home Audience 3 How long can heparin ointment be used? Will heparin ointment help? Analogues of heparin ointment

How long can heparin ointment be used? Will heparin ointment help? Analogues of heparin ointment

Why and how is it used? It is this issue that today’s article will be devoted to.

General information

Heparin ointment is medical drug for external use. It belongs to the group of anticoagulants direct action. Doctors almost always prescribe this remedy to their patients if there is an urgent need for it. But often people themselves purchase such an ointment, since it is dispensed without a doctor’s prescription.

So, let's find out in what cases it is used this remedy, how it works, and what contraindications it has.

Composition of the drug

Before answering the question of what is used and how it is used in medical practice, you should find out its composition. The active ingredients of this drug are:

benzocaine;
sodium heparin;
benzyl nicotinate.

In addition, the product contains auxiliary components: glycerin, stearin, petroleum jelly, purified water, peach oil, etc.

Heparin ointment: indications for the drug

There are quite a few diseases that can be treated with a drug such as heparin ointment. What is this remedy used for? To answer the question, we decided to present to your attention a small list that includes the most common ailments for the prevention and treatment of which this particular medication is used (sometimes in combination with other drugs):

external or as well as inflammation hemorrhoids after childbirth;
trophic ulcers of the leg;
treatment and prevention of venous thrombosis and thrombophlebitis (most often arising from varicose veins veins);
post-infusion and post-injection phlebitis, as well as periphlebitis (that is, inflammation of the veins and surrounding tissues);
superficial mastitis;
inflammation of blood vessels (lymphatic);
various swelling, infiltrates and hematomas (subcutaneous);
injuries and bruises of subcutaneous or fatty tissue, joints, muscle tissue, tendons, etc.

Heparin ointment: for what and how is it used?

If necessary, the product is applied in a thin layer to the affected area and then gently rubbed into the skin. The course of treatment with ointment ranges from 3 to 7 days (use 2-4 times a day or more).

For varicose veins this drug It is recommended to apply to the skin very carefully. In this case, the product should not be actively rubbed into the affected areas, as this can easily lead to the spread of the inflammatory process throughout the vessel, as well as create a threat of rupture of existing blood clots.
For hemorrhoids (external), the ointment must be applied to a cotton pad and then applied to the inflamed nodes. If lumps have formed inside the anus, the drug should be administered using a special nozzle.
For injuries and bruises, it is advisable to apply this remedy not immediately, but only the next day. Otherwise, this may cause bleeding from damaged vessels.

Now you know what heparin ointment is, what it is used for and how to use it correctly. However, it is worth noting that the product is strictly prohibited from being applied to abrasions and open wounds, as well as on skin areas where there are pustules, pimples, etc.

To one of the famous medications for external use is heparin ointment, which received its name due to the heparin present in its composition, in clinical practice known as a direct anticoagulant.

The drug is produced by manufacturers in the form of a homogeneous ointment of a whitish color with a yellow tint, practically odorless, packaged in aluminum tubes.

Local use of the product is aimed at reducing tissue swelling and resolving blood clots - thrombi.

Heparin ointment is characterized by the following medicinal properties:

local anesthetic;
antithrombotic;
anti-inflammatory;
anticoagulant;
decongestant.

How does Heparin ointment work?

The therapeutic effect of topical application of the ointment is manifested due to its balanced composition.

The medication contains:

heparin is an acidic sulfur-containing glycosaminoglycan:
benzocaine local anesthetic:
benzyl nicotinate (benzyl ether nicotinic acid);
Excipients, creating the fatty base of pharmaceutical products (sunflower seed oil, glycerin (glycerol), white soft paraffin, stearic acid, emulsifier, etc.).

Released after application medicinal composition heparin neutralizes inflammatory processes, blocks the production of thrombin, providing an antithrombotic effect and stimulating the fibrinolytic properties of blood plasma, and prevents the random division of connective tissue cells.

Getting on the skin and mucous membranes, benzyl nicotinate in short time dilates superficial vessels, facilitating the penetration of heparin into damaged cells into tissues.

The third active component, benzocaine, exhibits an anesthetic effect, removing painful sensations. Painful reactions occur as a result of inflammation of the walls of blood vessels and an increase in pressure in them when the blood flow is blocked by a blood clot.

Heparin ointment: indications for use

According to the instructions, doctors prescribe medicine to patients with the following pathologies:

Thrombophlebitis of superficial veins (prevention and treatment) in patients prone to thrombosis.
External hemorrhoids.
External hemorrhoids, including their inflammation during the period after labor.
Trophic ulcers localized in the area of the feet and legs.
Swelling and subcutaneous infiltrates, including those formed after intramuscular injections.
Superficial mastitis.
Hematomas after bruises.
Injuries accompanied by ruptures of ligaments and soft tissues.
Tendon and joint injuries.
Diseases lymphatic system(elephantiasis, lymphangitis).

For varicose veins, the remedy is effective on early stages development pathological process when the veins are noticeably dilated lower limbs, the appearance of small vascular network on the epidermis and spider veins has just begun. The use of the product allows you to get rid of the feeling of heaviness in the legs, relieves hyperemia, swelling and burning of the skin, normalizes blood microcirculation in the skin, activates the processes of resorption of already formed blood clots and prevents the appearance of new ones.

Heparin ointment: contraindications

The ointment is not used if the patient has an allergic intolerance to the main or auxiliary substances.

Application of the product is contraindicated in the presence of ulcerative processes in the skin with tissue necrosis (ulcerative surfaces with necrosis of adjacent areas of the skin), as well as in case of any external damage.

With caution and under medical supervision, the drug is prescribed to patients with thrombocytopenia and a tendency to increased bleeding (blood clotting according to the coagulogram is significantly lower than normal).

During pregnancy, breastfeeding and in childhood The ointment can be used externally only as prescribed by the specialist observing you. The drug is not prescribed to children under 1 year of age.

Avoid getting the composition into your eyes. After applying the ointment, wash your hands thoroughly with soap to avoid accidentally touching the conjunctiva.

Heparin ointment: side effects

If there is an individual intolerance to any of the components, allergic reactions may develop: spots, rash, urticaria, hyperemia (redness) of the skin, itching, burning at the site of application, tissue swelling. If any of the above phenomena occur, you should immediately stop applying the ointment and contact your doctor to select another medicine.

Prolonged application of ointment over a large area of the body can lead to hemorrhagic complications. That is why any medications with heparin, including ointment, should be used according to the instructions and only as prescribed by a dermatologist, phlebologist, therapist, proctologist, or pediatrician.

How to use Heparin ointment correctly

The ointment is for external use only. For thrombophlebitis of the superficial veins, the product is applied to problem areas of the skin in a thin layer, 1 to 3 times a day, gently rubbing. One gram of cream is enough to treat an area of skin with a diameter of up to 5 cm. The course of therapy is determined by the doctor, depends on the characteristics of the disease and usually ranges from 3 days to 1 week.

Therapy for external hemorrhoids is carried out by applying ointment directly to painful areas, fixing the product with sterile dressing. Rectal administration of the drug is also used using tampons soaked in heparin ointment. Frequency of use – 2-3 times a day.

The course of treatment is carried out until the inflammatory phenomena completely disappear, from 3 days to 2 weeks. For hemorrhoids in pregnant women and after childbirth, the ointment can be used only after the approval of the attending physician.

Places of bruises, hematomas and bruises are lubricated with the composition 1-2 times a day until they disappear completely.

Resorption of subcutaneous infiltrates is carried out in the same way. Due to the anticoagulant effect, subcutaneous fluids dissolve blood clots, pain is relieved, and the condition of capillary vessels improves.

Heparin ointment: application in cosmetology

The medicinal properties of the drug are actively used by cosmetologists and women who have crossed the 35-year mark to reduce fine wrinkles, treat rosacea, acne and bags under the eyes.

The ointment is applied to the face in courses lasting from 7 to 10 days, after which a break is taken for 1 month. Before using the composition, the skin is cleansed with mild products.

Do not injure the skin with deep peeling and scrubs.

To enhance the effect, cleaned and dried skin is lubricated with a thin layer of almond or peach kernels oil, as well as oil squeezed out of the capsule fat-soluble vitamin E (tocopherol).

The ointment is applied to problem areas (area of fine wrinkles, for example, crow's feet in the corners of the eyes, bags under the eyes, areas with subcutaneous capillary patterns and spider veins), avoiding contact of the composition with the mucous membranes of the lips, nose and eyes.

The procedure is carried out twice a day - after morning washing and before bedtime. After application remedy It is gently rubbed in with patting movements until completely absorbed.

Important! Before using the facial product for the first time, a home test for allergies. To do this, a tiny amount of the product, the size of a match head, is applied to the skin behind the ear and the skin reaction is observed throughout the day. If there are no visible changes (itching, redness, rash), the ointment can be safely applied to all areas of the face.

The ingenuity of lovely ladies knows no bounds. To preserve youth and beauty, they are ready to tirelessly search for more and more new methods. And sometimes they discover incredible opportunities and solutions. These include non-standard use of drugs. This is how a new purpose for “grandmother’s remedy” appeared. Heparin ointment for wrinkles began to be used as an anti-aging agent at home. Will it bring the expected effect in the fight against age-related changes skin? How not to harm your face when using ointment? You will learn about this from the article.

Heparin ointment in cosmetology

Why not? Extremely cheap and accessible pharmaceutical drug has mass useful properties, It has natural composition. Traditionally, the drug was used in areas “below the waist.” Can heparin ointment be applied to the face? The affirmative answer is given by cosmetologists and many of those who have tried the effect of “heparin” on themselves. So, what does heparin help with?

Components of heparin ointment

In the annotation to medicinal drug Heparin ointment you will not find recommendations for the use of ointment in for cosmetic purposes. Its direct purpose is to reduce blood clotting to prevent blood clots. This is dealt with actively active substance– heparin. It is synthesized from the tissues of domestic animals: pigs or large cattle. The anesthesin contained in the composition provides an analgesic effect. Benzyl nicotinate dilates blood vessels, opening the way for the active substance.

Do not apply the ointment for more than 7 days in a row.

But fashionistas are interested in the excipients of the drug:

Peach oil is a source of vitamins and nourishes the skin.
Cosmetic stearin protects the skin from aggressive environment and bad weather.
Vaseline prevents skin flaking and dryness.
Glycerin moisturizes, softens and smoothes the dermis.
Nipagin is an antiseptic. Relieves swelling and inflammation.

The logic of using ointment in anti-wrinkle cosmetology immediately becomes clear: the auxiliary components cope well with dry skin, eliminating “crow’s feet” and age-related changes.

Together with active substance noted such useful cosmetic properties heparin ointment:

Heparin - anti-wrinkle remedy

Everything together (active and auxiliary substances) determines the mechanism of action pharmacological drug: the ability to have an anti-aging effect on the skin, eliminate swelling and bruises under the eyes. Agree, such properties of a drug for external use are in great demand in modern cosmetology.

Effect of ointment on the face

The use of the ointment was effective in the fight against skin rashes on the face, relieving swelling - the drug improved tissue metabolism by regulating blood flow. Those who applied heparin ointment for acne noticed that their facial skin became smoother, flaking disappeared, and small wrinkles in the skin smoothed out.

The active substance of the ointment penetrates deep into the tissue. Next, glycerin and peach oil enter the process, nourishing the dermis with vitamins and filling the cells with moisture. After several days of use, peeling of the dermis stops, dryness disappears, and complexion improves.

The therapeutic effect of the drug is noticeable when spider veins on the face - rosacea. Along with troxevasin, heparin ointment strengthens the capillary walls of blood vessels, improves blood flow, and removes vascular mesh.

Remember that rosacea cannot be cured with heparin alone; a complex effect on problem areas is necessary:

laser correction,
electrocoagulation.

The complex effect of the anticoagulant does not lead to a lifting effect comparable to the effect of specially selected cosmetics, which are very ruinous for family budget. This is the opinion of many cosmetologists and those who dared to experiment with ointment “for other purposes.”

At the same time, there are reviews from those who have achieved good results from using the ointment on their face. Quite possible, given the mechanism of action natural ingredients medicines. Tissue rejuvenation occurs due to improved blood flow in the epidermal cells. The result will become noticeable after 3-5 days of use. If you haven't noted positive result– give up the experiment: this rejuvenation method is clearly not for you.

Before starting the procedures, look at the reaction of the skin of your face - apply a drop of the product in the area behind the ear. There is no burning or redness - you can work with the drug on other areas of the face.

To obtain a rejuvenating effect, heparin ointment is applied in a thin layer to cleansed facial skin twice a day. The procedure is performed within a week.

Do not apply the medicine in a thick layer, according to the principle, the more the better. Heavy fatty base (vaseline) can clog pores and cause acne!

Does ointment help with wrinkles around the eyes?

Use this over-the-counter drug with caution when caring for the delicate skin around the eyes - the anticoagulant has a powerful effect on the skin. Before opening the tube, you need to deal with the problems of this area of the face.

Heparin ointment is indicated for bruises and bruises that can occur from “beauty injections” around the eyes.
For swelling of the face caused by impaired lymphatic drainage. The components “deliver” oxygen to the cells.
When there is an excess of interstitial fluid, it regulates metabolism at the cellular level.
For expression wrinkles – “ crow's feet"in the corners of the eyes. Active and auxiliary substances cause the synthesis of collagen and elastin.

But before using the drug on delicate areas of the face, remember its main purpose. An anticoagulant is used to improve blood flow and prevent blood clots on the body below the waist. The sensitive dermis around the eyes may not withstand the “aggressive” intervention of strong ingredients.

It is doubly bad if the drug gets on the mucous membrane of the eye. This is directly stated in the annotation for the medicine. Therefore, “measure seven times” before using heparin ointment for other purposes.

Contraindications to the use of heparin ointment on the face

Those who have passed the sensitivity test and are ready to experiment with their face should carefully consider the contraindications and possible side effects of using heparin ointment “in sensitive areas.” Remember: ointment is a medicine, not a harmless cosmetic cream.

Contraindications for use:

Mechanical violations of the integrity of the skin: wounds, opened ulcers
Tendency to bleed.
Hemophilia.
Sensitivity of the skin.
Acne.
Allergic reactions.
Pregnancy.

The ointment base (Vaseline) may be comedogenic, meaning it can clog pores in a small number of people. As cosmetologists note, petroleum jelly and mineral oil rarely cause such a reaction. However, if you notice the appearance of black specks on your face, stop applying the ointment.

The same warning applies to carriers of rosacea. Uncontrolled use medicine may lead to vascular fragility. And this is a big problem that requires serious and long-term treatment.

Common side effects of the drug include:

facial hyperemia,
the occurrence of dermatitis.

For a review of the use of heparin ointment for wrinkles on the face and swelling under the eyes, see here:

Now that you know the composition and mechanism of action of heparin ointment, you can independently decide on the advisability of using it as an anti-inflammatory agent. age remedy for face. Ointment is not a panacea, and in some cases even an enemy to facial beauty. You can try this method, but do not forget that in your arsenal cosmetics There are less aggressive anti-aging creams. Facial care should be safe, comfortable and effective.

You will be able to find Additional information on this topic in the section.

Heparin ointment - combination drug, a direct anticoagulant intended for external use.

The ointment looks like a homogeneous jelly-like mass white with a yellowish tint, odorless. The main active ingredient is heparin, which is gradually released from the ointment when local application, has an antithrombotic effect and reduces inflammation.

On this page you will find all the information about Heparin ointment: full instructions on application to this medicine, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Heparin ointment. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Direct acting anticoagulant.

Conditions for dispensing from pharmacies

Dispensed without a doctor's prescription.

Prices

How much does Heparin ointment cost? The average price in pharmacies is 100 rubles.

Release form and composition

Ointment for external use. Tubes 25 g. The basis of Heparin ointment is:

sodium heparin, which blocks blood clotting and blood clot formation - 2500 IU per tube volume;
benzocaine - an anesthetic that interferes with the transmission of nerve impulses - 1 g;
benzyl nicotinate - stimulates blood flow, has an irritating and warming effect - 20 mg.

Additionally, the medication contains: glycerin, petroleum jelly, purified water, corn and/or sunflower oil, emulsifiers, etc., depending on the technology of a particular manufacturer.

Pharmacological effect

The active components of the drug have the following effects:

Benzyl nicotinate promotes the dilation of superficial blood vessels, helping the rapid absorption of heparin into the blood.
Benzocaine is a powerful anesthetic local action, behind a short time eliminating pain symptoms.
Heparin , being released from the ointment after applying it to the affected area, it stops inflammatory process and promotes the resorption of blood clots. This substance reduces the amount of fibrin in the blood, a protein that forms the basis of a blood clot. As a result, the ability of cells to stick to each other is significantly reduced. Heparin is not able to dissolve the blood clot itself, but it stops the process of its further increase and the blood clot gradually resolves.

The simultaneous action of the three main components determines the effectiveness of the drug, providing quick fix severe symptoms.

Indications for use

What does it help with? Indications for use or when Heparin ointment is prescribed:

during the treatment of dislocations and other traumatic injuries joints;
for swelling caused by extensive injuries;
- a disease manifested by dilation of hemorrhoidal veins and their blockage;
for - diseases of the veins caused by the formation of blood clots blocking blood flow;
with its complications - the disease manifests itself in a pathological increase in the diameter of the vein, thinning of its wall and the formation of nodes similar to local aneurysms of similar extensions;
in the treatment of extensive hematomas, both muscle and tendon;
for the treatment of inflammation of the veins.

When prescribing the dosage of a medicine, the doctor always takes into account the general condition of the patient, so it is always individual.

Contraindications

Heparin ointment for bruises is used only topically, and is applied only to intact areas of the skin. Do not apply the drug to open, purulent or bleeding wounds, necrotic ulcers.

Since the effect of Heparin ointment is based on the suppression of thrombus formation, it is unacceptable to use it in case of impaired blood clotting processes and increased bleeding, with a low level of platelets in the blood, as well as with hypersensitivity to the components of the drug.

Use during pregnancy and lactation

Can it be used during pregnancy and breastfeeding? The effect of Heparin ointment on the body during pregnancy and lactation has not been fully studied. It is known that the components of the drug do not have a systemic effect, except for heparin, which does not penetrate into breast milk or placental circulation.

Instructions for use

The instructions for use indicate that Heparin ointment is applied to the affected areas two or three times a day (0.5-1 g per area with a diameter of 3-5 cm), gently rubbing into the skin. The course of treatment usually lasts until the inflammatory processes disappear, usually 3-7 days.

Heparin ointment for hemorrhoids is applied to rectal swabs or bandages (usually made of calico fabric), which are then inserted into the anus or applied to hemorrhoids, respectively (the bandages must be fixed after application).

Heparin ointment is used for hemorrhoids every day, and the course of treatment lasts until the painful symptoms disappear - usually no more than 3-14 days.

Side effects

Overdose

There is virtually no danger of overdose, since active ingredients are contained in a small volume, and when absorbed, a small amount of them enters the blood.

special instructions

Heparin ointment has no effect on performance nervous system and does not inhibit the speed of psychomotor reactions, therefore it can be used without fear to treat vehicle drivers or workers operating complex mechanisms.

Given medicine It is prescribed with special caution to patients with blood clotting disorders. During the therapy period, the patient's blood counts and general condition are monitored.

Drug interactions

Do not prescribe topically simultaneously with tetracyclines and antihistamines.

In this medical article you can familiarize yourself with the drug Heparin ointment. Instructions for use will explain in what cases it is prescribed, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the forms of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Heparin ointment, from which you can find out whether the medicine helped in the treatment of thrombophlebitis, hemorrhoids, varicose veins in adults and children, for which it is also prescribed. The instructions list analogues of Heparin ointment, prices of the drug in pharmacies, as well as its use during pregnancy.

A local drug with a pronounced antithrombotic effect is Heparin ointment. Instructions for use prescribe the use of the medicine for bruises, hemorrhoids, and varicose veins.

Release form and composition

Heparin ointment is available in aluminum tubes of 10 or 25 g in cardboard packs. It is a thick, homogeneous, white substance without any noticeable odor or impurities.

The composition of Heparin ointment includes:

100 IU/g heparin;
40 mg/g benzocaine (local anesthetic);
0.8 mg/g benzyl nicotinate.

Excipients: soft paracin, white, glycerin, stearic acid, sunflower oil, purified water.

pharmachologic effect

When applied to the skin, the ointment prevents the formation of blood clots and has an anti-inflammatory and local anesthetic effect.

Heparin, which is gradually released from the ointment, reduces the inflammatory process and has an antithrombotic effect, benzyl nicotinate (benzyl ester of nicotinic acid) dilates superficial vessels, thereby promoting the absorption of heparin, benzocaine anesthetizes.

What does Heparin ointment help with?

Indications for use of the drug include:

Infiltrates and swelling as a result rapid administration medications into the buttock muscle.
Lymphangitis.
Subcutaneous hematomas.
Inflammation of a vein after an unsuccessful injection or drip infusion of drugs.
Prolapse of hemorrhoids, accompanied by an inflammatory process.
Superficial mastitis in women.
Soft tissue bruises, accompanied by severe local hyperthermia and swelling.
Thrombophlebitis.

What else is Heparin ointment used for? The medication is effective for hemorrhoids, superficial thrombophlebitis, periphlebitis, mastitis, elephantiasis, phlebitis, lymphangitis - used both for the prevention and treatment of diseases.

Good reviews of Heparin ointment, used to relieve swelling, treat bruises, injuries (including tendons, joints, muscle tissue), localized infiltrates, ulcers on the extremities, used as a healing agent after repeated intravenous injections. Heparin ointment for bruises is often used, because... it promotes the resorption of subcutaneous hematomas.

Instructions for use

Apply externally. The instructions for use of Heparin Ointment require applying a thin layer to the affected area (at the rate of 0.5-1 g (2-4 cm) per area with a diameter of 3-5 cm) and gently rub into the skin. The ointment is used 2-3 times a day every day until the inflammation disappears, on average from 3 to 7 days. The possibility of a longer course of treatment is determined by the doctor.

In case of thrombosis of external hemorrhoids, the ointment is applied to a calico or linen pad, which is applied directly to the thrombosed nodes and fixed.

The ointment should be used daily until the symptoms disappear, on average from 3 to 14 days; for the same purpose, you can use a soaked tampon, which is inserted into the anus.

Contraindications

Heparin ointment for bruises is used only topically, and is applied only to intact areas of the skin. Do not apply the drug to open, purulent or bleeding wounds, necrotic ulcers.

Since the effect of the medication is based on suppressing thrombus formation, it is unacceptable to use it for:

heparin-induced thrombocytopenia (HIT) type II (on this moment or history);
hypersensitivity to the components of Heparin ointment, which can cause side effects;
with a low level of platelets in the blood, as well as with increased sensitivity to the components of the drug;
presence of damage skin(ulcers, open infected wounds, necrotic processes, etc.);
thrombocytopenia;
violation of blood clotting processes and increased bleeding;
hypocoagulation.

Side effects

When using ointments, it is possible side effects as allergic reactions and skin hyperemia. However, in general, the drug is easily tolerated and works effectively.

Children, pregnancy and breastfeeding

Heparin ointment during pregnancy is used in the most difficult cases- for blockage and inflammation of the veins, for external hemorrhoids, for injuries that are accompanied by hematomas, including after IVs and infusions.

Before prescribing, a woman should check her individual reaction to the drug - to do this, the ointment is applied to the forearm area, after which she needs to observe the reaction for some time. If there is redness or swelling, other medications may be worth considering.

In pediatrics, it is used to treat children older than 12 months. The drug is applied to the affected area in a thin layer and rubbed into the skin with light movements. A single dose for a child depends on the area of the lesion and ranges from 0.5 to 3 cm of the product.

special instructions

When using Heparin ointment simultaneously with non-steroidal anti-inflammatory drugs, the patient increases the risk of bleeding or other disorders of the blood coagulation system.

Drug interactions

The anticoagulant effect of heparin is enhanced by the simultaneous use of the drug with antiplatelet agents, anticoagulants and NSAIDs. The effect of heparin is reduced by using the drug with thyrotoxin, ergot alkaloids, antihistamines, Tetracycline and nicotine.

Heparin should not be administered topically in combination with NSAIDs, H1-histamine receptor blockers, or tetracyclines.

Analogues

Heparin ointment has similar analogs in action:

Conditions of release and storage

Heparin ointment is available in pharmacies without a doctor's prescription. The drug should be stored out of the reach of children, avoiding direct contact with the tube. sun rays. The maximum temperature for storing ointment should not exceed 25 degrees.

The shelf life of the drug is 2 years, after which the ointment must be disposed of.

Price

The average cost of Heparin ointment in Moscow pharmacies is 55 - 76 rubles. In Kyiv you can buy medicine for 50 hryvnia, in Kazakhstan - for 480 tenge. In Minsk, pharmacies offer the drug for 1.88 - 2 bel. ruble