Flemoxin solutab contraindications. Flemoxin is a well-known antibiotic in an innovative form

Wide use many bacterial pathologies in modern world requires the use of a new generation of antibiotics with minimal side effects and good performance efficiency. The drug that most closely matches these parameters is Flexoxin Solutab, a generic version of the well-known antibiotic amoxicillin.

It belongs to a number of penicillin antibacterial agents, and this makes it possible to use it for almost all categories of patients. The antibiotic Flemoxin Solutab for children can be prescribed for infectious pathologies respiratory, digestive and genitourinary system. In many modern recommendations Ammoxicillin preparations are in the first line of treatment.

Characteristics of the drug

The active ingredient of the drug Flemoxin Solutab is amoxicillin. It belongs to the synthetic representatives of beta-latam antibiotics. Like other penicillins, Flemoxin Solutab has a pronounced bactericidal effect.

It is realized by violating the integrity of the cell membrane of pathogenic organisms. This leads to their lysis and death. At the same time, a negative effect is also possible here. With the mass death of a large number of certain gram-negative microorganisms (meningococci), a toxin contained inside the bacteria is released into the human blood.

This can lead to the development of bacterial sepsis. Therefore, the drug should only be used under the supervision of a qualified specialist.

Flemoxin Solutab only acts on bacterial pathogens. Use of the drug for viral infections completely unjustified, and often only worsens the general condition of the patient. The following types of bacteria are sensitive to this antibiotic:

• most strains of streptococci;
• clostridia;
• Neisseria (meningococci and gonococci);
• Helicobacter pylori infection;
• some staphylococci (which do not synthesize penicillinase);
• enterococci;
• bacteroides;
• Vibrio cholerae;
• listeria;
• proteas.

Such a wide range of sensitivity allows the use of Flemoxin Solutab for many bacterial pathologies in children and adults.

Pharmacological properties of Flemoxin Solutab

The drug is available in the form of dispersible tablets, which changes the absorption parameters of the active substance. At orally This form of antibiotic increases the proportion of amoxicillin that enters the systemic circulation. On the one hand, this increases the concentration of the drug, and on the other hand, it reduces the local effect on the intestinal bacterial flora, which reduces the frequency of dyspeptic disorders. Food intake has no effect on absorption rates.

The drug penetrates well into many tissues of the body - mucous membranes, bones, bile. Flemoxin passes through the blood-brain barrier unhindered during inflammation of the meningeal membranes.

The drug is only partially metabolized in the body. Ammoxicillin is excreted from the bloodstream primarily by the kidneys. active form, which allows it to be used for inflammation of the genitourinary tract.

The half-life is 90-120 minutes, making it necessary to frequent repetition taking the drug. Some part of Flemoxin is excreted through bile into the digestive system. If renal function is impaired, the half-life increases significantly, which must be taken into account when prescribing the drug.

Rules for prescribing Flemoxin

Only a doctor can correctly prescribe Flemoxin Solutab. First he must make sure bacterial etiology infectious process. For this purpose, he carefully collects an anamnesis of the patient’s disease and life. Some symptoms indicate bacterial origin diseases. Additionally, there are large-scale studies that show which pathogens most often cause certain pathologies.

Next step - laboratory research. Increased number of leukocytes, neutrophils, shift leukocyte formula to the left and an increase in ESR (erythrocyte sedimentation rate) often indicate a bacterial etiology of the disease.

Most exact method diagnostics - taking a swab from the nasopharynx, a sample of urine, sputum or blood for bacteriological examination. It allows not only to accurately determine the exact strain of the pathogen, but also to study which antibacterial drugs are most effective against it. A significant drawback of the method is the duration of the procedure (several days), while the decision to prescribe treatment must be made immediately.

Therefore, national and European recommendations, in which, taking into account empirical experience and conducted research, it is described which drugs and antibiotics should be used for a specific pathology.

How to take an antibiotic correctly

The antibacterial drug should be used only after being prescribed by a qualified specialist. Self-medication is strictly not recommended, since patients themselves are not able to objectively assess the symptoms of the pathology and choose the drug that is most suitable for them.

Their most common mistake is the use of antibacterial agents for viral pathologies, when their effectiveness is minimal. This also leads to an increase in antibiotic resistance of bacterial flora in the population - very acute problem modern clinical medicine.

You should take Flemoxin Solutab at a specific time of day. This allows you to maintain the therapeutic concentration of the drug for as long as possible. If you miss taking an antibiotic, do not panic. In this case, you should take the missed dose as quickly as possible, and then continue treatment as usual.

It is recommended to take a tablet of the drug only plain water. Using juices, strong coffee or alcohol for this purpose can change the pharmacological properties of the antibiotic.

You cannot stop the antibiotic yourself at the first signs of improvement. general condition.

Very often this leads to a rapid recurrence of the disease, since only a full course of treatment completely destroys the infectious process.

The effectiveness of the drug is usually assessed after 2-3 days of therapy. Pay attention to the dynamics of the clinical picture, as well as laboratory parameters. If necessary, visualization methods are also used. If there is no positive dynamics, then the doctor should consider changing the antibiotic or adding a new drug.

Indications for use of Flemoxin Solutab

Flemoxin Solutab antibiotic is prescribed only for a confirmed bacterial infection, or when it is necessary to effectively prevent it during various manipulations or operations.

When using the drug, it is necessary to take into account the sensitivity of possible pathogens. First of all, Flemoxin Solutab is used for the following pathologies:

• bronchitis;
• tracheitis;
• community-acquired pneumonia without complications;
• pharyngitis;
• laryngitis;
• sinusitis;
• acute otitis media;
• gastritis or duodenitis caused by Helicobacter pylori infection;
• urethritis;
• cystitis;
• exacerbations of chronic pyelonephritis;
• inflammation of the uterus or its appendages.

For most of the above pathologies, Flemoxin Solutab is used as the drug of choice. This is due to its low toxicity, as well as good performance indicators.

Contraindications to the use of Flemoxin

An absolute contraindication to the use of Flemoxin is the patient's history of allergic reactions to beta-lactam antibiotics.

Moreover we're talking about not only about penicillins, but also about cephalosporins, carbapenems and monobactams.

This is due to the similarity of their chemical structure. Because of this, the phenomenon of “cross hypersensitivity” is observed. Such patients should be prescribed macrolides, fluoroquinolones or tetracyclines instead of beta-lactam drugs.

When prescribing amoxicillin to patients with infectious mononucleosis develops varying severity of skin lesions. Therefore, with the least suspicion of this pathology, Flemoxin cannot be used.

Since the drug is metabolized and excreted from the body primarily by the kidneys, it should be prescribed with great caution in case of functional failure of this organ. In such cases, the doctor needs to adjust the dose of the antibiotic, taking into account the glomerular filtration rate, to avoid overdose.

Amoxicillin is one of a number of antibiotics that are approved for use during pregnancy and lactation. However, at the same time, supervision by a doctor is necessary.

Possible side effects

When using Flemoxin, the most commonly observed side effects are: digestive system. The development of dyspeptic symptoms (nausea, vomiting, feeling of heaviness in the abdomen) is described. More dangerous complication- pseudomembranous colitis caused by clostridial infection. This pathology may have different clinical symptoms.

In some patients it manifests itself only as short-term diarrhea, while in others it is severe pain along the intestines, septic shock and defeat of cardio-vascular system. When a diagnosis of pseudomembranous colitis is made, Flemoxin should be immediately discontinued.

In addition, allergic reactions may develop varying degrees severity - from the appearance of a red rash with severe itching to Quincke's edema and anaphylactic shock. Toxic drug-induced dermatitis - Stevens-Johnson syndrome - is also possible.

Sometimes a transient increase in liver enzymes in the blood is observed, which normalize after completion of the course of therapy. Cases of the development of interstitial nephritis have been described.

Also, some patients experienced suppression of hematopoiesis, which is manifested in the laboratory by a decrease in the amount shaped elements(erythrocytes, leukocytes and platelets).

Symptoms include the addition of a secondary bacterial, viral or fungal infection, cases of bleeding in the skin or mucous membranes.

At long-term use Flemoxin can be added resistant to this antibiotic infections.

All manifestations side effects must be assessed by the attending physician. Only he can decide whether it is necessary to continue drug therapy in these situations.

Interaction with other drugs

The combined use of Flemoxin with other bactericidal drugs gives a synergistic effect. At the same time, using it with many bacteriostatic antibiotics is unjustified, since due to the different mechanism of action, the effectiveness of treatment decreases.

The use of the drug with allopurinol (prescribed for basic treatment of gout during remission) may lead to an increase in the appearance of skin rashes. Therefore, for such patients, it is recommended to use other antibiotics, or switch from allopurinol to adenuric.

Drugs that affect the glomerular filtration rate (probenecid, sulfinpyrazone, phenylbutazone) can increase the half-life of the drug from the patient's body. In such cases, it is necessary to prescribe reduced doses of the drug and monitor its concentration in the blood.

Flemoxin also reduces the effectiveness of oral hormonal contraceptives. There is also an increase in the frequency of uterine bleeding in patients.

For a child

This antibacterial drug is characterized by low toxicity, so it is allowed to be taken from the first year of a child’s life. The drug is available in tablets, however, for small patients you can grind it into powder and add a small (up to 100 ml) amount of water. The result is a suspension with a pleasant fruity taste.

The dose of the antibacterial drug depends on the child’s age and body weight. The required amount of antibiotic is obtained at the rate of 30 mg per 1 kg. For some severe conditions the dose can be increased to 60 mg of the drug per 1 kg of body weight. This number is then divided into 3 doses. Typically, tablets containing 125 mg, 250 mg or 500 mg of amoxicillin are used for children.

The duration of therapy is at least 3 days.

For some diseases of the genitourinary system, it can take up to 3-4 weeks.

For an adult

According to the instructions, the antibiotic Flemoxin is usually prescribed to adult patients in the form of tablets of 500 or 750 mg. This dose allows you to create the necessary therapeutic concentration in the blood. You need to take the antibacterial drug 2 or 3 times a day.

For some pathologies, for example, with otitis media, the dose can be increased to 1000 mg at a time.

Possible drug overdose

Very few cases of overdose with Flemoxin have been described. Most of them were observed in patients with chronic renal impairment or during therapy with other drugs (especially probenecid). Sometimes patients with memory problems mistakenly took a repeat dose of the antibiotic.

In such cases, a clinical picture of the lesion was observed digestive tract with dyspeptic symptoms (nausea, vomiting, abdominal pain).

In case of overdose, you must immediately stop taking Flemoxin, rinse your stomach with regular digested water and take absorbents ( Activated carbon or its analogues).

Conclusion

Flemoxin Solutab - modern drug out of line penicillin antibiotics. It has a number of advantages over traditional amoxicillin due to the dispersive form of the tablet, which increases its bioavailability and reduces the incidence of side effects.

The low toxicity of the drug allows it to be used for children in the first year of life. The antibiotic is effective against a large number of bacterial pathogens. Usually it is taken for at least 3 days.

Video

The video talks about how to quickly cure a cold, flu or acute respiratory viral infection. Opinion of an experienced doctor.

Is your baby sick and your doctor has prescribed him an antibiotic? Nowadays, few people do not know that antibiotics are effective, since they are one of them in the group of penicillins, the semi-synthetic drug Flemoxin Solutab 250 appeared. The drug is produced in white-light yellow tablets. The tablets have oval shape. They bear the company logo and the digital designation -231 on one side. On the other side there is a line, which conditionally divides the tablet into two parts.

If your baby gets an infection respiratory tract, then the doctor can prescribe him Flemoxin Solutab. The fact is that it contains amoxicillin. This substance helps get rid of diseases. He is appointed:

• At various infections eyes, nose, throat.
• For infectious diseases of the kidneys, urine - genital tract, gastrointestinal, skin.
• For infectious diseases in the organs of the excretory system.
• For diseases affecting the digestive organs.
• For various purulent wounds.

Its effect applies only to bacteria. Viruses such as influenza and acute respiratory viral infections cannot be treated with it. For children aged 5 to 10 years, Flemoxin Solutab 250 is prescribed. One tablet has 250 mg.

About the benefits of the drug

Its advantages are obvious:

• The use of the drug is practically without side effects.
• It has unique bioavailability.
• Combination with medications and dietary supplements (dietary supplements).
• Amazing release form.

The drug does not cause side effects, although the instructions indicate a number of ailments when using this medicine. The point is that they were carried out clinical trials, and out of thirty babies, only one of them developed small rashes on the face. But they did not create any inconvenience for the child, because they quickly disappeared. Flemoxin Solutab 250 is a very mild drug, so your doctor may prescribe it:

1. During the period when a woman is expecting a baby.
2. While breastfeeding.

The bioavailability of the drug is that the effect active component the drug has 93% availability. That is, it is not digested during the process of absorption by the body, but acts only for medicinal purposes.

Flemoxin Solutab has a special tablet form. This form of Solutab was patented by a Dutch company, which produces this drug.

In tablet form, this medicine can be used both before and after meals. You can give it to your child during meals. Pharmacists have ensured that this medicine does not affect food intake at all. That is, the body completely absorbs this medicine.

It can be taken with meals, after meals and before meals. The developers developed the taste of this drug, so if the child cannot swallow the tablet, he will simply chew it. He will be pleased to try a new candy. Another feature is that the tablet can be used in the form of a delicious fruit syrup. You can make it yourself from a tablet.

About efficiency

Clinical trials were conducted in a group with babies who had acute otitis media. One experimental group consisted of forty-two children, the other control group consisted of forty-one children. For the experimental group of children, Flemoxin Solutab 250 was prescribed, for the control group - regular ampinicillin.

The experiment showed that acute otitis media was cured most quickly in children aged one and a half to five years. Already on the third day, the ear pain went away. But in the group where Flemoxin was taken, even older children recovered quickly.

About methods of use

The dosage of the drug Flemoxin Solutab is prescribed by the attending physician. Only he can appreciate individual characteristics baby and the course of his illness. Children aged ten years take Flemoxin Solutab twice a day. Quantity -500 mg. Your doctor may prescribe the medication three times a day. This is already 375 mg.

For small children, three and up to ten years old, the doctor prescribes medication twice a day, 375 mg, or in the morning at lunch and in the evening, 250 mg. For sick children from one to three years of age, the doctor prescribes 250 mg of medication in the morning and evening, or 125 mg three times a day.

If the baby’s illness is severe, the doctor prescribes three doses of medication.

In addition, a complex disease or recurrent form of infection will require an increase in the daily amount of medication. The doctor may prescribe a medication dosage ratio of 60 mg per kg of baby’s weight. Then the baby will have to receive Flemoxin Solutab three times a day.

There are cases when the baby’s kidneys are not working well, then the doctor can reduce the amount of medicine consumed to half. In case of a child’s illness occurring in mild form, just five to seven days of using the medicine Flemoxin Solutab 250 is enough, and it will go away. For streptococcus, treatment continues for up to ten days.

It is better to dissolve the medicine in the form of a tablet for a baby in water. For a baby, one tablet is dissolved in 20 mm of water. The result is syrup. You can make a fruit suspension that kids really like. In this case, one tablet must be dissolved in one hundred milligrams of water. On average, it turns out that for one kg of a child’s weight there are 30 mg of medication.

Thus, you can treat your baby with this drug in two or three doses. To support health, doctors recommend taking it together with a dietary supplement (biologically active additives), which contain vitamins or with agents that help normalize intestinal microflora.

Flemoxin is wide range actions. Belongs to the group of penicillins. Used to treat infectious and inflammatory diseases. This drug has a detrimental effect on many pathogenic microorganisms.

The drug is based on a semi-synthetic antibiotic – amoxicillin. This antibiotic belongs to the group of penicillins. In its own way chemical structure and degree of activity is similar to ampicillin.

It should be remembered that when using Flemoxin simultaneously with other bactericidal drugs, the therapeutic effect is enhanced.To eliminate the disease, it is important to complete the full course of treatment with the drug. It is prohibited to use Flemoxin on your own, as adverse reactions may occur.

There are specific guidelines for using the drug. If individual intolerance to amoxicillin is observed, then the drug for the treatment of various infectious diseases It is prohibited to accept. In this case, the doctor will choose another medicine.

Restrictions on the use of the drug:

• According to the instructions, the drug should not be taken by people with kidney failure and ulcerative colitis.
• Flemoxin is prescribed with caution to people with gastrointestinal pathologies, lymphocytic leukemia or infectious mononucleosis. Substances included in the drug may cause exacerbation of the above diseases.
• An antibiotic is prescribed only if the risk to the fetus from the drug is less than the expected benefit to the mother. It is not recommended to use Flemoxin during lactation.

The antibacterial drug is well tolerated in the treatment of various infectious diseases. However, if the dosage specified in the instructions is not followed, adverse reactions may occur:

• While taking the drug, you may experience headache, nausea, diarrhea. After antibiotic treatment, women may experience fungal infection. IN in rare cases the patient may complain of vomiting and abdominal pain.
• It is also possible that allergic reactions may occur in the form of skin rashes, urticaria, dermatitis, etc.
• Taking Flemoxin can lead to pseudomembranous colitis. This is a fairly serious adverse reaction caused by clostridia. Colitis causes severe diarrhea, which causes the body to become severely dehydrated.

If some adverse reactions You should notify your doctor about this and stop taking the drug. If necessary, carried out symptomatic therapy. Taking this into account, the doctor will prescribe another medicine.

Interaction with other drugs

If your doctor has prescribed Flemoxin to treat an infectious disease, you must warn him about what medications you are already taking. When some drugs interact, various reactions may occur.

Simultaneous use of Flemoxin and contraceptive drugs leads to a decrease in the desired therapeutic effect of the latter. In this case, there is a risk of appearance.Ascorbic acid increases the absorption of the active substance Flemoxin.

Antibiotic absorption decreases with joint use with laxatives, as well as drugs that reduce stomach acidity.The combination of Flemoxin and Alopurinol can lead to skin rashes.The level of antibiotic in blood plasma increases with simultaneous administration Phenylbutazone, Probenecid, Oxyphenabutazone, non-steroidal anti-inflammatory drugs.

Analogues of the drug

There are drugs Flemoxin, which are similar in composition and properties.

Popular analogues of Flemoxin include:

• Amoxil. wide spectrum of action. It is available in the form of a solution and tablets, so it can be administered intravenously and taken orally. The dosage for children is 250 mg, for adults from 250 to 500 mg.
• Amosin. Antimicrobial semisynthetic drug. Used for acute infectious diseases of the upper and lower respiratory tract, diseases of the digestive tract, urogenital infections, meningitis, borreliosis. The antibiotic is contraindicated in allergic diathesis, bronchial asthma, hay fever, severe digestive disorders. The drug is not prescribed to children under 3 years of age.
• Gonoform. An antibacterial drug that prevents the growth and division of pathogenic bacteria. Available in the form of granules, and. Helps get rid of infectious diseases.
• Ospamox. Antibiotic penicillin group. Can be used during asymptomatic bacteriuria, cystitis, pyelonephritis. Also used to treat gynecological infections.
• Danemox. Bactericidal drug. Has the same properties as Flemoxin Solutab. Available in tablets with the active ingredient of 250 mg and 500 mg. Dispensed with a doctor's prescription.
• Amoxisar. The antibiotic can be used to treat infectious diseases in both children and adults. The medicine is administered intravenously, intramuscularly or orally. The duration of treatment depends on the severity.
• Hiconcil. The drug has a wide spectrum of bactericidal action. Used to treat diseases caused by various pathogenic bacteria. Contraindicated for use during pregnancy, renal failure, mononucleosis. Convenient to use for children in the form.
• Other analogs of antibiotics Flemoxin: Ecobol, Gramox-D, Iramox, Baktos, V-Mox, etc.

Of the large number of analogues listed above, Flemoxin Solutab is the only one domestic analogue is Gramox-D. They don’t always buy it for treatment imported medicine, which is several times more expensive than the domestic drug.

Antibacterial drugs should only be prescribed qualified specialist. You should be aware that many Flemoxin analogues have side effects, although healing effect the same.

Name: Flemoxin Solutab

Name: Flemoxin Solutab

Indications for use:
Infections caused by bacteria sensitive to amoxicillin (diseases of the genitourinary system, respiratory system, gastrointestinal tract, infections of soft tissues and skin).

Pharmachologic effect:
Broad-spectrum antibacterial agent. The active ingredient of Flemoxin Solutab is amoxicillin trihydrate (semi-synthetic penicillin, beta-lactam antibacterial agent). Has a bactericidal effect. Effective against gram-negative and gram-positive bacteria, such as: S. pneumoniae, Streptococcus pyogenes, Clostridium tetani, Neisseria gonorrhoeae, C. welchii, N. meningitidis, Moraxella catarralis, Staphylococcus aureus, Bacillus anthracis, Staphylococcus spp, Listeria monocytogenes, Haemophilus influenzae, Helicobacter pylori. Less effective against pathogens intestinal infections: Escherichia coli, Shigella sonnei, Enterococcus faecalis, Salmonella typhi, Proteus mirabilis, Vibrio cholere. Inactive against microorganisms that produce beta-lactamase, as well as against indole-positive Proteus, Pseudomonas, Enterobacter.

Peculiarity dosage form(Solyutab) after oral administration ensures rapid absorption in the gastrointestinal tract and complete (over 93%) absorption. Taking with food is not accompanied by changes in the absorption of the active ingredient of the product. Maximum concentration amoxicillin in the blood plasma is detected after 60-120 minutes. after reception. When taking Flemoxin Solutab, a higher maximum concentration of amoxicillin in the blood plasma is observed than when taking the insoluble dosage form of this antibiotic. Acid-resistant active substance.

After internal administration of amoxicillin at a dose of 375 mg, Cmax in blood plasma is observed after 120 minutes (6 μg/l). The maximum concentration of amoxicillin in the product Flemoxin Solutab increases 2 times if dose taken– 2 times higher than 375 mg. Amoxicillin is bound to plasma proteins in an amount of 20% of the administered dose. Accumulation of antibiotics when prescribed therapeutic doses The product occurs in bone tissue, mucous membranes, intraocular fluid, and sputum. In bile, there is an increase in the concentration of amoxicillin compared to its level in the blood by 2-4 times. Approximately 25-30% of amoxicillin (compared to the content in the blood) is determined in the umbilical vessels and within the fetal fluid. Despite the insufficient passage of amoxicillin through the blood-brain barrier, 20% of amoxicillin from its concentration in the blood plasma is determined in the cerebrospinal fluid during meningitis.

In the body it is partially metabolized to inactive metabolites. Excreted by the kidneys: 20% by glomerular filtration and 80% by tubular excretion. After 8 hours of taking the product, 90% of the active substance is excreted in the urine (and unchanged - 60-70%).

IN childhood(up to 6 months, in premature babies) the half-life of amoxicillin is 3-4 hours. When normal functioning kidneys, the half-life of the active substance is 1-1.5 hours. In case of violations renal functions(creatinine clearance - 15 ml/min or less) the half-life increases and can reach up to 8.5 hours with anuria. If liver function is impaired, the half-life does not change.

Flemoxin Solutab method of administration and dosage:
Flemoxin Solutab has a pleasant tangerine-lemon taste. The tablets are swallowed without chewing and taken before or after meals. You can divide the tablet into several parts and chew it with water. It is also possible to dissolve the tablet in water (20 ml to obtain a syrup, 100 ml to obtain a suspension).

Flemoxin Solutab is prescribed for infections of bacterial origin, mild and medium degree severity at a dose of 0.5-2 g per day, the daily dose is divided into 2 doses (for adults). In pediatrics, it is prescribed to children from 1 year of age: from 1 year to 3 years – 0.125 g 3 times a day or 0.25 g 2 times a day; from 3 to 6 years - 0.25 g 3 times a day or 1.375 g 2 times a day. The course of treatment is 5-7 days. At streptococcal infections It is recommended to take the product for 10 days. Approximately, children are prescribed the product at the rate of 30-60 mg/kg body weight per day, divided into 2-3 doses. The dosage is prescribed by the doctor individually, depending on age, general condition, severity of the disease and sensitivity of microorganisms to amoxicillin.

In case of severe infections, or for recurrent, chronic diseases, use a dose of 0.75-1 g 3 times a day. In pediatrics – 60 mg/kg body weight (divided into 3 doses.)

For eradication of Helicobacter pylori infection: 2 g/s (divided into 2 doses).
For uncomplicated acute gonorrheal infection - 3 g per 1 dose in combination with probenecid (1 g).

If renal function is impaired with creatinine clearance less than 10 ml/min, the dosage is reduced by 15-50%.
Reception of Flemoxin Solutab should continue after the disappearance of signs of the disease for another 2 days.

Flemoxin Solutab contraindications:
Allergic reaction to antibacterial products of the penicillin and cephalosporin series, as well as to additional substances Flemoxin Solutab.

Flemoxin Solutab side effects:
Rare side effects: itching in the area anal opening, diarrhea, interstitial nephritis; thrombocytopenia, hemolytic anemia, agranulocytosis, allergic skin reactions in the form of small papular rash.
Very rare: hemorrhagic and pseudomembranous colitis, Steven Johnson syndrome, erythema multiforme, Quincke's edema, anaphylactic shock.

Pregnancy:
Flemoxin Solutab is not contraindicated for pregnant and nursing mothers.

Overdose:
An overdose of Flemoxin Solutab may have the following symptoms: vomiting, nausea, diarrhea. Vomiting and diarrhea can cause dehydration of the body and disruption of water and electrolyte balance. In case of overdose, enterosorbents, saline laxatives, and hydration measures are prescribed.

Use with other medications:
Inhibition of the tubular excretion of amoxicillin is observed when combined with phenylbutazone, probenecid, oxyphenbutazone, and, to a lesser extent, acetylsalicylic acid and sulfinpyrazone. This may lead to increased plasma concentrations of amoxicillin and an increase in its half-life.

A decrease in the effectiveness of hormonal contraceptives when combined with amoxicillin was found.
Unlike ampicillin, the combination of amoxicillin with allopurinol does not increase the incidence of skin reactions.
Bacteriostatic agents neutralize the bactericidal effect of amoxicillin antibacterial agents(macrolides, tetracyclines, chloramphenicol).

Release form:
Tablets 125; 250; 500; 1000 mg. Tablets are white or white-yellow, oblong in shape. Engravings: for tablets 125 mg – “231”; 250 mg – “232”; 500 mg – “234”; 1000 mg – “236”. On one side of the tablet is the logo of the manufacturer, on the other - the risk. Contains 20 tablets in a contour coating.

Storage conditions:
Do not use after the date indicated on the pack. Store at room temperature.

Flemoxin Solutab composition:
Active substance: amoxicillin trihydrate.
Additional components: microcrystalline cellulose, dispersed cellulose, vanillin, crospovidone, saccharin, tangerine flavor, lemon flavor, magnesium stearate.

Additionally:
It has been shown that when prescribing products to patients with lymphocytic leukemia or infectious mononucleosis penicillin series appearance often develops skin rash –
exanthema (60-100%), which is not due to hypersensitivity to the product. A similar effect in the life history is not a contraindication to the prescription of penicillins, incl. and amoxicillin.

Allergic reactions when taking ampicillin occur more often than when using penicillins, but less often than when taking ampicillin.
There is cross-resistance between antibacterial drugs cephalosporin and penicillin series.
There is a risk of developing superinfection, as in the case of prescribing penicillins.
At the first sign of pseudomembranous colitis (severe diarrhea), appropriate treatment is necessary.

Attention!
Before using the medication "Flemoxin Solutab" You should consult your doctor.
The instructions are provided for informational purposes only. Flemoxin Solutab».

Before purchasing the antibiotic Flemoxin Solutab, you must carefully read the instructions for use, methods of use and dosage, as well as other useful information on the drug Flemoxin Solutab. On the website "Encyclopedia of Diseases" you will find all necessary information: instructions for correct use, recommended dosage, contraindications, as well as reviews from patients who have already used this drug.

Flemoxin Solutab is a broad-spectrum penicillin antibiotic that is destroyed by penicillinase.

Flemoxin Solutab - Release form, composition, packaging

Dispersible tablets are white to light yellow in color, oval, with the company logo and the digital designation “231” on one side and a score dividing the tablet in half on the other side.

amoxicillin trihydrate 145.7 mg,

which corresponds to the content of amoxicillin 125 mg

Excipients: dispersible cellulose - 4.3 mg, microcrystalline cellulose - 6.3 mg, crospovidone - 6.3 mg, vanillin - 0.13 mg, tangerine flavor - 1.1 mg, lemon flavor - 1.4 mg, saccharin - 1.6 mg, magnesium stearate - 0.76 mg.

Dispersible tablets are white to light yellow in color, oval, with the company logo and the digital designation “232” on one side and a score dividing the tablet in half on the other side.

amoxicillin trihydrate 291.4 mg,

which corresponds to the content of amoxicillin 250 mg

Excipients: dispersible cellulose - 8.7 mg, microcrystalline cellulose - 12.6 mg, crospovidone - 12.6 mg, vanillin - 0.26 mg, tangerine flavor - 2.3 mg, lemon flavor - 2.8 mg, saccharin - 3.3 mg, magnesium stearate - 1.5 mg.

5 pieces. - blisters (4) - cardboard packs.

Dispersible tablets are white to light yellow in color, oval, with the company logo and the digital designation “234” on one side and a score dividing the tablet in half on the other side.

amoxicillin trihydrate 582.8 mg,

which corresponds to the content of amoxicillin 500 mg

Excipients: dispersible cellulose - 17.4 mg, microcrystalline cellulose - 25.2 mg, crospovidone - 25.2 mg, vanillin - 0.5 mg, tangerine flavor - 4.5 mg, lemon flavor - 5.6 mg, saccharin - 6.6 mg, magnesium stearate - 3 mg.

5 pieces. - blisters (4) - cardboard packs.

Dispersible tablets are white to light yellow in color, oval, with the company logo and the digital designation “236” on one side and a score dividing the tablet in half on the other side.

amoxicillin trihydrate 1.1655 g,

which corresponds to the content of amoxicillin 1 g

Excipients: dispersible cellulose - 34.8 mg, microcrystalline cellulose - 50.5 mg, crospovidone - 50.4 mg, vanillin - 1 mg, tangerine flavor - 9.1 mg, lemon flavor - 11.1 mg, saccharin - 13.1 mg, magnesium stearate - 6 mg.

5 pieces. - blisters (4) - cardboard packs.

Flemoxin Solutab - Pharmacological action

The pharmacological action of the drug is antibacterial and bactericidal.

Pharmacodynamics

Active against such gram-positive and gram-negative microorganisms as Streptococcus pyogenes, Streptococcus pneumonia, Clostridium tetani, C.welchii, Neisseria gonorrhoeae, Neisseria meningitidis, Staphylococcus aureus (not producing beta-lactamase), Bacillus anthracis, Listeria monocytogenes, Helicobacter pylori. Less active against Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Salmonella typhi, Shigella sonnei, Vibrio cholerae. Not active against microorganisms producing beta-lactamases, Pseudomonas spp., indole-positive Proteus spp., Serratia spp., Enterobacter spp.

Pharmacokinetics

Suction

After oral administration, it is absorbed quickly and almost completely (about 93%), acid-stable. After oral administration at a dose of 500 mg, the Cmax of the active substance in plasma is 5 mcg/ml and is observed in the blood plasma after 2 hours. When the dose of the drug is increased or decreased by 2 times, Cmax in the blood plasma also changes by 2 times. Food intake has virtually no effect on the absorption of the drug.

Distribution

Plasma protein binding is about 20%. Flemoxin Solutab penetrates well into mucous membranes, bone tissue, intraocular fluid and sputum in therapeutically effective concentrations. The concentration of amoxicillin in bile exceeds its concentration in blood plasma by 2–4 times. In amniotic fluid and umbilical vessels, the concentration of amoxicillin is 25–30% of its level in the blood plasma of a pregnant woman.

Penetrates poorly through the BBB, but in case of inflammation meninges the concentration in the cerebrospinal fluid is about 20% of the concentration in the blood plasma.

Metabolism

Partially metabolized, most of its metabolites are inactive against microorganisms.

Removal

Eliminated mainly by the kidneys, about 80% by tubular excretion, 20% by glomerular filtration. In the absence of renal dysfunction, T1/2 is 1–1.5 hours. In premature infants, newborns and children under 6 months - 3–4 hours.

Pharmacokinetics in special clinical situations

T1/2 of amoxicillin does not change with impaired liver function.

If renal function is impaired (Cl creatinine ≤15 ml/min), T1/2 of amoxicillin may increase and reaches 8.5 hours in anuria.

Flemoxin Solutab – Indications for use

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug, namely:

- infections of the skin and soft tissues;

- respiratory infections;

- infections of the genitourinary system;

- infections of the gastrointestinal tract.

Flemoxin Solutab - Dosage and method of administration

Take orally, before, during or after meals. The tablet can be swallowed whole, divided into pieces or chewed with a glass of water or diluted in water to form a syrup (20 ml) or suspension (100 ml).

Adults and children over 10 years of age (for mild and moderate severity) - 500–750 mg 2 times a day or 375–500 mg 3 times a day.

Children from 3 to 10 years old - 375 mg 2 times a day or 250 mg 3 times a day; from 1 year to 3 years - 250 mg 2 times a day or 125 mg 3 times a day. Daily dose for children (including children under 1 year) - 30–60 mg/kg/day, divided into 2–3 doses.

When treating severe infections, as well as infections with hard-to-reach foci (for example, acute otitis media) it is preferable to take the drug three times.

For chronic diseases, relapses, severe infections: adults - 0.75–1 g 3 times a day, children - up to 60 mg/kg/day in 3 divided doses.

For acute uncomplicated gonorrhea - 3 g, once, in combination with 1 g of probenecid.

For mild to moderate infections, treatment is carried out for 5–7 days, for infections caused by Streptococcus pyogenes - at least 10 days.

When treating chronic diseases and severe infections, the dose of the drug should be determined clinical picture diseases. The drug is continued for 48 hours after the symptoms of the disease disappear.

For patients with creatinine Cl below 10 ml/min, the dose is reduced by 15–50%.

Flemoxin Solutab - Contraindications and restrictions

Definite contraindication:

- hypersensitivity to the components of the drug;

- hypersensitivity to other beta-lactam antibiotics, incl. to other penicillins, cephalosporins, carbapenems.

The drug should be used with caution in cases of polyvalent hypersensitivity to xenobiotics, a history of gastrointestinal diseases (especially with colitis associated with the use of antibiotics), renal failure, during pregnancy and lactation, allergic reactions(including in medical history).

Use during pregnancy and breastfeeding: It is possible to prescribe the drug during pregnancy and lactation if the expected benefit of therapy for the mother outweighs the risk of side effects in the fetus and infant.

Amoxicillin is released in small amounts from breast milk, which can lead to the development of sensitization phenomena in an infant.

Use for renal impairment: For patients with impaired renal function with CC≤10 ml/min, the dose of the drug is reduced by 15-50%.

Use in children: Used in children according to indications according to the dosage regimen.

Flemoxin Solutab - Side effects and overdose

From the digestive system: rarely - change in taste, nausea, vomiting, dysbacteriosis, stomatitis,; in some cases - a moderate increase in the activity of liver transaminases, cholestatic jaundice, hepatic, acute cytolytic hepatitis, pseudomembranous and hemorrhagic colitis.

From the urinary system: development of interstitial nephritis, crystalluria.

From the hematopoietic system: , .

From the outside nervous system : agitation, anxiety, insomnia, ataxia, behavioral changes, peripheral neuropathy, epileptic seizures.

Allergic reactions: skin reactions, mainly in the form of a specific maculopapular rash, skin hyperemia, erythematous rashes, rhinitis, conjunctivitis, (), fever, arthralgia, eosinophilia, exfoliative dermatitis, reactions similar to serum sickness, toxic epidermal necrolysis, acute generalized exanthematous pustulosis; in some cases - angioedema.

Other: difficulty breathing, vaginal candidomycosis, superinfection (especially in patients with chronic diseases or reduced body resistance).

Overdose

Symptoms: gastrointestinal dysfunction - nausea, vomiting, diarrhea; Vomiting and diarrhea may result in water and electrolyte imbalance.

Treatment: gastric lavage, activated charcoal, saline laxatives are prescribed; measures are taken to maintain water and electrolyte balance, hemodialysis.

Flemoxin Solutab - Special instructions

The drug should be prescribed to patients with infectious mononucleosis and lymphocytic leukemia with caution, since there is a high probability of non-allergic origin.

Gonoform;

The composition and principle of action of all these drugs is very similar. Therefore, choose the most suitable analogue Flemoxin Solutaba can only be taken with the help of a professional.

Flemoxin Solutab – Reviews

Vitaly

I decided to try ordering Solutab online and I was not mistaken. I looked at all the photographs of the drug, I understood everything about the dosage. In addition, I even bought some children’s medicine—vitamins, a candy substitute. Autumn quickly buy a lot of cheap drugs, replacing expensive ones.

Dima

A friend was prescribed solutab, something with her lungs. And as luck would have it, the illness happened on her anniversary, for which she had been preparing for six months. The instructions say nothing about compatibility with alcohol. Does anyone have experience?

Olga

The first acquaintance with this drug, oddly enough, did not leave any special impressions! Apparently, the reason was my excessive “expectation of a miracle” or the fact that I was used to children’s antibiotics in suspensions, BUT at some point I decided to try Flemoxin Solutab again and did not regret it! The drug does its job quite confidently and quickly (on average, three days and the effect is obvious), without causing visible harm to the gastrointestinal tract (unlike suspensions). It has gone through fire and water (purulent tonsillitis, laryngitis, obstructive bronchitis, etc.) In addition to the action, the convenience is that, unlike suspensions, a pack of the drug is enough for more than one treatment cycle!

Catherine

I had never used an online pharmacy before, I went to see how much Flemoxin Salutab cost, it turned out I could buy it cheaper. If you take the course, it heals well, although it’s not cheap, I don’t want to use a substitute.

Inna

The child developed tonsillitis, we started taking this drug, on the second day I immediately saw an improvement, everything went away in just 4 days. I recommend it! There were no side effects!

Sveta

It is regularly prescribed to children for respiratory infections; I have not noticed any side effects.

Elena

I've been taking the pills for three days now - no changes. Apart from a sore throat. more swelling appeared. What’s confusing is that the manufacturer is the Netherlands, and it’s packaged in a village in the Kostroma region.

Anastasia

Helps children very well.

Sabir

I have a sensitive gastrointestinal tract. And I can’t take any antibiotics. But this drug saves me. There is some upset in the “stool”, but it is tolerable.

Zhenya

I really liked this drug. I took it for a terrible sore throat, the fever and bone fractures were relieved in the first dose of the drug.

Elena

I really liked this antibiotic! I treated myself with it, and I treated my two children (6 and 16 years old). There were no problems with the gastrointestinal tract or with the head! It is very important to me that this drug can be taken regardless of meals! Moreover, you can dilute it with water to the consistency of syrup (in 20 ml of water), and into a drink (in 100 ml of water), and take it in tablets! Flemoxin solutab has a very wide spectrum of action! I was treated with it for a severe cold, and my daughter for cystitis. It tastes good: sweet and fruity! The kids drank it without any problems! My family's treatment with this drug was successful! And I didn’t even have to take medications that restore intestinal microflora! He did not harm us, but only helped! I recommend!

Catherine

I took 7 tablets and started getting increasingly worse diarrhea. At the same time I take Acipol, because... I often have dysbacteriosis. What to do?

Nina

I started taking Flemoxin twice, and literally after the fifth tablet, severe headaches, indigestion and other side effects began. I do not recommend this drug to anyone, there is much more harm than good!

Elena

The whole family is treated with it. For the third year now he has been saving from severe complications. Bronchitis was cured in one course. I recommend!

Anna

The pediatrician prescribed it for my daughter! On the second day of treatment, the child’s condition began to improve! but I can’t say whether flemoxin helped or not! since in addition to it we took other drugs!

Marina

Excellent product, effective, helps immediately

Guest

But the drug does not have a positive effect on me. I’ve been taking it for four days and there’s no result, the fever still doesn’t go away, hoarseness, nasal congestion, cough.

Fields

My mother (62 years old) had some strange virus - first her throat, then her ear, then her throat again, three weeks on antibiotics and no results at all. Flemoxin Solutab worked great, in three days the swelling of the mucous membranes went away and the temperature returned to normal! The taste is not the most pleasant, but this is not so important.

Irina

I always try to prevent my child from getting sick, but if this happens, I am cured without strong drugs. And then they picked it up. My son began to roar, nothing helped, then the pediatrician said that we need to take these pills. They are soluble in water, drink normally, and have a citrus flavor. We read that they are suitable for children. They helped quickly, they took only 5 tablets and are healthy. Didn't give the slightest side effects.

Sergey

My therapist prescribed it for me to remove Helicobacter. He went well, only on the first day he felt a little sick. And my intestines were in order, but I also took probiotics along with it. There was also a caveat: not to take probiotics at the same time, either after or before flemoxin. I don't remember exactly.

Storage conditions and periods

The drug should be stored out of the reach of children at a temperature not exceeding 25°C.

Shelf life: 5 years.

Conditions for dispensing from pharmacies: the drug is available with a prescription.

We want to convert Special attention that the description of the antibiotic Flemoxin Solutab is presented for informational purposes only! To obtain more accurate and detailed information about the drug Flemoxin Solutab, we ask you to refer exclusively to the manufacturer’s annotation! Do not self-medicate under any circumstances! You should definitely consult a doctor before starting to use the drug!