Dicynone for injection. How to take Dicinone for uterine bleeding Dicinone side effects

Dicinone (solution IV and IM 125 mg/ml 2 ml amp. N10) Slovenia Lek dd.

P N013946/02.MNN Etamzilat
Trade name Dicynone
Registration number P N013946/02
Registration date 12/12/2007
Cancellation date
Manufacturer: Lek d.d. - Slovenia

Packaging:
No. Packaging ND EAN
1 solution for intravenous and intramuscular injection 125 mg/ml 2 ml, ampoules (10) - blister packs (2) - cardboard packs ND 42-350-02 ~
2 solution for intravenous and intramuscular administration 125 mg/ml 2 ml, ampoules (10) - contour blister packs (2) - cardboard packs ND 42-350-07 ~
3 solution for intravenous and intramuscular administration 125 mg/ml 2 ml, ampoules (10) - contour blister packaging (5) - cardboard packs ND 42-350-07 3838957090563
4 solution for intravenous and intramuscular administration 125 mg/ml 2 ml, ampoules (10) - contour blister packaging (5) - cardboard packs ND 42-350-02 3838957090563
5 solution for intravenous and intramuscular administration 125 mg/ml 2 ml, ampoules (5) - contour blister packaging (2) - cardboard packs ND 42-350-07 ~
6 solution for intravenous and intramuscular administration 125 mg/ml 2 ml, ampoules (5) - contour blister packs (2) - cardboard packs ND 42-350-02 ~
7 solution for intravenous and intramuscular administration 125 mg/ml 2 ml, ampoules (5) - contour blister packaging (5) - cardboard packs ND 42-350-02 ~
8 solution for intravenous and intramuscular administration 125 mg/ml 2 ml, ampoules (5) - contour blister packaging (5) - cardboard packs ND 42-350-07 ~

Description (Vidal):

DICYNONE

Representation:
SANDOZ ATX code: B02BX01 Marketing authorization holder:
LEK d.d.,
etamsylate

Release form, composition and packaging

Tablets are white or almost white, round, biconvex. 1 tablet
etamsylate 250 mg

Excipients: anhydrous citric acid, corn starch, povidone K25, magnesium stearate, lactose.

10 pieces. - blisters (10) - cardboard packs.

The solution for intravenous and intramuscular administration is colorless, transparent. 1 ml 1 amp.
etamsylate 125 mg 250 mg

Excipients: sodium disulfite, water for injection, sodium bicarbonate (used in some cases to correct pH).

2 ml - ampoules (5) - blisters (2) - cardboard packs.
2 ml - ampoules (5) - blisters (5) - cardboard packs.
2 ml - ampoules (10) - blisters (2) - cardboard packs.
2 ml - ampoules (10) - blisters (5) - cardboard packs.

Clinical and pharmacological group: Hemostatic drug. Thromboplastin formation activator

Registration No.:
tab. 250 mg: 100 pcs. - P No. 013946/01, 11/26/07
solution for intravenous and intramuscular administration 250 mg/2 ml: amp. 10, 20, 25 or 50 pcs. - P No. 013946/02, 12.12.07
The description of the drug is based on the officially approved instructions for use and approved by the manufacturer for the 2009 edition.
Pharmacological action | Pharmacokinetics | Indications | Dosage regimen | Side effect | Contraindications | Pregnancy and lactation | special instructions| Overdose | Drug interactions| Terms of release from pharmacies | Storage conditions and expiration dates
pharmachologic effect

Hemostatic drug. The drug increases the formation of high molecular weight mucopolysaccharides in the walls of capillaries and increases the stability of capillaries, normalizes their permeability during pathological processes, improves microcirculation. It has a hemostatic effect, which is due to the activation of thromboplastin formation at the site of damage to small vessels. The drug stimulates the formation of blood coagulation factor III and normalizes platelet adhesion. The drug does not affect prothrombin time, does not have hypercoagulable properties and does not contribute to the formation of blood clots.

After intravenous administration, the drug begins to act within 5-15 minutes; maximum effect observed after 1 hour, duration of action is 4-6 hours.

Pharmacokinetics

Suction and distribution

After intravenous administration of the drug at a dose of 500 mg, Cmax is reached after 10 minutes and is 50 mcg/ml.

After oral administration, the drug is quickly and almost completely absorbed. After taking the drug at a dose of 50 mg, Cmax is reached after 4 hours and is 15 mcg/ml.

Etamzilate penetrates the placental barrier and is excreted breast milk.

Removal

About 72% of the administered dose is excreted unchanged through the kidneys during the first 24 hours.

After intravenous administration, T1/2 is about 2 hours; after oral administration, T1/2 is about 8 hours.

Indications

Prevention and treatment capillary bleeding of various etiologies:

- during and after surgical operations on all well-vascularized tissues in otorhinolaryngology, gynecology, obstetrics, urology, dentistry, ophthalmology and plastic surgery;

- hematuria, metrorrhagia, primary menorrhagia, menorrhagia in women with intrauterine contraceptives, nose bleed, bleeding gums;

- diabetic microangiopathy (hemorrhagic diabetic retinopathy, repeated retinal hemorrhages, hemophthalmos);

- intracranial hemorrhages in newborns and premature infants.

Dosage regimen

Pills

Optimal daily dose for adults is 10-20 mg/kg body weight, divided into 3-4 doses. In most cases, a single dose is 250-500 mg 3-4 times / In exceptional cases, a single dose can be increased to 750 mg 3-4 times /

For menorrhagia, 750-1000 mg/day is prescribed, starting from the 5th day of the expected menstruation until the 5th day of the next menstrual cycle.

IN postoperative period the drug is prescribed in a single dose of 250-500 mg every 6 hours until the risk of bleeding disappears.

Children are prescribed a daily dose of 10-15 mg/kg in 3-4 doses.

Solution for IM and IV injections

The optimal daily dose for adults is 10-20 mg/kg, divided into 3-4 IM or IV (slow) injections.

For adults undergoing surgical interventions, a prophylactic dose of 250-500 mg is administered intravenously or intramuscularly 1 hour before surgery. During surgery, 250-500 mg is administered intravenously; this dose can be repeated again. After surgery, 250-500 mg is administered every 6 hours until the risk of bleeding disappears.

For children, the daily dose is 10-15 mg/kg body weight, divided into 3-4 administrations.

In neonatology: Dicinone is administered intramuscularly or intravenously (slowly) at a dose of 12.5 mg/kg (0.1 ml = 12.5 mg). Treatment should begin within the first 2 hours after birth.

The solution for IM and IV injections can be used topically: a sterile swab or gauze pad is soaked in the solution and applied to the wound (skin graft, tooth extraction).

If Dicynone is mixed with saline, it should be administered immediately.

Side effect

From the central nervous system and peripheral nervous system: headache, dizziness, paresthesia of the lower extremities.

Dermatological reactions: facial skin hyperemia.

From the outside digestive system: nausea, heartburn, heaviness in the epigastric region.

From the outside of cardio-vascular system: decrease in systolic blood pressure.

Contraindications

- acute porphyria;

- hemoblastosis in children (lymphoblastic and myeloblastic leukemia, osteosarcoma);

- thrombosis;

- thromboembolism;

— increased sensitivity to the components of the drug and sodium sulfite.

The drug should be prescribed with caution in case of thrombosis, a history of thromboembolism, bleeding due to an overdose of anticoagulants.

Use during pregnancy and breastfeeding

Use during pregnancy is only possible in cases where potential benefit therapy for the mother exceeds possible risk for the fetus.

If necessary, prescribing the drug during lactation breast-feeding should be stopped.

special instructions

Before starting treatment, other causes of bleeding should be excluded.

1 tablet of Dicynone contains 60.5 mg of lactose (the maximum daily dose of lactose should not exceed 5 g). The drug should not be prescribed to patients with congenital glucose intolerance, lapp lactase deficiency (lactase deficiency in some peoples of the North) or glucose-galactose malabsorption syndrome.

The solution for intramuscular and intravenous administration is intended only for use in hospitals and clinics.

Impact on the ability to drive vehicles and operate machinery

No special precautions required.

Overdose

Data on overdose of the drug Dicinon are not provided.

Drug interactions

Administration of a dose of 10 mg/kg body weight 1 hour before the administration of dextrans prevents their antiplatelet effect. Administration of Dicynone after administration of dextrans does not have a hemostatic effect.

A combination with aminocaproic acid and menadione sodium bisulfite is possible.

Pharmaceutical interactions

Pharmaceutically incompatible (in the same syringe) with other drugs.

Incompatible with sodium bicarbonate injection and sodium lactate solution.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

The drug in the form of a solution for intramuscular and intravenous administration should be stored in a place protected from light, out of reach of children, at a temperature not exceeding 25°C. Shelf life - 5 years.

The drug in tablet form should be stored in a place protected from light and moisture, out of reach of children, at a temperature not exceeding 25°C. Shelf life - 5 years.

If staining appears, the injection solution should not be used.

Dicynone is a hemostatic drug, a means to prevent and stop bleeding.

The mechanism of action is due to the influence on the first stage of the hemostasis process (interaction between the endothelium and platelets). Suppresses the breakdown of mucopolysaccharides vascular wall(antihyaluronidase activity), and normalizes permeability in pathological processes. The medication acts hemostatically by increasing the rate of formation of the primary thrombus.

On this page you will find all the information about Dicynon: full instructions as applied to this medicine, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Dicinon tablets. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Hemostatic drug. Activator of thromboplastin formation.

Conditions for dispensing from pharmacies

Dispensed with a doctor's prescription.

Prices

How much does Dicynon cost? The average price in pharmacies is 430 rubles.

Release form and composition

The drug is available in tablet form, 250 mg (100 pieces per package) and in the form of an injection solution at a dosage of 2 ml in an ampoule (50 or 10 per package).

• The active substance is ethamsylate, 250 mg per tablet and 2 ml ampoule.

Additional substances are:

• for injections: injection water, sodium metabisulfite, sodium bicarbonate.
• for tablets: povidone, corn starch, citric acid, lactose, magnesium stearate.

Pharmacological effect

The active ingredient of Dicynone is ethamsylate.

The drug has a homeostatic effect (stops or reduces bleeding), which is due to the ability of the drug to activate the formation of thromboplastin (formed on initial stages coagulation process). The use of Dicynone allows you to increase the formation of mucopolysaccharides (protect protein fibers from injury) large mass in the walls of capillaries, normalize capillary permeability, increase their stability, improve microcirculation.

Dicinone does not have the ability to increase blood clotting and cause vasoconstriction, and does not contribute to the formation of blood clots. Dicinone begins to act 1-2 hours after oral administration and 5-15 minutes after injection. Therapeutic effect Dicynone is observed within 4-6 hours.

Indications for use

What does it help with? Dicynone is used to prevent and stop parenchymal and capillary bleeding in otolaryngology with surgical treatment(tonsillectomy, i.e. removal of tonsils, microsurgical operations on the ear, etc.).

The use of the drug is also indicated in the following cases:

1. In operative gynecology;
2. During surgical interventions in ophthalmology (keratoplasty, and treatment);
3. In dentistry during surgical interventions (removal of cysts, extraction (removal) of teeth);
4. In emergency surgery to stop intestinal and pulmonary hemorrhage, in neurology - with progressive ischemic stroke;
5. At hemorrhagic diathesis and diseases of the blood system.

Contraindications

• thromboembolism,
• acute porphyria,
• glucose-lactose deficiency,
• thrombosis,
• patient hypersensitivity to at least one of the components of the drug, as well as to sodium sulfite,
• hemoblastosis in children, including myeloblastic and lymphoblastic leukemia, osteosarcoma.

The drug is prescribed with caution if the patient has previously suffered thrombosis, as well as bleeding while taking anticoagulants.

Use during pregnancy and lactation

The use of the drug during pregnancy is permissible only in cases where the benefit of its use for the mother outweighs the risk possible complications for the fetus.

When prescribing Dicinon during lactation, breastfeeding should be temporarily stopped.

Instructions for use

The instructions for use indicate that Dicinon is available in the form of a solution for intravenous and intramuscular injections and in the form of tablets intended for oral administration. It's also possible local application Dicinone by applying a tampon soaked in the solution to the wound. One ampoule and one tablet contain 250 mg of ethamsylate.

Instructions for tablets:

1. The optimal daily dose for adults is 10-20 mg/kg body weight, divided into 3-4 doses. In most cases, a single dose is 250-500 mg 3-4 times a day. In exceptional cases, the single dose can be increased to 750 mg 3-4 times a day.
2. For menorrhagia, 750-1000 mg/day is prescribed, starting from the 5th day of the expected menstruation until the 5th day of the next menstrual cycle.
3. In the postoperative period, the drug is prescribed in a single dose of 250-500 mg every 6 hours until the risk of bleeding disappears.
4. Children are prescribed a daily dose of 10-15 mg/kg in 3-4 doses.

Solution for IM and IV injections:

1. The optimal daily dose for adults is 10-20 mg/kg, divided into 3-4 IM or IV (slow) injections.
2. For adults undergoing surgical interventions, a prophylactic dose of 250-500 mg is administered intravenously or intramuscularly 1 hour before surgery. During surgery, 250-500 mg is administered intravenously; this dose can be repeated again. After surgery, 250-500 mg is administered every 6 hours until the risk of bleeding disappears.
3. For children, the daily dose is 10-15 mg/kg body weight, divided into 3-4 administrations.
4. In neonatology: Dicinone is administered intramuscularly or intravenously (slowly) at a dose of 12.5 mg/kg (0.1 ml = 12.5 mg). Treatment should begin within the first 2 hours after birth.
5. If Dicynone is mixed with saline, it should be administered immediately.

Side effects

The use of Dicinon in some cases can cause the following side effects: heaviness in the epigastric region (upper part abdominal wall), heartburn, overflow of blood vessels in the face, headache, dizziness, numbness of the legs, allergic reactions, lowering blood pressure.

Overdose

special instructions

1. Before starting treatment, other causes of bleeding should be excluded.
2. If the solution for intramuscular and intravenous administration becomes stained, it should not be used.
3. The solution for intramuscular and intravenous administration is intended only for use in hospitals and clinics.
4. The solution for IM and IV injections can be used topically: a sterile swab or gauze pad is soaked in the solution and applied to the wound (for example, skin graft, tooth extraction).
5. One tablet of Dicynon contains 60.5 mg of lactose (the maximum daily dose of lactose should not exceed 5 g). The drug should not be prescribed to patients with congenital glucose intolerance, lapp lactase deficiency (lactase deficiency in some peoples of the North) or glucose-galactose malabsorption syndrome.

Drug interactions

1. The drug can be combined with aminocaproic acid and menadione sodium bisulfite.
2. Dicynone is also incompatible with sodium bicarbonate injection and sodium lactate solution.
3. In the form of a solution, the drug is pharmaceutically incompatible (in the same syringe) with other drugs.
4. Administration of a dose of 10 mg/kg body weight 1 hour before the administration of dextrans prevents their antiplatelet effect. Administration of Dicynone after administration of dextrans does not have a hemostatic effect.

Women are often concerned about uterine bleeding, which has different reasons. In the arsenal of doctors there is a large number of means to help cope with this pathology. Dicynone is one of the most popular, effective and inexpensive drugs.

Why does uterine bleeding occur?

The discharge of blood from the female genital organs, not programmed by nature, is an abnormal condition and requires treatment. There are many reasons for uterine bleeding. Therefore, a classification has been created of the main factors affecting the body of women that can cause bleeding from the uterus.

Conventionally, there are 2 main categories of reasons:

1. Pathologies arising from diseases and conditions that do not affect the reproductive system:
   • infections:
     • sepsis;
     • dysentery;
   • blood diseases:
     • vasculitis;
     • hemophilia;
   • metabolic disease;
   • pathologies in the functioning of the cardiovascular system;
   • cirrhosis of the liver.
2. Diseases, pathologies and conditions related to the reproductive system:
   • tumors (benign and malignant) of the uterus and/or ovaries;
   • ruptures of cysts and/or ovaries;
   • genital infections;
   • inflammatory processes of the uterus:
     • endometritis;
     • cervicitis;
     • erosion;
   • menopause;
   • pathologies during pregnancy;
   • period of puberty.

The most common vaginal/uterine bleeding occurs in menopause when a woman’s body is very susceptible to the influence of negative external factors.

Uterine bleeding is divided into dysfunctional and breakthrough. Any manifestation of bleeding from the uterus requires emergency measures aimed at stopping bleeding and identifying (with subsequent elimination/treatment) true reasons such a state.

Dicinon for uterine bleeding: effectiveness and feasibility

The primary pre-medical measures to stop uterine bleeding to prevent large blood loss are to ensure complete rest and use hemostatic agents (only if absolutely necessary).

Among medicines, capable of reducing the abundance bleeding, the most popular is Dicynon. It can be found in any pharmacy chain.

Dicynon is a scientific and pharmaceutical development of the famous company LEK (Slovenia). The drug is based on an active active substance etamsylate, which has the following properties:

• angioprotective;
• hemostatic;
• stimulating.

Etamsylate in the base of Dicynon promotes platelet formation, their aggregation and activity. The medicine helps in the formation of thromboplastin, which consequently reduces bleeding. Dicynone prevents the destruction of blood vessels and also helps reduce fragility, normalizing their permeability in various pathological processes. Blood microcirculation improves without thrombosis.

The mild hemostatic effect is noticeable within 15–30 minutes after taking the drug, and the highest peak of effectiveness is observed after 1–2 hours. The effect of the drug lasts no more than six hours, and then weakens over the next 24 hours.

The medicine is available in two forms: solution for intramuscular or intravenous internal administration and tablets. In pre-medical practice, a tablet drug is used. In other cases, the use of this medicine requires a special prescription from a doctor in a hospital setting.

Most effective method intravenous administration of Dicinone is considered to be used.

Composition and description of the drug Dicinon

As already mentioned, the main active ingredient in any form of release of the drug is ethamsylate. In tablets and injections, its amount is 250 mg.

The remaining components of tableted Dicynone are auxiliary:

• corn starch;
• lactose;
• lemon acid;
• magnesium stearate;
• Povidone K25.

The tablets are biconvex, white, with a breaking line. Packed in a blister of 10 units.

Solution for intramuscular and intravenous administration in its composition (except active substance) has the following additional components:

• sodium disulfide;
• sodium bicarbonate (to adjust pH levels);
• distilled water.

The drug is a colorless liquid, in 2 ml ampoules made of neutral transparent glass with special marks for proper opening. The break point is marked with colored paint. The ampoules are packaged in special blisters of 5 or 10 pieces.

When is the drug prescribed?

Any bleeding can be an indication for the use of Dicinon. However, most often this drug is used for pathological conditions when there is a danger of large blood loss. It can be the following types uterine bleeding:

• dysfunctional, when the ovaries malfunction;
• profuse, not accompanied by pain and caused by abortion, infection, fibroids;
• breakthrough, with hormonal imbalance or against the background of injury;
• hypotonic, with minimal uterine tone, usually after abortion or childbirth.

Use during pregnancy

However, during pregnancy, if bleeding from the genitals occurs, you should refrain from independent use Dicynone, since only a doctor can correctly assess the situation and decide on the advisability of taking it this drug.

The use of the drug during pregnancy is possible only when the potential benefits for the woman outweigh the possible risks for the unborn child. If it is necessary to use the drug during lactation, breastfeeding must be stopped.

Use in childhood

It is possible to use the drug in the treatment of uterine bleeding in children only in accordance with the doses prescribed by the doctor. In such cases, strict adjustments must be made in relation to the patient’s age and weight.

Contraindications and application features

There are a number of contraindications to the use of this medicine. Dicinon should not be used for the following diseases and conditions:

• thrombosis;
• thromboembolism;
• in children under 12 years of age;
• acute porphyria;
• hemorrhages and bleeding caused by exceeding the dose of anticoagulants;
• increased sensitivity of the body to the components of the drug.

Special conditions

The drug should be used with extreme caution to treat patients suffering from congenital lactose intolerance or Lapp lactose deficiency. It must be taken into account that the daily intake dose milk sugar should not exceed 5 g (1 tablet of medicine contains almost 60 mg of lactose).

You cannot use the drug and solutions of sodium bicarbonate and sodium lactate at the same time.

When using the medicine in injections, it should not be mixed with other drugs in the same syringe! It is prohibited to use Dicynon if a color tint appears in the solution!

Side effects

During therapy, side effects are possible, which disappear after discontinuation of the drug.

1. From the central and peripheral nervous systems may be observed:
   • headache;
   • dizziness;
   • numbness of the lower extremities.
2. From the gastrointestinal tract:
   • nausea;
   • heartburn;
   • heaviness in the stomach;
   • flatulence.
3. Allergy.
4. Reduced blood pressure.
5. Redness of the facial skin.

Mode of application

Using the drug without a prescription is possible only as an “ambulance” while awaiting qualified treatment. In this case, a single dose of Dicinon should not exceed 2 tablets (for adults).

In the future, the drug is prescribed by the attending physician if its use is considered appropriate. The duration of therapy depends on the effectiveness.

How to replace medicine

Dicynone has a number of analogues, which are often used in the treatment of uterine bleeding. These are hemostatic drugs that can be used to stop the flow of blood from the uterus.

More information about one of the dicinone analogues - tranexam:

Drug analogues - table

Photo gallery of analogues

Aminocaproic acid - quickly stops uterine bleeding. Quickly stops bleeding Immunin

Almost every woman, one or more times in her life, encounters problems such as bleeding, which are considered very life-threatening. The hemostatic drug Dicynon helps to cope with this problem; its indications for use may be different and depend on the situation.

Dicynone - composition

This medicine used to reduce or completely stop bleeding that has various origins. The drug is also used for prevention. The main active ingredient of Dicynon is ethamsylate, which can be activated when capillaries and small vessels are damaged, while accelerating coagulation and the formation of thromboplastin.

According to the instructions for the drug Dicinon, it comes in two forms:

• in tablets;
• in solution for injections.

Dicynone – tablets

When purchasing a medication, pay attention to the packaging of the drug Dicinon, the composition of the tablets and active ingredients, including in addition to etamsylate and others Excipients: lactose, corn starch, magnesium, stearate, citric acid, povidone K25. This medicine has proplatelet and angioprotective properties that promote the formation of platelets and stimulate their release from the bone marrow.

The tablets have White color and round, biconvex shape. The packaging is made of cardboard and should contain 10 blisters. There are two types of dosages

1. Children's, which contains 0.05 g of active substance.
2. Adult - it contains 0.25 g of ethamsylate.

Dicynone – ampoules

The auxiliary components in injection solutions are:

• sodium disulfide;
• distilled water;
• sodium bicarbonate.

When treated with Dicynon, injections are given by a nurse intramuscularly or intravenously only in the hospital. The ampoules contain 250 mg of ethamsylate, their volume is 2 ml and contains a 12.5% ​​solution. The packages are available in 2 types and differ in the number of medications they contain: 20 or 50 pieces. After administering the medicine by injection, it begins to act within 15 minutes.

Dicynon - indications

Dicinon is used for bleeding of any kind, because it is capable of:

• stabilize ascorbic acid;
• increase the amount of mucopolysaccharides (protecting the body from injury to white fibers);
• increase stability and normalize capillary permeability;
• reduce the formation of prostacyclin in blood vessels;
• restore pathological changes do not affect the hemostasis system.

When asking what indications for use the drug Dicinon has, it is worth noting any bleeding that may be caused by:

• surgical interventions;
• diabetic angiopathy or hemophthalmos;
• uterine dysfunction;
• injury;
• von Willebrand-Jurgens disease or
• thrombocytopathy and so on.

The following diseases are considered the main contraindications when using the drug:

• thrombosis or;
• glucose-lactose deficiency;
• osteosarcoma;
• myeloblastic or;
• porphyria, which is in the acute stage.

It would be better to stop taking the drug if bleeding occurs after an overdose of anticoagulants (Heparin, Phenindione, Warfarin). If your body is sensitive to ethamsylate, then Dicynon should not be taken. When using this medicine correctly, side effects does not occur, but sometimes patients still experience:

• heartburn;
• nausea;
• weakness;
• headache;
• hot flashes to the face;
• dizziness;
• decreased blood pressure;
• Itching and redness appear at the injection site.

The course of treatment averages from one to ten days. Before you start using medications, you should consult a specialist. Depending on your diagnosis, the doctor prescribes a form of the drug Dicinon; it can be used in several ways:

1. The tablets should be taken with meals and washed down big amount water.
2. Injections are given regardless of food intake.
3. Compresses soaked in the solution are applied to the wound at any time of the day.

In most cases, the medicine is taken:

• 1-2 tablets per day, and if necessary, increase the dose to 3 tablets;
• The daily dose of the drug for injections is 0.5 or 1 whole ampoule, with heavy bleeding the dose can be increased to 1.5.
• Before surgery, patients are given 2 tablets for prophylaxis (3 hours before) or 1 ampoule is administered intramuscularly (60 minutes before).
• during surgical intervention Dicynone is administered intravenously up to two ampoules at a time.

How to take Dicinon during heavy periods?

The drug Dicinon helps very well with menstruation, but you can take it after consulting a gynecologist. The specialist prescribes medications for patients to take in a course:

• 2 tablets three times a day;
• Start taking Dicinon 3-4 days before the expected date of your period;
• From the first day of the cycle, they drink it for another 5 days.

Most women are interested in the question of how to drink Dicinon during menstruation; the use of this drug can last 10 days over several cycles. This is done to consolidate the result and prevent bleeding in the future. They also take medications for prolonged menstruation: one tablet 3 times a day for a week.

Take the medicine Dicinon when uterine bleeding in the form of injections to quickly achieve the desired result. The dosage is one or two ampoules at a time, which are injected very slowly into a vein or muscle. Repeat this procedure every six hours until the threat to the body disappears and reoccurrence is prevented.

How to take Dicinon to delay menstruation?

Every woman at least once in her life dreamed of delaying the onset of her period for a while. The reasons may be different for everyone: a wedding, sports competitions, beach holiday and so on. In this case, the drug Dicinon will help you; its dosage depends on the person’s weight and individual characteristics body. You need to take it five days before the start of your cycle, four tablets per day.

Interfering with natural process body, a woman can cause a lot of side effects:

• numbness in the legs;
• stomach ache;
• allergies, which manifest as rashes and redness on the face.

How long can you take Dicynon?

When answering the popular question about how many days you can take Dicinon, it is worth considering various factors. For example, the cause of bleeding, desired result, patient health characteristics and methods of application. On average, treatment should not exceed 10 days. If there is a need to extend the course, then the dose should be gradually reduced.

During the period of bearing a child, women experience various diseases. They begin to be treated only after consulting a gynecologist. To him future mom must trust completely. During pregnancy, Dicinon tablets are prescribed, the use of which is possible in exceptional cases. Daily dosage is no more than 3 tablets, they are taken at regular intervals.

In the first trimester, it is better not to use Dicinon; indications for use during pregnancy are as follows:

• with placental or chorionic abruptions;
• to stop nosebleeds;
• when spotting from the vagina occurs.

Dicynon - analogues

The hemostatic drug Dicynon produces pharmaceutical company Lek, which is located in Slovenia. In the CIS countries, the most common analogues are the following drugs:

1. Tranexam is a hemostatic agent in which the main active ingredient is tranexamic acid. The drug has anti-inflammatory and anti-allergenic effects.
2. Etamzilat (or Etamzilat-Verein)– used in gynecology and dentistry for the treatment of capillary, pulmonary or intestinal bleeding, after surgery.
3. Vikasol– water soluble synthetic drug, which is an analogue of vitamin K. It is widely used by surgeons and gynecologists to treat bleeding, and is approved for pregnant women and children. The medicine is dangerous in case of overdose.

Currently, in pharmacies you can find a huge number of medicines and drugs that include an ingredient such as etamsylate. These include: Ethamsylate, Impedil, Altodor, Cyclonamin, Aglumin, Dicynene. These medications are prescribed by a specialist in the same dosage as Dicynon and act similarly.

Dicynone has been used for many years in different areas medicine as a preventive measure and as a " ambulance"If bleeding occurs. These tablets effectively strengthen the walls of blood vessels, stop capillary and parenchymal bleeding, and also improve microcirculation, reduce the degree of capillary permeability, and accelerate the process of blood clotting. The main active ingredient of the tablets accelerates platelet maturation in bone marrow, activates the third coagulation factor in blood vessels.

The principle of action of Dicinon tablets

The main active component of Dicynon is ethamsylate. This substance has a hemostatic effect, that is, it reduces or completely stops bleeding. When damaged small vessels, the drug activates and forms thromboplastin in the blood, which is necessary to start coagulation processes.

• Thromboembolism
• Hemoblastosis in children
• Acute porphyria
• Hypersensitivity to sodium sulfide and other components of the tablets
• If you have carbohydrate intolerance, you should definitely consult your doctor.

The tablets do not have any effect on a person's reaction, so there are no contraindications for those people who administer vehicles or work with various mechanisms.

Side effects of the drug

The most common negative ones are:

• my head is spinning
• headaches
• nausea
• facial redness
• loss of sensation in the legs
• skin rashes
• stomach ache

In addition, severe leukopenia appears in those who suffer from acute lymphatic and myeloid leukemia when they are prescribed a drug to prevent bleeding. All of the above effects occur in a mild form and are observed quite rarely.

So, Dicinon tablets are prescribed to both adults and children. The medicine reduces internal and external bleeding and accelerates the blood clotting process.

Feb 24, 2017 Violetta Doctor