What are diphenhydramine injections for? Diphenhydramine: what it helps with, instructions for use, analogues. Basic physical and chemical properties. Diphenhydramine: instructions for use of tablets and solution

Diphenhydramine

About the drug:

Provides antihistamine, local anesthetic, antiallergic, antiemetic, hypnotic effect. Blocks histamine H1 receptors and eliminates the effects of histamine. Prevents or reduces smooth muscle spasms caused by histamine, tissue swelling, itching and hyperemia, increases capillary permeability.

Indications and dosage:

Indications for use:

Treatment of allergic reactions such as hay fever, urticaria, contact dermatitis, angioedema, serum sickness, eczema, erythema multiforme exudative, hemorrhagic vasculitis, itchy skin, vasomotor rhinitis, acute iridocyclitis, respiratory allergies. At allergic diseases eye (conjunctivitis).

Diphenhydramine is used for the treatment and prevention of allergic complications in order to reduce the side effects from taking medications, when transfusion of blood substitutes or blood. Used for chorea, Meniere's disease, air and sea sickness. For insomnia, neurosis, neurasthenia, it is used as a sedative and hypnotic drug.

Mode of application:

Inside, with a small amount of water. Adults and children over 12 years of age are prescribed 0.05 g of Diphenhydramine 1-3 times a day. Duration of treatment is 10-15 days. As a sleeping pill and sedative, the drug is used at a dose of 0.05 g 30 minutes before bedtime. Maximum doses for adults: single dose - 0.1 g; daily - 0.25 g. For children from 6 to 12 years old, the drug is prescribed 0.025 g (1/2 tablet containing 0.05 g) of diphenhydramine hydrochloride 1-3 times a day. Duration of treatment is 5-7 days.

Overdose:

In case of overdose, dry mouth, difficulty breathing, facial flushing, persistent mydriasis, excitation or depression of the central nervous system, arrhythmia, tachycardia, respiratory depression and of cardio-vascular system, confusion; depression, in children - the development of seizures. The development of rhabdomyolysis after an overdose of diphenylhydramine hydrochloride is known.

To treat an overdose, it is necessary to rinse the stomach, induce vomiting, take Activated carbon, carry out symptomatic and supportive therapy. In this case, it is necessary to carefully monitor breathing and blood pressure levels. Give an intravenous drip administration plasma replacement fluids, oxygen therapy.

The use of analeptics and epinephrine is prohibited. In case of overdose of diphenylhydramine hydrochloride, physostigmine (0.02-0.06 mg/kg intravenously) can be prescribed as an antidote. If anticholinergic symptoms increase, then several times. In cases of physostigmine overdose, atropine is recommended.

Side effects:

The following adverse reactions are possible: general weakness, insomnia, dizziness, drowsiness, headache, decreased speed of psychomotor reaction, increased excitability(especially in children), impaired coordination of movements, irritability, blurred vision, dilated pupils, tinnitus, photosensitivity, dry eyes. Frequent, difficult urination, urinary retention, thickening of bronchial secretions and difficulty in sputum separation, arterial hypotension are also possible.

The gastrointestinal tract may respond with rapid numbness of the oral mucosa, anorexia, dry mouth, nausea, constipation, vomiting, and diarrhea.

Rarely - hemolytic jaundice, agranulocytosis, thrombocytopenia, early menstruation, skin rash, urticaria, anaphylactic shock.

Very rarely - convulsions, increased intraocular pressure, contact dermatitis.

Contraindications:

Hypersensitivity to the components of the drug or antihistamines, pheochromocytoma, asthma attack, epilepsy, congenital long QT syndrome or prolonged use of drugs that prolong the QT interval, childhood up to 6 years, breastfeeding period.

Restrictions on use: prostatic hyperplasia, closed angle glaucoma, stenosing peptic ulcer duodenum and stomach, cervical stenosis Bladder, heart rhythm disturbances, bradycardia, pregnancy.

Interaction with other drugs and alcohol:

• Enhances the effect of central nervous system depressants and ethanol: tranquilizers, analgesics, neuroleptics, sleeping pills, narcotics.
• Monoamine oxidase inhibitors enhance the anticholinergic activity of Diphenhydramine. Incompatible with psychostimulants.
• When treating poisoning, it reduces the effectiveness of apomorphine as an emetic.
• Enhances anticholinergic effects medicines with anticholinergic activity.
• It should not be administered together with drugs containing diphenylhydramine hydrochloride.
• Can lead to increased intraocular pressure in glaucoma joint use diphenhydramine with tricyclic antidepressants.

Diphenhydramine affects the psychomotor reactions of the body, so the drug should not be taken while working with vehicles and other mechanisms.

Exposure to UV radiation and consumption of alcoholic beverages should be avoided during treatment with the drug.

Composition and properties:

1 tablet contains: diphenhydramine hydrochloride (diphenhydramine) 0.05 g or 0.1 g; Excipients: potato starch, lactose, talc, calcium stearate.

Release form: pills. In contour packs without blister packs, 10 tablets each. In packs. 3 blisters per pack. 10 tablets in blisters.

pharmachologic effect:

It has an antihistamine, local anesthetic, antiallergic, antiemetic, and hypnotic effect. Blocks histamine H1 receptors and eliminates the effects of histamine. Prevents or reduces smooth muscle spasms caused by histamine, tissue swelling, itching and hyperemia, increases capillary permeability. Antagonism with histamine occurs in inflammation and allergy in relation to local vascular reactions compared to systemic reactions, i.e. decrease in blood pressure. Calls local anesthesia(when taken, a short-term sensation of numbness of the oral mucosa occurs), blocks cholinergic receptors of the autonomic ganglia (reduces blood pressure), has an antispasmodic effect. Inhibits central cholinergic structures and blocks H3 histamine receptors in the brain. It has a hypnotic, sedative and antiemetic effect. It is very effective for bronchospasm caused by a histamine liberator, and to a lesser extent for allergic bronchospasm. At bronchial asthma is inactive and is used in combination with ephedrine, theophylline, and other bronchodilators.

Photo of the drug

Latin name: Dimedrol

ATX code: R06AA02

Active substance: Diphenhydramine

Analogues: Kalmaben, Dramina

Manufacturer: OJSC "Kiev Vitamin Plant" (Ukraine), Darnitsa (Ukraine), Galichfarm (Ukraine), Dalkhimfarm (Russia), Biosynthesis (Russia), Uralbiopharm (Russia)

Description is valid on: 28.09.17

Diphenhydramine belongs to the very first generation of antihistamines and is included in the list of the most important and vital medical substances. Diphenhydramine ( international name Diphenhydramine) is a finely crystalline White powder, which tastes bitter and causes numbness in the receptors of the tongue. Very easily soluble in alcohol, water and chloroform, practically insoluble in ether.

Active substance

Diphenhydramine.

Release form and composition

The drug is produced in the form of tablets of 20, 30 and 50 mg, suppositories, gel, sticks and pencils. Diphenhydramine is also produced in 1 ml ampoules and syringe tubes, in the form of 1% solutions for injection. The drug in ampoules is a frequently used pain reliever.

Indications for use

Diphenhydramine in ampoules, tablets and other forms of release is indicated in the treatment of the following diseases:

• Urticaria, hay fever, hay fever, serum sickness, vasomotor rhinitis, hemorrhagic vasculitis, allergic conjunctivitis, pruritic dermatosis, acute iridocyclitis.
• For allergic complications arising from drug therapy, as well as transfusion of blood substitute fluids and blood products.
• IN complex therapy For effective treatment radiation sickness, anaphylactic shock.
• For extensive complex injuries of soft tissues and skin.
• For complex therapy of stomach ulcers, bronchial asthma, hyperacid gastritis.

Diphenhydramine injections are used as premedication and for local anesthesia in patients with a history of allergic reactions to various anesthetics. Effective use of injections in treatment colds, Meniere's syndrome, sea and air sickness, vomiting, sleep disorders, Parkinson's disease.

Contraindications

Diphenhydramine tablets and injections are strictly contraindicated in patients with hypersensitivity to their components, prostate hypertrophy, stenosing gastric and duodenal ulcers.

Prescribing Diphenhydramine to children during the neonatal period or premature babies is strictly prohibited. This drug should also not be used for angle-closure glaucoma or pyloroduodenal obstruction. Diphenhydramine is not prescribed to children and adults for bronchial asthma and bladder stenosis. For pregnant women, the drug can only be prescribed as an antiemetic.

Instructions for use Diphenhydramine (method and dosage)

For adults Diphenhydramine is prescribed to be taken 30-50 mg one to three times a day. The therapeutic course lasts 10-15 days.

As a sleeping pill and sedative the drug is prescribed 50 mg in the evening, 20-30 minutes before bedtime, alone or in combination with other sleeping pills.

For the treatment of parkinsonism treatment is carried out according to a special scheme: at the beginning of the course, three times a day, 25 mg, with gradual increase dosages up to 50 mg taken four times a day.

Injections Diphenhydramine is administered intramuscularly, 1-5 ml. Adults and children over fifteen years of age maximum daily dose is 15 ml of a 1% solution, and the maximum single dose is 5 ml of a 1% solution.

Children from two to six years old Diphenhydramine is prescribed in a dose of 12.5-25 mg per day. For children aged six to twelve years, the recommended dose is 25-50 mg every six to eight hours.

Side effects

The use of Diphenhydramine in ampoules and tablets can cause the following side effects:

• Hematopoietic and cardiovascular system - uncontrolled hypotension, tachycardia, extrasystole, thrombocytopenia, hemolytic anemia, agranulocytosis.
• Nervous system – fatigue, drowsiness, weakness, decreased attention, nervousness, dizziness, euphoria, paresthesia, tremor, confusion, excitability, visual impairment, diplopia, convulsions, tinnitus, neuritis.
• Digestive system - dry mouth, anorexia, nausea, diarrhea or constipation, vomiting, epigastric distress.
• Respiratory systems - dry nasopharyngeal mucosa, difficulty breathing, thickening of bronchial secretions.

The drug can cause photosensitivity, sweating, various allergic reactions, and chills.

Diphenhydramine in ampoules, tablets and other medicinal forms is strictly prohibited from taking against the background alcohol intoxication. Alcoholic drinks are prohibited during treatment with this drug, since even a small combination of the drug and alcohol significantly increases the state of intoxication, and high dose The drug can cause severe delirium tremens and complex psychosis.

Overdose

An overdose of the drug can lead to severe consequences and even death in children.

Analogues

Kalmaben, Dramina.

pharmachologic effect

Diphenhydramine is one of those antihistamines that actively block H1 receptors, eliminating histamine effects mediated by this type of receptor. Prevents or reduces histamine-induced increase in the permeability of capillary walls, eliminates smooth muscle spasms, hyperemia, tissue swelling and itching.

IN moderate degree blocks cholinergic receptors of the autonomic nerve nodes, which provides antispasmodic and local anesthetic effects. Blocks H3 receptors in the brain, thereby inhibiting cholinergic central structures. IN medical practice The combination of analgin with diphenhydramine is widely used as an effective antipyretic and analgesic.

special instructions

Diphenhydramine should be prescribed with extreme caution to patients with hyperthyroidism, diseases of the cardiovascular system, increased intraocular pressure. The drug should be prescribed with caution to children and elderly people, as well as to those working in areas where increased concentration is required.

During pregnancy and breastfeeding

Prescribed with caution during pregnancy and lactation.

In childhood

Contraindicated: children under 7 months.

In old age

Information is absent.

Drug interactions

The drug is used in combination with other medicines to enhance therapeutic action. To relieve heat and fever, the most effective injections are those that combine Analgin with Diphenhydramine, for which both drugs are combined in one syringe. It is prohibited to use the mixture more than once for six to eight hours. Otherwise, Analgin with Diphenhydramine may cause severe side effects.

Conditions for dispensing from pharmacies

Dispensed by prescription.

Storage conditions and periods

Store in a place protected from light, out of reach of children, at a temperature not exceeding 30 °C. Shelf life: 5 years.

Price in pharmacies

The price of Diphenhydramine starts from 10 rubles. for 1 package.

Attention!

The description posted on this page is a simplified version of the official version of the annotation for the drug. The information is provided for informational purposes only and does not constitute a guide for self-medication. Before using the medicine, you must consult a specialist and read the instructions approved by the manufacturer.

1 ml of solution contains

active substance: diphenhydramine hydrochloride in terms of 100% substance 10 mg,

excipient: water for injection.

Description

Transparent colorless liquid.

Pharmacotherapeutic group

Systemic antihistamines. Aminoalkyl ethers. Diphenhydramine.

ATX code R06AA02

Pharmacological properties"type="checkbox">

Pharmacological properties

Pharmacokinetics

Plasma protein binding – 98-99%. Most of it is metabolized in the liver, a smaller part is excreted unchanged in the urine within 24 hours. The half-life (T1/2) is 1-4 hours. It is well distributed in the body and penetrates the blood-brain barrier.
Metabolized mainly in the liver by hydroxylation and conjugation to glucuronides; biotransformation products are eliminated in urine. Excreted in mother's milk and may cause sedation in children infancy. Maximum activity develops after 1 hour, duration of action is from 4 to 6 hours.

Pharmacodynamics

A first generation H1 histamine receptor blocker eliminates the effects of histamine that occur through this type of receptor. The effect on the central nervous system is due to the blockade of H3 histamine receptors in the brain and inhibition of central cholinergic structures. It has pronounced antihistamine activity, reduces or prevents smooth muscle spasms caused by histamine, increased capillary permeability, tissue swelling, itching and hyperemia. Causes the effect of local anesthesia (when taken orally, a short-term numbness of the mucous membranes of the oral cavity occurs), blocks cholinergic receptors of the ganglia (reduces blood pressure) and the central nervous system, has sedative, hypnotic, antiparkinsonian and antiemetic effects. Antagonism with histamine manifests itself to a greater extent in relation to local vascular reactions during inflammation and allergies than to systemic ones, i.e. lowering blood pressure. However, when administered parenterally to patients with a deficiency of circulating blood volume, a decrease in blood pressure and an increase in existing hypotension due to the ganglion-blocking effect are possible. In people with local brain damage and epilepsy, it activates (even in low doses) epileptic discharges on the EEG and can provoke epileptic seizure. It is more effective for bronchospasm caused by histamine liberators (tubocurarine, morphine), and to a lesser extent for bronchospasm of an allergic nature. Sedative and hypnotic effects are more pronounced with repeated doses.

Indications for use

Anaphylactic shock, urticaria, hay fever, angioedema, allergic conjunctivitis, drug-related allergic reactions

Hemorrhagic vasculitis (capillary toxicosis)

Serum sickness

Pruritic dermatoses, itching

Meniere's disease

Polymorphic exudative erythema

Postoperative vomiting

Directions for use and doses

The drug is prescribed to adults intramuscularly and intravenously. The drug should not be administered subcutaneously due to its irritating effect. When administered intramuscularly, a single dose is 10-50 mg (1-5 ml), the maximum single dose is 50 mg (5 ml), the highest daily dose is 150 mg (15 ml). The drug is administered intravenously in a dose of 20-50 mg (2-5 ml) of Diphenhydramine in 100 ml of 0.9% sodium chloride solution. The duration of treatment depends on the achieved effect and tolerability of the drug.

Side effects"type="checkbox">

Side effects

From the outside nervous system and sensory organs: general weakness, fatigue, sedative effect, decreased attention, dizziness, drowsiness, headache, impaired coordination of movements, decreased speed of psychomotor reactions, anxiety, increased excitability, fear of death, irritability, nervousness, insomnia, euphoria, confusion, tremor, neuritis, convulsions, paresthesia, dilated pupils, increased intraocular pressure, blurred vision, diplopia, acute labyrinthitis, tinnitus. In patients with local brain lesions or epilepsy, convulsive discharges on the EEG are activated (even when using low doses of Diphenhydramine) and the drug can provoke an epileptic attack.
From the cardiovascular system: arterial hypotension, palpitations, tachycardia, extrasystole.
From the blood system: agranulocytosis, thrombocytopenia, hemolytic anemia.
From the outside digestive tract: dry mouth, short-term numbness of the oral mucosa, anorexia, nausea, pain in the epigastric region, vomiting, diarrhea, constipation.
From the outside genitourinary system: frequent and/or difficulty urinating, urinary retention, early menstruation.

From the respiratory system: dryness of the mucous membrane of the nose and throat, nasal congestion, thickening of bronchial secretions, a feeling of constriction in the chest, difficulty breathing, shortness of breath.
From the skin and its derivatives: hyperemia, itching, polymorphic rashes, cyanosis of the skin and mucous membranes.

Allergic reactions: rash, urticaria, anaphylactic shock.

Reactions at the injection site: local necrosis after subcutaneous and intradermal administration.
Other: increased sweating, chills, fever, hyperthermic syndrome, photosensitivity.

Contraindications

Angle-closure glaucoma is included in UTI even in Kazakhstan

Prostatic hyperplasia

Stenosing gastric ulcer and duodenum

Bladder neck stenosis

Epilepsy

Bronchial asthma

Pregnancy and lactation

Hypersensitivity to the drug

Children's and adolescence up to 18 years old

Pheochromocytoma

Congenital long QT syndrome or long-term use drugs that can prolong the QT interval

Bradycardia

Heart rhythm disturbance

Porphyria

Drug interactions"type="checkbox">

Drug interactions

Diphenhydramine potentiates the effects of anesthetics, hypnotics, sedatives, narcotic analgesics and local anesthetics. When used with tricyclic antidepressants, an increased anticholinergic and inhibitory effect on the central nervous system is possible. There may be a risk of developing seizures when used with analeptics. The simultaneous use of MAO inhibitors and Diphenhydramine can lead to an increase in blood pressure and also affect the central nervous and respiratory system. Using Diphenhydramine with antihypertensive drugs may increase feelings of fatigue. The drug enhances the effect of ethanol and reduces the effectiveness of apomorphine as an emetic in the treatment of poisoning. It should not be prescribed simultaneously with drugs containing Diphenhydramine, including for topical use.

Incompatibility. Do not mix with other medications in the same container. Use only recommended solvent.

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special instructions

Not recommended for subcutaneous administration. Since Diphenhydramine has an atropine-like effect, it should be used with caution in patients with recent respiratory diseases in the anamnesis (including asthma), this is in the anamnesis, I’m not now specific disease increased intraocular pressure, hyperthyroidism, diseases of the cardiovascular system, arterial hypotension. May worsen the course of obstructive pulmonary diseases, serious illnesses cardiovascular system, ileus, obstruction condition biliary tract. Diphenhydramine can cause lethargy, as well as cause agitation, hallucinations, and convulsions, especially in overdose. Use with caution in patients over 60 years of age due to the greater likelihood of dizziness, sedation and hypotension.

Use with caution in patients with impaired liver and kidney function.
During treatment, UV radiation and alcohol consumption should be avoided. Patients should inform their doctor about the use of this drug: the antiemetic effect may make it difficult to diagnose appendicitis and recognize symptoms of overdose with other drugs.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

Since Diphenhydramine has a sedative and hypnotic effects, during treatment with the drug you should refrain from potentially dangerous species activities that require increased attention and speed of psychomotor reactions.

Each drug has specific indications for use. Often, drugs are used by patients without medical intervention. Often such cases end in complications and the addition of additional unpleasant symptoms. This is why it is so important to consult a doctor for therapy and receive individual recommendations.

Today's article will introduce you to a drug called Diphenhydramine. Find out what it helps with and in what situations it is necessary to use it. It is also worth mentioning the compatibility of this medicine with other drugs.

Description of the drug: release form, cost and composition

Produced in different forms medication "Diphenhydramine". At the pharmacy you can buy tablets and injection solution. Both versions of the drug are sold only as prescribed by a doctor. To buy the drug, you must have a prescription signed and stamped by a doctor. The drug "Diphenhydramine" has a fairly affordable price. Tablets of 10 pieces cost about 20 rubles. A package of injections can be purchased for 30 rubles.

The medicine contains active substance diphenhydramine. One injection ampoule contains 1 milliliter of solution, which contains 0.01 grams of the main component. The tablet contains 0.05 grams of this substance. So, you already know in what form and composition Diphenhydramine is produced. Its price also became known. Remember that before using the drug you must read the instructions.

"Diphenhydramine": indications prescribed in the instructions

If you read the annotation, you will find out that the drug has antihistamine, sedative and hypnotic effects. The last two qualities are often considered side effects from application. But doctors use them when prescribing the drug for certain pathologies. The instructions state the following readings to use the medicine:

• allergy of different origins(hay fever, urticaria, allergic dermatoses, Quincke's edema);
• serum sickness;
• stomach and intestinal ulcers;
• vomiting caused seasickness or toxicosis of pregnant women;
• Meniere's syndrome;
• radiation sickness;
• parkinsonism.

Scope of application: what does the medicine help with?

You already know in what situations the instructions recommend using the medicine "Diphenhydramine". What else can this medication help with? If you go deeper into medical use drug, you can find out that the range of its uses is quite wide.

"Diphenhydramine" is used in allergology to eliminate acute reactions that require urgent intervention. The drug can relieve different types allergies: from a common runny nose and skin rash to severe edema, bronchospasm, or laryngospasm. The medication acts on the central nervous system. It is used to eliminate spasm of smooth muscles. The drug is prescribed for increased capillary permeability. Due to its sedative effect, Diphenhydramine is used for increased excitability. The medication is used to treat bronchial asthma and similar diseases respiratory tract. It can be used to easily remove white fever. Very often, the drug "Diphenhydramine" is combined with other medications. Let's take a closer look at the use of antihistamines.

Allergy treatment

If you ask someone: “What does Diphenhydramine help with?”, the most likely answer will be: allergies. Indeed, this medication was originally valued for its antihistamine properties. The drug can eliminate even severe allergic reaction. It is used for intolerance to certain foods ( food allergies). Diphenhydramine is prescribed when an unexpected reaction to some medicinal product. Often it is so strong that a person changes in a matter of seconds: swelling appears, the face turns red, breathing and speech become difficult. The use of Diphenhydramine in such situations is justified and advisable. The medicine blocks histamine receptors, reduces the severity of inflammatory process, eliminates swelling. The maximum effect occurs within a few minutes and lasts for 12 hours.

The dosage of the medication is always determined individually. For adult patients, a single dose ranges from 1 to 5 milliliters of solution. For chronic allergies, it is recommended to use minimal doses. An acute reaction requires administration of the maximum amount of the drug. The tablets are prescribed by doctors in a volume of ½-1 pill. The frequency of use is 1-3 times a day. The duration of treatment should not exceed two weeks.

White fever

Very often in medicine the combination of “Analgin” and “Diphenhydramine” is used. For fever, this remedy is considered the most effective. Also, an antispasmodic is necessarily added to this composition. Despite the fact that Diphenhydramine has a smooth muscle relaxing effect, this is not enough. The action is due to its components:

• "Analgin" reduces body temperature and has an analgesic effect;
• "Diphenhydramine" eliminates the possibility of allergies, soothes and relaxes;
• “No-Spa” or any other antispasmodic affects the muscles and blood vessels, normalizing their function and relieving tension.

The drugs "Analgin" and "Diphenhydramine" for fever are necessary when other antipyretics are powerless. In such situations, a person’s extremities often become cold: arms and legs. Less commonly, chills may occur. The thermometer level crosses the border at 38-39 degrees, and continues to rise, despite the use of antipyretic drugs. How to properly give a Diphenhydramine injection with Analgin? The dosage of each medication is determined by the age of the patient.

• For adults, no more than 100 milligrams of Diphenhydramine and one gram of Analgin are administered per injection.
• The drugs “Analgin” and “Diphenhydramine” are prescribed to the child according to age. The daily amount of drugs is calculated using the formula 10 mg of Analgin + 0.41 mg of Diphenhydramine for each kilogram of body weight.

Please note the restrictions

Like any medicine, Diphenhydramine has its contraindications. It is not used if you are allergic to the main active ingredient. It is prohibited to use the medicine for epilepsy, prostate adenoma, and closed-angle glaucoma. If there is a suspicion of stenosis of the bladder neck or digestive tract, then it is necessary to conduct an examination before using the medication. When prescribing a drug, the doctor can give individual recommendations, in connection with which it will be necessary to replace the drug with an alternative one. Do not use Diphenhydramine on your own. Due to the fact that the drug is not sold without a prescription, you most likely will not be able to do this. Those outlets, online pharmacies and underground bases that offer this medicine on sale - they all do illegal activities and they may sell you a fake.

Diphenhydramine and alcohol

Quite often you can hear about the use of this medication With alcoholic drinks. In this way, the consumer tries to achieve hallucinations, relax, and enter euphoria. It’s worth saying right away that all this is not only dangerous to health. Such experiments may end fatal. That is why, recently, Diphenhydramine has become sold exclusively as prescribed by a doctor.

If you use Diphenhydramine for allergies, then during treatment you need to give up any alcohol, even beer. Combination chemical substances in one organism entails Negative consequences from the digestive tract. Irritation of the gastric walls can result in gastritis or ulcers. The drug, together with ethanol, has a detrimental effect on the liver and intestinal function. With this combination, a person experiences lethargy, drowsiness, and decreased arterial pressure, shortness of breath and tachycardia appear. There is a high probability of intoxication and the use of four tablets of the drug leads to death!

"Diphenhydramine" with other drugs

As has already become known, the drug is often used with Analgin. It is also combined with other antipyretics: Paracetamol, Ibuprofen. But this combination is used less often. “Diphenhydramine” combines well with antispasmodics: “No-Shpoy”, “Drotaverine”, “Papaverine” and so on. Acceptable to use antihistamine with sorbents, antiviral, anti-inflammatory compounds and antibiotics. Separately considered the following types combinations.

1. The drug enhances the effectiveness of medications that affect the functioning of the central nervous system.
2. Agents that inhibit monoamine oxidase can enhance the clouding and sedative effect of the drug.
3. The use of psychostimulants causes an antagonistic interaction.
4. "Diphenhydramine" reduces the effect of drugs used in case of poisoning to induce vomiting.

If you use any heart medications, sleeping pills, tranquilizers, or narcotic medications, then the possibility of combination with Diphenhydramine should be considered individually.

Side effects

The medicine "Diphenhydramine", no matter what you take it for, can cause adverse reactions. If these occur, you must stop using the medication and immediately consult a doctor. Among negative actions The following medications are noted:

• drowsiness, dizziness, weakness, clouding of consciousness, fainting;
• tremor, euphoria, convulsions, insomnia, mental agitation;
• increased viscosity of bronchial mucus, respiratory distress, dry mouth;
• thrombocytopenia, hemolytic anemia;
• decreased blood pressure, decreased urination;
• skin itching, rash, swelling.

Summarize

From the article you were able to learn about the features of using the drug "Diphenhydramine". As it turns out, it is often used in medicine. But to prescribe, the patient must have certain indications. Do not self-medicate. Contact your doctors for qualified assistance. Best wishes!

Name

Diphenhydramine ampoules

Release form

injection solution 10 mg/ml

INN

Diphenhydramine / Diphenhydramine.

ATX code: R06AA02.
Composition

1 ml of solution contains

Active substances

10 mg diphenhydramine (diphenhydramine).
Pharmacotherapeutic group

H1-antihistamines. Sedatives and hypnotics.
pharmachologic effect
Pharmacodynamics

It has antihistamine, antiallergic, antiemetic, hypnotic, and local anesthetic effects. Blocks histamine H1 receptors and eliminates the effects of histamine mediated through this type of receptor. Reduces or prevents histamine-induced smooth muscle spasms, increased capillary permeability, tissue swelling, itching and hyperemia. Antagonism with histamine manifests itself to a greater extent in relation to local vascular reactions during inflammation and allergies compared to systemic ones, i.e. decrease in blood pressure. Calls local anesthesia(when taken orally, a short-term sensation of numbness of the oral mucosa occurs), has an antispasmodic effect, blocks cholinergic receptors of the autonomic ganglia (lowers blood pressure). Blocks H3 - histamine receptors in the brain and inhibits central cholinergic structures. It has a sedative, hypnotic and antiemetic effect. It is more effective for bronchospasm caused by histamine liberators (tubocurarine, morphine, sombrevin), and to a lesser extent for allergic bronchospasm. For bronchial asthma it is inactive and is used in combination with theophylline, ephedrine and other bronchodilators.
Pharmacokinetics

After intravenous or intramuscular administration, it is widely distributed in the body, passes through the blood-brain barrier and the placenta. Binds to plasma proteins by 98-99%. Metabolized in the liver. The half-life (T1/2) is 1-4 hours. It is excreted in milk and can cause sedation in infants. Within a day, it is completely eliminated from the body, mainly in the form of benzhydrol conjugated with glucuronic acid, and only in small quantities - unchanged.

Indications for use

The drug is prescribed for treatment

• hives,
• hay fever,
• vasculitis,
• vasomotor rhinitis,
• angioedema,
• itchy dermatoses,
• acute iridocyclitis,
• allergic conjunctivitis and other allergic complications from taking various medications, including antibiotics.
• The drug is also used in the treatment of radiation sickness, chorea, sea and air sickness, and vomiting.
• Diphenhydramine solution 1% for injection can be used to reduce the severity of adverse reactions during transfusion of blood and blood-substituting fluids and other drugs.
• The drug is used as a sedative and sleeping pill alone and in combination with other hypnotics.

Directions for use and doses

The drug is used intramuscularly, intravenously. The drug is not administered subcutaneously due to its irritating effect. Intramuscularly administered at a dose of 10-50 mg (1-5 ml of 1% solution). 20-50 mg of diphenhydramine is administered intravenously in 75-100 ml of isotonic sodium chloride solution.

Maximum doses for adults when administered intramuscularly: single - 0.05 g (5 ml of 1% solution), daily - 0.15 g (15 ml of 1% solution).
special instructions

Use with caution in patients with hyperthyroidism, increased intraocular pressure, diseases of the cardiovascular system, and in old age. Should not be used by drivers while working Vehicle and people whose profession is associated with increased concentration. During the treatment period, you should avoid drinking alcoholic beverages.

Side effects

From the nervous system and sensory organs: general weakness, fatigue, sedation, decreased attention, dizziness, drowsiness, headache, impaired coordination of movements, anxiety, increased excitability (especially in children), irritability, nervousness, insomnia, euphoria, confusion, tremor, neuritis, convulsions, paresthesia ; visual impairment, diplopia, acute labyrinthitis, tinnitus. In patients with local brain damage or epilepsy, it activates (even in low doses) convulsive discharges on the EEG and can provoke an epileptic attack.

From the cardiovascular system and blood: hypotension, palpitations, tachycardia, extrasystole, agranulocytosis, thrombocytopenia, hemolytic anemia.

From the gastrointestinal tract: dry mouth, short-term numbness of the oral mucosa, anorexia, nausea, epigastric distress, vomiting, diarrhea, constipation.

From the genitourinary system: frequent and/or difficulty urinating, urinary retention, early menstruation.

From the outside respiratory system: dry nose and throat, nasal congestion, thickening of bronchial secretions, tightness in the chest and difficulty breathing.

Allergic reactions: rash, urticaria, anaphylactic shock.

Others: sweating, chills, photosensitivity.

Contraindications

• Hypersensitivity,
• lactation,
• childhood (newborn period and state of prematurity),
• angle-closure glaucoma,
• prostate hypertrophy,
• stenosing ulcer of the stomach and duodenum,
• pyloroduodenal obstruction,
• bladder neck stenosis,
• pregnancy,
• bronchial asthma.

Interaction with other drugs

Sleeping pills, sedatives, tranquilizers and alcohol enhance (mutually) the depression of the central nervous system. MAO inhibitors enhance and prolong anticholinergic effects.
Overdose

Symptoms:

dry mouth, difficulty breathing, persistent mydriasis, facial flushing, depression or agitation (more often in children) central nervous system, confusion; in children - the development of seizures and death.

Treatment:

symptomatic and supportive therapy against the background of careful monitoring of breathing and blood pressure levels.
Release form

Solution for injection 10 mg/ml in ampoules of 1 ml in packages No. 10.

Contraindications

RUE "Belmedpreparaty"