What do Trigan D tablets help with? Instructions for use. Trigan-d - the pills that caused a terrible epidemic of drug addiction among schoolchildren

Prohibited during breastfeeding

Prohibited for children

Has restrictions for older people

Has limitations for liver problems

Has limitations for kidney problems

Painful sensations accompany almost any disorder in the body. Often, paracetamol-based monomedicines are prescribed to relieve them, but if their use is ineffective, it is possible to use complex means. One of them is Trigan-D - a combined medication based on paracetamol and dicycloverine. This is an analgesic drug that does not contain psycholeptics.

General information about the drug

Combination active ingredients Trigan-D provides an effective analgesic and antispasmodic effect. A small content of each of the active ingredients in it provokes less side effects medicines on the body.

Paracetamol has the ability to increase the pain threshold and affect thermoregulatory centers in the hypothalamus, which allows you to adjust the temperature in the body, and dicycloverine relieves spasms.

What are these tablets used for? Trigan-D is used as a component complex therapy inflammatory pathologies, and also for blocking pain syndrome in organism. You can use the medication as a means to reduce fever.

Trigan D tablets belong to the group of medications that affect COX-1 and COX-2 in the peripheral parts of the nervous system. This is an analgesic, non-narcotic drug + antispasmodic. INN – Paracetamol + Dicycloverine.

The scope of application of the medicine is the treatment of acute and chronic pain in the musculoskeletal system, internal organs, relief of the first symptoms of infectious and viral pathologies.

Release form and cost

The drug is available in tablet form and in solution for injections. Tablets o round shape white or cream-colored with smooth edges and with a break strip. Packed in blisters of 20 pieces. The tablets are packed in boxes of 1, 2, 5 blisters, along with instructions for using the medication.

The solution is packaged in transparent ampoules of 2 ml and placed in plastic or cardboard trays of 5 pieces. The cardboard box contains instructions for the medication and a tray with ampoules.

The cost of Trigan D tablets in Russia is presented in the table.

Compound

Trigan D tablets contain 2 main active ingredients, as well as additional ingredients - glucose, gelatin, magnesium stearate and talc. The solution contains, in addition to the main ingredient, injection water. Composition of active ingredients in tablets and solution:

Pharmacodynamics and pharmacokinetics

The therapeutic effect of the drug is based on the pharmacological properties of two active substances in its composition:

The combination of two components in the drug ensures rapid relaxation of smooth muscle fibers in the internal organs, reducing the pain threshold, which leads to a long-term analgesic effect.

The drug is absorbed quite well and quickly in the digestive tract. Its maximum concentration in the blood plasma is 1-1.5 hours after taking the medication. Distribution – 3.65 l/kg. The connection with protein compounds is up to 50%, passes the placenta barrier and is diagnosed in breast milk. The half-life of the components is from 3 to 5 hours.

Paracetamol is metabolized in liver cells, and overdose can lead to kidney and liver dysfunction. 80% of the drug is excreted in the form of metabolites through the kidneys with urine, and 20% with feces.

Indications and contraindications

Main stream therapeutic action Trigan D is a relief of hyperthermic and pain syndromes. The drug is used as an antispasmodic and analgesic for acute as well as chronic pain of various etiologies. The drug is effective for relieving pain in the following pathologies:

The medication should not be used for:

• allergies to components;
• ulcerative pathologies in the digestive tract;
• kidney and liver failure;
• pathologies of hemostasis – thrombocytopenia and leukopenia;
• anemia;
• glaucoma;
• prostatitis;
• viral diseases and ARVI;
• tachycardia, arrhythmia and angina.

During pregnancy and when breastfeeding a baby, the drug should not be used due to its penetration through the placenta and into the composition mother's milk, and it is also necessary to stop taking the medication during the period of planning to conceive a child. Trigan D is not used in pediatrics (up to 7 years) and in narcology (alcohol and drug addiction).

Instructions for use

In accordance with the instructions, Trigan D must be taken orally with the required amount of purified water - 200 ml.

The drug is not intended for self-medication, and can be used in therapy only on the recommendation of the attending physician, who will prescribe required dosage, and will also describe the dosage regimen and duration of the therapeutic course.

One-time use of tablets - 1-2 pieces must be diluted in 200 ml of water. The permissible dose per day is 3 tablets. This drug Trigan-D is administered orally after meals. For acute pain syndrome, it is recommended to take 2 tablets 3-4 times a day for 1-3 days.

Dosages for children:

• 7-13 years – 0.5 tablets 2 times a day;
• 13-15 – 1 tablet, 1 to 3 times a day;
• from 15 years – adult dosages.

For elderly patients and those with renal failure, adjustments are necessary. daily dosage and duration of the therapeutic course.

Do not take the drug for longer than 3 days without a doctor’s prescription. If there is no relief during this time, then you need to contact the clinic to prescribe the correct treatment for the cause of the pain.

Possible side effects and overdose

Trigan D is well tolerated by the body, but it must only be taken according to the prescribed regimen and not exceed the therapeutic dosage. In case of hypersensitivity to the components, the negative effects of Trigan D, described in the table, may occur.

If signs appear negative effects, you need to stop taking the pills and consult a doctor. The attending physician can reduce the dosage or select analogues of the medication that will not cause blocking effects.

Consequences of an overdose of Trigan D:

• headache;
• dizziness;
• severe nausea, which may cause vomiting;
• pain in the epigastric region;
• cold extremities;
• stomach or intestinal bleeding;
• pale skin;
• hypertension;
• drowsiness and lethargy;
• disorientation;
• arrhythmia;
• coma.

If an overdose of a drug occurs, then the following measures urgently need to be taken:

• rinse the stomach;
• take sorbents that will help remove toxins from the body;
• for overexcitation and convulsions, take a Diazepam tablet;
• if the symptoms of an overdose are severe, you need to urgently take the patient to intensive care, where doctors will carry out emergency measures to restore all body functions.

Hemodialysis is not used. With prolonged drug treatment, it is necessary to control blood flow in the peripheral parts of the system, as well as monitor liver enzymes. When treating with Caffetin, you should avoid drinking alcohol, because ethyl alcohol increases the risk of side effects.

Analogues

Analogues of the drug Trigan D are drugs that have the same active substance or a similar action:

The effectiveness of the drug is high, but the substances included in its composition are characterized by big amount side effects. This limits its use. The drug is in most cases used as a symptomatic remedy.
Currently, there are many analogue drugs that relieve spasms and have an analgesic effect more gently and without consequences for the patient’s health.

The main disadvantage of the drug is that the components included in its composition have a depressing effect on the central and peripheral nervous system, which disrupts the regulation of many processes in the body, starting from adaptation eye muscles to the brightness of the light and ending with the frequency heart rate. That is why it is believed that this drug should be used only in acute and severe situations, with severe unbearable pain in the abdomen or lower back pain.

Dosage forms of the drug ( injection solution, tablets). What are the features of the drug Trigan-d?

Tablets of this drug are known as Trigan-d. This drug also contains an additional medicinal substance - the well-known paracetamol ( 500 mg). Thanks to this, Trigan-d tablets not only relieve muscle spasms, but also have an anti-inflammatory and antipyretic effect. Trigan-d tablets have White color, round shape, flat on both sides. On one of them there is a mark with which you can split the tablet in half.

The peculiarity of the drug Trigan-d is the inclusion of paracetamol in its composition. Thanks to this, the drug becomes more effective, but at the same time more toxic. It is well known that paracetamol is one of the most harmful anti-inflammatory substances. Its toxic effect is most pronounced on the liver.

Composition of the drug. Basic and auxiliary substances

Excipients of Trigan in the form of an injection solution are the following compounds:

• lemon acid;
• beta-cyclodextrin;
• propylene glycol;
• sodium chloride;
• water for injections.

• maize starch;
• microcrystalline cellulose;
• silica;
• Magnesium stearate.

Mechanism of action of the drug. Effects of the drug ( analgesic, antispasmodic, anti-inflammatory)

Trigun has the following effects:

• Antispasmodic effect. Provided with dicycloverine. This substance inhibits acetylcholine receptor sites on smooth muscles. Thanks to this, the smooth muscles of the bronchi, stomach, intestines, bladder and bile ducts relax. As a result, the flow of pain signals associated with strong muscle contraction stops. In addition, dicycloverine is able to block some other inflammatory mediators ( for example, bradykinin and histamine), which cause muscle spasms.
• Anti-inflammatory effect. This effect provides paracetamol, which is part of Trigan-D tablets. This substance blocks the enzyme cyclooxygenase. This enzyme produces the main inflammatory mediators ( prostaglandins). This reduces inflammation in all areas of the body. It is worth noting that the anti-inflammatory effect of paracetamol is less pronounced than the antipyretic and analgesic effect.
• Antipyretic effect. Due to the presence of paracetamol in the drug. Paracetamol reduces the excitability of the thermoregulation center in the brain stem and hypothalamus. Thanks to this, after using the drug, body temperature is established within normal values.
• Analgesic ( painkiller) action. The analgesic effect of paracetamol is associated with its effect on pain centers in the brain. In addition to the central action, the drug eliminates the cause of pain if it is caused by muscle spasm ( thanks to the action of dicycloverine).

Trigan ( dicycloverine) as an M-anticholinergic blocker. The effect of the drug on human systems and organs

Trigan as an M-anticholinergic agent causes the following effects:

• dilation of the pupils of the eyes;
• increased intraocular pressure;
• deterioration of eye accommodation ( possible short-term myopia);
• increased heart rate ( acetylcholine normally has an inhibitory effect on heart rate);
• decreased secretion of the digestive glands ( salivary glands, gastric glands, pancreas);
• decreased secretion in the bronchial tree;
• reduction of sweat formation.

Is the drug a narcotic substance?

With a single use, instead of one tablet of 4-5 pieces, rapid heartbeat, psychomotor agitation, hallucinations, disorientation, loss of control over one’s own actions, aggression or depression may occur. This condition can last up to 12 hours. If the drug is used repeatedly in such quantities, symptoms may develop. mental disorders, as well as mental ( but not physical) dependence on the drug.

It is worth considering that a single dose of 4 – 5 Trigan tablets is very dangerous to health. In addition to the side effects associated with the presence of dicycloverine in its composition ( blurred vision, hallucinations, loss of orientation, self-control), an overdose of paracetamol is very toxic to the liver and can lead to cirrhosis. Thus, the drug must be taken strictly in doses recommended by the doctor or official instructions.

Analogues of the drug Trigan

In other cases, anti-inflammatory, analgesic and antipyretic drugs can serve as an analogue of the drug ( similar in properties to paracetamol). They cannot eliminate muscle spasm, but they eliminate pain. In case of abdominal pain, use as the only drug is not recommended, as it hides the symptoms of the disease ( it can come at lightning speed). That is why anti-inflammatory and painkillers are best used for pain in any other localization, except for abdominal pain.

There are also various combination drugs ( these include trigan in tablet form), which combine both an antispasmodic and an anti-inflammatory substance. Among them are spazgan, spazmalgon. These drugs eliminate pain of various origins very well, have fewer side effects, so they can be considered the best analogues Trigan drug.

Trigan and antispasmodics ( spazgan, no-shpa)

Among the antispasmodics, the following trigan analogues can be distinguished:

• hyoscine;
• mebeverine;
• spazgan;
• spasmalgon and others.

Spazgan ( spasmalgon) is a combination drug that contains three components - analgin ( 500 mg), pitofenone ( 5 mg, antispasmodic) and fenpiverinium bromide ( 0.1 mg, anticholinergic agent). The drug has a complex effect on smooth muscles, eliminating pain in several ways. Thanks to this, the drug is more effective than Trigan. The amount of anticholinergic blocker in it is minimal ( only 0.1 mg), making it a safer drug and does not cause mental disorders in case of overdose. Spasmalgon is intended for intramuscular administration, while spasgan is taken orally in the form of tablets.

Trigan and non-steroidal anti-inflammatory drugs ( ketonal, paracetamol, naproxen)

Trigan analogs among anti-inflammatory drugs are the following drugs:

• paracetamol;
• ketorolac and others.

Indications for use of trigan

Intestinal, renal or hepatic colic

Intestinal colic can occur with the following diseases:

• toxic intestinal infection ( botulism, E. coli, dysentery, salmonellosis and others);
• intestinal obstruction ( intestinal blockage by foreign bodies, tumor, intestinal stones, intestinal adhesions).

Renal colic is an acute attack of pain in the lumbar region, which is caused by a violation of the outflow of urine. Renal colic is characterized by a cramping type of pain with its spread to the groin, genitals, and leg. Most often, renal colic occurs when urolithiasis, less often - with kinking of the ureters, kidney injuries, infectious diseases.

Biliary colic manifests itself in the area of ​​the right hypochondrium, most often observed after taking fatty or spicy food. The nature of the pain is varied, most often it is stabbing, cutting, constant, and less often manifests itself as attacks. Biliary colic occurs when cholelithiasis and cholecystitis and is caused by blockage of the bile ducts by a stone. Without urgent provision help this state can lead to infection of the gallbladder and the need for surgical removal.

In the treatment of renal and biliary colic trigan is a must for use, as it not only eliminates pain, but also fights the mechanism of its development. Relieving muscle spasm increases the chance to a certain extent independent exit urinary or gallstones naturally. Otherwise, it is necessary to assist the patient through surgery. Pain with intestinal, renal or hepatic colic is very severe, so it is important to give the drug to the patient as soon as possible and seek help from specialists.

Headache and toothache

Headache can be caused by the following diseases and pathological conditions:

• cervical osteochondrosis;
• increased intracranial pressure;
• pinching of the occipital and cervical nerves;
• migraine;
• traumatic brain injuries;
• spasm of cerebral vessels;
• tension headache and other conditions.

Toothache is one of the most acute pains that a person encounters in his life. In most cases, toothache is caused by an infection in the nerve located inside the tooth. So, it can be observed with caries, pulpitis or periodontitis. In order to get rid of toothache, it is necessary to have the diseased tooth treated by a dentist. There is no need to be afraid of doctors, because modern treatment teeth is absolutely painless. Otherwise there may be various complications, in which the pain can be even more severe. Trigan can be used for toothache only for temporary relief. You need to understand that it is not able to effectively fight infection in the oral cavity.

Neuralgia

Neuralgia pain is paroxysmal in nature and may be accompanied by muscle cramps, redness of the skin, and lacrimation ( for trigeminal neuralgia), breathing problems ( with neuralgia of the intercostal nerves). Sometimes neuralgia becomes constant pain, only taking painkillers can save you from it.

Treatment of neuralgia is a very difficult task. Correct definition The reasons for the development of neuralgia can only be determined after a thorough examination. As drug treatment In almost all cases, anti-inflammatory and painkillers are used. Vitamin B injections and physiotherapy have a good effect ( the use of pulsed currents, acupuncture, infrared radiation).

Trigan is enough good drug for neuralgia. It has all the qualities necessary to treat neuralgia. Paracetamol in its composition reduces inflammation, slows down the formation of pain thanks to central action, and dicycloverine relieves spasm of the muscles located in the area of ​​innervation of the affected nerve. However today on pharmaceutical market you can find drugs that have a more pronounced analgesic and anti-inflammatory effect ( ketoprofen, ketorolac, meloxicam). They are the ones given preference in the treatment of neuralgia.

Does trigan help with muscle pain ( myalgia)?

Trigan can be used for muscle pain, but it is not the most the best drug for their treatment. On the skeletal ( striated) only paracetamol affects the muscles, since dicycloverine relieves spasm of the smooth muscles located in the internal organs. The role of paracetamol is to reduce inflammation in the area of ​​the damaged muscle.

IN in rare cases muscle pain is caused by acute circulatory disorders ( so-called heart attack). In this case, the blood clot closes the lumen of the vessel and the nutrition of the muscle is disrupted. In this case, urgent assistance from qualified doctors is necessary, since delay can lead to necrosis ( death) muscle cells. Muscle pain can also have different rare causes, the diagnosis of which may require special studies ( ultrasound or magnetic resonance imaging). In general, Trigan, like other antispasmodics, should be considered ineffective for muscle pain.

Trigan for menstruation

Antispasmodics have the best effect during menstruation ( this also includes trigan). This group of drugs relaxes smooth muscles, eliminates convulsive compressions and contractions of the uterus and other muscle organs. Thanks to this, the pressure on the vessels and nerves is reduced, the spasm is eliminated and the pain subsides. It is important not to use too many medications during your period, as this can easily lead to an overdose. Besides the trigun good effect during menstruation, drotaverine, no-shpa, spasmalgon and other analogues provide relief.

Can Trigan be used at elevated temperatures?

An increase in body temperature is most often a sign infectious inflammation. Paracetamol can prevent the progression of inflammation. If your body temperature does not exceed 37.5 degrees, then you can count on an improvement in your condition after taking Trigan. However, at higher temperatures, you should consult a doctor without waiting for the disease to develop.

Contraindications to the use of trigun

• Hypersensitivity to paracetamol and dicycloverine. This circumstance characterizes an allergy to the active components of the drug. The use of Trigan in allergy sufferers can cause anaphylactic shock or other reactions that threaten the patient's life.
• Obstruction ( obstruction) intestines, biliary and urinary tracts. With mechanical blockage of the intestines, biliary and urinary tracts, the use of antispasmodics is not always effective. This is due to the fact that if the intestinal lumen is closed by a tumor, adhesive process or a large foreign body, the drug will not be able to “remove” it from the body. This requires only surgery. For determining accurate readings To surgical treatment obstructive obstruction requires a thorough examination by a specialist. The use of antispasmodics will lead to expansion of the section preceding the level of obstruction, filling it with gas and liquid, proliferation of pathogenic bacteria and necrosis ( mortification) parts of the intestinal wall.
• Exacerbation of stomach ulcers and duodenum. The drug contains a non-steroidal anti-inflammatory drug ( paracetamol), which, when used internally, can damage the mucous membrane of the stomach and duodenum. It is very important not to use the drug during an exacerbation of peptic ulcer disease, since the drug sharply reduces the protective ability of the stomach wall from factors that cause ulcers.
• Hypovolemic shock and acute bleeding. Due to the use of dicycloverine, blood pressure may decrease. The mechanism of this phenomenon is the relaxation of the smooth muscles of blood vessels and their expansion. With bleeding and hypovolemic shock, blood pressure is already at a low level, and an even greater drop in pressure can lead to severe oxygen starvation of the brain and other organs and systems.
• Myasthenia. It is an autoimmune disease characterized by rapid fatigue of skeletal muscles. Antispasmodics worsen the course of the disease in patients suffering from myasthenia gravis.
• Pregnancy and breastfeeding. The drug is not recommended for use by pregnant women to avoid complications in the fetus.
• Children's age up to 15 years. The drug may negatively affect the developing organs of the child ( especially paracetamol), so before reaching adolescence It is better not to use it.

In what cases should the drug be taken with caution?

Trigan should be taken with caution in the following conditions:

• Severe liver or kidney dysfunction. In case of functional liver failure or renal failure, the toxicity of both active components of the drug sharply increases. Their elimination is almost entirely carried out through these organs. With functional insufficiency, the rate of their elimination slows down, as a result they can cause a variety of side effects and complications.
• Glaucoma. Glaucoma is an increased intraocular pressure. Dicycloverine, as an anticholinergic blocker, has the property of increasing intraocular pressure. Because of this, the disease can progress.
• Liver diseases ( viral hepatitis, hyperbilirubinemia, alcoholic liver damage). Paracetamol is very toxic substance for the liver. He can call sharp violation liver functions at the slightest excess of permissible doses. For liver diseases, it is recommended to use smaller doses of paracetamol, and also monitor its condition using a blood test for the activity of liver enzymes.
• Autonomic nervous system disorders ( vegetative-vascular dystonia). Vegetative-vascular dystonia is a disease that is characterized by an imbalance of the sympathetic and parasympathetic nervous systems. It manifests itself in anomalies blood pressure, heartbeat, body temperature, urination and other processes. Use of dicycloverine ( anticholinergic) introduces an even greater imbalance in nervous regulation.
• Heart diseases. A rare side effect of dicycloverine is increased heart rate. Sometimes the drug causes changes in blood pressure. All this negatively affects the functioning of the heart.

Can Trigan be used by pregnant women and breastfeeding mothers?

Dicycloverine has not been as well studied as paracetamol in relation to the mother's body. However, the manufacturer does not recommend taking Trigan during pregnancy due to the large number of possible side effects. Thus, both components of Trigan are not recommended for use during pregnancy and breastfeeding.

Can Trigan be used to treat children?

Trigan in the form of an injection solution does not contain paracetamol. Thanks to this, the drug can be used in more early age. The manufacturer indicates the minimum permitted age for using this drug is 6 months. However, when treating children with Trigan, it is necessary to consult a pediatrician about the dosage and duration of treatment with this drug.

Allergy and hypersensitivity to paracetamol and dicycloverine

You can suspect an allergy to any medications if there are other allergic diseases or in case of food allergies. Bronchial asthma is one such disease. It is in the patient's best interest to inform the doctor of the presence of any allergies before prescribing the drug. In controversial cases, the doctor may refer the patient for a consultation with an allergist. Sometimes an allergic reaction can develop in relation to excipients, rather than the main substances.

Instructions for using trigun

How to properly administer drug injections?

Only this product is approved for use by children. dosage form because it does not contain paracetamol. However, when treating children, adjustments must be made for age. The maximum single dose of dicycloverine is from 5 to 10 mg ( quarter or half ampoule) depending on the age of the child. From the age of 18 years, adult doses can be used.

Trigan injections are performed exclusively intramuscularly. The drug should not be administered intravenously, subcutaneously or otherwise. An intramuscular injection is usually performed in the upper outer corner of the buttock. It is impossible to give yourself such an injection on your own, so you need to take the help of people who have experience in this. It is very important to maintain sterility, wash your hands with soap, wipe the injection site with an alcohol wipe, and use disposable syringes and needles. With the correct technique, the injection is painless and does not leave any marks in the form of lumps or redness of the skin.

How to take Trigan-D tablets?

The maximum daily dose of the drug is 4 tablets. Exceeding this dose is dangerous to health, since taking more than 2 grams of paracetamol per day can lead to liver failure. Also, with prolonged use of trigan in the form of tablets ( more than 5 days) it is recommended to monitor liver function and cellular composition blood, having done a general and biochemical blood test.

The drug should be taken during or after meals with a sufficient amount of liquid. The use of the drug does not necessarily have to be closely related to food intake, however, it is most often recommended to take a Trigana tablet immediately after a meal. When using a trigun as antispasmodic it is necessary to undergo treatment under the supervision of a doctor in order to provide timely assistance if the patient’s well-being worsens.

How long can I continue treatment with Trigan?

The most effective form drug ( in the form of injections) is used for no more than 2 days. Trigan-D tablets can be used for no longer than 5 days. If the tablets are used as an antipyretic, the maximum duration of their use is 3 days. If the patient feels that the drug does not have a therapeutic effect or his condition worsens, it is recommended to consult a doctor and change treatment.

How quickly does the drug take effect?

How long does the drug remain in the blood?

Shelf life and storage conditions of the drug

The drug, both in the form of tablets and ampoules, should be stored in closed packaging at a temperature of 15 to 25 degrees. Ampoules of the drug do not need to be refrigerated or frozen, since the temperature in it is about 10 degrees. The drug should be stored in a dark place inaccessible to sunlight. It should not fall into the hands of children, since an overdose if used carelessly can create a serious health hazard.

Side effects of the drug

• Gastrointestinal tract disorders. Red blood cells may appear in the blood ( anemia) and a decrease in hemoglobin levels.
• Kidney damage. Have various manifestations, from urinary retention to nephritis. Also due to the presence of paracetamol in the drug.
• Liver damage. With prolonged use of the drug, an increase in the activity of liver enzymes is observed. In extreme cases, short-term jaundice develops. If recommended doses are exceeded, necrosis of the liver tissue and acute failure of liver function may occur.
• Visual impairment. Caused by impaired accommodation of the eye muscles. For some time after using the drug, the eye loses the ability to focus on objects located at different distances, which is why the patient experiences blurred vision.

Hallucinations and drug intoxication from using the drug

Using a trigan to achieve drug intoxication is unsafe for health. Firstly, damage is caused to a person’s mental state and consciousness. Secondly, large doses of Trigan contain toxic doses of paracetamol, which kill liver tissue. That is why it is very important to use the drug according to the doctor’s recommendations and protect children from careless use of the drug.

Trigun overdose and poisoning

Trigan overdose is characterized by the following symptoms:

• tachycardia ( rapid heartbeat);
• fever;
• excitation;
• muscle cramps;
• lack of appetite;
• disorientation in space;
• visual hallucinations;
• yellowness of the skin;
• disturbance of consciousness.

It is very important for patients with impaired liver or kidney function to undergo treatment with Trigan under the supervision of a physician. This is due to the fact that the rate of elimination of the drug in this category of patients is slowed down, and normal doses of the drug can cause poisoning.

Is the drug addictive?

Does the drug affect the ability to drive a car or use other machinery?

Can the drug be used together with alcohol?

Interaction of Trigan with other drugs

The effect of trigan is enhanced by the following groups of drugs:

• antiarrhythmic drugs;
• antipsychotics;
• narcotic painkillers.

Trigun prices in Russian cities

Is it possible to purchase the drug in pharmacies without a doctor's prescription?

Name:

Trigan-D

Pharmacological
action:

Included in the drug paracetamol has analgesic, antipyretic and minor anti-inflammatory effects.
Mechanism of action associated with moderate inhibition of cyclooxygenase-1 and, to a lesser extent, cyclooxygenase-2 in peripheral tissues and the central nervous system, resulting in inhibition of the biosynthesis of prostaglandin modulators pain sensitivity, thermoregulation and inflammation.
Second component dicycloverine hydrochloride a tertiary amine that has a relatively weak, non-selective m-anticholinergic and direct myotropic antispasmodic effect on the smooth muscles of internal organs.
In therapeutic doses, it causes effective relaxation of smooth muscles, which is not accompanied by the side effects characteristic of atropine.
The combined action of the two components of Trigana-D ensures relaxation of the spasmodic smooth muscles of the internal organs and alleviation of pain.

Pharmacokinetics
The drug is well absorbed from the gastrointestinal tract. Cmax in blood plasma is achieved after 60-90 minutes. Vd - 3.65 l/kg.
Paracetamol is metabolized in the liver to form several metabolites, one of which N-acetyl-benzoquinomine, under certain conditions (overdose of the drug, lack of glutathione in the liver) can have a damaging effect on the liver and kidneys.
About 80% of the drug excreted in urine and small amounts in feces.

Indications for
application:

Spasm of smooth muscles of internal organs;
- intestinal, hepatic and renal colic;
- algodismenorrhea;
- headache, toothache, migraine pain;
- neuralgia;
- myalgia;
- infectious and inflammatory diseases accompanied by fever.

Mode of application:

Applicable orally for adults and children over 15 years of age 1 tab. 2-3 times/day.
The maximum single dose for adults is 2 tablets, daily 4 tablets. The duration of use without consulting a doctor is no more than 5 days when prescribed as an analgesic and 3 days when prescribed as an antipyretic.
With prolonged use of the drug, monitoring of the peripheral blood picture and the functional state of the liver is necessary.
Do not exceed daily dose; its increase or more long-term treatment possible only under the supervision of a doctor, because An overdose of the drug can cause liver failure.

Side effects:

From the gastrointestinal tract: dry mouth, loss of taste, loss of appetite, epigastric pain, constipation, increased activity of liver enzymes, usually without the development of jaundice, hepatonecrosis (dose-dependent effect).
Allergic reactions: skin rash, itching, urticaria, Quincke's edema, exudative erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).
From the central nervous system (usually develops when taking high doses): drowsiness, dizziness, psychomotor agitation and disorientation.
From the outside endocrine system : hypoglycemia, up to hypoglycemic coma.
From the hematopoietic organs: anemia, methemoglobinemia (cyanosis, shortness of breath, heart pain), hemolytic anemia (especially for patients with gluco-6-phosphate dehydrogenase deficiency).
From the genitourinary system: pyuria, urinary retention, interstitial nephritis, papillary necrosis.
From the organs of vision: mydriasis, blurred vision, paralysis of accommodation, increased extraocular pressure.
- decreased potency.

Contraindications:

Hypersensitivity to paracetamol and dicycloverine;
- obstructive bowel diseases;
- peptic ulcer of the stomach and duodenum (acute phase);
- reflux esophagitis;
- hypovolemic shock;
- myasthenia gravis;
- pregnancy;
- lactation period;
- children's age (up to 15 years).

Use with caution in patients with a genetic absence of glucose-6-phosphate dehydrogenase, blood disease, glaucoma, benign hyperbilirubinemia (including Gilbert's syndrome), viral hepatitis, alcohol impairment liver, alcoholism, old age.

With caution and under the supervision of a physician, the drug should be used in patients with impaired liver or kidney function, simultaneously with other anti-inflammatory and analgesic drugs, as well as with anticoagulants and drugs that affect the central nervous system.
If you are taking metoclopramide, domperidone or cholestyramine, you should also consult your doctor.
Paracetamol distorts indicators laboratory research in the quantitative determination of uric acid and glucose in plasma.
To avoid liver toxicity, paracetamol should not be combined with taking alcoholic drinks , and also taken by persons prone to chronic alcohol consumption.
The risk of developing liver damage increases in patients with alcoholic hepatosis.
Impact on the ability to drive vehicles and operate machinery
When using the drug, you should refrain from potentially dangerous species activities requiring increased concentration and speed of psychomotor reactions (driving vehicles, etc.)
During long-term treatment monitoring of the peripheral blood picture and the functional state of the liver is necessary.

Interaction
other medicinal
by other means:

The effect of dicycloverine is enhanced by amantadine, class I antiarrhythmic drugs, antipsychotics, benzodiazepines, MAO inhibitors, narcotic analgesics, nitrates and nitrites, sympathomimetic drugs, tricyclic antidepressants.
Dicycloverine increases the concentration of dioxin in the blood(due to slower gastric emptying).
Stimulators of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxications with small overdoses of paracetamol.
Adrenergic stimulants, as well as other drugs with anticholinergic effects, increase the risk of side effects. Mykerosomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxicity.
Reduces the effectiveness of uricosuric drugs.
Paracetamol increases the effectiveness of indirect anticoagulants.

20 mg dicycloverine hydrochloride.

Additional substances: microcrystalline cellulose, starch, silicon dioxin, magnesium stearate.

Release form

The white tablets are flat, round in shape, with beveled sides and a notch on one edge.

10 tablets in a blister or strip, two blisters or ten strips in a pack of paper.

pharmachologic effect

Analgesic, anti-inflammatory, antispasmodic, antipyretic.

Pharmacodynamics and pharmacokinetics

There is no information about Trigan-D on Wikipedia, and the interested category of people have questions “Trigan-D, what is it?” or “What is Trigan-D?”

Microsomal oxidation inhibitors reduce the possibility of occurrence hepatotoxic actions.

Adrenergic stimulants And anticholinergic drugs increase the risk of developing undesirable effects.

Paracetamol activates the action indirect anticoagulants.

Terms of sale

Over the counter.

Storage conditions

• Store in a dry, dark place.
• Observe temperature regime up to 25 degrees.
• Keep away from children.

Best before date

Three years.

special instructions

During treatment with the drug, you should refrain from driving a car.

Analogues

Level 4 ATX code matches:

Duspatalin, Mebsin Retard, Moreaze SR, Trimpa.

For children

Admission to persons under 15 years of age is prohibited.

With alcohol

It is forbidden to combine it with alcohol to avoid toxic damage to the liver. The risk of liver damage increases in people with alcoholic hepatosis.

During pregnancy (and lactation)

It is prohibited to use the drug during these periods.

Reviews about Trigan-D

According to reviews, the product helps to effectively relieve spasms and pain in the vast majority of cases.

The narcotic effect of Trigan-D and its use as a drug by purification from. As a result, after consuming the resulting substance, side effects occur on the psyche and nervous system, called “highs.” You should know that this is an extremely harmful effect that can lead to irreparable consequences. On specialized forums there are often questions like “how to beat off paracetamol from Trigan to get the drug? We strongly advise you not to engage in such experiments with medications and your body.

Trigan-D price, where to buy

The average price of Trigan D No. 100 in Ukraine is 302 hryvnia, and in Russia – 316 rubles.

• Online pharmacies in Russia Russia
• Online pharmacies in Ukraine Ukraine

Education: Graduated from Vitebsk State medical University specialty "Surgery". At the university he headed the Council of the Student Scientific Society. Advanced training in 2010 - in the specialty "Oncology" and in 2011 - in the specialty "Mammology, visual forms of oncology".

Experience: Worked in a general medical network for 3 years as a surgeon (Vitebsk Emergency Hospital, Liozno Central District Hospital) and part-time as a district oncologist and traumatologist. Worked as a pharmaceutical representative for a year at the Rubicon company.

Presented 3 rationalization proposals on the topic “Optimization of antibiotic therapy depending on the species composition of microflora”, 2 works took prizes in the republican competition-review of student scientific works(categories 1 and 3).

NOTE! Information about medications on the site is for reference and general information, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment. Before using the drug drug Trigan-D Be sure to consult your doctor.

Anna Rybak | 14:48 | 04.04.2019

Prescribed me Trigan-D Family doctor, because Often there are pains in the intestines due to colitis and I couldn’t stop them with the usual no-shpa, but Trigan helps excellently. In principle, as well as as a universal pain reliever.

Lelka | 13:49 | 30.03.2019

I have known Trigan-D for quite some time. I always knew that it would help relieve many types of pain. But I didn’t even imagine that it was also quite effective as a drug for relieving fever. I encountered this for the first time recently when I was being treated for the flu, and I was pleasantly surprised.

Dasha | 13:53 | 06.02.2019

In our family, Trigan is one of the drugs that we always have on hand. It so happened that at one time his parents began to accept him from time to time. And then, when I grew up and got married, I brought the old and familiar painkiller into our family. It suited my husband too. Therefore, I definitely give the drug a thumbs up.

Natalie | 21:24 | 30.12.2018

I have encountered Trigan-D more than once in my life. I took it for headaches and for dysmenorrhea. I like. that it relieves spasms very well. And not just pain relief. During critical days It is this combination of analgesic effect and spasm relieving effect. especially valuable.

Ksyu | 6:56 | 04.12.2018

I always have Trigan-D in my purse. I wear it in case I suddenly get a headache or other pain. The drug removes any of them very well and quickly. Moreover, the effect after taking it lasts for at least a day.

Elena | 1:08 | 10.08.2018

Previously, I took Trigan D, drank it for headaches, then switched to other medications. But I still remember Trigan D as a good and effective remedy

Ilona | 2:21 | 08.08.2018

They are cheaper than the drugs I took before. And they work just as well. I often save myself from cramps. Sometimes I also drink for muscle pain.

Vladimirovich | 3:05 | 24.12.2017

We have Trigan D in our first aid kit. An effective remedy against pain, and also relieves muscle spasms well.