home Audience 3 Take thrombo ass tablets. Pharmacotherapeutic group –. Medicines similar in composition

Take thrombo ass tablets. Pharmacotherapeutic group –. Medicines similar in composition

Analgesic and non-steroidal anti-inflammatory drugs

Thrombo ASS

pharmachologic effect

Thrombo ACC antiplatelet drug containing active substance– acetylsalicylic acid – medicine group of non-steroidal anti-inflammatory drugs. The drug has antiplatelet, anti-inflammatory, antipyretic and analgesic effects.

The mechanism of action of the drug is associated with metabolic disorders arachidonic acid, due to inhibition of the enzyme cyclooxygenase. Acetylsalicylic acid is a non-selective non-steroidal anti-inflammatory drug, that is, it equally inhibits the action of cyclooxygenase-1 and cyclooxygenase-2. Acetylsalicylic acid reduces the synthesis of prostaglandins and other endogenous biologically active substances from arachidonic acid. By reducing the amount of prostaglandins in the hypothalamus in the thermoregulation center, body temperature normalizes in the case of hyperthermia. Thus, the antipyretic effect of acetyl is realized salicylic acid.

The anti-inflammatory and analgesic effect of the drug is due to inhibition of the synthesis of prostaglandins and prostacyclins in peripheral tissues and the central nervous system, as a result of which the intensity decreases inflammatory process and swelling of tissues (anti-inflammatory effect) and decreased sensitivity nerve endings to the action of chemical irritants (analgesic effect).

The drug Thrombo ACC contains a small dose of acetylsalicylic acid, as a result of which the drug’s effect on platelet cyclooxygenase predominates. The mechanism of the antiplatelet action of acetylsalicylic acid is based on its ability to inhibit the synthesis of thromboxane A2 from arachidonic acid due to inhibition of the activity of the cyclooxygenase enzyme. A decrease in the amount of thromboxane A2 in platelets helps reduce platelet aggregation and vasoconstriction. Despite the short half-life, the antiplatelet effect of the drug lasts for 5-7 days, since under the influence of acetylsalicylic acid, platelets lose their ability to aggregate throughout the entire period of life (the lifespan of platelets is about 10 days).

In addition, the drug Thrombo ACC inhibits the formation of fibrin by reducing the synthesis of thrombin and functional state fibrinogen F1. Acetylsalicylic acid promotes the activation of fibrinolysis due to the release of plasminogen activators and changes in the structure of fibrin fibers.

When using acetylsalicylic acid, there is also a decrease in the synthesis of prostacyclin, which has a gastroprotective effect, in the endothelium and gastric mucosa. The use of the drug in the form of film-coated tablets significantly reduces the irritating effect of acetylsalicylic acid on the gastric mucosa and reduces the risk of developing gastric ulcers.

After oral administration the drug absorption of acetylsalicylic acid occurs in the upper sections small intestine. Due to the enteric coating acetylsalicylic acid does not interact with the gastric mucosa and duodenum. The peak concentration of the active substance in the blood plasma is observed 3-4 hours after oral administration. Metabolized primarily in the liver with the formation of pharmacologically active metabolites. The half-life of the drug is about 15 minutes, the half-life of active metabolites is about 3 hours. It is excreted primarily in the urine, both unchanged and in the form of pharmacologically active metabolites.

Indications for use

Due to small doses of acetylsalicylic acid and a predominantly antiplatelet effect without pronounced anti-inflammatory and analgesic effects, the drug Thrombo ACC is used for treatment and prevention cardiovascular diseases in patients with the following conditions:

complex treatment of unstable angina;

prevention acute heart attack myocardium in patients with increased risk(including patients suffering from diabetes mellitus, lipid metabolism disorders, arterial hypertension, various stages obesity, as well as smokers and the elderly);

the drug is used for secondary prevention of myocardial infarction and stroke prevention in patients suffering from transient cerebral circulatory disorders;

prevention of transient cerebral circulation disorders;

the drug is also used in postoperative period in patients who have undergone vascular interventions to prevent thromboembolism (including after coronary artery bypass grafting, endarterectomy carotid arteries, arterial-venous shunting and others surgical interventions on vessels);

for the prevention of thromboembolism pulmonary artery and its branches, as well as deep vein thrombosis in patients during a period of prolonged immobilization, including after surgical interventions.

Mode of application

Enteric-coated tablets are recommended to be taken before meals. It is recommended to swallow the tablet whole, without chewing or crushing, with a sufficient amount of water.

The duration of the course of treatment and the dose of the drug are determined by the attending physician depending on the nature of the disease and individual characteristics patient.

Usually 50-100 mg of the drug is prescribed once a day.

Side effects

The drug is usually well tolerated by patients, however, some patients may develop the following side effects while taking Thrombo ACC:

From the outside gastrointestinal tract and liver: nausea, vomiting, heartburn, pain in the epigastric region, ulcerative lesions of the mucous membrane of the stomach and duodenum, transient increase in the activity of liver enzymes.

From the hematopoietic system: anemia, increased tendency to bleeding.

From the central side nervous system: headache, dizziness, tinnitus.

Allergic reactions: skin rash, itching, urticaria, bronchospasm, angioedema, anaphylactic shock.

Contraindications

Increased individual sensitivity to the components of the drug, as well as other drugs from the group of non-steroidal anti-inflammatory drugs;

erosive and ulcerative lesions of the stomach and duodenum, tendency to gastrointestinal bleeding;

intolerance to acetylsalicylic acid, bronchial asthma and recurrent nasal polyposis (aspirin triad);

use of methotrexate at a dose of more than 15 mg per week;

first and third trimester of pregnancy, lactation and childhood under 18 years of age;

the drug is not prescribed to patients suffering hemorrhagic diathesis.

In addition, caution must be exercised when prescribing Thrombo ACC to patients with a history of gastric and duodenal ulcers, nasal polyposis and drug hypersensitivity reactions.

Pregnancy

The drug is contraindicated for use in the first trimester of pregnancy, since acetylsalicylic acid increases the risk of developing defects of cardio-vascular system and other fetal development defects. Before prescribing the drug (especially if the treatment regimen requires long-term use of acetylsalicylic acid), it is recommended to exclude pregnancy. Taking acetylsalicylic acid in the third trimester of pregnancy increases the risk of complications during childbirth, and can also provoke dysfunction of the hematopoietic system in the fetus. In the second trimester of pregnancy, the drug can be prescribed under the strict supervision of a doctor if the expected benefit to the mother is higher than the potential risks to the fetus.

The drug penetrates into breast milk, if long-term use of the drug during lactation is necessary, it is recommended to resolve the issue of stopping breastfeeding. A single dose of the drug during lactation does not have a negative effect on the child and does not require stopping breastfeeding.

Interaction with other drugs

With the simultaneous use of acetylsalicylic acid and methotrexate, there is an increase in pharmacological effects the last one.

The drug enhances the effect of heparin and indirect anticoagulants, as well as thrombolytics and antiplatelet drugs (for example, ticlopidine).

When used simultaneously, the drug reduces the excretion of digoxin by the kidneys and enhances its pharmacological effects.

The drug Thrombo ACC, when used simultaneously with insulin and hypoglycemic agents of the group of sulfonylurea derivatives, enhances their hypoglycemic effect.

By displacing valproic acid from bonds with proteins, acetylsalicylic acid enhances therapeutic effects valproic acid.

When the drug is used simultaneously with ethyl alcohol, there is a mutual enhancement of the pharmacological effects of these drugs. The simultaneous use of Thrombo ACC with drugs containing ethanol, and alcohol.

When used simultaneously, the drug reduces the effectiveness of uricosuric drugs.

Glucocorticosteroids help increase the rate of elimination of acetylsalicylic acid from the body and reduce its effectiveness.

Overdose

Due to the low dose of acetylsalicylic acid in Trombo ACC, an overdose is unlikely. In case of overdose, patients experience the development of nausea, vomiting (including vomit of color coffee grounds, which indicates the development gastrointestinal bleeding), headache, dizziness, tinnitus and confusion.

There is no specific antidote. In case of overdose, gastric lavage and the use of enterosorbents and saline laxatives are indicated. If necessary, carry out symptomatic therapy. Until all symptoms of overdose disappear, it is necessary to monitor the acid-base balance.

Release form

Shelf life – 3 years.

Storage conditions

Aspirin-cardio, ACC-Ratiopharm, Kardiask.

Compound

1 enteric-coated tablet contains:

Acetylsalicylic acid – 50 or 100 mg;

Excipients, including lactose.

Attention

Before using the drug Thrombo ACC you should consult your doctor. This instruction is given in free translation and is intended for informational purposes only. To get more complete information Please refer to the manufacturer's instructions.

Drug: TROMBO ACC®
Active substance: acetylsalicylic acid
ATX code: B01AC06
KFG: NSAIDs. Antiplatelet agent
Reg. number: P No. 013722/01
Registration date: 12/29/06
Owner reg. cred.: LANNACHER HEILMITTEL Ges.m.b.H. (Austria)

DOSAGE FORM, COMPOSITION AND PACKAGING

◊ Enteric film-coated tablets white, round, biconvex; with a shiny, smooth or slightly rough surface.

1 tab. acetylsalicylic acid50 mg-"-100 mg

Excipients: lactose, microcrystalline cellulose, colloidal silicon dioxide, potato starch, talc, triacetin, silicone antifoam agent SE2, Eudrazite L30D (methacrylic acid and ethacrylate copolymer).

10 pieces. - blisters (3) - cardboard packs.

The description of the drug is based on the officially approved instructions for use.

PHARMACHOLOGIC EFFECT

NSAIDs. The mechanism of action of acetylsalicylic acid is based on irreversible inhibition of cyclooxygenase, as a result of which the synthesis of thromboxane A2 is blocked and platelet aggregation is suppressed. It is believed that there are other mechanisms for suppressing platelet aggregation, which expands the scope of its application in various vascular diseases.

It also has anti-inflammatory, analgesic and antipyretic effects.

PHARMACOKINETICS

Suction

After taking the drug orally, acetylsalicylic acid is absorbed from upper section small intestine. Cmax in plasma is observed on average 3 hours after taking the drug.

Metabolism

Acetylsalicylic acid undergoes partial metabolism in the liver with the formation of less active metabolites.

Removal

It is excreted by the kidneys both unchanged and in the form of metabolites. T1/2 for acetylsalicylic acid (ASA) is about 15 minutes, for metabolites - about 3 hours.

INDICATIONS

Prevention of acute myocardial infarction in the presence of risk factors (such as diabetes, hyperlipidemia, arterial hypertension, obesity, smoking, old age);

Secondary prevention of myocardial infarction;

Unstable angina;

Prevention of stroke (including in patients with transient disturbances cerebral circulation);

Prevention of transient cerebrovascular accidents;

Prevention of thromboembolism after operations and invasive interventions on blood vessels (such as coronary artery bypass surgery, carotid endarterectomy, arteriovenous bypass, carotid angioplasty);

Prevention of deep vein thrombosis and thromboembolism of the pulmonary artery and its branches (for example, with prolonged immobilization as a result of major surgery).

DOSING REGIME

The tablets should be taken orally, without chewing, before meals, with a glass of water. big amount liquids.

Prescribed orally 50-100 mg 1 time/day.

Thrombo ACC is intended for long-term use. The duration of therapy is determined individually.

SIDE EFFECT

Allergic reactions: urticaria, Quincke's edema, anaphylactic reactions.

From the outside digestive system: nausea, heartburn, vomiting, abdominal pain, ulcers of the mucous membrane of the stomach and duodenum (including perforated ones), increased activity of liver enzymes.

From the outside respiratory system: bronchospasm.

From the hematopoietic system: anemia (rare), increased bleeding..

From the side of the central nervous system: dizziness, tinnitus.

In general, Thrombo ACC is well tolerated by patients (due to the low content of acetylsalicylic acid in the drug). Side effects have been reported in isolated cases.

CONTRAINDICATIONS

Erosive and ulcerative lesions of the gastrointestinal tract, gastrointestinal bleeding;

- “aspirin” asthma (bronchial asthma induced by taking salicylates and NSAIDs);

- “aspirin” triad (combination bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid);

Hemorrhagic diathesis;

Combined use with methotrexate at a dose of 15 mg/week or more;

Pregnancy (I and III trimester);

Lactation ( breast-feeding);

Children's and adolescence up to 18 years old;

Hypersensitivity to acetylsalicylic acid, to excipients drug and other NSAIDs.

WITH caution prescribed for gout, hyperuricemia, ulcerative lesions Gastrointestinal tract or bleeding from the gastrointestinal tract in history, with renal and liver failure, bronchial asthma, chronic respiratory diseases, hay fever, nasal polyposis, a history of allergic reactions to medications, when used simultaneously with methotrexate at a dose of less than 15 mg/week.

PREGNANCY AND LACTATION

Application large doses Salicylates in the first 3 months of pregnancy are associated with an increased incidence of fetal defects (cleft palate, heart defects). In the second trimester of pregnancy, salicylates can be prescribed only taking into account a strict assessment of risks and benefits. The use of ASA in the last trimester is contraindicated.

Salicylates and their metabolites in small doses pass into breast milk. Long-term use salicylates is a reason to stop breastfeeding. Accidental intake of salicylates during lactation is not accompanied by the development adverse reactions in a child and does not require cessation of breastfeeding.

SPECIAL INSTRUCTIONS

ASA can provoke bronchospasm, as well as cause attacks of bronchial asthma and other reactions hypersensitivity. Risk factors include a history of bronchial asthma, hay fever, nasal polyposis, chronic diseases respiratory organs, as well as allergic reactions to other drugs (itching, urticaria).

ASA may cause bleeding varying degrees severity during and after surgical interventions.

The combination of ASA with anticoagulants, thrombolytics, and antiplatelet agents is accompanied by an increased risk of bleeding.

ASA in low doses can trigger the development of gout in predisposed individuals with reduced excretion of uric acid.

The combination of ASA with methotrexate is accompanied by an increased incidence of side effects from the hematopoietic system.

High doses of ASA have a hypoglycemic effect, which must be taken into account when prescribing it to patients with diabetes mellitus receiving hypoglycemic drugs.

When combined with GCS, it should be remembered that during treatment the level of salicylates in the blood is reduced, and after discontinuation of GCS, an overdose of salicylates is possible.

When combining ASA with alcohol, there is an increased risk of damage to the gastrointestinal mucosa and prolongation of bleeding time.

OVERDOSE

Overdose is unlikely due to the low content of acetylsalicylic acid in the drug. Exceeding the dose of ASA is associated with a risk of gastrointestinal bleeding. Overdose is especially dangerous in elderly patients.

Symptoms: nausea, vomiting, tinnitus, dizziness, confusion, general malaise.

Treatment: artificial vomiting, purpose activated carbon, laxatives; if necessary, correct the acid-base balance.

DRUG INTERACTIONS

When used simultaneously, Thrombo ACC enhances the effect of the following drugs:

Methotrexate by reducing renal clearance and displacing it from protein binding;

Heparin and indirect anticoagulants due to disruption of platelet function and displacement of indirect anticoagulants from binding with proteins;

Thrombolytic and antiplatelet agents (ticlopidine);

Digoxin due to a decrease in its renal excretion;

Hypoglycemic agents (insulin and sulfonylurea derivatives) due to the hypoglycemic properties of ASA itself in high doses and displacement of sulfonylurea derivatives from bonds with proteins;

Valproic acid due to its displacement from bonds with proteins.

An additive effect is observed when simultaneous administration ASA with ethanol.

ASA weakens the effect of uricosuric drugs (benzbromarone) due to competitive tubular elimination of uric acid.

With simultaneous use of GCS, they enhance the excretion of salicylates and weaken their effect.

CONDITIONS OF VACATION FROM PHARMACIES

The drug is approved for use as a means of OTC.

CONDITIONS AND DURATION OF STORAGE

The drug should be stored in a dry place, protected from light, out of the reach of children, at a temperature not exceeding 25°C. Shelf life - 3 years.

After visiting the doctor, the patient discovers a new drug name on the prescription list. Next to it, usually, there is a short comment indicating the rate of a single dose of the drug, multiplied by the number of doses during the day. In some cases, this information is quite enough, but not when you need to take ThromboASS.

Of course, you can look in the instructions on how to take Trombo ACC tablets; there is definitely a section there - “method of use”, indicating when to do it, before or after meals. But not as a reproach to the compilers, such instructions are designed for the average non-existent citizen. Next, there is a list of contraindications, where almost everyone finds at least one of their “sores”.

After this, complaints begin about the inattention, and even negligence, of the attending physician. “Stomach patients” are especially indignant and independently switch to analogues that do not contain acids.

So who is wrong? Doctor? Or the specialist who drew up the document accompanying the drug? The answer can be found by referring to the instructions, in the section where the composition of one tablet is described in detail.

What does TromboASS contain?

The main percentage of this drug is, of course, acetylsalicylic acid. This is something that patients suffering from gastritis and stomach ulcers do not accept.

But we should not forget that, unlike the usual ASA sold in pharmacies, ThromboASS blood thinning tablets are coated with components such as talc and eudragit.

Eudragits are derivatives of the polymerization of acrylic acid. They perform the functions of transporting the drug to a certain specified section of the intestine, protecting against the effects of stomach acid and premature absorption.

But still, emphasis on contraindications is necessary. This is the “insurance case” when the patient, having missed, “not on an empty stomach” and “without chewing”, stumbles over “with caution” and “not recommended”.

Looking under the shell, you can see that in addition to ACS, the active substance includes:

lactose;
cellulose;
silicon;
potato starch.

Lactose creates a nutrient medium for lactobacilli, stabilizing the composition of the intestinal microflora. Cellulose cleanses the intestines of toxins. Silicon binds and removes bilirubin from the body, thereby thinning the blood. Potato starch reduces acidity and improves immunity.

Having clarified the purpose of all components of the drug, we return to the main question. How to take ThromboASS, and is it really so important when to take the pills - before or after meals?

Does the thinning effect of tablets depend on the quantity, quality and time of food intake?

Research conducted on this issue has shown:

The main part of ASA is absorbed in the small intestine, or more precisely, in its upper part.
Absorption time does not depend on the degree of fullness of the stomach.
Antacids that reduce the acidity of gastric juice do not affect the rate at which the body absorbs the drug. The same can be said about milk and other products containing animal fats.

Let's turn again to the instructions, which say that Thrombo ACC tablets should be taken before meals, but not on an empty stomach. We figured out that food does not interfere with the activity of the drug.

It remains to figure out what “not on an empty stomach” means?

You should not take pills immediately after sleep. The stomach also needs time to become active. If, for some reason, the first half of the day is the best option for taking the medicine, then you should eat something first. Even if it is the most insignificant piece of food, it will serve as a command to the stomach to “go.”

ThromboASS for blood thinning, taken on a “lean stomach”, without subsequent food intake, risks dissolving in the stomach. At increased acidity environment, the main part of ASA will remain in an acidic solution, increasing the irritating effect on epithelial cells. At low acidity stomach, ASA is absorbed into the walls digestive organ and accumulates in the cells of the mucous membrane, which is not at all desirable.

As you can understand, all these precautions are associated, for the most part, with protecting the digestive system, from negative impacts ASA, and do not affect the diluting effect of the drug in any way.

How does a blood thinner work?

Absorbed into the walls of the small intestine, the active substances of the drug enter the blood and bind to its proteins. ASCs are characterized by their location outside cells. But even when bound to protein, it does not lose its activity.

ASA neutralizes thromboxane, an enzyme secreted by activated platelets that serves as a signal to activate other platelets. Deactivated platelets, until the end of their life cycle, lose their ability to aggregate, which contributes to blood thinning.

An interesting property of the ASA contained in the drug is that the drug may not be detected at all in the blood plasma (or detected in very small proportions). But, nevertheless, the suppressive effect on platelet function will be fully manifested.

Against the background of a decrease in the level of thromboxane, the content of prostacyclin in the blood increases, which is an antagonist of the platelet activation enzyme. Thus, the necessary and expected effect is achieved - blood thinning.

Since it is recommended to take Thrombo ACC to thin the blood, washing down the tablets with plenty of water or any other liquid, this will actualize the moment of action - before meals, and not after. Food with a large consistency of liquid substance makes it difficult for the stomach to work and lingers in it for a longer time.

As a rule, the doctor prescribes a one-time dose of the drug, with a recommendation for evening time. One should not look for any hidden dependencies on the body’s biorhythms or other objective reasons in this.

The evening moment, before dinner, is more important from a psychological perspective. This is the time when the day's worries, haste, and vanity have already been overcome. The body, including the brain, receives a short respite from external worries and can focus on itself. This is the most comfortable situation for correct reception tablets.

If the patient has any doubts about the relevance of the drug. If during treatment there appear pain symptoms in the stomach area, nausea, dizziness, loss of strength. You should contact your doctor immediately.

Under no circumstances should you change the dosage of the medication yourself or arbitrarily replace ThromboASS with analogues. This is the prerogative of specialists who have objective information about general condition of the patient’s body, compiled on the basis of an examination and tests taken, taking into account all risk factors.

In this medical article you can read: medicine ThromboASS. The instructions for use will explain in what cases the tablets can be taken, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the forms of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Thrombo ACC, from which you can find out whether the medicine helped in the treatment of angina pectoris and the prevention of strokes and heart attacks in adults and children, for which it is also prescribed. The instructions list analogues of ThromboASS, prices of the drug in pharmacies, as well as its use during pregnancy.

A medicine that prevents the formation of blood clots is Thrombo ACC. Instructions for use prescribe taking 50 mg and 100 mg tablets for the prevention and treatment of cardiac and vascular pathologies.

Release form and composition

The dosage form of Trombo ACC is an enteric film-coated tablet: white, biconvex, round, shiny, with a smooth or slightly rough surface (14 pcs. in blisters, 2 blisters in a cardboard pack; 20 pcs. in blisters, in a cardboard pack pack of 5 blisters). 1 tablet contains: active substance - acetylsalicylic acid - 50 or 100 mg.

pharmachologic effect

The drug contains a non-steroidal anti-inflammatory drug - acetylsalicylic acid, the mechanism of action of which is based on selectively blocking the function of the cyclooxygenase enzyme. Thus, the drug prevents the formation of substances that provoke the development inflammatory reaction– prostaglandins, prostacyclins and others.

Platelets cannot synthesize new cyclooxygenase, as a result of which the antiplatelet effect of the drug is especially pronounced due to a decrease in their adhesiveness. The action of this drug, aimed at platelets, lasts on average several days. This must be taken into account when planning surgery.

The use of Thrombo ACC reduces the adhesion of blood platelets to each other by suppressing the formation of thromboxane A2 in them. This drug helps to reduce the content of certain coagulation factors in the blood, as well as increase the fibrinolytic activity of plasma.

The drug is well and quickly absorbed from digestive tract. During absorption, partial metabolism of acetylsalicylic acid occurs, which binds to plasma proteins in the blood.

Metabolism of most of the drug occurs under the action of liver enzymes, resulting in the formation of salicylic acid, the active metabolite. Removal of metabolites from the body occurs through the work of the kidneys.

Indications for use

What does Thrombo ACC help with? Tablets are prescribed:

prevention of deep vein thrombosis and thromboembolism of the pulmonary artery and its branches (for example, with prolonged immobilization as a result of major surgery);
secondary prevention of myocardial infarction;
prevention of acute myocardial infarction in the presence of risk factors (such as diabetes mellitus, hyperlipidemia, arterial hypertension, obesity, smoking, old age);
prevention of transient cerebrovascular accidents;
unstable angina; prevention of stroke (including in patients with transient cerebrovascular accidents);
prevention of thromboembolism after operations and invasive interventions on blood vessels (such as coronary artery bypass surgery, carotid endarterectomy, arteriovenous bypass, carotid angioplasty);

Instructions for use

Thrombo ACC is taken orally with plenty of liquid, preferably before meals, but not on an empty stomach. When used to prevent deep vein thrombosis and pulmonary embolism, 100–200 mg per day is prescribed.

In other cases daily dose is 50–100 mg. Long-term therapy is indicated; its duration is determined by the doctor individually.

Read also: how to take a close analogue of Thrombo ACC for stroke prevention - .

Contraindications

Thrombo ACC should not be used if the patient is at risk of bleeding from the gastrointestinal tract due to hemorrhagic diathesis, exacerbation of a gastric or duodenal ulcer. The drug is contraindicated in cases of severe renal or liver failure, intolerance to acetylsalicylic acid or the components included in the drug.

The drug should not be used if the patient has chronic failure, bronchial asthma induced by acetylsalicylic acid, as well as simultaneous treatment methotrexate.

Thrombo ACC should not be used by women during pregnancy, in the first and third trimester, or during breastfeeding. The drug is contraindicated in children under 18 years of age.

With extreme caution this remedy prescribed to patients suffering peptic ulcer in remission, gout, chronic diseases respiratory tract, and also before surgical intervention, including before tooth extraction.

Side effects

noise in ears;
bronchospasm;
increased bleeding;
anaphylactic reactions;
abdominal pain;
Quincke's edema;
heartburn;
anemia (rare);
hives;
nausea, vomiting;
ulcers of the mucous membrane of the stomach and duodenum (including perforated ones);
dizziness.

Children, pregnancy and breastfeeding

The drug is contraindicated during pregnancy in the first and third trimesters. In the second trimester, it is prescribed only if the expected benefit to the mother outweighs the risk to the fetus.

During lactation, occasional intake of salicylates does not cause adverse reactions in the child, but if used systematically, breastfeeding should be discontinued.

Contraindicated for children under 18 years of age.

special instructions

ACC thrombo can provoke bronchospasm, as well as cause attacks of bronchial asthma and other hypersensitivity reactions. Risk factors include a history of bronchial asthma, hay fever, nasal polyposis, chronic respiratory diseases, as well as allergic reactions to other drugs (itching, urticaria).

When Thrombo ACC is combined with alcohol, there is an increased risk of damage to the gastrointestinal mucosa and prolongation of bleeding time.

Drug interactions

Salicylic acid enhances the effect the following drugs: methotrexate, anticoagulants, thrombolytic, antiplatelet agents, selective inhibitors serotonin reuptake, digoxin, oral hypoglycemic agents, valproic acid, NSAIDs and salicylic acid derivatives, ethanol.

When taken simultaneously with these drugs, it is necessary to reduce the dose of the drugs. Acetylsalicylic acid can reduce the effect of any diuretics, ACE inhibitors, drugs with uricosuric action.

When used simultaneously, an increase in their dose is required. The combination of acetylsalicylic acid and systemic corticosteroids leads to increased excretion of salicylates and a weakening of their effect.

Analogues of the drug Thrombo ACC

Analogues are determined by structure:

Vacation conditions and price

The average cost of Thrombo ACC (50 mg tablets No. 100) in Moscow is 130 rubles. Available without a prescription.

It must be stored in a dry place, protected from light, out of reach of children, at a temperature not exceeding 25 C. Shelf life - 3 years.

Acetylsalicylic acid is a powerful inhibitor of cyclooxygenase, an enzyme that is essential for the synthesis of substances involved in the process of inflammation and inflammation.

However, these same connections support normal work and other organs and systems, therefore, when taking ThromboASS, certain precautions must be taken.

The most serious side effects are the following:

NSAID gastropathy, characterized by the formation of erosions and ulcers on the mucous membrane of the stomach and duodenum, as well as, in addition, gastrointestinal bleeding.
“Aspirin asthma” is a variant of bronchial asthma. Acetylsalicylic acid, which is part of the drug ThromboASS, in this case is the provocateur of the attack.
Bleeding from mucous membranes.

How long to take ThromboASS?

Patients with cardiovascular diseases (coronary artery disease, angina pectoris, chronic heart failure, atrial fibrillation and others) ThromboASS should be taken for life.

A patient taking antiplatelet drugs should be regularly examined by his or her physician and have necessary tests blood for timely detection of treatment complications.

To prevent thrombosis during varicose veins lower limbs and other diseases ThromboASS is prescribed in limited courses, usually for 1-2 weeks, until the coagulogram is normalized and.

It should be noted that in this case greater effect will bring anticoagulants rather than antiplatelet agents.

Conditions for storing and dispensing the drug

ThromboASS can be purchased at any pharmacy.

The drug is available without a prescription, but this does not mean that it can be used as you please: acetylsalicylic acid is by no means a safe substance, and its use not in accordance with the instructions can lead to dire consequences.

The drug is stored at room temperature. It can be safely left in your home medicine cabinet. In hot weather, it is better to put the tablets in a cool place or in the refrigerator.