Thiogamma analogues and prices. Is there something cheaper and better than Tiogamma? Review of analogues and comparison of drugs
Thiogamma is a drug with antioxidant and metabolic effects that regulates carbohydrate and lipid metabolism.
The active ingredient of the drug is thioctic (alpha-lipoic) acid. It is an endogenous antioxidant that binds free radicals. Thioctic acid is formed in the body during the oxidative decarboxylation of alpha-keto acids.
Thioctic acid regulates carbohydrate and lipid metabolism, improves liver function and stimulates cholesterol metabolism. It has hypolipidemic, hypoglycemic, hepatoprotective and hypocholesterolemic effects. Helps improve neuron nutrition.
Alpha -lipoic acid helps reduce blood glucose levels, increase the concentration of glycogen in the liver and overcome insulin resistance. According to the mechanism of action, it is close to B vitamins.
In studies on rats with streptozotocin-induced diabetes, thioctic acid was shown to reduce the formation final products glycation, improves endoneurial blood flow, increases the level of physiological antioxidants such as glutathione. Experimental data indicate that thioctic acid improves the functions of peripheral neurons.
This concerns sensory disturbances at diabetic polyneuropathy, such as dysesthesia, paresthesia (burning, pain, crawling sensation, decreased sensitivity). Effects confirmed by multicenter clinical studies, carried out in 1995
Forms of release of the drug:
- Tablets – 600 mg each active substance in each;
- Solution for parenteral administration 3%, ampoules of 20 ml (1 ampoule contains 600 mg of active substance);
- Thiogamma-turbo – solution for parenteral infusions 1.2%, 50 ml bottles (1 bottle contains 600 mg of active substance).
Indications for use
What does Tiogamma help with? The drug is prescribed in the following cases:
- Fatty liver degeneration ( fat disease liver);
- Hyperlipidemia of unknown origin ( increased content fats in the blood);
- Toadstool poisoning (liver toxicity);
- Liver failure;
- Alcoholic liver disease and its consequences;
- Hepatitis of any origin;
- Hepatic encephalopathy;
- Cirrhosis of the liver.
Instructions for use of Thiogamma, dosage
The tablets are taken orally, on an empty stomach, with a small amount of liquid.
During the year, the course of treatment can be repeated 2-3 times.
Injections
The drug is administered intravenously at a dose of 600 mg/day (1 amp. concentrate for preparing a solution for infusion 30 mg/ml or 1 bottle of solution for infusion 12 mg/ml).
When performing an intravenous infusion, the drug should be administered slowly, at a rate of no more than 50 mg/min (which is equivalent to 1.7 ml of concentrate for preparing a solution for infusion of 30 mg/ml).
Prepare infusion solution– the contents of one ampoule of concentrate should be mixed with 50-250 ml of 0.9% sodium chloride solution. The bottle with the prepared solution is covered with a light-protective case that comes with the drug. The prepared solution can be stored for no more than 6 hours.
If a ready-made infusion solution is used, the bottle of medicine is removed from the box and immediately covered with a light-protective case. Administration is carried out directly from the bottle, slowly - at a rate of 1.7 ml/minute.
Side effects
Prescription of Thiogamma may be accompanied by the following side effects:
From the outside digestive system: when taking the drug orally - dyspepsia (including nausea, vomiting, heartburn).
- From the side of the central nervous system: rarely (after intravenous administration) – convulsions, diplopia; at rapid introduction– increase intracranial pressure(a feeling of heaviness in the head).
- From the blood coagulation system: rarely (after intravenous administration) - pinpoint hemorrhages in the mucous membranes, skin, thrombocytopenia, hemorrhagic rash (purpura), thrombophlebitis.
- From the outside respiratory system: With rapid intravenous administration, breathing difficulties may occur.
- Allergic reactions: urticaria, systemic reactions (up to the development anaphylactic shock).
- Other: hypoglycemia may develop (due to improved glucose absorption).
Contraindications
Thiogamma is contraindicated in the following cases:
- children's and adolescence up to 18 years old;
- pregnancy period;
- breastfeeding period;
- glucose-galactose malabsorption, lactase deficiency, hereditary intolerance galactose (for tablets);
- hypersensitivity to the main or auxiliary ingredients of the drug.
While using the drug, you should not take alcoholic beverages, since under the influence of ethanol the likelihood of developing severe complications from the nervous system and digestive tract.
Prices in Moscow pharmacies: Thiogamma solution 12 mg/ml 50 ml – from 197 to 209 rubles. Tablets 600 mg 30 pcs. – from 793 to 863 rubles.
Store out of reach of children, protected from light, at temperatures up to 25 °C. Shelf life – 5 years. Available in pharmacies by prescription.
(the second name is alpha lipoic).
The main active ingredient is an antioxidant required by the body for proper life support.
Diseases for which use is indicated: alcoholic injuries to nerve trunks, severe intoxication of the body. The body produces some of this acid on its own, but over the years the level of production decreases and the need increases. Supplementing with alpha lipoic acid helps treat diseases and improve quality of life.
Thioctic acid preparations are available in the form of tablets, rectal suppositories, a ready-made solution for injection and a concentrated substance for preparing a solution. Medicines based on alpha-lipoic acid are dispensed from pharmacies only with a doctor's prescription.
Analogs of Thiogamma are produced pharmaceutical companies several countries. Let's list the ones that are common in our market.
Russian analogues:
- Korilip;
- Korilip-Neo;
- Lipoic acid;
- Lipothioxone;
- Thiolepta.
Foreign analogues:
- 300 (Germany);
- Berlition 600 (Germany);
- Neurolipon (Ukraine);
- Thioctacid 600 T (Germany);
- Thioctacid BV (Germany);
- Espa-Lipon (Germany).
What's better?
Thiogamma or Thioctacid?
Thioctacid is similar drug, based on the same active ingredient.
The range of application of Thioctacid is appropriate:
- treatment of neuropathies;
- liver diseases;
- fat metabolism disorders;
- atherosclerosis;
- intoxications;
- metabolic syndrome.
After examining the patient and establishing a specific diagnosis, the doctor draws up a dosage regimen for the drug. As a rule, treatment begins with intravenous administration of ampoules pharmacological drug Thioctacid 600 T 1600 mg for 14 days, followed by oral administration Thioctacid BV 1 tablet per day before meals.
The BV (quick release) form can replace intravenous injections, since it allows for increased digestibility of the active ingredient. The duration of treatment is long, since the body needs to constantly receive the active substance to ensure full functioning.
Thioctacid tablets
At intravenous use The speed at which the medicine enters the body is important. One ampoule is administered for 12 minutes, since the recommended rate of administration of the drug is 2 ml per minute. Thioctic acid reacts to light, so the ampoule is removed from the package only before use.
For convenient administration, Thioctacid can be used in diluted form. To do this, an ampoule of the drug is dissolved in 200 ml of physiological solution, the bottle is protected from sunlight and injected into the bloodstream over 30 minutes. While maintaining adequate protection from sun rays diluted Thioctacid is stored for 6 hours.
An overdose has been observed with increased doses of the drug, resulting in intoxication. This is indicated by nausea, vomiting, headache, multiple organ failure syndrome, thrombohemorrhagic syndrome, hemolysis and shock.
Consumption during the treatment phase is contraindicated because it leads to severe poisoning, convulsions, fainting, possible death.
If the listed signs are detected, timely hospitalization and in-hospital actions aimed at deintoxication are necessary.
When performing an infusion of Thioctacid 600 T, negative side effects appear when the drug is administered hastily.
Convulsions may occur, possibly increased intracranial pressure, and apnea. If the patient has an individual intolerance to the drug, then allergic reactions are inevitable, for example, skin rashes, itching, anaphylaxis, angioedema. There is a possibility of impaired platelet function, sudden bleeding, and pinpoint hemorrhage on the skin.
When taking Thioctacid BV tablets, patients are sometimes bothered by digestive disorders: nausea, vomiting, gastralgia, intestinal dysfunction. Due to the property of Thioctacid to bind metal ions and individual trace elements, taking it together with preparations of iron, calcium, magnesium or entire vitamin-mineral complexes is contraindicated.
People taking or taking medications to lower blood sugar should remember that thioctic acid increases the rate of glucose utilization, so you need to carefully monitor your sugar levels and adjust the dosage of glucose-lowering substances.
Due to the occurrence of sparingly soluble chemical compounds, Thioctacid is not mixed with Ringer's solutions, monosaccharides and solutions of sulfide groups.
Compared to Thiogamma, Thioctacid has much fewer contraindications, which include only breastfeeding, childhood and individual intolerance to the components of the drug.
Tiogamma or Berlition?
The manufacturer of the analogue is registered in Germany; the active substance is purchased in China. There is a misconception that Berlition is much more profitable in financially, however this is not true.
Berlition in ampoules
The release form is ampoules and tablets with a dosage of 300 mg; the number of tablets in the package is much smaller, which means that to obtain a therapeutic daily dose of alpha-lipoic acid, you have to use double the amount of medication. Consequently, the cost of the course increases.
Thiogamma or Octolipen?
Analogue Russian production at an attractive price per package. But when calculating the cost of the course, it becomes clear that the price of treatment is at the level of more expensive treatments.
The scope of application of Octolipen is much smaller, since it has only two indications for use - diabetic and alcoholic polyneuropathy.
By biochemical properties similar to B vitamins.
Thiogamma: instructions for use and reviews
Latin name: Thiogamma
ATX code: A16AX01
Active substance: Thioctic acid
Manufacturer: Verwag Pharma GmbH and Co. KG (Worwag Pharma GmbH & Co. KG), Böblingen, Germany
Updating the description and photo: 02.05.2018
Thiogamma is a drug that regulates lipid and carbohydrate metabolism.
Release form and composition
- solution for infusion: transparent, light yellow or yellowish-green (50 ml in a dark glass bottle, 1 or 10 bottles in a cardboard box);
- concentrate for the preparation of a solution for infusion: a transparent yellowish-green solution (20 ml in a dark glass ampoule, 5 ampoules in a tray, 1, 2 or 4 trays in a cardboard box);
- Film-coated tablets: oblong, convex on both sides, light yellow in color with white and yellow splashes varying intensity, with risks on both sides; a cross-section shows a light yellow core (10 pieces in a blister, 3, 6 or 10 blisters in a cardboard box).
Active substance – thioctic acid:
- 1 ml of solution – 12 mg (600 mg in 1 bottle);
- 1 ml of concentrate – 30 mg (600 mg in 1 ampoule);
- 1 tablet – 600 mg.
Excipients:
- solution: macrogol 300, meglumine, water for injection;
- concentrate: macrogol 300, meglumine, water for injection;
- tablets: colloidal silicon dioxide, croscarmellose sodium, microcrystalline cellulose, simethicone (dimethicone and colloidal silicon dioxide in a ratio of 94:6), lactose monohydrate, talc, magnesium stearate, hypromellose; shell composition: hypromellose, sodium lauryl sulfate, talc, macrogol 6000.
Pharmacological properties
Pharmacodynamics
The active ingredient of the drug is thioctic (alpha-lipoic) acid. It is an endogenous antioxidant that binds free radicals. Thioctic acid is formed in the body during the oxidative decarboxylation of alpha-keto acids. It is a coenzyme of multienzyme complexes in mitochondria and is involved in the oxidative decarboxylation of alpha-keto acids and pyruvic acid.
Alpha lipoic acid helps reduce blood glucose levels, increase glycogen concentrations in the liver and overcome insulin resistance. According to the mechanism of action, it is close to B vitamins.
Thioctic acid regulates carbohydrate and lipid metabolism, improves liver function and stimulates cholesterol metabolism. It has hypolipidemic, hypoglycemic, hepatoprotective and hypocholesterolemic effects. Helps improve neuron nutrition.
When using megluminic salt of alpha-lipoic acid (has a neutral reaction) in solutions for intravenous administration side effects can be reduced.
Pharmacokinetics
At oral administration thioctic acid is quickly and completely absorbed from gastrointestinal tract. At simultaneous administration With food, absorption of the drug is reduced. Bioavailability is 30%. To achieve the maximum concentration of the active substance, it takes from 40 to 60 minutes.
Thioctic acid undergoes a first-pass effect through the liver. Metabolized in two ways: by conjugation and by oxidation of the side chain.
The volume of distribution is approximately 450 ml/kg. Up to 80–90% dose taken excreted by the kidneys in the form of metabolites and unchanged. The half-life ranges from 20 to 50 minutes. The total plasma clearance of the drug is 10–15 ml/min.
The time to reach maximum plasma concentration with intravenous administration of Thiogamma is 10–11 minutes, and maximum concentration in plasma – 25–38 mcg/ml. AUC (area under the concentration-time curve) is approximately 5 mcg/h/ml.
Indications for use
Thiogamma is a drug intended for the treatment of polyneuropathy (diabetic and alcoholic).
Contraindications
- hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption (for tablets);
- age under 18 years;
- pregnancy;
- period breastfeeding;
- hypersensitivity to the components of the drug.
Instructions for use of Thiogamma: method and dosage
Solution for infusion and concentrate for the preparation of solution for infusion
The solution, including those prepared from concentrate, is administered intravenously.
The daily dose of Thiogamma is 600 mg (1 bottle of solution or 1 ampoule of concentrate).
The drug is administered over 30 minutes (at a rate of about 1.7 ml per minute).
Preparation of a solution from the concentrate: mix the contents of 1 ampoule with 50–250 ml of 0.9% sodium chloride solution. Immediately after preparation, the solution should be immediately covered with the included light-protective case. Store for no more than 6 hours.
When using the prepared solution, remove the bottle from the cardboard packaging and immediately cover it with a light-protective case. The infusion should be carried out directly from the vial.
The duration of treatment is 2–4 weeks. If it is necessary to continue therapy, the patient is transferred to the tablet form of the drug.
Film-coated tablets
The tablets should be taken orally on an empty stomach: swallowed whole and washed down with sufficient liquid.
The duration of treatment, depending on the severity of the disease, is 30–60 days.
If necessary, repeated courses can be conducted 2-3 times a year.
Side effects
Solution and concentrate
- from the outside endocrine system: decreased blood glucose concentration (visual disturbances, increased sweating, dizziness, headache);
- from the central nervous system: disturbance or change taste sensations, convulsions, epileptic seizure;
- from the hematopoietic system: hemorrhagic rash (purpura), thrombocytopenia, thrombophlebitis, pinpoint hemorrhages in the skin and mucous membranes;
- from the skin and subcutaneous tissue: eczema, itching, rash;
- from the organ of vision: diplopia;
- allergic reactions: urticaria, systemic reactions (discomfort, nausea, itching) up to the development of anaphylactic shock;
- local reactions: hyperemia, irritation, swelling;
- other: in case of rapid administration of the drug - difficulty breathing, increased intracranial pressure (a feeling of heaviness in the head occurs).
Film-coated tablets
Thiogamma is generally well tolerated. Rarely, including isolated cases, the following occur: side effects:
- allergic reactions: urticaria, skin rash, itching, systemic reactions up to the development of anaphylactic shock;
- from the digestive system: abdominal pain, nausea, diarrhea, vomiting;
- from the endocrine system: decreased concentration of glucose in the blood (visual disturbances, increased sweating, dizziness, headache).
Overdose
An overdose of thioctic acid causes the following symptoms: headache, nausea and vomiting. When taking 10–40 g of Thiogamma in combination with alcohol, cases of severe intoxication, even death, have been reported.
In case of an acute overdose of the drug, confusion or psychomotor agitation occurs, usually accompanied by lactic acidosis and generalized convulsions. Cases of hemolysis, rhabdomyolysis, hypoglycemia, and depression have been described. bone marrow, disseminated intravascular coagulation, multiorgan failure and shock.
Treatment is symptomatic. There is no specific antidote for thioctic acid.
special instructions
Sick diabetes mellitus During treatment (and especially at the initial stage), it is necessary to monitor the concentration of glucose in the blood and, if necessary, adjust the dose of insulin or an oral hypoglycemic drug.
During treatment with Thiogamma you should not use alcoholic drinks, because ethanol reduces therapeutic effect thioctic acid, promotes the development and progression of neuropathy.
Each tablet contains 49 mg of lactose monohydrate, which corresponds to at least 0.0041 bread units.
Thioctic acid does not affect the ability to operate potentially dangerous machinery or drive a car.
Use during pregnancy and lactation
The drug is prohibited for use in pregnant and lactating women.
Use in childhood
According to the instructions, Tiogamma is contraindicated for children and adolescents under 18 years of age.
Drug interactions
- ethanol and its metabolites: the effect of thioctic acid is weakened;
- cisplatin: its effectiveness decreases;
- glucocorticosteroids: their anti-inflammatory effect is enhanced;
- insulin, oral hypoglycemic drugs: their effect is enhanced.
Thioctic acid binds metals (iron, magnesium), therefore, if simultaneous use of drugs containing them is necessary, at least 2-hour intervals between doses should be observed.
Thioctic acid reacts with sugar molecules [for example, with a solution of levulose (fructose)], resulting in the formation of sparingly soluble complexes.
In the form of an infusion solution, Thiogamma is incompatible with solutions that react with disulfide and SH groups, Ringer's solution and dextrose solution.
Analogs
Analogues of Thiogamma are the following drugs: Thioctacid BV, Lipoic acid, Thiolepta, Berlition 300, Thioctacid 600T.
Terms and conditions of storage
Store out of reach of children, protected from light, at temperatures up to 25 °C.
Shelf life – 5 years.
This page provides a list of all Thiogamma analogues by composition and indication for use. A list of cheap analogues, and you can also compare prices in pharmacies.
- Most cheap analogue Thiogamma:
- The most popular analogue of Tiogamma:
- ATX classification: Thioctic acid
- Active ingredients/composition: thioctic acid
Cheap analogues of Tiogamma
When calculating the cost cheap analogues of Tiogamma taken into account minimum price, which was found in price lists provided by pharmacies
Popular analogues of Tiogamma
The list of drug analogues based on statistics of the most requested medicines
All analogues of Tiogamma
Analogues in composition and indications for use
| Name | Price in Russia | Price in Ukraine |
|---|---|---|
| Alpha lipoic acid | -- | 7 UAH |
| -- | 272 UAH | |
| thioctic acid | 460 rub. | 66 UAH |
| thioctic acid | -- | 7 UAH |
| thioctic acid | 44 rub. | 7 UAH |
| thioctic acid | -- | 7 UAH |
| Alpha lipoic acid | 167 RUR | 240 UAH |
| 5 rub | 360 UAH | |
| thioctic acid | 755 RUR | 14 UAH |
| thioctic acid | -- | 7 UAH |
| thioctic acid | -- | -- |
| thioctic acid | -- | 7 UAH |
| thioctic acid | 75 RUR | 7 UAH |
| thioctic acid | 74 RUR | 700 UAH |
| thioctic acid | 75 RUR | -- |
| thioctic acid | 131 RUR | 246 UAH |
| thioctic acid | -- | -- |
| thioctic acid | -- | -- |
The above list of drug analogues, which indicates Thiogamma substitutes, are the most suitable because they have the same composition active ingredients and coincide in indications for use
Analogues by indication and method of use
| Name | Price in Russia | Price in Ukraine |
|---|---|---|
| -- | 230 UAH | |
| mumiyo | 20 rub | 7 UAH |
| Alder | 34 rub. | 6 UAH |
| human placenta extract | 1736 RUR | 71 UAH |
| Chamomile officinalis | 33 rub. | 7 UAH |
| Rowan | 43 RUR | -- |
| 27 rub. | -- | |
| -- | -- | |
| Rose hip | 30 rub | 7 UAH |
| Immortelle sandy, St. John's wort, Chamomile officinalis | -- | 4 UAH |
| bioglobin-y | -- | -- |
| Rowan, Rosehip | -- | -- |
| Argentum nitricum, Acidum arsenicosum, Pulsatilla pratensis, Stryсhnos nux-vomica, Carbo vegetabilis, Stibium sulfuratum nigrum | 203 RUR | 7 UAH |
| -- | 12 UAH | |
| dalargin | -- | -- |
| dalargin | -- | 133 UAH |
| combination of many active ingredients | -- | 17 UAH |
| Marshmallow, Blackberry, Peppermint, Plantain, Chamomile, Licorice, Common Thyme, Common Fennel, Hops | -- | -- |
| St. John's wort, Calendula officinalis, Peppermint, Chamomile, Common yarrow | 35 rub. | 6 UAH |
| Cinquefoil erecta | 150 rub. | 9 UAH |
| Kelp | -- | -- |
| lecithin | -- | 248 UAH |
| combination of many active ingredients | -- | 211 UAH |
| sea buckthorn | -- | 13 UAH |
| combination of many active ingredients | -- | -- |
| Rowan chokeberry | 68 RUR | 16 UAH |
| Valerian officinalis, Stinging nettle, Peppermint, Oats, Great plantain, Chamomile, Chicory, Rose hip | -- | -- |
| Hawthorn, Calendula officinalis, Flax, Peppermint, Great plantain, Chamomile, Yarrow, Hops | -- | -- |
| Calamus, peppermint, chamomile, licorice, fragrant dill | 36 rub. | 7 UAH |
| Common celandine | 26 rub. | 5 UAH |
| encad | -- | -- |
| -- | -- | |
| -- | 20 UAH | |
| Nitisinone | -- | 42907 UAH |
| miglustat | RUB 155,000 | 80100 UAH |
| sapropterin | RUB 34,453 | 35741 UAH |
| 57 RUR | 5 UAH | |
| 67 RUR | 7 UAH | |
| albumin black food grade | 2 rubles | 5 UAH |
| Calendula officinalis, Chamomile officinalis, Licorice glabra, Tripartite series, Salvia officinalis, Eucalyptus rodoformis | 48 RUR | 7 UAH |
| 485 RUR | 7 UAH | |
| 70 rub | -- | |
| extract donated blood | -- | 7 UAH |
| vitreous | 1700 rub. | 7 UAH |
| homeopathic potencies of various substances | 31 rub. | 7 UAH |
| -- | 20 UAH | |
| homeopathic potencies of various substances | 3600 rub. | 109 UAH |
| uridine triacetate | -- | -- |
| uridine triacetate | -- | -- |
Different composition, may have the same indication and method of use
| Name | Price in Russia | Price in Ukraine |
|---|---|---|
| Calamus, Elecampane, Leuzea safflower, Dandelion, Licorice, Rosehip, Echinacea purpurea | -- | 15 UAH |
| Actinidia, Artichoke, ascorbic acid, bromelains, Ginger, inulin, Cranberry | -- | 103 UAH |
| valine, isoleucine, leucine, lysine hydrochloride, methionine, threonine, tryptophan, phenylalanine, calcium pantothenate | -- | -- |
| -- | 7 UAH | |
| levocarnitine | 54 RUR | 335 UAH |
| levocarnitine | 1010 rub. | 635 UAH |
| levocarnitine | -- | 156 UAH |
| levocarnitine | -- | 7 UAH |
| levocarnitine | -- | 7 UAH |
| -- | 7 UAH | |
| levocarnitine | -- | 7 UAH |
| -- | -- | |
| -- | -- | |
| levocarnitine | 16 rub. | 570 UAH |
| ademetionine | -- | -- |
| ademetionine | 400 rub | 292 UAH |
| ademetionine | 63 RUR | 7 UAH |
| ademetionine | -- | 720 UAH |
| ademetionine | -- | 7 UAH |
| ademetionine | -- | 7 UAH |
| citrulline malate | 10 rub | 7 UAH |
| imiglucerase | RUB 67,000 | 56242 UAH |
| agalsidase alfa | RUB 148,000 | 86335 UAH |
| agalsidase beta | RUB 158,000 | 28053 UAH |
| laronidase | 29000 rub. | 289798 UAH |
| alglucosidase alpha | -- | -- |
| alglucosidase alpha | RUR 49,600 | -- |
| galsulfase | 75200 rub. | 64646 UAH |
| idursulfase | 131000 rub. | 115235 UAH |
| velaglucerase alfa | 142000 rub. | 81770 UAH |
| taliglucerase alpha | -- | -- |
To compile a list of cheap analogues of expensive drugs, we use prices that are provided to us by more than 10,000 pharmacies throughout Russia. The database of drugs and their analogues is updated daily, so the information provided on our website is always up to date as of the current day. If you have not found the analogue you are interested in, please use the search above and select the medicine you are interested in from the list. On the page of each of them you will find everything possible options analogues of the sought-after medicine, as well as prices and addresses of pharmacies where it is available.
How to find a cheap analogue of an expensive medicine?
To find inexpensive analogue medicine, generic or synonym, first of all we recommend paying attention to the composition, namely the same active ingredients and indications for use. The same active ingredients of a drug will indicate that the drug is a synonym for the drug, pharmaceutically equivalent or a pharmaceutical alternative. However, we should not forget about the inactive components of similar drugs, which may affect safety and effectiveness. Do not forget about the instructions of doctors; self-medication can harm your health, so before consuming any medical product Always consult your doctor.Thiogamma price
On the websites below you can find prices for Tiogamma and find out about availability at a pharmacy near youThiogamma instructions
INSTRUCTIONS
on the use of the drug
Thiogamma
pharmachologic effect
The active ingredient of Thiogamma (Tiogamma-Turbo) is thioctic (alpha-lipoic) acid. Thioctic acid is produced in the body and serves as a coenzyme for the energy metabolism of alpha-keto acids through oxidative decarboxylation. Thioctic acid leads to a decrease in glucose levels in the blood serum and promotes the accumulation of glycogen in hepatocytes. Metabolic disorders or a lack of thioctic acid are observed with excessive accumulation of certain metabolites in the body (for example, ketone bodies), as well as in case of intoxication. This leads to disruptions in the aerobic glycolysis chain. Thioctic acid is present in the body in two forms: reduced and oxidized. Both forms are physiologically active, providing antioxidant and antitoxic effects.
Thioctic acid regulates the metabolism of carbohydrates and fats, has a positive effect on cholesterol metabolism, and has a hepatoprotective effect, improving liver function. It has a beneficial effect on reparative processes in tissues and organs. Pharmacological properties thioctic acid is similar to the effects of B vitamins. During the initial passage through the liver, thioctic acid undergoes significant transformations. Significant individual variations are observed in the systemic availability of the drug.
When used internally, it is quickly and almost completely absorbed from the digestive system. Metabolism occurs with oxidation of the side chain of thioctic acid and its conjugation. The half-life of Thiogamma (Tiogamma-Turbo) is from 10 to 20 minutes. Eliminated in urine, with the predominant metabolites of thioctic acid.
Indications for use
For diabetic neuropathy to improve tissue sensitivity.
Mode of application
Thiogamma-Turbo, Thiogamma for parenteral administration
Thiogamma-Turbo (Tiogamma) is intended for parenteral administration by intravenous drip infusion. For adults, use a dose of 600 mg (contents of 1 bottle or 1 ampoule) 1 time per day. The infusion is carried out slowly, over 20-30 minutes. The course of therapy is approximately 2 to 4 weeks. In the future, internal use of Thiogamma tablets is recommended. Parenteral administration of Thiogamma-Turbo or Thiogamma for infusion is prescribed for severe sensory disturbances associated with diabetic polyneuropathy.
Rules for parenteral administration of Thiogamma-Turbo (Tiogamma)
The contents of 1 bottle of Thiogamma-Turbo or 1 ampoule of Thiogamma (600 mg of the drug) are dissolved in 50-250 ml of 0.9% sodium chloride solution. The rate of intravenous infusion is no more than 50 mg of thioctic acid per minute - this approximately corresponds to 1.7 ml of Thiogamma-Turbo solution (Tiogamma). The diluted drug should be used immediately after mixing with the solvent. During infusion, the solution must be protected from light with a special light-protective material.
Thiogamma
The tablets are intended for internal use. It is recommended to prescribe 600 mg of the drug once a day. The tablet should be swallowed whole, taken with or without food, with plenty of water. The duration of tablet therapy is from 1 to 4 months.
Side effects
Central nervous system: V in rare cases Immediately after using the drug as an infusion, convulsive muscle twitching is possible.
Sense organs: impaired sense of taste, diplopia.
Hematopoietic system: purpura (hemorrhagic rashes), thrombophlebitis.
Hypersensitivity reactions: Systemic reactions may cause anaphylactic shock; eczema or hives at the injection site.
Digestive system (for Thiogamma tablets): dyspeptic manifestations.
Others: if Thiogamma-Turbo (or Thiogamma for parenteral administration) is administered quickly, respiratory depression and a feeling of squeezing in the head are possible - these reactions stop after reducing the infusion rate. Also possible: hypoglycemia, hot flashes, dizziness, sweating, pain in the heart, decreased blood glucose levels, nausea, blurred vision, headache, vomiting, tachycardia.
Contraindications
Patient conditions that easily provoke the development of lactic acidosis (for Thiogamma-Turbo or Thiogamma for parenteral administration);
childhood;
period of pregnancy and lactation;
allergic reactions to thioctic acid or other components of Tiogamma (Tiogamma-Turbo);
severe hepatic or renal functions;
acute stage myocardial infarction;
decompensated course of respiratory or cardiovascular failure;
dehydration;
chronic alcoholism;
acute disorders cerebral circulation.
Pregnancy
During pregnancy or breastfeeding, the use of Thiogamma and Thiogamma-Turbo is not recommended, since there is no sufficient clinical experience prescription of drugs.
Drug interactions
The effectiveness of hypoglycemic drugs and insulin increases in combination with Tiogamma (Tiogamma-Turbo). Thiogamma-Turbo or Thiogamma solution is incompatible with a solvent containing glucose molecules, since thioctic acid forms sparingly soluble complex compounds with glucose. In in vitro experiments, thioctic acid reacted with ionic metal complexes. For example, a combination with cisplantin, magnesium, or iron can reduce the effect of the latter when combined with thioctic acid. Solvents that contain substances that interact with disulfide compounds or SH groups are not used to dilute the Thiogamma-Turbo (Tiogamma) solution (for example, Ringer's solution).
Overdose
In case of an overdose of Thiogamma (Tiogamma-Turbo), headache, vomiting and nausea are possible. Therapy is symptomatic.
Release form
Tiogamma-Turbo
Solution for parenteral infusion in 50 ml bottles (1.2% thioctic acid). Package – 1; 10 bottles. Special light-protective cases are included.
Thiogamma tablets
Tablets for internal use 600 mg each, coated. Pack of 30; 60 tablets.
Thiogamma solution for infusion
Solution for parenteral administration in ampoules of 20 ml (3% thioctic acid). The package contains 5 ampoules.
Storage conditions
In a place that is protected from light; at temperatures from 15 to 30 degrees Celsius. The solution prepared for intravenous infusion cannot be stored. Ampoules and vials must only be in their original packaging.
Compound
Tiogamma-Turbo
Active substance (in 50 ml): thioctic acid 600 mg.
50 ml of solution for infusion Thiogamma-Turbo contains meglumine salt of alpha-lipoic acid in the amount of 1167.7 mg, which corresponds to 600 mg of thioctic acid.
Thiogamma
Active substance (in 1 tablet): thioctic acid 600 mg.
Additional substances: colloidal silicon dioxide, microcrystalline cellulose, talc, lactose, methylhydroxypropyl cellulose.
Thiogamma
Active substance (in 20 ml): thioctic acid 600 mg.
Additional substances: water for injection, macrogol 300.
20 ml of solution for infusion Thiogamma contains meglumine salt of alpha-lipoic acid in the amount of 1167.7 mg, which corresponds to 600 mg of thioctic acid.
Pharmacological group
Hormones, their analogues and antihormonal drugs
Medicines based on pancreatic hormones and synthetic hypoglycemic drugs
Synthetic hypoglycemic agents
Active substance: Thioctic acid
Additionally
The bottle with dissolved Thiogamma-Turbo is covered with special light-protective cases that are included with the drug. Thiogamma solution is protected with light-protective materials. When treating patients, serum glucose levels should be regularly measured, according to which the dosage of insulin and hypoglycemic drugs should be adjusted to avoid hypoglycemia. The therapeutic activity of thioctic acid is significantly reduced when drinking alcohol (ethanol). Others important warnings No.
Analogues of the drug thiogamma are presented, in accordance with medical terminology, called “synonyms” - drugs that are interchangeable in their effects on the body, containing one or more identical active ingredients. When selecting synonyms, consider not only their cost, but also the country of production and the reputation of the manufacturer.
Description of the drug
Thiogamma- Metabolic drug. Thioctic (α-lipoic) acid is an endogenous antioxidant (binds free radicals), synthesized in the body during the oxidative decarboxylation of alpha-keto acids.As a coenzyme of mitochondrial multienzyme complexes, it participates in the oxidative decarboxylation of pyruvic acid and alpha-keto acids. Helps reduce blood glucose concentrations and increase glycogen content in the liver, as well as overcome insulin resistance.
Participates in the regulation of lipid and carbohydrate metabolism, affects cholesterol metabolism, improves liver function, has a detoxifying effect in case of salt poisoning heavy metals and for other intoxications. It has hepatoprotective, hypolipidemic, hypocholesterolemic and hypoglycemic effects. Improves trophism of neurons.
In diabetes mellitus, thioctic acid improves endoneurial blood flow, increases glutathione content to physiological significance, which ultimately leads to improvement functional state peripheral nerve fibers in diabetic polyneuropathy.
List of analogues
Note! The list contains synonyms of Thiogamma, which have a similar composition, so you can choose a replacement yourself, taking into account the form and dose of the medicine prescribed by your doctor. Give preference to manufacturers from the USA, Japan, Western Europe, as well as well-known companies from of Eastern Europe: KRKA, Gedeon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.
| Release form(by popularity) | price, rub. |
| Thiogamma | |
| R - r for infusion 12 mg / ml 50 ml fl N1. (Solyufarm GmbH and Co.KG (Germany) | 219.60 |
| R - r d / inf 12 mg / ml 50 ml vial No. 1 (Solyufarm GmbH and Co. KG (Germany) | 230.50 |
| Tab 600 mg N30 (Artesan Pharma GmbH and Co.KG (Germany) | 996.20 |
| 600 mg No. 30 tab p/o (Dragenopharm Apotheker Püschl Gmb (Germany) | 1014.10 |
| Solution for infusion 12mg/ml 50ml fl N1 (Solyufarm GmbH and Co.KG (Germany) | 2087.80 |
| Alpha lipoic acid | |
| ANTI - AGE 100 mg capsules, 30 pcs. | 293 |
| Alpha-lipoic acid | |
| Beplition | |
| Berlition 300 | |
| Ampoules 300 mg, 12 ml, 5 pcs. | 497 |
| Oral, tablets 300 mg, 30 pcs. | 742 |
| Berlition 600 | |
| Ampoules 600 mg, 24 ml, 5 pcs. | 776 |
| Lipamide | |
| Lipamide film-coated tablets, 0.025 g | |
| Lipoic acid | |
| Lipoic acid | |
| 30 mg No. 30 tab p/o Kvadrat - S (Kvadrat - S LLC (Russia) | 79 |
| Lipoic acid film-coated tablets | |
| Lipothioxone | |
| Neurolipon | |
| 300 mg No. 30 caps (Farmak OJSC (Ukraine) | 252.40 |
| Octolipen | |
| 300 mg caps N30 (Pharmstandard - Leksredstva OJSC (Russia) | 379.70 |
| 30mg/ml amp 10ml N10 (Pharmstandard - UfaVITA OJSC (Russia) | 455.50 |
| 30 mg / ml 10 ml No. 10 concentrate for the preparation of solution for infusion (Pharmstandard - Ufa Vit. z - d (Russia) | 462 |
| 600 mg No. 30 tab (Pharmstandard - Tomskkhimpharm OJSC (Russia) | 860.30 |
| Polity | |
| Thioctacid 600 | |
| Thioctacid 600 T | |
| Ampoules 600 mg, 24 ml, 5 pcs. | 1451 |
| Thioctacid BV | |
| Tablets 600 mg, 100 pcs. | 2928 |
| Thioctic acid | |
| Thioctic acid | |
| Thioctic acid-Vial | |
| Thiolepta | |
| Tab 300 mg N30 (Canonpharma production CJSC (Russia) | 393.60 |
| Tablet p/pl.o 600 mg N60 (Canonpharma Production CJSC (Russia) | 1440.10 |
| Thiolipon | |
| Film-coated tablets 300 mg, 30 pcs. | 300 |
| Ampoules 300 mg, 10 ml, 10 pcs. | 383 |
| Film-coated tablets 600 mg, 30 pcs. | 641 |
| Espa-lipon | |
| 600 mg No. 30 tab (Pharma Wernigerode GmbH (Germany) | 694.10 |
| 600 mg / 24 ml amp N1 (ESPARMA GmbH (Germany) | 855.40 |
| 600 mg / 24 ml amp N5 (ESPARMA GmbH (Germany) | 855.70 |
Reviews
Below are the results of surveys of site visitors about the drug thiogamma. They reflect personal feelings surveyed and cannot be used as an official recommendation for treatment with this drug. We strongly recommend that you contact a qualified medical specialist to select a personal course of treatment.Visitor survey results
Seven visitors reported effectiveness
Thirteen visitors reported cost estimates
| Participants | % | ||
|---|---|---|---|
| Dear | 11 | 84.6% | |
| Not expensive | 2 | 15.4% | |
28 visitors reported frequency of intake per day
How often should I take Thiogamma?Most respondents most often take this drug once a day. The report shows how often other survey participants take this drug.
| Participants | % | ||
|---|---|---|---|
| 1 per day | 22 | 78.6% | |
| 2 times a day | 5 | 17.9% | |
| 3 times a day | 1 | 3.6% | |
33 visitors reported dosage
| Participants | % | ||
|---|---|---|---|
| 501mg-1g | 15 | 45.5% | |
| 11-50mg | 6 | 18.2% | |
| 201-500mg | 5 | 15.2% | |
| 6-10mg | 3 | 9.1% | |
| 51-100mg | 2 | 6.1% | |
| 101-200mg | 1 | 3.0% | |
| 1-5mg | 1 | 3.0% | |
Five visitors reported a start date
How long does it take to take Thiogamma to feel an improvement in the patient’s condition?Survey participants in most cases felt an improvement in their condition after 1 month. But this may not correspond to the period after which you will begin to improve. Check with your doctor for how long you need to take this medicine. The table below shows the results of the survey on the initiation of effective action.
| Participants | % | ||
|---|---|---|---|
| 1 month | 2 | 40.0% | |
| > 3 months | 2 | 40.0% | |
| 1 day | 1 | 20.0% | |
Eight visitors reported appointment times
When is the best time to take Thiogamma: on empty stomach, before, after or during meals?Site users most often report that they take this medicine on an empty stomach. However, your doctor may recommend a different time for you. The report shows when the remaining patients surveyed take their medication.
123 visitors reported the patient's age
Visitor reviews
There are no reviews |
Official instructions for use
There are contraindications! Read the instructions before useThiogamma
THIOGAMMARegistration number
Tradename drug: Thiogamma ®
International nonproprietary name:
ThiogammaDosage forms: film-coated tablets; concentrate for the preparation of solution for infusion; solution for infusion. Composition of the drug
1 tablet, coated, contains:
active substance: Thiogamma - 600 mg;
Excipients: microcrystalline cellulose, lactose, talc, colloidal silicon dioxide, hypromellose, lactose monohydrate, sodium carboxylmethylcellulose, talc, simethicone, magnesium stearate, macrogol 600, sodium lauryl sulfate.
1 ampoule 20 ml concentrate for the preparation of solution for infusion contains:
active substance: megluminic salt of thioctic acid - 1167.7 mg (equivalent to 600 mg of thioctic acid);
Excipients: meglumine, macrogol 600, water for injection.
1 bottle 50 ml of solution for infusion contains:
active substance: megluminic salt of thioctic acid - 1167.7 mg (equivalent to 600 mg of thioctic acid);
Excipients: meglumine, macrogol 300, water for injection.
Description
Capsule-shaped tablets, light yellow in color with white inclusions, coated, scored on both sides of the tablet.
Transparent solution of yellowish-green color.
A transparent solution of light yellow or yellowish-green color.
Pharmacotherapeutic group. Metabolic agent. ATC code: 05BA
Pharmacological properties
Thiogamma ( alpha lipoic acid) - endogenous antioxidant (binds free radicals), in the body it is formed during the oxidative decarboxylation of alpha-ketoxylots. As a coenzyme of mitochondrial multienzyme complexes, it participates in the oxidative decarboxylation of pyruvic acid and alpha-keto acids. Helps reduce blood glucose concentrations and increase glycogen in the liver, as well as overcome insulin resistance. By the nature of its biochemical action it is close to B vitamins. Participates in the regulation of lipid and carbohydrate metabolism, stimulates cholesterol metabolism, and improves liver function. It has hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic effects. Improves trophism of neurons. The use of megluminic salt of thioctic acid in solutions for intravenous administration (which has a neutral reaction) can reduce the severity of adverse reactions.Pharmacokinetics
When taken orally, it is quickly and completely absorbed from the gastrointestinal tract (taken with food reduces absorption). The time to reach maximum concentration is 40-60 minutes. Bioavailability - 30%.Has a “first pass” effect through the liver. The formation of metabolites occurs as a result of side chain oxidation and conjugation.
Volume of distribution is about 450 ml/kg. Thiogamma and its metabolites are excreted by the kidneys (80-90%). The half-life is 20-50 minutes. Total plasma clearance is 10-15 ml/min.
When administered intravenously, the time to reach the maximum concentration is 10-11 minutes, the maximum concentration is 25-38 mcg/ml. The area under the concentration-time curve is about 5 μg h/ml.
Indications To application
Contraindications
Hypersensitivity to the components of the drug.Pregnancy period of breastfeeding.
Childhood(efficacy and safety of use have not been established).
Directions for use and doses
600 mg is prescribed orally once a day. The tablets are taken without chewing, with a small amount of liquid.The drug is also administered intravenously at a dose of 600 mg per day (1 ampoule of concentrate for preparing a solution for infusion 30 mg/ml or 1 bottle of solution for infusion 12 mg/ml). At the beginning of the course, the drug is administered intravenously for 2-4 weeks. Then you can continue taking the drug orally at a dose of 300-600 mg per day. The drug should be administered slowly, with no more than 50 mg of thioctic acid per minute (equivalent to 1.7 ml of concentrate for the preparation of a solution for infusion of 30 mg/ml).
Rules for preparing the solution
The content of 1 ampoule (equivalent to the content of thioctic acid 600 mg) is mixed with 50-250 ml of 0.9% sodium chloride solution and administered as an infusion over 20-30 minutes. Infusions are made from vials that are placed in the supplied hanging light-protective cases made of black polyethylene. When using a solution for infusion in bottles, Thiogamma® infusions are made directly from these bottles, which are placed in the accompanying hanging light-protective cases made of black polyethylene. Side effect
When taken orally, dyspepsia is possible, including nausea, vomiting,
After intravenous administration, convulsions are very rarely possible; diplopia; pinpoint hemorrhages in the mucous membranes and skin; thrombocytopenia, hemorrhagic rash (purpura), thrombophlebitis; with rapid administration, intracranial pressure may increase (a feeling of heaviness in the head); difficulty breathing. The listed side effects go away on their own.
Allergic reactions are possible: urticaria, systemic allergic reactions (up to the development of anaphylactic shock). Hypoglycemia may develop (due to improved glucose absorption).
Overdose
Symptoms: nausea, vomiting, headache. Treatment is symptomatic. There is no specific antidote. Interaction with others medicines In vitro, Thiogamma reacts with ionic metal complexes (for example, with cisplatin), therefore, when used simultaneously, Thiogamma O (solution for infusion) may reduce the effect of cisplatin. With sugar molecules, Thiogamma forms poorly soluble complex compounds. Therefore, thioctic acid infusion solution is incompatible with dextrose solution, Ringer's solution and with solutions that may react with compounds with SH groups or having disulfide bonds. When used simultaneously, Thiogamma O enhances the effect of insulin and oral hypoglycemic agents. Alcohol (ethanol) reduces the therapeutic activity of thioctic acid.special instructions
Patients taking the drug Thiogamma O should refrain from drinking alcohol. In patients with diabetes mellitus, constant monitoring of blood glucose concentrations is necessary, especially during initial stage therapy. In some cases, it is necessary to reduce the dose of insulin or oral hypoglycemic drug to avoid the development of hypoglycemia.Release form
Film-coated tablets, 600 mg. 10 tablets in blisters. 3, 6 or blisters along with instructions for use are placed in a cardboard box.Concentrate for the preparation of a solution for infusion 30 mg/ml in 20 ml dark glass ampoules. 5, 10 or 20 ampoules together with a hanging light-protective case made of black polyethylene and instructions for use are placed in a cardboard box.
Solution for infusion 12 mg/ml in dark glass bottles of 50 ml; 1 or 10 bottles together with hanging light-protective cases according to the number of bottles, made of black polyethylene and instructions for use are placed in a cardboard box.
Best before date
Film-coated tablets - 3 years.Concentrate for the preparation of solution for infusion 300 mg/10 ml and 600 mg/20 ml - 5 years.
Solution for infusion 600 mg/50 ml - 5 years.
Do not use after the expiration date indicated on the package.
Storage conditions
Film-coated tablets should be stored in a dry place at a temperature not exceeding 25°C.Concentrate for the preparation of solution for infusion 30 mg/ml in ampoules and solution for infusion 12 mg/ml in vials - in a place protected from light at a temperature not exceeding 25°C.
Vials and ampoules should be stored in their original packaging until direct use.
Keep out of the reach of children.
Vacation conditions
On prescription. Manufacturer Film-coated tabletsVerwag Pharma GmbH & Co. KG,
produced by Artesan Pharma GmbH and Co. KG, Germany.
Concentrate for the preparation of solution for infusion 30 mg/ml, solution for infusion 12 mg/ml Verwag Pharma GmbH and Co. KG,
produced by Solupharm GmbH and Co. KG, Germany. Culver Strasse 7, 71034 Boblingen.
Representative office in Moscow: 117587. Moscow, Varshavskoe highway, 125 Zh
The information on the page was verified by physician-therapist E.I. Vasilyeva.
