What helps "Nifedipine". Instructions for use of tablets. Reliable assistant in the treatment of cardiovascular pathologies Nifedipine: what is prescribed and how to take the medicine correctly

In this article, we will consider the instructions for the use of Nifedipine: at what pressure this drug is prescribed, how effective it is and what contraindications it has. This remedy is one of the most prominent representatives of antihypertensive drugs. It blocks the calcium tubules, due to which the musculature of the vessels relaxes, contributing to a decrease in pressure to normal indicators V short time. This drug has a number of various benefits and can be used to treat chronic processes and relief of emergency conditions.

"Nifedipine" is in great demand among hypertensive patients, in connection with which there is often a shortage of it in pharmacies. In such cases, the drug can be replaced similar medicines. Today, analogues of "Nifedipine" have an identical pharmacological effects and used in the treatment similar diseases. Next, we will look at what this medicinal product there are substitutes, and we will find out what advantages and disadvantages they have. But first, let's study the instructions for using the medication.

The composition of the drug and its form of release

"Nifedipine" is a drug from the category of drugs for vascular and cardiotherapy. Release it in tablets. There are 2 types of them: short and prolonged effects on the body. The former are used to normalize pressure or in the presence of pain in chest. Extended-release tablets are prescribed to patients who have hypertension that is in the compensation stage.

Main active substance The drug is a derivative of dihydropyridine. This component is able to relax the muscles of the vascular system in the shortest possible time, expand the arteries and increase blood flow, which helps to reduce heart rate and reduce pressure. So, judging by the instructions for the use of Nifedipine, at what pressure this remedy is prescribed, there is no need to think. This is a drug for hypertensive patients.

The therapeutic effect occurs, as a rule, already 20 minutes after ingestion. More than 90% of the active ingredient is absorbed through the intestines, which makes it possible to reduce the load on the stomach and gallbladder facilitating the work of the kidneys and liver.

How the drug works

The mechanism of action of "Nifedipine" is that the drug blocks the activity of slow calcium channels of cell membranes. Calcium ions enter in smaller quantities into the arteries of the heart, muscles, and also peripheral vessels. As a result:

• blood circulation in the heart is activated;
• the lumen of the coronary and arterial vessels increases;
• increased blood flow in the kidneys;
• pressure decreases;
• decreased vascular resistance to blood flow in the periphery.

Like other drugs in the form of tablets, Nifedipine also contains excipients, which are magnesium, sodium, potato and wheat starch, as well as microcrystalline cellulose, along with titanium dioxide, hypromelose and macrogol. The shell of the tablets is made of gelatin and talc.

Most of the above substances increase the impact of the main component on the body, which provides a high healing effect. If a long course is necessary, a prolonged form is prescribed, and to combat acute attacks angina pectoris and hypertension prescribe short-acting tablets that do not have a shell.

When to use the remedy

What are the indications for Nifedipine? It is prescribed in the following cases:

• If the patient has angina pectoris.
• At arterial hypertension as monotherapy or in combination with other antihypertensive drugs.

Please note that for the use of Nifedipine, the indications must be strictly observed.

How should the medication be taken

It is unacceptable to prescribe a remedy on your own. Its reception should be carried out under control medical specialist who is obliged to familiarize himself in detail with the condition of his patient and analyzes of his biological material, and in addition, with the results of the electrocardiogram. Great importance when choosing the dosage and duration of the treatment course, the age of the patient plays.

Maximum daily dose the main active ingredient should not exceed 40 mg. It is better to take it with meals, and you should choose liquid, but at the same time light meals. You can not drink this medicine with natural juices or sparkling water, as they contain aggressive ingredients that can dissolve the tablet shell before it enters the intestines.

The course of therapy with Nifedipine is usually at least 60 days. The initial dose for any indication for the use of this drug is 10 milligrams twice a day. According to the results therapeutic effect the doctor corrects the one-time and daily intake increasing or decreasing the dosage until the desired effect is achieved. IN severe cases it can reach 80 mg.

There are contraindications for taking Nifedipine. The tool is prohibited:

• with acute myocardial infarction;
• severe forms heart failure;
• arterial hypotension;
• the presence of unstable angina;
• cardiogenic shock;
• tachycardia;
• constriction mitral valve;
• bradycardia.

Manifestation of side effects of the drug

With an increase in the dosage of Nifedipine, side effects are not excluded. They may appear as follows:

1. From the side of the cardiovascular system - tachycardia, decreased pressure, chest pain, fainting, angina pectoris.
2. From the side nervous system- dizziness, difficulty swallowing, fatigue, drowsiness, headaches, depression.

Duration of reception, as a rule, is determined individually. Abrupt withdrawal of the drug is not practiced, as this can cause unwanted side effects. adverse reactions in the form of increased heart rate, pressure surges and malfunctions of the intestines. There are also likely to be malfunctions in the work of the hematopoietic organs.

Nifedipine analogues and their trade names

As already noted, there are only 2 types of Nifedipine tablets: short and prolonged exposure. Analogues of the drug, which are short-acting, include Fenigidin, Nicardia, Procardia, Kordaflex and Farmadipin.

Substitutes for prolonged action are such drugs as "Corinfar Uno" along with "Kordipin-retard", "Calcigard retard" and "Nifekard".

Immediately before choosing one or another Nifedipine analogue, it is necessary to justify the purposes for which the drug will be used and determine what effect should be obtained after using the drug. For example, in therapy hypertension it is best to use analogues with prolonged exposure. And to eliminate the hypertensive crisis, the choice of a short-acting analogue is recommended.

Among other things, before buying a drug, you should carefully study the attached instructions. But a doctor should prescribe it, since in case of non-compliance with the recommendations, the state of health and the progression of pathological processes may worsen.

Advantages and disadvantages

Consider the main advantages of Nifedipine analogues, as well as their disadvantages. If there is a need to replace "Nefedipin", it is necessary to take into account the pros and cons of the proposed funds:

• Some analogues of Nefedipine can have a local effect on the body, that is, they affect only the heart.
• Reduce risks negative impact on the development of the fetus (if used during pregnancy).
• When breastfeeding, there is no need to interrupt the lactation period.

The disadvantages of substitutes include the following disadvantages:

• A parallel intake of several drugs at once is required instead of one to replace the effect of Nefedipine.
• Carrying out substitution therapy can cost the patient more than the cost of one Nifedipine.

Which analogue should be preferred

Absolutely all substitutes for "Nefedipin" are high-quality products and have the same properties as it. In this regard, the patient can opt for less expensive medicine, however, it will be necessary to take into account the mechanism of action and the dosage of the agent.

IN medical practice There are many examples when the same active ingredient in medicines from different pharmacological manufacturers had different effects. But with Nifedipine, the situation is different. Almost twenty years have passed since the release of this drug, and all its analogues do not differ from the original. In this regard, when purchasing a medication, you can save money by choosing a less expensive substitute. According to the medicinal properties, the analogue of "Nifedipine" of prolonged action will be similar to the original.

I must say that it is extremely unlikely to purchase a fake drug in a pharmacy, which will contain chalk instead of the active ingredient, because Nifedipine is inexpensive means, and the named replacement will definitely not bring significant benefits. In addition, an experienced hypertensive patient can easily identify a fake, since he knows what therapeutic effect the drug should have and will not buy it next time.

Review of the most popular substitutes for "Nefedipin": "Corinfar"

Before replacement this drug for a drug similar in effect, it is imperative to consult a doctor to select the optimal dosage and identify contraindications to the use of the medication. Next, consider the analogues of "Nifedipine" in action: "Corinfar", "Cordaflex" and "Corinfar Uno".

The first substitute for "Nifedipine" is produced in the form of tablets. It has a prolonged action, and it is prescribed for the treatment of diseases of the heart and blood vessels:

• if the patient has arterial hypertension;
• against the background of ischemia of the myocardium;
• in the presence of angina pectoris.

Treatment with Corinfar is easily tolerated by patients, without side effects. In this case, the analogue of "Nifedipine" should be taken only on the recommendation of a specialist and under his supervision.

It is important to know that after a sharp cessation of taking Corinfar, hypertensive patients may develop a withdrawal syndrome, which will be expressed in an increase blood pressure, and in addition, in insufficient blood supply to the myocardium.

The drug "Cordaflex"

This is another analogue of Nifedipine, which belongs to the category of antihypertensive drugs. This substitute is quite common among people who have been suffering from hypertension for many years. The drug relieves spasms coronary arteries, relaxing the vascular walls and reducing myocardial oxygen demand. I must say that Kordaflex does not cause arrhythmias. This drug is prescribed in the following cases:

• If the patient has arterial hypertension at different stages.
• Against the background of ischemic heart disease.
• With a hypertensive crisis.
• In the presence of stable angina pectoris.

"Corinfar Uno"

This is the most popular analogue of Nifedipine tablets, since a single dose of this drug can provide a constant concentration of the active ingredient in the bloodstream for a whole day. Thanks to this tool, the productivity of treatment increases, the frequency of various complications, A internal organs are not subjected to additional loads. Thanks to this, these tablets are used in great demand among a certain category of patients.

Reception of substitutes for prolonged exposure requires compliance strict rules. The listed analogues of "Nifedipine" are forbidden to grind or dissolve under the tongue. Tablets must be taken in an unchanged state with a sufficient amount of liquid. You can not share a single dosage of the drug if the instructions for this possibility are not indicated.

Analogues in the treatment of hemorrhoids

The drug "Nifedipine" is endowed with many medicinal properties. So, it is also used to eliminate the symptoms of hemorrhoids. The named medication in this case can be replaced by the drug "Relief". This analogue promotes the healing of cracks, eliminating tissue swelling and restoring damaged vessels. As part of the treatment of hemorrhoids, you can use any suitable analogue gel "Nifedipine".

It is possible to make healing drug and independently at home. To do this, you need to prepare the necessary components, namely, Levomekol ointment, Nifedipine, Lidocaine and Cardiket tablets are taken. The method of preparation of the analog of "Nifedipine" is as follows:

• One tablet of Kardiket and eight pills of Nifedipine are crushed to a powdery state.
• 30 g of Levomekol and 5 g of Lidocaine are added to the powder.
• Then everything is thoroughly mixed and the resulting mixture is used as an ointment. It is applied in a thin layer to problem areas.

This ointment is applied once a day, but in some situations it can be applied twice a day. In fact, "Nifedipine" is produced in the form of a large number structural analogues, and each of these substitutes has its own name. But absolutely all of them contain the same active ingredient and have a similar therapeutic effect.

Comparative characteristics of Kapoten and Nifedipine

Some patients are trying to determine, for example, which is better - Kapoten or Nifedipine. There is no unambiguous opinion about which of these drugs is better for combating hypertension. Only the attending physician can decide what exactly should be taken by a particular patient to reduce pressure. Therefore, everything is purely individual. Sometimes it is enough to regularly take only Kapoten tablets in order to improve the condition and forget about the increase in pressure. But for some, "Capoten" for contraindications or for some other reason known to the doctor may not be suitable, and "Nifedipin", in turn, will effectively replace it.

By the way, Kapoten should never be used by people suffering from an increased heart rate, which exceeds 85 beats per minute. But at the same time, it must be emphasized that Kapoten is classified as the most harmless medicine. This analogue has a milder effect on the patient's body than Nifedipine, and practically does not have any side effects.

But Nifedipine has one definite advantage, which is that this drug is much cheaper than Kapoten. While about 300 rubles will have to be paid for Kapoten, Nifedipine costs patients three times cheaper.

Andipan or Nifedipine

"Andipan" is combination drug, giving vasodilating, analgesic, antispasmodic and sedative effects. It is prescribed for pain associated with spasm of peripheral arteries, cerebral vessels, smooth muscles of the stomach and intestines. And also in the presence of arterial hypertension. They have similar contraindications and side effects.

Extensive. The drug belongs to the group of drugs that block calcium channels, which have pronounced antihypertensive properties.

But the medicine not only reduces pressure, it has an anti-ischemic effect. What is the medicine Nifedipine, what are these tablets prescribed for and in what dosages, this article will tell.

Nifedipine not only reduces, but also protects the myocardium from lack of oxygen, as well as overloads that occur with high peripheral vascular resistance. The drug reduces the stretching of the heart muscle, enhancing its metabolic processes.

The drug Nifedipine indications for use has the following:

• hypertension syndrome;
• chronic heart failure;
• angiospathic circulatory disorders of the brain;
• ischemia;
• bradycardia and angina pectoris;
• vasospasm inner ear and retinas.

Long-acting nifedipine in combination with bronchodilators is prescribed as maintenance therapy for bronchial asthma and Raynaud's disease.

Efficacy in hypertension

The hypotensive effect of Nifedepine is expressed in slowing down the movement of calcium through the membrane of the smooth muscle cells of the arteries.

Calcium ions spasm the vessels and increase their contraction, and the drug blocks their flow.

It provides an expansion of the lumen of the coronary and peripheral branches of the arterial network, while there is a decrease in the resistance of the walls of blood vessels and a decrease in the load on the heart. The drug is well absorbed into the digestive tract, thus its action begins in the first ten minutes after consumption, which is especially important in hypertensive crisis.

Composition and forms of the drug

international generic name drug Nifedipine (INN) - Nifedipine.

Nifedipine is available in various dosage forms:

1. coated tablets. They contain 10 mg of nifedipine and the tablets long-acting- 20 mg. Excipients: corn starch - 58.25 mg, polysorbate - 2 mg, lactose monohydrate - 36.2 mg, hypromellose - 2.4 mg, microcrystalline cellulose - 51 mg, magnesium stearate - 150 mcg. The film shell contains: talc, hypromellose - 4.2 mg, macrogol - 1.4 mg, titanium dioxide - 1 mg, red oxide - 200 mcg;
2. capsules of 5 mg and 10 mg;
3. solution for infusion. The volume of vials is 50 ml. One milliliter in 1 ml contains 0.0001 g of nifedipine;
4. solution for intracoronary administration is available in 2 ml syringes, in 1 ml - 0.0001 g of nifedipine.

The use of the drug and dose

The recommended dose of the drug is 20 mg twice a day. If desired effect was not achieved, it is increased to 40 mg twice a day. Maximum rate- 80 mg. For liver problems, it should not exceed 40 mg.

Tablets Nifedipine 10 mg

Rules for the use of Nifedipine:

• the tablet is taken half an hour before breakfast at the same time;
• the medicine is washed down only with clean water;
• Do not chew or divide long-acting tablets.

You cannot stop taking Nifedipine on your own, if you want to reduce the dose of the drug, the doctor should adjust the treatment regimen.

From pressure Nifedipine can be taken regardless of the meal. It will enter the blood more slowly, but its effectiveness will not decrease.

The use of the drug requires compliance with certain rules:

1. the drug is used only under the supervision of a doctor. Carefully take the medicine for diabetic disease, severe forms of cerebral circulation disorders, problems with the kidneys and liver, hypovolemia;
2. during treatment with Nifedipine, alcohol should be completely abandoned. At the beginning of treatment, it is not recommended to drive;
3. it is necessary to consider with which drugs the drug can be combined, and with which it is not worth it. Nifedipine with tricyclic antidepressants, diuretics, nitrates, pressure-reducing agents enhances the hypotensive effect. The combined use of the drug with beta-blockers can contribute to the development of heart failure. Joint use with cimetidine increases the concentration of the drug in the blood. Rifampicin accelerates the metabolism of nifedipine, which reduces its effectiveness.

Short-acting tablets are drunk three times, those that are excreted in 12 hours are consumed twice a day, prolonged-acting tablets are taken once. It is advisable to administer the drug intravenously only in a hospital.

The intake of the drug depends on its half-life.

Contraindications

With collapse, cardiogenic shock, tachycardia, aortic stenosis, acute stage heart attack, severe heart failure, sensitivity to the components of the drug. Children and patients under 18 years of age this medicine are not assigned.

The drug may cause side effects:

1. from the digestive organs: diarrhea, heartburn, nausea, disruption of the liver. At long-term use prescription drug high doses possible manifestation of dyspeptic symptoms, the development of intrahepatic cholestasis;
2. from the hematopoietic organs: thrombocytopenia, leukopenia;
3. from the side of the heart and blood vessels: redness skin, a feeling of heat, the appearance of edema, a sharp decrease in pressure, tachycardia, angina pectoris, bradycardia;
4. from the side urinary organs : increased urine output, impaired kidney function;
5. from the side of the central nervous system: headaches, sleep disturbances, visual disturbances, tremor of the extremities;
6. from the side endocrine system: gynecomastia;
7. from the side of the skin: rash.

If the dose exceeded 120 mg of the drug, a 10% solution of calcium gluconate or calcium chloride is administered intravenously.

With an intravenous infusion of the drug, a burning sensation may appear at the injection site. With intracoronary administration of the drug in the first minutes, pressure may drop and the heart rate may increase.

To improve the tolerability of the drug and eliminate it side effects, it is necessary to take Nifedipine in combination with beta-blockers. Edema that occurs against the background of taking the medication quickly disappears after its withdrawal.

With an overdose, headaches appear, blood pressure drops sharply, the face swells, bradycardia occurs, and the pulse in the peripheral arteries disappears.

In severe cases, collapse develops, the patient loses consciousness, functions sinus node are significantly oppressed. If these symptoms are detected, the patient is washed with a stomach and activated charcoal is prescribed.

Analogues

The appearance on the pharmaceutical market of analogues of Nifedipine is associated with its popularity.

Medicine analogues:

• Adalat;
• Cordylin;
• Calciguard retard;
• Kordafen.

Most of the analogues are not inferior to Nifedepine in terms of effectiveness. The doctor will determine which drug the patient needs: short-acting or extended-acting.

Rapid-acting drug is not indicated for long-term treatment arterial hypertension and heart disease, it will be very useful in hypertensive crisis.

Before choosing a medicine, you should carefully study the instructions, consult a doctor about possible side effects.

Related videos

The video will tell you what Nifedipine tablets are for, at what pressure to take and when they are contraindicated:

Nifedipine is a drug whose main therapeutic effect is aimed at the treatment of hypertension. When it is taken, the coronary and peripheral arteries expand, the resistance of peripheral vessels decreases, and calcium entry into the smooth muscle cells of the vessels slows down. Nifedipine also found application in treatment of CHF, ischemia, angina and bradycardia.

The drug does not affect myocardial conduction and heart rate. TO side effects include the appearance of a rash on the skin, tachycardia, impaired renal function. Rapid-acting tablets are prescribed to relieve a hypertensive crisis, and prolonged Nifedipine is used for long-term therapy. Available more information about pressure pills Nifedipine in the RLS - Register of Medicines of Russia.

Nifedipine - medicinal product, active use which began in the 1970s. His advent advanced medicine to new level- so, the treatment of the most common cardiovascular disease became more efficient.

For many years, pharmacologists around the world have tested and improved the drug, reducing the risk of side effects and increasing the effectiveness of its use. Currently, Nifedipine is one of the priority medicines used in cardiology.

Dosage forms of the drug

Until the 2000s, Nifedipine was actively used in tablets and fast-acting capsules. The effect of them occurs within 20 minutes after taking the drug, but acts within 2-4 hours.

During this time, the drug instantly lowers blood pressure, causing a reflex release of adrenaline and related hormones, which, in turn, instantly reduce the concentration of Nifedipine in the blood and remove it from the body. Simultaneously with taking the drug in patients in the rare cases tachycardia is observed headache and a feeling of heat, which means that fast-acting nifedipine can cause an even greater pressure jump.

The problem of "immediate and dangerous effect" was solved by German pharmacologists who managed to develop a new prolonged form of the drug, the effect of which begins 40-50 minutes after administration and lasts 20-25 hours.

Compared with fast-acting nifedipine, the prolonged form has several advantages. Therefore, let's talk about everything in order.

"Long-playing" Nifedipine

In the long-term treatment of cardiovascular diseases and arterial hypertension, long-acting nifedipine is prescribed to patients. It is this dosage form provides a slow and measured intake of the component into the human blood, contributes to a smooth decrease in blood pressure, reduces the risk of atherosclerosis, tachycardia, headache and periodic "jumps" in the well-being of the treated person.

Compared to other cardiac drugs, long-acting nifedipine has fewer contraindications and side effects, and, therefore, is applicable to the majority of the population in need of quality treatment.

Useful properties of Nifedipine

Held clinical trials the drug made it possible to evaluate the significance of its use in the treatment of arterial hypertension, coronary heart disease, angina pectoris. It is noteworthy that Nifedipine has a pronounced antianginal effect, which is characteristic of beta-blockers and nitrates, and does not have excessive side effects on the body. In other words, Nifedipine is allowed to be used when similar cardiac drugs are contraindicated.

The effectiveness of the prolonged form is not affected by the amount of food consumed, which, of course, has a positive effect on the rating of the drug.

to the most common and effective forms the drug should include Osmo-Adalat and Corinfar, which allow you to maintain the required level of concentration medicinal substances in the blood during the day. The stability of the drug prevents the progression of arterial hypertension, and also promotes the healing of affected target organs (heart, kidneys, liver, etc.).

Despite the presence of the drug's only significant drawback - it is not used in the relief of hypertensive crises, long-acting nifedipine can not only improve the patient's condition, but also ensure the complete recovery of his cardiovascular system.

A little about the disadvantages of the drug Nifedipine

The use of a long-acting drug is not advisable for emergency reduction blood pressure during a patient's attack.

It is intended only to systematically maintain a stable state. circulatory system organism. First aid during hypertension will be provided by the "fast form" of Nifedipine. However, it has a number of disadvantages:

1. Frequent use. To prolong the effect of the drug, patients have to apply it several times a day. Irregular use of the drug reduces its effectiveness.
2. Status instability. The patient's well-being can constantly change, because. meals cause a weakening of the clinical action of Nifedipine.
3. unpredictable effect. Like any other medicine, fast-acting nifedipine affects the bodies of patients in different ways. genetic features, affected kidneys or the age of the patient can reduce or completely neutralize the effect of the drug.
4. Wave pressure. The specific properties of the drug cause constant fluctuations in blood pressure. From too high to too low and vice versa. In this regard, the body is constantly swelling and weakening. blood vessels which, in turn, provokes the formation of atherosclerosis.

The drug is prescribed only for the relief of hypertensive crises.

Dosage of Nifedipine

Long-acting tablets are prescribed 1-2 times a day. It is worth noting that the tablets should not be divided to reduce the dose of the component (unless the doctor has given the appropriate instructions), dissolve or dissolve. The drug is taken orally, with big amount water.

According to the instructions for Nifedipine, the course of admission should not exceed 14 days. Exceptions are only individual cases, agreed with the doctor.

Nifedipine: indications for use

Nifedipine is prescribed for the following diseases:

• Angina pectoris;
• Hypertrophic cardiomyopathy;
• Broncho-obstructive syndrome;
• Raynaud's syndrome;
• Pulmonary hypertension.

If your diagnosis is included in the specified list, do not rush to the pharmacy. First you should visit the cardiologist's office and consult about the advisability of using the medication. Self-medication can lead to terrible consequences, because Nifedipine has a number of contraindications.

Contraindications

The drug is not allowed to be used in cardiogenic shock, acute period of myocardial infarction, namely: in the first eight days, diagnosed arterial hypotension, tachycardia, bradycardia, mitral valve stenosis, sick sinus syndrome.

Nifedipine is also contraindicated in patients with renal / hepatic insufficiency; at inflammatory diseases bowel and Crohn's disease.

Nifedipine during pregnancy is strictly contraindicated. Exceptions can be made only in individual cases, agreed with the doctor and passing under his special supervision.

Unfortunately, many pages of the "Internet Web" are filled with false information about the need for expectant mothers to take the drug. Under no circumstances should you follow this council and self-medicate. It is also forbidden to take Nifedipine while breastfeeding the baby.

Side effects

Like any other drug, Nifedipine has different organisms different impact. In some cases, the body greedily absorbs the medication and does not give out its presence, in some cases, on the contrary, it tries with all its might to report the presence of a foreign substance. And that's where the side effects come in.

The most common reaction for older people after the first dose of Nifedipine is reddening of the hands and swelling of the joints of the arms and legs. A similar effect disappears at the end of 8 hours after taking the medicine.

The cardiovascular system can also "panic" and cause tachycardia, flushing of the face, a rapid decrease in blood pressure (up to fainting), anemia (rarely).

Concerning gastrointestinal tract, then there may be constipation, diarrhea, nausea.

Taking the drug in rare cases has a specific effect on the nervous system and sensory organs, causing dizziness, weakness in the limbs, headache and hearing loss.

In addition to the above, Nifedipine can cause tremor for the entire duration of the drug.

It is important to note that these side effects are not a guaranteed result from the use of the drug, but a warning about possible failure in organism.

"Nifedipine" is a drug widely used to treat patients with hypertension. It will help lower blood pressure in a relatively short time. It is also worth saying that when buying any type of Nifedipine preparation, you do not need a prescription, it is available in pharmacies for free sale.

Therapeutic action

What is the effectiveness of the drug? What properties does it have, are there any analogues of Nifedipine, what results do they give in treatment? This drug:

• Improves blood supply to the coronary arteries.
• Helps reduce peripheral resistance in blood vessels.
• Slightly reduces the myocardium.
• Reduces pressure.
• It is also a kind of blocker that does not allow calcium to enter the cells of the vascular muscles and has positive action with ischemia.

Release form

The drug "Nifedipine" is produced in the form of tablets, dragees, capsules, drops intended for oral administration.

The effectiveness and safety of taking it largely depends on which form of medication you have chosen. Since the beginning of the 70s of the last century, fast-acting Nifedipine tablets or capsules have been mainly used, and about 20 years ago, a prolonged form appeared in pharmacies. The drug, which in a short time lowers blood pressure, is also quickly excreted from the body. It has a rather low efficiency and tolerability is also not very good, when compared with those forms that act slowly and more effectively on the body during the day.

The fast-acting drug "Nifedipine" (the price for it is much lower - within 25-30 rubles per pack) in most cases helps a lot, especially when a person sudden jump pressure. It will help to reduce it in the shortest possible time, although this effect may not last long.

The effect of the drug depends on how much its concentration fluctuates in the blood, and how quickly it rises and falls. regular pills sharply lower blood pressure, the answer to this circumstance is a reflex and other stimulant hormones. All of these hormones can cause a person to have headaches, fever, and even redness on the skin.

You also need to remember that when taking a fast-acting drug that is excreted from the body in a short time, a “rebound” symptom may occur. This means that after a short time, the pressure may jump even higher than it was before you took the pill. Therefore, although the price for prolonged Nifedipine is slightly higher - from 40 to 50 rubles per package (50 tablets), its effect on the body is softer and longer. Almost no harm to the human condition.

Tablets "Nifedipine" from what?

This medicine is prescribed for hypertension, coronary disease, which is accompanied by an attack of angina pectoris. In combination with a drug such as Verapamil, it is prescribed to patients who have kidney problems, or rather, to slow the development of kidney failure. With its help, complex treatment heart failure, and together with drugs that dilate the bronchi, it is used in the treatment of asthma.

Each drug has no exception and the drug "Nifedipine".

Side effects

For whatever purpose the doctor prescribes you to take such a drug, be prepared for the fact that it can also cause side effects, such as:

• Violation of the kidneys.
• Sleep and vision disturbance.
• Muscle pain.
• Skin rash.
• Heartburn and nausea.
• peripheral edema.

If the side effect persists, then it is worth consulting with your doctor, you may need to reduce the dosage or have to stop the drug.

The use of the medicinal product

In order to achieve positive results in treatment, you need to know how to take Nifedipine tablets correctly. The application is quite simple and does not require special knowledge and skills from you.

Take it for 1-2 months 3-4 times a day, 100 mg. With a hypertensive crisis, it is worth taking it as a sleepy. To do this, take one tablet and put it under your tongue. To make the resorption of the drug go even faster, you can bite the pill. During this procedure, the patient must be in a supine position.

After half an hour, the medication can be repeated, in some cases the number of tablets can be increased to 3 pieces.

The pharmacy also sells Nifedipine prolonged tablets. Instructions for their use gives detailed diagram reception, while noting that they give the desired effect only when long-term use.

If you need to bring the patient out of a hypertensive crisis, then use "Nifedipine" in solution, it must be administered within 4-8 hours.

Tablets "Nifedipine" from what else is used, for what diseases are they considered effective? Raynaud's phenomenon is one such disease.

The drug "Nifedipine" with Raynaud's phenomenon

Raynaud's phenomenon is considered one of the most "beautiful" diseases of the cardiovascular system. It strikes upper limbs and gives out a whole color scheme. It is the hands that this disease affects most often. Behind all this "beauty" lies a huge number of complications associated to a greater extent with microcirculation disorders at the ends of the fingers and numerous changes in the mysteries of this disease due to the fact that the causes of its occurrence are still not known, and no doctor can give 100 % guarantee that the patient really has this disease.

Assumptions of the occurrence of the Raynaud phenomenon

Until now, the causes of the occurrence of this disease, but some of them still managed to be identified. Every person, especially winter period, supercooled, this is one of the reasons for the further development of the disease. Also frequent stressful situations may influence the development of the disease. Chronic finger injuries can also affect, especially for those who work in the construction industry.

All these factors lead to Raynaud's phenomenon. And what symptoms should indicate a person to the disease:

1. Spasms of the vessels of the hand.
2. Edema and blue discoloration of terminal phalanges.
3. Tendency to ulcers and panaritiums.
4. necrotic events.

Also, very often a sign of the disease can be constant chilliness of the fingers and very severe pain when cooling.

There are two ways to treat the disease: the first of them is Nifedipine tablets or analogues of Nifedipine, and the second method is a surgical intervention in which the patient is cut through the nerve fibers that conduct impulses.

As for drug treatment, not only Nifedipine analogues, but the drug itself showed excellent results in treatment.

Can this medicine be used during pregnancy?

Many women are interested in whether Nifedipine can be taken during pregnancy? Reviews of doctors and expectant mothers showed that it can be taken only in extreme cases and under the supervision of a physician.

Although studies on pregnant women have not been conducted, animal experiments have shown that taking Nifedipine can lead to perinatal asphyxia, premature birth and intrauterine retention

Although it is impossible to say for sure whether the drug causes such consequences, or whether some diseases of the mother lead to similar pathologies. But after careful study in pregnant women after taking this drug, similar symptoms were noted. Therefore, it is best not to take Nifedipine during pregnancy. Reviews about the drug are not confirmed laboratory research, and it is best not to risk the health of the mother and fetus.

I would also like to say that for children under 18 years old, the Nifedipine remedy is categorically contraindicated.

What can replace the drug "Nifedipine"?

Each patient often faced such a problem as the lack of the right medicine in a pharmacy. This often happens with the drug "Nifedipine". This is a very popular medicine, and it may not be available in pharmacies, but there are analogues of Nifedipine » . Among their huge number, you can choose the one that may suit your body even better.

If you are prescribed the Nifedipine emulsion, but the pharmacy does not have it, you can choose similar drug from this list:

• "Adalat".
• Kordafen.
• "Cordaflex".
• "Corinfar".
• "Kordipin".
• "Nicardia".
• "Procardia".
• "Pharmadipin".
• "Fenigidin".

All these drugs are available in tablets or capsules, except for "Farmadipin" - it is in drops. There are also prolonged analogues of Nifedipine:

• "Adalat-SL".
• "Corinfar Uno".
• "Corinfar-retard".
• "Kordipin-retard".
• "Nifebene-retard".
• "Nifedipine SS".

As can be seen from the lists above, the synonyms for this drug a large number of, and this is due to its popularity. Majority pharmaceutical companies are engaged in the production of an analogue of the drug "Nifedipine". Reviews of patients indicate that most of them are in no way inferior to him in terms of effectiveness.

Before choosing correct analogue, you need to clearly indicate for yourself for what purposes and what kind of drug you need, short-acting or extended.

Thus, a fast-acting drug is not recommended for long-term treatment. hypertension and diseases of the cardiovascular system. In these cases, it is better to stop the choice on a prolonged-acting drug, but in a hypertensive crisis, a quick-acting drug will become useful to you.

Before choosing an analogue or the main drug for yourself, carefully study the instructions for the drug "Nifedipine", indications and contraindications, so as not to harm your health with an incorrectly selected medicine.

But be also prepared for the fact that in a pharmacy a pharmacist can ask you a question: do you need the drug "Nifedipine" - gel or tablets? It is better to consult a doctor about this in advance.

"Nifedipine" (gel): indications

An emulsion or, as it is often called, a gel is a drug for the treatment of cracks in the anus, hemorrhoids in the early stages.

The composition of this drug includes lidocaine, nifedipine and isosorbite dinitrate, it is produced in tubes of 40 g.

Thanks to nifedipine, which is part of the gel, there is a relaxation of smooth muscle tissue and a rapid expansion of peripheral vessels. This substance in the composition of the emulsion relaxes the muscles of the anus, lowers rectal pressure.

Lidocaine, on the other hand, relieves pain syndrome, and isosorbitol dinitrate also helps to dilate blood vessels by penetrating into smooth muscle cells. It is thanks to such a properly selected composition that Nifedipine (gel) helps in the healing of fissures, removes fallen hemorrhoid nodes, relieves pain and stops bleeding.

The instructions for the drug indicate that the pain after the start of the use of the drug will disappear after a couple of days, after 14 days all the cracks in the anus area are tightened, and a month later there is a complete recovery, subject to the regular use of the Nifedipine gel. Reviews of patients about the drug are only positive. Most of them point out that a short time got rid of the pain and bleeding that tormented them.

The Israeli manufacturer of the Nifedipine emulsion claims that the drug has no side effects and contraindications, since its effect extends only to inflamed areas in the tissues and their healing. You can even prescribe the gel to pregnant women and those who are breastfeeding.

It is highly recommended to combine treatment with Nifedipine with a diet. The diet should contain dishes rich in fibers, a sufficient amount of liquid. Do not eat anything spicy or salty. If possible, do at least 10 minutes a day of physical therapy.

You can store an open package of Nifedipine gel for only two weeks, so you will need 2 packages to complete the entire course of treatment.

Summing up

In conclusion of our article, I would like to summarize and repeat the most important points. So, gel and tablets "Nifedipine" from what help?

The main role "Nifedipine" and its analogues play in the treatment of hypertension in patients with complications such as diabetes and metabolic syndrome. That is why similar drug and its analogues do not disrupt metabolism, to put it simply, do not affect blood sugar, cholesterol and triglycerides. But still, it is better to give preference to a daily drug in the form of GITS for patients with diabetes and high risk of cardiovascular disease.

"Nifedipine" of daily action will help not only to reduce the level of blood pressure in hypertension, but also protect all internal organs. Organoprotective qualities of the drug "Nifedipine":

• Reduces remodeling of the left ventricle of the heart.
• Optimizes blood circulation in all tissues of the human body.
• Positive effect on kidney function.
• Significantly improves functional state retinas of the eye.

In the treatment of hypertension, the drug "Nifedipine" is combined with almost all groups that are currently in great demand among doctors and patients:

• diuretics (diuretics);
• beta blockers;
• ACE inhibitors;
• angiotensin receptor blockers.

If you use the drug "Nifedipine" in combination with drugs from other groups, then you can significantly increase the effectiveness of treatment, reduce the dosage of tablets and reduce their unwanted side effects.

"Nifedipine" is a drug that helps with a hypertensive crisis and in general with hypertension. If the doctor makes an appointment and selects a few more drugs for him, then in this case you can be sure of the effectiveness of the treatment. Never self-medicate, so as not to harm the body and not aggravate the course of the disease.

Also "Nifedipine" (gel) can help in the treatment anal fissures and hemorrhoids, the results from its use are only positive.

Any drug has its contraindications. Be sure to read the instructions before starting treatment, even if the drug has no contraindications, no one will give you 100% guarantees that you will not have your own problems. discomfort from its application. There were cases that one tablet of "Nifedipine" quickly lowered the pressure, but at the same time a severe headache appeared. Always keep an eye on your health and take only those drugs prescribed by your doctor after completing a complete

Nifedipine - has antianginal and antihypertensive effects.

It relaxes vascular smooth muscles (relieves spasm), dilates coronary and peripheral (mainly arterial) vessels, lowers blood pressure and peripheral vascular resistance, and reduces afterload. Possessing the action of a cardioprotector, it reduces the need for oxygen in the heart muscle. Increases coronary blood flow.

Nifedipine effectively reduces pressure, and also helps to relieve muscle spasms. Without affecting the heart rhythm, it significantly lowers blood pressure. After taking Nifedipine begins to act after 20 minutes. (chewing accelerates the effect) and lasts up to 12 hours.

Clinical and pharmacological group

Calcium channel blocker.

Terms of dispensing from pharmacies

Released by prescription.

Prices

How much does Nifedipine cost in pharmacies? The average price is at the level of 45 rubles.

Release form and composition

Coated tablets, yellow color, with a biconvex surface; two layers are visible in cross section.

• active ingredient: nifedipine; 1 tablet contains nifedipine - 10 mg or 20 mg;
• excipients: milk sugar, potato starch, microcrystalline cellulose, povidone 25, sodium lauryl sulfate, magnesium stearate, hypromelose, tween 80, titanium dioxide E 171, macrogol 6000, talc, quinoline yellow E 104.

Pharmacological effect

Selective calcium channel blocker, dihydropyridine derivative. It inhibits the entry of calcium into cardiomyocytes and vascular smooth muscle cells.

It has antianginal and antihypertensive effects. Reduces the tone of vascular smooth muscle. Expands the coronary and peripheral arteries, reduces total peripheral vascular resistance, blood pressure and slightly - myocardial contractility, reduces afterload and myocardial oxygen demand. Improves coronary blood flow. Does not inhibit myocardial conduction. At long-term use nifedipine can prevent the formation of new atherosclerotic plaques in the coronary vessels.

At the beginning of treatment with nifedipine, there may be a transient reflex tachycardia and an increase in cardiac output that does not compensate for the vasodilation caused by the drug. Nifedipine enhances the excretion of sodium and water from the body. In Raynaud's syndrome, the drug can prevent or reduce vasospasm of the extremities.

Indications for use

According to the instructions for use, Nifedipine is used to treat high blood pressure. When used, it quickly stops. hypertensive crisis. Nifedipine may be recommended for:

• stagnant cardiopulmonary insufficiency;
• any degree;
• voltage;
• spasm of the coronary arteries;
• hypertrophic cardiomyopathy.

Excellent reviews have the drug Nifedipine from cardiologists, therapists. In accordance with the instructions, its use is effective in diagnosing:

• heart failure;
• stagnation of blood;
• pulmonary hypertension;
• disorders of cerebral circulation;
• hypertensive crisis;
• blockage of blood vessels;
• ischemic heart disease;
• atherosclerosis of peripheral arteries;
• bronchospasms.

Contraindications

Absolute (the use of the drug is strictly contraindicated):

1. Tachycardia;
2. Period 4 weeks after acute infarction myocardium;
3. Age up to 18 years;
4. Pregnancy;
5. Lactation;
6. Cardiogenic shock, collapse;
7. Sick sinus syndrome;
8. Decompensated heart failure;
9. Severe aortic/mitral stenosis;
10. Arterial hypotension with systolic blood pressure below 90 mm Hg;
11. Idiopathic hypertrophic subaortic stenosis;
12. Hypersensitivity to the drug or other derivatives of dihydropyridine.

Relative (the drug should be used with caution due to the risk of complications):

1. Chronic heart failure;
2. Diabetes;
3. Severe disorders of cerebral circulation;
4. Severe violations of kidney / liver function;
5. Malignant arterial hypertension.

Caution requires the use of the drug by patients on hemodialysis.

Use during pregnancy and lactation

During lactation and pregnancy Nifedipine in any form is not recommended.

In gynecological practice, in some cases, it is practiced to prescribe the drug during pregnancy as an antihypertensive agent, when other drugs are ineffective. It is also noted that Nifedipine during pregnancy helps to reduce the tone of the uterus, however wide use By this indication I have not received the drug yet.

Dosage and method of application

The instructions for use indicate that the dosage regimen of Nifedipine is set individually, depending on the severity of the disease and the patient's response to therapy. It is recommended to take the drug during or after a meal with a small amount of water.

• Initial dose: 1 tablet (10 mg) 2-3 times / day. If necessary, the dose of the drug can be increased to 2 tablets (20 mg) - 1-2 times / day.
• The maximum daily dose is 40 mg.

In elderly patients or patients receiving combined (antanginal or antihypertensive) therapy, as well as in violation of liver function, in patients with severe cerebrovascular accident, the dose should be reduced.

Side effects

Like other pressure pills, Nifedipine causes side reactions in the body:

1. On the part of hematopoiesis: leukopenia and thrombocytopenia;
2. On the part of the endocrine system - a manifestation of gynecomastia;
3. From the side genitourinary system: increased diuresis, against the background of long-term use - failure of the kidneys;
4. From the side of the central and peripheral nervous system: headaches, with prolonged use, muscle pain, sleep problems, tremors and visual disturbances;
5. From the side of the cardiovascular system: swelling of the skin and extremities, a strong drop in pressure, a feeling of warmth, asystole, tachycardia, bradycardia, angina pectoris;
6. From the gastrointestinal tract: diarrhea, nausea, heartburn and liver failure. If you take the drug for a long time large doses, this will affect the liver in the form of cholestasis or an increase in transaminases.

Overdose

When exceeding the recommended therapeutic dose Nifedipine tablets develop facial hyperemia, headache, bradycardia (decreased heart rate), a pronounced decrease in blood pressure. Overdose treatment consists in washing the stomach, intestines, taking intestinal sorbents (activated charcoal).

In the conditions of a medical hospital, therapy is carried out aimed at stabilizing the indicators of the functional activity of the cardiovascular system, as well as the introduction of an antidote, which is calcium chloride or calcium gluconate. With a significant decrease in the level of systemic arterial pressure, dopamine is used.

special instructions

Cancellation of the drug is carried out gradually (the risk of developing a withdrawal syndrome).

During the period of treatment, it is necessary to refrain from engaging in potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions, and from the use of ethanol.

drug interaction

When using the drug, it is necessary to take into account the interaction with other drugs:

1. In combination with nitrates, tachycardia increases and hypotensive action nifedipine.
2. Nifedipine reduces the concentration of quinidine in plasma. Increases the concentration of digoxin and theophylline in blood plasma, and therefore the clinical effect and / or the content of digoxin and theophylline in blood plasma should be monitored.
3. The simultaneous appointment of beta-blockers should be carried out under conditions of careful medical supervision, since this may cause an overly pronounced decrease in blood pressure, and in some cases, worsening the symptoms of heart failure.
4. The severity of the decrease in blood pressure increases with the simultaneous appointment of nifedipine with other antihypertensive drugs, cimetidine, ranitidine, diuretics and tricyclic antidepressants.
5. Rifampicin weakens the action of nifedipine (accelerates the metabolism of the latter by inducing the activity of liver enzymes).