Diseases, endocrinologists. MRI
Site search

Thyroid diseases. Autoimmune Hashimoto's thyroiditis. Promising treatments for thyroid diseases

The thyroid gland is a butterfly-shaped organ located in the front of the neck. This gland internal secretion affects almost all types of metabolism in our body and synthesizes several hormones (thyroxine, triiodothyronine and calciotonin).

Thyroxine (or T4) and triiodothyronine affect the functioning of the reproductive, digestive and cardiovascular systems, regulate mental activity and control the processes of protein, carbohydrate and fat metabolism. A special type of thyroid cells releases a hormone into the blood called calciotonin, which is involved in the processes of regulating calcium levels in the body.

At various pathologies of this endocrine gland in humans there is a significant deterioration general well-being and health status, since this small organ affects many systems and processes in the body. Such changes are caused by insufficient or excessive amounts of hormones thyroid gland, its increase in size or a combination of these two pathological factors.

The nature of the first signs of thyroid disease will depend on the level of hormones it produces. Install accurate diagnosis in such cases, various instrumental and laboratory techniques allow (blood test for thyroid hormone levels, ultrasound, scintigraphy, puncture biopsy, etc.). However, the first symptoms can help to suspect the development of pathologies of this organ.

15 Symptoms of Thyroid Problems

You can suspect problems with the functioning of the thyroid gland based on the following symptoms:

  1. Sadness, fatigue and depression or irritability, emotional lability and anxiety. Thyroid hormone levels directly affect our mood. With hypofunction of the gland (hypothyroidism), there is a decrease in the level of serotonin in the brain and the appearance of causeless sadness, constant fatigue and depression, and with hyperfunction (hyperthyroidism) - increased anxiety, irritability, restlessness and restlessness.
  2. Fever or chills. Violation of the synthesis of thyroid hormones leads to disruption of thermoregulation processes. If their amount is excessive, the patient notes attacks of fever and increased sweating, and if their level is insufficient, a feeling of chills.
  3. Loss or speed dial weight. Fluctuations in body weight are the most common and characteristic signs indicating a malfunction of the thyroid gland. With hypothyroidism, the patient experiences weight gain, and with hyperthyroidism, rapid weight loss.
  4. Digestive disorders. Thyroid hormones affect the functioning of all organs digestive tract. With hypothyroidism, a person may experience flatulence caused by slower peristalsis, and with hyperthyroidism -. If the level of thyroid hormones is insufficient, the thyroid gland is disrupted - stagnation of bile is observed in it and increases.
  5. Hair loss, changes in the quality of skin and nails. With hyperthyroidism, the following changes in the skin may be observed: (especially), thickening of the skin on the legs and feet (in later stages of the disease). Hypothyroidism causes dry skin, flaking areas, a yellowish tint to the skin, and brittle nails. and deterioration in their quality is observed with any type of hormonal imbalance. After treatment, skin, nails and hair disorders are eliminated.
  6. Decrease or increase in temperature.With hypothyroidism, the patient experiences a slight decrease in body temperature (up to 36.0-36.1 °C). In normal conditions, this violation of thermoregulation is not dangerous, but with the development of infectious diseases, this symptom can cause the first signs of an infectious disease to be missed and contribute to its more severe course. With hyperthyroidism, the patient experiences a constant slight increase in temperature to 37.1 – 37.5 °C.
  7. Eye symptoms: bulging eyes, photophobia, infrequent blinking and lacrimation. Such changes are observed with hyperfunction of the gland. With diffuse toxic goiter The patient develops disthyroid orbitopathy, accompanied by swelling and infiltration of elements of the connective tissue of the external muscles of the eye and orbital tissue. Patients complain of blurred vision, photophobia, a feeling of fullness in the eye, and frequent lacrimation. Painful sensations in the eyeballs do not occur or are moderate. As the disease progresses and the external eye muscles increase, the patient develops exophthalmos (bulging eyes).
  8. Unstable menstrual cycle. observed in both hypo- and hyperfunction of the thyroid gland. With hypothyroidism, women complain of infrequent and scanty periods (up to amenorrhea), and with hyperthyroidism - of an unstable menstrual cycle. Many patients with thyroid pathologies face difficulties in conceiving and the inability to bear a child.
  9. Decreased libido, potency disorders. Any type of dysfunction of the thyroid gland leads to a decrease in libido and can cause impotence in men. Sometimes, with severe hyperthyroidism in men, it is observed.
  10. Discomfort in the throat and swelling of the neck. An increase in the size of the gland or the appearance of nodes on it can lead to changes in the timbre of the voice, coughing, difficulty swallowing food or saliva, asymmetry in the front of the neck, swelling and sensations of a “lump in the throat”. Such symptoms should always be a reason to consult a doctor.
  11. Disorders of the heart and blood vessels. Thyroid hormones have a pronounced effect on work. With hypothyroidism, the patient experiences a slowing of the heartbeat, with the most minimal loads and, and with hyperfunction of the gland - an increase in heart rate (more than 80 beats per minute), pain in the chest, a feeling of compression of the heart, a noticeable pulsation of the vessels of the neck and a pronounced sensation of palpitations (person " hears the heart beating). Over time, hyperthyroidism can lead to the development of severe symptoms.
  12. Swelling of the eyelids, puffiness and puffiness of the face. Disturbances in the functioning of the heart caused by hypothyroidism lead to insufficient blood flow and the appearance of edema. As a rule, swelling appears at night and disappears on its own after waking up.
  13. Muscle pain, numbness or tingling in the limbs. The appearance of these complaints is associated with disturbances in protein metabolism and a decrease in muscle volume due to hyperfunction of the gland. Also hormonal imbalance causes changes in the conduction of nerve impulses, which cause sensations of numbness and tingling.
  14. Bone changes, osteoporosis. Disturbances in the synthesis of calcitonin and in calcium-phosphorus metabolism lead to a decrease in calcium levels and a deterioration in its absorption. As a result, the bones do not receive enough of this “building” material and. Bone changes can cause the appearance, deformation and gradual destruction.
  15. Dizziness and frequent headaches. provoked by fluctuations blood pressure and vegetative-vascular disorders that often accompany a state of thyroid hormone imbalance.

To identify the causes of the above symptoms and make an accurate diagnosis, you must consult an endocrinologist. Based on the data obtained during the examination and interview of the patient, the specialist will be able to draw up a productive plan for further examination. After analyzing all the research results, the doctor will prescribe measures to treat the identified thyroid disease. For this purpose, the patient may be recommended therapeutic or surgical techniques, allowing to correct the functioning of this organ.

Do not put off a visit to an endocrinologist “until later” when you identify the first signs of thyroid disease. Remember that any pathology of this organ is better treated with initial stages. Be healthy!

Most people, after sleeping through a morning run or falling asleep while watching their favorite TV series, say they are simply tired. But if they wanted to know the real reason With their fatigue chaining them to their bed, they should talk to someone who has thyroid disease.

No more strength!

Feelings of fatigue and exhaustion were absolutely not typical for me. I have always been a very energetic person. Six hours of sleep at night was enough for me.

But since last fall, I have become a different person, whom I myself did not like very much. I struggled to get up in the morning to take the kids to school and then go back to bed, often falling asleep before 10 or even 11, while suffering acutely from the consciousness of my guilt.

But just at that moment my younger sister discovered a thyroid problem, and her doctor said there might be a family history of the disease.

And when I read the list possible symptoms with thyroid disease: depression, constipation, hair loss, weight gain and others - everything fell into place. I have hypothyroidism. I am one of millions of people suffering from this disease.

On the brakes!

The thyroid gland is a tiny, butterfly-shaped gland at the base of the neck that controls the flow of energy in the body. Hypothyroidism, also called an underactive thyroid, means that the gland does not produce enough hormones to do its job. The most common cause is Hashimoto's thyroiditis, a condition that causes the body to produce antibodies that attack its own thyroid gland. Lack of thyroid hormones makes a person sluggish. Slow digestion causes constipation, decreased metabolism leads to weight gain and high cholesterol, hair and skin, lacking many nutrients, become dry and rough (and the hair may also fall out).

The brain also needs thyroid hormones to use oxygen and stimulate the production of serotonin and dopamine, which regulate emotions. This is why hypothyroidism can lead to depression and moodiness, not to mention the blurred thinking that almost every patient with this disease complains about. Other signs, such as weight gain, cramps and stomach discomfort, aren't specific enough to alert doctors to a thyroid problem, but they're no less troublesome.

Some experts estimate that women over 35 today have a 35% risk of developing thyroid disease. But many experts think that these numbers are even higher because a significant proportion of patients are not aware of their diagnosis.

Here are the reasons for the unprecedented rise in popularity of the disease:

Stress

It is ubiquitous these days. Many hypothyroidism specialists recommend that patients try yoga, meditation, and other stress-relieving techniques, which could help prevent immune system problems such as Hashimoto's thyroiditis, the most common reason hypothyroidism.

Environmental intoxication

Some toxins destroy the human endocrine system, disrupting the synthesis of hormones. Currently, the American Thyroid Association has taken up the topic of environmental influences on the function of this organ.

Nutritional deficiencies

Too much or too little iodine, deficiency of selenium in the soil, fluoride in water and too much a large number of Soy in today's food may also be responsible for the prevalence of hypothyroidism.

Action plan

If you suspect you have hypothyroidism, check for the symptoms listed below:

  • increased fatigue or complete absence strength
  • severe drowsiness
  • decreased tone
  • unfounded concern
  • irritability
  • indifference to sex
  • constipation
  • forgetfulness
  • increased chilliness
  • frequent seizures
  • nausea
  • unexplained weight gain despite dieting
  • thinning or loss of hair
  • dry skin and hair
  • high cholesterol
  • high blood pressure
  • painful or longer than normal periods
  • low hoarse voice

If you find something from this list in yourself, we recommend the following course of action.

List your symptoms. Write them down. For example, you can't go through the day without taking a nap, or you've gained 10 kg despite walking 5 times a week and following a diet.

Ask relatives, including siblings, parents, siblings, cousins, and grandparents, if they have a history of thyroid problems or if they have ever received supplemental thyroid hormones.

Tell your doctor all this and ask him to order a TSH test for you. This is a blood test that checks your thyroid hormone levels. Find out your exact score, not just whether it's in the "normal" range. Some endocrinology experts now say the normal range is between 0.3 and 3.0. This means that a TSH above 3 would indicate hypothyroidism. But many laboratories have not adopted the new criteria for assessing this indicator and still do not consider a result of 4 or even 5 as high.

Check again in 3 months. If you have been prescribed treatment, you will be able to understand whether it is helping.

Ask for a thyroid antibody test - Anti-TPO. If your TSH test is normal but you are not feeling well, this test may help determine if you have hypothyroidism.

Perform additional hormonal tests. Doctors should check your T3 and T4 hormone levels, which can give a more accurate picture of how your thyroid is functioning.

Everything is individual

The “One size” approach is impossible here - one size for everyone. You may have to make several visits to doctors to get the correct prescriptions, and subsequent treatment may also change. The point of treatment is replacement therapy synthetic analogs of thyroid hormones.

The doctor selects the dose individually, depending on the depth of hypothyroidism, the patient’s age, and his condition. of cardio-vascular system, the presence of other pathology. With the correct dose of the drug, the level of thyroid-stimulating hormone is within normal values. Control is carried out once every 6-12 months.

Structure, functions and significance of the thyroid gland

Thyroid (glandula thyroidea) - endocrine gland, part of the endocrine system, synthesizes a number of hormones necessary to maintain homeostasis in the body.

Thyroid gland (colloquially "thyroid gland")- a symmetrical organ, consists of two lobes and an isthmus. Right and left lobe adjacent directly to the trachea, the isthmus is located on the anterior surface of the trachea. Some authors separately highlight thyroid gland pyramidal lobe. In a normal (euthyroid) state, the mass thyroid gland ranges from 20 to 65 g, and the size of the lobes depends on gender and age characteristics and can vary within fairly wide limits. During puberty, there is an increase in size and thyroid mass, and in old age, accordingly - its decrease. During pregnancy, women also experience a temporary increase in the size of the thyroid gland, which goes away on its own, without treatment, within 6-12 months after birth.

Occurs in the thyroid gland synthesis of two iodine-containing hormones - thyroxine (T 4) and triiodothyronine (T 3), and one peptide hormone- calcitonin. In the tissue of the thyroid gland, the amino acid tyrosine accumulates, which is deposited and stored in the form of a protein - thyroglobulin ( building material for the synthesis of thyroid hormones). In the presence of molecular iodine and the activation of the enzyme thyroid peroxidase (TPO), the hormones T3 and T4 are synthesized. Thyroxine (T4) and triiodothyronine (T3) are synthesized in the apical part of the thyroid epithelium. Calcitonin (thyrocalcitonin) is produced by the parathyroid glands, as well as the C-cells of the thyroid gland.

Thyroid hormones are the main regulators of homeostasis human body. With their direct participation, the main metabolic processes occur in tissues and organs; formation of new cells and their structural differentiation takes place, as well as genetically programmed death of old cells (apoptosis). Other no less important function thyroid hormones in the body is to maintain constant temperature body and energy production (the so-called calorigenic effect). Thyroid hormones regulate the body's oxygen consumption by tissues, the processes of oxidation and energy production, and also control the formation and neutralization of free radicals. Throughout life, thyroid-stimulating hormones influence mental, psychological and physical development body. Hormone deficiency in early age leads to growth retardation and can cause diseases bone tissue, and their deficiency during pregnancy significantly increases the risk of cretinism in the unborn child due to underdevelopment of the brain during the prenatal period. Thyroid hormones are also responsible for normal functioning immunity - they stimulate cells immune system, so-called T cells, which the body uses to fight infection.

Prevalence of thyroid diseases

According to the World Health Organization (WHO), among endocrine disorders Thyroid diseases rank second after diabetes mellitus. More than 665 million people in the world have endemic goiter or suffer from other thyroid pathologies; 1.5 billion people are at risk of developing iodine deficiency diseases. Moreover, according to statistics, the increase in the number of thyroid diseases in the world is 5% per year.

According to various sources, from 15 to 40% of the Russian population suffer from thyroid pathologies, while in some regions the percentage of patients in need of thyroid treatment approaches 95%. Statistics show that every second person living in Moscow and the Moscow region has a dysfunction or structure of the thyroid gland.

Among possible reasons The development of thyroid pathologies can primarily be attributed to poor environmental conditions, lack of iodine and other nutrients in the diet, as well as increasingly common genetic disorders.

Diagnosis of thyroid diseases

To select the correct treatment, diagnosing patients with thyroid diseases should include physical, instrumental and laboratory methods for assessing its morphological structure and functional activity. For example, by palpation (tactile palpation with fingers) of the thyroid gland, you can determine its size, the consistency of the thyroid tissue and the presence or absence of nodules. By far the most informative laboratory method determining the concentration of thyroid hormones in the blood is linked immunosorbent assay carried out using standard test kits. Besides, functional state of the thyroid gland estimated by the absorption of the isotope 131 I or technetium 99m Tc.

Ultrasound examination (ultrasound) of the thyroid gland.

Modern assessment methods thyroid structures also include ultrasound diagnostics(ultrasound), computed tomography(MRI), thermography and scintigraphy. These methods make it possible to obtain information about the size of the organ and the nature of accumulation of the radiocontrast agent in different parts of the gland. Using a fine needle aspiration biopsy(TNA) involves taking thyroid cells for analysis and then studying them.

It should be noted that with all the variety of methods for laboratory monitoring of the thyroid gland, the most quick methods diagnostics are tests to determine the content of free/bound forms of hormones T 3 and T 4, antibodies to thyroglobulin (AT-TG) and to thyroid peroxidase (AT-TPO), as well as the level of thyroid-stimulating hormone (TSH) in the blood plasma. In addition, sometimes a type of analysis is performed to determine iodine excretion in urine. This study allows us to determine whether there is a connection between thyroid disease and iodine deficiency.

Symptoms of thyroid diseases

There is a large number various diseases thyroid gland. Almost all of them, depending on the characteristics of changes in the functional activity of the thyroid gland, can be divided into three large groups.

  1. Diseases accompanied by increased synthesis and/or secretion of thyroid hormones.
    With these pathologies we are talking about thyrotoxicosis.
  2. Diseases accompanied by a decrease in the synthesis of thyroid hormones (T3, T4) and/or a decrease in their concentration in the blood.
    In such cases we are talking about hypothyroidism.
  3. Diseases of the thyroid gland that occur without changes in functional activity and are characterized only by morphological changes in the structure of the organ (formation goiter, education nodes, hyperplasia etc.).

Hypothyroidism

Hypothyroidism (hypofunction) is a condition characterized by a decrease in the level of thyroid hormones, occurs in 19 out of 1000 women, and in 1 out of 1000 men. Often hypothyroidism is not detected long time, because Symptoms of the disease develop very slowly and patients do not complain about their health status. In addition, the symptoms of hypothyroidism can be nonspecific, and the disease can occur hidden behind the “masks” of a number of other diseases, which in turn leads to erroneous diagnosis and incorrect treatment.

With a chronic lack of thyroid hormones in the human body, all metabolic processes slow down, as a result of which the production of energy and heat decreases. Clinical symptoms of hypothyroidism development are:

  • fatigue;
  • weakness;
  • decreased performance;
  • memory impairment;
  • chilliness;
  • swelling;
  • rapid weight gain;
  • dry skin;
  • dullness and brittleness of hair.

In women, hypothyroidism can cause problems menstrual cycle, be the cause of early menopause. One of common symptoms hypothyroidism is depression, for which patients are referred to a psychologist or psychiatrist.

Thyrotoxicosis

Thyrotoxicosis (hyperfunction) - clinical condition, characterized by a persistent increase in the level of thyroid hormones in the blood, which leads to the acceleration of all metabolic processes in the body. Classic symptoms of tereotoxicosis are:

  • irritability and short temper;
  • weight loss (with increased appetite);
  • rapid heartbeat (sometimes with rhythm disturbance);
  • sleep disturbance;
  • constant sweating;
  • elevated body temperature.

Sometimes, and especially in old age, indicated symptoms do not manifest themselves clearly and patients associate their condition not with any disease, but with natural age-related changes in organism. For example, a feeling of heat, “hot flashes”, which are classic signs thyrotoxicosis, can be regarded by women as manifestations of menopause.

A fairly common symptom in patients with thyroid diseases is goiter (formation of the so-called goiter) - an enlargement of the organ beyond the permissible values ​​(the normal volume of the gland in men is 9-25 ml, in women - 9-18 ml). In the euthyroid state, the thyroid gland slightly enlarges adolescence, also in women during pregnancy and after menopause. Depending on whether the entire organ is enlarged or only a separate part of it is enlarged, it is customary to distinguish between diffuse or nodular goiter, respectively.

Causes of development of thyroid diseases

Undoubtedly, genetic factors play an important role in the occurrence of thyroid diseases, which determine a person’s predisposition to a particular disease. But, in addition, the role of various external stress factors in the development of thyroid pathologies is undeniable:

  • psycho-emotional overload;
  • unbalanced diet and, as a result, a lack of vitamins and/or microelements (including iodine deficiency);
  • unfavorable environmental and radiation conditions;
  • infections;
  • chronic diseases;
  • taking some medicines and etc.

It is these factors that are trigger mechanism occurrence of thyroid diseases.

Simply put, the human body is constantly affected by certain reasons that force its thyroid gland to produce an increased or decreased amount of hormones. This leads to the fact that this organ of the endocrine system “wears out” and “fades away”, and becomes unable to synthesize the optimal amount of hormones T3 and T4 for the body’s needs. Ultimately develop either chronic functional disorders thyroid gland (hypo-, hyperthyroidism), or morphological changes in its structure (formation of goiter, formation of nodules, hyperplasia, etc.).

Existing drugs and methods of treating thyroid diseases

Hormonal disorders of the thyroid gland, manifested as hyper- or hypothyroidism, are usually treated with chemotherapy drugs. In Russia, the standard of treatment is the use of thyroid hormone drugs, including: medications such as triiodothyronine, thyroxine, as well as their combinations and complexes with inorganic iodine (iodothyronine, thyrotom, thyrocomb).

These medications compensate for the deficiency of your own thyroid hormones and are usually used for life. This method of treating the thyroid gland is called hormone replacement therapy (HRT). Its main disadvantage is the suppression of the thyroid gland's synthesis of its own thyroid hormones, as a result of which the patient becomes dependent on hormone replacement therapy and can no longer live without pills. Among other side effects of HRT, it is necessary to note the occurrence of allergic reactions to synthetic hormones, violation heart rate, nervous disorders etc.

Carrying out surgery on the thyroid gland (resection, thyroidectomy).

The second class of drugs widely used to treat thyroid diseases are thyreostatics, that is, drugs that disrupt the process of synthesis, production or release of thyroid hormones into the blood. To this group medicines include thiamazole derivatives (tyrosol, mercazolil), thiouracil derivatives (propicyl), as well as diiodotyrosine. Traditionally, thyreostatics are used to suppress increased output thyroid hormones.

However, it must be taken into account that after such treatment, the thyroid tissue of the thyroid gland atrophies, the functional activity of the organ decreases significantly and after some time the patient is forced to switch to hormone replacement therapy. In addition, this class of drugs has significant side effects: nausea, vomiting, suppression of hematopoietic function, liver dysfunction, allergic reactions etc.

A treatment method such as surgery(resection, thyroidectomy) is most often used for pathological changes structures of the thyroid gland. Mandatory testimony for the operation are malignant neoplasms, as well as difficulty swallowing and breathing.

Besides that surgery is the most stressful treatment for the patient, it has other serious disadvantages. First of all, this is the risk of developing postoperative complications, giving about 10 percent of disability (damage to the vocal nerves, removal of the parathyroid glands), as well as lifelong use of hormones.

Promising treatments for thyroid diseases

In addition to medicinal chemotherapy drugs, there are a number of herbal remedies, mainly in the form of dietary supplements, approved for use and used for complex treatment thyroid diseases. Bioadditives of this group can be classified according to their composition as:

  • only iodine-containing (iodine is present in inorganic or organic form);
  • iodine-containing in combination with plant components;
  • completely herbal preparations.

Often in advertising and in pharmacies customers are offered various shapes biologically active additives containing finely divided parts medicinal plants. This form of processing plant raw materials is ineffective for treatment for a number of reasons. It is reliably known that the content of biologically active substances (BAS) in the extract is 5-10 times higher than in the raw materials from which it is made. Therefore, to achieve a similar therapeutic effect it is necessary to take at least 5-10 times more mass units of raw material (mg, g) than the extract. In addition, unscrupulous manufacturers include crushed parts of plants with obviously no pharmacological effect in the composition of drugs. In phytopharmaceuticals, such a phenomenon as organ-specific accumulation of biologically active substances is well known (for example, in the roots there is a high content active ingredients, in grass their concentration is 0%). This technique manufacturers of dietary supplements is a deliberate deception of uninformed consumers. It should also be noted that taking dietary supplements containing crushed parts of plants is often dangerous for the health of consumers (there is a high microbial contamination of raw materials, dyspeptic symptoms occur when taken - heaviness in the abdomen, bloating, flatulence, nausea, colic, exacerbation of gastrointestinal diseases- constipation, impaired peristalsis, appendicitis), etc. But, perhaps, the main disadvantage of such products is the low bioavailability of biologically active substances of whole plant raw materials and high concentration ballast substances, which sharply reduces pharmacological effect from taking these drugs.

Today, the greatest interest among clinicians, especially endocrinologists and endocrinologists-gynecologists, is the drug ENDONORM ®. Thanks to the content of clinically proven medicinal plant extracts, this drug has high therapeutic effectiveness in the treatment of thyroid diseases such as hypo- and hyperthyroidism, autoimmune thyroiditis, nodular/multinodular goiter, as well as other disorders of the thyroid gland.

What does a person need to be completely happy? Be healthy both physically and mentally. Physical and mental condition are closely related to each other. And hormonal levels regulate these conditions. Thyroid diseases are common among the population, which is why thyroid health should be given special attention.

General information about the organ

The thyroid gland is a small organ of the endocrine system (about the size of a child's fist) that is located in the front of the neck. Consists of two lobes with connective tissue between them. We can say that this gland is shaped like a butterfly.

The thyroid gland is responsible for the production of hormones containing iodine: thyroxine and triiodothyronine. They regulate metabolism, growth of the human body, the functioning of the cardiovascular system, gastrointestinal tract and reproductive system. The gland also produces a hormone that is responsible for regulating calcium levels in the body - calcitonin.

You should know that the gland itself does not control the amount of hormone production. Regulates the functioning of the thyroid gland thyroid-stimulating hormone, which is secreted by the pituitary gland, is a gland located in the brain.

In organism healthy person Slight fluctuations in hormones are possible. And to understand whether a person is healthy, medical workers The concentration of total and free fractions of T3 (thyroxine) and T4 (triiodothyronine) is examined, along with the concentration of TSH (thyroid-stimulating hormone).

Hormone concentrations in a healthy person:

  • triiodothyronine (T3) total (1.08−3.14 nmol/l);
  • free triiodothyronine (T3) (2.6−5.7 nmol/l);
  • total thyroxine (T4) (55−137 nmol/l);
  • thyroxine (T4) free (9−22 nmol/l);
  • thyroid-stimulating hormone (TSH) (0.4−4.0 mU/l).

If the patient or the attending physician has doubts, then the blood test must be repeated to accurately verify the diagnosis or the absence of pathology.

Thyroid diseases can develop in two directions: decreased endocrine function(hypothyroidism) or increased endocrine function (hyperthyroidism, thyrotoxicosis). Some pathologies arise due to an increase in the level of iodine in the body, which can provoke cretinism or endemic goiter.

First symptoms

The thyroid gland is most often affected in women. Symptoms of the disease and treatment must be monitored by a doctor. To prevent and stop the development of the disease, you need to listen to your body and observe changes in it.

The following signs are distinguished thyroid disease in women:

Thus, when the functioning of the gland is disrupted, signs of other diseases appear, which is fraught with not very good consequences.

Without understanding the cause of the disease, a person can treat something completely different from what is needed, and this will lead to advanced stages of the disease and even greater problems. Therefore, it is necessary to pay attention to all signs of pathology of this organ. If several symptoms appear together, you should urgently consult an endocrinologist.

Causes of the disease

Some diseases arise due to exposure to external factors (radiation, ultraviolet radiation, air and water pollution, etc.) or the appearance of mutations in genes. Mutations can form either spontaneously or under the influence of mutagens. A person cannot always prevent the development of a disease, even by healthy image life. However, you should know what can trigger the appearance of pathology in the thyroid gland.

Causes of thyroid diseases are:

Disruption

According to statistics, every tenth resident is diagnosed with pathological condition thyroid glands According to the World Health Organization, women are most susceptible to the disease, with the risk increasing significantly after age 30.

This disease has several names: Graves' disease, diffuse goiter. This pathology is characterized by excessive production of its own hormones, which leads to poisoning of the body and occurs.

Most often this is a hereditary disease. But there are other factors that can affect the development of Graves' disease: mental trauma, infectious diseases, traumatic brain injuries, nasopharyngeal diseases.

This disease occurs 8 times more often in women than in men. The age at which this pathology occurs is approximately 30 to 60 years. Graves' disease can also occur in adolescents, pregnant women, and women going through menopause.

One of obvious signs diffuse goiter are bulging eyes and goiter. The following manifestations should also be included:

If several symptoms appear, you should consult an endocrinologist. After all, timely initiation of therapy will help protect the body from negative consequences.

Treatment of this disease has three options:

Hashimoto's disease occurs when the immune system is defective, when antibodies begin to mistake organ cells for foreign ones and destroy them. With this disease, hypothyroidism develops. Most often, the disease is chronic and can be transmitted genetically. Research by the Japanese doctor, after whom the disease was named, showed that organ pathologies can develop not only with a lack of iodine in the body, but also with its excess. Thus, the main work of the gland in producing hormones is “turned off”.

Hashimoto's disease is not as noticeable as the previous one; visually its signs are quite difficult to determine. But there are several symptoms that indicate it:

  • fatigue, drowsiness;
  • weight gain;
  • dry and brittle hair;
  • constipation;
  • chills;
  • irregular and painful menstruation.

If there are such deviations in the condition of the thyroid gland, the symptoms of the disease and treatment will also differ from such a pathology as diffuse goiter. Therapy may be as follows:

  • Use of thyroid drugs. These are hormonal drugs that contain thyroxine, triiodothyronine, thyroidine, L-thyroxine.
  • Surgical intervention. They operate on severe enlargement of the gland, when compression of blood vessels and respiratory tract occurs.
  • Use of selenium preparations. These drugs are used as supplements. Studies have shown that they reduce the amount of antibodies that destroy thyroid cells and significantly improve the health of patients.

The nodes can be located both inside the gland and on top of it. Some are just solid, and some are filled with liquid. Most often this benign tumors, but less often with incorrect or untimely treatment they can transform into cancerous tumors.

They occur with iodine deficiency, and therefore the symptoms will be similar to the previous disease: drowsiness, fatigue, weight gain, etc.

Most often, the nodules are not touched, but simply observed. With a strong increase, they already move on to surgical intervention.

Diagnosis of pathology

If you have the described symptoms, you should contact an endocrinologist. He will appoint necessary tests and ultrasound to determine health status. A blood test will show the concentration of hormones, and with the help of an ultrasound it will be possible to examine whether there are significant enlargements or nodules in the thyroid gland.

You can conduct the examination at home yourself.

One of the most known methods- This iodine mesh. You need to draw it on your forearm and after a while (2-3 hours) see if it has disappeared. If iodine is absorbed too quickly, this may indicate that the person has hypothyroidism. If the mesh has clear outlines, then hyperthyroidism is possible.

You can also check for thyroid disease in the eyes. You need to time it and count the number of blinks per minute. The norm is 20−30 times. If blinking is slower, then the eyelid may be freezing, which is a sign of thyrotoxicosis.

If you notice that the hairline is becoming thinner, then you urgently need to contact an endocrinologist.

Another way is to check for goiter. You need to go to the mirror with a glass of water. Take water into your mouth, lift your chin and swallow. If any formation is noticed between the middle part of the throat and the collarbones, then this is a clear reason to consult a doctor.

Prevention measures

The thyroid gland is a gland that controls the functioning of all organs, so you need to know about thyroid diseases, their symptoms in women and treatment. To avoid health problems, Doctors recommend following these rules:

Thus, there are many reasons for the occurrence of thyroid dysfunction. You need to remember the recommendations and undergo regular diagnostics, then the chances of developing thyroid disease will be significantly reduced.

The butterfly-shaped organ located in the front of the neck is called the thyroid gland. It affects almost all metabolic processes in the body and “produces” several important ones - calciotonin, triiodothyronine and thyroxine.

Triiodothyronine and thyroxine are hormones that have a direct effect on the functioning of the digestive and cardiovascular systems, allow you to control mental and mental activity, regulate protein, fat and carbohydrate metabolism. Certain Kind Thyroid cells synthesize the most valuable hormone calciotonin - it controls the level of calcium in the body.

General characteristics of thyroid pathologies

Even with minor disturbances in the functioning of the thyroid gland, a significant deterioration in health is observed - the organ in question is responsible for the functioning of all body systems. Usually, with diseases of the thyroid gland, we are talking about insufficient or, conversely, excessive synthesis of hormones; often such phenomena are accompanied by an enlargement of the organ in question.

In general, the appearance of specific symptoms of thyroid disease will depend on what hormones and in what quantities are produced by the organ in question. Well, only a specialist should make an accurate diagnosis, and he will do this only after conducting a full examination. The following are carried out:

  • ultrasound examination of the thyroid gland;
  • puncture biopsy;
  • scintigraphy.

But a person himself may suspect that he is developing some kind of thyroid disease - there are a number of characteristic symptoms, which doctors categorically do not recommend ignoring.

Of course, ideally, every person should undergo preventive examinations with general and specialized specialists once every 6-12 months. But there are a number of signs that will certainly alert you and force you to visit the clinic for a full examination. These include:

  1. Violation of the psycho-emotional background. It's about about the appearance of irritability, despondency, fatigue without visible reasons. The fact is that it is the level of synthesized thyroid hormones that affects a person’s mood - if it is too low, then they will be clearly noticeable. Bad mood, despondency and depression, but increased level hormones leads to anxiety and irritability.

  1. Weight fluctuations A. In general, rapid weight loss or too rapid weight gain is the most characteristic feature development of thyroid diseases. For example, if a person’s weight progresses, then his weight will steadily increase, but if he does, his weight will rapidly decrease. This condition cannot be stabilized even with strict diets.

  1. Hair loss, changes in the structure of nails and skin. If a person develops, he will definitely complain about skin pigmentation and thickening skin in the area of ​​the feet and legs. And in case of development - brittle nails, dryness and flaking of the skin. Drastic change appearance hair and its loss are a sign of any disease of the thyroid gland, but all of these changes are reversible - as soon as the health and functionality of the organ in question is restored, the condition of the nails, hair and skin will return to its previous level.
  2. Fever or chills. Constantly changing fever and chills are also a sign of thyroid disease. The fact is that if the synthesis of hormones by the organ in question is disrupted, the body’s thermoregulation is also disrupted - if the level of hormones is too high, the patient will complain of constant feeling heat and increased sweating, but when reduced level thyroid hormones - for a feeling of freezing and chills.
  3. Violations in the functioning of organs digestive system . Usually, if there are problems in the functioning of the organ in question, all organs of the gastrointestinal tract suffer, for example, the patient may develop chronic constipation or frequent diarrhea, bile stagnation and insufficient intestinal motility. In addition, diseases of the thyroid gland can provoke the appearance of stones in gallbladder and bile ducts.
  4. Fluctuations in body temperature. If a patient's hypothyroidism progresses, then his body temperature will be slightly reduced and in the normal state this manifestation does not represent anything terrible. But if the background is stable low temperature If an infection occurs in the body, you may miss its first signs, which leads to a more severe course of the infection and the development of complications. With hyperthyroidism, body temperature, on the contrary, is slightly elevated, maximum to subfebrile temperatures.
  5. Menstrual irregularities. This symptom is present both when the level of synthesized hormones is too high and when it is low. As a rule, hypothyroidism leads to scanty and infrequent periods, but hyperthyroidism is characterized by too frequent menstrual bleeding and a shortening of the menstrual cycle. Almost all women diagnosed with thyroid disease suffer from infertility or miscarriage.
  6. Problems in the cardiovascular system. If it progresses, the patient will experience shortness of breath even with small physical activity, slow heartbeat, low blood pressure. With development, on the contrary, the patient will complain of a rapid heartbeat, a regular increase in blood pressure, noticeable pulsation, sensations strong pressure on chest. If hyperthyroidism develops without medical control and no treatment is carried out, this can lead to the development of quite severe and dangerous pathologies heart and blood vessels.
  7. Eye symptoms. This implies the appearance of bulging eyes, photophobia, lacrimation and rare blinking - these symptoms appear with severe hyperfunction of the thyroid gland. Patients complain of decreased visual acuity and a feeling of fullness eyeball. But pain never appears in the eyes - this is a sign of completely different pathologies. If the thyroid disease progresses and no treatment is carried out, the patient develops severe bulging eyes.
  8. Headaches and. When there is an imbalance of the hormones that the thyroid gland synthesizes, fluctuations in blood pressure and vegetative-vascular disorders often occur. It is these factors that provoke frequent and mild dizziness for no apparent reason.
  9. Swelling of the face. With hypothyroidism, a person experiences disturbances in the functioning of the heart, and this, in turn, leads to disturbances metabolic processes and insufficient blood flow - this is the cause of edema. It is noteworthy that specifically in cases of dysfunction of the thyroid gland, swelling of the face appears only at night, and after the patient awakens, they disappear on their own.
  10. Swelling of the neck. If the thyroid gland increases in size, nodes grow on it or progress tumor processes, then the patient’s voice timbre will change, a cough will appear, and problems will arise with swallowing even soft foods and liquids. If, against the background of these symptoms, obvious swelling of the neck appears, then this indicates the development of some pathology of the thyroid gland - you should consult a doctor urgently.
  11. Violation of potency. The thyroid gland synthesizes hormones that regulate and control the functioning of the reproductive system. Therefore, with the progression of any dysfunction of the organ in question, the endocrine system in men and women decreases sexual desire, often develops a stable one.

  1. , increased bone fragility. Periodically appearing pain in the joints and the lack of diagnosis of any disease of the musculoskeletal system should alert a person - most likely, the thyroid gland produces too little calciotonin. It is the violations in calcium metabolism lead to changes in the structure of bone tissue - hence pain in the joints of unknown etiology.
  2. Numbness, tingling and muscle pain. Such health problems arise against the background of hyperfunction of the thyroid gland - protein metabolism is disrupted, which leads to pain in the muscle tissue, and an imbalance of hormones provokes a disruption in the process of nerve impulses - hence numbness and tingling.

It is worth understanding that if at least one of the listed signs of thyroid dysfunction appears, you must immediately seek help. medical care. Modern medicine successfully treats pathologies of the organ of the endocrine system in question, but only if contacting a specialist was timely.