimesil adversely affects the fertility of women and is not desirable for patients who are planning a pregnancy.
Side effects of Nimesil
Side effects from various systems:
interaction with other drugs
Nimesulide, when interacting with other drugs, can cause:
- Selective serotonin inhibitors and antiplatelet drugs such as fluoxetine: increase the risk of bleeding in the stomach.
- Glucocorticosteroids: increase the risk of bleeding and stomach ulcers.
- Diuretics: the drug may reduce the effects of diuretins.
- Anticoagulants: the drug may increase the effect of anticoagulants, such as warfarin. Due to the high risk of bleeding, joint reception of these drugs is undesirable and contraindicated in people with abnormal coagulation function. If the complex combination is still impossible to avoid, you need to control the level of blood clotting.
Contraindications to the use of the drug
Contraindications include the following conditions:
Caution must be taken if:
- severe forms of diabetes;
- arterial hypertension, ischemic disease, heart failure;
- creatinine clearance less than 60 ml/min, hyperlipidemia/dyslipidemia, cerebrovascular disease;
- smoking, peripheral arterial disease, infections caused by Helicobacter pylori, severe somatic diseases, anamnestic data on a gastrointestinal ulcer;
- prolonged previous use of NSAIDs, elderly age.
Concomitant treatment allowed by these drugs.: antiplatelet agents (eg, clopidogrel, acetylsalicylic acid), anticoagulants (eg, warfarin), reuptake inhibitors (eg, fluoxetine, citalopram, sertraline, paroxetine), oral glucocorticosteroids (eg, prednisolone).
The decision to use Nimesil must be based on the patient's personal risk-benefit assessment during the use of this remedy.
drug overdose
Signs: pain in the epigastric region, drowsiness, apathy, vomiting, nausea. During maintenance treatment of gastropathy, these signs are usually reversible. There may be bleeding in the stomach. Sometimes respiratory depression is likely, severe kidney failure, increase blood pressure, anaphylactoid reactions, coma.
Treatment: There is no specific antidote. In the case when an overdose occurred within 5 hours, it is necessary to induce artificial vomiting and take an osmotic laxative or activated charcoal (70-120 grams for an adult). Hemodialysis, forced diuresis - ineffective due to increased communication Nimesil with proteins (up to 97.6%). Requires monitoring of the liver and kidneys.
Treatment with Nimesil needs control and a serious attitude on the part of the doctor if it is used simultaneously with diuretics and anti-inflammatory drugs, as well as with medical drugs that correct the pressure.
Nimesil can have an effective anti-inflammatory and analgesic effect. However, it is necessary to use it not on the advice of friends and relatives, but only after doctor's recommendation. Just so you won't let negative consequences, you need to carefully control the dosage of this drug.
A person over 15 years of age, on average, has some kind of pain once every one to two months. May have a headache, teeth; periodically (at already mature age) joints ache. And you can’t get away from a cold at all, in which the temperature rises. In pain syndrome and inflammatory conditions, the drug Nimesil is often prescribed, the instructions for which contain a rather extensive list of side effects. How to take nimesil powder to minimize the risks for yourself.
What is Nimesil
Nimesil is a remedy for reducing inflammation, relieving pain and reducing to normal numbers. elevated temperature body. It is called "non-steroidal", which means that it is not hormonal (corticosteroid hormones produced in the human adrenal glands have similar properties to eliminate the symptoms of inflammation). Nimesil is produced in the form of tablets, a gel for skin application, an injection solution, lozenges, and a powder with granules for the preparation of a drinking suspension.
The essence of the action of Nimesil is that it blocks one of the enzymes, which starts the development inflammatory response accompanied by pain, swelling, fever. At the same time, the drug has practically no effect on another fraction of the same enzyme, which is responsible for the production of protection from the stomach. of hydrochloric acid. That is, the drug Nimesil (Nimide, Nimesulide, Nimegesic), taken correctly, has a small chance of damaging the mucous membrane of the initial sections of the gastrointestinal tract, unlike its non-selective "brothers" Diclofenac, Aspirin, Analgin, Ibuprofen. But there is still a risk, so you still need to know how to dilute nimesil powder.
The concentration peak of the drug in the blood is observed after 2-3 hours. It is metabolized in the liver, excreted in both feces and urine. The maximum half-life is 6 hours.
When you need Nimesil
The drug is prescribed for:
- acute toothache;
- postoperative pain syndrome;
- pain in rheumatoid and osteoarthritis;
- pain syndrome during menstruation, as well as gynecological diseases;
- to reduce temperature in inflammatory diseases.
Mode of application
How to drink Nimesil powder. For children over 12 years of age, the drug is prescribed at a dosage of 100 mg (1 sachet) twice a day with an interval of at least 8 hours. Optimal daily dosage- 200 mg (1 sachet twice a day with an interval between doses of 12 hours). In the early days viral infection or after surgery, 300 mg of the drug is allowed. It should be noted that this remedy is prescribed by a doctor, since it is not the basis of treatment, if there is no effect within 3 days, it is necessary to seek medical help.
How to breed Nimesil. The contents of the sachet are poured into a glass and pour 100-150 ml of cool boiled water. The finished suspension has an orange flavor; dissolve the powder immediately before use, since the suspension is not stored in a diluted form.
To reduce the risk of exacerbation of gastritis or the appearance of symptoms stomach bleeding, take Nimesil after meals.
Contraindications
Nimesil should not be taken with:
- allergies to this drug or a drug from this group;
- exacerbation peptic ulcer;
- conditions that are accompanied by increased bleeding;
- severe degrees of renal, hepatic and heart failure;
- children under 12;
- all trimesters of pregnancy and lactation.
Side effects
You can list the following side effects Nimesil (by frequency of occurrence):
- diarrhea;
- nausea and/or vomiting;
- an increase in the blood levels of ALT and sometimes bilirubin;
- constipation;
- exacerbation of gastritis;
- flatulence;
- increased blood pressure;
- skin itching;
- increased sweating;
- hives;
- swelling;
- dyspnea;
- fainting state;
- violations of blood counts;
- anaphylactic shock;
- panic attacks;
- terrible dreams;
- nervousness;
- Reye's syndrome;
- sensation of "tides";
- fluctuations in blood pressure;
- increased heart rate;
- stomach bleeding;
- visual impairment;
- blood in the urine;
- decrease in the volume of urination;
- decrease in temperature to subnormal figures (below 36.0 ° C).
The instruction indicates that the chance of developing side effects decreases if the drug is taken as much as possible. short course. Since Nimesil has a toxic effect on the liver, it should not be taken simultaneously with alcohol and drugs that reduce blood clotting (Warfarin, Aspirin). It is also prohibited to use at the same time this drug with other analgesics.
Nimesil is a drug from NSAID groups.
Nimesil composition and release form
The drug Nimesil is produced in granules of a light yellow color, which are intended for the preparation of a suspension, it must be used by the enteral method (inside), ready dosage form has an orange scent. The active compound is nimesulide at a dosage of 100 milligrams.
Excipients Nimesil are as follows: ketomacrogol 1000, orange flavor, sucrose, maltodextrin, anhydrous lemon acid. The drug is packaged in laminated sachets of two grams. Sold by prescription. The shelf life is two years, it is contraindicated to use the medication after this time.
What is the action of Nimesil?
The drug Nimesil refers to sulfonamides. It has an anti-inflammatory effect on the body, has analgesic and antipyretic effects. The active compound nimesulide inhibits the enzyme cyclooxygenase, prevents the biosynthesis of prostaglandins.
After taking the medicine inside, Nimesil is well absorbed. The maximum concentration of the drug is reached after two to three hours. Protein binding is high, approaching 98%. The elimination half-life varies from 3 to 6 hours. Nimesulide is metabolized in the liver. The main metabolite is hydroxynimesulide. Excreted through the intestines and kidneys.
Who is Nimesil intended for, what helps?
The drug Nimesil is indicated for use in the following situations:
Assign a remedy for acute pain in the back, lower back;
The drug is effective for injuries, dislocations, sprains, bursitis, as well as toothache;
With algomenorrhea (painful menstruation).
In addition, the drug is used for pain syndrome, which develops against the background of osteoarthritis.
What are Nimesil's contraindications for use?
The anti-inflammatory drug Nimesil is contraindicated in the following situations:
If there is a history of bronchospasm, rhinitis, urticaria associated with the use of acetylsalicylic acid;
History of hepatotoxic reactions to nimesulide;
After the so-called coronary artery bypass grafting;
At the same time, this remedy is not prescribed with paracetamol, as well as with other drugs from the NSAID group, in order to avoid severe hepatotoxicity;
Inflammatory pathology intestines during an exacerbation, for example, Crohn's disease,;
The presence of fever in inflammatory and infectious pathology;
Breast-feeding;
Drug addict;
When a violation of blood coagulation is detected;
Exacerbation of peptic ulcer;
Up to 12 years;
The presence of bleeding, including cerebrovascular;
Pregnancy;
;
kidney failure;
Alcoholism;
Liver failure;
Hypersensitivity to drug substances.
With caution, Nimesil is prescribed in such situations: severe hypertension, type 2 diabetes, smoking, heart failure, coronary artery disease, in addition, dyslipidemia, old age, hyperlipidemia, the presence of Helicobacter pylori, severe somatic pathology, concomitant treatment anticoagulants, antiplatelet agents, oral glucocorticosteroids.
How to take Nimesil (powder)?
The drug Nimesil is usually taken orally one sachet after meals twice a day. First, the contents of the laminated bag are carefully poured into a glass, then 100 milliliters of water are added and the drug is dissolved.
The prepared suspension should be used as soon as the granules are completely dissolved, it should not be stored. The maximum duration of therapeutic measures with Nimesil can last no more than fifteen days.
Nimesil - drug overdose
Symptoms of an overdose of Nimesil: apathy, drowsiness, nausea, vomiting are characteristic, pain in the epigastrium is observed, an increase in pressure is possible, as well as coma. The patient is provided symptomatic therapy.
What are Nimesil side effects?
The drug Nimesil causes the following adverse reactions: anemia, eosinophilia, itching rash, hemorrhagic syndrome, there may be hypersensitivity reactions, as well as thrombocytopenia, headache, pancytopenia, erythema, dermatitis, urticaria, thrombocytopenic purpura are not excluded, characteristic blurry vision, available angioedema, dizziness, epidermal necrolysis, drowsiness, a feeling of fear, hypertension, nervousness, and nightmares join.
In addition, taking the drug can lead to encephalopathy, tachycardia, hot flashes, shortness of breath, dysuria, exacerbation of asthma, diarrhea, bronchospasm, nausea, vomiting, hematuria, constipation, flatulence, urinary retention, gastritis, in addition, hepatitis, abdominal pain , tarry stools, cholestasis, stomatitis, elevated liver enzymes, oliguria, renal failure, hypothermia, and interstitial nephritis, malaise, hyperkalemia, hypothermia, asthenia.
special instructions
Undesirable side effects of the drug Nimesil can be leveled with a minimum effective dosage medications, as well as short-term treatment.
What are Nimesil's analogues, how to replace?
Conclusion
Be healthy!
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Compound medicinal product Nimesil
gran. d/n susp. 100 mg sachet 2 g, No. 9, No. 15gran. d/n susp. 100 mg sachet 2 g, № 30 UAH 55
Nimesulide 100 mg
Other Ingredients: Ketomacrogol 1000, sucrose, maltodextrin, orange flavor, anhydrous citric acid.
Dosage form
Pharmacological properties
nimesulide (4-nitro-2-phenoxymethanosulfonanilide) - NSAIDs of the methanesulfonanilide group, has anti-inflammatory, analgesic and antipyretic effects. Therapeutic effect nimesulide is due to the fact that it affects the metabolism arachidonic acid and reduces the biosynthesis of prostaglandins by inhibiting COX. Due to the selective action on COX-2, it does not violate the synthesis of prostaglandins with a cytoprotective effect in the gastric mucosa, which reduces the risk of side effects. In addition, nimesulide reduces the formation of superoxide anions by neutrophilic granulocytes and inhibits the formation free radicals formed during inflammation.Well absorbed at oral intake, reaching maximum concentration in blood plasma after 1-2 hours. The half-life is 2-3 hours, and the duration of action is about 6-8 hours. About 98% of the drug is excreted from the body within 24 hours. long-term use does not accumulate in the body.
Indications for use Nimesil
rheumatoid arthritis, osteoarthritis, bursitis, tendonitis, pain syndrome different etiologies: in gynecological diseases and pathology of ENT organs, in postoperative period, with injuries, after dental interventions.Contraindications
hypersensitivity to the components of the drug, acetylsalicylic acid or other NSAIDs gastrointestinal bleeding, peptic ulcer stomach or duodenum, severe renal dysfunction, pregnancy and lactation, childhood up to 12 years old.Usage Precautions
should be used with caution in patients with a tendency to bleeding, diseases upper divisions Gastrointestinal, patients who take anticoagulants or antiplatelet agents. If, when using nimesulide, patients experience changes in liver function or symptoms of liver damage (anorexia, nausea, vomiting, abdominal pain, dark urine), then nimesulide therapy should be discontinued.The dose in patients with impaired renal function should be reduced. Given the reports of visual impairment in patients who have taken other NSAIDs, treatment should be stopped immediately if any visual impairment occurs, the patient may undergo an ophthalmological examination.
The drug can cause fluid retention in the body, so in patients with hypertension and heart failure, it should be used with extreme caution.
The drug may cause drowsiness or dizziness.
The drug should be administered with caution to elderly patients.
Nimesil contains sucrose, which should be considered when prescribing to patients with diabetes as well as those who follow low calorie diet. The drug should be used with caution in patients with impaired liver function. If changes in the level of activity of liver enzymes are detected, the drug is canceled and is not prescribed in the future.
