home Audience 2 Directory of medicines. Aerosol "Polcortolon TS": composition, indications, instructions for use

Directory of medicines. Aerosol "Polcortolon TS": composition, indications, instructions for use

Instructions:

Clinical and pharmacological group

04.001 (GKS for oral administration)

Release form, composition and packaging

Tablets are white or almost white, round, flat, beveled, engraved with "O" on one side and "4/mg" on the other.

Excipients: potato starch, magnesium stearate, lactose.

25 pcs. - blisters (2) - cardboard packs.

pharmachologic effect

A synthetic glucocorticoid drug, is a fluorinated derivative of prednisolone. It has a strong anti-inflammatory effect and has a weak mineralocorticoid effect.

Inhibits the development of inflammatory symptoms by reducing capillary permeability and reducing the accumulation of macrophages, leukocytes and other cells in the inflammatory zone. Has an immunosuppressive effect, incl. due to suppression of the cellular immune response.

Suppresses the secretion of ACTH by the pituitary gland, which leads to a decrease in the production of GCS and androgens by the adrenal cortex.

Enhances protein catabolism, causes an increase in blood glucose concentration, affects lipid metabolism, increases concentration fatty acids in blood serum. At long-term treatment redistribution of adipose tissue is possible.

Triamcinolone inhibits education bone tissue and reduces the concentration of calcium in the blood serum, and therefore, while taking the drug, it is possible to suppress bone growth in children and adolescents and the development of osteoporosis in patients of all age groups.

4 mg of triamcinolone is considered to have anti-inflammatory effects equivalent to 4 mg of methylprednisolone, 5 mg of prednisolone, 0.75 mg of dexamethasone, 0.6 mg of betamethasone and 20 mg of hydrocortisone.

Pharmacokinetics

Suction

After oral administration, it is easily absorbed from the gastrointestinal tract. Bioavailability - 20-30%. Taking the drug with food slows down the absorption of triamcinolone in the initial phase, but does not affect the overall bioavailability of the drug.

Distribution

Binding to plasma proteins (mainly globulins) is 40%. Penetrates the placental barrier and is excreted breast milk.

Metabolism and excretion

Biotransformed mainly in the liver. The biological half-life is approximately 5 hours. It is excreted mainly by the kidneys in the form of inactive metabolites.

Dosage

They are set individually depending on the indications, the effectiveness of therapy and the patient’s condition.

It is recommended to take the entire daily dose 1 time/day in the morning with meals (in accordance with the daily rhythm of endogenous glucocorticoid secretion), but in some cases more may be necessary. frequent use drug.

Adults and adolescents over 14 years of age are prescribed a dose of 4-48 mg/day in 1 or several doses.

Children are prescribed the drug at a dose of 100-500 mcg/kg body weight/day in 1 or several doses.

If a dose is missed, the drug should be taken as quickly as possible. If the time is approaching next appointment, do not take the missed dose. Do not take a double dose at once.

Polcortolone should be prescribed at a minimum effective dose. If necessary, the dose of the drug can be gradually reduced.

Overdose

Symptoms: increased blood pressure, peripheral edema; it is possible to enhance the above side effects.

Treatment: gradual dose reduction and discontinuation of the drug; if necessary, carry out symptomatic therapy.

Taking large doses of the drug does not cause acute intoxication. But when long-term use Polcortolone, especially in large doses, there is a risk of overdose.

Drug interactions

With the simultaneous use of Polcortolone and cardiac glycosides, the risk of developing disorders increases heart rate and other toxic effects of glycosides associated with hypokalemia.

When used simultaneously with Polcortolone, barbiturates, anticonvulsants(phenytoin, carbamazepine), rifampicin, glutethimide accelerate the metabolism of triamcinolone (due to the induction of microsomal enzymes) and weaken its effect.

When used simultaneously, histamine H1 receptor blockers weaken the effect of Polcortolone.

At joint use Polcortolone with amphotericin B, carbonic anhydrase inhibitors increases the risk of hypokalemia, left ventricular myocardial hypertrophy and circulatory failure.

With simultaneous use of Polcortolone with paracetamol, the likelihood of hypernatremia, peripheral edema, increased calcium excretion increases, and the risk of hypocalcemia, osteoporosis, and hepatotoxicity of paracetamol increases.

When using Polcortolone together with anabolic steroids or androgens increases the risk of developing peripheral edema, acne (this combination requires caution, especially in the case of liver and heart diseases).

When used in combination, hormonal contraceptives containing estrogens enhance the effect of Polcortolone by increasing the concentration of globulins that bind corticosteroids in the blood serum, slowing their metabolism and increasing T1/2.

With simultaneous use of Polcortolone with anticholinergics (atropine), an increase in intraocular pressure.

Anticoagulants (coumarin derivatives, indanedione, heparin), streptokinase, urokinase reduce (in some patients increase) the effectiveness of Polcortolone. The dose should be determined based on prothrombin time and take into account the increased risk ulcerative lesion and bleeding from the gastrointestinal tract.

Concomitant use of tricyclic antidepressants may increase mental disorders associated with taking Polcortolone (this combination is not recommended).

With simultaneous use, Polcortolone weakens the effect of oral hypoglycemic drugs, insulin, increases the concentration of glucose in the blood (dosage adjustment of hypoglycemic drugs may be required).

When using Polcortolone and antithyroid drugs and hormones together thyroid gland Possible changes in thyroid function (dose adjustment or discontinuation of antithyroid drug or thyroid hormones may be required).

Polcortolone weakens the effect of potassium-sparing diuretics. Concomitant use may cause hypokalemia.

Polcortolone reduces the effectiveness of laxatives, thereby increasing the risk of hypokalemia.

When used simultaneously, ephedrine accelerates the biotransformation of triamcinolone, which may require dose adjustment of Polcortolone.

When using Polcortolone and immunosuppressants together, the risk of developing infections, lymphomas and other lymphoproliferative diseases increases.

When used together with isoniazid, a decrease in the concentration of isoniazid in the blood plasma may occur (mainly in individuals with rapid acetylation), in which case a dose change is necessary.

When used together, the metabolism of mexiletine accelerates and its concentration in the blood plasma decreases.

When used concomitantly with depolarizing muscle relaxants, hypocalcemia associated with the use of Polcortolone may increase the duration of neuromuscular blockade.

Polcortolone reduces the effect of NSAIDs (incl. acetylsalicylic acid), alcohol, which increases the risk of ulcerative lesions and bleeding from the gastrointestinal tract.

When using Polcortolone simultaneously with medications or foods containing sodium, peripheral edema and arterial hypertension. In such a situation, it is necessary to limit sodium in the diet and discontinue medications with a high sodium content.

When using vaccines containing live viruses against the background of immunosuppressive doses of GCS, viral replication and development of viral diseases, decreased antibody production (the combination is not recommended). When used simultaneously with other vaccines, the risk of neurological complications increases and the production of antibodies decreases.

When used together with folic acid the need for this drug may increase.

Use during pregnancy and lactation

The use of the drug during pregnancy is possible only in cases where the expected benefit to the mother outweighs the potential risk to the fetus.

If it is necessary to prescribe the drug during lactation, the issue of stopping breastfeeding should be decided.

Side effects

From the outside endocrine system: secondary adrenal and hypothalamic-pituitary insufficiency (especially in stressful situations such as illness, injury, surgical interventions), Itsenko-Cushing syndrome (including moon face, pituitary obesity, hirsutism, increased blood pressure, dysmenorrhea, amenorrhea, myasthenia gravis, stretch marks), delayed sexual development and growth suppression in children; violations menstrual cycle, decreased glucose tolerance, manifestation of latent diabetes mellitus and increased need for insulin or oral hypoglycemic drugs in patients with diabetes mellitus, hirsutism.

From the outside digestive system: steroid ulcer of the stomach and duodenum with possible perforation and bleeding, pancreatitis, erosive esophagitis, flatulence, digestive disorders, nausea, vomiting, increased or decreased appetite, hiccups; V in rare cases- increased activity of liver transaminases and alkaline phosphatase.

From the outside of cardio-vascular system: arrhythmias, bradycardia (up to cardiac arrest), development (in predisposed patients) or increased severity of chronic heart failure, ECG changes characteristic of hypokalemia, arterial hypertension, hypercoagulation, thrombosis. In patients with acute and subacute myocardial infarction, the necrosis focus spreads and the formation of scar tissue slows down, which can lead to rupture of the heart muscle.

From the central nervous system and peripheral nervous system: delirium, disorientation, euphoria, hallucinations, manic-depressive psychosis, depression, paranoia, increased intracranial pressure with nipple congestion syndrome optic nerve(pseudotumor cerebri - most often in children, usually after too rapid dose reduction; symptoms - headache, deterioration of visual acuity or double vision); vertigo, pseudotumor of the cerebellum, convulsions, dizziness, headache, nervousness or anxiety, sleep disturbance.

From the organ of vision: posterior subcapsular cataract, increased intraocular pressure with possible damage optic nerve, glaucoma, exophthalmos, tendency to develop secondary bacterial, fungal or viral infections eyes, trophic changes in the cornea.

Metabolism: negative nitrogen balance as a result of protein catabolism, hyperglycemia, glycosuria, increased calcium excretion, hypocalcemia, increased body weight, increased sweating, sodium and fluid retention in the body (peripheral edema), hypernatremia, hypokalemic syndrome (hypokalemia, arrhythmia, myalgia or muscle spasms, unusual weakness and fatigue).

From the outside musculoskeletal system: slower growth and ossification processes in children (premature closure of epiphyseal growth zones), osteoporosis (very rarely - pathological bone fractures, compression fracture spine, aseptic necrosis humeral head and femur, pathological fractures of long tubular bones), rupture of muscle tendons, muscle weakness, steroid myopathy, decreased muscle mass (atrophy).

Dermatological reactions: steroid acne, stretch marks, delayed wound healing, thinning of the skin, petechiae, ecchymoses, hematomas, a tendency to develop pyoderma and candidiasis.

Allergic reactions: skin rash, itching, anaphylactic shock.

Other: development and exacerbation of infections (the appearance of this side effect is facilitated by jointly used immunosuppressants and vaccination), leukocyturia, withdrawal syndrome.

The incidence and severity of side effects depend on the duration of their use, the size of the dose used and the ability to comply circadian rhythm appointments.

With short-term use of triamcinolone, like other corticosteroids, side effects are rarely observed. Side effects usually occur with long-term use of the drug.

Storage conditions and periods

List B. The drug should be stored in a dry place, protected from light, out of reach of children, at a temperature not exceeding 25°C. Shelf life - 3 years.

Indications

- endocrine diseases: adrenal insufficiency (primary or secondary), congenital hyperplasia adrenal glands, subacute thyroiditis;

- severe allergic diseases resistant to other treatment methods: contact dermatitis, atopic dermatitis, serum sickness, hypersensitivity reactions to medicines, year-round or seasonal allergic rhinitis;

— diseases of the musculoskeletal system: psoriatic arthritis, ankylosing spondylitis, acute and subacute bursitis, epicondylitis, acute tendovaginitis, post-traumatic osteoarthritis;

- rheumatic diseases: acute rheumatic fever, rheumatic myocarditis, rheumatoid arthritis, juvenile rheumatoid arthritis (in cases resistant to other treatment methods), polymyalgia rheumatica, Horton's disease;

— systemic diseases connective tissue: dermatomyositis, SLE, granulomatous giant cell mesoarteritis, systemic scleroderma, periarteritis nodosa, relapsing polychondritis;

— dermatological diseases: exfoliative dermatitis, bullous dermatitis herpetiformis, severe seborrheic dermatitis, heavy erythema multiforme(Stevens-Johnson syndrome), mycosis fungoides, pemphigus, severe psoriasis, severe forms eczema, pemphigoid;

- hematological diseases: acquired autoimmune hemolytic anemia, congenital (erythroid) hypoplastic anemia, anemia due to hypoplasia bone marrow, secondary thrombocytopenia in adults, idiopathic thrombocytopenic purpura (Werlhof's disease) in adults, hemolysis;

- liver diseases: alcoholic hepatitis with encephalopathy, chronic active hepatitis;

- hypercalcemia with malignant neoplasms;

— oncological diseases: leukemia and lymphoma in adults, acute leukemia in children;

— neurological diseases: tuberculous meningitis with subarachnoid block or with the threat of its occurrence (in combination with anti-tuberculosis therapy), multiple sclerosis during the period of exacerbation;

- severe acute and chronic inflammatory diseases of the eyes: severe sluggish anterior and posterior uveitis, optic neuritis, sympathetic ophthalmia;

- respiratory diseases: bronchial asthma(severe form), berylliosis, Loeffler's syndrome, symptomatic sarcoidosis, fulminant or disseminated pulmonary tuberculosis (in combination with anti-tuberculosis therapy), aspiration pneumonitis;

- for the prevention and treatment of graft rejection during organ and tissue transplantation (in combination with other immunosuppressive drugs).

Contraindications

- systemic mycoses;

- children under 3 years of age;

- hypersensitivity to the drug.

The drug should be prescribed with caution in the post-vaccination period (a period of 8 weeks before and 2 weeks after vaccination), with lymphadenitis after BCG vaccinations, in immunodeficiency conditions (including AIDS, HIV infection).

Caution should be exercised when treating persons with gastrointestinal diseases such as esophagitis, gastritis, UC with threat of perforation or abscess formation, diverticulitis, peptic ulcer stomach and duodenum, acute or latent peptic ulcer, a newly created intestinal anastomosis.

The drug is prescribed with caution to patients with diseases of the cardiovascular system, incl. when recently suffered a heart attack myocardium (in patients with acute and subacute myocardial infarction, the necrosis focus may spread, the formation of scar tissue may slow down and, as a result, the heart muscle will rupture), with chronic heart failure in the stage of decompensation, with arterial hypertension and hyperlipidemia.

Caution is required when prescribing Polcortolone to persons with endocrine diseases (diabetes/incl. with impaired carbohydrate tolerance/, thyrotoxicosis, hypothyroidism, Itsenko-Cushing's disease), with chronic renal and/or liver failure severe, nephrourolithiasis, with hypoalbuminemia and conditions predisposing to its occurrence, systemic osteoporosis, myasthenia gravis, acute psychosis, obesity III-IV degrees, poliomyelitis (except for the form of bulbar encephalitis), open- and closed-angle glaucoma, during pregnancy and lactation.

special instructions

In case of stressful situations For patients taking Polcortolone, parenteral administration of GCS is recommended.

Sudden cessation of treatment may cause the development of adrenal insufficiency, so the dose of Polcortolone should be reduced gradually.

Polcortolone may mask the symptoms of infection, reduce resistance to infection and the ability to limit its spread. Long-term use of Polcortolone increases the risk of developing secondary fungal or viral infections.

Long-term use of Polcortolone can cause the development of cataracts, glaucoma with possible defeat optic nerves.

Patients taking Polcortolone should not be vaccinated with live viral vaccines. Administration of an inactivated viral or bacterial vaccine may not produce the expected increase in antibodies. In addition, in patients taking GCS, there is increased risk neurological complications during vaccination.

It should be remembered that sudden cessation treatment may cause the development of adrenal insufficiency, so the dose of Polcortolone should be reduced gradually.

With the sudden withdrawal of Polcortolone, especially after long-term use, the development of the so-called withdrawal syndrome, manifested by anorexia, fever, muscle and joint pain, general weakness. These symptoms can appear even in cases where there is no adrenal insufficiency. In patients with hypothyroidism or liver cirrhosis, the effect of triamcinolone is enhanced.

During the use of Polcortolone, you may experience mental disorders, such as euphoria, insomnia, sudden mood changes, personality changes, severe depression, symptoms of psychosis. Pre-existing emotional instability or psychotic tendencies may increase during treatment.

When treating patients with hypoprothrombinemia, triamcinolone and acetylsalicylic acid should be prescribed simultaneously with caution.

Use in pediatrics

With long-term use of Polcortolone in pediatric practice, careful monitoring of the growth and development of children is necessary.

Use for renal impairment

Prescribe Polcortolon with caution when renal failure.

Use for liver dysfunction

Polcortolone should be prescribed with caution in case of liver dysfunction.

pharmachologic effect

Combination drug with anti-inflammatory and antibacterial effects for external use. Triamcinolone acetonide is a synthetic corticosteroid, a fluorine derivative of prednisolone, which has anti-inflammatory, antipruritic, antiexudative and antiallergic effects. Tetracycline hydrochloride is an antibiotic with a wide spectrum of bacteriostatic action, the mechanism of which is due to the ability to inhibit protein synthesis by microorganisms.

Pharmacokinetics

Data on the pharmacokinetics of the drug Polcortolone TS are not provided.

Indications

Allergic skin diseases complicated by secondary bacterial infection (including urticaria, atopic dermatitis, eczema);
- infectious and inflammatory skin diseases caused by microorganisms sensitive to tetracycline, as well as mixed infections (including impetigo, furunculosis, folliculitis, hidradenitis, erysipelas).

Dosage regimen

The affected areas of the skin are irrigated with a stream of aerosol for 1-3 seconds, holding the bottle in a vertical position at a distance of about 15-20 cm from the surface of the affected area of the skin.
For adults the procedure is carried out 2-4 times a day at regular intervals. The duration of therapy is determined individually and averages 5-10 days. If the disease persists, the course of treatment can be extended to 25 days. Use for more than 4 weeks is not recommended.
Children over 3 years of age the drug is prescribed for a short period of time, only 1 time/day and sprayed on small areas of the skin surface.

Side effect

Maybe: itching, skin irritation, purpura.
Rarely(with long-term use): development of secondary infectious lesions, acne, post-steroid vascular purpura, inhibition of epidermal growth, dry skin, hirsutism, pigmentation, skin atrophy, telangiectasia (usually when using occlusive dressings); photosensitivity.
With short-term use and when applied to small areas of the skin surface, the drug does not cause significant side effects.

Contraindications

Specific lesions skin: (including viral, fungal, tuberculous);
- tumors and precancerous conditions skin;
- skin manifestations of vaccination;
- glaucoma;
- violation of the integrity of the skin at the sites of application of the drug;
- children under 3 years of age;
- hypersensitivity to the components of the drug.

Pregnancy and lactation

Cannot be used in the first trimester of pregnancy. The use of Polcortolone TC in later stages of pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.
It is unknown how much topical triamcinolone acetonide is excreted in breast milk. When taking GCS orally, no significant amount of hormones were found in breast milk that could have an effect on the child. When prescribing Polcortolone TC during breastfeeding, the expected benefits for the mother and the risk of side effects in the child should be assessed. In exceptional cases, the drug is recommended for short-term use on limited areas of the skin and not on the skin of the mammary glands.
In experimental studies The teratogenic properties of the drug were revealed in animals.

special instructions

Use Polcortolon TS with extreme caution on the skin of the face, because... this increases the possibility of telangiectasias, skin atrophy, and perioral dermatitis even after short-term use.
Use with caution in persons with existing atrophic skin changes, especially in the elderly.
Prolonged use of the drug on a large surface of the skin should be avoided, because in this case, there is a risk of developing systemic side effects of GCS.
The patient should be warned about the need to stop using the drug and consult a doctor if skin irritation or other side effects occur.
Tetracycline, which is part of the drug, can cause photosensitivity, so you should protect the skin areas with the applied aerosol from direct contact. sun rays.
Long-term use of tetracycline, which is part of the drug Polcortolone TS, can increase the number of resistant strains of staphylococci, as well as Candida albicans (in this case, appropriate treatment is prescribed).
You should protect your eyes when spraying the aerosol; do not inhale the sprayed drug; If the drug accidentally gets into your eyes, they should be rinsed thoroughly. warm water.
The bottle must not be heated or opened; Do not spray the aerosol near an open fire.
Use in pediatrics
Polcortolone TS is not used in children under 3 years of age. The use of the drug in pediatric practice should be limited, since long-term use and high doses GCS can affect the growth and development of a child.

Overdose

Symptoms: with improper or prolonged use of the drug on large areas of the skin, the appearance of unwanted effects, characteristic of systemic use GCS.
Treatment: If necessary, carry out symptomatic therapy.
An overdose of Polcortolone TC when used externally is very rare.

Drug interactions

During treatment with GCS, vaccinations and immunizations should not be carried out due to disruption of the action of immunological drugs.

Storage conditions and periods

The drug should be stored out of the reach of children at temperatures up to 25°C. Shelf life - 2 years.

Immunosuppressive, hormonal anti-inflammatory drug Polcortolone is a derivative of Prednisolone, has an immunosuppressive effect, is used in the treatment of children and adults, and is allowed during pregnancy after 3 months under the supervision of a doctor. Today we will review the instructions for using Polcortolon tablets, ointments, aerosols, price, reviews and analogues of the medicine.

Features of the drug

The drug Polcortolon (Poland) is a glucocorticoid and is used to treat a wide range of allergic and dermatological diseases.

Composition of Polcortolone

Dosage forms

Tablet Polcortolone contains 4 mg triamcinolone. The drug is packaged in blisters of 25 tablets. The cost of the medicine in tablets ranges from 356 to 435 rubles in Moscow pharmacies.
Ointment Polcortolon, 0.1% - white transparent fatty mass. The drug is packaged in 15 g aluminum tubes, the price of the ointment is 290 - 315 rubles.
Aerosol (spray) Polcortolone TS 30 ml, contains 0.4 g of triamcinolone and 0.01 g of tetracycline. The drug is used for external use, the price is 414 rubles.

pharmachologic effect

The glucocorticosteroid triamcinolone has an anti-inflammatory and immunosuppressive effect.

Pharmacodynamics

The action of the drug Polcortolone is based on immunosuppressive properties hormonal drug triamcinolone, which manifests itself:

blocking the release of interleukins 1, 2, interferon;
stabilization of mast cells;
release of lipocortins;
preventing the release of inflammatory mediators from eosinophils.

This leads to a decrease in capillary permeability, eliminating allergic edema, reduction of inflammatory phenomena.

Pharmacokinetics

The drug Polcortolone is well absorbed in the stomach, is able to penetrate the placenta, and appears in breast milk during lactation. The therapeutic effect lasts 8 hours.

When applied externally, triamcinolone does not have a systemic effect. Triamcinolone accumulates in the skin, is processed in the liver, and is excreted in the urine. The half-life is 5 hours.

Indications

Tablets and suspension

Tablets and injection suspension are used to treat:

diseases of the endocrine system:
- adrenal hyperplasia;
- thyroiditis;
allergic diseases:
- dermatitis – , ;
- drug allergies;
- serum sickness;
- allergic rhinitis;
dermatological diseases:
- pemphigus;
musculoskeletal disorders:
- psoriatic arthritis;
- bursitis;
- tenosynovitis;
- spondyloarthritis;
- osteoarthritis;
rheumatic pathologies:
- arthritis;
- polymyalgia;
hematological diseases:
- hemolytic anemia;
- hypoplastic anemia;
- thrombocytopenia;
- thrombocytopenic purpura;
- hepatitis – chronic;
- oncological diseases – , ;
- severe forms of eye diseases - uveitis, sympathetic ophthalmia;
- pulmonary tuberculosis.

Ointment

The ointment is used against:

pruritus;
eczema;
strophulus;
insect bites.

Aerosol

In dermatology, Polcortolone TS aerosol is widely used for therapy:

atypical dermatitis, eczema, complicated by bacterial infection;
, erysipelas caused by staphylococcal, streptococcal infections.

Instructions for use

Pills

The daily dose is taken once in the morning. As prescribed by a doctor, a regimen of several doses (2-3) of the drug may be recommended.

For adults, teenagers from 14 years old daily dosage- from 4 to 20 mg, for children over 3 years of age the dosage is calculated as 0.5 mg - 1 mg per 1 kg of weight.

For rheumatic exacerbations – daily dose at first it is 12-20 mg. After a week it is reduced to 2-12 mg.
At allergic diseases the initial dosage is 8-16 mg. After a week it is reduced to 1-10 mg.
At oncological diseases the daily dose can be up to 75 mg.

If a dose of Polcortolone is accidentally missed, a double dose should not be taken.

Aerosol

Used from 3 years of age, prohibited during pregnancy in the 1st trimester. In later stages, as well as during lactation, the use of an aerosol for treating the skin is allowed only as prescribed by a doctor.
For adults, treat the affected areas of the skin for 3 seconds from a distance of 20 cm up to 4 times a day for 5-10 days. The course should not exceed 28 days.
Treatment for children is prescribed in short courses, the product is applied to small areas of the skin. You need to treat your skin no more than once a day.

Ointment

In the first days of treatment for adults, the ointment is applied 2-3 times a day to the skin with rubbing movements. After a few days, the ointment is applied no more than 1-2 times a day. The duration of the course should not exceed 14 days, and when treating facial skin - 7 days.

For keratosis, lichenification (thickening of the skin in the area of the rash), it can be used under an occlusive (sealed) bandage, which is applied for 1-2 days.
Children over 2 years old can apply the ointment no more than once a day, without touching the face, treating only small areas.

This video will also talk about the use of Polcortolone for the treatment of bronchial asthma:

Contraindications

Polcortolone is contraindicated for fungal diseases and individual sensitivity. Relative contraindications are diabetes, osteoporosis.

Products for external use are contraindicated for diseases:

cancer, ;
trophic ulcers;
rosacea, vulgar acne;

The drug is contraindicated in children:

tablets – up to 3 years;
aerosol - up to 3 years;
ointment - up to 2 years.

During pregnancy, the ointment is not prescribed in the first trimester, and in subsequent stages of pregnancy and lactation with caution and only in small areas, excluding the mammary glands.

Side effects

Side effects when treating children with the drug may include delayed growth and development. With prolonged use of the drug, side effects increase in a dose-dependent manner.

The use of Polcortolone in tablets can provoke the development of:

, perforated ulcer stomach, appetite disturbances, purpura, skin irritation, bruising,
paracetamol - increases the likelihood of swelling of the limbs, osteoporosis;
immunosuppressants – the risk of secondary infection increases;
hormonal drugs - the risk of thyroid diseases when using antithyroid drugs, edema, acne when using anabolic steroids.

Aspirin should be used with caution in patients suffering from hypoprothrombinemia during treatment with Polcortolone.
Dietary use should be limited table salt due to the fact that sodium salts during treatment with Polcortolone can provoke edema.
The effect of treatment with Polcortolone tablets increases with use hormonal contraceptives, and is weakened by the use of barbiturates, rifampicin, carbamazepine, glutethimide.

Why is Polcortolon TS aerosol needed? Indications for the use of the mentioned remedy will be listed below. You will also learn how it works this drug, in what cases it cannot be prescribed and how much it costs.

Composition, packaging, description

"Polcortolon" - spray for external use. It is produced in the form of a homogeneous yellow suspension with a characteristic odor and without mechanical inclusions. Its main active ingredients are triamcinolone acetonide. The aerosol also contains: a mixture of butane, propane and isobutane, sorbitan trioleate, isopropyl myristate and lecithin.

This product is sold in 30 ml aerosol bottles made of aluminum, with a spray device and a constant valve.

Pharmacological characteristics of the external preparation

What is the topical aerosol in question? The instructions state that the pharmacological effectiveness of this drug is due to its composition.

Triamcinolone acetonide is a synthetic glucocorticosteroid, as well as a fluorine derivative of prednisolone, which exhibits pronounced antipruritic, anti-inflammatory, antiexudative and antiallergic properties.

As for tetracycline hydrochloride, it is a broad-spectrum antibiotic. It can have a bacteriostatic effect, which manifests itself due to the suppression of protein synthesis by microorganisms.

Kinetic features of the spray

Is Polcortolon TS external aerosol absorbed? When applied to the skin, tetracycline has only a local effect and practically does not penetrate the systemic bloodstream.

When triamcinolone is used externally, it may enter the systemic circulation slightly. It should be noted that various diseases skin and inflammatory process significantly accelerate the absorption of this drug.

Triamcenolone is metabolized in the liver and excreted through the kidneys.

Indications for use of the spray

For what purpose are patients prescribed Polcortolone TS aerosol? According to the instructions, this product for external application is actively used for allergic diseases skin that is complicated by secondary bacterial infection (for example, urticaria, atopic dermatitis or eczema).

It should also be noted that this medication performs well in skin diseases caused by microorganisms sensitive to tetracycline, as well as in mixed infections (that is, it treats impetigo, hidradenitis suppurativa, furunculosis, erysipelas, folliculitis and others).

Prohibitions for use

The medicine for urticaria "Polcortolon PS" should not be used for:

skin tuberculosis;
chicken pox;
syphilis (skin manifestations);
during the vaccination period;
viral, fungal skin infections;
violation of the integrity of the skin at the sites of application of the medicine;
hypersensitivity to medication substances;
precancerous conditions and tumors of the skin;
V childhood up to three years.

It should also be noted that the medicine in question is prescribed with caution for glaucoma.

The drug "Polcortolon": instructions for use

Spray "Polcortolon PS" is intended for external use only. Before using the medicine, the bottle should be shaken well.

The affected skin areas are irrigated with a generous stream of aerosol for three seconds. In this case, the bottle is kept in a vertical position at a distance of approximately 15-22 centimeters from the surface of the integument. For adult patients, this procedure is performed 4 times a day after an equal amount of time. The duration of therapy is determined in individually and is about 5-11 days. If the disease persists, the course of treatment can be extended to 20 days. It is highly not recommended to take this drug for more than 4 weeks in a row.

For children over the age of three years, the medication in question is prescribed for a short time, once a day. When sprayed only on small surfaces of the skin.

Side effects

With short-term use, the drug for urticaria "Polcortolone PS" does not cause side effects. The same applies to its application to small areas of skin.

Sometimes, while using this drug, patients may develop: skin irritation, itching and purpura. Also very rarely (when applied and long-term use) aerosol "Polcortolon PS" contributes to the occurrence of acne, secondary infectious lesions, post-steroid vascular purpura, dry skin, inhibited epidermal growth, increased hair growth, skin atrophy, pigmentation, telangiectasia and photosensitivity.

With long-term use of glucocorticosteroids on large surfaces of the skin, the incidence of side effects in the form of arterial hypertension, hyperglycemia, edema (peripheral) and immunosuppressive effect increases significantly.

Overdose and drug interactions

An overdose of the drug in question when used externally occurs very rarely. In this case, it is possible that undesirable symptoms may appear with prolonged or improper use of the spray on large areas of the skin, which are similar to the adverse reactions characteristic of the systemic use of glucocorticosteroids with inhibition of pituitary-adrenal function.

Concerning drug interactions, then it has not been established for this drug.

Lactation and pregnancy period

"Polcortolone" is a spray that should not be prescribed in the first trimester of pregnancy. As for its use at a later stage, it is only possible if the benefit of the drug for the mother significantly exceeds the likely risk of complications for the fetus.

It should also be noted that it is still unknown to what extent triamcinolone acetonide is excreted in breast milk. Therefore, when prescribing this drug to nursing mothers, special care must be taken. In this case, the medication should be used for a short time and on limited areas of the skin. Do not spray the aerosol onto the mammary glands.

Special Information

With the development of skin diseases (hidradenitis suppurativa, urticaria, furunculosis and others), this drug is used for a short time. It is used with extreme caution on the skin of the face, since its absorption increases significantly and the likelihood of side effects (skin atrophy, telangiectasia and perioral dermatitis) increases.

Also, the Polcortolon PS spray should be used with caution in people with existing atrophic changes in the skin, especially in the elderly.

If skin irritation or other adverse reactions it is necessary to interrupt therapy and immediately consult a doctor.

Long-term use of tetracycline, which is part of the drug in question, may increase the number of resistant strains of Candida albicans and staphylococci. In this case, appropriate treatment is required.

During therapy with glucocorticosteroids, immunization and vaccination are prohibited.

The tetracycline contained in the aerosol may contribute to the development of photosensitivity. In this regard, it is necessary to protect the skin areas with the applied drug from direct sunlight.

Also, when spraying the aerosol, you should carefully protect your eyes and nose (the sprayed drug should not be inhaled). If the medication gets into visual organs they must be rinsed thoroughly with warm water, otherwise it may cause glaucoma.

The product in question is not used in children under three years of age. The use of the drug in children over this age should be limited, since high doses of corticosteroids and their long-term use can affect the development and growth of the child.

The drug "Polcortolone PS" does not limit the patient's psychophysical activity, as well as his ability to drive a car and maintain any moving mechanisms.

Spray "Polcortolon": price, consumer reviews

The cost of the aerosol in question is quite high. As a rule, it is about 450 rubles per bottle. But despite this, most patients choose this drug. They attribute such popularity of the drug to its high effectiveness.

This remedy has proven itself in the treatment of various skin diseases allergic nature, as well as diseases caused by microorganisms sensitive to tetracycline. It should be noted that the therapeutic effectiveness of Polcortolone PS is manifested only with its correct and short-term use and only as prescribed by a doctor.

Polcortolone, the instructions for use of which will now be discussed, is a drug included in the group of glucocorticoid drugs intended for the treatment of a wide range of pathological conditions.

What are the composition and release form of Polcortolon?

Active substance in the drug Polcortolone is represented by triamcinolone, the amount of which is 4 milligrams per tablet and 1 mg per gram of ointment.

Ointment excipients: anhydrous lanolin, white petrolatum, propylene glycol, citric acid. In tablets, in addition to active component, the following chemicals are found: lactose, potato starch, magnesium stearate.

The drug Polcortolone is available in round, flat tablets with the designation “O” on one side and “4mg” on the other, sold in packs of 25 pieces. In addition, a white ointment with a fatty base is produced, sold in aluminum tubes of 15 grams. Both forms of pharmaceuticals are sold by prescription.

What is the effect of Polcortolon?

Synthetic glucocorticoid, fluorinated derivative of prednisolone. The drug has a pronounced anti-inflammatory effect, which is based on a significant number of biochemical processes.

The mechanism of action of the drug is based on the suppression of the processes of synthesis of inflammatory mediators (prostaglandins and leukotrienes), due to the inactivation of cyclooxygenase and phospholipase (enzymes responsible for the formation of these substances).

Reducing the content of mediators inflammatory reaction leads to the appearance of many positive changes, first of all, the permeability of the capillary wall decreases, which is expressed in the elimination of edema in the affected areas of the body.

The drug suppresses the body's immune response mainly due to inactivation of its cellular component. This action is based on the suppression of macrophage activity, and so on. The number of circulating lymphocytes in the peripheral blood also decreases due to their migration into the lymphoid tissue.

Triamcinolone is able to evade the catabolic links of metabolism. Under the influence of the active component, glucose is released, and therefore its concentration in the blood increases. Lipolysis reactions lead to an increase in the content of fatty acids and so on.

The processes of bone tissue renewal are suppressed. In this regard, the likelihood of spontaneous fractures occurring as a result of normal loads increases significantly.

Long-term use of the drug, due to the mechanism feedback, suppresses the secretion of adrenocorticotropic hormone, which leads to suppression of the production of endogenous glucocorticoids.

When taken orally, triamcinolone is quickly absorbed from the intestine, but the bioavailability coefficient is not too high, no more than 30 percent, in some cases even lower.

When using ointment, the effective concentration active substance is formed only in the stratum corneum of the skin. Penetrates into the systemic circulation in small quantities

Distribution across tissues is relatively uniform. Triamcinolone penetrates through most histissue barriers. The active substance of the drug is detected in practically all organs. Biotransformation takes place in the liver. Excretion is carried out in the urine in the form of inactive metabolites.

What are Polcortolon's indications for use?

Polcortolone tablets, ointment instructions for use allow use in medicinal purposes V following cases:

Dermatitis of various etiologies, including allergic, seborrheic contact and so on (ointment);
Eczema (ointment);
Insect bites (ointment);
Erythema multiforme (ointment);
Rheumatic diseases (tablets);
Adrenal insufficiency (tablets);
Inflammatory diseases musculoskeletal system (tablets);
Connective tissue disease (tablets);
Leukemia and lymphoma in adults (tablets);
Hypercalcemia;
Anemia of various origins(pills);
Prevention of transplant rejection reactions (tablets).

In addition, the medication can be used only after consultation with a specialist and determination of effective dosages.

What are the contraindications for use of Polcortolon?

Polcortolone ointment, tablets, instructions for use do not allow use for medicinal purposes in the following cases:

Infectious diseases;
Skin neoplasms (ointment);
Acne vulgaris(ointment);
Ages up to 2 years (ointment) and up to 3 years (tablets);
Increased sensitivity to triamcinolone.

In addition, during pregnancy and lactation (tablets).

What are the uses and dosage of Polcortolon?

The ointment is applied in a thin layer, trying to cover the entire affected area of the body, after which the medicine is gently rubbed in. Occlusive dressings can only be used in the presence of severe keratosis. On initial stage treatment, the medicine is used 2 to 3 times a day, as the condition stabilizes - 1 time a day. The maximum duration of treatment is 3 weeks.

The dosage of tablet dosage forms of the drug Polcortolone is very variable and depends on body weight, diagnosis, severity of the condition, the presence of concomitant pathology, etc., age and many other factors. Effective dosage ranges from 4 to 48 mg per day.

However, there are general recommendations. It is better to take the medicine once a day, in the morning, preferably during meals, which will reduce the load on the gastric mucosa. IN severe cases perhaps more frequent use drug. The duration of treatment is determined by the doctor's opinion.

Polcortolone - drug overdose

Symptoms are: peripheral edema, symptoms feeling unwell, increase blood pressure, headache, in addition, vomiting. Treatment is symptomatic; there is no specific antidote, the suppressive effect of triamcinolone.

What are the side effects of Polcortolon?

The use of the drug Polcortolone can cause the following side effects: Itsenko-Cushing syndrome, delayed sexual development, decreased glucose tolerance, secondary adrenal insufficiency, peptic ulcer disease of the stomach and intestines, pancreatitis, hepatitis, decreased visual acuity, damage to the optic nerve, dizziness, convulsions, disorders sleep, anxiety, tendon ruptures, anaphylactic shock, and frequent infectious diseases.

How to replace Polcortolon, what analogues should I use?

Triamsinolon, triamcinolone nicemed, Kenalog 40, fluerma, fluorocort, Polkortolon 40, triamcinolone acetonide, kenacort, nasacort, Delphort, Tsinacort, Berlicort, Trimsinolon Acetonide, Triam Dod, Triamcinolon, Triacort, Tricort, Kenalog Orange, Triamzi Nolon-FPO, Kenalog ( The instructions for use of each drug before use must be studied personally from the official annotation included in the package!).

Conclusion

To prevent negative consequences it is necessary to strictly adhere to the recommended treatment periods and dosages of the medication. This is especially true for the use of tablet forms of the drug.