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Chronic prostatitis: treatment with antibiotics. Pros and cons of using Ofloxacin

Inflammation of the appendages often leads to various complications. Therefore, treatment of the disease should not only be timely, but also comprehensive.

Gynecologist during selection medicines must take into account the characteristics of symptoms and the condition of the woman’s body. Treatment is carried out various groups medications.

Doctors in most cases prescribe antibiotics and anti-inflammatory drugs to treat inflammation of the appendages and ovaries. In addition, there is symptomatic therapy with taking painkillers.

Differences in the treatment of acute and chronic forms

IN acute stage The use of painkillers and anti-inflammatory drugs is indicated. If the inflammation is bacterial in nature, antibiotics are used. When bright severe intoxication The patient is prescribed droppers with glucose, protein preparations, and rheopolyglucin. In the event of a purulent lesion, laparoscopy is performed to remove the pus.

Therapy chronic form complicated due to the erasure of symptoms. Therefore, the main treatment is prescribed during an exacerbation. During this period, antibiotics, anti-inflammatory drugs, sedatives and sedatives. During remission, the patient is recommended to undergo physiotherapeutic courses of acupuncture, electrophoresis, etc.

Treatment of inflammation of the appendages with antibiotics

Inflammation of the appendages of a bacterial nature is treated with antibiotics. When choosing them, the doctor should focus on the type and sensitivity of the microorganism that caused the disorder to various active substances. Antibiotics for inflammation of the appendages can be of different groups.

Amoxicillin has a strong bactericidal effect. An antibiotic is prescribed only by a doctor. This takes into account:

It can lead to side effects. Therefore, it must be taken with extreme caution.

Azithromycin has an active effect on the source of inflammation. It has increased bactericidal properties.

It is important to determine the type of adnexitis pathogen. An antibiotic is not prescribed if the disease is caused by the activity of gram-positive bacteria. They are resistant to drugs of this group.

The treatment regimen for inflammation of the appendages with tablets is prescribed by a doctor. On average, a woman takes two capsules per day. Take it one hour before meals or 2 hours after eating.

A mandatory drug in the treatment of salpingoophoritis is Metronidazole. The remedy can be prescribed in the form of:

  • solution;
  • tablets;
  • gel.

In most cases, oral administration is indicated. If powerful therapy is required, then in the hospital the patient is prescribed intravenous drip infusions. Local treatment carried out using suppositories and gel.

The product has effective influence against protozoa and anaerobes. He can cope with the disease even when strong antibiotics don't work.

The drug has antimicrobial, antiprotozoal and anti-inflammatory effects. It has been used for many years in the treatment of adnexitis.

Ofloxacin is an antibiotic with a broad spectrum of action. Most often it is used for adnexitis caused by the activity of gram-negative bacteria.

After administration, the tablet quickly disintegrates and is completely absorbed into the gastrointestinal tract. The active substances instantly reach the affected area, eliminating the influence of harmful microorganisms.

In most cases, the antibiotic is well tolerated by patients. But the instructions for the drug note that it can lead to side effects. Among them are:

  • rash on the surface of the skin and itching;
  • decreased appetite;
  • swelling of tissues;
  • depressed state;
  • nausea and vomiting.

When taking tablets, you must avoid contact with direct sun rays. Otherwise, photosensitivity develops.

Tetracyclines are widely used in the treatment of adnexitis. One of them is Doxycycline, which is active against various microorganisms.

The product is available in capsule form. The duration of therapy and dosage are selected by the gynecologist. Standard scheme involves taking two capsules twice a day. In this case, the interval between doses should be 12 hours.

In addition to tablets, the product is available in the form of a solution for intravenous administration. After just a few days of therapy, a significant improvement in the condition is noted.

Gentamicin is an antibiotic wide range actions. It penetrates into the inflammation site within a short period of time and eliminates Negative influence pathogenic microorganisms.

In addition to taking pills, anti-inflammatory drugs and physical therapy are prescribed. Treatment is carried out throughout the week.

Intravenous administration is carried out twice a day. Decomposition products are excreted in the urine. Therefore, it is contraindicated in patients suffering from kidney disease.

A fluoroquinolone antibiotic is Tsiprolet. It is prescribed for inflammatory processes various types in the appendages.

The drug is very effective. It affects gram-negative microflora. But some gram-positive bacteria, for example, staphylococcus, are also eliminated under its influence.

In addition, the product eliminates intracellular microorganisms. But it is not used when affected by anaerobic bacteria.

Amoxiclav has a combined effect - a remedy penicillin series. It contains clavulanic acid, which does not allow harmful microorganisms to get used to and become resistant to the drug component (amoxicillin).

Before the doctor prescribes Amoxiclav, he checks the sensitivity of the identified microflora to bacteria. After this, the drug is taken in accordance with a certain scheme.

If the disease manifests itself to a mild degree, then you need to take one tablet three times a day. The interval between doses is 8 hours. In case of exacerbation, the dosage may be increased. In this case, the dose per day should not exceed 6,000 mg.

Before administration, Amoxiclav is dissolved in water. You can also chew the tablet and take it with plenty of liquid. IN special occasions shown intravenous administration facilities.

Trichopolum contains metronidazole, the effect of which is due to antimicrobial and antiprotozoal properties. Treatment is carried out if the source of inflammation is anaerobic bacteria.

The drug is not prescribed to all patients. Admission is prohibited if:

Therapy is carried out for 10 days. In some cases, the course is extended. However, it is important to monitor liver function and blood counts during long-term use.

The third generation cephalosporin is Ceftriaxone. It is necessary for the treatment of various diseases infectious nature among women.

For adnexitis, the drug is prescribed if inflammatory process aggravated by bacterial infection.

Treatment can be carried out in conjunction with other antibiotics. The patient is indicated to administer the solution intravenously and intramuscularly.

Cifran contains ciprofloxacin. The drug belongs to the fluoroquinolones. Various microorganisms are sensitive to it, including both anaerobic and aerobic bacteria.

At the moment, the remedy is considered the most acceptable treatment option for adnexitis. In pharmacies you can purchase the drug in the form of:

  • tablets;
  • solutions;
  • drops;
  • ointments.

The fluoroquinolone Ciprofloxacin has a wide spectrum of action. It fights active bacteria that spread throughout the body.

Its action is also aimed at destroying microorganisms at rest.

The drug is prescribed for infection with Mycobacterium tuberculosis and chlamydia. But it is worth remembering that Ciprofloxacin will not affect methicillin-resistant flora.

Effective on initial stages disease is the drug Polygynax. Vaginal suppositories have anti-inflammatory and antibacterial effects.

Under the influence of body temperature, the suppository melts, and active ingredients slowly absorbed by mucosal cells. Due to this property, gynecologists often prescribe capsules rather than suppositories, which are inserted into the vagina once a day. Treatment is carried out for 14 days.

The product has some advantages over others. It does not penetrate circulatory system, therefore does not have a negative effect on the body. Also, the drug has virtually no contraindications.

The tetracycline antibiotic Unidox Solutab affects different kinds microorganisms.

In most cases, it is prescribed for the presence of intracellular bacteria (chlamydia).

The drug is completely absorbed from the gastrointestinal tract. Therefore, it acts much longer than Tetracycline.

It should be taken no more than 2 times a day. The course of treatment lasts about 7–10 days.

Painkillers

Inflammation of the appendages is often accompanied by severe pain. In this case, the gynecologist may prescribe painkillers. They can be in the form of suppositories and ointments.

Diclofenac helps eliminate the inflammatory process and relieve pain. It is quickly absorbed by mucosal cells. Due to penetration into the circulatory system, the product restores the body's condition, providing an antipyretic effect.

The drug has many contraindications. Among them are:

  • gastritis;
  • ulcer;
  • pregnancy;
  • allergies.

Indomethacin is a non-steroidal anti-inflammatory drug. It is often used in the treatment of adnexitis and other diseases genitourinary system women.

The drug is a suppository that is inserted into the rectum. Penetrating into the body, the active components:

The product has some contraindications. Among them are gastric ulcers, liver and renal failure, pregnancy.

The focal effect is Voltaren. The cyclooxygenase inhibitor has:

  • anti-inflammatory;
  • antipyretic;
  • analgesic effects.

When used, the likelihood of bleeding is prevented.

Other means

In addition to the main ones medications other drugs may be prescribed. They are not mandatory, but can significantly improve a woman's condition.

Remens has anti-inflammatory and anti-climacteric properties. It is prescribed for various diseases genitourinary system in women.

The drug is made on the basis natural ingredients. Homeopathic remedy includes:

  • secretion of cuttlefish glands;
  • snake poison;
  • pilocarpus extract;
  • sanguinaria extract;
  • black cohosh extract.

The product should not be taken during pregnancy and lactation. If you use it according to the instructions, the symptoms of adnexitis are quickly eliminated and the hormonal background. Remens also affects the nervous system, calming the body. After using the drug, many women note normalization and painlessness of the menstrual cycle.

Calcium gluconate has desensitizing properties. It can be prescribed in addition to the main therapeutic course.

Calcium chloride and gluconate help anti-inflammatory drugs act most effectively on the body. Therefore, gynecologists prescribe them for inflammation of the appendages, characterized by bloody discharge from the vagina.

The drugs are available in the form of solutions for injection. Up to 10 ml of solution (10%) is administered intravenously.

Therapy for adnexitis should be comprehensive. This is the only way to completely cure the disease.

Ofloxacin belongs to the broad-spectrum fluoroquinol antibiotics. The active ingredient of the drug can be absorbed almost instantly (provided oral administration), which makes treatment of ureaplasma with ofloxacin not only effective, but also fast. In addition, these drugs belong to those rare species tablets whose bioavailability is almost absolute, i.e. reaches 100%. Ofloxacin is used not only for the treatment of ureaplasmosis, but its permeability in the tissue of the genitourinary system is one of the highest in comparison with other tissues and organs.

When treating ureaplasma with levofloxacin, it is important to consider that food intake does not have a significant effect on the effect of the drug, but the dosage should be mentioned separately, since the dose prescribed by the doctor can be taken at a time, or can be divided into two doses. Depending on what regimen of ofloxin is chosen, you should buy tablets. This is due to the fact that when treating ureaplasma with ofloxin, tablets cannot only be crushed and chewed, but also divided. Therefore, it is important to select the dosage so that, regardless of the number of doses, it does not exceed the prescribed dose. daily dose.

As evidenced by cured patients who used ofloxacin for ureaplasma, reviews clearly confirm this - the effect of treatment will be much lower if treatment is stopped earlier due date. This is due to the fact that this drug, like any antibiotic, helps eliminate obvious manifestations the disease already 3-4 days after the start of treatment, but this does not mean that the disease has disappeared completely. To obtain lasting positive result Therapy for ureaplasmosis with levofloxacin should be completed within the prescribed period, which is usually 7-10 days. Reviews about the drug also contain information that side effects from the use of this antibiotic, although rare, can still occur. Thus, the following phenomena are most often mentioned in reviews:

However, there are not so many reviews from patients who received these side effects when treating ureaplasmosis with this drug that we can talk about their systematic nature. The drug is contraindicated for persons under 18 years of age, pregnant and lactating women, and patients with epilepsy.

27 Sep 2013, 16:04

Klacid with ureaplasma
Klacid must be classified as a group of semisynthetic antibiotics of the macrolide type. The drug has an antibacterial effect, thanks to which it can...

I had the opportunity to take Unidox Solutab twice.

First course - 10 days.

Then I thundered in gynecological department with another aggravation.

The diagnosis is salpingoophoritis.

They prescribed a huge bunch of medications - IVs with metronidazole, anti-inflammatory suppositories (I don’t remember exactly which ones) and the antibiotic Doxycycline.

Stomatitis, nausea and diarrhea- on these three points I was hit hard.

The second time it was much more serious. I am preparing for IVF and I was recommended to have my long-term obstruction removed before the procedure. fallopian tube. And I went for another laparoscopy. At the same time, I also had a hysteroscopy - basically 2 operations in one.

After the operation, I was prescribed anti-inflammatory treatment, which included my favorite Longidaza suppositories and Unidox antibiotics, but this time for 14 days.

The course of treatment this time was difficult for me.

The pills caused severe nausea and aversion to food. There was no stomatitis this time, but my gallbladder gave me unforgettable days - dyskinesia worsened so much that sparks flew from my eyes.

But that's not all.

At the end of treatment, summer unexpectedly began for us in July. Sun, heat and other delights.

And I just went to work. And my work sometimes has a traveling nature and I have to spend a lot of time outside the office in the open air) 😂 during the time that I was on sick leave, many objects had accumulated that required travel.

I am generally white-skinned and suffer from sun allergy. Therefore, without high spf creams I don’t go out in sunny weather. And a hat is a must.

So, after smearing myself with cream, putting on a cap and closed clothes, I went to work. Only the face and hands are visible. Generously coated with cream. But an hour passes and I realize that something is wrong... My hands and face begin to ache, as if I had scalded them with boiling water. My lips hurt, as if I had bruised them. And I remember that In the instructions for the antibiotic Unidox it is written that during treatment it is necessary to limit insolation. I understand that the so-called photosensitivity.

I wrap up work and go to the office. Along the way I become covered in large spots, my hands and face are burning, my heart is pounding. I'm having a drink allergy pill. The spots disappear within 2 hours. In the evening at home I apply it to my hands and face.

Unidox Solutab ® is a broad-spectrum tetracycline antibiotic, the main active substance which is doxycycline. The drug has a bacteriostatic effect (inhibits growth and development, which leads to a decrease in the population of pathogens) due to the suppression of the biosynthesis and influence on the metabolism of proteins located in the plasmalemma. Unidox Solutab ® is capable of disrupting the connection of certain types of ribonucleic acids with the ribosomal membrane. The antibiotic is highly active against infectious agents in the exponential phase.

Unidox ® is not advisable to use for infections caused by enterococci, acinetobacter, pseudomonas, proteus, serratia. Antibiotic activity extends to actinomycetes, rickettsia, ureaplasma, Haemophilus influenzae, Klebsiella, Treponema, Neisseria, Enterobacteriaceae, etc. Antibacterial drug prescribed only after reaching eight years of age.

Medicines are used in their practice by venereologists, gastroenterologists, dermatologists, otolaryngologists, pulmonologists and urologists. Unidox Solutab ® is an original patented medicine, produced by the largest pharmaceutical company Astellas Pharma Europe. In Russian pharmacies the drug costs about 350 rubles.

Which is better, Doxycycline ® or Unidox Solutab ®?

Doxycycline ® is a semi-synthetic antibiotic that acts bacteriostatically. Active against gram+ and gram-aerobic infectants. The main advantage of the drug is that it provides stable and long-lasting therapeutic effect. The bioavailability of the antibiotic reaches 100%.

One capsule of Doxycycline ® contains 100 mg of doxycycline hydrochloride. Unidox Solutaba ® contains doxycycline monohydrate. Monohydrate contains a molecule of water, and hydrochloride contains a molecule of hydrogen chloride.

Hydrochloride irritates the esophagus, so Doxycycline must be taken with a sufficient amount of liquid. The Unidox analogue is absorbed in the stomach, and the branded drug is absorbed in the intestines. The latter rarely causes complications from gastrointestinal tract. After taking Doxycycline tooth enamel and dentin acquire a yellowish tint.

The difference between Doxycycline ® and Unidox Solutab ® is that the original antibiotic goes through several stages of purification before entering the pharmaceutical market, so it is considered safer than the generic and has a smaller list of contraindications and side effects.

Analogues of Unidox Solutab ® based on active ingredient

Bassado ® is a semi-synthetic tetracycline antibiotic that suppresses and slows down the growth and reproduction of pathogenic microorganisms. Bassado ® penetrates well into bacterial cells. Like all tetracyclines, the antibiotic inhibits the enzymatic activity of the flora of the gastrointestinal tract and is completely absorbed.

Bassado ® is contraindicated in porphyrin disease, severe liver failure and a reduced number of leukocytes. An antibiotic should not be prescribed in the 2nd and 3rd trimesters of pregnancy and lactation, as it can penetrate the hematoplacental barrier.

Vibramycin ® has a bacteriostatic effect due to inhibition of protein synthesis at the ribosome level. Vibramycin ® is active against gram+ and gram- pathogens, stable in the presence of strains resistant to penicillin and cephalosporin antibiotics. Vibramycin ® is effective in the treatment of such fatal dangerous diseases, like the plague, epidemic lymphadenitis, malignant carbuncle, brucellosis. When taking drugs, it is possible to develop hypersensitivity to ultraviolet.

Doxal ® prescribed for inflammation of the bronchi, lungs, infections urinary tract, amoebic dysentery, infectious jaundice, psittacosis and acne. Doxal ® forms insoluble complexes with calcium, which are deposited in enamel and dentin. An antibiotic may interfere correct formation bones and cartilage tissue in the fetus, therefore it is not prescribed to pregnant women (2nd and 3rd trimesters). With prolonged antibiotic therapy, the functions of the liver, urinary system and hematopoiesis should be monitored.

Doxycycline AKOS ® disrupts the connection of transport aminoacyl RNA with the 30S subunit of the ribosomal membrane. The antibiotic demonstrates high rates of effectiveness in the treatment of bronchitis, bronchogenic pneumonia, pyothorax, pyelonephritis, angiocholitis, furunculosis, legionellosis, tropical polypapilloma and tick-borne borreliosis. The drug causes complications from the gastrointestinal tract, nervous system, and hematopoietic organs. During use, a false increase in the level of dopamine, adrenaline and norepinephrine in the urine is possible.

Xedocin ® has high absorption, reaching 100% and is highly soluble in lipids. The drug is effective in the treatment of gonorrhea, syphilis, and uncomplicated infections urethra, traveler's diarrhea, leptospirosis and acne. The medicine is contraindicated in patients suffering from porphyrin disease and leukopenia.

The antibiotic is produced in Germany.

Monoclin ® presented on pharmaceutical market in the form of tablets, each containing 100 mg of doxycycline hydrochloride. An antibiotic is prescribed for infectious lesions lungs, organs of the reproductive and urinary systems, brucellosis, cholera, acne and chlamydial conjunctivitis. Monoclin ® is used in the treatment of syphilis if the patient is allergic to β-lactams.

Doxycycline Nycomed ® – semisynthetic tetracycline with a wide spectrum of action. At severe forms For purulent-septic diseases, intravenous administration of this drug is practiced. The antibiotic is widely used in gastroenterology, dermatology, infectology, otolaryngology, pulmonology and urology. The list of side effects includes papilloedema, vestibular disorders, morbilliform rash, Quincke's edema, anaphylatoxic reactions, thrush, dysbiosis.

Doxycycline Stada ® – an antimicrobial drug intended for systemic use.

Like all tetracycline antibiotics, it suppresses intestinal microflora.

When taking the drug, there is a risk of developing cross-resistance to penicillins and other tetracyclines. Doxycycline Stada ® is indicated for rare infectious and inflammatory infections (donovanosis, brucellosis, Whitmore disease) and for chronic disorder digestion, transport and absorption nutrients in the small intestine.

Ambroxol + Doxycycline ® represents combination drug, which not only has antimicrobial effect, but also stimulates motor function respiratory tract. Ambroxol ®, which is part of the antibiotic, is a metabolite of bromhexine and has an expectorant effect. Ambroxol ® thins sputum, but does not increase its volume. The drug is prescribed for inflammation of the bronchi, lungs, bronchial asthma and cystic fibrosis. Ambroxol ® has a pathogenetic effect on the process of inflammation in the nasal cavity, nasopharynx, larynx, trachea and bronchi.

Other analogues from the group of tetracyclines

Minolexin ®

Minolexin ® is a semi-synthetic drug that has a bacteriostatic effect. The antibiotic quickly penetrates the lipid layer and accumulates in the sebaceous glands.

The Unidox substitute Solutab ® , produced in the form of capsules, is well absorbed from the digestive tract. The antibacterial effect does not depend on food intake. The anti-inflammatory effect occurs faster than with Doxycycline ® . The main advantage of Minolexin ® is the absence of cross-resistance with other tetracycline antibiotics.

Minocycline ®

Minocycline ® was first introduced in the late 60s of the last century. IN modern medicine used in the treatment of rickettsiosis and amoebic dysentery. Minoclin refers to antimicrobial agents long acting. It is superior to other tetracyclines in spectrum antibacterial activity. The antibiotic is active against meningococci, mycoplasma pneumoniae, Haemophilus influenzae and pneumococci.

Since the early 1990s, Minocycline ® has been sold in Russian pharmacies under the brand name Minocin ®. Country of origin: United States of America . The drug is indicated for cystic fibrosis, persistent pulmonary hypertension and abscess pneumonia. The drug is suitable for patients on artificial ventilation lungs. In the early 2000s, the antibiotic disappeared from the pharmaceutical market, so the registration of the drug was not renewed.

Rondomycin ®

Rondomycin ® is synthesized from tetracycline. Available in capsule form. The daily dose of the drug should be divided into two doses. Doctors prescribe Rondomycin ® for bronchiectasis, catarrhal pneumonia, tonsillitis, shigellosis, breastfeeding, salpingo-oophoritis, pyothorax, osteomyelitis, .The antibiotic is used as preventive measures regarding complications of diseases viral etiology. The drug is contraindicated during breastfeeding and diabetes insipidus syndrome.

Chlamydia has a detrimental effect antibiotic drugs based on doxycycline - this is a proven scientific fact. This is why you can use tetracycline Unidox Solutab for chlamydia.

The antibiotic is active against a variety of gram-positive and gram-negative bacteria. Its action is aimed at damaging ribosomal membranes and destabilizing RNA synthesis.

Unidox Solutab is produced in the form of tablets for oral administration. The price of a package of medicine is 350-500 rubles (the price is indicated for 10 tablets of 100 mg each). The manufacturer of the antibiotic is B.V. Astellas Pharma Europe (Netherlands).

How does the antibiotic affect chlamydia?

Chlamydia is infection, the causative agent of which is the microorganism Chlamydia trachomatis. The microorganism is transmitted from person to person through unprotected sexual intercourse. Using barrier contraception the likelihood of transmitting the microorganism through sexual contact is minimal.

Chlamydia is quite dangerous pathology. At untimely treatment The disease develops complications such as pyelonephritis, endometritis, prostatitis, orchitis, and reactive arthritis. In women, chronic chlamydia can cause ectopic pregnancy.

To treat the disease, it is customary to use antibiotic drugs. Tetracycline antibiotics have proven themselves to be effective, including Unidox Solutab. The drug has a detrimental effect not only on chlamydia, but also on a number of other pathogenic microorganisms.

Doxycycline is absorbed from the gastrointestinal tract quite quickly. About 2 hours after taking the antibiotic, active substance already penetrates almost all tissues of the body (the only exception is cerebrospinal fluid). Antibiotic metabolites are excreted through the kidneys and gastrointestinal tract.

Unidox Solutab is active not only against chlamydia, but also against the following microorganisms:

  1. Gram-positive bacteria - listeria, streptococci, staphylococci.
  2. Gram-negative bacteria - salmonella, clostridium, gonorrhea, brucella, etc.
  3. Mycoplasma.
  4. Spirochetes.
  5. Rickettsia.

Of course, antibiotic therapy forms the basis of treatment. But recently, to get rid of chlamydia and other pathogenic microorganisms, dietary supplements have become widely used. plant based. Intoxic Plus has proven itself well.

The food additive is active against salmonella, chlamydia, roundworms, and pinworms. The drug can be used in the treatment of chlamydia and helminthiasis.

Instructions for use of the drug

Unidox Solutab tablets for chlamydia should be taken without chewing. However, it is allowed to crush the tablets into powder and mix with water. The optimal dosage of the product is 0.2 grams (the first day).

Starting from the second day of treatment, the dose is reduced to 0.1 grams. It is advisable to divide the daily dose into 2 doses on the first day of treatment. When treating gonorrhea and syphilis, the dosage is increased to 0.3 grams. Children weighing up to 50 kg should calculate the dosage based on the ratio of 0.04 grams per 1 kg of weight.

The duration of antibiotic use is selected according to individually. Usually the duration of treatment is 5-10 days. At chronic chlamydia Several courses of therapy may be prescribed.

Indications for the use of the antibiotic Unidox Solutab are:

  • Otitis, tonsillitis.
  • Tracheitis.
  • Lung abscess.
  • Chronic or acute bronchitis.
  • Farignitis.
  • Ureaplasmosis.
  • Chlamydia.
  • Gonorrhea.
  • Bacterial.
  • Pyelonephritis.
  • Urethritis.
  • Cystitis.
  • Endometritis.
  • Cholecystitis, cholera, diarrhea, gastroenterocolitis, yersiniosis.
  • Osteomyelitis.
  • Peritonitis.
  • Sepsis.
  • Trachoma.

It is also possible to use an antibiotic in treatment anthrax, whooping cough, malaria, ornithosis, leptospirosis, reckettsiosis, etc.

Contraindications and side effects

Unidox Solutab for chlamydia is strictly prohibited for use by children and patients who are allergic to the components of the drug. Strict contraindications are acute diseases liver and kidneys.

The list of contraindications also includes porphyria, pregnancy (any trimester), period breastfeeding. During therapeutic therapy it is strictly forbidden to use alcoholic drinks, Phenytoin, Carbamazepine and barbiturates.

Side effects:

  1. Nausea, vomiting, enterocolitis, abdominal pain, loss of appetite, stomatitis.
  2. Allergic and anaphylactic reactions.
  3. Kidney failure.
  4. Liver failure.
  5. Lack of potassium in the blood.
  6. Albuminuria.
  7. Increased plasma nitrogen levels.
  8. Hallucinations (extremely rare).
  9. Noise in ears.
  10. Increased fragility of bones and teeth.
  11. Changing the color of tooth enamel.
  12. Reduced blood pressure.
  13. Difficulty breathing.
  14. Tachycardia.
  15. Hyperemia.

If side effects occur, symptomatic treatment with gastric lavage, enterosorbents and antihistamines is indicated.