home Audience 6 Antifungal cream "Clotrimazole": instructions for use. What does Clotrimazole help with? Instructions for use

Antifungal cream "Clotrimazole": instructions for use. What does Clotrimazole help with? Instructions for use

Clotrimazole instructions

Instructions Clotrimazole gives Full description the drug Clotrimazole, presenting it as an antifungal drug for external use.

Clotrimazole release form

The drug Clotrimazole has several forms of release. On pharmacy shelves it can be found in the form of ointments, creams, suppositories and solutions.

Clotrimazole composition

Clotrimazole ointment composition

Ointment for external use. Represents a mass white homogeneous consistency.

The active ingredient is clotrimazole. Excipients in required proportions propylene glycol, polyethylene oxide 1500, polyethylene oxide 400, nipagin or methylparaben.

Clotrimazole cream composition

Cream for external use. It is a homogeneous mass of white color.

The active ingredient is clotrimazole. Excipients in the required proportions: benzyl alcohol, cetostearyl alcohol, octyldodecanol, polysorbate, sorbitan stearate, synthetic spermaceti, as well as water.

Clotrimazole suppositories composition

The drug is in the form of vaginal suppositories having a cylindrical-conical shape. The color is white or with a yellow tint.

The active ingredient is clotrimazole. Excipients in the required proportions of semi-synthetic glyceride.

Clotrimazole solution composition

The drug has a soft emulsion-type consistency. White color.

The active ingredient is clotrimazole. Excipients in the required proportions: liquid paraffin, ketosteryl alcohol, white soft paraffin, ketomacrogol 1000, purified water, chlorocresol, disodium edetate, citric acid, sodium phosphate dibasic, propylene glycol, sodium metabisulfite.

Storage conditions

The drug should not be frozen. Can be stored for three years from the date of manufacture. The storage room must be inaccessible to children with an air temperature not exceeding 25 degrees.

Pharmacology

The drug Clotrimazole is an antifungal agent that has wide range actions. Apply topically. The effectiveness of its antifungal action is based on the ability to disrupt the synthesis of ergosterol, which is part of the fungal cell membrane.

The activity of Clotrimazole applies to dermatophytes, yeast-like and mold fungi, as well as to the causative agent of pityriasis versicolor (Pityriasis versicolor) and the causative agent of erythrasma. Clotrimazole is capable of providing antimicrobial action in relation to gram-positive (Staphylococcus, Streptococcus) and gram-negative bacteria (Bacteroides, Gardnerella vaginalis), as well as in relation to vaginal Trichomonas.

Indications for use Clotrimazole

Clotrimazole indications for use (ointment)

Clotrimazole ointment is indicated for external use in the following cases:

For fungal skin diseases;
For mycoses of the foot or skin folds;
With pityriasis versicolor;
With erythrasma;
For superficial candidiasis that is caused by dermatophyte, yeast (Candida), mold and other fungus or pathogen that is sensitive to clotrimazole;
For mycoses that are complicated by secondary pyoderma.

Suppositories (tablets) Clotrimazole indications for use

The drug Clotrimazole in the form of vaginal suppositories and tablets is intended for the treatment of vaginal infections in girls and women caused by a yeast-like fungus of the genus Candida. The indications also apply to superinfections that can be caused by microorganisms sensitive to the drug.

Clotrimazole cream indications

The drug Clotrimazole in the form of a cream is used to treat skin fungus and is indicated for use in the following conditions:

For mycoses of the foot, hand, torso, skin folds;
With candidal vulvitis,
With candidal balanitis;
If you have multicolored lichen,
With erythrasma;
For a fungal infection in the outer ear.

Clotrimazole solution indications

The drug Clotrimazole in the form of a solution is used to treat fungal infections. skin and mucous membranes. The drug is indicated for use:

For mycoses of the foot, hand, torso, lower limbs, skin folds, as well as the area where the beard and mustache are hairy part heads,
With pityriasis versicolor;
With erythrasma;
For candidiasis of the skin, mucous membranes and genitals;
With paronychia.

Clotrimazole contraindications

The use of the drug Clotrimazole is contraindicated in the first three months of pregnancy, as well as in case of sensitivity to the components that make up the drug.

Clotrimazole instructions for use

Clotrimazole instructions for use ointment/cream

The drug is used exclusively externally.
After preliminary cleaning, the ointment/cream is applied to the affected area of the skin in a thin layer and rubbed in with caution. This should be done three times a day.
The duration of the course depends on the severity of the disease and the effectiveness of treatment.
Dermatomycosis should be treated with ointment for at least a month.
Pityriasis versicolor must be treated for at least three weeks.
Fungal infections on the feet should be treated within two weeks after the symptoms of the disease have disappeared.

Clotrimazole instructions for use of suppositories/tablets

The drug in the form of suppositories or vaginal tablets is used exclusively topically.
Only women use the drug intravaginally.
IN evening time With the patient lying down, 1 suppository is inserted into the vagina.
Duration of treatment – six days, 1 suppository/tablet.
The course of treatment can be repeated only as prescribed by a doctor.

Clotrimazole solution instructions for use

The drug Clotrimazole in the form of a solution is used for external treatment in both adults and children.
Apply a small amount of Clotrimazole solution to previously cleaned dry affected areas and gently rub into the skin. Apply twice daily. After elimination severe symptoms use the drug for another month.
Treat tinea pedis for at least two weeks after the symptoms of the lesion disappear. It is advisable to use the solution after each water procedure.

Clotrimazole for children

The drug Clotrimazole is not prohibited for use in children. However, basic caution should be exercised when applying the drug to the baby’s delicate skin. In addition, large areas of skin should also not be covered with the drug, since it also performs a respiratory function for the child.

Clotrimazole during pregnancy

Since it is not advisable for a pregnant woman to insert an applicator into the vagina, it is not advisable to use the drug during the second half of pregnancy, although it does not adversely affect the fetus. But the use of the drug is prohibited for the first three months of pregnancy.

Information about the penetration of the drug into breast milk No. Therefore, it is better not to use it during breastfeeding.

Clotrimazole side effects

As a rule, there are no side effects associated with the use of the drug, but sometimes local irritation in the form of itching or burning, as well as allergic reactions, may occur.

Additional instructions

Do not apply the drug to the skin around the eyes.

If after a month the treatment does not give any positive results This means that it should be stopped and examined in order to clarify the diagnosis.

During development allergic reaction or local irritation, treatment should be stopped and replaced with another.

Drug interactions

A high concentration of para-hydroxybenzoic acid propyl ester can enhance the effect of Clotrimazole.

Can inhibit the effect of the drug Clotrimazole high doses Dexamethasone.

The drug itself is capable of reducing the effect of polyene antibiotics (nystatin, natamycin, amphotericin) when used simultaneously.

Clotrimazole analogues

The drug Clotrimazole has analogues in all its release forms.

Clotrimazole price

The drug has a low price, which ranges from 50 to 100 rubles, depending on the form of the drug.

CLOTRIMAZOLE is a drug used to treat fungal infections of the reproductive system.

Below you will find detailed description this medicine.

general description

CLOTRIMAZOLE has antifungal and antibacterial effects on a wide range of pathogenic microorganisms.

It destroys cell membranes and penetrates them, destroying the life-supporting systems of fungi and their spores.

How does it act on pathogenic microorganisms?

CLOTRIMAZOLE, in addition to fighting growing and dividing microorganisms, also has a protective effect, preventing new infections from entering the body.

The drug is highly effective against damage to the body by strains of the most common fungi.

Spectrum of action

CLOTRIMAZOLE is indicated for the destruction of fungi:

Candida albicans (thrush)
Candida spp. (candidiasis) and other genus Candida
Trichophyton mentagrophytes, Microsporum canis, Epidermophyton floccosum, Trichophyton rubrum, Malassezia furfur (lichens affecting the skin, hair and nails)
Staphylococcus spp. (staphylococci)
Streptococcus spp. (streptococci)
Corynebacterium minutissimum (erythrasma)
Gardnerella vaginalis and Bacteroides
Trichomonas vaginalis (trichomoniasis)

Doesn't poison healthy cells during treatment!

CLOTRIMAZOLE is practically not stored in the blood, mucous membranes and skin. Non-critical, up to 10% accumulation occurs only in the stratum corneum of the epidermis and in the keratin of the nails. The drug enters the liver in an inactive state and is excreted in feces and urine.

Available dosage forms

Vaginal cream (50 g tubes, 2% clotrimazole)
Vaginal tablets (made in the shape of a parallelepiped with rounded edges, biconvex, 6 pcs.)
Suppositories (1 piece - 100 mg of active substance, clotrimazole)
Cream for external use (in tubes weighing 20 g, 1% clotrimazole)

For external use:

Ointment (homogeneous, white, in tubes weighing 30 g, 1 g - 10 mg of active substance)
Solution (1%, in orange bottles of 15 ml and 30 ml)
Powder (1%, packaging - 30 g)

Indications for use

CLOTRIMAZOLE treats lesions of the skin and mucous membranes from fungal diseases:

Extremely effective against the most common female and male genital diseases:

Vulvovaginitis
Candidiasis vulvitis
Trichomoniasis
Balanitis

Used for lesions and repeated suppuration of the skin
Helps in the treatment of most lichens
Used before surgery and childbirth – protects against infection

Possible consequences of use

IN in rare cases CLOTRIMAZOLE may cause allergic reactions. When treating urological and genital infections, burning sensation, swelling of the mucous membrane and blood flow, cystitis, and vaginal discharge (burning sensation in the penis) may occur.

When using it on the skin, redness from capillary expansion, blisters, swelling, tingling or burning, irritation with peeling may occur. Redness, burning, itching, and tingling may also occur in the oral cavity.

If CLOTRIMAZOLE is accidentally ingested, nausea and vomiting may occur. cramping pain And functional disorders liver function, hallucinations and drowsiness. Need to take a pill activated carbon and then consult a doctor.

Interaction with other drugs

CLOTRIMAZOLE reduces the effectiveness of nystatin, amphotericin B, natamycin and other antibiotics of natural origin.

The cost of CLOTRIMAZOLE in Russian pharmacies varies depending on the dosage form from 8 to 200 rubles.

How and in what doses it is used

External treatment. CLOTRIMAZOLE is applied in a thin layer to the skin or mucous membranes - 2 to 4 times a day, apply for at least 4 weeks. The drug is completed on average two weeks after disappearance visible symptoms diseases, for example, during treatment. For erythrasma - after 2-4 weeks, for lichen - after 1-3 weeks
Treatment oral cavity . From 10 to 20 drops, that is, up to 1 ml of solution, is applied with a cotton swab or swab 3-4 times a day to the affected part of the oral mucosa. After the patient’s condition improves, continue treatment until all clinical manifestations are eliminated.
Treatment of urogenital infections. Candidal vulvitis or balanitis is treated by applying CLOTRIMAZOLE 2-3 times, the course is 1-2 weeks. Vaginitis and trichomoniasis in adolescents ─ vaginal tablets
For vaginal tablets(suppositories) an applicator is provided, it is installed in the vagina. If necessary, repeat the course
Urethritis is treated injection of a 1% solution into the urethra for 6 days. Apply 1 time in the evening, before bed. Before birth, one suppository is inserted into the birth canal once.

Contraindications

CLOTRIMAZOLE should not be used if:

The patient is hypersensitive to the drug
In the first trimester of pregnancy
Inside the vagina - during menstruation
Use with caution during breastfeeding

The cause of genital tract infections is often pathogenic fungi. Gynecological diseases such as thrush (vaginal candidiasis) require the use of effective drug, for example, Clotrimazole tablets. Among the medications prescribed by a doctor, this antifungal medication has its own significant advantages and some nuances when you should refrain from using tablets.

What is Clotrimazole

Acute infection or chronic form illnesses succumb quick treatment thanks to a drug from the group of imidazole derivatives. Clotrimazole is a broad-spectrum antifungal agent that is available in the form of vaginal tablets, ointments, suppositories and other dosage forms. An active substance that has proven effective in the treatment of certain gynecological diseases, disrupts the synthesis of ergosterol, which forms the cell membrane of the fungus, which contributes to its destruction.

A similar effect, when the active component contributes to the deformation of the cell membrane, is demonstrated by Clotrimazole tablets in relation to bacteria. By influencing the production of components that are necessary to strengthen membranes, the drug destroys the vital activity of microorganisms that provoke inflammation of the mucous membranes and skin. The main property of the drug will not manifest itself immediately: the symptoms of the disease of the female reproductive system may continue to bother you for several days after the start of using the medicine until it manifests itself.

Indications for use of Clotrimazole

Antifungal action the drug is indispensable in the treatment of a number of diseases, and the benefits are significant: lack of addiction and pronounced side effects. Active against molds, yeast-like fungi, causative agents of tinea versicolor, dermatophytes, the drug is no less useful as antimicrobial agent, which stops the growth of staphylococci, streptococci, and gram-negative bacteria. In the field of practical gynecology, the indications for the use of Clotrimazole are as follows:

thrush of the genital tract;
trichomoniasis;
genital infections;
sanitation of the birth canal before delivery;
before surgery on the genitals.

Composition of Clotrimazole

The basis medication constitutes the same name active substance– clotrimazole. Besides, vaginal tablets with rounded edges contain Excipients, which form a homogeneous structure. What else is included in Clotrimazole that helps maintain its properties? In small quantities it contains the following ingredients:

How to use Clotrimazole

Important rule in the treatment of gynecological diseases - adherence to the schedule. Clotrimazole can be used in gynecology intravaginally, i.e. inside the vagina, and both suppositories and vaginal tablets are suitable for this. Standard scheme, which is prescribed by a specialist, assumes that for three days it will be necessary to administer one tablet twice a day. If the treatment regimen provides for a weekly interval, then one tablet per day is enough. It is recommended to administer it at night because the undissolved part of the medicine may be released.

Instructions for use of Clotrimazole

Recommended by a doctor for therapy this drug It can be one-time or a course, the choice depends on the symptoms and severity of the disease. The appointment should be made individually, after anamnesis and examination. If there are no additional instructions from a specialist, then typical instructions for using Clotrimazole to get rid of an infection look like this:

Read the annotation, which states daily dose and acceptable duration of therapy. Compliance with the dosage and time period is mandatory.
Before inserting the tablet into the vagina, observing hygiene standards, you should wash your hands.
For convenience, you should take suitable posture: Lie on your back, bend your knees. The vaginal tablet should be inserted with light pressure, but carefully.
Lie in this position for a few more minutes so that the antifungal agent is evenly distributed.

During pregnancy

The period of bearing a child for a woman is associated with the risk of unpleasant sensations. Some are considered normal, while others are undesirable effects that the body can get rid of with the help of medications. Against the backdrop of unstable hormonal levels inflammatory process, similar in symptoms to candidal vaginitis, is not a rare case. How to get rid of painful discomfort in the lower abdomen and burning sensation? Use Clotrimazole vaginal tablets during pregnancy, but before doing so, be sure to consult a gynecologist.

During menstruation

If on later Clotrimazole during pregnancy is a way to quickly sanitize the birth canal before the birth of a child, but during menstruation the picture is somewhat different. This drug is not considered effective in preventing infection. Since Clotrimazole is not recommended during menstruation, it is worth starting a therapeutic course either before their onset or at the end of the cycle. The effect of the active substance will be minimal due to the risk of the tablet being washed away, so treatment of thrush with Clotrimazole will not bring desired result.

Overdose

As a way to prevent diseases caused by fungi - an affordable domestic drug. The use of Clotrimazole vaginal tablets for thrush can promote rapid recovery, but regardless of the diagnosis, discomfort, pain, the recommended dosage should be followed. Exceeding the concentration can cause undesirable reactions, worsening the course of the disease. An overdose of Clotrimazole for a woman’s body can result in such consequences as shortness of breath, fainting, arterial hypotension, urticaria.

Side effects

Even the recommended duration and frequency of use of an antifungal agent does not guarantee against the occurrence of unpleasant reactions. Weakened by infection female body will not be able to resist the action of the active substance for a long time, signaling the occurrence of undesirable consequences of using the medication through discomfort in the genital area and mammary gland. The occurrence of side effects of Clotrimazole is noticeable by the following signs:

soreness in the clitoral area;
swelling of the vaginal mucosa;
burning, itching, irritation of the vulva;
peeling;
rash;
discomfort during sexual intercourse;
burning sensation in the genital area of a man.

Contraindications

When treating a number of diseases associated with the possibility of sexual transmission of infection, each partner must undergo a course of therapy at the same time, but this is not a reason to use one remedy. For someone therapy will pass without consequences, but the drug may not be suitable for some due to individual intolerance. As with any medicine, you should take precautions or check with a specialist for some details. There are contraindications for Clotrimazole: the use of vaginal tablets should be limited or avoided in following situations:

age up to 12 years;
sensitivity to the active substance;
menstruation period;
at bloody discharge from the vagina (chronic, irregular);
irritation, swelling, rash, blisters, open wounds on the woman's genitals;
cold, fever;
nausea, vomiting, diarrhea;
back pain.

Interaction with other drugs

An antifungal drug with the same active substance can inhibit the action of other drugs. In the vast majority of cases, this refers to medications for external use, while Clotrimazole in tablets belongs to a different category of drugs. If a doctor has prescribed this broad-spectrum antifungal agent to fight an infection, then, as a specialist, he knows that vaginal tablets with this active ingredient cannot be combined with Nystatin, Natamycin or other polyene antibiotics.

There is also the opposite phenomenon, when taking certain medications can greatly affect the effectiveness of Clotrimazole. Interaction with other drugs in such cases is undesirable, since the recovery process will take time, among similar drugs– Dexamethasone. If there is a need to enhance the antimycotic properties of clotrimazole, then adding p-hydroxybenzoic acid propyl ester to the treatment regimen will help achieve the desired result, and the latter must be taken in high concentration.

Analogs

Affordable price domestic drug is one of the advantages of this antifungal agent. Few drugs belonging to its group have the same properties and spectrum of action, and yet there are analogues of Clotrimazole tablets. In cases where it is not possible to buy this medicine at a pharmacy, it can be replaced with similar products containing the same active substance. The following medications are analogues of Clotrimazole:

Price of Clotrimazole tablets

The demand for an antifungal agent is due to its effectiveness, safety, and availability. After visiting a doctor, the question becomes relevant: how much does Clotrimazole cost? It would be wrong to assume that it can be bought in an online store, like a contraceptive from a catalog. If quality is at stake, then it is cheaper to order from an online pharmacy, provided that the medicine or analogues are in stock. The price of Clotrimazole tablets (100 mg) varies, 6 pieces - from 20 to 55 rubles.

Video: Medicine Clotrimazole

Antifungal agent for topical use from the group of imidazole derivatives.

White crystalline substance, odorless. Practically insoluble in water, sparingly soluble in ether, very soluble in polyethylene glycol 400, ethanol and chloroform. Molecular weight 344.84.

Pharmacology

pharmachologic effect- antibacterial, antiprotozoal, trichomonacid, broad-spectrum antifungal.

It disrupts the synthesis of ergosterol (the main structural component of the fungal cell membrane), changes the permeability of the fungal membrane, promotes the release of potassium and intracellular phosphorus compounds from the cell and the breakdown of cellular nucleic acids. Inhibits the synthesis of triglycerides and phospholipids. Reduces the activity of oxidative and peroxidase enzymes, as a result of which the intracellular concentration of hydrogen peroxide increases to a toxic level, which contributes to the destruction of cellular organelles and leads to cell necrosis. Depending on the concentration, it exhibits a fungicidal or fungistatic effect. Inhibits blastospore transformation Candida albicans into an invasive mycelial form.

Clotrimazole acts mainly on growing and dividing microorganisms. In vitro exhibits fungicidal and fungistatic activity against dermatomycetes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast-like fungi Candida spp.(including Candida albicans). Active against the causative agent of lichen versicolor - Pityrosporum orbiculare(Malassezia furfur).

Fungal strains that are naturally resistant to clotrimazole are rare. Primary resistance to clotrimazole has only been described for Candida guillermondii.

Effective against gram-positive bacteria - the causative agent of erythrasma Corynebacterium minutissimum, and Staphylococcus spp., Streptococcus spp., gram-negative bacteria - Bacteroides, Gardnerella vaginalis. IN high concentrations active regarding Trichomonas vaginalis.

Poorly absorbed through the skin and mucous membranes.

Accumulates in the stratum corneum of the epidermis, the concentration in the deep layers of the epidermis is higher than the MIC for dermatomycetes. When applied to nails, it is found in keratin.

When administered intravaginally, 3-10% of the dose is absorbed.

In the liver it is quickly biotransformed to inactive metabolites and excreted in feces. Absorbed clotrimazole induces the activity of microsomal liver enzymes, which leads to an acceleration of its catabolism.

High concentrations in vaginal secretions and low concentrations in blood persist for 48-72 hours.

Carcinogenicity, mutagenicity, effect on fertility

There was no evidence of carcinogenicity of clotrimazole in a study in rats receiving it orally for 18 months. Long-term studies in animals have not been conducted to assess the potential carcinogenicity of clotrimazole when administered intravaginally.

A mutagenicity study in Chinese hamsters that received 5 doses of clotrimazole 100 mg/kg orally did not reveal a mutagenic effect - structural changes during metaphase in spermatophore chromosomes.

Pregnancy. In studies in pregnant rats, intravaginal administration of doses of clotrimazole up to 100 mg/kg did not reveal any adverse effects on the fetus. However, daily oral administration Clotrimazole at doses ranging from 50 to 120 mg/kg resulted in embryotoxicity in rats and mice (possibly secondary to maternal toxicity). Thus, in mice, when taking clotrimazole in doses 120 times higher usual dose in humans, in the period from 9 weeks before mating to the end of feeding, a mating disorder, a decrease in the number of viable young, and a decrease in the survival rate of offspring from birth to the end of feeding were recorded. At doses up to 60 times the normal human dose, no adverse effects were observed. In rats, at doses 50 times higher than the usual human dose, clotrimazole, over a similar observation period, caused a slight decrease in the number of pups in the litter and a decrease in their survival. No teratogenic effects were detected in mice, rabbits and rats when clotrimazole was taken orally at doses up to 200, 180 and 100 mg/kg, respectively.

Use of the substance Clotrimazole

Fungal infections of the skin and mucous membranes: dermatomycosis, dermatophytosis, trichophytosis, epidermophytosis, microsporia, candidiasis, interdigital fungal erosion, fungal paronychia; mycoses complicated by secondary pyoderma; pityriasis versicolor, erythrasma; candidal stomatitis; candidiasis vulvitis, vulvovaginitis, balanitis, trichomoniasis; for sanitization of the birth canal before childbirth.

Contraindications

Hypersensitivity.

Use during pregnancy and breastfeeding

Should not be used in the first trimester of pregnancy (adequate and strictly controlled studies have not been conducted). When used intravaginally in women in the second and third trimesters of pregnancy, no adverse effects on the fetus were detected, but the use of a vaginal applicator is undesirable.

With caution - during breastfeeding(it is unknown whether clotrimazole passes into breast milk).

Side effects of the substance Clotrimazole

Allergic reactions (itching, urticaria).

At local application on the skin: erythema, blistering, swelling, burning and tingling, irritation and peeling of the skin.

When used topically for the treatment of urogenital infections: itching, burning, hyperemia and swelling of the mucous membrane, vaginal discharge, frequent urination, intercurrent cystitis, burning sensation in the partner’s penis, pain during sexual intercourse.

When applied topically in the oral cavity: redness of the oral mucosa, burning and tingling sensation at the site of application, irritation.

Interaction

Reduces the activity (mutually) of polyene antibiotics (amphotericin B, nystatin, natamycin).

Overdose

In case of accidental ingestion of drugs, the following are possible: symptoms: anorexia, nausea, vomiting, gastralgia, liver dysfunction; rarely - drowsiness, hallucinations, pollakiuria, allergic skin reactions.

Treatment: taking activated carbon, symptomatic therapy.

Routes of administration

Locally.

Precautions for the substance Clotrimazole

Avoid contact of the drug with the mucous membrane of the eyes. Avoid use in areas where the integrity of the skin is damaged.

After applying the cream, do not use sealed dressings.

To prevent reinfection it is recommended simultaneous treatment sexual partner. Do not prescribe intravaginally during menstruation. For trichomoniasis, combined use with systemic chemotherapeutic agents (metronidazole orally) is recommended.

In patients with impaired liver function, its functional state should be periodically monitored.

The appearance of irritation or signs of hypersensitivity requires discontinuation of treatment.

If there is no clinical improvement within 4 weeks, a microbiological examination to confirm the diagnosis and exclude another cause of the disease.

Interactions with other active ingredients

Trade names

Name	The value of the Vyshkowski Index ®
	0.0225

The drug Clotrimazole cream is used for pathologies caused by fungus, for example, vaginal candidiasis or thrush. The main active substance of the product destroys fungal membranes and has a detrimental effect on pathogenic microorganisms. Thanks to the low price and positive feedback, this medicine against fungus is one of the leaders in the pharmacological market.

What is Clotrimazole cream

For fungal diseases of the skin, nails, vaginal candidiasis (thrush) it is prescribed drug therapy antibacterial ointment Clotrimazole. The drug has a strong antifungal effect on pathogens of erythrasma, fungal psoriasis and other common mycotic diseases. The doctor can prescribe an ointment at the first symptoms of infection, to prevent mycosis in the layers of the skin and on the vaginal mucosa.

The drug inhibits the growth, development and division of fungal cells. In addition, the drug is widely used for genital tract infections (for example, vaginal mycosis of the vaginal lining). To treat candidiasis, ointment is prescribed to both sexual partners. In this case, it is recommended to apply the cream both before and immediately after sexual intercourse.

The medicine in the form of a cream is a mass of pale yellow color, the consistency of fatty sour cream, packaged in an aluminum tube and cardboard packaging with an annotation for the medicine, instructions for using the antifungal drug. Clotrimazole ointment is freely available in pharmacies and online stores without a doctor's prescription.

Compound

The drug is available in several dosage forms: vaginal tablets, suppositories, ointment, cream for external use. The latter has the following composition:

The main active ingredient is clotrimazole 10 mg.
Additional substances – ethanol, Vaseline, glycerol, distilled water, solid fat.

pharmachologic effect

The drug disrupts the synthesis of ergosterol, which is part of the fungal cell membrane. Clotrimazole inhibits the cell division processes of pathogenic microorganisms and is one of the most effective antifungal agents, because it has a wide spectrum of action. The drug has a detrimental effect against gram-positive and gram-negative bacteria. Doctors recommend starting therapy at the first signs infectious lesion.

What is Clotrimazole for?

Clotrimazole cream has the following readings for use:

Instructions for use Clotrimazole cream

The medicine Clotrimazole is used for external application for antifungal therapy. The medication, according to the instructions, is applied in a thin layer 2-3 times a day. on clean and dry areas of skin with affected epidermis. If the skin has serious lesions and ulcers, to achieve best effect It is recommended to use compresses with cream for several days so that the medicine is absorbed in high concentrations. The duration of the course of therapy depends on the severity of the disease, localization of the pathology, and effectiveness.

For women

A medicine with antifungal activity, Clotrimazole, is used for women suffering from frequent exacerbations thrush, vaginitis and other bacterial lesions of the vagina. The duration of treatment is from 5 to 10 days, depending on the severity of the disease. Clotrimazole is recommended for the prevention of exacerbations of candidiasis during colds and a decrease in general immunity. The drug should be used with caution during menstruation.

For men

Clotrimazole cream for men is used mainly for the treatment of chronic and acute form candidal skin lesions of the genitals. Treatment of fungal diseases in men lasts from 4 to 7 days. It is better to start using the cream when the first signs of the disease appear: severe itching, burning, redness, pain when urinating. Good genital hygiene also helps. Do not use the cream if you are hypersensitive to the components of the drug.

Drug interactions

Some drugs (Amphotericin B, Nystatin) significantly reduce the effectiveness of Clotrimazole during simultaneous drug therapy, so they do not need to be used together. When using the medication, negative interactions with other drugs result clinical trials was not identified. Caution should be used when using the cream simultaneously with other antibiotic ointments, since the combination different groups antifungal drugs may lead to allergies.

Side effects and overdose

When using cream with Clotrimazole, local adverse reactions: itching, burning, redness of the skin at the site of application of the drug. In some cases, blisters, erythema, swelling and peeling of the skin appear. Individual intolerance to the drug is manifested by urticaria. The use of the drug in high doses does not cause life-threatening or health-threatening conditions.

Contraindications

The use of Clotrimazole is strictly contraindicated if the patient has a history of:

insufficiency of the kidneys or the urinary system as a whole;
increased sensitivity to the components of the drug;
liver failure;
open wounds on the skin;
allergic reactions.

special instructions

The antibiotic Clotrimazole is intended strictly for external use for fungal infections and other skin diseases. The medicinal product is not suitable for use in ophthalmological practice, contact of the cream with the eyes and the skin around them should be avoided. The drug should be used with caution in children under 5 years of age. Do not allow the cream to get into open wounds or damaged mucous membranes. When the first signs of an allergic reaction appear, drug therapy with the drug must be stopped.

Pregnancy and lactation

No toxic effects of the drug on the fetus have been identified; use is relatively safe at all stages of pregnancy. Therapeutic doses the medicine does not affect the development of the fetus. It is recommended to use Сlotrimazole for the prevention of fungal infections for women in the first trimester of pregnancy who have an unfavorable permanent environment (for example, if a girl works in kindergarten or medical institution). Use during breastfeeding is not prohibited if the cream does not come into contact with the mammary glands.

Analogs

Present on the pharmaceutical market a large number of medicines, similar in action to Clotrimazole, but differing in release form, price, and composition. Some may cause fewer side effects or work faster. The main analogues of Clotrimazole are:

Candide. An antifungal medication that has a wide spectrum of action against fungal microorganisms. The main active substance of Candida, clotrimazole, is a form of the substance imidazole. Due to the fact that the drug damages the membranes of fungal cells, according to reviews, it is considered one of the best antifungal agents. The cost of the medicine is about 80 rubles.
Kanizon. The drug has fungistatic and fungicidal effects, the manifestation of which depends on the doses of the drug used. The following groups of fungi are sensitive to the drug Kanizon: dermatophytes, moldy fungi, blastomycetes and dysmorphic fungi, actinomycetes. Active ingredient inhibits the synthesis of molecules of the substance ergosterol, which is necessary for the formation cell membranes pathogenic microorganisms. The price of the medicine is on average 75 rubles per package.