home Auditorium 7 Tsiprolet when to take. Use during pregnancy and breastfeeding. Drugs with similar effects

Tsiprolet when to take. Use during pregnancy and breastfeeding. Drugs with similar effects

As you know, most diseases are caused by bacteria. Nowadays, it is impossible to do without the use of antibacterial agents - antibiotics and antimicrobials. “Tsiprolet” is very popular among doctors, which is prescribed to combat various infections. However, patients often have a question about whether Tsiprolet is an antibiotic or not. The confusion stems from the fact that various sources define it differently. So let's figure it out.

Is Tsiprolet an antibiotic or not?

In fact, there is no clear answer to this question. There is still controversy over which group of medications fluoroquinolones should be classified as. Their action is aimed at disrupting the DNA synthesis of the microorganism and its further death. Moreover, these substances are active against microorganisms that are both at rest and in the reproduction stage. Their spectrum of action is aimed at destroying gram-positive and gram-negative bacteria, which makes it possible to use them for various infectious diseases. This is the main similarity between fluoroquinolones and antibiotics.

However, both substances are different from each other chemical structure and origin. Unlike antibiotics, which are a product of natural origin or a synthetic analogue thereof, fluoroquinolones have no analogues in nature. Therefore, the question of whether “Tsiprolet” is an antibiotic or not is very controversial.

Features of the drug's action

"Tsiprolet", as mentioned above, is an antibacterial agent of artificial origin. The active ingredient is ciprofloxacin from the group of fluoroquinolones, which have the following properties:

have a detrimental effect on most microbes;
easily penetrate into the cells and tissues of the body;
at long-term use does not cause addictive pathogens;
do not cause qualitative or quantitative damage to vaginal and intestinal microflora.

All these qualities are characteristic of Tsiprolet. When the drug enters a bacterial cell, it prevents the formation of enzymes that take part in the reproduction of infectious pathogens, after which the microbial cells die. Nowadays, the drug is prescribed for the treatment of many diseases, as it has wide range action and only some bacteria show resistance to it. Basically, "Tsiprolet" is used on initial stage disease or in cases where other medications have proven ineffective.

Today there are 4 generations of fluoroquinolones. "Tsiprolet" (antibiotic) belongs to the 2nd generation. It effectively fights harmful bacteria such as E. coli, staphylococci and streptococci. The drug is well and quickly absorbed in the intestines, after which it enters the blood, along with which it enters tissues, organs and bones. It leaves the body mainly with urine, and the rest with feces and bile.

Thanks to affordable price and high efficiency, many patients prescribe antibiotics on their own. But here it is important to understand that the pathogen may not always be sensitive to it. In addition, "Tsiprolet" has its own contraindications, so it should be taken with caution for certain diseases.

In what cases is it prescribed

"Tsiprolet" (antibiotic) is intended for the treatment of various infectious diseases caused by bacteria sensitive to the active substance (ciprofloxacin).

The drug is prescribed for acute infections respiratory organs, namely with chronic bronchitis, abscess, pneumonia, empyema and infectious pleurisy.
It is also used to treat inflammatory diseases kidneys and bladder. Small doses of the drug can get rid of cystitis and eliminate the inflammatory process in the kidneys.
Quite often it is used to combat infections that cause gynecological and urological ailments, including infections that are transmitted through sexual contact.
"Tsiprolet" (we reviewed the composition of the drug) allows effective therapy in the field of surgery. Thus, it is widely used in the treatment of abscesses, carbuncles, boils, mastitis and other infectious diseases of the skin and soft tissues.
An antibiotic is also indicated to eliminate infections of the ENT organs.
It is also used for inflammatory processes in abdominal cavity(peritonitis, abscess).
For infections of bones and joints (acute and chronic osteomyelitis, purulent arthritis).
For infectious eye diseases such as keratitis, conjunctivitis, blepharitis and others. In this case, Tsiprolet drops are used.
For the purpose of prevention purulent infections the drug is prescribed after surgery.

Contraindications

"Tsiprolet" (antibiotic), like any drug, has contraindications.

Its use is prohibited for women during pregnancy and breastfeeding. Also, Tsiprolet should not be taken by children under 18 years of age. The ban is explained by the fact that during this period their skeleton is actively formed. IN extreme cases Tsiprolet may be prescribed to children over 15 years of age, but in this case constant medical supervision is necessary.

Patients with circulatory disorders, cerebral atherosclerosis, epilepsy and mental disorders, the medicine is taken only after the examination.

It is not advisable to take "Tsiprolet" for people with kidney and liver pathologies.

Side effects

Absolutely all antibiotics have side effects, and Tsiprolet is no exception. All possible Negative consequences are described in the instructions for the drug. The main ones are:

fainting and depressive state, migraine, dizziness, fatigue, insomnia, increased sweating, climb intracranial pressure, tremors of limbs, hallucinations;
gastrointestinal irritation, which is accompanied by loss of appetite, nausea, vomiting, diarrhea and abdominal pain;
allergic reactions;
development of anemia, leukocytosis, tachycardia, violation heart rate, a fall blood pressure;
in patients with severe diseases of the central nervous system, the drug can cause impaired coordination of movements and reduce psychomotor reactions.

Release form

The pharmaceutical industry presents "Tsiprolet" (antibiotic) in three forms:

Pills.
Solution for intramuscular and intravenous injections.
Drops.

"Tsiprolet" (tablets)

At inflammation of the lungs and moderate severity, the drug "Tsiprolet" is prescribed in tablets. The instructions for the tablet recommend taking it if acute bronchitis, cystitis, urethritis, prostatitis, and genital infections.

Also, taking the drug in this form is carried out for acute tracheitis, sinusitis and lesions of the larynx.

Treat with antibiotic tablets rheumatoid arthritis and arthrosis in the acute stage. In addition, the instructions for the tablet recommend using the drug "Tsiprolet" as medicine, used in the case of dysentery, salmonellosis and typhoid fever, as well as during exacerbation of chronic cholecystitis, duodenitis and cholangitis.

The drug is taken in tablet form for the treatment of complicated caries and periodontitis.

How and in what quantity is Tsiprolet taken?

The dosage is determined depending on the type of infection, the complexity of the disease, the age, weight and health of the patient.

Thus, for infectious diseases of the kidneys, urinary and respiratory tract moderate severity, take 250 mg of antibiotic twice a day. In more difficult cases the dose of the drug is 500 mg twice a day.

Gonorrhea is treated with a single dose of Tsiprolet at a dosage of 250-500 mg.

Gynecological diseases, enteritis and colitis with high fever and severe course, prostatitis, osteomyelitis require a double dose of 500 mg per day.

In order to achieve maximum effect, it is recommended to take antibiotic tablets before meals with a sufficient amount of water. The duration of treatment depends on the severity of the disease. It is important to note that the drug must be taken for at least 2 days after the symptoms disappear. As a rule, the treatment course lasts 7-10 days.

Tsiprolet injections

The injectable form of the drug is prescribed in more serious cases. "Tsiprolet" in injections is used for adnexitis, abdominal abscesses, sepsis, pyelonephritis and glomerulonephritis, severe upper respiratory tract infections.

Injections are used only in hospital settings. The required doses are selected by the attending physician taking into account weight, age, severity of the disease and concomitant diseases.

"Tsiprolet" (drops)

The instructions for the drug describe it as a drug that is prescribed for infectious and inflammatory processes affecting the organs of vision. These include: conjunctivitis, keratitis, blepharitis.

In addition, the instructions recommend using “Tsiprolet” (drops) as a prophylaxis after eye surgery, which helps prevent possible complications.

Antibiotics in the form of drops are also used to prevent secondary infection in case of eye injury or foreign body ingestion.

Treatment depends on severity inflammatory process. For infections moderate severity It is recommended to drip 2 drops every 4 hours. More severe cases require hourly instillation. The duration of therapy ranges from 4 to 14 days.

Tsiprolet and alcohol

Many people are interested in the question of whether it is possible to combine an antibiotic with alcohol. As is known, alcoholic drinks, especially in large doses, in themselves are dangerous poison, capable of causing serious damage to the liver. The instructions for the drug state that sometimes "Tsiprolet" as side effect may cause hepatitis. This is explained by the fact that the antibiotic has a hepatotoxic effect. Therefore, it is quite natural that “Tsiprolet” and alcohol are incompatible, since the liver will suffer doubly. And this, in turn, can result in quite serious illnesses organ. In addition, under the influence of alcohol, the drug works less effectively, as a result of which the microbes that Tsiprolet is obliged to destroy continue to live and recovery does not occur.

Another reason to give up simultaneous administration antibiotic and alcohol is that both substances, when combined, negatively affect coordination of movements, depress the central nervous system, provoking the possible onset of coma.

Analogues

What analogues does Tsiprolet have? There are many substitute drugs for antibiotics, which are produced by both domestic and foreign pharmacological companies. Like "Tsiprolet", the analogues also contain the active substance ciprofloxacin, which is a member of the group of fluoroquinolones. Today, the following drugs have a similar effect: Ciprofloxacin, Ciprobay, Tsiprinol, Quintor, Microflox, Alcipro, Oftocipro and others. Their difference lies in the price, which varies over a fairly wide range.

Let's sum it up

Based on numerous reviews about the drug, we can conclude that it is quite reliable and effective remedy, which can help even in the most severe cases. As shown medical practice, many microorganisms are sensitive to Tsiprolet. The drug works where other antibiotics fail. However, we must not forget that, like all antibiotics, Tsiprolet has some contraindications. Therefore, in order not to cause serious damage to health, it is better not to self-medicate, but to consult a doctor.

Tsiprolet tablets are prescribed for different bacterial diseases. This antibiotic is affordable and effective for bronchitis, pyelonephritis and other pathologies.

Tsiprolet - description and action

Tsiprolet belongs to the fluoroquinolone antibiotics. This drug is available in coated tablets. Contains ciprofloxacin in an amount of 250 or 500 mg. The cost of the medicine is low - 10 tablets of 0.25 g each costs 60 rubles.

The drug has a wide range of activities and is bactericidal.

After entering the body, Tsiprolet begins to inhibit DNA gyrase. This is a bacterial enzyme, without which further reproduction of microbial cellular proteins is impossible.

A feature of ciprofloxacin is the destruction of active infection, as well as bacteria located in latent phase(in "sleep mode") The most common gram-negative microbes are sensitive to the drug:

The medicine also destroys a number of intracellular pathogens - legionella, chlamydia. Tsiprolet also acts on gram-positive microbes - coccal flora; streptococci are only moderately sensitive to it. Clostridium deficille, bacteroides, and ureaplasma cannot be treated with Tsiprolet.

There is also a medicine on sale, Tsiprolet A, which additionally contains tinidazole, an antiprotozoal agent. Tinidazole is effective against Trichomonas and that infection that is insensitive to ciprofloxacin. This remedy is an order of magnitude more powerful.

Indications of the drug - when to use it?

The medicine is taken for diseases caused by exposure to active element microbes The main indications for use relate to infections respiratory system:

The tablets also help against infections of the kidneys and urinary system. They are especially often prescribed for acute cystitis, pyelonephritis. In women, with the help of this medicine can be treated gynecological diseases- adnexitis, salpingitis, endometritis, ovarian abscess. In men, Tsiprolet is used to treat acute prostatitis, and for rehabilitation of chronic prostatitis.

Tsiprolet's indications relate to infections of the oral cavity; it is prescribed after tooth extraction, excision of an abscess or cyst.

A course of treatment with Tsiprolet will help with infections biliary tract, other peritoneal organs. Tablets are recommended for soft tissue damage, infected wounds, ulcers, burns, bedsores, and inflammation of the skin of the legs in diabetics.

How to use the medicine?

The dosage is selected only by a doctor, since it depends on the severity of the infection and the type of disease. For children this drug they do not give it, it is used from the age of 18 years. Take the tablets on an empty stomach with 200 ml of water.

Gonorrhea is treated with a single dose of 500 mg. The duration of the course of therapy is determined by the doctor based on the positive dynamics. Most often, the course lasts a week - 10 days. It is important to continue treatment until symptoms are completely resolved, plus another 48 hours to prevent relapse.

The drug is excreted via the kidneys, so people with renal failure dose adjustment is required. Usually in such cases, 50% of the standard dose of Tsiprolet is prescribed. Patients on hemodialysis are prescribed 250 mg of the drug once a day.

Contraindications and negative effects of Tsiprolet

As with other fluoroquinolone antibiotics, Tsiprolet has an important limitation in its use. This is pseudomembranous colitis, which can worsen during therapy. Treatment is prohibited if you are allergic to drugs of this group, or if you are intolerant to ciprofloxacin.

The drug is contraindicated during pregnancy and lactation, under 18 years of age.

In some conditions, treatment with Tsiprolet can only be done under the supervision of a specialist. Treat with caution when cerebral atherosclerosis, chronically impaired cerebral circulation.

Seizures, epilepsy, psychical deviations also require controlled pill intake. In old age, with insufficiency of kidney and liver function, the dose is adjusted individually.

The most common side effects from the gastrointestinal tract are:

If a person has liver disease, there is a risk of developing jaundice, AST, ALT, and alkaline phosphatase increase. Headaches, anxiety, insomnia, hyperhidrosis, hearing loss, and fainting may also occur. Allergic reactions, arrhythmia, and pressure surges are possible.

Tsiprolet is antibacterial drug, which belongs to the group of fluoroquinolones.

It is highly effective against various harmful microorganisms, infectious and inflammatory pathologies. Available in the form of tablets, drops and solution for infusion.

There are many known diseases for which “Tsiprolet” tablets are used. What do they help with:

Inflammation of the ENT organs caused by infection;
Tracheitis, bronchitis, pneumonia;
Cystitis, glomerulonephritis, pyelonephritis, inflammation of the ureters;
Lesions of the genital tract, bacterial in nature;
Infectious lesions of bones and joints;
Diseases of the gastrointestinal tract;
Inflammation and suppuration of the skin.

Composition of the drug

Substance	Weight, mg
Main Components
Ciproxacin hydrochloride	291,106
Minor Components
Starch	50,323
Magnesium stearate	3,514
Colloidal silicon dioxide	5
Talc	5
Croscarmellose sodium	10
Microcrystalline cellulose	7,486
Shell
Hypromellose	4,8
Titanium dioxide	2
Talc	1,6
Macrogol 6000	1,36
Sorbic acid, polysorbate 80, dimethicone	0.08 mg each

Tsiprolet and Tsiprolet A: is there a difference

Tsiprolet is an antibiotic that belongs to monopreparations, since

What Ciprolet A tablets are for is described in this section

ciprofloxacin acts as the only active component of this drug.

Tsiprolet A is considered combined medication . It contains 2 active substances - ciprofloxacion 500 mg and tinizadol 600 mg.

This combination makes it more effective in treating various types of infections mixed type, when simple microorganisms attach to them. The list of recommendations and indications for use for Tsiprolet and Tsiprolet A is the same, only the second is used in the treatment of more severe and advanced stages bacterial lesions.

Tsiprolet tablets 250, 500 mg: instructions for use

The tablets must be taken orally full stomach with a small amount of water. When taken on an empty stomach, the active ingredient is absorbed more quickly.

The duration of treatment is determined by many indicators:

Antibacterial therapy does not stop after the removal of disturbing symptoms; it is recommended to take the tablets for another 2-3 days. The duration of treatment is determined by the attending physician.

How to drink Tsiprolet: dosage

Types of diseases	Single dosage (mg)	Reception per day	Course duration in days
Lower respiratory infections easy ways and medium degree	500	2	7-14
Severe degree of infection of the lower respiratory tract	750		7-14
Acute sinusitis	500		10
Lightweight and average degree infections skin and soft tissues	500		7-14
Severe lesions due to infection of the skin and soft tissues	750		7-14
Mild to moderate infection of bones and joints	500		28-42
Severe infection of bones and joints	750		28-42
Diseases of the urinary system of infectious nature	250-500		7-14
Uncomplicated form of cystitis	250-500		3
Chronic form of prostatitis	500		28
Uncomplicated gonorrhea	250-500	1	1
Uncomplicated diarrhea	500	2	5-7
Typhoid fever	500		5-7
To prevent the consequences of surgical intervention	250-500		7
In the treatment of sepsis and peritonitis	500	Every 12 hours	7-14
As a preventive measure anthrax in pulmonary form	500	2	60
Infections due to suppressed immunity (consequences that arise during treatment with medications that suppress the immune system or with neutropenia).	250-500	2	28

Indications for use

If the cause of infectious and inflammatory processes in the patient’s body is microorganisms that are sensitive to ciprofloxacin, then a course of therapy with the drug Ciprolet tablets is prescribed. What do they help with:

from infectious lesions of the respiratory tract. Bronchitis (acute, chronic form or during an exacerbation), pneumonia, bronchiectasis, complications of cystic fibrosis caused by infection,
from infections of the ENT organs. Acute sinusitis,
from infectious lesions of the urinary system ( bladder, kidneys). Cystitis and pyelonephritis,
from chronic prostatitis caused by bacteria,
from an uncomplicated form of gonorrhea,
from typhoid fever,
from diarrhea caused by infections, from campylobacteriosis, shigellosis, traveler's diarrhea,
from infections of the skin and soft tissues ( infected ulcers, wounds, burns, abscesses, phlegmon),
from infections of bones and joints (osteomelitis, septic arthritis),
from sepsis and peritonitis,
from infections that occur against the background of immune deficiency caused by therapy with immunosuppressive drugs or neutropenia,
as a prophylactic agent after surgical interventions,
as a prophylaxis against pulmonary anthrax.

Tsiprolet in dentistry

Tsiprolet is widely used in dentistry along with other antibacterial drugs. Tablets of this antibacterial agent help against various types of inflammation and infections.

Doctors note that they are also effective in preventing suppuration after surgery.

After tooth extraction

Antibacterial therapy is necessary after tooth extraction, however, at the discretion of the dentist, it can be canceled or not used at all if the extraction was uncomplicated. Tsiprolet tablets are prescribed to be used in a course of 5 days, 2 times a day, one tablet, which reduces the risk of inflammation, suppuration and infection.

For toothache

When the drug Tsiprolet enters the body, it begins to be actively absorbed into the blood. The tablets quickly eliminate pain, relieve inflammation and destroy pathogens. The medicine acts for 4-5 hours, after which it is excreted through the kidneys, which is why it has earned its popularity and widespread use.

With flux

Antibiotics are effective for flux in the first stages, when an abscess has not yet appeared; then Tsiprolet should be used only after the formation has been opened. The usual course of treatment is 5 days, 1 tablet every 12 hours.

Tsiprolet for bronchitis

In cases where the cause of bronchitis is bacterial infection, that is, grounds for prescribing antibacterial therapy. If pus appears in the sputum or with frequently recurrent bronchitis, antibiotics are also prescribed. The advantage here is given to drugs in tablets.

Tsiprolet helps well initial stages bronchitis or when other drugs have failed. The course of treatment and dosage are prescribed after examination and consultation with a doctor. Typically, taking Tsiprolet lasts no more than 10 days, one tablet 2 times a day.

For sore throat

At dangerous conditions purulent sore throat and allergies to others antibacterial agents Tsiprolet tablets are prescribed, which makes them indispensable in the treatment of this disease. Often, in acute form for sore throats, antibacterial drugs of the penicillin and macrolide series are powerless.

For severe angina, Tsiprolet is used in the form of an infusion solution.

For severe forms, 1-1.5 tablets are prescribed 2-3 times, also for 7-10 days. When the symptoms become less active, the drug is continued for another 3 days. For purulent sore throat, the drug is prescribed in an individual dosage for a course of 3-4 weeks to prevent complications.

Medicine Tsiprolet for sinusitis

Tsiprolet for sinusitis is used when bacterial infections are attached to it. The drug has side effects, for which it is used in cases where treatment with other drugs has proven ineffective.

Tsiprolet in gynecology for cystitis in women

Tsiprolet can be taken at any stage and for any degree of cystitis. The dosage is prescribed by the doctor based on the patient’s data – age, weight, as well as the severity of the disease and the presence of concomitant diseases.

The recommended dosage for the treatment of cystitis in women is 2 tablets per day with a break of 12 hours. The course lasts from 5 to 14 days. Experts advise women with kidney dysfunction to reduce the dosage of the drug by 2 times.

For prostatitis

In acute forms of prostatitis, the drug Tsiprolet is administered by the enteral route; after it enters the remission stage, tablets are prescribed. Switching to oral administration is possible on the 4th day of the injection course.

The recommended dosage of tablets for men with prostatitis is 500 mg every 12 hours. The appointment lasts 10 days and can be extended at the discretion of the doctor. It is also worth noting that in the presence of kidney or liver dysfunction, the dosage of Tsiprolet should be reduced by 2 times.

Tsiprolet for children: instructions for use

Children are not allowed to take antibiotics during active growth up to 18 years old.

If the clinical picture of the disease is complicated, then taking the drug Tsiprolet is allowed under strict medical supervision from the age of 15, and the dosage must be calculated and adjusted individually.

The recommended dose for eliminating complications caused by Pseudomonas aeruginosa in pulmonary mucoviscidosis in children aged 5-17 years is 20 mg per 1 kg of body weight every 12 hours (maximum daily dosage for a child should not exceed 1500 mg). The course lasts 10-14 days.

For the treatment and prevention of pulmonary anthrax, you need to take 15 mg per 1 kg of body weight every 12 hours. Maximum dose per dose for a child should not be more than 500 mg, and the daily dose should not be more than 1000 mg. The course lasts 60 days.

Contraindications

with a deficiency of glucose-6-phosphate dehydrogenase,
during pregnancy and breastfeeding,
pseudomembranous colitis,
under 18 years of age,
with sensitivity to the components of the drug and drugs of the fluoroquinol group.

You should take antibiotics with caution if:

significant atherosclerosis of the brain vessels of the head,
cerebral circulatory disorders,
mental disorders,
seizures, including epilepsy
kidney failure, liver failure,
after the age of 60 years.

Side effects

Side effects while taking the drug can be observed from:

	Digestion	Nervous system	Organs of perception	Of cardio-vascular system	Hematopoietic systems	Laboratory indicators	Urinary system	Allergic reactions	Musculoskeletal system
1	nausea	dizziness	hearing impairment	lowering blood pressure	anemia	hyperglycemia	urinary retention	itching	arthritis
2	diarrhea	headache	noise in ears	tachycardia	thrombocytopenia	hypoprothrombinemia	polyuria	hives	tendon ruptures
3	vomit	fast fatiguability	visual impairment	rush of blood to the skin of the face	leukopenia	hypercreatininemia	dysuria	bleeding blisters	myalgia
4	stomach ache	anxiety states	taste disturbance	heart rhythm disturbances	granulocytopenia	hyperbilirubenemia	albuminuria	drug fever	tenosynovitis
5	flatulence	insomnia	impaired sense of smell		leukocytosis		urethral bleeding	petechiae (point hemorrhages)	arthralgia
6	anorexia	tremor			thrombocytosis		hematuria	swelling of the face, larynx	arthritis
7	hepatitis	nightmares					decreased nitrogen excretion function of the kidneys	dyspnea
8	hepatonecrosis	disturbances in the perception of pain					crystalluria	increased photosensitivity
9	jaundice	sweating						eosinophilia
10		increased intracranial pressure						vasculitis
11		depression						erythema (nodular, exudative multiforme, malignant exudative (Stevens-Johnson syndrome)),
12		hallucinations						Lyell's syndrome.
13		migraine
14		fainting

In addition, it is possible that general weakness and superinfections - candidiasis and pseudomembranous colitis.

Is it possible to take Tsiprolet during pregnancy?

Antibiotic Tsiprolet belongs to the majority of drugs that are strictly prohibited during pregnancy and breastfeeding. Tsiprolet has not been tested on pregnant women, so its effect on the fetus has not been studied. Tests were carried out only on animals.

How many days to take the antibiotic Tsiprolet

The course of taking the drug is prescribed by the doctor depending on the disease or its severity, the age of the patient and concomitant diseases. The drug can be used either one-time or for a course of up to 60 days. In most cases, the duration of treatment ranges from 5-14 days.

How to take Tsiprolet: before or after meals

In order to increase the absorption of the drug by the body, and at the same time its effectiveness, it is recommended to take Tsiprolet tablets half an hour before meals with a glass of water. The drug can also be taken 2 hours after a meal with a glass of water.

Tsiprolet and alcohol - compatibility: is it possible to drink

When interacting with alcohol, the synthesis of liver enzymes that process ethanol and its breakdown products stops.

Then the symptoms of intoxication and their duration intensify, and severe poisoning occurs. Their degree is influenced by the amount of alcohol consumed and individual characteristics body.

Interaction with other drugs

when used with medications that affect the level of stomach acid ( antacids), products containing aluminum hydroxide, magnesium, calcium salts, iron and zinc can help reduce the absorption of ciprofloxacin by the body, so it is necessary to maintain a break of 1 to 4 hours between them,

when taking theophylline, you need to monitor its concentration, as it can rise significantly in the blood plasma,
when taken with cyclosporine, in some cases the concentration of serum creatinine increased,
when taken with warfarin, the effect of ciprofloxacin was enhanced in some isolated cases,
with high doses of quinols and other anti-inflammatory non-steroids, convulsions have been noted,
the drug can be combined during treatment with azlocillin, ceftazidime, mezlocillin, azlocillin, azoxazoylpenicillins, vancomycin, metronidazole, clindamycin.

Terms and conditions of storage

Tsiprolet tablets should be stored in a place that is protected from direct sun rays, where they are not accessible to children, and the temperature does not rise above 25 degrees.

The shelf life of the drug is 3 years, after which it cannot be taken.

Do I need a prescription to buy Tsiprolet?

The antibiotic Tsiprolet can be bought at any pharmacy without a doctor's prescription. You just need to ask the pharmacist for the drug.

How much does Tsiprolet tablets 250, 500 mg cost – price

Ciprolet in tablet form is inexpensive. For a package of the drug 250 mg you can pay 50-60 rubles, for 500 mg 100-120 rubles.

How to replace Tsiprolet - cheaper analogues

Ciproloxacin – price from 23 rubles,
Vero-Ciprofloxacin – from 50 rubles,
Quintor - from 90 rubles.
Ciloxan – 60 rubles,
Ecotsifol (ciprofloxacin) – 80 rubles.

Tsifran or Tsiprolet: which is better

Tsifran is an analogue of Tsiprolet. It is also active against gram-positive and gram-negative microorganisms; fungi, viruses, syphilis pathogens and some anaerobic organisms are resistant to it.

Both drugs have similar indications and contraindications for use. Unlike Tsifran, Tsiprolet interacts more effectively with other drugs.

Tsipromed or Tsiprolet: which is better

Tsipromed is another analogue of Tsiprolet, it contains the same active substance. These 2 drugs differ in price - if Tsiprolet drops cost 50-60 rubles in a pharmacy, then Tsipromed is about 100-140 rubles. Tsipromed is available in the form of ear and eye drops.

The drug Tsiprolet in tablets is effective in treating various diseases and bacterial lesions, for which it is actively used in medicine. Low price and high availability, when choosing an antibiotic, allow you to make a choice in its favor.

Application ciprofloxacin fatal to aerobic gram-negative microorganisms – enterobacteria (Salmonella, Escherichia coli, Shigella, Klebsiella, Proteus, Enterebacter, Serratium, Edwardsiella, Hafnium, Morganella, Yersinia, Vibrio). Others gram-negative bacteria (Pseudomonas, Haemophilus influenzae, Moraxella, Pasteurella, Aeromonas, Campylobacter, Neisseria). Some intracellular (Legionella, Listeria, Brucella, Mcobacteria) and representatives of aerobic gram-positive bacteria (Streptococcus and Staphylococcus).

In the case where it is observed resistance staphylococci To methicillin , they are most often resistant to ciprofloxacin , however this resistance forms extremely slowly due to the fact that microorganisms don't produce , inactivating the drug and due to their extremely small amount remaining after its exposure.

When taken orally, both active ingredients are well absorbed from the gastrointestinal tract, while their intake with food, although somewhat slows down the absorption process, does not affect bioavailability and Cmax.

Bioavailability tinidazole is at the 100% level. Connection with plasma proteins – 12%. Cmax after internal administration of 500 mg is observed after 120 minutes and is equal to 47.7 mcg/ml.

IN cerebrospinal fluid is found in the same concentrations as in . IN renal tubules undergoes a reabsorption process. T1/2 varies at 12-14 hours. Metabolic transformations are carried out with the assistance of cytochrome P450 in the liver. It is excreted 25% with urine, 50% with bile, and 12% in the form.

Renal pathologies when CC is more than 22 ml/min, they do not affect pharmacokinetic parameters tinidazole .

Bioavailability ciprofloxacin ranges from 50-85%, and the connection with plasma proteins ranges from 20-40%. Vd is 2-3.5 l/kg, Cmax after internal administration of 500 mg is observed after 60-90 minutes and is equal to 0.2 mcg/ml.

Ciprofloxacin characterized by good penetration into tissues and liquid environments human body(except for fat-rich tissues, including nervous tissue). Tissue cumulation of the drug can exceed its plasma content by 2-12 times. Concentration values ciprofloxacin reach therapeutic levels in saliva, liver, tonsils, gallbladder, intestines, bile, skin, pelvic and abdominal organs, peritoneal fluid, uterus, prostate tissue, seminal fluid, endometrium, ovaries and fallopian tubes, urinary system and kidneys, lung tissues, skeleton, bronchial secretions, muscles, articular cartilage and synovial fluid. In the cerebrospinal fluid it is found in small concentrations, equal to 6-10% in the absence of an inflammatory process and 14-37% in its formation. It also has good penetrating ability ciprofloxacin in relation to ocular fluid, bronchial secretions, peritoneum, pleura, lymph and placenta. Content of the drug in , in comparison with plasma concentration, 2-7 times more. At pH levels less than 6.0 activity ciprofloxacin decreases slightly. 15-30% occurs in the liver with the release of low-active metabolites (formylciprofloxacin, sulfocyprofloxacin, diethylciprofloxacin, oxociprofloxacin). T1/2 takes approximately 240 minutes. The main elimination is by tubular filtration/secretion by the kidneys, in a ratio of 40-50% unchanged and 15% in the form of metabolites, and also to some extent by the intestines. A small amount of the drug can be excreted in the milk of a nursing mother. Renal clearance – 3-5 ml/min/kg, total clearance – 8-10 ml/min/kg.

Kidney pathologies increase T1/2 ciprofloxacin till 12 o'clock. With CC values greater than 20 ml/min, the amount of the drug excreted by the kidneys decreases, but without accumulation in the body, due to a compensatory increase in its metabolism and excretion by the intestines.

Indications for use Tsiprolet A

Indications for use of Tsiprolet A are mixed infections bacterial etiology which were caused by sensitivity to the effects of its active ingredients the simplest and/or microorganisms .

Respiratory system:

bronchiectasis ;
in an acute form (acute/chronic);
pneumonia .

ENT organs:

average ;
sinusitis ;
mastoiditis;
frontal sinusitis .

Oral cavity:

ulcerative gingivitis (acute);
periostitis.

Skeletal system:

septic arthritis ;

Genitourinary system:

pelvioperitonitis;
salpingitis;
oophoritis ;
tubular abscess.

Skin:

phlegmon ;
bedsores ;
abscesses ;
infected ulcers/wounds/burns;
skin ulcers arising from the syndrome diabetic foot .

Intra-abdominal infections:

intraperitoneal abscesses ;
infections of the biliary tract and gastrointestinal tract.

Other:

postoperative /post-traumatic infections .

Contraindications

The use of Tsiprolet A is prohibited for:

(including mentions of such in the anamnesis);
personal hypersensitivity (including previously observed reactions with imidazole and/or fluoroquinolone derivatives);
pregnancy;
depressed bone marrow hematopoiesis ;
breastfeeding;
organic diseases of the central nervous system;
acute porphyria;
concomitant use with (due to the risk of severe drowsiness or reductions );
under the age of 18 years.

Tsiprolet A is prescribed with extreme caution when:

Side effects

Sense organs:

smell/taste disturbances;
noise in ears ;
visual disturbances (changes in color perception , diplopia );
hearing loss .

Digestive system:

appetite disorders;
nausea ;
metallic taste;
dry mouth;
vomit ;
stomach ache;
/ ;
cholestatic jaundice (most often in patients with a history of liver pathologies);
hepatonecrosis .

Blood-forming organs:

Nervous system:

fast fatiguability;
coordination disorders (including locomotor ataxia );
anxiety;
peripheral neuropathy ;
convulsions;
fainting states ;
weakness;
peripheral paralgesia ;
cerebral arteries;
nightmares;
intracranial hypertension ;
other psychotic manifestations.

The cardiovascular system:

changes in blood pressure (most often in the direction of its decrease);

Urinary system:

dysuria ;
interstitial nephritis ;
hematuria ;
crystalluria (with decreased diuresis and alkaline pH of urine);
albuminuria ;
polyuria;
decrease in nitrogen-excreting renal function.

Allergic manifestations:

Laboratory indicators:

hyperbilirubinemia ;
hypoprothrombinemia ;
hyperglycemia;
increased levels of alkaline phosphatase and liver enzymes;
hypercreatininemia .

Others:

tendon ruptures ;
arthralgia;
superinfections ( pseudomembranous colitis , );
myalgia;
asthenia;
tenosynovitis ;
tides (usually to the skin of the face).

Instructions for use Tsiprolet A

The instructions for Tsiprolet A suggest oral (internal) administration. The tablets must be swallowed whole (do not chew/break), and washed down with 100-200 ml of water.

As a rule, 1 tablet is prescribed every 12 hours for 5-10 days. The tablets are taken 60 minutes before meals or 120 minutes after meals.

Overdose

In case of acute overdose, the dominant symptoms will be reversible lesions urinary system and, perhaps convulsions .

Treatment for such conditions is induction of vomiting followed by gastric lavage and further conducting supportive and symptomatic treatment. Efficiency is relative tinidazole – 100%, relatively ciprofloxacin - to 10%.

Interaction

Parallel use with indirect anticoagulants increases their effects, thereby increasing the risk of formation , which requires a revision of the doses of Tsiprolet A in the direction of reducing them by half.

Tinidazole enhances the impact ethanol-containing products , which leads to the development disulfiram-like reactions .

Co-administration with Ethionamide .

At increased activity harmful microorganisms, doctors recommend using effective medicine called Tsiprolet - instructions for use indicate medical indications, features and duration intensive care the specified medicine. In this generally accessible way, the bacterial infection will be eradicated in as soon as possible, and the severity of the disease does not matter. Tsiprolet for children is also suitable for use, but first you need to carefully read the instructions.

What does Tsiprolet help with?

This antibacterial drug belongs to pharmacological group fluoroquinolones, has several release forms, is effective against increased activity of pathogenic flora. In the affected organism it has bactericidal, anti-inflammatory, antimicrobial properties, and has a destructive effect directly on the integrity of membranes pathogenic microorganisms. Daily doses of the drug Tsiprolet depend on the disease and age of the patient.

Compound

Active ingredient The chemical composition of Tsiprolet is ciprofloxacin hydrochloride, which productively inhibits the synthesis of bacterial DNA, and has the same effect on harmful microorganisms at the active and passive stages of development. As a representative of the group of antibiotics, this medication acts systemically and is active against many microbes. Among these coli, staphylococci, streptococci, chlamydia, pathogens of typhoid, diphtheria, pneumonia, plague, tuberculosis, gonorrhea, etc.

Release form

Continuing to study antibacterial agents, it is immediately worth clarifying that Tsiprolet has several forms of release and is involved in several directions modern medicine. In modern pharmacology they are well known for their high efficiency:

tablet form for oral administration;
medicinal solution for intramuscular or intravenous administration;
eye drops for local use.

Pharmacodynamics and pharmacokinetics

The active component Tsiprolet quickly penetrates the systemic bloodstream, its high concentration in plasma reaches 1-2 hours after oral administration. If the drug is administered intravenously, the absorption of ciprofloxacin and the bioavailability rate are even higher. Treatment with Tsiprolet lasts for 6 hours, the metabolic process is observed in the liver, and is excreted by the kidneys as inactive metabolites, partially by bile and through the stomach. If the prescribed dosages are followed, the risk of intoxication is minimal.

Tsiprolet - indications for use

This antimicrobial drug prescribed for the treatment and prevention of infections, alone and as part of complex therapy. Such an order should only be carried out by a specialist, while unauthorized intervention can significantly harm one’s own health. Treatment with fluoroquinolones is effective, and the duration of therapy often varies between 5-10 days. This time is enough to stop the infectious process and ensure positive dynamics of the underlying disease. According to the instructions for use, the medical indications are as follows:

infectious diseases respiratory system: bronchitis, pneumonia, lung abscess;
gynecological infectious processes: inflammation of the ovaries and appendages, gonorrhea;
infections genitourinary system: pyelonephritis, cystitis, prostatitis;
toxic, infectious liver diseases: viral hepatitis, fatty degeneration, cirrhosis;
tendon diseases: acute and chronic arthritis;
staphylococcal infections;
infection of the dermis and soft tissues;
infectious diseases ENT organs: sinusitis, otitis, laryngitis.

In modern ophthalmology, eye fluid is prescribed for all forms of conjunctivitis, blepharitis, corneal ulcers, postoperative period and against the background of previous injuries with subsequent infection. The shape of the eye drops is the best in such clinical pictures, since it allows you to apply therapeutic measures directly to the site of pathology.

Contraindications

Intravenous or oral administration medication is possible only after careful study medical restrictions, potential side effects and health complications. According to the instructions for use, contraindications to the antibiotic Tsiprolet are as follows:

periods of pregnancy, lactation;
increased sensitivity body to active components;
tendency to allergies;
epilepsy, convulsive syndrome;
age restrictions depending on the form of release of the drug.

According to the instructions for use, Tsiprolet is contraindicated in patients with chronic heart or vascular problems, impaired cerebral circulation, obstruction vascular walls, tendency to bleeding. Doctors are afraid of seizures, so they recommend this prescription only in complicated clinical situations. For each dosage form There are some medical contraindications, but it is better to additionally consult with your doctor before starting the course.

Directions for use and dosage

Medicine Tsiprolet for correct use demonstrates a pronounced antimicrobial effect in the body. The method of administration, dosage and duration of intensive therapy depend entirely on the severity of the infection, the specifics and age of the patient. For each release form, it is recommended to provide separate tips for successful, fruitful treatment. So, if the doctor prescribed tablets for oral administration, the daily doses of Tsiprolet are as follows:

For kidney infection, urinary tract, respiratory system, it is indicated to take 250 mg twice a day in uncomplicated clinical pictures, 500 mg 2 times a day in complicated ones.
For successful treatment gonorrhea, a single dose is recommended medical product Tsiprolet in a dose of 250-500 mg. For other more dangerous diagnoses in the field of gynecology, this figure increases to 500 mg of the drug twice a day (break intervals - morning and evening).
Ampoules with medicinal solution indicated for intravenous drip administration. With a single dose of Tsiprolet 200 ml, the procedure time is 30 minutes, and for 400 ml – 1 hour (for complicated clinical pictures). Such healing sessions It is indicated to be carried out in the morning and evening for 1-2 weeks until stable positive dynamics of the characteristic ailment are ensured.

special instructions

Medicine When taken orally, you need to drink it whole, do not chew it, and wash it down with a sufficient amount of water.
It is better to carry out this procedure before meals, while avoiding overestimation of daily dosages. The desired effect will not occur faster, but an overdose of Tsiprolet is guaranteed.
The action of cyclosporine is productive, but can affect everything internal organs and systems, so there is a high probability of general intoxication.
In patients with renal failure, it is important to monitor creatinine clearance, otherwise treatment will serious complications to the affected organ.
If a patient with kidney problems is prescribed Tsiprolet, additional dialysis is possible to cleanse the blood of toxins and speed up therapeutic effect.
The drug does not reduce the activity of psychomotor functions, does not cause a feeling of drowsiness or an addictive effect.

Tsiprolet during pregnancy

According to the instructions for use, use the medication as directed during pregnancy and breastfeeding is strictly contraindicated. The active component penetrates the placental barrier and causes mutations in the fetus at any stage of pregnancy. In addition, it is actively released from breast milk, therefore, during the period of intensive therapy it is necessary to move the baby to artificial feeding, temporarily stop lactation.

In childhood

For young children, such antibacterial treatment is strictly contraindicated during intensive growth musculoskeletal system, i.e. up to 18 years old. In complicated clinical situations, Tsiprolet can be prescribed to a child aged 15 years, but treatment should proceed under strict medical supervision with individual adjustment of daily dosages of the medication.

Drug interactions

Doctors often prescribe Tsiprolet in combination with other medications to enhance the overall therapeutic effect, speed up the healing process significantly. According to the instructions for use, there is drug interactions. Here are the pharmacological interactions that are important for the patient and the attending physician to consider when prescribing an intensive therapy regimen:

In a duet with didanosine, the absorption of ciprofloxacin is reduced, which is facilitated by the aluminum and magnesium salts formed during the interaction.
The combined use of Tsiprolet and Theophylline increases the concentration of theophylline in the blood plasma.
In combination with antacids, there is a sharp decrease in the absorption of ciprofloxacin, so the interval between by oral administration at least 4 hours
Together, Tsiprolet and anticoagulants lengthen the time interval and the severity of bleeding.
The combination of Tsiprolet and Cyclosporine enhances the nephrotoxic effect of the latter medication.
The simultaneous use of Warfarin and the specified antimicrobial substance can potentiate the effect of the first drug.
The complex of Tsiprolet with NSAIDs can cause convulsions and requires immediate discontinuation of both medications.

Side effects

Tsiprolet tablets are more often prescribed for mild clinical symptoms, whereas intravenous injections appropriate for use in severe inflammation. In both cases, one cannot exclude the risk of developing side effects that require urgent discontinuation of the drug and selection of an analogue. Due to systemic action antimicrobial agent Tsiprolet side effects may be:

from the gastrointestinal tract: signs of dyspepsia, jaundice, hepatitis;
from the central nervous system: migraine, dizziness, tremor of the limbs, insomnia;
from the senses: blurred vision, dry mucous membranes; hearing loss;
from the outside of cardio-vascular system: flushing to the face, drop in blood pressure;
from the urinary system: alkaline urine reaction, low diuresis;
from the musculoskeletal system: ligament ruptures, tendon pain;
from the skin: local and allergic reactions, Lyell's syndrome.