Home Audience 5 How long can you take Ciprolet? Interaction of Tsiprolet with other drugs. Vacation conditions and price

How long can you take Ciprolet? Interaction of Tsiprolet with other drugs. Vacation conditions and price

Tsiprolet – antibacterial agent from the group of fluoroquinolones, intended for the treatment of infectious and inflammatory diseases caused by microflora that are sensitive to it.

Reviews of Tsiprolet prove its speed and high therapeutic activity.

Pharmacological action of Tsiprolet

Tsiprolet causes disruption of DNA synthesis, thereby disrupting the growth and division of bacteria. According to the instructions, Tsiprolet is especially effective in the treatment of diseases caused by gram-negative bacteria (Shigella, Klebsiella, coli, salmonella, etc.). Some gram-positive bacteria (streptococci, staphylococci) are also sensitive to it. The drug can also be used to treat diseases caused by intracellular microorganisms (chlamydia, mycobacterium tuberculosis, etc.). According to reviews, Tsiprolet is highly effective in the treatment of infectious diseases caused by Pseudomonas aeruginosa.

The drug is not intended for the treatment of viral and fungal infections. It also has low activity against mycoplasmas and anaerobic bacteria.

When taken orally, Tsiprolet is well absorbed. Maximum content active substance in the blood is observed an hour and a half after administration.

Tsiprolet penetrates well into cells and therefore the drug can be used to treat diseases with intracellular localization of the pathogen.

Its elimination from the body is mainly carried out by the kidneys. The half-life is 6 – 10 hours. Therefore, it can be used twice a day.

Release form

Tsiprolet is available in two forms:

The solution for infusion is a colorless transparent liquid. In a bottle – 100.0 ml (200 mg of active substance);
Pills. They are available in dosages of 250 and 500 mg of the active substance. There are 10 tablets in one package.

Other names for Tsiprolet are: Ciprofloxacin, Tsiprinol, Siflox, etc.

Indications for Tsiprolet

Indications for the use of this drug are:

Infections of the nose, throat, ear;
Infections respiratory tract. Its use is indicated for the treatment of pneumonia caused by Enterobacter, Klebsiella, Legionella, Haemophilus influenzae and Staphylococcus;
Infections of the genitourinary organs;
Eye infections;
Soft tissue infections skin and mucous membranes;
Infections digestive system and biliary tract;
Infections of the musculoskeletal system;
Infections of the pelvic organs, including adnexitis, pelvioperitonitis, prostatitis;
Peritonitis;
Sepsis.

According to the instructions, Tsiprolet can be used for the treatment and prevention of infectious diseases in people with immunodeficiency, for example, against the background of immunosuppressive therapy.

Contraindications to the use of Tsiprolet

According to the instructions, Tsiprolet cannot be used during pregnancy, lactation, for the treatment of children and adolescents under 18 years of age, as well as with increased individual sensitivity to fluoroquinolones.

Intravenous administration of the drug is not allowed for pseudomembranous enterocolitis and glucose-6-phosphate dehydrogenase deficiency.

Tsiprolet should be prescribed with great caution for various disorders cerebral circulation, epilepsy, mental illness, severe liver or kidney failure. In elderly people, the use of Tsiprolet is undesirable.

Side effects

When using Tsiprolet, the following may occur: side effects:

From the side of the central nervous system - headache and dizziness, insomnia, feeling tired, increased intracranial pressure, ringing in the ears, diplopia, psychosis, hallucination;
From the outside digestive tract– abdominal pain, nausea, vomiting, lack of appetite, flatulence, diarrhea. The use of Tsiprolet may lead to the development of cholestatic jaundice;
From the cardiovascular system – tachycardia, hypotension;
From the outside musculoskeletal system – muscle weakness, joint and muscle pain;
Allergic reactions - itching and redness of the skin, urticaria. According to reviews, Tsiprolet causes anaphylactic shock extremely rarely;

Special instructions

If severe diarrhea occurs during treatment with Tsiprolet, the patient must be examined to exclude the development of pseudomembranous colitis, because this disease requires immediate discontinuation of the drug and the appointment of appropriate therapy.

According to reviews, Tsiprolet can contribute to the development of severe inflammation and even tendon rupture. Therefore, if pain appears in the tendons, the drug is immediately discontinued.

According to the instructions for Tsiprolet, patients should drink plenty of fluids during treatment to prevent the development of crystalluria.

When using this drug, you should not perform work that requires rapid psychomotor reaction and increased concentration.

Tsiprolet dosage regimen

For diseases of the urinary and respiratory tract, 250 mg of Tsiprolet is usually prescribed twice a day. In case of complicated course of the disease, the dose is increased and is 500–750 mg twice a day.

For the treatment of uncomplicated gonorrhea, the drug is taken once at a dose of 500 mg.

Indications for Tsiprolet are also severe enterocolitis, osteomyelitis, gynecological infections and prostatitis. In these cases, Tsiprolet is prescribed 500–750 mg every 12 hours. The duration of the course of therapy is determined by the doctor and depends on the severity of the disease.

The tablets are taken strictly before meals and should be taken with plenty of liquid.

Overdose of Tsiprolet

In case of accidental or intentional poisoning with Tsiprolet, multiple gastric lavages are performed. After the last wash, the patient is given a suspension of activated carbon. Since there is no specific antidote, symptomatic treatment.

Conditions for release from pharmacies and storage

Tsiprolet belongs to list B and is not intended for treatment without a doctor’s prescription. Therefore, it is released from pharmacies only with a prescription. It should be stored in a dark and dry place out of the reach of children. Shelf life: 5 years.

Sincerely,

The pharmaceutical medicine called ciprolet is an antimicrobial agent, and ciprolet is also an antibiotic.

Form of the drug and its composition

The drug ciprolet, its release form, comes in three types, these are:

Pills. They are round, biconvex, covered with a white shell, like the core itself. They are sealed in a blister of ten pieces. One pack may contain one or two blisters.
Solution for droppers (infusions). It is colorless and transparent. It is poured into plastic, one hundred milliliters each. In one package, one bottle, it is ready for use.
Eye drops or ointment. The drops are also colorless. The bottle has a neck with a dropper, a capacity of five milliliters. One package contains one bottle.

Tsiprolet has its analogues.

Now let's look at the Tsiprolet product and its composition:

Tablets for oral administration.

The main substance is ciprofloxacin hydrochloride. Auxiliary components are various components. The shell consists of sorbic acid, hypromellose, polysorbate 80, talc, macrogol 6000, dimethicone, titanium dioxide.

Intravenous solution.

The active ingredient is ciprofloxacin, but there are also additional components, including water for injection, and much more.

Eye drops.

The main component is ciprofloxacin hydrochloride, there are also additional components.

This drug is excreted unchanged from the body through the kidneys, that is, with urine. Its complete removal from the blood takes approximately four hours.

Indications

In order to understand how to take the drug Tsiprolet, there are instructions for its use, which must be read before taking it.

After this, the patient will find out what exactly Ciprolet is prescribed for. In addition, the ciprolet is included in the radar (register medicines Russian production).

You can’t prescribe a remedy for yourself if your friend has already taken it and it helped him.

When can you use the solution and Ciprolet tablets?

Tsiprolet has the following indications for use: inflammation in the body with infectious nature, which appear due to the sensitivity of various microorganisms. But what are they from? They treat the following infections:

In addition, the solution and tablet form of the drug are used in parallel when the infectious patient has low immunity.

Also, if a woman is diagnosed with cystitis, she is prescribed antibacterial therapy. Therefore, doctors recommend Ciprolet for cystitis in women. However, the remedy for cystitis should be taken only under the supervision of a doctor.

Many women ask the question: “Is Ciprolet an antibiotic medicine or not?” As mentioned earlier, this remedy belongs to the group of antibiotics.

Prostatitis will not go away either. Tsiprolet for prostatitis is prescribed if the cause of the disease is certain bacteria or streptococci. To destroy bacteria that cause inflammation in the pelvic organs, ciprolet is administered for prostatitis, bypassing the intestines. For example, these could be injections. When symptoms are relieved, it can be used orally. How many days the treatment will take is determined by the doctor.

You should also know that the drug ciprolet is in the form eye drops, as the instructions for use say, they are prescribed for the treatment of eye inflammation caused by bacteria, this is:

Drops also help when they are used before eye surgery.

If treatment is not suitable for you this drug due to individual intolerance to some components, do not forget that it has analogues.

Now it’s clear what this remedy helps with.

Contraindications

Tsiprolet has its contraindications, these are:

You should not drink Ciprolet during pregnancy.
Patients intolerant to one of the components of the drug.

Under strict medical supervision, you should drink Ciprolet during atherosclerosis, poor circulation and convulsions.

It should also be understood that each form of the drug has its own contraindications, so people taking the medicine on their own can greatly undermine their health.

For example, tablets and solution cannot be taken for pseudomembranous colitis and under eighteen years of age; this medicine is prescribed only to adults. This form of the drug is recommended with caution to people with various disabilities, as well as elderly patients.

Doses of the drug and its use

The medicine tsiprolet has different way application, depending on the form of release.

Tablets for oral use.

They must be drunk on an empty stomach (that is, before meals), washed down with a suitable amount of water. The dosage and how many days the therapy will take is determined by the doctor individually. Taking into account the indications, type of pathology, chronic pathologies, severity of the disease, the patient’s age and weight.

For the treatment of certain pathologies, the following proportions are recommended:

For infections of the kidneys, respiratory tract, genitourinary system different forms: mild - ciprolet 250 mg, severe - ciprolet 500 mg, taken twice.
For gonorrheal disease - 250 mg or 500 mg, at a time, before meals.
Severe infectious gynecological diseases, prostatitis. You need to take the medicine twice a day in a proportion of 500 mg.
Diarrhea - twice, 250 mg.

Therapy lasts one and a half weeks. When the symptoms completely disappear, you need to take the medicine for a couple more days.

If the signs of kidney disease are too pronounced, then the dose of the drug should be halved, as the instructions say.

If renal failure is chronic pathology, then the dose will depend on creatinine clearance.

Solution for intravenous infusion.

This drug is injected into a vein by drip; for this, it must be mixed with other solutions. The dosage is also calculated taking into account all the patient’s indications.

The duration of administration is calculated so that 200 mg is infused in half an hour.

For different severity, their proportions are prescribed, for example: moderate - 400 mg, twice a day, severe - 800 mg, twice. Treatment requires fourteen days, in some cases more.

Acute form of gonorrhea, treated with 100 mg solution, once.

To prevent infection from occurring after surgery, use 200 mg half an hour before the start of the intervention.

Eye drops.

Drops are used by instilling into the sore eye. The dose also depends on the severity of the disease: mild and moderate form - two drops four times a day, severe form - two drops hourly. As soon as the patient's condition has improved, the dose and frequency are reduced.

When a patient is diagnosed with a corneal ulcer, the treatment regimen is unique. It is developed by the doctor who treats the patient.

Possible side effects

The product Tsiprolet has side effects, which differ depending on the form of the drug.

Tablets for oral use and solution for droppers.

Since Tsiprolet is a medicine, when infectious pathologies various systems body, it can cause the following phenomena:

Nervous system: headache, dizziness, weakness, tremors in the limbs, lack of sleep, anxiety, nightmares, increased sweating, high blood pressure, depressive state, fainting and much more.
Digestive system: nausea, vomiting, diarrhea, bloating and others.
Sense organs: impaired taste, incorrect perception of smells, tinnitus, hearing loss.
Blood: anemia, thrombocytosis, leukocytosis.
Heart and blood vessels: decreased levels blood pressure, palpitations, tachycardia, hot flashes.
Bones and muscles: arthritis, tendon ruptures and more.
Genitourinary system: urinary retention, hematuria, bleeding from the urethra and others.
Laboratory indicators: changes in normal values.
Allergies: shortness of breath, itching, swelling of the face and throat, vasculitis, photophobia, Lyell's syndrome, blisters on the skin.
General malaise.
Eye drops.

When using drops, the following complications in the organs of vision may occur: slightly noticeable pain, conjunctivitis, burning, itching, swelling of the eyelids, loss of vision and much more.

In addition, other side effects may occur, such as nausea, allergies.

There are also other side effects, such as a bad taste after using the medicine.

If the patient is diagnosed special pathologies nervous system, such as seizures, epilepsy, pathologies blood vessels, then Ciprolet should be used according to indications.

Now let's look at whether it is possible to drink alcohol while being treated with this remedy? The answer is simple, it is impossible to combine ciprolet and alcohol, because the effect of alcoholic drinks is almost the same as the effect on the body this tool. But if it so happens that you mixed ciprolet and alcohol, then after taking it, expect such side effects, such as nausea, vomiting, tremors in the limbs, anxiety, depression, nightmares and much more. Therefore, try not to combine Ciprolet with alcohol.

If, while using this drug, the patient experiences prolonged diarrhea, you need to be tested for pseudomembranous colitis. If the diagnosis is confirmed, then the use of the solution or tablets should be stopped immediately.

Also, you should not use these forms of the drug in the future if the first symptoms of tendon rupture appear.

The use of tablets and solution must be combined with large fluid intake. However, this is only possible if the patient has normal urination.

During the entire course of therapy, you should not sunbathe and stay in the sun for a long time.

You should also give up contact lenses.

If you use two different eye drops, then take a short break between procedures, at least five minutes, or even more.

Please note that this remedy affects the reaction, so you should not drive a car or use other machinery during therapy.

Interaction with other medications

You need to know that the medicine Ciprolet is prescribed with caution if another group of antibiotics is used, because it is also classified as an antibiotic. In addition, it is necessary to warn the doctor, saying that I am taking this or that drug.

The compatibility of Ciprolet with other medications varies, so you need to know which one is not allowed, for example:

Didanosine. After it, ciprofloxacin is poorly absorbed.
Theophylline concentrates the drug too much in the blood, causing poisoning.
Medications containing zinc, magnesium, iron, aluminum ions, on the contrary, interfere with the absorption of the drug, so you need to take a break between taking them. But how long after you can drink them is after at least four hours. Thus, their compatibility will not be affected negative impact on the body.
Cyclosporine will enhance negative impact on the kidneys.
Other anti-microbial medications will enhance their effects together with Ciprolet.
Nonsteroidal medications that reduce inflammation will increase the risk of seizures.

It is also worth using other drugs carefully, especially without knowing their compatibility.

In the case of individual infections, there is a possible combination of the following combinations of drugs:

Streptococcal. Mezlocillin, Azlocillin and another drug called an antibiotic.
Staphylococcal. Vancomycin.
Anaerobic. Metronidazole, clindamycin.

Their compatibility with Ciprolet is justified.

Ciprolet analogues

There are medicines that can replace ciprolet, which is an analogue of the medicine; they can also be in three forms.

Pills.

The analogues are: ciprofloxacin, tsiprinol, tsiprobay.

Solutions for droppers, they also have analogues.

Ificipro, quintor.

Eye drops.

Tsipromed, rocip and others. They are similar to ciprolet.

When choosing drug substitutes, check with your doctor whether it is an analogue.

Storage conditions and terms when use is possible

The main thing is that this product should be kept away from children. It should be stored in a dry and dark place, with a temperature no higher than twenty-five degrees. Eye drops and solution for intravenous administration cannot be frozen.

Tsiprolet tablets and solution are good for three years, and drops for two years; they cannot be stored longer. Once a bottle of eye drops has been opened, it should be used within one month.

Tsiprolet is available only with a doctor's prescription. The manufacturer of this drug is India.

Tsiprolet - a new description of the drug, you can see the pharmacological action, side effects, prices in pharmacies for Tsiprolet. Reviews about Tsiprolet -

Antimicrobial agent wide range actions of the fluoroquinolone group.
Drug: CIPROLET®
Active substance of the drug: ciprofloxacin
ATX coding: J01MA02
KFG: Antibacterial drug of the fluoroquinolone group
Registration number: P No. 008395
Registration date: 02/26/06
Owner reg. cred.: DR. REDDY`S LABORATORIES LTD. (India)

Solution for infusion in the form of a clear, colorless or light yellow liquid. Solution for infusion 1 ml 1 vial. ciprofloxacin 2 mg 200 mg
Excipients: sodium chloride, lactic acid, disodium edetate, citric acid monohydrate, sodium hydroxide, hydrochloric acid, water for injection.
100 ml - bottles (1) complete with a loop for fastening - cardboard packs.

DESCRIPTION OF THE ACTIVE SUBSTANCE.
All information provided is provided for information only about the drug; you should consult your doctor about the possibility of use.

Pharmacological action of Tsiprolet

Broad-spectrum antimicrobial agent of the fluoroquinolone group. Has a bactericidal effect. Suppresses DNA gyrase and inhibits bacterial DNA synthesis.
Highly active against most gram-negative bacteria: Pseudomonas aeruginosa, Haemophilus influenzae, Escherichia coli, Shigella spp., Salmonella spp., Neisseria meningitidis, Neisseria gonorrhoeae.
Active against Staphylococcus spp. (including strains that produce and do not produce penicillinase, methicillin-resistant strains), some strains of Enterococcus spp., Campylobacter spp., Legionella spp., Mycoplasma spp., Chlamydia spp., Mycobacterium spp.
Ciprofloxacin is active against bacteria that produce beta-lactamases.
Resistant to ciprofloxacin Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides. The effect against Treponema pallidum has not been sufficiently studied.

Pharmacokinetics of the drug.

Rapidly absorbed from the gastrointestinal tract. Bioavailability after oral administration is 70%. Food intake has little effect on the absorption of ciprofloxacin. Plasma protein binding is 20-40%. Distributed in tissues and body fluids. Penetrates cerebrospinal fluid: concentrations of ciprofloxacin with non-inflamed meninges reach 10%, with inflamed meninges - up to 37%. High concentrations are achieved in bile. Excreted in urine and bile.

Indications for use:

Infectious and inflammatory diseases caused by microorganisms sensitive to ciprofloxacin, incl. respiratory tract diseases, abdominal cavity and pelvic organs, bones, joints, skin; septicemia; severe infections of the ENT organs. Treatment of postoperative infections. Prevention and treatment of infections in patients with reduced immunity.
For local use: acute and subacute conjunctivitis, blepharoconjunctivitis, blepharitis, bacterial corneal ulcers, keratitis, keratoconjunctivitis, chronic dacryocystitis, meibomitis. Infectious eye lesions after injury or foreign bodies. Preoperative prophylaxis in ophthalmic surgery.

Dosage and method of administration of the drug.

Individual. Orally - 250-750 mg 2 times a day. The duration of treatment is from 7-10 days to 4 weeks.
For intravenous administration, a single dose is 200-400 mg, the frequency of administration is 2 times a day; Duration of treatment is 1-2 weeks, or more if necessary. Can be given intravenously as a bolus, but is more preferable drip administration within 30 min.
When applied topically, instill 1-2 drops into the lower conjunctival sac of the affected eye every 1-4 hours. After the condition improves, the intervals between instillations can be increased.
Maximum daily dose: for adults when taken orally - 1.5 g.

Side effects of Tsiprolet:

From the digestive system: nausea, vomiting, diarrhea, abdominal pain, increased activity of liver transaminases, alkaline phosphatase, LDH, bilirubin, pseudomembranous colitis.
From the central nervous system: headache, dizziness, feeling of fatigue, sleep disorders, nightmares, hallucinations, fainting, visual disturbances.
From the urinary system: crystalluria, glomerulonephritis, dysuria, polyuria, albuminuria, hematuria, transient increase in serum creatinine.
From the hematopoietic system: eosinophilia, leukopenia, neutropenia, change in platelet count.
From the cardiovascular system: tachycardia, disorders heart rate, arterial hypotension.
Allergic reactions: itchy skin, urticaria, Quincke's edema, Stevens-Johnson syndrome, arthralgia.
Adverse reactions associated with chemotherapy: candidiasis.
Local reactions: pain, phlebitis (with intravenous administration). When using eye drops, in some cases, mild soreness and hyperemia of the conjunctiva are possible.
Other: vasculitis.

Contraindications to the drug:

Pregnancy, lactation ( breast-feeding), children's and adolescence up to 15 years old, increased sensitivity to ciprofloxacin and other quinolone drugs.

Use during pregnancy and lactation.

Ciprofloxacin penetrates the placental barrier and is excreted in breast milk.
Experimental studies have shown that it causes arthropathy.

Special instructions for use of Tsiprolet.

In patients with impaired renal function, dosage regimen adjustment is required. Use with caution in elderly patients, with atherosclerosis of cerebral vessels, cerebrovascular accidents, epilepsy, convulsive syndrome unknown etiology.
During treatment, patients should receive sufficient fluids.
In case of persistent diarrhea, ciprofloxacin should be discontinued.
With simultaneous intravenous administration of ciprofloxacin and barbiturates, monitoring of heart rate, blood pressure, and ECG is necessary. During treatment, it is necessary to control the concentration of urea, creatinine, and liver transaminases in the blood.
During treatment, a decrease in reactivity is possible (especially when used simultaneously with alcohol).
Ciprofloxacin should not be administered subconjunctivally or directly into the anterior chamber of the eye.

Interaction of Tsiprolet with other drugs.

With simultaneous use of ciprofloxacin with didanosine, the absorption of ciprofloxacin is reduced due to the formation of ciprofloxacin complexes with aluminum and magnesium buffers contained in didanosine.
When used simultaneously with warfarin, the risk of bleeding increases.
Concomitant use of ciprofloxacin and theophylline may lead to increased plasma theophylline concentrations due to competitive inhibition at cytochrome P450 binding sites, resulting in an increase in the elimination half-life of theophylline and an increased risk of theophylline-related toxicity.
Simultaneous use of antacids, as well as drugs containing aluminum, zinc, iron or magnesium ions, can cause a decrease in the absorption of ciprofloxacin, so the interval between the administration of these drugs should be at least 4 hours.

.
The drug inhibits topoisomerases and DNA gyrases of pathogens, causing their death. The mechanism of action is bactericidal.

The dose of antibiotic and duration of treatment are selected individually. In this case, it is important to take into account the localization of the infectious-inflammatory process, its severity, the sensitivity of the pathogen, the age of the patient, and the presence of background conditions that aggravate the course of the disease.

If the disease is caused by Pseudomonas aeruginosa, staphylococci or acinetobacter, high doses Tsiproleta ® may also be required combination therapy(two antibacterial drugs).

Pharmacological group

Fluoroquinolone antibiotics.

Tsiprolet ® tablets 250 and 500 mg and infusion solution: composition

Table 250 and 500 each contain 0.25 and 0.5 grams of ciprofloxacin, respectively. The composition also contains additional, inactive components. Tablets may contain MCC, starch, colloidal silicon dioxide, talc, magnesium stearate, propylene glycol, etc.

The infusion solution additionally contains lactic and hydrochloric acid, water for injection, etc.

Release forms of Tsiprolet ®

The drug is available in the form:

Tablets of 250 and 500 mg, ten tablets per package;
Flak. one hundred mg each containing 200 mg of ciprofloxacin (parenteral form);
Eye drops 3 mg per milliliter (5 ml per bottle).

Photo of packaging of ciprolet in tablets of 500 mg

There is also Tsiprolet A ® .

What is the difference between Tsiprolet A ® and regular Tsiprolet ®?

Tsiprolet A ® is combination drug, containing an antibiotic and an imidazole derivative capable of exhibiting antiprotozoal activity - imidazole.

Eye drops

Prescribed for adults and children over a year old. The recommended dose is 1-2 drops every four hours. For severe infections, it can be used every two hours. After the severity of clinical symptoms decreases, the intervals between instillations are increased to 4 hours. The standard course of treatment is from 5 to 14 days.

For the treatment of tank. corneal ulcers should be prescribed 1 drop four times an hour for 6 hours. Next - 1 drop, twice an hour. On the second day, 1 drop. every hour. From the third to the 14th day, the standard is a drop every four hours. Exceeding the two-week course is permissible only as prescribed by a doctor if there is no epithelization of the ulcer.

Other drugs of ciprofloxacin:

Recipe for the antibiotic Tsiprolet ® in Latin

Rp: Ciprolet 0.25
D.t.d: N 10 in tab.
S: 1 table each. every twelve hours.

Tsiprolet ® tablets and solution for infusion - what are they for?

The spectrum of action of the drug includes:

Active against penicillin-, cephalosporin-, aminoglycoside- and tetracycline-resistant strains.

Moderately effective against Mycobacterium tuberculosis, Streptococcus pneumoniae, Streptococcus pyogenes, Mycoplasma.

Bacteroides, fungi, treponemes, methicillin-resistant staphylococci, and ureaplasma are resistant to ciprofloxacin.

Indications and contraindications for the use of Tsiprolet ®

The product is highly effective in treating:

severe, complicated;
can be used for paratonsillar and retropharyngeal abscesses;
severe infections lower breath pathways (complicated, cystic fibrosis, infected bronchiectasis);
osteomyelitis;
intra-abdominal infections;
inflammation of the pelvic organs;
shigellosis;
inf. skin and fatty acids;
sepsis;
bacteremia;
and pelvioperitonitis;
Neutopenia.

Drops are prescribed for the treatment of conjunctivitis; corneal ulcers tank. nature; ; keratitis; , meibomyites;

Contraindications to the use of Tsiprolet ® are:

It is prescribed with caution for mental illness, atherosclerosis, elderly patients or with liver or kidney diseases (accompanied by a decrease in creatinine clearance).

Drops are not prescribed to children under one year of age (if there is an alternative, it is not recommended to use them under 12 years of age); pregnant women; nursing; with a viral nature of the disease; due to individual intolerance.

Applications of Tsiprolet ® during pregnancy and breastfeeding

Due to the high toxicity of the antibiotic and its ability to be excreted in milk, it is prohibited to prescribe it during pregnancy and during breastfeeding.

Tsiprolet ® drops are also contraindicated in this category of patients.

Dosage of Tsiprolet ®

When administered parenterally

Tsiprolet ® in the form of a solution for infusion is used intravenously. The duration of administration should be about 60 minutes.

In case of organ damage respiratory system administer 200 milligrams twice a day.

For patients with uncomplicated gonorrhea, a single dose of 0.1 gram once is sufficient.

For the treatment of infections. urinary tract(non-elephant) is prescribed 0.1 g every 12 hours.

For pyelonephritis or complicated UTIs, it is necessary to prescribe 0.2 g twice a day.

The duration of the course depends on the severity of the disease. When normalizing clinical picture and maintaining positive dynamics for 48 hours, the issue of switching to the table is being considered. form of drug use.

Dose adjustments are not made for liver diseases. Changing the dosage of the antibiotic or increasing the time intervals between doses is required for patients with renal failure and elderly patients.

When taken orally

Exacerbation chronic sinusitis or otitis medium degree severity is also treated with 500 mg twice a day or 750 mg (severe, complicated course).

The duration of treatment is from 1 to 2 weeks. If necessary, in the first days of the disease Tsiprolet ® can be used parenterally (injections), followed by switching to the table. form of the drug.

Severe otitis externa takes an average of 28 days (0.75 grams every 12 hours).

Treatment of uncomplicated cystitis (mild and moderate course of the disease) lasts three days. The recommended dose is 0.25 to 0.5 grams.

If the disease is accompanied by frequent relapses or complications develop, treatment is extended to seven days. The daily dose is 1 gram, divided into two doses.

For complicated pyelonephritis, Tsiprolet ® is taken from 10 days to three weeks (in case of abscess development). Dose: 500 to 750 mg twice daily.

Treatment course for prostatitis acute illness averages from 2 to 4 weeks and about 6 weeks with chronic course. The daily dose is from 1 to 1.5 grams in two doses.

Gonococcal infection (uncomplicated urethritis and) is treated with a single dose of 500 milligrams of the drug once.

Therapy for pelvic inflammation takes 14 days (1-1.5 grams per day in two doses). If you suspect mixed flora combination therapy is prescribed.

To eliminate travelers' diarrhea, a single dose of 500 milligrams is also prescribed.

For diarrhea caused by dysenteric Shigella type 1, 0.5 grams of the drug are prescribed for five days. For vibrio cholerae, the same doses are recommended - three days.

For the treatment of typhoid fever, use 1 gram per day (divided into two doses) for seven days.

For intra-abdominal infections caused by gram-negative flora, it is necessary to use 1-1.5 g/day for five to 14 days.

Infect. skin and PFA must be treated for seven to 14 days, with a dose of 0.5 grams or 750 mg of medication every 12 hours.

Treatment purulent inflammation bone tissue and joints can take up to three months.

In persons with immunodeficiency conditions, Tsiprolet ® (1-1.5 g per day, in two doses) is combined with other antimicrobials. Treatment must be continued throughout the period of neutropenia.

Prescription for children

Fluoroquinolone drugs are not prescribed before the age of eighteen. Exceptions may include Levofloxacin ® and Ciprofloxacin ® . They can be used in as a last resort, for health reasons, if other antibiotics are ineffective and there is no safe alternative, from 15 years of age.

For cystic fibrosis or other severe, complicated infections. The dosage of Tsiprolet for children is up to 20 mg/kg twice a day. The maximum single dose is 0.75 grams.

The duration of therapy depends on the location and severity of the disease. Cystic fibrosis – from 10 to 14 days. Severe pyelonephritis (complicated by abscesses) – from 10 to 21 days.

Side effects of Tsiprolet ®

Fluoroquinolone preparations are highly toxic and have large number side effects. The most characteristic features of this group of antibiotics are increased photosensitivity and pronounced toxic effect on the tendons.

Side effects may also include allergic reactions. varying degrees severity, heart rhythm disturbances, kidney and liver damage, phlebitis at the injection site. Subject to change in general and biochemical analyzes blood, headache, convulsions, .

When using drops, itching, lacrimation, pain and stinging in the eyes, and swelling of the eyelid are possible.

Features of the drug use

Despite the fact that the antibiotic can be taken regardless of food intake, the instructions for use of tablets of 250 and 500 mg recommend taking them on an empty stomach with a glass of boiled water, then achieving maximum speed suction.

Table should not be chewed or dissolved in liquid. It is forbidden to drink antibiotics with juices, soda, compotes, etc. Also, during treatment, you must stop taking yoghurt, milk, juices, soda, and sweets.

Compatibility of Tsiprolet ® and alcohol

It is important to remember that Tsiprolet ® and alcohol are categorically incompatible. This combination can lead to serious, irreparable consequences for health.

When Tsiprolet ® is combined with alcohol, toxic damage to the nervous system is possible, manifested by tremors of the limbs, severe headache, vomiting, loss of orientation in space, anxiety, and hallucinations. Ethanol also enhances the negative effect of fluoroquinolone on the kidneys and liver, which can lead to severe nephritis, kidney failure, and toxic hepatitis.

In addition, alcohol reduces the effectiveness of treatment, that is, such a combination will provide side effects for health, but the effectiveness of taking an antibiotic will be zero.

Indications for use:
Ciprolet - solution for infusion and tablets are used for infections caused by bacteria sensitive to ciprofloxacin (including mixed infections):
Respiratory infections: exacerbation chronic bronchitis, pneumonia, bronchopneumonia, lung abscess, empyema, infectious pleurisy, infected bronchiectasis, pulmonary infections in patients with fibrocystic changes in the lungs;
· infections of the genitourinary system: prostatitis, chronic and acute pyelonephritis, cystitis, epididymitis;
ENT infections: otitis media, sinusitis, mastoiditis;
· gynecological infections: adnexitis, salpingitis, oophoritis, endometritis, pelvic abscess, pelvioperitonitis, infected ulcer;
· gonorrhea, including rectal, urethral and pharyngeal localization of gonococcal lesions, including cases caused by resistant gonococci;
· infections of the abdominal organs: cholecystitis, peritonitis, intra-abdominal abscesses, cholangitis, gallbladder empyema;
· infections of joints and bones: purulent arthritis, chronic and acute osteomyelitis;
infectious diseases gastrointestinal tract: typhoid fever, bacterial diarrhea;
· general severe infectious diseases: bacteremia, septicemia and infections in patients with suppressed immunity;
soft tissue and skin infections: infected wound, cellulite, burn, abscess.

Tsiprolet - eye drops
· Therapy of infectious diseases of the eyes and ocular appendages that are caused by microorganisms sensitive to ciprofloxacin (bacterial keratoconjunctivitis and keratitis, acute and subacute conjunctivitis, blepharitis, blepharoconjunctivitis, bacterial corneal ulcer with hypopyon, bacterial corneal ulcer without hypopyon, chronic meibomyitis and dacryocystitis);
· therapy in the aftermath of surgical purulent-inflammatory infectious complications as a result of ophthalmological operations;
· infectious lesions in the first hours after eye injuries or due to foreign bodies;
· in ophthalmic surgery - for preoperative prophylaxis.

Pharmacological action:
Tsiprolet is an antibacterial agent. The active ingredient of the product is ciprofloxacin (an antimicrobial substance of the fluoroquinolone group). Ciprofloxacin affects bacterial topoisomerase (DNA gyrase), which helps suppress the reproduction of microbial DNA. It has a bactericidal effect, expressed in the impact on both microorganisms at rest and during their active reproduction. Active against gram-positive and gram-negative bacteria: E. coli, Salmonella, Shigella, Klebsiella, Citrobacter, Serratia, Enterobacter, Edwardsiella, Hafnia, Proteus (indole-negative and indole-positive strains), Yersinia, Providencia, Vibrio, Aeromonas, Pasteurella, Haemophilus, Plesiomonas , Campylobacter, Legionella, Neisseria, Moraxella, Pseudomonas, Branhamella, Brucella, Staphylococcus, Acinetobacter, Streptococcus agalacticae, Corynebacterium, Listeria, Chlamydia.
The spectrum of action of ciprofloxacin also includes microorganisms that produce beta-lactamases. Flavobacterium, Streptococcus pyogenes, Gardnerella, Alcaligenes, Mycoplasma hominis, Streptococcus pneumoniae, Mycobacterium tuberculosis, Steptococcus viridans, Mycobacterium fortuitum have variable susceptibility to ciprofloxacin.
Ciprofloxacin has no effect on Bacteroides, fungi and Treponema pallidum.
The following bacteria are usually resistant: Ureaplasma urealyticum, Steptococcus faecium, Pseudomonas maltophilia, Nocardia asteroides, Pseudomonas cepacia, Bacteroides fragilis, Clostridium difficile.
Those strains of staphylococci that are resistant to methicillin are also insensitive to ciprofloxacin. With some exceptions, anaerobic microorganisms (Peptosreptococcus, Peptococcus) are also moderately sensitive to the active substance of ciprolet.
Ciprofloxacin does not interfere with the quantity and quality of normal vaginal and intestinal microflora. Immunity to ciprofloxacin develops gradually and slowly; there is no resistance of plasmid origin. Ciprofloxacin is active against bacteria resistant, for example, to aminoglycosides, beta-lactam antibiotics or tetracyclines.
After taking the product, ciprofloxacin is well and quickly absorbed. Bioavailability is 50–85%. Volume of distribution - 2–3 l/kg. Maximum plasma concentrations are reached after 60–90 minutes. Ciprofloxacin penetrates well into tissues and organs, as well as bones. Slightly binds to plasma proteins (20–40%). After 120 min. after oral administration ciprofloxacin is detected in body fluids and tissues in concentrations that are many times greater than its plasma concentration.
The level of ciprofloxacin concentration necessary to inhibit bacteria is maintained for 0.5 days. The active substance of Tsiprolet accumulates in organs and tissues, where its content exceeds the plasma concentration several times.
Ciprofloxacin is eliminated from the body mostly unchanged: mainly by the kidneys - within 50–70%. After oral administration, the half-life from blood plasma is approximately 3–5 hours, after intravenous administration it is 4 hours. The predominant part of ciprofloxacin is also excreted by the intestines (with feces and bile - up to 30%), so in case of significant violation renal functions there is a slowdown in elimination from the body.

Tsiprolet - eye drops
To study systemic absorption, a solution of ciprofloxacin was injected into the conjunctival sac for 7 days in the following regimen: after 2 hours for the first 2 days, and then after 4 hours for the next 5 days. The maximum plasma concentration of ciprofloxacin is determined to be less than 5 ng/ml. Average plasma concentration is ≤2.5 ng/ml. These data indicate non-corresponding systemic absorption of ciprofloxacin.

Tsiprolet method of administration and dosage:
Tsiprolet - tablets
Designed for adults and children over 15 years old. The tablets are taken orally, regardless of food. For better absorption, it is recommended to take it before meals with plenty of water. The dosage is set individually, depending on the type of pathogen, the course of infectious process and the patient's renal function. Tablets should be taken at regular intervals (usually every 12 hours).

For lower respiratory tract infections, 250-500 mg is prescribed 2 times a day. In case acute pneumonia, associated with Streptococcus pneumoniae, is prescribed 1.5 g/day (divided into 2 doses - every 12 hours).
For infections of the genitourinary system (uncomplicated) - 250 mg 2 times a day.
For complicated genitourinary tract infections or prostatitis - 500 mg 2 times a day.
For infections of the musculoskeletal system and ENT infections - 500–750 mg 2 times a day.
At gynecological diseases- 500 mg 2 times a day.
For acute intestinal infection - 500 mg 2 times a day.
For gastroenteritis - 250 mg 2 times a day.
For peritonitis, bacteremia and sepsis, ciprofloxacin is used first in the form of an intravenous infusion, then treatment is continued at 500–750 mg 2 times a day in the form of Tsiprolet tablets.

The duration of treatment depends on the results of bacteriological studies and the severity of the infection (approximately the course of treatment ranges from 5 to 7 days). It is recommended to continue taking Tsiprolet for another 3 days after all symptoms of the infectious process have stopped.
In patients with severe renal failure with creatinine clearance below 20 ml/min, the dosage of Tsiprolet is reduced by 2 times.

It is used intravenously in a dosage that depends on the clinical situation. A single dose should be administered over 30–60 minutes.
For respiratory infections - 200 mg 2 times a day.
For uncomplicated acute gonorrhea - 100 mg once a day.
For infections of the urinary system (uncomplicated) - 100 mg 2 times a day.
For complicated or severe infections of the urinary system - 200 mg 2/day.
For other infections - 200 mg 2 times a day.
The duration of therapy depends on the clinical course, severity of the disease and the results of bacteriological examination.
In case inflammatory processes urinary tract, kidney and abdominal infections, treatment is continued for up to 7 days. Can be used for osteomyelitis for up to 2 months. When oppressed immune reactions body treatment with Tsiprolet is carried out throughout the entire period of neutropenia. The duration of therapy for cystitis and acute uncomplicated gonorrhea is 1 day. For other infections, the duration of therapy is from 7 to 14 days. It is recommended to continue administration of the product for another 3 days after the signs of the disease disappear or body temperature normalizes.
Release of Tsiprolet in two dosage forms provides the opportunity to begin therapy for severe infections intravenously, and then continue to take it orally.

Tsiprolet - eye drops
IN case of lung and moderately severe infectious process, Tsiprolet is prescribed to children over 12 years of age and adults, 1-2 drops in the affected eye every 4 hours. Tsiprolet can be used every hour for severe infections (1-2 drops per eye). After the condition improves, the frequency of instillation is reduced to 1–2 drops every 4 hours. Therapy is continued until the symptoms of the disease disappear. The course of treatment ranges from 5 to 14 days, depending on the severity of the infectious process.

Ciprolet contraindications:
General contraindications to all forms of release of Tsiprolet
· high susceptibility to ciprofloxacin, as well as other components of the drug;
· high susceptibility to other fluoroquinolones.

Tsiprolet - solution for infusion and tablets
· children under 15 years of age;
· period of pregnancy and lactation.

Tsiprolet - ophthalmic drops
· children under 12 years of age.

Ciprolet side effects:
Tsiprolet - solution for infusion and tablets
The drug is well tolerated by patients. Therapy with Tsiprolet can cause the following side effects (usually reversible):
· From the gastrointestinal tract and liver: lack of appetite, vomiting, nausea, diarrhea, flatulence, cholestatic jaundice, abdominal pain, hepatitis;
· from the cardiovascular system: hot flashes, tachycardia, heart rhythm disturbances, migraine, arterial hypotension (very uncommon);
· from the psyche, analyzers and nervous system: feeling of fatigue, insomnia, headache, dizziness, loss of consciousness, high excitability, tremor; very in rare cases- unsteadiness during gait, sweating, feeling of fear, seizures, nightmares, decreased attention, hallucinations, depression, visual disturbances; (chromatopsia, diplopia), temporary decrease in hearing acuity, especially for high-pitched sounds, tinnitus, thrombosis of cerebral arteries. If such effects occur, you must stop taking Tsiprolet and consult a doctor;
on the part of the immune system: itchy skin, drug-induced fever, skin rash, photosensitivity is possible; not often - bronchospasm, angioedema and joint pain, very rarely - myalgia, interstitial nephritis, anaphylactic shock, Lyell's syndrome (toxic epidermal necrolysis), Stevens-Johnson syndrome, hepatitis;
· from the hematopoietic system: leukopenia, eosinophilia, granulocytopenia, thrombocytopenia; very rarely - thrombocytosis, leukocytosis, hemolytic anemia;
· from the musculoskeletal system: there are isolated reports of ruptures of the Achilles tendon and shoulder tendons while taking Tsiprolet, which required surgical intervention. If any symptoms develop, Tsiprolet should be discontinued;
· from the urinary system: crystalluria, hematuria, glomerulonephritis, dysuria, urinary retention, polyuria, urethral bleeding, albuminuria, interstitial nephritis;
· from laboratory parameters: increased levels of alkaline phosphatase and transaminases, especially in patients with impaired liver function (usually temporary); temporary increase in the concentration of creatinine, urea and bilirubin in the blood serum; hyperglycemia is also possible.

Tsiprolet - eye drops
Possible itchy eyes allergic reactions, mild hyperemia and soreness of the conjunctiva, burning, nausea. Photophobia, swelling of the eyelids, sensation foreign body in the eyes, lacrimation, bad taste in the mouth immediately after instillation, decreased visual acuity, keratopathy, keratitis, the appearance of infiltration of the cornea or spots on it.

Pregnancy:
The safety of taking Tsiprolet (tablets and solution for infusion) during pregnancy and breastfeeding has not been established, therefore it is not recommended to prescribe the product to women during these periods.

Overdose:
There is no data on an overdose of Tsiprolet eye drops.
In case of an overdose of Tsiprolet, symptomatic treatment is carried out. Slightly effective (up to 10% elimination active substance) peritoneal and hemodialysis. There is no specific antidote.

Use with others medicines:
Antacids, which include magnesium and aluminum hydroxide, as well as products containing iron or zinc ions, can reduce the absorption of ciprofloxacin in the stomach, so it is necessary to maintain an interval of at least 4 hours between taking these drugs.
The simultaneous administration of products that contain theophylline with Tsiprolet is accompanied by an increase in the plasma concentration of theophylline, therefore it is recommended to adjust the dose so that symptoms of theophylline overdose do not develop.

With the simultaneous use of warfarin and Tsiprolet, the effect of warfarin may be potentiated.
The risk of developing seizures increases with the simultaneous use of non-steroidal anti-inflammatory drugs (except acetylsalicylic acid). When used simultaneously with Tsiprolet, oral hypoglycemic products, non-steroidal anti-inflammatory drugs (except acetylsalicylic acid) and xanthines increase their concentration in the blood plasma and lengthen the half-life.
Probenecid reduces the elimination of ciprofloxacin from the body.
With the simultaneous use of cyclosporine and Tsiprolet, in some isolated cases, an increase in the severity of the nephrotoxic effect of cyclosporine is observed, which is accompanied by an increase in the level of plasma creatinine. When combining these products, it is recommended to monitor creatinine levels quite often (2 times a week).
Tsiprolet can be combined with antimicrobial drugs of other groups: aminoglycosides, cephalosporins, penicillins and products that are used in the treatment of infections caused by anaerobic bacteria(eg metronidazole).

Tsiprolet can be prescribed in combination with vancomycin and isoxazoylpenicillins for infections of staphylococcal etiology. Tsiprolet can be prescribed in combination with ceftazidime and azlocillin for infections associated with Pseudomonas; with azlocillin and mezlocillin, as well as other effective beta-lactam antibiotics for infections caused by streptococci.
There is no data on the interaction of Tsiprolet eye drops with other medications.

Release form:
Tsiprolet - tablets - 250 each; 500 mg ciprofloxacin. There are 10 tablets in a pack.
Tsiprolet - solution for infusion - 100 ml bottles (200 mg of active substance). The pack contains 1 bottle.
Tsiprolet - eye drops - 5 ml bottles (3 mg in 1 ml). The pack contains 1 bottle.

Storage conditions:
Tsiprolet - tablets are stored in a place protected from moisture and light at a temperature of 15–25°C.
Tsiprolet, a solution for infusion, is stored in a place protected from light at a temperature of 2–25°C. Freezing of the solution is not allowed.
Tsiprolet - eye drops - in a place protected from light, at a temperature of 2–25°C. After opening, store the bottle for no more than 4 weeks if the temperature condition is 2–25°C. Freezing of drops is not allowed.

Synonyms:
Cipro, Ciprova, Ciprolac, Quintor, Arflox, Ciprobay, Ciplox, Ciprobid, Ciprinol, Ciproran, Ciproxin, Cipromid, Cipropane, Ciprosan, Medociprin, Tsifobak, Ciprocinal, Afenoxime, Citeral, Cifran, Ciprofloxacin.

Tsiprolet composition:
Tsiprolet - tablets 250 mg
Active substance: ciprofloxacin hydrochloride 250 mg.
Inactive substances: talc, microcrystalline cellulose, corn starch, magnesium stearate, colloidal silicon dioxide, hydroxymethylcellulose 2910, sodium starch glycolate, propylene glycol, titanium dioxide.

Tsiprolet - tablets 500 mg
Active substance: ciprofloxacin hydrochloride 500 mg.
Inactive substances: talc, microcrystalline cellulose, corn starch, magnesium stearate, colloidal silicon dioxide, hydroxymethylcellulose, sodium starch glycolate, propylene glycol, titanium dioxide.

Tsiprolet - solution for infusion
Active substance: ciprofloxacin lactate (200 mg in 100 ml, 2 mg in 1 ml).
Inactive substances: lactic acid, disodium edetate, sodium hydroxide, sodium chloride, hydrochloric acid, citric acid monohydrate, water for injection.

Tsiprolet - ophthalmic drops
Active substance: ciprofloxacin hydrochloride 3 mg in 1 ml.
Inactive substances: mannitol, disodium EDTA, sodium acetate, acetic acid, benzalkonium chloride, water for injection.

Additionally:
Tsiprolet - tablets and solution for infusion
When taking the product, avoid sun exposure ( high probability photosensitivity). Tsiprolet is used with caution in patients with disorders of the central nervous system (cerebrovascular accident, epilepsy, convulsions, severe forms atherosclerosis) and elderly patients. It is necessary to refrain from types of work that require increased attention and speed of psychomotor reactions (for example, drivers of vehicles).
Alkaline environment urine may lead to a slightly reduced uroantiseptic activity of Tsiprolet, acidic environment urine also prevents the development of crystalluria. When using Tsiprolet, a sufficient water load on the body is necessary, since there is a possibility of developing crystaluria.
For patients on peritoneal dialysis in case of peritonitis, the product is prescribed orally at 500 mg 4 times a day.
If creatinine clearance is below 20 ml/min, or serum creatinine content is more than 3 mg/100 ml (renal failure), it is necessary to reduce the daily dose of Tsiprolet by 2 times, administration is allowed daily dose once a day.

Tsiprolet - eye drops
Allowed only local application drops Do not inject Tsiprolet eye drops into the anterior chamber of the eye or subconjunctivally. In case of prolonged eye irritation or increased local reactions instillation of drops is stopped. An opened bottle is used for 1 month. While using drops, you should refrain from work related to driving vehicles and any other mechanisms that require high speed psychomotor reactions and high concentration attention. It is not recommended to use contact lenses while instilling Tsiprolet.

Attention!
Before using the medication "Tsiprolet" You should consult your doctor.
The instructions are provided for informational purposes only. Tsiprolet».