Lincomycin injection instructions for use. Contraindications and side effects. General characteristics. Compound

Lincomycin, what does this broad-spectrum antibiotic help with? The drug is used to treat diseases caused by the activity of most gram-positive bacteria. When taking therapeutic doses of the drug, it acts bacteriostatically, and in more high concentrations has a pronounced bactericidal effect on the body. Lincomycin instructions for use prescribe its use for osteomyelitis, sore throat, otitis, and furunculosis.

Composition and release form

It is produced in the form of capsules and solution contained in ampoules. The package can contain 6, 10 and 20 capsules of 250 mg each. Ampoules can contain 1 ml or 2 ml of solution. They also produce Lincomycin-AKOS ointment, which is sold in tubes of 10 and 15 g. The antibiotic Lincomycin, which helps with infectious pathologies, contains the active substance of the same name and a number of auxiliary ingredients. The composition of Lincomycin-AKOS ointment includes lincomycin, which is in the form of hydrochloride.

Pharmacological properties

Lincomycin - antimicrobial drug, which belongs to the lincosamide group of antibiotics. It has a pronounced bacteriostatic effect, and with increasing dosage it has a bactericidal effect on the body. The mechanism of action of the drug Lincomycin, which helps fight pathogenic microbes, is to inhibit the process of protein synthesis in microbial cells.

Lincomycin hydrochloride is active primarily against aerobic gram-positive bacteria: Corynebacterium diphtheriae, Streptococcus spp. (except Enterococcus faecalis), Staphylococcus spp. (including strains producing penicillinase) and anaerobic bacteria(Bacteroides spp., Clostridium spp.). The instructions for Lincomycin indicate that this antibiotic Almost all gram-negative bacteria, protozoa, fungi, viruses and Enterococcus faecalis are resistant.

Medicine Lincomycin: what helps

Indications for the use of tablets and injections are as follows:

• bone and joint diseases infectious nature, the development of which was provoked by microorganisms sensitive to that drug (osteomyelitis, septic arthritis);
• infectious diseases of ENT organs and respiratory tract, provoked by sensitive microorganisms (used for sore throat, sinusitis, otitis media, bronchitis, pneumonia, tracheitis, etc.);
• illnesses skin And soft tissue which are provoked by microorganisms sensitive to the product (abscess, purulent wounds, mastitis, furunculosis, erysipelas, etc.).

Lincomycin-AKOS is used externally for inflammatory and purulent diseases soft tissues, skin, which were provoked by microorganisms sensitive to the active ingredient.

Lincomycin in dentistry is used to treat purulent and infectious processes that occur in oral cavity. In particular, the drug can be prescribed for the treatment of periodontitis, periodontitis, gingivitis, purulent abscesses and etc.

The drug Lincomycin: instructions for use

Capsules are used 3-4 times a day, 500 mg. Typically, the duration of treatment is from one to two weeks, with osteomyelitis - up to three weeks or more. Lincomycin capsules are taken several hours before meals, washed down big amount liquids.

Lincomycin is used intravenously according to the instructions up to 2 times a day, 600 mg. Lincomycin hydrochloride is administered intravenously by drip, 600 mg several times a day.

Children are prescribed Lincomycin capsules in a daily dose calculated as 30-60 mg per 1 kg of body weight. If necessary, Lincomycin hydrochloride is administered intravenously every 8-12 hours at the rate of 10-20 mg per 1 kg of body weight.

At local application in the form of an ointment, Lincomycin is applied in a thin layer to the affected areas of the skin several times a day. The ointment is used with caution for dermatomycosis and fungal skin diseases.

Contraindications

The instructions for use for the drug Lincomycin prohibit taking it if you are hypersensitive to it. active substance, as well as if the patient has severe dysfunction of the liver and kidneys. The use of Lincomycin is contraindicated in pregnant and lactating women due to the ability of the drug to penetrate the placental barrier.

Side effects

When using Lincomycin in ampoules and capsules, patients may experience the following side effects:

• gastrointestinal dysfunction (vomiting, painful sensations, nausea, stool disorders, increased activity of liver enzymes, esophagitis, hyperbilirubinemia);
• disorders of the hematopoietic process (thrombocytopenia, agranulocytosis, neutropenia, pancytopenia);
• allergic processes (skin itching, urticaria, rash, swelling, erythema multiforme, anaphylactic shock);
• muscle weakness, headaches, arterial hypertension, dizziness.

For any side effects You must immediately tell your doctor about this.

Drug interactions

The use of Lincomycin in combination with penicillins, cephalosporins, chloramphenicol or erythromycin can lead to antagonism antimicrobial action, and when treated together with aminoglycosides - to synergistic action. The medicine should be used with caution concomitantly with muscle relaxants peripheral action due to the possibility of increased neuromuscular blockade, which in some cases leads to apnea.

Antidiarrheal drugs reduce the bactericidal effect of the antibiotic. When using Lincomycin, it is necessary to take into account that this drug incompatible with barbiturates, kanamycin, ampicillin, novobiocin, heparin, calcium gluconate, theophylline and magnesium sulfate.

Analogs and price

Lincomycin can be replaced with the following drugs:

• Lincomycin hydrochloride;
• Lincocin Clindamycin;
• Dalatsin C;
• Clindamycin-Norton et al.

You can buy Lincomycin capsules in Moscow for 123 rubles, a solution for 50 rubles. The price of capsules in Minsk is 1.27-2.4, solution - 0.3-2 bel. ruble In Kyiv, the medicine costs 27-58 hryvnia. The price in Kazakhstan of LINCOMYCIN HYDROCHLORIDE solution 30% 2 ML No. 10 reaches 620 tenge.

Lincomycin hydrochloride belongs to the group of lincosamide bacteriostatic agents. This means that the drug acts mainly to interrupt the proliferation of pathogens. Pharmacological activity occurs only against gram-positive pathogens. All gram-negative pathogens, protozoa, viruses and fungi have high degree resistance to lincomycin.

At the same time, lincomycin instructions for use allow it to be used not only as a bacteriostatic agent. In large doses exceeding therapeutic doses, this drug can cause massive irreversible death of microorganisms. This property of lincomycin allows the development of flexible treatment regimens for various inflammatory diseases. So, on the first day, loading doses can be used to destroy adult microorganisms. In the future, maintenance treatment with therapeutic doses is possible to prevent re-contamination and the onset of bacterial proliferation in the human body.

The pharmaceutical industry produces various dosage forms lincomycin. This makes it convenient to use and does not create difficulties for use even at home. The most popular are lincomycin injections and tablets. also apply ointment And eye drops.

Lincomycin hydrochloride is absorbed in sufficient quantities from digestive tract. But there are a number of conditions for its correct use. In particular, lincomycin should be taken orally either 30 minutes before a meal, or 1-1.5 hours after that. Digestive processes reduce the efficiency of absorption from the stomach by 50%. At correct intake from gastrointestinal tract A total of up to 40% of the active substance is absorbed. The drug is detected in human blood 30 minutes after administration. Therapeutic concentration is maintained at high level, for several hours.

When administered intramuscularly, 100% of the active substance enters the blood plasma, and its half-life is more than 6 hours. This allows you to get by with 1-2 injections per day to maintain therapeutic concentration. Lincomycin hydrochloride easily penetrates all barriers and is found in cerebrospinal fluid, blood, brain, cerebrospinal fluid, bile, urine. This property allows the drug to be used for severe generalized infections, such as sepsis, peritonitis, inflammation of the membranes of the brain, damage to the heart, liver and kidneys.

After penetration into the human body, the antibiotic lincomycin binds to blood proteins and is transported to places where bacterial colonies accumulate. In areas of inflammation, it disrupts the synthesis of cell membrane protein and prevents the possibility of division and reproduction of bacteria. In large dosages, it destroys the bacterial cell membrane and makes it unviable.

The drug lincomycin: use in dentistry and treatment of diseases

Lincomycin is used in dentistry for the treatment and prevention of inflammatory diseases. This drug is highly active against microorganisms that cause dental caries. Therefore, in some cases, dentists prescribe rinsing with lincomycin solutions and applying ointment to the affected areas of the gums. After tooth extraction, lincomycin is used in dentistry to prevent secondary infection from attaching to the wound surface in the socket area.

During treatment therapeutic diseases Lincomycin is widely used for:

• lobar;
• acute pyelonephritis and cystitis;
• blood sepsis and peritonitis;
• acute;
• septic endocarditis;
• inflammation of the arachnoid membranes of the brain;
• extensive hematomas in the brain;
• cholecystitis;
• infectious colitis.

Most often, lincomycin is used in conditions specialized hospitals. This is due to a large number of contraindications and side effects provided by these antibiotics. Of particular danger are disorders of hematopoietic functions when lincomycin is consumed in large doses. This can manifest itself in the form of leukopenia and a reduction in the number of platelets, which leads to profuse bleeding and a decrease in the patient’s immunity level. After discontinuation of the drug, these peripheral blood picture indicators gradually return to normal.

Also worth noting side effects from the authorities digestive system. Here, liver dysfunction may occur, which manifests itself in the form of increased transaminases, the appearance of skin itching, the occurrence of chemical jaundice. IN severe cases hepatic coma may develop.

For external use, lincomycin ointment is used. The main indications for its use are erysipelas, suppuration of wound surfaces, and the addition of infection to burns.

Dosage of lincomycin depending on the method of use
Lincomycin tablets	1 tablet 4 times a day.
Intramuscular injections of lincomycin	2 ml 2 times a day.
Intravenous injections of lincomycin	2 ml (600 mg) + 10 ml of 0.9% sodium chloride solution once a day.
Lincomycin ointment	a thin layer or on a sterile napkin 2 times a day.

How to use lincomycin in ampoules

Lincomycin injections allow you to quickly and safely deliver the active substance through the bloodstream to the immediate source of inflammation in the human body. Lincomycin injections intramuscularly and intravenously are acceptable. IN severe conditions drip administration of the drug is used with short breaks in the first two days from the onset of the disease.

Lincomycin injections are prohibited for children under 1 month of age. After reaching one month old Intramuscular and intravenous drip administration of antibiotics is permissible. For adults, lincomycin is administered 1-2 times a day. The course of treatment is 5-7 days.

For intramuscular injection lincomycin in ampoules is completely ready for use. A 50 mm needle is used for insertion. The drug is injected deep into the gluteal muscle. The injections do not cause severe pain.

For intravenous administration lincomycin is dissolved in 10-15 ml of isotonic sodium chloride solution or 5% glucose solution. For drip administration of the drug, these solutions are taken in 250 ml per dose.

When will lincomycin tablets help?

Lincomycin tablets are used in dental practice to eliminate symptoms of inflammation. Lincomycin tablets can also be used for inflammatory diseases upper respiratory tract and paranasal sinuses nose In some cases, treatment of cystitis with lincomycin is effective. However, people with reduced immunity should not get carried away with this drug in tablets. In practice, there are cases when a woman, having cured bacterial cystitis with lincomycin tablets, received candidiasis of the external genitalia and fungal cystitis.

Lincomycin tablets are taken 4 times a day, 500 mg, depending on the prescription of the attending physician. It is advisable to use antifungal agents together.

What does lincomycin ointment treat?

Lincomycin ointment can be used on insect bites, cuts, wounds and abrasions that were contaminated at the time of injury. Before applying a layer of lincomycin ointment, the wound should be thoroughly washed and dried. It is allowed to use lincomycin ointment under a sterile dressing.

Contraindications to the use of lincomycin

The main contraindication for the use of lincomycin is individual sensitivity and intolerance to this drug. Therefore, skin tests must be performed before starting treatment.

Lincomycin hydrochloride should not be used if the patient has severe liver and kidney dysfunction. An undoubted contraindication is the lactation period.

The drug Lincomycin is one of the most popular in dentistry. Effective antibiotic actively fights purulent-infectious tissue lesions and has a detrimental effect on many types of pathogenic bacteria.

For what diseases of the oral cavity can you not do without Lincomycin? What forms of the drug are recommended for treatment inflammatory processes in dental practice? Let's figure it out.

Causes of bacterial infection

There are three tens in the mouth permanent species microorganisms. To these are added other bacteria that penetrate from external environment or internal organs.

Why yeast fungi, staphylococci, coli do not have a negative effect on the condition of the oral cavity? IN healthy body saliva prevents bacteria from multiplying excessively and prevents inflammatory processes.

When dental diseases occur, the balance is disrupted:

• with periodontitis, caries, stomatitis, the number of infectious agents increases so much that saliva does not have time to suppress their activity;
• the infection spreads quickly, disrupts normal condition fabrics;
• During inflammatory processes, purulent masses are formed containing millions of pathogenic microorganisms.

Antibiotics are used to fight pathogens. After antibacterial therapy the number of bacteria returns to normal, saliva is again able to control the volume and activity of microorganisms.

Composition and action

Lincomycin is an antibiotic with wide range actions. The drug belongs to the group of lincosamides. The active ingredient that ensures the high activity of the drug is lincomycin hydrochloride.

An antimicrobial drug in a therapeutic dose prevents the development of microorganisms, more high dosage has a noticeable bactericidal effect. Lincomycin disrupts protein synthesis in cells harmful microbes, causes their death.

Certain microorganisms are sensitive to the action of lincomycin:

• aerobic gram-positive bacteria - streptococci, corynebacteria, staphylococci;
• anaerobic bacteria – clostridia, bacteroides.

Antibiotic resistant:

• mushrooms;
• protozoa;
• viruses;
• enterococci;
• gram-negative bacteria.

Take note:

• never use antibiotics without a doctor's prescription. Not all pathogenic organisms are killed by the active substance in the drug you choose;
• taking an inappropriate antibacterial agent will negatively affect the intestines, stomach, and other organs and systems;
• bacteria will continue their destructive activity during the same period;
• An antibiotic sensitivity test will help determine the appropriate drug for treating a particular patient.

Release form

The manufacturer offers the drug in the following form:

• gel;
• Lincomycin capsules;
• injection;
• diplenes;
• ointment (used in the treatment of skin lesions).

For therapy dental diseases Capsules for oral use are recommended. If the case is severe, the doctor will prescribe injections of an antibacterial drug.

Contraindications

Restrictions when prescribing the drug:

• allergic reactions for clindamycin/lincomycin;
• breastfeeding period;
• pregnancy;
• age up to five years.

Side effects

The antibacterial agent causes negative manifestations in some patients:

• relaxation of skeletal muscles;
• weakness, dizziness;
• rashes on the body;
• disruptions in bowel function;
• fungal infections;
• decrease in the number of blood leukocytes;
• thrombocytopenia.

If you notice any side effects, consult your doctor. The specialist will assess the risks and adjust the dosage.

Benefits of the drug

Dentists often prescribe Lincomycin for purulent-inflammatory diseases. The drug, regardless of its form, exhibits high activity.

Positive points:

• lincomycin hydrochloride has a detrimental effect on many bacteria that are resistant to other antibiotics;
• active substance quickly accumulates in bone tissue. In addition to eliminating inflammatory processes in the gums and mucous membranes, the drug prevents the spread pathogenic microorganisms on the jaw bones;
• lincomycin remains active for a long time. It takes pathogenic microbes quite a long time to develop resistance to an antibacterial agent.

Name:

Lincomycin 250 mg

INN:

Lincomycin

Synonyms

Lincocin

ATX code: J01FF02

Pharmacotherapeutic group

Antimicrobial drugs for systemic use. Lincosamides.
Compound

Each capsule contains 250 mg of lincomycin.
pharmachologic effect
Pharmacodynamics

Lincomycin is effective against gram-positive microorganisms (staphylococci, streptococci, pneumococci, diphtheria bacillus) and some anaerobes, including pathogens gas gangrene and tetanus. Also active against mycoplasmas. Does not affect gram-negative bacteria, fungi and viruses. Active against microorganisms, especially staphylococci, resistant to other antibiotics. Resistance of microorganisms to lincomycin develops slowly.

IN therapeutic doses the drug acts bacteriostatically. The mechanism of action is associated with the suppression of protein synthesis by bacterial cells.
Pharmacokinetics

After oral administration, 20-30% is absorbed dose taken lincomycin. Maximum concentration in the blood is reached after 2-4 hours. Penetrates into different organs and tissues, including bone tissue and bile. It penetrates the blood-brain barrier poorly, but the permeability of the BBB increases with meningitis. Metabolized in the liver. Excreted in urine and feces.

Indications for use

The drug is used in the treatment of septic conditions caused by staphylococci and streptococci,

• for acute and chronic osteomyelitis,
• pneumonia,
• purulent infections skin and soft tissues,
• erysipelas,
• otitis and other infections caused by microorganisms sensitive to this antibiotic,
• especially for infections caused by microorganisms resistant to penicillins and other antibiotics, as well as allergies to penicillins.

Due to the fact that lincomycin accumulates in bone tissue, it is one of the most effective drugs in the treatment of acute and chronic osteomyelitis and other infectious lesions bones; joints.

Directions for use and dosage regimen

Lincomycin is taken orally 1 to 2 hours before or 2 to 3 hours after meals, since food intake slows down and reduces absorption. Single dose for adults - 0.5 g, daily dose - 1.0 - 1.5 g. Daily dose for children is 30-60 mg/kg body weight (in 2-3 doses at intervals of 8-12 hours). The duration of treatment, depending on the form and severity of the disease, is 7 - 14 days (for osteomyelitis - 3 weeks or more).
special instructions

The drug should not be combined with muscle relaxants. At long-term use systematic monitoring of liver and kidney function is necessary. If pseudomembranous colitis develops, discontinue treatment and administer vancomycin or bacitracin.

Side effects

• When taking lincomycin orally, nausea, vomiting, diarrhea, and abdominal pain are possible.
• In some cases, allergic reactions are possible,
• leukopenia, thrombocytopenia.
• With prolonged use, candidiasis may occur.

Contraindications

The use of Lincomycin hydrochloride is contraindicated during pregnancy (except when necessary for health reasons), if serious illnesses liver and kidneys, increased individual sensitivity to the drug, during lactation (it is necessary to suspend breast-feeding), in the early infancy(up to 1 month).
Precautionary measures

The drug is prescribed with caution for fungal diseases of the skin, oral mucosa, and vagina.
Interaction with other drugs

Enhances muscle relaxation caused by curare-like drugs. Antidiarrheal drugs, chloramphenicol, erythromycin weaken the effect. When combined with narcotic analgesics, the likelihood of developing respiratory diseases increases.
Release form

Capsules 250 mg in packaging No. 20 (in a jar or No. 10x2 in blister packs).

Manufacturer

RUE "Belmedpreparaty"

Lincomycin is a drug from a number of antibiotics used to treat sinusitis, diseases of the ENT organs, boils, stomatitis and other infectious processes. The drug destroys pathogens, eliminating inflammation and abscesses. Lincomycin is used for children only from a certain age and strictly as prescribed by a doctor.

Pharmacologically, Lincomycin belongs to antibacterial agents and is an antibiotic of the lincosamide group.

The action of Lincomycin is directed against anaerobic bacteria that provoke inflammation. Its active substance is able to penetrate the cells of pathogenic microbes and inhibit protein synthesis by binding to ribosomes.

Therapeutic doses of the drug exhibit a bacteriostatic effect, inhibiting the proliferation of bacteria. High doses have a bactericidal effect, killing harmful microorganisms.

Lincomycin is effective against many bacteria that are insensitive to penicillin and other antibiotics. In particular, the drug works against:

• Diphtheria bacillus;
• Clostridium;
• Mycoplasma, etc.

Lincomycin has virtually no effect on most gram-negative bacteria, as well as enterococci, neisseria, corynebacteria, viruses, fungi and protozoa.

Release form and composition

The drug is available in three forms: capsules (tablets), ointment and solution for injection. Main active ingredient: lincomycin hydrochloride.

Indications

Lincomycin is prescribed for the following pathologies:

• Lung abscess;
• Osteomyelitis;
• Erysipelas;
• , and other dental problems;
• Other infectious processes caused by microorganisms sensitive to the drug.

Instructions

The medication in any form is not used for newborns under 1 month. Tablets are approved for children from 3 years of age, and use in dental practice - from 5 years of age.

Contraindications

Lincomycin should not be used for treatment in the following cases:

• Young children - up to 1 month for solution, up to 3 years for ointments and tablets;
• Intolerance to any component of the drug;
• If available on clindamycin;
• For severe and

The medication should be given with caution in the presence of fungal infections of the skin and mucous membranes.

Side effects

When using the drug, the following undesirable effects may occur:

• Discomfort and dysbiosis, and vomiting;
• Pseudomembranous (the drug is discontinued);
• and glossitis (inflammation of the tongue);
• and skin allergic manifestations ();
• Reversible (decrease in the level of blood leukocytes);
• Weakness, drowsiness, etc.

Drug interactions

Lincomycin can be used together with aminoglycosides, as it enhances their effectiveness. The drug is not prescribed together with drugs that exhibit a bactericidal effect (chloramphenicol, etc.). There was a decrease in effectiveness medicine at simultaneous administration medicines against diarrhea.

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Overdose

The statistics do not record the consequences of an overdose of the drug. However long-term use medications in large doses can provoke candidiasis and pseudomembranous colitis. If such symptoms appear, you should stop taking the drug and immediately consult a doctor.

Price and analogues

Cost of the drug:

• Lincomycin in capsules 0.25 g (20 pcs.) – from 90 rubles;
• Lincomycin ampoules 30%, 1 ml (10 pcs.) – from 150 rubles;
• Lincomycin ointment 2% (15 g) – from 88 rubles.

The drug is available in pharmacies with a prescription. The medication should be stored away from children in a dark, dry place at a temperature of 15-25°C. The solution and tablets are valid for 4 years, and ointments for 2 years.

On sale you can find medicines that are similar in active substance and therapeutic effect. There are domestic and imported analogues drug:

• Clindamycin;
• Clindacil;
• Clindamycin-Norton;
• Ecolink;
• Dalatsin;
• Lincocel;
• Lincocin;
• Clindahexal;
• Pulxipron.

You can change the prescribed drug to an analogue only with the consent of the attending physician. Reviews show that the drug is indispensable for purulent processes dental nature. The disadvantage of the drug is strong negative impact on the gastrointestinal tract.